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Q96SA4

- SERC2_HUMAN

UniProt

Q96SA4 - SERC2_HUMAN

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Protein

Serine incorporator 2

Gene

SERINC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. L-serine transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. phosphatidylserine metabolic process Source: Ensembl
  2. positive regulation of transferase activity Source: Ensembl
  3. sphingolipid metabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 2
Alternative name(s):
Tumor differentially expressed protein 2-like
Gene namesi
Name:SERINC2
Synonyms:TDE2L
ORF Names:FKSG84, UNQ263/PRO300
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:23231. SERINC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2723HelicalSequence AnalysisAdd
BLAST
Transmembranei40 – 5718HelicalSequence AnalysisAdd
BLAST
Transmembranei96 – 11823HelicalSequence AnalysisAdd
BLAST
Transmembranei131 – 15020HelicalSequence AnalysisAdd
BLAST
Transmembranei160 – 18223HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22423HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25618HelicalSequence AnalysisAdd
BLAST
Transmembranei268 – 29023HelicalSequence AnalysisAdd
BLAST
Transmembranei317 – 33923HelicalSequence AnalysisAdd
BLAST
Transmembranei385 – 40723HelicalSequence AnalysisAdd
BLAST
Transmembranei422 – 44423HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134933002.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Serine incorporator 2PRO_0000218968Add
BLAST

Proteomic databases

PaxDbiQ96SA4.
PRIDEiQ96SA4.

PTM databases

PhosphoSiteiQ96SA4.

Expressioni

Gene expression databases

BgeeiQ96SA4.
GenevestigatoriQ96SA4.

Organism-specific databases

HPAiHPA005974.

Interactioni

Protein-protein interaction databases

BioGridi131485. 8 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ96SA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308011.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ96SA4.
OMAiKCNPHLP.
OrthoDBiEOG7TXKGQ.
TreeFamiTF312881.

Family and domain databases

InterProiIPR029554. SERINC2.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF22. PTHR10383:SF22. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96SA4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGACLGACSL LSCASCLCGS APCILCSCCP ASRNSTVSRL IFTFFLFLGV
60 70 80 90 100
LVSIIMLSPG VESQLYKLPW VCEEGAGIPT VLQGHIDCGS LLGYRAVYRM
110 120 130 140 150
CFATAAFFFF FTLLMLCVSS SRDPRAAIQN GFWFFKFLIL VGLTVGAFYI
160 170 180 190 200
PDGSFTNIWF YFGVVGSFLF ILIQLVLLID FAHSWNQRWL GKAEECDSRA
210 220 230 240 250
WYAGLFFFTL LFYLLSIAAV ALMFMYYTEP SGCHEGKVFI SLNLTFCVCV
260 270 280 290 300
SIAAVLPKVQ DAQPNSGLLQ ASVITLYTMF VTWSALSSIP EQKCNPHLPT
310 320 330 340 350
QLGNETVVAG PEGYETQWWD APSIVGLIIF LLCTLFISLR SSDHRQVNSL
360 370 380 390 400
MQTEECPPML DATQQQQQVA ACEGRAFDNE QDGVTYSYSF FHFCLVLASL
410 420 430 440 450
HVMMTLTNWY KPGETRKMIS TWTAVWVKIC ASWAGLLLYL WTLVAPLLLR

NRDFS
Length:455
Mass (Da):50,742
Last modified:March 21, 2012 - v3
Checksum:iD18D21B535C7A73C
GO
Isoform 2 (identifier: Q96SA4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-13: CLGACSLLSC → EGAPDFLSCPRVRR

Show »
Length:459
Mass (Da):51,376
Checksum:iC65C9FA7E5A3C538
GO
Isoform 3 (identifier: Q96SA4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MGACLGACSLLSC → MRSMRLREEESPGPSHT

Show »
Length:459
Mass (Da):51,514
Checksum:i49BD4F82611E3CFF
GO
Isoform 4 (identifier: Q96SA4-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MGACLGACSLLSC → MDGRMMRSMRLREEESPGPSHT

Note: No experimental confirmation available. Gene prediction based on cDNA data.

Show »
Length:464
Mass (Da):52,105
Checksum:i15645E0FC8E3677D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41C → L in AAK83284. 1 PublicationCurated
Sequence conflicti81 – 811V → A in BAH14728. (PubMed:14702039)Curated
Sequence conflicti98 – 981Y → H in BAH14728. (PubMed:14702039)Curated
Sequence conflicti111 – 1111F → FF in AAQ88924. (PubMed:12975309)Curated
Sequence conflicti368 – 3681Q → QQ in AAK83284. 1 PublicationCurated
Sequence conflicti368 – 3681Q → QQ in AAM22522. 1 PublicationCurated
Sequence conflicti368 – 3681Q → QQ in AAQ88924. (PubMed:12975309)Curated
Sequence conflicti368 – 3681Q → QQ in BAH12803. (PubMed:14702039)Curated
Sequence conflicti368 – 3681Q → QQ in BAH14728. (PubMed:14702039)Curated
Sequence conflicti368 – 3681Q → QQ in AAH84580. (PubMed:15489334)Curated
Sequence conflicti368 – 3681Q → QQ in AAI26284. (PubMed:15489334)Curated
Sequence conflicti368 – 3681Q → QQ in AAI26286. (PubMed:15489334)Curated
Sequence conflicti382 – 3821D → G in BAH14728. (PubMed:14702039)Curated
Sequence conflicti451 – 4511N → K in AAK83284. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti303 – 3031G → S.
Corresponds to variant rs34728687 [ dbSNP | Ensembl ].
VAR_061838

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313MGACL…SLLSC → MRSMRLREEESPGPSHT in isoform 3. 1 PublicationVSP_042463Add
BLAST
Alternative sequencei1 – 1313MGACL…SLLSC → MDGRMMRSMRLREEESPGPS HT in isoform 4. CuratedVSP_046840Add
BLAST
Alternative sequencei4 – 1310CLGACSLLSC → EGAPDFLSCPRVRR in isoform 2. 1 PublicationVSP_042464

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352325 mRNA. Translation: AAK83284.1.
AY094595 mRNA. Translation: AAM22522.1.
AY358560 mRNA. Translation: AAQ88924.1.
AK298512 mRNA. Translation: BAH12803.1.
AK316357 mRNA. Translation: BAH14728.1.
AK296118 mRNA. Translation: BAG58867.1.
AC114494 Genomic DNA. No translation available.
BC084580 mRNA. Translation: AAH84580.1.
BC126283 mRNA. Translation: AAI26284.1.
BC126285 mRNA. Translation: AAI26286.1.
CCDSiCCDS30662.1. [Q96SA4-1]
CCDS55583.1. [Q96SA4-4]
CCDS55584.1. [Q96SA4-3]
CCDS55585.1. [Q96SA4-2]
RefSeqiNP_001185966.1. NM_001199037.1. [Q96SA4-3]
NP_001185967.1. NM_001199038.1. [Q96SA4-4]
NP_001185968.1. NM_001199039.1.
NP_061035.2. NM_018565.3. [Q96SA4-2]
NP_849196.2. NM_178865.4. [Q96SA4-1]
UniGeneiHs.270655.

Genome annotation databases

EnsembliENST00000373709; ENSP00000362813; ENSG00000168528. [Q96SA4-1]
ENST00000373710; ENSP00000362814; ENSG00000168528. [Q96SA4-4]
ENST00000536384; ENSP00000439048; ENSG00000168528. [Q96SA4-2]
ENST00000536859; ENSP00000444307; ENSG00000168528. [Q96SA4-3]
GeneIDi347735.
KEGGihsa:347735.
UCSCiuc001bst.3. human. [Q96SA4-1]
uc010ogg.2. human. [Q96SA4-3]
uc010ogh.2. human. [Q96SA4-2]

Polymorphism databases

DMDMi380865453.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352325 mRNA. Translation: AAK83284.1 .
AY094595 mRNA. Translation: AAM22522.1 .
AY358560 mRNA. Translation: AAQ88924.1 .
AK298512 mRNA. Translation: BAH12803.1 .
AK316357 mRNA. Translation: BAH14728.1 .
AK296118 mRNA. Translation: BAG58867.1 .
AC114494 Genomic DNA. No translation available.
BC084580 mRNA. Translation: AAH84580.1 .
BC126283 mRNA. Translation: AAI26284.1 .
BC126285 mRNA. Translation: AAI26286.1 .
CCDSi CCDS30662.1. [Q96SA4-1 ]
CCDS55583.1. [Q96SA4-4 ]
CCDS55584.1. [Q96SA4-3 ]
CCDS55585.1. [Q96SA4-2 ]
RefSeqi NP_001185966.1. NM_001199037.1. [Q96SA4-3 ]
NP_001185967.1. NM_001199038.1. [Q96SA4-4 ]
NP_001185968.1. NM_001199039.1.
NP_061035.2. NM_018565.3. [Q96SA4-2 ]
NP_849196.2. NM_178865.4. [Q96SA4-1 ]
UniGenei Hs.270655.

3D structure databases

ProteinModelPortali Q96SA4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131485. 8 interactions.

PTM databases

PhosphoSitei Q96SA4.

Polymorphism databases

DMDMi 380865453.

Proteomic databases

PaxDbi Q96SA4.
PRIDEi Q96SA4.

Protocols and materials databases

DNASUi 347735.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373709 ; ENSP00000362813 ; ENSG00000168528 . [Q96SA4-1 ]
ENST00000373710 ; ENSP00000362814 ; ENSG00000168528 . [Q96SA4-4 ]
ENST00000536384 ; ENSP00000439048 ; ENSG00000168528 . [Q96SA4-2 ]
ENST00000536859 ; ENSP00000444307 ; ENSG00000168528 . [Q96SA4-3 ]
GeneIDi 347735.
KEGGi hsa:347735.
UCSCi uc001bst.3. human. [Q96SA4-1 ]
uc010ogg.2. human. [Q96SA4-3 ]
uc010ogh.2. human. [Q96SA4-2 ]

Organism-specific databases

CTDi 347735.
GeneCardsi GC01P031883.
H-InvDB HIX0000354.
HGNCi HGNC:23231. SERINC2.
HPAi HPA005974.
MIMi 614549. gene.
neXtProti NX_Q96SA4.
PharmGKBi PA134933002.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG308011.
GeneTreei ENSGT00550000074522.
HOGENOMi HOG000165463.
HOVERGENi HBG025699.
InParanoidi Q96SA4.
OMAi KCNPHLP.
OrthoDBi EOG7TXKGQ.
TreeFami TF312881.

Miscellaneous databases

ChiTaRSi SERINC2. human.
GenomeRNAii 347735.
NextBioi 99270.
PROi Q96SA4.
SOURCEi Search...

Gene expression databases

Bgeei Q96SA4.
Genevestigatori Q96SA4.

Family and domain databases

InterProi IPR029554. SERINC2.
IPR005016. TDE1/TMS.
[Graphical view ]
PANTHERi PTHR10383. PTHR10383. 1 hit.
PTHR10383:SF22. PTHR10383:SF22. 1 hit.
Pfami PF03348. Serinc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of FKSG84, a novel gene located on human chromosome 1."
    Wang Y.-G., Gong L.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Li N., Zhang W., Wan T., Cao X.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Mammary gland.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.

Entry informationi

Entry nameiSERC2_HUMAN
AccessioniPrimary (citable) accession number: Q96SA4
Secondary accession number(s): A0AVB4
, B4DJK5, B7Z567, B7ZAP2, E7EUZ9, Q86Y23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 21, 2012
Last modified: November 26, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3