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Q96SF2

- TCPQM_HUMAN

UniProt

Q96SF2 - TCPQM_HUMAN

Protein

Putative T-complex protein 1 subunit theta-like 2

Gene

CCT8L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.By similarity

    GO - Molecular functioni

    1. anion channel activity Source: ProtInc
    2. ATP binding Source: UniProtKB-KW
    3. calcium-activated potassium channel activity Source: ProtInc

    GO - Biological processi

    1. anion transport Source: GOC
    2. cellular protein metabolic process Source: InterPro
    3. potassium ion transmembrane transport Source: GOC
    4. transport Source: ProtInc

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative T-complex protein 1 subunit theta-like 2
    Gene namesi
    Name:CCT8L2
    Synonyms:CESK1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:15553. CCT8L2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162382100.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Putative T-complex protein 1 subunit theta-like 2PRO_0000347339Add
    BLAST

    Proteomic databases

    PaxDbiQ96SF2.
    PRIDEiQ96SF2.

    Expressioni

    Gene expression databases

    BgeeiQ96SF2.
    CleanExiHS_CCT8L2.
    GenevestigatoriQ96SF2.

    Organism-specific databases

    HPAiHPA039268.
    HPA041336.
    HPA045440.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000353048.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96SF2.
    SMRiQ96SF2. Positions 30-524.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TCP-1 chaperonin family.Curated

    Phylogenomic databases

    eggNOGiCOG0459.
    HOGENOMiHOG000131368.
    HOVERGENiHBG098338.
    InParanoidiQ96SF2.
    OMAiQLCQDPR.
    OrthoDBiEOG77Q4WC.
    PhylomeDBiQ96SF2.
    TreeFamiTF105699.

    Family and domain databases

    Gene3Di1.10.560.10. 2 hits.
    3.30.260.10. 2 hits.
    3.50.7.10. 1 hit.
    InterProiIPR017998. Chaperone_TCP-1.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    IPR027410. TCP-1-like_intermed.
    [Graphical view]
    PANTHERiPTHR11353. PTHR11353. 1 hit.
    PfamiPF00118. Cpn60_TCP1. 1 hit.
    [Graphical view]
    PRINTSiPR00304. TCOMPLEXTCP1.
    SUPFAMiSSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96SF2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSTVPSALE LPQRLALNPR ESPRSPEEEE PHLLSSLAAV QTLASVIRPC    50
    YGPHGRQKFL VTMKGETVCT GCATAILRAL ELEHPAAWLL REAGQTQAEN 100
    SGDGTAFVVL LTEALLEQAE QLLKAGLPRP QLREAYATAT AEVLATLPSL 150
    AIQSLGPLED PSWALHSVMN THTLSPMDHL TKLVAHACWA IKELDGSFKP 200
    ERVGVCALPG GTLEDSCLLP GLAISGKLCG QMATVLSGAR VALFACPFGP 250
    AHPNAPATAR LSSPADLAQF SKGSDQLLEK QVGQLAAAGI NVAVVLGEVD 300
    EETLTLADKY GIVVIQARSW MEIIYLSEVL DTPLLPRLLP PQRPGKCQRV 350
    YRQELGDGLA VVFEWECTGT PALTVVLRGA TTQGLRSAEQ AVYHGIDAYF 400
    QLCQDPRLIP GAGATEMALA KMLSDKGSRL EGPSGPAFLA FAWALKYLPK 450
    TLAENAGLAV SDVMAEMSGV HQGGNLLMGV GTEGIINVAQ EGVWDTLIVK 500
    AQGFRAVAEV VLQLVTVDEI VVAKKSPTHQ EIWNPDSKKT KKHPPPVETK 550
    KILGLNN 557
    Length:557
    Mass (Da):59,388
    Last modified:November 30, 2010 - v2
    Checksum:iF7D105C7324D5A30
    GO

    Sequence cautioni

    The sequence AAI39843.2 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti320 – 3201W → R.4 Publications
    Corresponds to variant rs2236639 [ dbSNP | Ensembl ].
    VAR_046042

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000365 Genomic DNA. Translation: BAA84680.1.
    AP003553 Genomic DNA. Translation: BAB43952.1.
    CR456508 mRNA. Translation: CAG30394.1.
    AP000547 Genomic DNA. No translation available.
    CH471193 Genomic DNA. Translation: EAW57714.1.
    BC033797 mRNA. Translation: AAH33797.1.
    BC100811 mRNA. Translation: AAI00812.1.
    BC100812 mRNA. Translation: AAI00813.1.
    BC100813 mRNA. Translation: AAI00814.1.
    BC139842 mRNA. Translation: AAI39843.2. Sequence problems.
    CCDSiCCDS13738.1.
    RefSeqiNP_055221.1. NM_014406.4.
    UniGeneiHs.128342.

    Genome annotation databases

    EnsembliENST00000359963; ENSP00000353048; ENSG00000198445.
    GeneIDi150160.
    KEGGihsa:150160.
    UCSCiuc002zlp.1. human.

    Polymorphism databases

    DMDMi313104021.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000365 Genomic DNA. Translation: BAA84680.1 .
    AP003553 Genomic DNA. Translation: BAB43952.1 .
    CR456508 mRNA. Translation: CAG30394.1 .
    AP000547 Genomic DNA. No translation available.
    CH471193 Genomic DNA. Translation: EAW57714.1 .
    BC033797 mRNA. Translation: AAH33797.1 .
    BC100811 mRNA. Translation: AAI00812.1 .
    BC100812 mRNA. Translation: AAI00813.1 .
    BC100813 mRNA. Translation: AAI00814.1 .
    BC139842 mRNA. Translation: AAI39843.2 . Sequence problems.
    CCDSi CCDS13738.1.
    RefSeqi NP_055221.1. NM_014406.4.
    UniGenei Hs.128342.

    3D structure databases

    ProteinModelPortali Q96SF2.
    SMRi Q96SF2. Positions 30-524.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000353048.

    Polymorphism databases

    DMDMi 313104021.

    Proteomic databases

    PaxDbi Q96SF2.
    PRIDEi Q96SF2.

    Protocols and materials databases

    DNASUi 150160.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359963 ; ENSP00000353048 ; ENSG00000198445 .
    GeneIDi 150160.
    KEGGi hsa:150160.
    UCSCi uc002zlp.1. human.

    Organism-specific databases

    CTDi 150160.
    GeneCardsi GC22M017071.
    HGNCi HGNC:15553. CCT8L2.
    HPAi HPA039268.
    HPA041336.
    HPA045440.
    neXtProti NX_Q96SF2.
    PharmGKBi PA162382100.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0459.
    HOGENOMi HOG000131368.
    HOVERGENi HBG098338.
    InParanoidi Q96SF2.
    OMAi QLCQDPR.
    OrthoDBi EOG77Q4WC.
    PhylomeDBi Q96SF2.
    TreeFami TF105699.

    Miscellaneous databases

    GenomeRNAii 150160.
    NextBioi 86350.

    Gene expression databases

    Bgeei Q96SF2.
    CleanExi HS_CCT8L2.
    Genevestigatori Q96SF2.

    Family and domain databases

    Gene3Di 1.10.560.10. 2 hits.
    3.30.260.10. 2 hits.
    3.50.7.10. 1 hit.
    InterProi IPR017998. Chaperone_TCP-1.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    IPR027410. TCP-1-like_intermed.
    [Graphical view ]
    PANTHERi PTHR11353. PTHR11353. 1 hit.
    Pfami PF00118. Cpn60_TCP1. 1 hit.
    [Graphical view ]
    PRINTSi PR00304. TCOMPLEXTCP1.
    SUPFAMi SSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2."
      Riazi M.A., Brinkman-Mills P., Johnson A., Naylor S.L., Minoshima S., Shimizu N., Baldini A., McDermid H.E.
      Genomics 62:90-94(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-320.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-320.
    3. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-320.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-320.
      Tissue: Brain.

    Entry informationi

    Entry nameiTCPQM_HUMAN
    AccessioniPrimary (citable) accession number: Q96SF2
    Secondary accession number(s): A4QPH3, Q9UJS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3