ID   SERC2_HUMAN             Reviewed;         455 AA.
AC   Q96SA4; A0AVB4; B4DJK5; B7Z567; B7ZAP2; E7EUZ9; Q86Y23;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 3.
DT   24-JAN-2024, entry version 159.
DE   RecName: Full=Serine incorporator 2;
DE   AltName: Full=Tumor differentially expressed protein 2-like;
GN   Name=SERINC2; Synonyms=TDE2L; ORFNames=FKSG84, UNQ263/PRO300;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Wang Y.-G., Gong L.;
RT   "Cloning and characterization of FKSG84, a novel gene located on human
RT   chromosome 1.";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Li N., Zhang W., Wan T., Cao X.;
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC   TISSUE=Mammary gland;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q96SA4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96SA4-2; Sequence=VSP_042464;
CC       Name=3;
CC         IsoId=Q96SA4-3; Sequence=VSP_042463;
CC       Name=4;
CC         IsoId=Q96SA4-4; Sequence=VSP_046840;
CC   -!- SIMILARITY: Belongs to the TDE1 family. {ECO:0000305}.
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DR   EMBL; AF352325; AAK83284.1; -; mRNA.
DR   EMBL; AY094595; AAM22522.1; -; mRNA.
DR   EMBL; AY358560; AAQ88924.1; -; mRNA.
DR   EMBL; AK298512; BAH12803.1; -; mRNA.
DR   EMBL; AK316357; BAH14728.1; -; mRNA.
DR   EMBL; AK296118; BAG58867.1; -; mRNA.
DR   EMBL; AC114494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC084580; AAH84580.1; -; mRNA.
DR   EMBL; BC126283; AAI26284.1; -; mRNA.
DR   EMBL; BC126285; AAI26286.1; -; mRNA.
DR   CCDS; CCDS30662.1; -. [Q96SA4-1]
DR   CCDS; CCDS55583.1; -. [Q96SA4-4]
DR   CCDS; CCDS55584.1; -. [Q96SA4-3]
DR   CCDS; CCDS55585.1; -. [Q96SA4-2]
DR   RefSeq; NP_001185966.1; NM_001199037.1. [Q96SA4-3]
DR   RefSeq; NP_001185967.1; NM_001199038.1. [Q96SA4-4]
DR   RefSeq; NP_001185968.1; NM_001199039.1.
DR   RefSeq; NP_061035.2; NM_018565.3. [Q96SA4-2]
DR   RefSeq; NP_849196.2; NM_178865.4. [Q96SA4-1]
DR   AlphaFoldDB; Q96SA4; -.
DR   SMR; Q96SA4; -.
DR   BioGRID; 131485; 58.
DR   IntAct; Q96SA4; 5.
DR   STRING; 9606.ENSP00000362814; -.
DR   iPTMnet; Q96SA4; -.
DR   PhosphoSitePlus; Q96SA4; -.
DR   BioMuta; SERINC2; -.
DR   DMDM; 380865453; -.
DR   MassIVE; Q96SA4; -.
DR   PaxDb; 9606-ENSP00000362814; -.
DR   PeptideAtlas; Q96SA4; -.
DR   ProteomicsDB; 18537; -.
DR   ProteomicsDB; 78094; -. [Q96SA4-1]
DR   ProteomicsDB; 78095; -. [Q96SA4-2]
DR   ProteomicsDB; 78096; -. [Q96SA4-3]
DR   Antibodypedia; 31115; 200 antibodies from 27 providers.
DR   DNASU; 347735; -.
DR   Ensembl; ENST00000373709.8; ENSP00000362813.3; ENSG00000168528.12. [Q96SA4-1]
DR   Ensembl; ENST00000373710.5; ENSP00000362814.1; ENSG00000168528.12. [Q96SA4-4]
DR   Ensembl; ENST00000536384.2; ENSP00000439048.1; ENSG00000168528.12. [Q96SA4-2]
DR   Ensembl; ENST00000536859.5; ENSP00000444307.1; ENSG00000168528.12. [Q96SA4-3]
DR   GeneID; 347735; -.
DR   KEGG; hsa:347735; -.
DR   MANE-Select; ENST00000373709.8; ENSP00000362813.3; NM_178865.5; NP_849196.2.
DR   UCSC; uc001bst.4; human. [Q96SA4-1]
DR   AGR; HGNC:23231; -.
DR   CTD; 347735; -.
DR   DisGeNET; 347735; -.
DR   GeneCards; SERINC2; -.
DR   HGNC; HGNC:23231; SERINC2.
DR   HPA; ENSG00000168528; Tissue enhanced (liver).
DR   MIM; 614549; gene.
DR   neXtProt; NX_Q96SA4; -.
DR   OpenTargets; ENSG00000168528; -.
DR   PharmGKB; PA134933002; -.
DR   VEuPathDB; HostDB:ENSG00000168528; -.
DR   eggNOG; KOG2592; Eukaryota.
DR   GeneTree; ENSGT01030000234623; -.
DR   HOGENOM; CLU_029574_5_0_1; -.
DR   InParanoid; Q96SA4; -.
DR   OMA; WYRPDES; -.
DR   OrthoDB; 53161at2759; -.
DR   TreeFam; TF312881; -.
DR   PathwayCommons; Q96SA4; -.
DR   Reactome; R-HSA-977347; Serine biosynthesis.
DR   SignaLink; Q96SA4; -.
DR   BioGRID-ORCS; 347735; 14 hits in 1150 CRISPR screens.
DR   ChiTaRS; SERINC2; human.
DR   GenomeRNAi; 347735; -.
DR   Pharos; Q96SA4; Tbio.
DR   PRO; PR:Q96SA4; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q96SA4; Protein.
DR   Bgee; ENSG00000168528; Expressed in mucosa of transverse colon and 130 other cell types or tissues.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   InterPro; IPR005016; TDE1/TMS.
DR   PANTHER; PTHR10383; SERINE INCORPORATOR; 1.
DR   PANTHER; PTHR10383:SF22; SERINE INCORPORATOR 2; 1.
DR   Pfam; PF03348; Serinc; 1.
DR   Genevisible; Q96SA4; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..455
FT                   /note="Serine incorporator 2"
FT                   /id="PRO_0000218968"
FT   TRANSMEM        5..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        385..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..13
FT                   /note="MGACLGACSLLSC -> MRSMRLREEESPGPSHT (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_042463"
FT   VAR_SEQ         1..13
FT                   /note="MGACLGACSLLSC -> MDGRMMRSMRLREEESPGPSHT (in isoform
FT                   4)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_046840"
FT   VAR_SEQ         4..13
FT                   /note="CLGACSLLSC -> EGAPDFLSCPRVRR (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_042464"
FT   VARIANT         303
FT                   /note="G -> S (in dbSNP:rs34728687)"
FT                   /id="VAR_061838"
FT   CONFLICT        4
FT                   /note="C -> L (in Ref. 1; AAK83284)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        81
FT                   /note="V -> A (in Ref. 4; BAH14728)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        98
FT                   /note="Y -> H (in Ref. 4; BAH14728)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        111
FT                   /note="F -> FF (in Ref. 3; AAQ88924)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        368
FT                   /note="Q -> QQ (in Ref. 1; AAK83284, 2; AAM22522, 3;
FT                   AAQ88924, 4; BAH12803/BAH14728 and 6;
FT                   AAH84580/AAI26284/AAI26286)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        382
FT                   /note="D -> G (in Ref. 4; BAH14728)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        451
FT                   /note="N -> K (in Ref. 1; AAK83284)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   455 AA;  50742 MW;  D18D21B535C7A73C CRC64;
     MGACLGACSL LSCASCLCGS APCILCSCCP ASRNSTVSRL IFTFFLFLGV LVSIIMLSPG
     VESQLYKLPW VCEEGAGIPT VLQGHIDCGS LLGYRAVYRM CFATAAFFFF FTLLMLCVSS
     SRDPRAAIQN GFWFFKFLIL VGLTVGAFYI PDGSFTNIWF YFGVVGSFLF ILIQLVLLID
     FAHSWNQRWL GKAEECDSRA WYAGLFFFTL LFYLLSIAAV ALMFMYYTEP SGCHEGKVFI
     SLNLTFCVCV SIAAVLPKVQ DAQPNSGLLQ ASVITLYTMF VTWSALSSIP EQKCNPHLPT
     QLGNETVVAG PEGYETQWWD APSIVGLIIF LLCTLFISLR SSDHRQVNSL MQTEECPPML
     DATQQQQQVA ACEGRAFDNE QDGVTYSYSF FHFCLVLASL HVMMTLTNWY KPGETRKMIS
     TWTAVWVKIC ASWAGLLLYL WTLVAPLLLR NRDFS
//