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Protein

Cyclin-L2

Gene

CCNL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ96S94
SIGNORiQ96S94

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-L2
Alternative name(s):
Paneth cell-enhanced expression protein
Gene namesi
Name:CCNL2
ORF Names:SB138
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000221978.11
HGNCiHGNC:20570 CCNL2
MIMi613482 gene
neXtProtiNX_Q96S94

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi81669
OpenTargetsiENSG00000221978
PharmGKBiPA134973681

Polymorphism and mutation databases

BioMutaiCCNL2
DMDMi74752124

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000804872 – 520Cyclin-L2Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei369PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96S94
MaxQBiQ96S94
PaxDbiQ96S94
PeptideAtlasiQ96S94
PRIDEiQ96S94
TopDownProteomicsiQ96S94-1 [Q96S94-1]

PTM databases

iPTMnetiQ96S94
PhosphoSitePlusiQ96S94

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiENSG00000221978
CleanExiHS_CCNL2
ExpressionAtlasiQ96S94 baseline and differential
GenevisibleiQ96S94 HS

Organism-specific databases

HPAiHPA053137

Interactioni

Subunit structurei

Interacts with CDK11A, CDK11B, CDK12, CDK13 and POLR2A, the hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II (PubMed:14684736, PubMed:18216018). May form a ternary complex with CDK11B and casein kinase II (CKII) (PubMed:18216018). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7 (PubMed:14684736, PubMed:18216018).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi12356651 interactors.
IntActiQ96S94 30 interactors.
MINTiQ96S94
STRINGi9606.ENSP00000383611

Structurei

3D structure databases

ProteinModelPortaliQ96S94
SMRiQ96S94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 185Cyclin-like 1Add BLAST103
Regioni198 – 282Cyclin-like 2Add BLAST85
Regioni385 – 423RSAdd BLAST39

Domaini

Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).By similarity

Sequence similaritiesi

Belongs to the cyclin family. Cyclin L subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0835 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00760000119191
HOVERGENiHBG056044
InParanoidiQ96S94
OMAiTGHRYER
OrthoDBiEOG091G0BW9
PhylomeDBiQ96S94
TreeFamiTF101011

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96S94-1) [UniParc]FASTAAdd to basket
Also known as: cyclin L2alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAAAAGA AGSAAPAAAA GAPGSGGAPS GSQGVLIGDR LYSGVLITLE
60 70 80 90 100
NCLLPDDKLR FTPSMSSGLD TDTETDLRVV GCELIQAAGI LLRLPQVAMA
110 120 130 140 150
TGQVLFQRFF YTKSFVKHSM EHVSMACVHL ASKIEEAPRR IRDVINVFHR
160 170 180 190 200
LRQLRDKKKP VPLLLDQDYV NLKNQIIKAE RRVLKELGFC VHVKHPHKII
210 220 230 240 250
VMYLQVLECE RNQHLVQTSW NYMNDSLRTD VFVRFQPESI ACACIYLAAR
260 270 280 290 300
TLEIPLPNRP HWFLLFGATE EEIQEICLKI LQLYARKKVD LTHLEGEVEK
310 320 330 340 350
RKHAIEEAKA QARGLLPGGT QVLDGTSGFS PAPKLVESPK EGKGSKPSPL
360 370 380 390 400
SVKNTKRRLE GAKKAKADSP VNGLPKGRES RSRSRSREQS YSRSPSRSAS
410 420 430 440 450
PKRRKSDSGS TSGGSKSQSR SRSRSDSPPR QAPRSAPYKG SEIRGSRKSK
460 470 480 490 500
DCKYPQKPHK SRSRSSSRSR SRSRERADNP GKYKKKSHYY RDQRRERSRS
510 520
YERTGRRYER DHPGHSRHRR
Length:520
Mass (Da):58,147
Last modified:December 1, 2001 - v1
Checksum:i4341E55D03D7B0E0
GO
Isoform 2 (identifier: Q96S94-2) [UniParc]FASTAAdd to basket
Also known as: CCNL2s

The sequence of this isoform differs from the canonical sequence as follows:
     221-227: NYMNDSL → VASEGIT
     228-520: Missing.

Show »
Length:227
Mass (Da):24,707
Checksum:iD36EC47ABC9FB2FE
GO
Isoform 3 (identifier: Q96S94-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.

Show »
Length:298
Mass (Da):33,839
Checksum:i96FA9D04F9CCB9F7
GO
Isoform 4 (identifier: Q96S94-4) [UniParc]FASTAAdd to basket
Also known as: cyclin L2betaB

The sequence of this isoform differs from the canonical sequence as follows:
     221-236: NYMNDSLRTDVFVRFQ → VASEDPLLKWDSWQRL
     237-520: Missing.

Show »
Length:236
Mass (Da):25,974
Checksum:iD67DF36F25A43915
GO
Isoform 5 (identifier: Q96S94-5) [UniParc]FASTAAdd to basket
Also known as: cyclin L2betaA

The sequence of this isoform differs from the canonical sequence as follows:
     221-226: NYMNDS → VASEGK
     227-520: Missing.

Show »
Length:226
Mass (Da):24,621
Checksum:i2DA47ABC9FB2FED8
GO

Sequence cautioni

The sequence AAH71622 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB84938 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71T → S in AAH16333 (PubMed:15489334).Curated1
Sequence conflicti324 – 325DG → MS in AAP97201 (Ref. 8) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0161321 – 222Missing in isoform 3. 2 PublicationsAdd BLAST222
Alternative sequenceiVSP_058301221 – 236NYMND…FVRFQ → VASEDPLLKWDSWQRL in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_058302221 – 227NYMNDSL → VASEGIT in isoform 2. 7
Alternative sequenceiVSP_016130221 – 226NYMNDS → VASEGK in isoform 5. 4 Publications6
Alternative sequenceiVSP_016131227 – 520Missing in isoform 5. 4 PublicationsAdd BLAST294
Alternative sequenceiVSP_058303228 – 520Missing in isoform 2. Add BLAST293
Alternative sequenceiVSP_058304237 – 520Missing in isoform 4. Add BLAST284

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037150 mRNA Translation: AAK67631.1
AY116620 mRNA Translation: AAM76789.1
AK074112 mRNA Translation: BAB84938.1 Different initiation.
AK056120 mRNA No translation available.
AK027770 mRNA Translation: BAG51376.1
AK292268 mRNA Translation: BAF84957.1
AL391244 Genomic DNA No translation available.
CR628411 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56213.1
CH471183 Genomic DNA Translation: EAW56215.1
CH471183 Genomic DNA Translation: EAW56216.1
CH471183 Genomic DNA Translation: EAW56217.1
BC016333 mRNA Translation: AAH16333.1
BC071622 mRNA Translation: AAH71622.2 Different initiation.
AL834432 mRNA Translation: CAD39092.1
AL834441 mRNA Translation: CAD39101.1
AF087903 mRNA Translation: AAP97201.1
CCDSiCCDS30557.1 [Q96S94-1]
CCDS30558.1 [Q96S94-5]
RefSeqiNP_001034666.1, NM_001039577.3 [Q96S94-5]
NP_001307082.1, NM_001320153.1 [Q96S94-3]
NP_001307084.1, NM_001320155.1 [Q96S94-3]
NP_112199.2, NM_030937.4 [Q96S94-1]
XP_011540523.1, XM_011542221.2
XP_016857911.1, XM_017002422.1
UniGeneiHs.515704

Genome annotation databases

EnsembliENST00000400809; ENSP00000383611; ENSG00000221978 [Q96S94-1]
ENST00000408918; ENSP00000386158; ENSG00000221978 [Q96S94-5]
ENST00000481223; ENSP00000423734; ENSG00000221978 [Q96S94-4]
ENST00000488340; ENSP00000424647; ENSG00000221978 [Q96S94-2]
GeneIDi81669
KEGGihsa:81669
UCSCiuc001afi.3 human [Q96S94-1]
uc057beg.1 human

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCNL2_HUMAN
AccessioniPrimary (citable) accession number: Q96S94
Secondary accession number(s): A0A024R072
, A0A024R077, A0A0C4DGC4, A8K8A3, B1B152, F2Z3J5, Q5T2N5, Q5T2N6, Q6IQ12, Q7Z4Z8, Q8N3C9, Q8N3D5, Q8NHE3, Q8TEL0, Q96B00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome