Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Doublesex- and mab-3-related transcription factor A2

Gene

DMRTA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in sexual development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi70 – 117DMPROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Doublesex- and mab-3-related transcription factor A2
Alternative name(s):
Doublesex- and mab-3-related transcription factor 5
Gene namesi
Name:DMRTA2
Synonyms:DMRT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142700.11
HGNCiHGNC:13908 DMRTA2
MIMi614804 gene
neXtProtiNX_Q96SC8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142700
PharmGKBiPA27385

Polymorphism and mutation databases

BioMutaiDMRTA2
DMDMi189044724

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003337721 – 542Doublesex- and mab-3-related transcription factor A2Add BLAST542

Proteomic databases

PaxDbiQ96SC8
PeptideAtlasiQ96SC8
PRIDEiQ96SC8

PTM databases

iPTMnetiQ96SC8
PhosphoSitePlusiQ96SC8

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000142700
CleanExiHS_DMRTA2
GenevisibleiQ96SC8 HS

Organism-specific databases

HPAiHPA043098
HPA062958

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000383909

Structurei

3D structure databases

ProteinModelPortaliQ96SC8
SMRiQ96SC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 40Ala-richAdd BLAST28
Compositional biasi165 – 363Gly-richAdd BLAST199
Compositional biasi359 – 519Ala-richAdd BLAST161

Sequence similaritiesi

Belongs to the DMRT family.Curated

Phylogenomic databases

eggNOGiKOG3815 Eukaryota
ENOG410XSK9 LUCA
GeneTreeiENSGT00550000074486
HOGENOMiHOG000231615
HOVERGENiHBG058695
InParanoidiQ96SC8
KOiK19491
OMAiPDKAAVG
OrthoDBiEOG091G0K2L
PhylomeDBiQ96SC8
TreeFamiTF317837

Family and domain databases

Gene3Di4.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR001275 DM_DNA-bd
IPR036407 DM_DNA-bd_sf
IPR005173 DMA
IPR026607 DMRT/dsx/mab-3
IPR009060 UBA-like_sf
PANTHERiPTHR12322 PTHR12322, 1 hit
PfamiView protein in Pfam
PF00751 DM, 1 hit
PF03474 DMA, 1 hit
SMARTiView protein in SMART
SM00301 DM, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF82927 SSF82927, 1 hit
PROSITEiView protein in PROSITE
PS40000 DM_1, 1 hit
PS50809 DM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96SC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRSELPSV PGAATAAAAT ATGPPVASVA SVAAAAAAAA SLPVSVAGGL
60 70 80 90 100
LRGPPLLLRA AEKYPRTPKC ARCRNHGVVS ALKGHKRYCR WKDCLCAKCT
110 120 130 140 150
LIAERQRVMA AQVALRRQQA QEENEARELQ LLYGTAEGLA LAAANGIIPP
160 170 180 190 200
RPAYEVFGSV CAADGGGPGA GAPAGTGGGA AGAGGSEAKL QKFDLFPKTL
210 220 230 240 250
LQAGRPGSPL PPPVKPLSPD GADSGPGTSS PEVRPGSGSE NGDGESFSGS
260 270 280 290 300
PLARASKEAG GSCPGSAGPG GGGEEDSPGS ASPLGSESGS EADKEEGEAA
310 320 330 340 350
PAPGLGGGSG PRQRTPLDIL TRVFPGHRRG VLELVLQGCG GDVVQAIEQV
360 370 380 390 400
LNHHRGGLAA GLGPAAPPDK AAVGAAAAAD DAWPSRVDAA AAAAAAAGGP
410 420 430 440 450
GLPAPLQAGP AAPPHHRPLL AGAMAPGALG SLSSRSAFSP LQPNASHFGA
460 470 480 490 500
DAGAYPLGAP LGLSPLRLAY SAAAAHSRGL AFMAPYSTAG LVPTLGFRPP
510 520 530 540
MDYAFSDLMR DRSAAAAAAV HKEPTYGGGL YGPMVNGAPE KQ
Length:542
Mass (Da):53,356
Last modified:May 20, 2008 - v2
Checksum:i1ADA8CE1D2D9C76B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049637 Genomic DNA No translation available.
AJ301580 mRNA Translation: CAC37946.1
CCDSiCCDS44141.1
RefSeqiNP_115486.1, NM_032110.2
XP_011540239.1, XM_011541937.2
UniGeneiHs.334481

Genome annotation databases

EnsembliENST00000404795; ENSP00000383909; ENSG00000142700
ENST00000418121; ENSP00000399370; ENSG00000142700
GeneIDi63950
KEGGihsa:63950
UCSCiuc010ona.3 human

Similar proteinsi

Entry informationi

Entry nameiDMTA2_HUMAN
AccessioniPrimary (citable) accession number: Q96SC8
Secondary accession number(s): Q5TFQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: March 28, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health