Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin-L2

Gene

CCNL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:G66-32396-MONOMER.
SignaLinkiQ96S94.
SIGNORiQ96S94.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-L2
Alternative name(s):
Paneth cell-enhanced expression protein
Gene namesi
Name:CCNL2
ORF Names:SB138
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20570. CCNL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi81669.
OpenTargetsiENSG00000221978.
PharmGKBiPA134973681.

Polymorphism and mutation databases

BioMutaiCCNL2.
DMDMi74752124.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000804872 – 520Cyclin-L2Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei369PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96S94.
MaxQBiQ96S94.
PaxDbiQ96S94.
PeptideAtlasiQ96S94.
PRIDEiQ96S94.
TopDownProteomicsiQ96S94-1. [Q96S94-1]

PTM databases

iPTMnetiQ96S94.
PhosphoSitePlusiQ96S94.

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiENSG00000221978.
CleanExiHS_CCNL2.
ExpressionAtlasiQ96S94. baseline and differential.
GenevisibleiQ96S94. HS.

Organism-specific databases

HPAiHPA053137.

Interactioni

Subunit structurei

Interacts with CDK11A, CDK11B, CDK12, CDK13 and POLR2A, the hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II (PubMed:14684736, PubMed:18216018). May form a ternary complex with CDK11B and casein kinase II (CKII) (PubMed:18216018). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7 (PubMed:14684736, PubMed:18216018).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RUNDC3AQ59EK93EBI-1045974,EBI-747225

Protein-protein interaction databases

BioGridi123566. 49 interactors.
IntActiQ96S94. 23 interactors.
STRINGi9606.ENSP00000383611.

Structurei

3D structure databases

ProteinModelPortaliQ96S94.
SMRiQ96S94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 185Cyclin-like 1Add BLAST103
Regioni198 – 282Cyclin-like 2Add BLAST85
Regioni385 – 423RSAdd BLAST39

Domaini

Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).By similarity

Sequence similaritiesi

Belongs to the cyclin family. Cyclin L subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0835. Eukaryota.
COG5333. LUCA.
GeneTreeiENSGT00760000119191.
HOVERGENiHBG056044.
InParanoidiQ96S94.
OMAiTGHRYER.
OrthoDBiEOG091G0BW9.
PhylomeDBiQ96S94.
TreeFamiTF101011.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015429. Cyclin_L/T.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF036580. Cyclin_L. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96S94-1) [UniParc]FASTAAdd to basket
Also known as: cyclin L2alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAAAAGA AGSAAPAAAA GAPGSGGAPS GSQGVLIGDR LYSGVLITLE
60 70 80 90 100
NCLLPDDKLR FTPSMSSGLD TDTETDLRVV GCELIQAAGI LLRLPQVAMA
110 120 130 140 150
TGQVLFQRFF YTKSFVKHSM EHVSMACVHL ASKIEEAPRR IRDVINVFHR
160 170 180 190 200
LRQLRDKKKP VPLLLDQDYV NLKNQIIKAE RRVLKELGFC VHVKHPHKII
210 220 230 240 250
VMYLQVLECE RNQHLVQTSW NYMNDSLRTD VFVRFQPESI ACACIYLAAR
260 270 280 290 300
TLEIPLPNRP HWFLLFGATE EEIQEICLKI LQLYARKKVD LTHLEGEVEK
310 320 330 340 350
RKHAIEEAKA QARGLLPGGT QVLDGTSGFS PAPKLVESPK EGKGSKPSPL
360 370 380 390 400
SVKNTKRRLE GAKKAKADSP VNGLPKGRES RSRSRSREQS YSRSPSRSAS
410 420 430 440 450
PKRRKSDSGS TSGGSKSQSR SRSRSDSPPR QAPRSAPYKG SEIRGSRKSK
460 470 480 490 500
DCKYPQKPHK SRSRSSSRSR SRSRERADNP GKYKKKSHYY RDQRRERSRS
510 520
YERTGRRYER DHPGHSRHRR
Length:520
Mass (Da):58,147
Last modified:December 1, 2001 - v1
Checksum:i4341E55D03D7B0E0
GO
Isoform 2 (identifier: Q96S94-2) [UniParc]FASTAAdd to basket
Also known as: CCNL2s

The sequence of this isoform differs from the canonical sequence as follows:
     221-227: NYMNDSL → VASEGIT
     228-520: Missing.

Show »
Length:227
Mass (Da):24,707
Checksum:iD36EC47ABC9FB2FE
GO
Isoform 3 (identifier: Q96S94-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.

Show »
Length:298
Mass (Da):33,839
Checksum:i96FA9D04F9CCB9F7
GO
Isoform 4 (identifier: Q96S94-4) [UniParc]FASTAAdd to basket
Also known as: cyclin L2betaB

The sequence of this isoform differs from the canonical sequence as follows:
     221-236: NYMNDSLRTDVFVRFQ → VASEDPLLKWDSWQRL
     237-520: Missing.

Show »
Length:236
Mass (Da):25,974
Checksum:iD67DF36F25A43915
GO
Isoform 5 (identifier: Q96S94-5) [UniParc]FASTAAdd to basket
Also known as: cyclin L2betaA

The sequence of this isoform differs from the canonical sequence as follows:
     221-226: NYMNDS → VASEGK
     227-520: Missing.

Show »
Length:226
Mass (Da):24,621
Checksum:i2DA47ABC9FB2FED8
GO

Sequence cautioni

The sequence AAH71622 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB84938 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71T → S in AAH16333 (PubMed:15489334).Curated1
Sequence conflicti324 – 325DG → MS in AAP97201 (Ref. 8) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0161321 – 222Missing in isoform 3. 2 PublicationsAdd BLAST222
Alternative sequenceiVSP_058301221 – 236NYMND…FVRFQ → VASEDPLLKWDSWQRL in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_058302221 – 227NYMNDSL → VASEGIT in isoform 2. 7
Alternative sequenceiVSP_016130221 – 226NYMNDS → VASEGK in isoform 5. 4 Publications6
Alternative sequenceiVSP_016131227 – 520Missing in isoform 5. 4 PublicationsAdd BLAST294
Alternative sequenceiVSP_058303228 – 520Missing in isoform 2. Add BLAST293
Alternative sequenceiVSP_058304237 – 520Missing in isoform 4. Add BLAST284

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037150 mRNA. Translation: AAK67631.1.
AY116620 mRNA. Translation: AAM76789.1.
AK074112 mRNA. Translation: BAB84938.1. Different initiation.
AK056120 mRNA. No translation available.
AK027770 mRNA. Translation: BAG51376.1.
AK292268 mRNA. Translation: BAF84957.1.
AL391244 Genomic DNA. No translation available.
CR628411 Genomic DNA. No translation available.
CH471183 Genomic DNA. Translation: EAW56213.1.
CH471183 Genomic DNA. Translation: EAW56215.1.
CH471183 Genomic DNA. Translation: EAW56216.1.
CH471183 Genomic DNA. Translation: EAW56217.1.
BC016333 mRNA. Translation: AAH16333.1.
BC071622 mRNA. Translation: AAH71622.2. Different initiation.
AL834432 mRNA. Translation: CAD39092.1.
AL834441 mRNA. Translation: CAD39101.1.
AF087903 mRNA. Translation: AAP97201.1.
CCDSiCCDS30557.1. [Q96S94-1]
CCDS30558.1. [Q96S94-5]
RefSeqiNP_001034666.1. NM_001039577.3. [Q96S94-5]
NP_001307082.1. NM_001320153.1. [Q96S94-3]
NP_001307084.1. NM_001320155.1. [Q96S94-3]
NP_112199.2. NM_030937.4. [Q96S94-1]
XP_011540523.1. XM_011542221.2. [Q96S94-3]
XP_016857911.1. XM_017002422.1. [Q96S94-3]
UniGeneiHs.515704.

Genome annotation databases

EnsembliENST00000400809; ENSP00000383611; ENSG00000221978. [Q96S94-1]
ENST00000408918; ENSP00000386158; ENSG00000221978. [Q96S94-5]
ENST00000481223; ENSP00000423734; ENSG00000221978. [Q96S94-4]
ENST00000488340; ENSP00000424647; ENSG00000221978. [Q96S94-2]
GeneIDi81669.
KEGGihsa:81669.
UCSCiuc001afi.3. human. [Q96S94-1]
uc057beg.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037150 mRNA. Translation: AAK67631.1.
AY116620 mRNA. Translation: AAM76789.1.
AK074112 mRNA. Translation: BAB84938.1. Different initiation.
AK056120 mRNA. No translation available.
AK027770 mRNA. Translation: BAG51376.1.
AK292268 mRNA. Translation: BAF84957.1.
AL391244 Genomic DNA. No translation available.
CR628411 Genomic DNA. No translation available.
CH471183 Genomic DNA. Translation: EAW56213.1.
CH471183 Genomic DNA. Translation: EAW56215.1.
CH471183 Genomic DNA. Translation: EAW56216.1.
CH471183 Genomic DNA. Translation: EAW56217.1.
BC016333 mRNA. Translation: AAH16333.1.
BC071622 mRNA. Translation: AAH71622.2. Different initiation.
AL834432 mRNA. Translation: CAD39092.1.
AL834441 mRNA. Translation: CAD39101.1.
AF087903 mRNA. Translation: AAP97201.1.
CCDSiCCDS30557.1. [Q96S94-1]
CCDS30558.1. [Q96S94-5]
RefSeqiNP_001034666.1. NM_001039577.3. [Q96S94-5]
NP_001307082.1. NM_001320153.1. [Q96S94-3]
NP_001307084.1. NM_001320155.1. [Q96S94-3]
NP_112199.2. NM_030937.4. [Q96S94-1]
XP_011540523.1. XM_011542221.2. [Q96S94-3]
XP_016857911.1. XM_017002422.1. [Q96S94-3]
UniGeneiHs.515704.

3D structure databases

ProteinModelPortaliQ96S94.
SMRiQ96S94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123566. 49 interactors.
IntActiQ96S94. 23 interactors.
STRINGi9606.ENSP00000383611.

PTM databases

iPTMnetiQ96S94.
PhosphoSitePlusiQ96S94.

Polymorphism and mutation databases

BioMutaiCCNL2.
DMDMi74752124.

Proteomic databases

EPDiQ96S94.
MaxQBiQ96S94.
PaxDbiQ96S94.
PeptideAtlasiQ96S94.
PRIDEiQ96S94.
TopDownProteomicsiQ96S94-1. [Q96S94-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400809; ENSP00000383611; ENSG00000221978. [Q96S94-1]
ENST00000408918; ENSP00000386158; ENSG00000221978. [Q96S94-5]
ENST00000481223; ENSP00000423734; ENSG00000221978. [Q96S94-4]
ENST00000488340; ENSP00000424647; ENSG00000221978. [Q96S94-2]
GeneIDi81669.
KEGGihsa:81669.
UCSCiuc001afi.3. human. [Q96S94-1]
uc057beg.1. human.

Organism-specific databases

CTDi81669.
DisGeNETi81669.
GeneCardsiCCNL2.
HGNCiHGNC:20570. CCNL2.
HPAiHPA053137.
MIMi613482. gene.
neXtProtiNX_Q96S94.
OpenTargetsiENSG00000221978.
PharmGKBiPA134973681.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0835. Eukaryota.
COG5333. LUCA.
GeneTreeiENSGT00760000119191.
HOVERGENiHBG056044.
InParanoidiQ96S94.
OMAiTGHRYER.
OrthoDBiEOG091G0BW9.
PhylomeDBiQ96S94.
TreeFamiTF101011.

Enzyme and pathway databases

BioCyciZFISH:G66-32396-MONOMER.
SignaLinkiQ96S94.
SIGNORiQ96S94.

Miscellaneous databases

ChiTaRSiCCNL2. human.
GeneWikiiCCNL2.
GenomeRNAii81669.
PROiQ96S94.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000221978.
CleanExiHS_CCNL2.
ExpressionAtlasiQ96S94. baseline and differential.
GenevisibleiQ96S94. HS.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015429. Cyclin_L/T.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF036580. Cyclin_L. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCCNL2_HUMAN
AccessioniPrimary (citable) accession number: Q96S94
Secondary accession number(s): A0A024R072
, A0A024R077, A0A0C4DGC4, A8K8A3, B1B152, F2Z3J5, Q5T2N5, Q5T2N6, Q6IQ12, Q7Z4Z8, Q8N3C9, Q8N3D5, Q8NHE3, Q8TEL0, Q96B00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.