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Protein

Zinc finger protein 347

Gene

ZNF347

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri569 – 591C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri597 – 619C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri625 – 647C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri653 – 675C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri681 – 703C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri709 – 731C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri737 – 759C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri765 – 787C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170949-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 347
Alternative name(s):
Zinc finger protein 1111
Gene namesi
Name:ZNF347
Synonyms:ZNF1111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16447. ZNF347.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197937.
PharmGKBiPA38143.

Polymorphism and mutation databases

BioMutaiZNF347.
DMDMi296453051.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475451 – 839Zinc finger protein 347Add BLAST839

Proteomic databases

EPDiQ96SE7.
MaxQBiQ96SE7.
PaxDbiQ96SE7.
PeptideAtlasiQ96SE7.
PRIDEiQ96SE7.

PTM databases

iPTMnetiQ96SE7.
PhosphoSitePlusiQ96SE7.

Expressioni

Gene expression databases

BgeeiENSG00000197937.
CleanExiHS_ZNF347.
ExpressionAtlasiQ96SE7. baseline and differential.
GenevisibleiQ96SE7. HS.

Organism-specific databases

HPAiHPA023448.

Interactioni

Protein-protein interaction databases

IntActiQ96SE7. 1 interactor.
STRINGi9606.ENSP00000405218.

Structurei

Secondary structure

1839
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi285 – 287Combined sources3
Turni292 – 294Combined sources3
Beta strandi297 – 301Combined sources5
Helixi302 – 308Combined sources7
Helixi309 – 311Combined sources3
Beta strandi320 – 322Combined sources3
Beta strandi325 – 328Combined sources4
Helixi329 – 336Combined sources8
Helixi338 – 340Combined sources3
Beta strandi348 – 350Combined sources3
Helixi357 – 364Combined sources8
Turni365 – 369Combined sources5
Beta strandi381 – 384Combined sources4
Helixi385 – 395Combined sources11
Beta strandi396 – 398Combined sources3
Beta strandi400 – 402Combined sources3
Beta strandi404 – 406Combined sources3
Beta strandi409 – 412Combined sources4
Helixi413 – 423Combined sources11
Beta strandi424 – 427Combined sources4
Turni460 – 462Combined sources3
Beta strandi465 – 468Combined sources4
Helixi469 – 476Combined sources8
Turni477 – 479Combined sources3
Turni488 – 491Combined sources4
Helixi497 – 504Combined sources8
Turni505 – 507Combined sources3
Beta strandi512 – 514Combined sources3
Turni516 – 518Combined sources3
Helixi525 – 532Combined sources8
Helixi533 – 535Combined sources3
Beta strandi540 – 542Combined sources3
Beta strandi544 – 546Combined sources3
Beta strandi549 – 551Combined sources3
Helixi553 – 564Combined sources12
Beta strandi572 – 574Combined sources3
Helixi581 – 588Combined sources8
Turni589 – 591Combined sources3
Beta strandi594 – 598Combined sources5
Beta strandi600 – 602Combined sources3
Beta strandi605 – 608Combined sources4
Helixi609 – 616Combined sources8
Turni617 – 619Combined sources3
Beta strandi651 – 654Combined sources4
Beta strandi656 – 658Combined sources3
Beta strandi661 – 665Combined sources5
Helixi666 – 671Combined sources6
Beta strandi676 – 678Combined sources3
Beta strandi680 – 682Combined sources3
Helixi693 – 699Combined sources7
Helixi700 – 703Combined sources4
Beta strandi708 – 711Combined sources4
Turni712 – 715Combined sources4
Helixi721 – 728Combined sources8
Turni740 – 742Combined sources3
Helixi749 – 755Combined sources7
Helixi756 – 758Combined sources3
Turni768 – 770Combined sources3
Helixi777 – 784Combined sources8
Turni785 – 789Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EMANMR-A312-344[»]
2EMPNMR-A536-568[»]
2EN4NMR-A284-316[»]
2ENENMR-A592-624[»]
2ENFNMR-A340-372[»]
2EOENMR-A508-540[»]
2EOWNMR-A368-400[»]
2EQ0NMR-A452-484[»]
2EQ1NMR-A480-512[»]
2EQ2NMR-A676-708[»]
2EQ3NMR-A704-736[»]
2YTINMR-A564-596[»]
2YTKNMR-A396-428[»]
2YTNNMR-A732-764[»]
2YTRNMR-A760-792[»]
2YU8NMR-A648-680[»]
ProteinModelPortaliQ96SE7.
SMRiQ96SE7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96SE7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 20 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri569 – 591C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri597 – 619C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri625 – 647C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri653 – 675C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri681 – 703C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri709 – 731C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri737 – 759C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri765 – 787C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96SE7.
KOiK09228.
OMAiKSNGCGM.
PhylomeDBiQ96SE7.
TreeFamiTF341892.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 20 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 13 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 20 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96SE7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALTQGQVTF RDVAIEFSQE EWTCLDPAQR TLYRDVMLEN YRNLASLGIS
60 70 80 90 100
CFDLSIISML EQGKEPFTLE SQVQIAGNPD GWEWIKAVIT ALSSEFVMKD
110 120 130 140 150
LLHKGKSNTG EVFQTVMLER QESQDIEGCS FREVQKNTHG LEYQCRDAEG
160 170 180 190 200
NYKGVLLTQE GNLTHGRDEH DKRDARNKLI KNQLGLSLQS HLPELQLFQY
210 220 230 240 250
EGKIYECNQV EKSFNNNSSV SPPQQMPYNV KTHISKKYLK DFISSLLLTQ
260 270 280 290 300
GQKANNWGSP YKSNGCGMVF PQNSHLASHQ RSHTKEKPYK CYECGKAFRT
310 320 330 340 350
RSNLTTHQVI HTGEKRYKCN ECGKVFSRNS QLSQHQKIHT GEKPYKCNEC
360 370 380 390 400
GKVFTQNSHL VRHRGIHTGE KPYKCNECGK AFRARSSLAI HQATHSGEKP
410 420 430 440 450
YKCNECGKVF TQNSHLTNHW RIHTGEKPYK CNECGKAFGV RSSLAIHLVI
460 470 480 490 500
HTGEKPYKCH ECGKVFRRNS HLARHQLIHT GEKPYKCNEC GKAFRAHSNL
510 520 530 540 550
TTHQVIHTGE KPYKCNECGK VFTQNSHLAN HQRIHTGVKP YMCNECGKAF
560 570 580 590 600
SVYSSLTTHQ VIHTGEKPYK CNECGKVFTQ NSHLARHRGI HTGEKPYKCN
610 620 630 640 650
ECGKVFRHNS YLSRHQRIHT GEKPYKYNEY GKAFSEHSNL TTHQVIHTGE
660 670 680 690 700
KPYKCNECGK VFTQNSHLAR HRRVHTGGKP YQCNECGKAF SQTSKLARHQ
710 720 730 740 750
RVHTGEKPYE CNQCGKAFSV RSSLTTHQAI HTGKKPYKCN ECGKVFTQNS
760 770 780 790 800
HLARHRGIHT GEKPYKCNEC GKAFSQTSKL ARHQRIHTGE KPYECGKPFS
810 820 830
ICSSLTTHQT IHTGGKPYKC NVWKVLKSEF KPCKPSQNS
Length:839
Mass (Da):95,770
Last modified:May 18, 2010 - v2
Checksum:iC951647ECF4D644D
GO
Isoform 2 (identifier: Q96SE7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-47: L → LA

Note: No experimental confirmation available.
Show »
Length:840
Mass (Da):95,841
Checksum:i22CAD154FA4607FB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti215N → D in BAG53339 (PubMed:14702039).Curated1
Sequence conflicti253K → R in BAG53339 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052815117M → V.Corresponds to variant rs34656962dbSNPEnsembl.1
Natural variantiVAR_059913264N → D.3 PublicationsCorresponds to variant rs2195310dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04684147L → LA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029765 mRNA. Translation: AAK37403.1.
AK096623 mRNA. Translation: BAG53339.1.
AC010328 Genomic DNA. No translation available.
AC092070 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72119.1.
BC136255 mRNA. Translation: AAI36256.1.
AL713691 mRNA. Translation: CAD28491.1.
CCDSiCCDS33097.1. [Q96SE7-1]
CCDS54314.1. [Q96SE7-2]
RefSeqiNP_001166145.1. NM_001172674.1. [Q96SE7-2]
NP_001166146.1. NM_001172675.1. [Q96SE7-2]
NP_115973.2. NM_032584.2. [Q96SE7-1]
XP_005259392.1. XM_005259335.4. [Q96SE7-1]
XP_016882873.1. XM_017027384.1. [Q96SE7-1]
UniGeneiHs.467239.

Genome annotation databases

EnsembliENST00000334197; ENSP00000334146; ENSG00000197937. [Q96SE7-1]
ENST00000452676; ENSP00000405218; ENSG00000197937. [Q96SE7-2]
ENST00000601469; ENSP00000471712; ENSG00000197937. [Q96SE7-2]
GeneIDi84671.
KEGGihsa:84671.
UCSCiuc002qbb.3. human. [Q96SE7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029765 mRNA. Translation: AAK37403.1.
AK096623 mRNA. Translation: BAG53339.1.
AC010328 Genomic DNA. No translation available.
AC092070 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72119.1.
BC136255 mRNA. Translation: AAI36256.1.
AL713691 mRNA. Translation: CAD28491.1.
CCDSiCCDS33097.1. [Q96SE7-1]
CCDS54314.1. [Q96SE7-2]
RefSeqiNP_001166145.1. NM_001172674.1. [Q96SE7-2]
NP_001166146.1. NM_001172675.1. [Q96SE7-2]
NP_115973.2. NM_032584.2. [Q96SE7-1]
XP_005259392.1. XM_005259335.4. [Q96SE7-1]
XP_016882873.1. XM_017027384.1. [Q96SE7-1]
UniGeneiHs.467239.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EMANMR-A312-344[»]
2EMPNMR-A536-568[»]
2EN4NMR-A284-316[»]
2ENENMR-A592-624[»]
2ENFNMR-A340-372[»]
2EOENMR-A508-540[»]
2EOWNMR-A368-400[»]
2EQ0NMR-A452-484[»]
2EQ1NMR-A480-512[»]
2EQ2NMR-A676-708[»]
2EQ3NMR-A704-736[»]
2YTINMR-A564-596[»]
2YTKNMR-A396-428[»]
2YTNNMR-A732-764[»]
2YTRNMR-A760-792[»]
2YU8NMR-A648-680[»]
ProteinModelPortaliQ96SE7.
SMRiQ96SE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96SE7. 1 interactor.
STRINGi9606.ENSP00000405218.

PTM databases

iPTMnetiQ96SE7.
PhosphoSitePlusiQ96SE7.

Polymorphism and mutation databases

BioMutaiZNF347.
DMDMi296453051.

Proteomic databases

EPDiQ96SE7.
MaxQBiQ96SE7.
PaxDbiQ96SE7.
PeptideAtlasiQ96SE7.
PRIDEiQ96SE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334197; ENSP00000334146; ENSG00000197937. [Q96SE7-1]
ENST00000452676; ENSP00000405218; ENSG00000197937. [Q96SE7-2]
ENST00000601469; ENSP00000471712; ENSG00000197937. [Q96SE7-2]
GeneIDi84671.
KEGGihsa:84671.
UCSCiuc002qbb.3. human. [Q96SE7-1]

Organism-specific databases

CTDi84671.
GeneCardsiZNF347.
HGNCiHGNC:16447. ZNF347.
HPAiHPA023448.
neXtProtiNX_Q96SE7.
OpenTargetsiENSG00000197937.
PharmGKBiPA38143.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96SE7.
KOiK09228.
OMAiKSNGCGM.
PhylomeDBiQ96SE7.
TreeFamiTF341892.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170949-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF347. human.
EvolutionaryTraceiQ96SE7.
GenomeRNAii84671.
PROiQ96SE7.

Gene expression databases

BgeeiENSG00000197937.
CleanExiHS_ZNF347.
ExpressionAtlasiQ96SE7. baseline and differential.
GenevisibleiQ96SE7. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 20 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 13 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 20 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN347_HUMAN
AccessioniPrimary (citable) accession number: Q96SE7
Secondary accession number(s): B3KU77
, B9EG59, G5E9N4, Q8TCN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.