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Q96S94

- CCNL2_HUMAN

UniProt

Q96S94 - CCNL2_HUMAN

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Protein

Cyclin-L2

Gene

CCNL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Also modulates the expression of critical apoptotic factor, leading to cell apoptosis.1 Publication

GO - Biological processi

  1. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. RNA processing Source: InterPro
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ96S94.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-L2
Alternative name(s):
Paneth cell-enhanced expression protein
Gene namesi
Name:CCNL2
ORF Names:SB138
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:20570. CCNL2.

Subcellular locationi

Nucleus speckle 1 Publication

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134973681.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 520519Cyclin-L2PRO_0000080487Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei330 – 3301Phosphoserine3 Publications
Modified residuei338 – 3381Phosphoserine1 Publication
Modified residuei348 – 3481Phosphoserine1 Publication
Modified residuei351 – 3511Phosphoserine1 Publication
Modified residuei369 – 3691Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96S94.
PaxDbiQ96S94.
PRIDEiQ96S94.

PTM databases

PhosphoSiteiQ96S94.

Expressioni

Tissue specificityi

Ubiquitously expressed, with a higher expression level observed in ovary, heart, liver and pancreas.1 Publication

Gene expression databases

BgeeiQ96S94.
CleanExiHS_CCNL2.
ExpressionAtlasiQ96S94. baseline and differential.
GenevestigatoriQ96S94.

Organism-specific databases

HPAiHPA053137.

Interactioni

Subunit structurei

Interacts with CDK11A, CDK11B, CDK12, CDK13, SFRS2, SFRS7 and POLR2A, the hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II.1 Publication

Protein-protein interaction databases

BioGridi123566. 35 interactions.
IntActiQ96S94. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96S94.
SMRiQ96S94. Positions 52-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 185103Cyclin-like 1Add
BLAST
Regioni198 – 28285Cyclin-like 2Add
BLAST
Regioni385 – 42339RSAdd
BLAST

Domaini

Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).By similarity

Sequence similaritiesi

Belongs to the cyclin family. Cyclin L subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5333.
GeneTreeiENSGT00760000119191.
HOVERGENiHBG056044.
InParanoidiQ96S94.
OMAiDQEYVNL.
PhylomeDBiQ96S94.
TreeFamiTF101011.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015429. Cyclin_C/H/T/L.
IPR017060. Cyclin_L.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10026. PTHR10026. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF036580. Cyclin_L. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96S94-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAAAAGA AGSAAPAAAA GAPGSGGAPS GSQGVLIGDR LYSGVLITLE
60 70 80 90 100
NCLLPDDKLR FTPSMSSGLD TDTETDLRVV GCELIQAAGI LLRLPQVAMA
110 120 130 140 150
TGQVLFQRFF YTKSFVKHSM EHVSMACVHL ASKIEEAPRR IRDVINVFHR
160 170 180 190 200
LRQLRDKKKP VPLLLDQDYV NLKNQIIKAE RRVLKELGFC VHVKHPHKII
210 220 230 240 250
VMYLQVLECE RNQHLVQTSW NYMNDSLRTD VFVRFQPESI ACACIYLAAR
260 270 280 290 300
TLEIPLPNRP HWFLLFGATE EEIQEICLKI LQLYARKKVD LTHLEGEVEK
310 320 330 340 350
RKHAIEEAKA QARGLLPGGT QVLDGTSGFS PAPKLVESPK EGKGSKPSPL
360 370 380 390 400
SVKNTKRRLE GAKKAKADSP VNGLPKGRES RSRSRSREQS YSRSPSRSAS
410 420 430 440 450
PKRRKSDSGS TSGGSKSQSR SRSRSDSPPR QAPRSAPYKG SEIRGSRKSK
460 470 480 490 500
DCKYPQKPHK SRSRSSSRSR SRSRERADNP GKYKKKSHYY RDQRRERSRS
510 520
YERTGRRYER DHPGHSRHRR
Length:520
Mass (Da):58,147
Last modified:December 1, 2001 - v1
Checksum:i4341E55D03D7B0E0
GO
Isoform 2 (identifier: Q96S94-2) [UniParc]FASTAAdd to Basket

Also known as: CCNL2s

The sequence of this isoform differs from the canonical sequence as follows:
     221-226: NYMNDS → VASEGK
     227-520: Missing.

Show »
Length:226
Mass (Da):24,621
Checksum:i2DA47ABC9FB2FED8
GO
Isoform 3 (identifier: Q96S94-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.

Show »
Length:298
Mass (Da):33,839
Checksum:i96FA9D04F9CCB9F7
GO

Sequence cautioni

The sequence AAH71622.2 differs from that shown. Reason: Erroneous initiation.
The sequence BAB84938.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711T → S in AAH16333. (PubMed:15489334)Curated
Sequence conflicti324 – 3252DG → MS in AAP97201. 1 PublicationCurated
Isoform 2 (identifier: Q96S94-2)
Sequence conflicti226 – 2261K → IT in AAM76789. (PubMed:14684736)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 222222Missing in isoform 3. 2 PublicationsVSP_016132Add
BLAST
Alternative sequencei221 – 2266NYMNDS → VASEGK in isoform 2. 4 PublicationsVSP_016130
Alternative sequencei227 – 520294Missing in isoform 2. 4 PublicationsVSP_016131Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY037150 mRNA. Translation: AAK67631.1.
AY116620 mRNA. Translation: AAM76789.1.
AK074112 mRNA. Translation: BAB84938.1. Different initiation.
AK027770 mRNA. Translation: BAG51376.1.
AK292268 mRNA. Translation: BAF84957.1.
AL391244 Genomic DNA. Translation: CAI22659.1.
AL391244, CR628411 Genomic DNA. Translation: CAI22660.2.
CR628411, AL391244 Genomic DNA. Translation: CAM12829.1.
CH471183 Genomic DNA. Translation: EAW56213.1.
CH471183 Genomic DNA. Translation: EAW56216.1.
BC016333 mRNA. Translation: AAH16333.1.
BC071622 mRNA. Translation: AAH71622.2. Different initiation.
AL834432 mRNA. Translation: CAD39092.1.
AL834441 mRNA. Translation: CAD39101.1.
AF087903 mRNA. Translation: AAP97201.1.
CCDSiCCDS30557.1. [Q96S94-1]
CCDS30558.1. [Q96S94-2]
RefSeqiNP_001034666.1. NM_001039577.3. [Q96S94-2]
NP_112199.2. NM_030937.4. [Q96S94-1]
XP_006710997.1. XM_006710934.1. [Q96S94-3]
UniGeneiHs.515704.

Genome annotation databases

EnsembliENST00000400809; ENSP00000383611; ENSG00000221978. [Q96S94-1]
ENST00000408918; ENSP00000386158; ENSG00000221978. [Q96S94-2]
ENST00000488340; ENSP00000424647; ENSG00000221978.
GeneIDi81669.
KEGGihsa:81669.
UCSCiuc001aff.1. human. [Q96S94-1]
uc021oep.1. human. [Q96S94-2]

Polymorphism databases

DMDMi74752124.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY037150 mRNA. Translation: AAK67631.1 .
AY116620 mRNA. Translation: AAM76789.1 .
AK074112 mRNA. Translation: BAB84938.1 . Different initiation.
AK027770 mRNA. Translation: BAG51376.1 .
AK292268 mRNA. Translation: BAF84957.1 .
AL391244 Genomic DNA. Translation: CAI22659.1 .
AL391244 , CR628411 Genomic DNA. Translation: CAI22660.2 .
CR628411 , AL391244 Genomic DNA. Translation: CAM12829.1 .
CH471183 Genomic DNA. Translation: EAW56213.1 .
CH471183 Genomic DNA. Translation: EAW56216.1 .
BC016333 mRNA. Translation: AAH16333.1 .
BC071622 mRNA. Translation: AAH71622.2 . Different initiation.
AL834432 mRNA. Translation: CAD39092.1 .
AL834441 mRNA. Translation: CAD39101.1 .
AF087903 mRNA. Translation: AAP97201.1 .
CCDSi CCDS30557.1. [Q96S94-1 ]
CCDS30558.1. [Q96S94-2 ]
RefSeqi NP_001034666.1. NM_001039577.3. [Q96S94-2 ]
NP_112199.2. NM_030937.4. [Q96S94-1 ]
XP_006710997.1. XM_006710934.1. [Q96S94-3 ]
UniGenei Hs.515704.

3D structure databases

ProteinModelPortali Q96S94.
SMRi Q96S94. Positions 52-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123566. 35 interactions.
IntActi Q96S94. 1 interaction.

PTM databases

PhosphoSitei Q96S94.

Polymorphism databases

DMDMi 74752124.

Proteomic databases

MaxQBi Q96S94.
PaxDbi Q96S94.
PRIDEi Q96S94.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000400809 ; ENSP00000383611 ; ENSG00000221978 . [Q96S94-1 ]
ENST00000408918 ; ENSP00000386158 ; ENSG00000221978 . [Q96S94-2 ]
ENST00000488340 ; ENSP00000424647 ; ENSG00000221978 .
GeneIDi 81669.
KEGGi hsa:81669.
UCSCi uc001aff.1. human. [Q96S94-1 ]
uc021oep.1. human. [Q96S94-2 ]

Organism-specific databases

CTDi 81669.
GeneCardsi GC01M001321.
HGNCi HGNC:20570. CCNL2.
HPAi HPA053137.
MIMi 613482. gene.
neXtProti NX_Q96S94.
PharmGKBi PA134973681.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5333.
GeneTreei ENSGT00760000119191.
HOVERGENi HBG056044.
InParanoidi Q96S94.
OMAi DQEYVNL.
PhylomeDBi Q96S94.
TreeFami TF101011.

Enzyme and pathway databases

SignaLinki Q96S94.

Miscellaneous databases

ChiTaRSi CCNL2. human.
GeneWikii CCNL2.
GenomeRNAii 81669.
NextBioi 72022.
PROi Q96S94.
SOURCEi Search...

Gene expression databases

Bgeei Q96S94.
CleanExi HS_CCNL2.
ExpressionAtlasi Q96S94. baseline and differential.
Genevestigatori Q96S94.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015429. Cyclin_C/H/T/L.
IPR017060. Cyclin_L.
IPR006671. Cyclin_N.
[Graphical view ]
PANTHERi PTHR10026. PTHR10026. 1 hit.
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF036580. Cyclin_L. 1 hit.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells."
    Yang L., Li N., Wang C., Yu Y., Yuan L., Zhang M., Cao X.
    J. Biol. Chem. 279:11639-11648(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH POLR2A; CDC2L; SFRS2 AND SFRS7.
    Tissue: Bone marrow.
  2. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Placenta and Testis.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Bone and Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-226 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 367-520.
    Tissue: Amygdala and Melanoma.
  8. "Cloning of a novel human cDNA homology to murine Paneth cell enhanced expression mRNA."
    Zhao E.P., Yu L., Wan Y.Z., Tu Q., Zheng L.H., Zhao S.Y.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 324-520.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330 AND SER-338, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330; SER-348; SER-351 AND SER-369, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCCNL2_HUMAN
AccessioniPrimary (citable) accession number: Q96S94
Secondary accession number(s): A8K8A3
, B1B152, Q5T2N5, Q5T2N6, Q6IQ12, Q7Z4Z8, Q8N3C9, Q8N3D5, Q8NHE3, Q8TEL0, Q96B00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3