Reviewed, UniProtKB/Swiss-Prot Q96S96 (PEBP4_HUMAN)

Names and origin

Protein names

Recommended name:
    Phosphatidylethanolamine-binding protein 4
      Short name=PEBP-4
      Short name=hPEBP4
Alternative name(s):
    Protein cousin-of-RKIP 1

Gene names

Name:	PEBP4
Synonyms:	CORK1
ORF Names:	UNQ1933/PRO4408

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization.
Subcellular location	Lysosome.
Tissue specificity	Ubiquitously expressed. Highly expressed in tumor cells.
Sequence similarities	Belongs to the phosphatidylethanolamine-binding protein family.
Sequence caution	The sequence AAH20779.1 differs from that shown. Reason: Frameshift at position 219. The sequence AAQ89467.1 differs from that shown. Reason: Frameshift at position 219.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22
	Chain	23 – 227	205	Phosphatidylethanolamine-binding protein 4		PRO_0000023279
Experimental info
	Sequence conflict	125	1	K → E in AAW56965. Ref.2
	Sequence conflict	125	1	K → E in AAH20779. Ref.4
	Sequence conflict	211	1	E → G in AAQ89467. Ref.3
	Sequence conflict	211	1	E → G in AAH20779. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q96S96-1 [UniParc]. Last modified April 3, 2007. Version 3. Checksum: 0F6BD35F5EE63EC4	FASTA	227	25,733
	10 20 30 40 50 60 MGWTMRLVTA ALLLGLMMVV TGDEDENSPC AHEALLDEDT LFCQGLEVFY PELGNIGCKV 70 80 90 100 110 120 VPDCNNYRQK ITSWMEPIVK FPGAVDGATY ILVMVDPDAP SRAEPRQRFW RHWLVTDIKG 130 140 150 160 170 180 ADLKKGKIQG QELSAYQAPS PPAHSGFHRY QFFVYLQEGK VISLLPKENK TRGSWKMDRF 190 200 210 220 LNRFHLGEPE ASTQFMTQNY QDSPTLQAPR ERASEPKHKN QAEIAAC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization." Wang X., Li N., Liu B., Sun H., Chen T., Li H., Qiu J., Zhang L., Wan T., Cao X. J. Biol. Chem. 279:45855-45864(2004) [PubMed: 15302887] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Cousin-of-RKIP 1 promotes myoblast differentiation." Garcia R.L., Fee F., Kolch W. Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-37.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY037148 mRNA. Translation: AAK67629.1. AY730275 mRNA. Translation: AAW56965.1. AY359109 mRNA. Translation: AAQ89467.1. Frameshift. BC020779 mRNA. Translation: AAH20779.1. Frameshift.
RefSeq	NP_659399.2.
UniGene	Hs.491242
3D structure databases
HSSP	HSSP built from PDB template 1A44 based on UniProtKB P13696.
ModBase	Search...
Proteomic databases
PeptideAtlas	Q96S96.
Genome annotation databases
Ensembl	ENSG00000134020. Homo sapiens. [Contig view]
GeneID	157310.
KEGG	hsa:157310.
NMPDR	fig|9606.3.peg.30057.
Organism-specific databases
H-InvDB	HIX0007380.
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q96S96.
HOVERGEN	Q96S96.
Gene expression databases
ArrayExpress	Q96S96.
GermOnline	ENSG00000134020. Homo sapiens.
Family and domain databases
InterPro	IPR001858. Phosphotidylethanolamine_bd_CS. IPR008914. PtdEtn-bd_prot_PEBP. [Graphical view]
Gene3D	G3DSA:3.90.280.10. PEBP. 1 hit.
Pfam	PF01161. PBP. 1 hit. [Graphical view]
ProDom	PD004330. PBP. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01220. PBP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	87448.

Entry information

Entry name

PEBP4_HUMAN

Accession

Primary (citable) accession number: Q96S96
Secondary accession number(s): Q5EVA1, Q8WW74

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	April 3, 2007
Last modified:	November 4, 2008
This is version 50 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)