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Q96SF2 (TCPQM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative T-complex protein 1 subunit theta-like 2
Gene names
Name:CCT8L2
Synonyms:CESK1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the TCP-1 chaperonin family.

Caution

Could be the product of a pseudogene.

Sequence caution

The sequence AAI39843.2 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Putative T-complex protein 1 subunit theta-like 2
PRO_0000347339

Natural variations

Natural variant3201W → R. Ref.1 Ref.2 Ref.4 Ref.5
Corresponds to variant rs2236639 [ dbSNP | Ensembl ].
VAR_046042

Sequences

Sequence LengthMass (Da)Tools
Q96SF2 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: F7D105C7324D5A30

FASTA55759,388
        10         20         30         40         50         60 
MDSTVPSALE LPQRLALNPR ESPRSPEEEE PHLLSSLAAV QTLASVIRPC YGPHGRQKFL 

        70         80         90        100        110        120 
VTMKGETVCT GCATAILRAL ELEHPAAWLL REAGQTQAEN SGDGTAFVVL LTEALLEQAE 

       130        140        150        160        170        180 
QLLKAGLPRP QLREAYATAT AEVLATLPSL AIQSLGPLED PSWALHSVMN THTLSPMDHL 

       190        200        210        220        230        240 
TKLVAHACWA IKELDGSFKP ERVGVCALPG GTLEDSCLLP GLAISGKLCG QMATVLSGAR 

       250        260        270        280        290        300 
VALFACPFGP AHPNAPATAR LSSPADLAQF SKGSDQLLEK QVGQLAAAGI NVAVVLGEVD 

       310        320        330        340        350        360 
EETLTLADKY GIVVIQARSW MEIIYLSEVL DTPLLPRLLP PQRPGKCQRV YRQELGDGLA 

       370        380        390        400        410        420 
VVFEWECTGT PALTVVLRGA TTQGLRSAEQ AVYHGIDAYF QLCQDPRLIP GAGATEMALA 

       430        440        450        460        470        480 
KMLSDKGSRL EGPSGPAFLA FAWALKYLPK TLAENAGLAV SDVMAEMSGV HQGGNLLMGV 

       490        500        510        520        530        540 
GTEGIINVAQ EGVWDTLIVK AQGFRAVAEV VLQLVTVDEI VVAKKSPTHQ EIWNPDSKKT 

       550 
KKHPPPVETK KILGLNN 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2."
Riazi M.A., Brinkman-Mills P., Johnson A., Naylor S.L., Minoshima S., Shimizu N., Baldini A., McDermid H.E.
Genomics 62:90-94(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-320.
[2]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-320.
[3]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-320.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-320.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP000365 Genomic DNA. Translation: BAA84680.1.
AP003553 Genomic DNA. Translation: BAB43952.1.
CR456508 mRNA. Translation: CAG30394.1.
AP000547 Genomic DNA. No translation available.
CH471193 Genomic DNA. Translation: EAW57714.1.
BC033797 mRNA. Translation: AAH33797.1.
BC100811 mRNA. Translation: AAI00812.1.
BC100812 mRNA. Translation: AAI00813.1.
BC100813 mRNA. Translation: AAI00814.1.
BC139842 mRNA. Translation: AAI39843.2. Sequence problems.
RefSeqNP_055221.1. NM_014406.4.
UniGeneHs.128342.

3D structure databases

ProteinModelPortalQ96SF2.
SMRQ96SF2. Positions 30-524.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000353048.

Polymorphism databases

DMDM313104021.

Proteomic databases

PaxDbQ96SF2.
PRIDEQ96SF2.

Protocols and materials databases

DNASU150160.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359963; ENSP00000353048; ENSG00000198445.
GeneID150160.
KEGGhsa:150160.
UCSCuc002zlp.1. human.

Organism-specific databases

CTD150160.
GeneCardsGC22M017071.
HGNCHGNC:15553. CCT8L2.
HPAHPA039268.
HPA041336.
HPA045440.
neXtProtNX_Q96SF2.
PharmGKBPA162382100.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0459.
HOGENOMHOG000131368.
HOVERGENHBG098338.
InParanoidQ96SF2.
OMAQLCQDPR.
OrthoDBEOG77Q4WC.
PhylomeDBQ96SF2.
TreeFamTF105699.

Gene expression databases

BgeeQ96SF2.
CleanExHS_CCT8L2.
GenevestigatorQ96SF2.

Family and domain databases

Gene3D1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProIPR012721. Chap_CCT_theta.
IPR017998. Chaperone_TCP-1.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERPTHR11353. PTHR11353. 1 hit.
PTHR11353:SF19. PTHR11353:SF19. 1 hit.
PfamPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSPR00304. TCOMPLEXTCP1.
SUPFAMSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi150160.
NextBio86350.

Entry information

Entry nameTCPQM_HUMAN
AccessionPrimary (citable) accession number: Q96SF2
Secondary accession number(s): A4QPH3, Q9UJS3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM