Q96S96 (PEBP4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylethanolamine-binding protein 4
Short name=PEBP-4
Short name=hPEBP4

Alternative name(s):
Protein cousin-of-RKIP 1

Gene names

Name:	PEBP4
Synonyms:	CORK1
ORF Names:	UNQ1933/PRO4408

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization. Ref.1
Subcellular location	Lysosome Ref.1.
Tissue specificity	Ubiquitously expressed. Highly expressed in tumor cells. Ref.1
Sequence similarities	Belongs to the phosphatidylethanolamine-binding protein family.
Sequence caution	The sequence AAH20779.1 differs from that shown. Reason: Frameshift at position 219. The sequence AAQ89467.1 differs from that shown. Reason: Frameshift at position 219.

Ontologies

Keywords
Cellular component	Lysosome
Coding sequence diversity	Polymorphism
Domain	Signal
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Ref.5
	Chain	23 – 227	205	Phosphatidylethanolamine-binding protein 4		PRO_0000023279
Natural variations
	Natural variant	125	1	K → E. Ref.2 Ref.4 Corresponds to variant rs1129474 [ dbSNP | Ensembl ].		VAR_050467
	Natural variant	211	1	E → G. Ref.3 Ref.4 Corresponds to variant rs1047406 [ dbSNP | Ensembl ].		VAR_050468

Sequences

	Sequence		Length	Mass (Da)
	Q96S96 [UniParc]. Last modified April 3, 2007. Version 3. Checksum: 0F6BD35F5EE63EC4	FASTA	227	25,733
	10 20 30 40 50 60 MGWTMRLVTA ALLLGLMMVV TGDEDENSPC AHEALLDEDT LFCQGLEVFY PELGNIGCKV 70 80 90 100 110 120 VPDCNNYRQK ITSWMEPIVK FPGAVDGATY ILVMVDPDAP SRAEPRQRFW RHWLVTDIKG 130 140 150 160 170 180 ADLKKGKIQG QELSAYQAPS PPAHSGFHRY QFFVYLQEGK VISLLPKENK TRGSWKMDRF 190 200 210 220 LNRFHLGEPE ASTQFMTQNY QDSPTLQAPR ERASEPKHKN QAEIAAC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization." Wang X., Li N., Liu B., Sun H., Chen T., Li H., Qiu J., Zhang L., Wan T., Cao X. J. Biol. Chem. 279:45855-45864(2004) [PubMed: 15302887] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Cousin-of-RKIP 1 promotes myoblast differentiation." Garcia R.L., Fee F., Kolch W. Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-125.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-211.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-125 AND GLY-211. Tissue: Lung.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-37.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY037148 mRNA. Translation: AAK67629.1. AY730275 mRNA. Translation: AAW56965.1. AY359109 mRNA. Translation: AAQ89467.1. Frameshift. BC020779 mRNA. Translation: AAH20779.1. Frameshift.
IPI	IPI00163563.
RefSeq	NP_659399.2. NM_144962.2.
UniGene	Hs.491242.
3D structure databases
ProteinModelPortal	Q96S96.
SMR	Q96S96. Positions 45-199.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-7014133.
STRING	Q96S96.
Polymorphism databases
DMDM	143811436.
Proteomic databases
PeptideAtlas	Q96S96.
PRIDE	Q96S96.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000256404; ENSP00000256404; ENSG00000134020.
GeneID	157310.
KEGG	hsa:157310.
NMPDR	fig|9606.3.peg.30057.
UCSC	uc003xcn.1. human.
Organism-specific databases
CTD	157310.
GeneCards	GC08M022570.
H-InvDB	HIX0007380.
HGNC	HGNC:28319. PEBP4.
HPA	HPA025064.
MIM	612473. gene.
neXtProt	NX_Q96S96.
PharmGKB	PA165585814.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05827.
GeneTree	ENSGT00510000048825.
HOGENOM	HBG125368.
HOVERGEN	HBG053558.
InParanoid	Q96S96.
OMA	FMTQNYQ.
OrthoDB	EOG4BVRVG.
PhylomeDB	Q96S96.
Gene expression databases
ArrayExpress	Q96S96.
Bgee	Q96S96.
Genevestigator	Q96S96.
GermOnline	ENSG00000134020. Homo sapiens.
Family and domain databases
InterPro	IPR001858. Phosphotidylethanolamine-bd_CS. IPR008914. PtdEtn-bd_prot_PEBP. [Graphical view]
Gene3D	G3DSA:3.90.280.10. PEBP. 1 hit.
Pfam	PF01161. PBP. 1 hit. [Graphical view]
SUPFAM	SSF49777. PEBP. 1 hit.
PROSITE	PS01220. PBP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	87448.
SOURCE	Search...

Entry information

Entry name

PEBP4_HUMAN

Accession

Primary (citable) accession number: Q96S96
Secondary accession number(s): Q5EVA1, Q8WW74

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	April 3, 2007
Last modified:	January 25, 2012
This is version 78 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.