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Protein

Calcium/calmodulin-dependent protein kinase II inhibitor 2

Gene

CAMK2N2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca2+/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca2+/calmodulin on CAMK2.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionProtein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase II inhibitor 2
Alternative name(s):
CaM-KII inhibitory protein
Short name:
CaM-KIIN
Gene namesi
Name:CAMK2N2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163888.3.
HGNCiHGNC:24197. CAMK2N2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163888.
PharmGKBiPA142672210.

Polymorphism and mutation databases

BioMutaiCAMK2N2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003272661 – 79Calcium/calmodulin-dependent protein kinase II inhibitor 2Add BLAST79

Proteomic databases

EPDiQ96S95.
PaxDbiQ96S95.
PeptideAtlasiQ96S95.
PRIDEiQ96S95.

PTM databases

iPTMnetiQ96S95.
PhosphoSitePlusiQ96S95.

Expressioni

Tissue specificityi

Expressed in cell lines including hemopoietic cell lines and some tumor cell lines. Highly Expressed in stimulated dendritic cell (DC) and weakly expressed in unstimulated mature and immature DC. Highly expressed in kidney, liver, in cell lines HeLaS3, lymphoblastic leukemia MOLT-4, and Burkitt's lymphoma Raji. Moderately expressed in heart, skeletal muscle, placenta, and chronic myelogenous leukemia K-562 cells. Weakly expressed in small intestine, colorectal adenocarcinoma SW480, and lung carcinoma A-549 cells.1 Publication

Gene expression databases

BgeeiENSG00000163888.
CleanExiHS_CAMK2N2.
GenevisibleiQ96S95. HS.

Organism-specific databases

HPAiHPA050835.

Interactioni

Subunit structurei

Interacts with CAMK2A and CAMK2B in the presence of Ca2+/calmodulin or after autophosphorylation.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125100. 1 interactor.
STRINGi9606.ENSP00000296238.

Structurei

3D structure databases

ProteinModelPortaliQ96S95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 69Inhibitory domainBy similarityAdd BLAST27

Domaini

The inhibitory domain blocks CAMK2 binding to GRIN2B.By similarity

Sequence similaritiesi

Belongs to the CAMK2N family.Curated

Phylogenomic databases

eggNOGiENOG410J0NK. Eukaryota.
ENOG411202V. LUCA.
GeneTreeiENSGT00390000004940.
HOGENOMiHOG000060311.
HOVERGENiHBG104926.
InParanoidiQ96S95.
OMAiLQDTNTF.
OrthoDBiEOG091G15S0.
PhylomeDBiQ96S95.
TreeFamiTF333175.

Family and domain databases

InterProiView protein in InterPro
IPR026779. Camk2n.
PANTHERiPTHR31007. PTHR31007. 1 hit.
PfamiView protein in Pfam
PF15170. CaM-KIIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96S95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEILPYSED KMGRFGADPE GSDLSFSCRL QDTNSFFAGN QAKRPPKLGQ
60 70
IGRAKRVVIE DDRIDDVLKG MGEKPPSGV
Length:79
Mass (Da):8,658
Last modified:December 1, 2001 - v1
Checksum:i160C31A092417CEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037149 mRNA. Translation: AAK67630.1.
CH471052 Genomic DNA. Translation: EAW78280.1.
BC105077 mRNA. Translation: AAI05078.1.
BC105079 mRNA. Translation: AAI05080.1.
CCDSiCCDS3257.1.
RefSeqiNP_150284.1. NM_033259.2.
UniGeneiHs.585003.

Genome annotation databases

EnsembliENST00000296238; ENSP00000296238; ENSG00000163888.
GeneIDi94032.
KEGGihsa:94032.
UCSCiuc003fnj.2. human.

Similar proteinsi

Entry informationi

Entry nameiCK2N2_HUMAN
AccessioniPrimary (citable) accession number: Q96S95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families