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Q96SA4 (SERC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine incorporator 2
Alternative name(s):
Tumor differentially expressed protein 2-like
Gene names
Name:SERINC2
Synonyms:TDE2L
ORF Names:FKSG84, UNQ263/PRO300
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TDE1 family.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96SA4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96SA4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     4-13: CLGACSLLSC → EGAPDFLSCPRVRR
Isoform 3 (identifier: Q96SA4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MGACLGACSLLSC → MRSMRLREEESPGPSHT
Isoform 4 (identifier: Q96SA4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MGACLGACSLLSC → MDGRMMRSMRLREEESPGPSHT
Note: No experimental confirmation available. Gene prediction based on cDNA data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Serine incorporator 2
PRO_0000218968

Regions

Transmembrane5 – 2723Helical; Potential
Transmembrane40 – 5718Helical; Potential
Transmembrane96 – 11823Helical; Potential
Transmembrane131 – 15020Helical; Potential
Transmembrane160 – 18223Helical; Potential
Transmembrane202 – 22423Helical; Potential
Transmembrane239 – 25618Helical; Potential
Transmembrane268 – 29023Helical; Potential
Transmembrane317 – 33923Helical; Potential
Transmembrane385 – 40723Helical; Potential
Transmembrane422 – 44423Helical; Potential

Natural variations

Alternative sequence1 – 1313MGACL…SLLSC → MRSMRLREEESPGPSHT in isoform 3.
VSP_042463
Alternative sequence1 – 1313MGACL…SLLSC → MDGRMMRSMRLREEESPGPS HT in isoform 4.
VSP_046840
Alternative sequence4 – 1310CLGACSLLSC → EGAPDFLSCPRVRR in isoform 2.
VSP_042464
Natural variant3031G → S.
Corresponds to variant rs34728687 [ dbSNP | Ensembl ].
VAR_061838

Experimental info

Sequence conflict41C → L in AAK83284. Ref.1
Sequence conflict811V → A in BAH14728. Ref.4
Sequence conflict981Y → H in BAH14728. Ref.4
Sequence conflict1111F → FF in AAQ88924. Ref.3
Sequence conflict3681Q → QQ in AAK83284. Ref.1
Sequence conflict3681Q → QQ in AAM22522. Ref.2
Sequence conflict3681Q → QQ in AAQ88924. Ref.3
Sequence conflict3681Q → QQ in BAH12803. Ref.4
Sequence conflict3681Q → QQ in BAH14728. Ref.4
Sequence conflict3681Q → QQ in AAH84580. Ref.6
Sequence conflict3681Q → QQ in AAI26284. Ref.6
Sequence conflict3681Q → QQ in AAI26286. Ref.6
Sequence conflict3821D → G in BAH14728. Ref.4
Sequence conflict4511N → K in AAK83284. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 21, 2012. Version 3.
Checksum: D18D21B535C7A73C

FASTA45550,742
        10         20         30         40         50         60 
MGACLGACSL LSCASCLCGS APCILCSCCP ASRNSTVSRL IFTFFLFLGV LVSIIMLSPG 

        70         80         90        100        110        120 
VESQLYKLPW VCEEGAGIPT VLQGHIDCGS LLGYRAVYRM CFATAAFFFF FTLLMLCVSS 

       130        140        150        160        170        180 
SRDPRAAIQN GFWFFKFLIL VGLTVGAFYI PDGSFTNIWF YFGVVGSFLF ILIQLVLLID 

       190        200        210        220        230        240 
FAHSWNQRWL GKAEECDSRA WYAGLFFFTL LFYLLSIAAV ALMFMYYTEP SGCHEGKVFI 

       250        260        270        280        290        300 
SLNLTFCVCV SIAAVLPKVQ DAQPNSGLLQ ASVITLYTMF VTWSALSSIP EQKCNPHLPT 

       310        320        330        340        350        360 
QLGNETVVAG PEGYETQWWD APSIVGLIIF LLCTLFISLR SSDHRQVNSL MQTEECPPML 

       370        380        390        400        410        420 
DATQQQQQVA ACEGRAFDNE QDGVTYSYSF FHFCLVLASL HVMMTLTNWY KPGETRKMIS 

       430        440        450 
TWTAVWVKIC ASWAGLLLYL WTLVAPLLLR NRDFS 

« Hide

Isoform 2 [UniParc].

Checksum: C65C9FA7E5A3C538
Show »

FASTA45951,376
Isoform 3 [UniParc].

Checksum: 49BD4F82611E3CFF
Show »

FASTA45951,514
Isoform 4 [UniParc].

Checksum: 15645E0FC8E3677D
Show »

FASTA46452,105

References

« Hide 'large scale' references
[1]"Cloning and characterization of FKSG84, a novel gene located on human chromosome 1."
Wang Y.-G., Gong L.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]Li N., Zhang W., Wan T., Cao X.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Mammary gland.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF352325 mRNA. Translation: AAK83284.1.
AY094595 mRNA. Translation: AAM22522.1.
AY358560 mRNA. Translation: AAQ88924.1.
AK298512 mRNA. Translation: BAH12803.1.
AK316357 mRNA. Translation: BAH14728.1.
AK296118 mRNA. Translation: BAG58867.1.
AC114494 Genomic DNA. No translation available.
BC084580 mRNA. Translation: AAH84580.1.
BC126283 mRNA. Translation: AAI26284.1.
BC126285 mRNA. Translation: AAI26286.1.
CCDSCCDS30662.1. [Q96SA4-1]
CCDS55583.1. [Q96SA4-4]
CCDS55584.1. [Q96SA4-3]
CCDS55585.1. [Q96SA4-2]
RefSeqNP_001185966.1. NM_001199037.1. [Q96SA4-3]
NP_001185967.1. NM_001199038.1. [Q96SA4-4]
NP_001185968.1. NM_001199039.1.
NP_061035.2. NM_018565.3. [Q96SA4-2]
NP_849196.2. NM_178865.4. [Q96SA4-1]
UniGeneHs.270655.

3D structure databases

ProteinModelPortalQ96SA4.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ96SA4.

Polymorphism databases

DMDM380865453.

Proteomic databases

PaxDbQ96SA4.
PRIDEQ96SA4.

Protocols and materials databases

DNASU347735.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373709; ENSP00000362813; ENSG00000168528. [Q96SA4-1]
ENST00000373710; ENSP00000362814; ENSG00000168528. [Q96SA4-4]
ENST00000536384; ENSP00000439048; ENSG00000168528. [Q96SA4-2]
ENST00000536859; ENSP00000444307; ENSG00000168528. [Q96SA4-3]
ENST00000562991; ENSP00000455650; ENSG00000260384. [Q96SA4-4]
ENST00000564235; ENSP00000455505; ENSG00000260384. [Q96SA4-1]
GeneID347735.
KEGGhsa:347735.
UCSCuc001bst.3. human. [Q96SA4-1]
uc010ogg.2. human. [Q96SA4-3]
uc010ogh.2. human. [Q96SA4-2]

Organism-specific databases

CTD347735.
GeneCardsGC01P031883.
H-InvDBHIX0000354.
HGNCHGNC:23231. SERINC2.
HPAHPA005974.
MIM614549. gene.
neXtProtNX_Q96SA4.
PharmGKBPA134933002.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG308011.
HOGENOMHOG000165463.
HOVERGENHBG025699.
OMAKCNPHLP.
OrthoDBEOG7TXKGQ.
TreeFamTF312881.

Gene expression databases

ArrayExpressQ96SA4.
BgeeQ96SA4.
GenevestigatorQ96SA4.

Family and domain databases

InterProIPR005016. TMS_TDE.
[Graphical view]
PANTHERPTHR10383. PTHR10383. 1 hit.
PfamPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi347735.
NextBio99270.
PROQ96SA4.
SOURCESearch...

Entry information

Entry nameSERC2_HUMAN
AccessionPrimary (citable) accession number: Q96SA4
Secondary accession number(s): A0AVB4 expand/collapse secondary AC list , B4DJK5, B7Z567, B7ZAP2, E7EUZ9, Q86Y23
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 21, 2012
Last modified: July 9, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM