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Protein

Hyaluronan and proteoglycan link protein 3

Gene

HAPLN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function in hyaluronic acid binding.1 Publication

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: GO_Central
  2. hyaluronic acid binding Source: GO_Central

GO - Biological processi

  1. cell adhesion Source: GO_Central
  2. central nervous system development Source: GO_Central
  3. skeletal system development Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 3
Gene namesi
Name:HAPLN3
Synonyms:EXLD1
ORF Names:UNQ238/PRO271
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:21446. HAPLN3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
  2. proteinaceous extracellular matrix Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919215.

Chemistry

DrugBankiDB08818. Hyaluronan.

Polymorphism and mutation databases

BioMutaiHAPLN3.
DMDMi47605734.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 360343Hyaluronan and proteoglycan link protein 3Sequence AnalysisPRO_0000013190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi70 ↔ 146By similarity
Disulfide bondi188 ↔ 259By similarity
Disulfide bondi212 ↔ 233By similarity
Disulfide bondi286 ↔ 356By similarity
Disulfide bondi311 ↔ 332By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96S86.
PRIDEiQ96S86.

Expressioni

Tissue specificityi

Widely expressed with highest levels in spleen and placenta.1 Publication

Gene expression databases

BgeeiQ96S86.
CleanExiHS_HAPLN3.
ExpressionAtlasiQ96S86. baseline and differential.
GenevestigatoriQ96S86.

Organism-specific databases

HPAiHPA039237.

Interactioni

Protein-protein interaction databases

BioGridi126950. 2 interactions.
IntActiQ96S86. 2 interactions.
STRINGi9606.ENSP00000352606.

Structurei

3D structure databases

ProteinModelPortaliQ96S86.
SMRiQ96S86. Positions 49-148, 167-260, 276-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 164117Ig-like V-typeCuratedAdd
BLAST
Domaini166 – 26196Link 1PROSITE-ProRule annotationCuratedAdd
BLAST
Domaini266 – 35893Link 2PROSITE-ProRule annotationCuratedAdd
BLAST

Sequence similaritiesi

Belongs to the HAPLN family.Curated
Contains 2 Link domains.PROSITE-ProRule annotationCurated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG147414.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ96S86.
KOiK06852.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ96S86.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96S86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLLLVPLL LLPGSYGLPF YNGFYYSNSA NDQNLGNGHG KDLLNGVKLV
60 70 80 90 100
VETPEETLFT YQGASVILPC RYRYEPALVS PRRVRVKWWK LSENGAPEKD
110 120 130 140 150
VLVAIGLRHR SFGDYQGRVH LRQDKEHDVS LEIQDLRLED YGRYRCEVID
160 170 180 190 200
GLEDESGLVE LELRGVVFPY QSPNGRYQFN FHEGQQVCAE QAAVVASFEQ
210 220 230 240 250
LFRAWEEGLD WCNAGWLQDA TVQYPIMLPR QPCGGPGLAP GVRSYGPRHR
260 270 280 290 300
RLHRYDVFCF ATALKGRVYY LEHPEKLTLT EAREACQEDD ATIAKVGQLF
310 320 330 340 350
AAWKFHGLDR CDAGWLADGS VRYPVVHPHP NCGPPEPGVR SFGFPDPQSR
360
LYGVYCYRQH
Length:360
Mass (Da):40,894
Last modified:December 1, 2001 - v1
Checksum:i3B72AE88D0D9E8DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262759 mRNA. Translation: AAP22051.1.
AY037161 mRNA. Translation: AAK67639.1.
AY358500 mRNA. Translation: AAQ88864.1.
AK292055 mRNA. Translation: BAF84744.1.
CH471101 Genomic DNA. Translation: EAX02022.1.
BC062320 mRNA. Translation: AAH62320.1.
CCDSiCCDS10346.1.
RefSeqiNP_839946.1. NM_178232.2.
UniGeneiHs.447530.

Genome annotation databases

GeneIDi145864.
KEGGihsa:145864.
UCSCiuc002bnc.3. human.

Polymorphism and mutation databases

BioMutaiHAPLN3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262759 mRNA. Translation: AAP22051.1.
AY037161 mRNA. Translation: AAK67639.1.
AY358500 mRNA. Translation: AAQ88864.1.
AK292055 mRNA. Translation: BAF84744.1.
CH471101 Genomic DNA. Translation: EAX02022.1.
BC062320 mRNA. Translation: AAH62320.1.
CCDSiCCDS10346.1.
RefSeqiNP_839946.1. NM_178232.2.
UniGeneiHs.447530.

3D structure databases

ProteinModelPortaliQ96S86.
SMRiQ96S86. Positions 49-148, 167-260, 276-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126950. 2 interactions.
IntActiQ96S86. 2 interactions.
STRINGi9606.ENSP00000352606.

Chemistry

DrugBankiDB08818. Hyaluronan.

Polymorphism and mutation databases

BioMutaiHAPLN3.
DMDMi47605734.

Proteomic databases

PaxDbiQ96S86.
PRIDEiQ96S86.

Protocols and materials databases

DNASUi145864.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi145864.
KEGGihsa:145864.
UCSCiuc002bnc.3. human.

Organism-specific databases

CTDi145864.
GeneCardsiGC15M089420.
HGNCiHGNC:21446. HAPLN3.
HPAiHPA039237.
neXtProtiNX_Q96S86.
PharmGKBiPA134919215.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG147414.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ96S86.
KOiK06852.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ96S86.
TreeFamiTF332134.

Miscellaneous databases

ChiTaRSiHAPLN3. human.
GenomeRNAii145864.
NextBioi85216.
PROiQ96S86.

Gene expression databases

BgeeiQ96S86.
CleanExiHS_HAPLN3.
ExpressionAtlasiQ96S86. baseline and differential.
GenevestigatoriQ96S86.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links."
    Spicer A.P., Joo A., Bowling R.A. Jr.
    J. Biol. Chem. 278:21083-21091(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Li N., Zhang W., Wan T., Zhang M., Cao X.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PancreasImported.

Entry informationi

Entry nameiHPLN3_HUMAN
AccessioniPrimary (citable) accession number: Q96S86
Secondary accession number(s): A8K7P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: April 29, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.