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Protein

Myeloid-associated differentiation marker

Gene

MYADM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • establishment of endothelial barrier Source: UniProtKB
  • membrane raft organization Source: UniProtKB
  • negative regulation of actin filament polymerization Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of heterotypic cell-cell adhesion Source: UniProtKB
  • negative regulation of protein kinase C signaling Source: UniProtKB
  • negative regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
  • positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
  • protein targeting to plasma membrane Source: UniProtKB
Complete GO annotation...

Protein family/group databases

TCDBi1.A.64.3.1. the plasmolipin (plasmolipin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid-associated differentiation marker
Alternative name(s):
Protein SB135
Gene namesi
Name:MYADM
ORF Names:UNQ553/PRO1110
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:7544. MYADM.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121HelicalSequence analysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence analysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell-cell junction Source: UniProtKB
  • cortical actin cytoskeleton Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • ruffle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31344.

Polymorphism and mutation databases

BioMutaiMYADM.
DMDMi21263793.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Myeloid-associated differentiation markerPRO_0000156816Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96S97.
MaxQBiQ96S97.
PaxDbiQ96S97.
PeptideAtlasiQ96S97.
PRIDEiQ96S97.

PTM databases

iPTMnetiQ96S97.
PhosphoSiteiQ96S97.
SwissPalmiQ96S97.

Expressioni

Tissue specificityi

Widely expressed. Not detected in thymus.1 Publication

Gene expression databases

BgeeiQ96S97.
CleanExiHS_MYADM.
ExpressionAtlasiQ96S97. baseline and differential.
GenevisibleiQ96S97. HS.

Organism-specific databases

HPAiHPA056301.

Interactioni

Protein-protein interaction databases

BioGridi124862. 25 interactions.
STRINGi9606.ENSP00000337222.

Structurei

3D structure databases

ProteinModelPortaliQ96S97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 163133MARVEL 1PROSITE-ProRule annotationAdd
BLAST
Domaini168 – 319152MARVEL 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAL family.Curated
Contains 2 MARVEL domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00390000010832.
HOVERGENiHBG052545.
InParanoidiQ96S97.
OMAiFPITYAC.
PhylomeDBiQ96S97.
TreeFamiTF331088.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 2 hits.
[Graphical view]
PROSITEiPS51225. MARVEL. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96S97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVTVTRTTI TTTTTSSSGL GSPMIVGSPR ALTQPLGLLR LLQLVSTCVA
60 70 80 90 100
FSLVASVGAW TGSMGNWSMF TWCFCFSVTL IILIVELCGL QARFPLSWRN
110 120 130 140 150
FPITFACYAA LFCLSASIIY PTTYVQFLSH GRSRDHAIAA TFFSCIACVA
160 170 180 190 200
YATEVAWTRA RPGEITGYMA TVPGLLKVLE TFVACIIFAF ISDPNLYQHQ
210 220 230 240 250
PALEWCVAVY AICFILAAIA ILLNLGECTN VLPIPFPSFL SGLALLSVLL
260 270 280 290 300
YATALVLWPL YQFDEKYGGQ PRRSRDVSCS RSHAYYVCAW DRRLAVAILT
310 320
AINLLAYVAD LVHSAHLVFV KV
Length:322
Mass (Da):35,274
Last modified:March 1, 2002 - v2
Checksum:iA92142CC63625A4E
GO

Sequence cautioni

The sequence AAP97182.1 differs from that shown. Reason: Frameshift at positions 228, 277 and 278. Curated
The sequence BAB55302.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 9418Missing in BAC04265 (PubMed:14702039).CuratedAdd
BLAST
Sequence conflicti279 – 2791C → G (PubMed:12075932).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087882 mRNA. Translation: AAP97182.1. Frameshift.
AY037147 mRNA. Translation: AAK67628.2.
AY358582 mRNA. Translation: AAQ88945.1.
AK027693 mRNA. Translation: BAB55302.1. Different initiation.
AK093999 mRNA. Translation: BAC04265.1.
AK075276 mRNA. Translation: BAC11513.1.
AK316566 mRNA. Translation: BAG38155.1.
CH471135 Genomic DNA. Translation: EAW72159.1.
BC013995 mRNA. Translation: AAH13995.1.
BC095412 mRNA. Translation: AAH95412.1.
CCDSiCCDS12866.1.
RefSeqiNP_001018654.1. NM_001020818.2.
NP_001018655.1. NM_001020819.2.
NP_001018656.1. NM_001020820.2.
NP_001018657.1. NM_001020821.2.
NP_001277117.1. NM_001290188.1.
NP_001277118.1. NM_001290189.1.
NP_001277119.1. NM_001290190.1.
NP_001277120.1. NM_001290191.1.
NP_001277121.1. NM_001290192.1.
NP_001277122.1. NM_001290193.1.
NP_001277123.1. NM_001290194.1.
NP_612382.1. NM_138373.4.
UniGeneiHs.380906.

Genome annotation databases

EnsembliENST00000336967; ENSP00000337222; ENSG00000179820.
ENST00000391768; ENSP00000375648; ENSG00000179820.
ENST00000391769; ENSP00000375649; ENSG00000179820.
ENST00000391770; ENSP00000375650; ENSG00000179820.
ENST00000391771; ENSP00000375651; ENSG00000179820.
GeneIDi91663.
KEGGihsa:91663.
UCSCiuc002qcl.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087882 mRNA. Translation: AAP97182.1. Frameshift.
AY037147 mRNA. Translation: AAK67628.2.
AY358582 mRNA. Translation: AAQ88945.1.
AK027693 mRNA. Translation: BAB55302.1. Different initiation.
AK093999 mRNA. Translation: BAC04265.1.
AK075276 mRNA. Translation: BAC11513.1.
AK316566 mRNA. Translation: BAG38155.1.
CH471135 Genomic DNA. Translation: EAW72159.1.
BC013995 mRNA. Translation: AAH13995.1.
BC095412 mRNA. Translation: AAH95412.1.
CCDSiCCDS12866.1.
RefSeqiNP_001018654.1. NM_001020818.2.
NP_001018655.1. NM_001020819.2.
NP_001018656.1. NM_001020820.2.
NP_001018657.1. NM_001020821.2.
NP_001277117.1. NM_001290188.1.
NP_001277118.1. NM_001290189.1.
NP_001277119.1. NM_001290190.1.
NP_001277120.1. NM_001290191.1.
NP_001277121.1. NM_001290192.1.
NP_001277122.1. NM_001290193.1.
NP_001277123.1. NM_001290194.1.
NP_612382.1. NM_138373.4.
UniGeneiHs.380906.

3D structure databases

ProteinModelPortaliQ96S97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124862. 25 interactions.
STRINGi9606.ENSP00000337222.

Protein family/group databases

TCDBi1.A.64.3.1. the plasmolipin (plasmolipin) family.

PTM databases

iPTMnetiQ96S97.
PhosphoSiteiQ96S97.
SwissPalmiQ96S97.

Polymorphism and mutation databases

BioMutaiMYADM.
DMDMi21263793.

Proteomic databases

EPDiQ96S97.
MaxQBiQ96S97.
PaxDbiQ96S97.
PeptideAtlasiQ96S97.
PRIDEiQ96S97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336967; ENSP00000337222; ENSG00000179820.
ENST00000391768; ENSP00000375648; ENSG00000179820.
ENST00000391769; ENSP00000375649; ENSG00000179820.
ENST00000391770; ENSP00000375650; ENSG00000179820.
ENST00000391771; ENSP00000375651; ENSG00000179820.
GeneIDi91663.
KEGGihsa:91663.
UCSCiuc002qcl.4. human.

Organism-specific databases

CTDi91663.
GeneCardsiMYADM.
HGNCiHGNC:7544. MYADM.
HPAiHPA056301.
MIMi609959. gene.
neXtProtiNX_Q96S97.
PharmGKBiPA31344.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00390000010832.
HOVERGENiHBG052545.
InParanoidiQ96S97.
OMAiFPITYAC.
PhylomeDBiQ96S97.
TreeFamiTF331088.

Miscellaneous databases

ChiTaRSiMYADM. human.
GeneWikiiMYADM.
GenomeRNAii91663.
PROiQ96S97.
SOURCEiSearch...

Gene expression databases

BgeeiQ96S97.
CleanExiHS_MYADM.
ExpressionAtlasiQ96S97. baseline and differential.
GenevisibleiQ96S97. HS.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 2 hits.
[Graphical view]
PROSITEiPS51225. MARVEL. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid."
    Cui W., Yu L., He H., Chu Y., Gao J., Wan B., Tang L., Zhao S.
    Mol. Biol. Rep. 28:123-138(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Bone marrow.
  2. Li N., Wan T., Zhang W., Cao X.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma and Uterus.
  5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thyroid.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Placenta.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMYADM_HUMAN
AccessioniPrimary (citable) accession number: Q96S97
Secondary accession number(s): B2RE58
, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96SK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.