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Q96SF2

- TCPQM_HUMAN

UniProt

Q96SF2 - TCPQM_HUMAN

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Protein

Putative T-complex protein 1 subunit theta-like 2

Gene

CCT8L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini

Functioni

Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.By similarity

GO - Molecular functioni

  1. anion channel activity Source: ProtInc
  2. ATP binding Source: UniProtKB-KW
  3. calcium-activated potassium channel activity Source: ProtInc

GO - Biological processi

  1. anion transport Source: GOC
  2. cellular protein metabolic process Source: InterPro
  3. potassium ion transmembrane transport Source: GOC
  4. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative T-complex protein 1 subunit theta-like 2
Gene namesi
Name:CCT8L2
Synonyms:CESK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:15553. CCT8L2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382100.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Putative T-complex protein 1 subunit theta-like 2PRO_0000347339Add
BLAST

Proteomic databases

PaxDbiQ96SF2.
PRIDEiQ96SF2.

Expressioni

Gene expression databases

BgeeiQ96SF2.
CleanExiHS_CCT8L2.
GenevestigatoriQ96SF2.

Organism-specific databases

HPAiHPA039268.
HPA041336.
HPA045440.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353048.

Structurei

3D structure databases

ProteinModelPortaliQ96SF2.
SMRiQ96SF2. Positions 30-524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiCOG0459.
GeneTreeiENSGT00550000074783.
HOGENOMiHOG000131368.
HOVERGENiHBG098338.
InParanoidiQ96SF2.
OMAiQLCQDPR.
OrthoDBiEOG77Q4WC.
PhylomeDBiQ96SF2.
TreeFamiTF105699.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96SF2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSTVPSALE LPQRLALNPR ESPRSPEEEE PHLLSSLAAV QTLASVIRPC
60 70 80 90 100
YGPHGRQKFL VTMKGETVCT GCATAILRAL ELEHPAAWLL REAGQTQAEN
110 120 130 140 150
SGDGTAFVVL LTEALLEQAE QLLKAGLPRP QLREAYATAT AEVLATLPSL
160 170 180 190 200
AIQSLGPLED PSWALHSVMN THTLSPMDHL TKLVAHACWA IKELDGSFKP
210 220 230 240 250
ERVGVCALPG GTLEDSCLLP GLAISGKLCG QMATVLSGAR VALFACPFGP
260 270 280 290 300
AHPNAPATAR LSSPADLAQF SKGSDQLLEK QVGQLAAAGI NVAVVLGEVD
310 320 330 340 350
EETLTLADKY GIVVIQARSW MEIIYLSEVL DTPLLPRLLP PQRPGKCQRV
360 370 380 390 400
YRQELGDGLA VVFEWECTGT PALTVVLRGA TTQGLRSAEQ AVYHGIDAYF
410 420 430 440 450
QLCQDPRLIP GAGATEMALA KMLSDKGSRL EGPSGPAFLA FAWALKYLPK
460 470 480 490 500
TLAENAGLAV SDVMAEMSGV HQGGNLLMGV GTEGIINVAQ EGVWDTLIVK
510 520 530 540 550
AQGFRAVAEV VLQLVTVDEI VVAKKSPTHQ EIWNPDSKKT KKHPPPVETK

KILGLNN
Length:557
Mass (Da):59,388
Last modified:November 30, 2010 - v2
Checksum:iF7D105C7324D5A30
GO

Sequence cautioni

The sequence AAI39843.2 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti320 – 3201W → R.4 Publications
Corresponds to variant rs2236639 [ dbSNP | Ensembl ].
VAR_046042

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000365 Genomic DNA. Translation: BAA84680.1.
AP003553 Genomic DNA. Translation: BAB43952.1.
CR456508 mRNA. Translation: CAG30394.1.
AP000547 Genomic DNA. No translation available.
CH471193 Genomic DNA. Translation: EAW57714.1.
BC033797 mRNA. Translation: AAH33797.1.
BC100811 mRNA. Translation: AAI00812.1.
BC100812 mRNA. Translation: AAI00813.1.
BC100813 mRNA. Translation: AAI00814.1.
BC139842 mRNA. Translation: AAI39843.2. Sequence problems.
CCDSiCCDS13738.1.
RefSeqiNP_055221.1. NM_014406.4.
UniGeneiHs.128342.

Genome annotation databases

EnsembliENST00000359963; ENSP00000353048; ENSG00000198445.
GeneIDi150160.
KEGGihsa:150160.
UCSCiuc002zlp.1. human.

Polymorphism databases

DMDMi313104021.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000365 Genomic DNA. Translation: BAA84680.1 .
AP003553 Genomic DNA. Translation: BAB43952.1 .
CR456508 mRNA. Translation: CAG30394.1 .
AP000547 Genomic DNA. No translation available.
CH471193 Genomic DNA. Translation: EAW57714.1 .
BC033797 mRNA. Translation: AAH33797.1 .
BC100811 mRNA. Translation: AAI00812.1 .
BC100812 mRNA. Translation: AAI00813.1 .
BC100813 mRNA. Translation: AAI00814.1 .
BC139842 mRNA. Translation: AAI39843.2 . Sequence problems.
CCDSi CCDS13738.1.
RefSeqi NP_055221.1. NM_014406.4.
UniGenei Hs.128342.

3D structure databases

ProteinModelPortali Q96SF2.
SMRi Q96SF2. Positions 30-524.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000353048.

Polymorphism databases

DMDMi 313104021.

Proteomic databases

PaxDbi Q96SF2.
PRIDEi Q96SF2.

Protocols and materials databases

DNASUi 150160.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359963 ; ENSP00000353048 ; ENSG00000198445 .
GeneIDi 150160.
KEGGi hsa:150160.
UCSCi uc002zlp.1. human.

Organism-specific databases

CTDi 150160.
GeneCardsi GC22M017071.
HGNCi HGNC:15553. CCT8L2.
HPAi HPA039268.
HPA041336.
HPA045440.
neXtProti NX_Q96SF2.
PharmGKBi PA162382100.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0459.
GeneTreei ENSGT00550000074783.
HOGENOMi HOG000131368.
HOVERGENi HBG098338.
InParanoidi Q96SF2.
OMAi QLCQDPR.
OrthoDBi EOG77Q4WC.
PhylomeDBi Q96SF2.
TreeFami TF105699.

Miscellaneous databases

GenomeRNAii 150160.
NextBioi 86350.

Gene expression databases

Bgeei Q96SF2.
CleanExi HS_CCT8L2.
Genevestigatori Q96SF2.

Family and domain databases

Gene3Di 1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProi IPR017998. Chaperone_TCP-1.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view ]
PANTHERi PTHR11353. PTHR11353. 1 hit.
Pfami PF00118. Cpn60_TCP1. 1 hit.
[Graphical view ]
PRINTSi PR00304. TCOMPLEXTCP1.
SUPFAMi SSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2."
    Riazi M.A., Brinkman-Mills P., Johnson A., Naylor S.L., Minoshima S., Shimizu N., Baldini A., McDermid H.E.
    Genomics 62:90-94(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-320.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-320.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-320.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-320.
    Tissue: Brain.

Entry informationi

Entry nameiTCPQM_HUMAN
AccessioniPrimary (citable) accession number: Q96SF2
Secondary accession number(s): A4QPH3, Q9UJS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3