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Protein

Phosphatidylethanolamine-binding protein 4

Gene

PEBP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization.1 Publication

Enzyme and pathway databases

SignaLinkiQ96S96.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylethanolamine-binding protein 4
Short name:
PEBP-4
Short name:
hPEBP4
Alternative name(s):
Protein cousin-of-RKIP 1
Gene namesi
Name:PEBP4
Synonyms:CORK1
ORF Names:UNQ1933/PRO4408
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:28319. PEBP4.

Subcellular locationi

  • Lysosome 1 Publication

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165585814.

Polymorphism and mutation databases

BioMutaiPEBP4.
DMDMi143811436.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 227205Phosphatidylethanolamine-binding protein 4PRO_0000023279Add
BLAST

Proteomic databases

PaxDbiQ96S96.
PeptideAtlasiQ96S96.
PRIDEiQ96S96.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in tumor cells.1 Publication

Gene expression databases

BgeeiQ96S96.
ExpressionAtlasiQ96S96. baseline and differential.
GenevisibleiQ96S96. HS.

Organism-specific databases

HPAiHPA025064.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AKT1P317492EBI-8563667,EBI-296087
RAF1P040494EBI-8563667,EBI-365996

Protein-protein interaction databases

BioGridi127592. 2 interactions.
IntActiQ96S96. 3 interactions.
MINTiMINT-7014133.
STRINGi9606.ENSP00000256404.

Structurei

3D structure databases

ProteinModelPortaliQ96S96.
SMRiQ96S96. Positions 52-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3346. Eukaryota.
COG1881. LUCA.
GeneTreeiENSGT00840000129869.
HOGENOMiHOG000115488.
HOVERGENiHBG053558.
InParanoidiQ96S96.
OMAiFMTQNYQ.
OrthoDBiEOG70PC0C.
PhylomeDBiQ96S96.
TreeFamiTF315074.

Family and domain databases

Gene3Di3.90.280.10. 1 hit.
InterProiIPR008914. PEBP.
IPR001858. Phosphotidylethanolamine-bd_CS.
[Graphical view]
PfamiPF01161. PBP. 1 hit.
[Graphical view]
SUPFAMiSSF49777. SSF49777. 1 hit.
PROSITEiPS01220. PBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96S96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWTMRLVTA ALLLGLMMVV TGDEDENSPC AHEALLDEDT LFCQGLEVFY
60 70 80 90 100
PELGNIGCKV VPDCNNYRQK ITSWMEPIVK FPGAVDGATY ILVMVDPDAP
110 120 130 140 150
SRAEPRQRFW RHWLVTDIKG ADLKKGKIQG QELSAYQAPS PPAHSGFHRY
160 170 180 190 200
QFFVYLQEGK VISLLPKENK TRGSWKMDRF LNRFHLGEPE ASTQFMTQNY
210 220
QDSPTLQAPR ERASEPKHKN QAEIAAC
Length:227
Mass (Da):25,733
Last modified:April 3, 2007 - v3
Checksum:i0F6BD35F5EE63EC4
GO

Sequence cautioni

The sequence AAH20779.1 differs from that shown. Reason: Frameshift at position 219. Curated
The sequence AAQ89467.1 differs from that shown. Reason: Frameshift at position 219. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti125 – 1251K → E.2 Publications
Corresponds to variant rs1129474 [ dbSNP | Ensembl ].
VAR_050467
Natural varianti211 – 2111E → G.2 Publications
Corresponds to variant rs1047406 [ dbSNP | Ensembl ].
VAR_050468

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037148 mRNA. Translation: AAK67629.1.
AY730275 mRNA. Translation: AAW56965.1.
AY359109 mRNA. Translation: AAQ89467.1. Frameshift.
BC020779 mRNA. Translation: AAH20779.1. Frameshift.
CCDSiCCDS43724.1.
RefSeqiNP_659399.2. NM_144962.2.
XP_011542715.1. XM_011544413.1.
XP_011542716.1. XM_011544414.1.
UniGeneiHs.491242.

Genome annotation databases

EnsembliENST00000256404; ENSP00000256404; ENSG00000134020.
GeneIDi157310.
KEGGihsa:157310.
UCSCiuc003xcn.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037148 mRNA. Translation: AAK67629.1.
AY730275 mRNA. Translation: AAW56965.1.
AY359109 mRNA. Translation: AAQ89467.1. Frameshift.
BC020779 mRNA. Translation: AAH20779.1. Frameshift.
CCDSiCCDS43724.1.
RefSeqiNP_659399.2. NM_144962.2.
XP_011542715.1. XM_011544413.1.
XP_011542716.1. XM_011544414.1.
UniGeneiHs.491242.

3D structure databases

ProteinModelPortaliQ96S96.
SMRiQ96S96. Positions 52-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127592. 2 interactions.
IntActiQ96S96. 3 interactions.
MINTiMINT-7014133.
STRINGi9606.ENSP00000256404.

Polymorphism and mutation databases

BioMutaiPEBP4.
DMDMi143811436.

Proteomic databases

PaxDbiQ96S96.
PeptideAtlasiQ96S96.
PRIDEiQ96S96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256404; ENSP00000256404; ENSG00000134020.
GeneIDi157310.
KEGGihsa:157310.
UCSCiuc003xcn.2. human.

Organism-specific databases

CTDi157310.
GeneCardsiPEBP4.
H-InvDBHIX0007380.
HGNCiHGNC:28319. PEBP4.
HPAiHPA025064.
MIMi612473. gene.
neXtProtiNX_Q96S96.
PharmGKBiPA165585814.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3346. Eukaryota.
COG1881. LUCA.
GeneTreeiENSGT00840000129869.
HOGENOMiHOG000115488.
HOVERGENiHBG053558.
InParanoidiQ96S96.
OMAiFMTQNYQ.
OrthoDBiEOG70PC0C.
PhylomeDBiQ96S96.
TreeFamiTF315074.

Enzyme and pathway databases

SignaLinkiQ96S96.

Miscellaneous databases

ChiTaRSiPEBP4. human.
GenomeRNAii157310.
PROiQ96S96.
SOURCEiSearch...

Gene expression databases

BgeeiQ96S96.
ExpressionAtlasiQ96S96. baseline and differential.
GenevisibleiQ96S96. HS.

Family and domain databases

Gene3Di3.90.280.10. 1 hit.
InterProiIPR008914. PEBP.
IPR001858. Phosphotidylethanolamine-bd_CS.
[Graphical view]
PfamiPF01161. PBP. 1 hit.
[Graphical view]
SUPFAMiSSF49777. SSF49777. 1 hit.
PROSITEiPS01220. PBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization."
    Wang X., Li N., Liu B., Sun H., Chen T., Li H., Qiu J., Zhang L., Wan T., Cao X.
    J. Biol. Chem. 279:45855-45864(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Cousin-of-RKIP 1 promotes myoblast differentiation."
    Garcia R.L., Fee F., Kolch W.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-125.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-211.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-125 AND GLY-211.
    Tissue: Lung.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-37.

Entry informationi

Entry nameiPEBP4_HUMAN
AccessioniPrimary (citable) accession number: Q96S96
Secondary accession number(s): Q5EVA1, Q8WW74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 3, 2007
Last modified: June 8, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.