Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

T-complex protein 1 subunit theta-like 2

Gene

CCT8L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.By similarity

Miscellaneous

Presence of two highly similar CCT8L genes (CCT8L1P and CCT8L2) in the genomes of human and chimp and of a single copy in other mammal genomes, including rhesus monkey, suggests that the duplication of this gene occurred in the ape lineage (Hominoidea) after its divergence from the old-world monkeys (Cercopithecidae).1 Publication
Expression of CCT8L2 is confirmed by many ESTs mostly identified from the testis.1 Publication

GO - Molecular functioni

  • anion channel activity Source: ProtInc
  • ATP binding Source: UniProtKB-KW
  • calcium-activated potassium channel activity Source: ProtInc
  • protein binding involved in protein folding Source: GO_Central
  • unfolded protein binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit theta-like 2
Gene namesi
Name:CCT8L2
Synonyms:CESK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000198445.4
HGNCiHGNC:15553 CCT8L2
neXtProtiNX_Q96SF2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198445
PharmGKBiPA162382100

Polymorphism and mutation databases

BioMutaiCCT8L2
DMDMi313104021

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003473391 – 557T-complex protein 1 subunit theta-like 2Add BLAST557

Proteomic databases

PaxDbiQ96SF2
PeptideAtlasiQ96SF2
PRIDEiQ96SF2

PTM databases

PhosphoSitePlusiQ96SF2

Expressioni

Gene expression databases

BgeeiENSG00000198445
CleanExiHS_CCT8L2
GenevisibleiQ96SF2 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ96SF2, 1 interactor
MINTiQ96SF2
STRINGi9606.ENSP00000353048

Structurei

3D structure databases

ProteinModelPortaliQ96SF2
SMRiQ96SF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0362 Eukaryota
ENOG410XPXR LUCA
GeneTreeiENSGT00550000074783
HOGENOMiHOG000131368
HOVERGENiHBG098338
InParanoidiQ96SF2
OMAiQLCQDPR
OrthoDBiEOG091G05LP
PhylomeDBiQ96SF2
TreeFamiTF105699

Family and domain databases

Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR017998 Chaperone_TCP-1
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits

Sequencei

Sequence statusi: Complete.

Q96SF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSTVPSALE LPQRLALNPR ESPRSPEEEE PHLLSSLAAV QTLASVIRPC
60 70 80 90 100
YGPHGRQKFL VTMKGETVCT GCATAILRAL ELEHPAAWLL REAGQTQAEN
110 120 130 140 150
SGDGTAFVVL LTEALLEQAE QLLKAGLPRP QLREAYATAT AEVLATLPSL
160 170 180 190 200
AIQSLGPLED PSWALHSVMN THTLSPMDHL TKLVAHACWA IKELDGSFKP
210 220 230 240 250
ERVGVCALPG GTLEDSCLLP GLAISGKLCG QMATVLSGAR VALFACPFGP
260 270 280 290 300
AHPNAPATAR LSSPADLAQF SKGSDQLLEK QVGQLAAAGI NVAVVLGEVD
310 320 330 340 350
EETLTLADKY GIVVIQARSW MEIIYLSEVL DTPLLPRLLP PQRPGKCQRV
360 370 380 390 400
YRQELGDGLA VVFEWECTGT PALTVVLRGA TTQGLRSAEQ AVYHGIDAYF
410 420 430 440 450
QLCQDPRLIP GAGATEMALA KMLSDKGSRL EGPSGPAFLA FAWALKYLPK
460 470 480 490 500
TLAENAGLAV SDVMAEMSGV HQGGNLLMGV GTEGIINVAQ EGVWDTLIVK
510 520 530 540 550
AQGFRAVAEV VLQLVTVDEI VVAKKSPTHQ EIWNPDSKKT KKHPPPVETK

KILGLNN
Length:557
Mass (Da):59,388
Last modified:November 30, 2010 - v2
Checksum:iF7D105C7324D5A30
GO

Sequence cautioni

The sequence AAI39843 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046042320W → R4 PublicationsCorresponds to variant dbSNP:rs2236639Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000365 Genomic DNA Translation: BAA84680.1
AP003553 Genomic DNA Translation: BAB43952.1
CR456508 mRNA Translation: CAG30394.1
AP000547 Genomic DNA No translation available.
CH471193 Genomic DNA Translation: EAW57714.1
BC033797 mRNA Translation: AAH33797.1
BC100811 mRNA Translation: AAI00812.1
BC100812 mRNA Translation: AAI00813.1
BC100813 mRNA Translation: AAI00814.1
BC139842 mRNA Translation: AAI39843.2 Sequence problems.
CCDSiCCDS13738.1
RefSeqiNP_055221.1, NM_014406.4
UniGeneiHs.128342

Genome annotation databases

EnsembliENST00000359963; ENSP00000353048; ENSG00000198445
GeneIDi150160
KEGGihsa:150160
UCSCiuc002zlp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTCPQM_HUMAN
AccessioniPrimary (citable) accession number: Q96SF2
Secondary accession number(s): A4QPH3, Q9UJS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health