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Protein

T-complex protein 1 subunit theta-like 2

Gene

CCT8L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.By similarity

GO - Molecular functioni

  • anion channel activity Source: ProtInc
  • ATP binding Source: UniProtKB-KW
  • calcium-activated potassium channel activity Source: ProtInc

GO - Biological processi

  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33823-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit theta-like 2
Gene namesi
Name:CCT8L2
Synonyms:CESK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:15553. CCT8L2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198445.
PharmGKBiPA162382100.

Polymorphism and mutation databases

BioMutaiCCT8L2.
DMDMi313104021.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003473391 – 557T-complex protein 1 subunit theta-like 2Add BLAST557

Proteomic databases

PaxDbiQ96SF2.
PeptideAtlasiQ96SF2.
PRIDEiQ96SF2.

PTM databases

PhosphoSitePlusiQ96SF2.

Expressioni

Gene expression databases

BgeeiENSG00000198445.
CleanExiHS_CCT8L2.
GenevisibleiQ96SF2. HS.

Organism-specific databases

HPAiHPA039268.
HPA041336.
HPA045440.

Interactioni

Protein-protein interaction databases

IntActiQ96SF2. 1 interactor.
STRINGi9606.ENSP00000353048.

Structurei

3D structure databases

ProteinModelPortaliQ96SF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0362. Eukaryota.
ENOG410XPXR. LUCA.
GeneTreeiENSGT00550000074783.
HOGENOMiHOG000131368.
HOVERGENiHBG098338.
InParanoidiQ96SF2.
OMAiQLCQDPR.
OrthoDBiEOG091G05LP.
PhylomeDBiQ96SF2.
TreeFamiTF105699.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96SF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSTVPSALE LPQRLALNPR ESPRSPEEEE PHLLSSLAAV QTLASVIRPC
60 70 80 90 100
YGPHGRQKFL VTMKGETVCT GCATAILRAL ELEHPAAWLL REAGQTQAEN
110 120 130 140 150
SGDGTAFVVL LTEALLEQAE QLLKAGLPRP QLREAYATAT AEVLATLPSL
160 170 180 190 200
AIQSLGPLED PSWALHSVMN THTLSPMDHL TKLVAHACWA IKELDGSFKP
210 220 230 240 250
ERVGVCALPG GTLEDSCLLP GLAISGKLCG QMATVLSGAR VALFACPFGP
260 270 280 290 300
AHPNAPATAR LSSPADLAQF SKGSDQLLEK QVGQLAAAGI NVAVVLGEVD
310 320 330 340 350
EETLTLADKY GIVVIQARSW MEIIYLSEVL DTPLLPRLLP PQRPGKCQRV
360 370 380 390 400
YRQELGDGLA VVFEWECTGT PALTVVLRGA TTQGLRSAEQ AVYHGIDAYF
410 420 430 440 450
QLCQDPRLIP GAGATEMALA KMLSDKGSRL EGPSGPAFLA FAWALKYLPK
460 470 480 490 500
TLAENAGLAV SDVMAEMSGV HQGGNLLMGV GTEGIINVAQ EGVWDTLIVK
510 520 530 540 550
AQGFRAVAEV VLQLVTVDEI VVAKKSPTHQ EIWNPDSKKT KKHPPPVETK

KILGLNN
Length:557
Mass (Da):59,388
Last modified:November 30, 2010 - v2
Checksum:iF7D105C7324D5A30
GO

Sequence cautioni

The sequence AAI39843 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046042320W → R.4 PublicationsCorresponds to variant rs2236639dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000365 Genomic DNA. Translation: BAA84680.1.
AP003553 Genomic DNA. Translation: BAB43952.1.
CR456508 mRNA. Translation: CAG30394.1.
AP000547 Genomic DNA. No translation available.
CH471193 Genomic DNA. Translation: EAW57714.1.
BC033797 mRNA. Translation: AAH33797.1.
BC100811 mRNA. Translation: AAI00812.1.
BC100812 mRNA. Translation: AAI00813.1.
BC100813 mRNA. Translation: AAI00814.1.
BC139842 mRNA. Translation: AAI39843.2. Sequence problems.
CCDSiCCDS13738.1.
RefSeqiNP_055221.1. NM_014406.4.
UniGeneiHs.128342.

Genome annotation databases

EnsembliENST00000359963; ENSP00000353048; ENSG00000198445.
GeneIDi150160.
KEGGihsa:150160.
UCSCiuc002zlp.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000365 Genomic DNA. Translation: BAA84680.1.
AP003553 Genomic DNA. Translation: BAB43952.1.
CR456508 mRNA. Translation: CAG30394.1.
AP000547 Genomic DNA. No translation available.
CH471193 Genomic DNA. Translation: EAW57714.1.
BC033797 mRNA. Translation: AAH33797.1.
BC100811 mRNA. Translation: AAI00812.1.
BC100812 mRNA. Translation: AAI00813.1.
BC100813 mRNA. Translation: AAI00814.1.
BC139842 mRNA. Translation: AAI39843.2. Sequence problems.
CCDSiCCDS13738.1.
RefSeqiNP_055221.1. NM_014406.4.
UniGeneiHs.128342.

3D structure databases

ProteinModelPortaliQ96SF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96SF2. 1 interactor.
STRINGi9606.ENSP00000353048.

PTM databases

PhosphoSitePlusiQ96SF2.

Polymorphism and mutation databases

BioMutaiCCT8L2.
DMDMi313104021.

Proteomic databases

PaxDbiQ96SF2.
PeptideAtlasiQ96SF2.
PRIDEiQ96SF2.

Protocols and materials databases

DNASUi150160.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359963; ENSP00000353048; ENSG00000198445.
GeneIDi150160.
KEGGihsa:150160.
UCSCiuc002zlp.2. human.

Organism-specific databases

CTDi150160.
GeneCardsiCCT8L2.
HGNCiHGNC:15553. CCT8L2.
HPAiHPA039268.
HPA041336.
HPA045440.
neXtProtiNX_Q96SF2.
OpenTargetsiENSG00000198445.
PharmGKBiPA162382100.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0362. Eukaryota.
ENOG410XPXR. LUCA.
GeneTreeiENSGT00550000074783.
HOGENOMiHOG000131368.
HOVERGENiHBG098338.
InParanoidiQ96SF2.
OMAiQLCQDPR.
OrthoDBiEOG091G05LP.
PhylomeDBiQ96SF2.
TreeFamiTF105699.

Enzyme and pathway databases

BioCyciZFISH:G66-33823-MONOMER.

Miscellaneous databases

GenomeRNAii150160.
PROiQ96SF2.

Gene expression databases

BgeeiENSG00000198445.
CleanExiHS_CCT8L2.
GenevisibleiQ96SF2. HS.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTCPQM_HUMAN
AccessioniPrimary (citable) accession number: Q96SF2
Secondary accession number(s): A4QPH3, Q9UJS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Presence of two highly similar CCT8L genes (CCT8L1P and CCT8L2) in the genomes of human and chimp and of a single copy in other mammal genomes, including rhesus monkey, suggests that the duplication of this gene occurred in the ape lineage (Hominoidea) after its divergence from the old-world monkeys (Cercopithecidae).1 Publication
Expression of CCT8L2 is confirmed by many ESTs mostly identified from the testis.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.