Q96S86 (HPLN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hyaluronan and proteoglycan link protein 3

Gene names

Name:	HAPLN3
Synonyms:	EXLD1
ORF Names:	UNQ238/PRO271

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function in hyaluronic acid binding. Ref.1
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Tissue specificity	Widely expressed with highest levels in spleen and placenta. Ref.1
Sequence similarities	Belongs to the HAPLN family. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 2 Link domains.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Immunoglobulin domain Repeat Signal
Ligand	Hyaluronic acid
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	hyaluronic acid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 360	343	Hyaluronan and proteoglycan link protein 3		PRO_0000013190
Regions
	Domain	48 – 164	117	Ig-like V-type
	Domain	166 – 261	96	Link 1
	Domain	266 – 358	93	Link 2
Amino acid modifications
	Disulfide bond	70 ↔ 146		By similarity UniProtKB P03994
	Disulfide bond	188 ↔ 259		By similarity UniProtKB P03994
	Disulfide bond	212 ↔ 233		By similarity UniProtKB P03994
	Disulfide bond	286 ↔ 356		By similarity UniProtKB P03994
	Disulfide bond	311 ↔ 332		By similarity UniProtKB P03994

Sequences

	Sequence		Length	Mass (Da)
	Q96S86 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 3B72AE88D0D9E8DC	FASTA	360	40,894
	10 20 30 40 50 60 MGLLLLVPLL LLPGSYGLPF YNGFYYSNSA NDQNLGNGHG KDLLNGVKLV VETPEETLFT 70 80 90 100 110 120 YQGASVILPC RYRYEPALVS PRRVRVKWWK LSENGAPEKD VLVAIGLRHR SFGDYQGRVH 130 140 150 160 170 180 LRQDKEHDVS LEIQDLRLED YGRYRCEVID GLEDESGLVE LELRGVVFPY QSPNGRYQFN 190 200 210 220 230 240 FHEGQQVCAE QAAVVASFEQ LFRAWEEGLD WCNAGWLQDA TVQYPIMLPR QPCGGPGLAP 250 260 270 280 290 300 GVRSYGPRHR RLHRYDVFCF ATALKGRVYY LEHPEKLTLT EAREACQEDD ATIAKVGQLF 310 320 330 340 350 360 AAWKFHGLDR CDAGWLADGS VRYPVVHPHP NCGPPEPGVR SFGFPDPQSR LYGVYCYRQH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links." Spicer A.P., Joo A., Bowling R.A. Jr. J. Biol. Chem. 278:21083-21091(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	Li N., Zhang W., Wan T., Zhang M., Cao X. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY262759 mRNA. Translation: AAP22051.1. AY037161 mRNA. Translation: AAK67639.1. AY358500 mRNA. Translation: AAQ88864.1. AK292055 mRNA. Translation: BAF84744.1. CH471101 Genomic DNA. Translation: EAX02022.1. BC062320 mRNA. Translation: AAH62320.1.
IPI	IPI00045527.
RefSeq	NP_839946.1. NM_178232.2.
UniGene	Hs.447530.
3D structure databases
ProteinModelPortal	Q96S86.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96S86. 2 interactions.
STRING	9606.ENSP00000352606.
Polymorphism databases
DMDM	47605734.
Proteomic databases
PaxDb	Q96S86.
PRIDE	Q96S86.
Protocols and materials databases
DNASU	145864.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359595; ENSP00000352606; ENSG00000140511.
GeneID	145864.
KEGG	hsa:145864.
UCSC	uc002bnc.3. human.
Organism-specific databases
CTD	145864.
GeneCards	GC15M089420.
HGNC	HGNC:21446. HAPLN3.
HPA	HPA039237.
neXtProt	NX_Q96S86.
PharmGKB	PA134919215.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG147414.
HOGENOM	HOG000234353.
HOVERGEN	HBG051922.
InParanoid	Q96S86.
KO	K06852.
OMA	HRSFGDY.
OrthoDB	EOG4XKV76.
PhylomeDB	Q96S86.
Gene expression databases
ArrayExpress	Q96S86.
Bgee	Q96S86.
CleanEx	HS_HAPLN3.
Genevestigator	Q96S86.
GermOnline	ENSG00000140511. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.10.100.10. 2 hits.
InterPro	IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. IPR000538. Link. [Graphical view]
Pfam	PF07686. V-set. 1 hit. PF00193. Xlink. 2 hits. [Graphical view]
PRINTS	PR01265. LINKMODULE.
SMART	SM00409. IG. 1 hit. SM00445. LINK. 2 hits. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 2 hits.
PROSITE	PS50835. IG_LIKE. 1 hit. PS01241. LINK_1. 2 hits. PS50963. LINK_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HAPLN3. human.
GenomeRNAi	145864.
NextBio	85216.

Entry information

Entry name

HPLN3_HUMAN

Accession

Primary (citable) accession number: Q96S86
Secondary accession number(s): A8K7P0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.