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Protein

Doublesex- and mab-3-related transcription factor A2

Gene

DMRTA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in sexual development.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Doublesex- and mab-3-related transcription factor A2
Alternative name(s):
Doublesex- and mab-3-related transcription factor 5
Gene namesi
Name:DMRTA2
Synonyms:DMRT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:13908. DMRTA2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27385.

Polymorphism and mutation databases

BioMutaiDMRTA2.
DMDMi189044724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Doublesex- and mab-3-related transcription factor A2PRO_0000333772Add
BLAST

Proteomic databases

PaxDbiQ96SC8.
PeptideAtlasiQ96SC8.
PRIDEiQ96SC8.

PTM databases

iPTMnetiQ96SC8.
PhosphoSiteiQ96SC8.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000142700.
CleanExiHS_DMRTA2.
GenevisibleiQ96SC8. HS.

Organism-specific databases

HPAiHPA043098.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000383909.

Structurei

3D structure databases

ProteinModelPortaliQ96SC8.
SMRiQ96SC8. Positions 65-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi13 – 4028Ala-richAdd
BLAST
Compositional biasi165 – 363199Gly-richAdd
BLAST
Compositional biasi359 – 519161Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the DMRT family.Curated
Contains 1 DM DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3815. Eukaryota.
ENOG410XSK9. LUCA.
GeneTreeiENSGT00550000074486.
HOGENOMiHOG000231615.
HOVERGENiHBG058695.
InParanoidiQ96SC8.
KOiK19491.
OMAiDDAWPGR.
OrthoDBiEOG091G0K2L.
PhylomeDBiQ96SC8.
TreeFamiTF317837.

Family and domain databases

Gene3Di4.10.1040.10. 1 hit.
InterProiIPR001275. DM_DNA-bd.
IPR005173. DMA.
IPR026607. DMRT/dsx/mab-3.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR12322. PTHR12322. 1 hit.
PfamiPF00751. DM. 1 hit.
PF03474. DMA. 1 hit.
[Graphical view]
SMARTiSM00301. DM. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF82927. SSF82927. 1 hit.
PROSITEiPS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96SC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRSELPSV PGAATAAAAT ATGPPVASVA SVAAAAAAAA SLPVSVAGGL
60 70 80 90 100
LRGPPLLLRA AEKYPRTPKC ARCRNHGVVS ALKGHKRYCR WKDCLCAKCT
110 120 130 140 150
LIAERQRVMA AQVALRRQQA QEENEARELQ LLYGTAEGLA LAAANGIIPP
160 170 180 190 200
RPAYEVFGSV CAADGGGPGA GAPAGTGGGA AGAGGSEAKL QKFDLFPKTL
210 220 230 240 250
LQAGRPGSPL PPPVKPLSPD GADSGPGTSS PEVRPGSGSE NGDGESFSGS
260 270 280 290 300
PLARASKEAG GSCPGSAGPG GGGEEDSPGS ASPLGSESGS EADKEEGEAA
310 320 330 340 350
PAPGLGGGSG PRQRTPLDIL TRVFPGHRRG VLELVLQGCG GDVVQAIEQV
360 370 380 390 400
LNHHRGGLAA GLGPAAPPDK AAVGAAAAAD DAWPSRVDAA AAAAAAAGGP
410 420 430 440 450
GLPAPLQAGP AAPPHHRPLL AGAMAPGALG SLSSRSAFSP LQPNASHFGA
460 470 480 490 500
DAGAYPLGAP LGLSPLRLAY SAAAAHSRGL AFMAPYSTAG LVPTLGFRPP
510 520 530 540
MDYAFSDLMR DRSAAAAAAV HKEPTYGGGL YGPMVNGAPE KQ
Length:542
Mass (Da):53,356
Last modified:May 20, 2008 - v2
Checksum:i1ADA8CE1D2D9C76B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049637 Genomic DNA. No translation available.
AJ301580 mRNA. Translation: CAC37946.1.
CCDSiCCDS44141.1.
RefSeqiNP_115486.1. NM_032110.2.
XP_011540239.1. XM_011541937.2.
UniGeneiHs.334481.

Genome annotation databases

EnsembliENST00000404795; ENSP00000383909; ENSG00000142700.
ENST00000418121; ENSP00000399370; ENSG00000142700.
GeneIDi63950.
KEGGihsa:63950.
UCSCiuc010ona.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049637 Genomic DNA. No translation available.
AJ301580 mRNA. Translation: CAC37946.1.
CCDSiCCDS44141.1.
RefSeqiNP_115486.1. NM_032110.2.
XP_011540239.1. XM_011541937.2.
UniGeneiHs.334481.

3D structure databases

ProteinModelPortaliQ96SC8.
SMRiQ96SC8. Positions 65-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000383909.

PTM databases

iPTMnetiQ96SC8.
PhosphoSiteiQ96SC8.

Polymorphism and mutation databases

BioMutaiDMRTA2.
DMDMi189044724.

Proteomic databases

PaxDbiQ96SC8.
PeptideAtlasiQ96SC8.
PRIDEiQ96SC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404795; ENSP00000383909; ENSG00000142700.
ENST00000418121; ENSP00000399370; ENSG00000142700.
GeneIDi63950.
KEGGihsa:63950.
UCSCiuc010ona.3. human.

Organism-specific databases

CTDi63950.
GeneCardsiDMRTA2.
H-InvDBHIX0028628.
HGNCiHGNC:13908. DMRTA2.
HPAiHPA043098.
MIMi614804. gene.
neXtProtiNX_Q96SC8.
PharmGKBiPA27385.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3815. Eukaryota.
ENOG410XSK9. LUCA.
GeneTreeiENSGT00550000074486.
HOGENOMiHOG000231615.
HOVERGENiHBG058695.
InParanoidiQ96SC8.
KOiK19491.
OMAiDDAWPGR.
OrthoDBiEOG091G0K2L.
PhylomeDBiQ96SC8.
TreeFamiTF317837.

Miscellaneous databases

GenomeRNAii63950.
PROiQ96SC8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142700.
CleanExiHS_DMRTA2.
GenevisibleiQ96SC8. HS.

Family and domain databases

Gene3Di4.10.1040.10. 1 hit.
InterProiIPR001275. DM_DNA-bd.
IPR005173. DMA.
IPR026607. DMRT/dsx/mab-3.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR12322. PTHR12322. 1 hit.
PfamiPF00751. DM. 1 hit.
PF03474. DMA. 1 hit.
[Graphical view]
SMARTiSM00301. DM. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF82927. SSF82927. 1 hit.
PROSITEiPS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDMTA2_HUMAN
AccessioniPrimary (citable) accession number: Q96SC8
Secondary accession number(s): Q5TFQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.