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Q96SA4

- SERC2_HUMAN

UniProt

Q96SA4 - SERC2_HUMAN

Protein

Serine incorporator 2

Gene

SERINC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 3 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. phosphatidylserine metabolic process Source: Ensembl
    2. positive regulation of transferase activity Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine incorporator 2
    Alternative name(s):
    Tumor differentially expressed protein 2-like
    Gene namesi
    Name:SERINC2
    Synonyms:TDE2L
    ORF Names:FKSG84, UNQ263/PRO300
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:23231. SERINC2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134933002.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Serine incorporator 2PRO_0000218968Add
    BLAST

    Proteomic databases

    PaxDbiQ96SA4.
    PRIDEiQ96SA4.

    PTM databases

    PhosphoSiteiQ96SA4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96SA4.
    BgeeiQ96SA4.
    GenevestigatoriQ96SA4.

    Organism-specific databases

    HPAiHPA005974.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96SA4.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei40 – 5718HelicalSequence AnalysisAdd
    BLAST
    Transmembranei96 – 11823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25618HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 29023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei317 – 33923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei385 – 40723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei422 – 44423HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TDE1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG308011.
    HOGENOMiHOG000165463.
    HOVERGENiHBG025699.
    OMAiKCNPHLP.
    OrthoDBiEOG7TXKGQ.
    TreeFamiTF312881.

    Family and domain databases

    InterProiIPR029554. SERINC2.
    IPR005016. TDE1/TMS.
    [Graphical view]
    PANTHERiPTHR10383. PTHR10383. 1 hit.
    PTHR10383:SF22. PTHR10383:SF22. 1 hit.
    PfamiPF03348. Serinc. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96SA4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGACLGACSL LSCASCLCGS APCILCSCCP ASRNSTVSRL IFTFFLFLGV    50
    LVSIIMLSPG VESQLYKLPW VCEEGAGIPT VLQGHIDCGS LLGYRAVYRM 100
    CFATAAFFFF FTLLMLCVSS SRDPRAAIQN GFWFFKFLIL VGLTVGAFYI 150
    PDGSFTNIWF YFGVVGSFLF ILIQLVLLID FAHSWNQRWL GKAEECDSRA 200
    WYAGLFFFTL LFYLLSIAAV ALMFMYYTEP SGCHEGKVFI SLNLTFCVCV 250
    SIAAVLPKVQ DAQPNSGLLQ ASVITLYTMF VTWSALSSIP EQKCNPHLPT 300
    QLGNETVVAG PEGYETQWWD APSIVGLIIF LLCTLFISLR SSDHRQVNSL 350
    MQTEECPPML DATQQQQQVA ACEGRAFDNE QDGVTYSYSF FHFCLVLASL 400
    HVMMTLTNWY KPGETRKMIS TWTAVWVKIC ASWAGLLLYL WTLVAPLLLR 450
    NRDFS 455
    Length:455
    Mass (Da):50,742
    Last modified:March 21, 2012 - v3
    Checksum:iD18D21B535C7A73C
    GO
    Isoform 2 (identifier: Q96SA4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         4-13: CLGACSLLSC → EGAPDFLSCPRVRR

    Show »
    Length:459
    Mass (Da):51,376
    Checksum:iC65C9FA7E5A3C538
    GO
    Isoform 3 (identifier: Q96SA4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: MGACLGACSLLSC → MRSMRLREEESPGPSHT

    Show »
    Length:459
    Mass (Da):51,514
    Checksum:i49BD4F82611E3CFF
    GO
    Isoform 4 (identifier: Q96SA4-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: MGACLGACSLLSC → MDGRMMRSMRLREEESPGPSHT

    Note: No experimental confirmation available. Gene prediction based on cDNA data.

    Show »
    Length:464
    Mass (Da):52,105
    Checksum:i15645E0FC8E3677D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41C → L in AAK83284. 1 PublicationCurated
    Sequence conflicti81 – 811V → A in BAH14728. (PubMed:14702039)Curated
    Sequence conflicti98 – 981Y → H in BAH14728. (PubMed:14702039)Curated
    Sequence conflicti111 – 1111F → FF in AAQ88924. (PubMed:12975309)Curated
    Sequence conflicti368 – 3681Q → QQ in AAK83284. 1 PublicationCurated
    Sequence conflicti368 – 3681Q → QQ in AAM22522. 1 PublicationCurated
    Sequence conflicti368 – 3681Q → QQ in AAQ88924. (PubMed:12975309)Curated
    Sequence conflicti368 – 3681Q → QQ in BAH12803. (PubMed:14702039)Curated
    Sequence conflicti368 – 3681Q → QQ in BAH14728. (PubMed:14702039)Curated
    Sequence conflicti368 – 3681Q → QQ in AAH84580. (PubMed:15489334)Curated
    Sequence conflicti368 – 3681Q → QQ in AAI26284. (PubMed:15489334)Curated
    Sequence conflicti368 – 3681Q → QQ in AAI26286. (PubMed:15489334)Curated
    Sequence conflicti382 – 3821D → G in BAH14728. (PubMed:14702039)Curated
    Sequence conflicti451 – 4511N → K in AAK83284. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti303 – 3031G → S.
    Corresponds to variant rs34728687 [ dbSNP | Ensembl ].
    VAR_061838

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1313MGACL…SLLSC → MRSMRLREEESPGPSHT in isoform 3. 1 PublicationVSP_042463Add
    BLAST
    Alternative sequencei1 – 1313MGACL…SLLSC → MDGRMMRSMRLREEESPGPS HT in isoform 4. CuratedVSP_046840Add
    BLAST
    Alternative sequencei4 – 1310CLGACSLLSC → EGAPDFLSCPRVRR in isoform 2. 1 PublicationVSP_042464

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF352325 mRNA. Translation: AAK83284.1.
    AY094595 mRNA. Translation: AAM22522.1.
    AY358560 mRNA. Translation: AAQ88924.1.
    AK298512 mRNA. Translation: BAH12803.1.
    AK316357 mRNA. Translation: BAH14728.1.
    AK296118 mRNA. Translation: BAG58867.1.
    AC114494 Genomic DNA. No translation available.
    BC084580 mRNA. Translation: AAH84580.1.
    BC126283 mRNA. Translation: AAI26284.1.
    BC126285 mRNA. Translation: AAI26286.1.
    CCDSiCCDS30662.1. [Q96SA4-1]
    CCDS55583.1. [Q96SA4-4]
    CCDS55584.1. [Q96SA4-3]
    CCDS55585.1. [Q96SA4-2]
    RefSeqiNP_001185966.1. NM_001199037.1. [Q96SA4-3]
    NP_001185967.1. NM_001199038.1. [Q96SA4-4]
    NP_001185968.1. NM_001199039.1.
    NP_061035.2. NM_018565.3. [Q96SA4-2]
    NP_849196.2. NM_178865.4. [Q96SA4-1]
    UniGeneiHs.270655.

    Genome annotation databases

    EnsembliENST00000373709; ENSP00000362813; ENSG00000168528. [Q96SA4-1]
    ENST00000373710; ENSP00000362814; ENSG00000168528. [Q96SA4-4]
    ENST00000536384; ENSP00000439048; ENSG00000168528. [Q96SA4-2]
    ENST00000536859; ENSP00000444307; ENSG00000168528. [Q96SA4-3]
    GeneIDi347735.
    KEGGihsa:347735.
    UCSCiuc001bst.3. human. [Q96SA4-1]
    uc010ogg.2. human. [Q96SA4-3]
    uc010ogh.2. human. [Q96SA4-2]

    Polymorphism databases

    DMDMi380865453.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF352325 mRNA. Translation: AAK83284.1 .
    AY094595 mRNA. Translation: AAM22522.1 .
    AY358560 mRNA. Translation: AAQ88924.1 .
    AK298512 mRNA. Translation: BAH12803.1 .
    AK316357 mRNA. Translation: BAH14728.1 .
    AK296118 mRNA. Translation: BAG58867.1 .
    AC114494 Genomic DNA. No translation available.
    BC084580 mRNA. Translation: AAH84580.1 .
    BC126283 mRNA. Translation: AAI26284.1 .
    BC126285 mRNA. Translation: AAI26286.1 .
    CCDSi CCDS30662.1. [Q96SA4-1 ]
    CCDS55583.1. [Q96SA4-4 ]
    CCDS55584.1. [Q96SA4-3 ]
    CCDS55585.1. [Q96SA4-2 ]
    RefSeqi NP_001185966.1. NM_001199037.1. [Q96SA4-3 ]
    NP_001185967.1. NM_001199038.1. [Q96SA4-4 ]
    NP_001185968.1. NM_001199039.1.
    NP_061035.2. NM_018565.3. [Q96SA4-2 ]
    NP_849196.2. NM_178865.4. [Q96SA4-1 ]
    UniGenei Hs.270655.

    3D structure databases

    ProteinModelPortali Q96SA4.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q96SA4.

    Polymorphism databases

    DMDMi 380865453.

    Proteomic databases

    PaxDbi Q96SA4.
    PRIDEi Q96SA4.

    Protocols and materials databases

    DNASUi 347735.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373709 ; ENSP00000362813 ; ENSG00000168528 . [Q96SA4-1 ]
    ENST00000373710 ; ENSP00000362814 ; ENSG00000168528 . [Q96SA4-4 ]
    ENST00000536384 ; ENSP00000439048 ; ENSG00000168528 . [Q96SA4-2 ]
    ENST00000536859 ; ENSP00000444307 ; ENSG00000168528 . [Q96SA4-3 ]
    GeneIDi 347735.
    KEGGi hsa:347735.
    UCSCi uc001bst.3. human. [Q96SA4-1 ]
    uc010ogg.2. human. [Q96SA4-3 ]
    uc010ogh.2. human. [Q96SA4-2 ]

    Organism-specific databases

    CTDi 347735.
    GeneCardsi GC01P031883.
    H-InvDB HIX0000354.
    HGNCi HGNC:23231. SERINC2.
    HPAi HPA005974.
    MIMi 614549. gene.
    neXtProti NX_Q96SA4.
    PharmGKBi PA134933002.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308011.
    HOGENOMi HOG000165463.
    HOVERGENi HBG025699.
    OMAi KCNPHLP.
    OrthoDBi EOG7TXKGQ.
    TreeFami TF312881.

    Miscellaneous databases

    GenomeRNAii 347735.
    NextBioi 99270.
    PROi Q96SA4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96SA4.
    Bgeei Q96SA4.
    Genevestigatori Q96SA4.

    Family and domain databases

    InterProi IPR029554. SERINC2.
    IPR005016. TDE1/TMS.
    [Graphical view ]
    PANTHERi PTHR10383. PTHR10383. 1 hit.
    PTHR10383:SF22. PTHR10383:SF22. 1 hit.
    Pfami PF03348. Serinc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of FKSG84, a novel gene located on human chromosome 1."
      Wang Y.-G., Gong L.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Li N., Zhang W., Wan T., Cao X.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Mammary gland.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.

    Entry informationi

    Entry nameiSERC2_HUMAN
    AccessioniPrimary (citable) accession number: Q96SA4
    Secondary accession number(s): A0AVB4
    , B4DJK5, B7Z567, B7ZAP2, E7EUZ9, Q86Y23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 103 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3