Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcium/calmodulin-dependent protein kinase II inhibitor 2

Gene

CAMK2N2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca2+/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca2+/calmodulin on CAMK2.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase II inhibitor 2
Alternative name(s):
CaM-KII inhibitory protein
Short name:
CaM-KIIN
Gene namesi
Name:CAMK2N2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24197. CAMK2N2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672210.

Polymorphism and mutation databases

BioMutaiCAMK2N2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7979Calcium/calmodulin-dependent protein kinase II inhibitor 2PRO_0000327266Add
BLAST

Proteomic databases

EPDiQ96S95.
PaxDbiQ96S95.
PeptideAtlasiQ96S95.
PRIDEiQ96S95.

PTM databases

iPTMnetiQ96S95.
PhosphoSiteiQ96S95.

Expressioni

Tissue specificityi

Expressed in cell lines including hemopoietic cell lines and some tumor cell lines. Highly Expressed in stimulated dendritic cell (DC) and weakly expressed in unstimulated mature and immature DC. Highly expressed in kidney, liver, in cell lines HeLaS3, lymphoblastic leukemia MOLT-4, and Burkitt's lymphoma Raji. Moderately expressed in heart, skeletal muscle, placenta, and chronic myelogenous leukemia K-562 cells. Weakly expressed in small intestine, colorectal adenocarcinoma SW480, and lung carcinoma A-549 cells.1 Publication

Gene expression databases

BgeeiQ96S95.
CleanExiHS_CAMK2N2.
GenevisibleiQ96S95. HS.

Interactioni

Subunit structurei

Interacts with CAMK2A and CAMK2B in the presence of Ca2+/calmodulin or after autophosphorylation.By similarity

Protein-protein interaction databases

BioGridi125100. 1 interaction.
STRINGi9606.ENSP00000296238.

Structurei

3D structure databases

ProteinModelPortaliQ96S95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 6927Inhibitory domainBy similarityAdd
BLAST

Domaini

The inhibitory domain blocks CAMK2 binding to GRIN2B.By similarity

Sequence similaritiesi

Belongs to the CAMK2N family.Curated

Phylogenomic databases

eggNOGiENOG410J0NK. Eukaryota.
ENOG411202V. LUCA.
GeneTreeiENSGT00390000004940.
HOGENOMiHOG000060311.
HOVERGENiHBG104926.
InParanoidiQ96S95.
OMAiLQDTNTF.
OrthoDBiEOG7TF7CN.
PhylomeDBiQ96S95.
TreeFamiTF333175.

Family and domain databases

InterProiIPR026779. Camk2n.
[Graphical view]
PANTHERiPTHR31007. PTHR31007. 1 hit.
PfamiPF15170. CaM-KIIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96S95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEILPYSED KMGRFGADPE GSDLSFSCRL QDTNSFFAGN QAKRPPKLGQ
60 70
IGRAKRVVIE DDRIDDVLKG MGEKPPSGV
Length:79
Mass (Da):8,658
Last modified:December 1, 2001 - v1
Checksum:i160C31A092417CEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037149 mRNA. Translation: AAK67630.1.
CH471052 Genomic DNA. Translation: EAW78280.1.
BC105077 mRNA. Translation: AAI05078.1.
BC105079 mRNA. Translation: AAI05080.1.
CCDSiCCDS3257.1.
RefSeqiNP_150284.1. NM_033259.2.
UniGeneiHs.585003.

Genome annotation databases

EnsembliENST00000296238; ENSP00000296238; ENSG00000163888.
GeneIDi94032.
KEGGihsa:94032.
UCSCiuc003fnj.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037149 mRNA. Translation: AAK67630.1.
CH471052 Genomic DNA. Translation: EAW78280.1.
BC105077 mRNA. Translation: AAI05078.1.
BC105079 mRNA. Translation: AAI05080.1.
CCDSiCCDS3257.1.
RefSeqiNP_150284.1. NM_033259.2.
UniGeneiHs.585003.

3D structure databases

ProteinModelPortaliQ96S95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125100. 1 interaction.
STRINGi9606.ENSP00000296238.

PTM databases

iPTMnetiQ96S95.
PhosphoSiteiQ96S95.

Polymorphism and mutation databases

BioMutaiCAMK2N2.

Proteomic databases

EPDiQ96S95.
PaxDbiQ96S95.
PeptideAtlasiQ96S95.
PRIDEiQ96S95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296238; ENSP00000296238; ENSG00000163888.
GeneIDi94032.
KEGGihsa:94032.
UCSCiuc003fnj.2. human.

Organism-specific databases

CTDi94032.
GeneCardsiCAMK2N2.
HGNCiHGNC:24197. CAMK2N2.
MIMi608721. gene.
neXtProtiNX_Q96S95.
PharmGKBiPA142672210.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0NK. Eukaryota.
ENOG411202V. LUCA.
GeneTreeiENSGT00390000004940.
HOGENOMiHOG000060311.
HOVERGENiHBG104926.
InParanoidiQ96S95.
OMAiLQDTNTF.
OrthoDBiEOG7TF7CN.
PhylomeDBiQ96S95.
TreeFamiTF333175.

Miscellaneous databases

GenomeRNAii94032.
PROiQ96S95.
SOURCEiSearch...

Gene expression databases

BgeeiQ96S95.
CleanExiHS_CAMK2N2.
GenevisibleiQ96S95. HS.

Family and domain databases

InterProiIPR026779. Camk2n.
[Graphical view]
PANTHERiPTHR31007. PTHR31007. 1 hit.
PfamiPF15170. CaM-KIIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel calcium/calmodulin-dependent protein kinase II inhibitor from human dendritic cells."
    Zhang J., Li N., Yu J., Zhang W., Cao X.
    Biochem. Biophys. Res. Commun. 285:229-234(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Dendritic cell.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCK2N2_HUMAN
AccessioniPrimary (citable) accession number: Q96S95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.