Q96SF2 (TCPQM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative T-complex protein 1 subunit theta-like 2

Gene names

Name:	CCT8L2
Synonyms:	CESK1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the TCP-1 chaperonin family.
Caution	Could be the product of a pseudogene.
Sequence caution	The sequence AAI39843.2 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular protein metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW anion channel activity Traceable author statement Ref.1. Source: ProtInc calcium-activated potassium channel activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	Putative T-complex protein 1 subunit theta-like 2		PRO_0000347339
Natural variations
	Natural variant	320	1	W → R. Ref.1 Ref.2 Ref.4 Ref.5 Corresponds to variant rs2236639 [ dbSNP | Ensembl ].		VAR_046042

Sequences

	Sequence		Length	Mass (Da)
	Q96SF2 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: F7D105C7324D5A30	FASTA	557	59,388
	10 20 30 40 50 60 MDSTVPSALE LPQRLALNPR ESPRSPEEEE PHLLSSLAAV QTLASVIRPC YGPHGRQKFL 70 80 90 100 110 120 VTMKGETVCT GCATAILRAL ELEHPAAWLL REAGQTQAEN SGDGTAFVVL LTEALLEQAE 130 140 150 160 170 180 QLLKAGLPRP QLREAYATAT AEVLATLPSL AIQSLGPLED PSWALHSVMN THTLSPMDHL 190 200 210 220 230 240 TKLVAHACWA IKELDGSFKP ERVGVCALPG GTLEDSCLLP GLAISGKLCG QMATVLSGAR 250 260 270 280 290 300 VALFACPFGP AHPNAPATAR LSSPADLAQF SKGSDQLLEK QVGQLAAAGI NVAVVLGEVD 310 320 330 340 350 360 EETLTLADKY GIVVIQARSW MEIIYLSEVL DTPLLPRLLP PQRPGKCQRV YRQELGDGLA 370 380 390 400 410 420 VVFEWECTGT PALTVVLRGA TTQGLRSAEQ AVYHGIDAYF QLCQDPRLIP GAGATEMALA 430 440 450 460 470 480 KMLSDKGSRL EGPSGPAFLA FAWALKYLPK TLAENAGLAV SDVMAEMSGV HQGGNLLMGV 490 500 510 520 530 540 GTEGIINVAQ EGVWDTLIVK AQGFRAVAEV VLQLVTVDEI VVAKKSPTHQ EIWNPDSKKT 550 KKHPPPVETK KILGLNN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2." Riazi M.A., Brinkman-Mills P., Johnson A., Naylor S.L., Minoshima S., Shimizu N., Baldini A., McDermid H.E. Genomics 62:90-94(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-320.
[2]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-320.
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-320.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-320. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP000365 Genomic DNA. Translation: BAA84680.1. AP003553 Genomic DNA. Translation: BAB43952.1. CR456508 mRNA. Translation: CAG30394.1. AP000547 Genomic DNA. No translation available. CH471193 Genomic DNA. Translation: EAW57714.1. BC033797 mRNA. Translation: AAH33797.1. BC100811 mRNA. Translation: AAI00812.1. BC100812 mRNA. Translation: AAI00813.1. BC100813 mRNA. Translation: AAI00814.1. BC139842 mRNA. Translation: AAI39843.2. Sequence problems.
IPI	IPI00979247.
RefSeq	NP_055221.1. NM_014406.4.
UniGene	Hs.128342.
3D structure databases
ProteinModelPortal	Q96SF2.
SMR	Q96SF2. Positions 27-525.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000353048.
Polymorphism databases
DMDM	74717301.
Proteomic databases
PaxDb	Q96SF2.
PRIDE	Q96SF2.
Protocols and materials databases
DNASU	150160.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359963; ENSP00000353048; ENSG00000198445.
GeneID	150160.
KEGG	hsa:150160.
UCSC	uc002zlp.1. human.
Organism-specific databases
CTD	150160.
GeneCards	GC22M017071.
HGNC	HGNC:15553. CCT8L2.
HPA	HPA039268. HPA041336. HPA045440.
neXtProt	NX_Q96SF2.
PharmGKB	PA162382100.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0459.
HOGENOM	HOG000131368.
HOVERGEN	HBG098338.
InParanoid	Q96SF2.
OMA	QLCQDPR.
OrthoDB	EOG4VX252.
PhylomeDB	Q96SF2.
Gene expression databases
Bgee	Q96SF2.
CleanEx	HS_CCT8L2.
Genevestigator	Q96SF2.
Family and domain databases
InterPro	IPR017998. Chaperone_TCP-1. IPR002423. Cpn60/TCP-1. [Graphical view]
PANTHER	PTHR11353. PTHR11353. 1 hit.
Pfam	PF00118. Cpn60_TCP1. 1 hit. [Graphical view]
PRINTS	PR00304. TCOMPLEXTCP1.
SUPFAM	SSF48592. GroEL-ATPase. 1 hit.
PROSITE	PS00750. TCP1_1. False negative. PS00751. TCP1_2. False negative. PS00995. TCP1_3. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	150160.
NextBio	86350.

Entry information

Entry name

TCPQM_HUMAN

Accession

Primary (citable) accession number: Q96SF2
Secondary accession number(s): A4QPH3, Q9UJS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.