Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hyaluronan and proteoglycan link protein 3

Gene

HAPLN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function in hyaluronic acid binding.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140511-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 3
Gene namesi
Name:HAPLN3
Synonyms:EXLD1
ORF Names:UNQ238/PRO271
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:21446. HAPLN3.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • proteinaceous extracellular matrix Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi145864.
OpenTargetsiENSG00000140511.
PharmGKBiPA134919215.

Chemistry databases

DrugBankiDB08818. Hyaluronic acid.

Polymorphism and mutation databases

BioMutaiHAPLN3.
DMDMi47605734.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001319018 – 360Hyaluronan and proteoglycan link protein 3Sequence analysisAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi70 ↔ 146By similarity
Disulfide bondi188 ↔ 259By similarity
Disulfide bondi212 ↔ 233By similarity
Disulfide bondi286 ↔ 356By similarity
Disulfide bondi311 ↔ 332By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ96S86.
PaxDbiQ96S86.
PeptideAtlasiQ96S86.
PRIDEiQ96S86.

PTM databases

iPTMnetiQ96S86.
PhosphoSitePlusiQ96S86.

Expressioni

Tissue specificityi

Widely expressed with highest levels in spleen and placenta.1 Publication

Gene expression databases

BgeeiENSG00000140511.
CleanExiHS_HAPLN3.
ExpressionAtlasiQ96S86. baseline and differential.
GenevisibleiQ96S86. HS.

Organism-specific databases

HPAiHPA039237.

Interactioni

Protein-protein interaction databases

BioGridi126950. 12 interactors.
IntActiQ96S86. 2 interactors.
STRINGi9606.ENSP00000352606.

Structurei

3D structure databases

ProteinModelPortaliQ96S86.
SMRiQ96S86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 164Ig-like V-typeCuratedAdd BLAST117
Domaini166 – 261Link 1PROSITE-ProRule annotationCuratedAdd BLAST96
Domaini266 – 358Link 2PROSITE-ProRule annotationCuratedAdd BLAST93

Sequence similaritiesi

Belongs to the HAPLN family.Curated
Contains 2 Link domains.PROSITE-ProRule annotationCurated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IG4T. Eukaryota.
ENOG410Z8AC. LUCA.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ96S86.
KOiK06852.
PhylomeDBiQ96S86.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96S86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLLLVPLL LLPGSYGLPF YNGFYYSNSA NDQNLGNGHG KDLLNGVKLV
60 70 80 90 100
VETPEETLFT YQGASVILPC RYRYEPALVS PRRVRVKWWK LSENGAPEKD
110 120 130 140 150
VLVAIGLRHR SFGDYQGRVH LRQDKEHDVS LEIQDLRLED YGRYRCEVID
160 170 180 190 200
GLEDESGLVE LELRGVVFPY QSPNGRYQFN FHEGQQVCAE QAAVVASFEQ
210 220 230 240 250
LFRAWEEGLD WCNAGWLQDA TVQYPIMLPR QPCGGPGLAP GVRSYGPRHR
260 270 280 290 300
RLHRYDVFCF ATALKGRVYY LEHPEKLTLT EAREACQEDD ATIAKVGQLF
310 320 330 340 350
AAWKFHGLDR CDAGWLADGS VRYPVVHPHP NCGPPEPGVR SFGFPDPQSR
360
LYGVYCYRQH
Length:360
Mass (Da):40,894
Last modified:December 1, 2001 - v1
Checksum:i3B72AE88D0D9E8DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262759 mRNA. Translation: AAP22051.1.
AY037161 mRNA. Translation: AAK67639.1.
AY358500 mRNA. Translation: AAQ88864.1.
AK292055 mRNA. Translation: BAF84744.1.
CH471101 Genomic DNA. Translation: EAX02022.1.
BC062320 mRNA. Translation: AAH62320.1.
CCDSiCCDS10346.1.
RefSeqiNP_001294881.1. NM_001307952.1.
NP_839946.1. NM_178232.3.
UniGeneiHs.447530.

Genome annotation databases

EnsembliENST00000359595; ENSP00000352606; ENSG00000140511.
GeneIDi145864.
KEGGihsa:145864.
UCSCiuc002bnc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262759 mRNA. Translation: AAP22051.1.
AY037161 mRNA. Translation: AAK67639.1.
AY358500 mRNA. Translation: AAQ88864.1.
AK292055 mRNA. Translation: BAF84744.1.
CH471101 Genomic DNA. Translation: EAX02022.1.
BC062320 mRNA. Translation: AAH62320.1.
CCDSiCCDS10346.1.
RefSeqiNP_001294881.1. NM_001307952.1.
NP_839946.1. NM_178232.3.
UniGeneiHs.447530.

3D structure databases

ProteinModelPortaliQ96S86.
SMRiQ96S86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126950. 12 interactors.
IntActiQ96S86. 2 interactors.
STRINGi9606.ENSP00000352606.

Chemistry databases

DrugBankiDB08818. Hyaluronic acid.

PTM databases

iPTMnetiQ96S86.
PhosphoSitePlusiQ96S86.

Polymorphism and mutation databases

BioMutaiHAPLN3.
DMDMi47605734.

Proteomic databases

EPDiQ96S86.
PaxDbiQ96S86.
PeptideAtlasiQ96S86.
PRIDEiQ96S86.

Protocols and materials databases

DNASUi145864.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359595; ENSP00000352606; ENSG00000140511.
GeneIDi145864.
KEGGihsa:145864.
UCSCiuc002bnc.4. human.

Organism-specific databases

CTDi145864.
DisGeNETi145864.
GeneCardsiHAPLN3.
HGNCiHGNC:21446. HAPLN3.
HPAiHPA039237.
neXtProtiNX_Q96S86.
OpenTargetsiENSG00000140511.
PharmGKBiPA134919215.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG4T. Eukaryota.
ENOG410Z8AC. LUCA.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ96S86.
KOiK06852.
PhylomeDBiQ96S86.
TreeFamiTF332134.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140511-MONOMER.

Miscellaneous databases

ChiTaRSiHAPLN3. human.
GenomeRNAii145864.
PROiQ96S86.

Gene expression databases

BgeeiENSG00000140511.
CleanExiHS_HAPLN3.
ExpressionAtlasiQ96S86. baseline and differential.
GenevisibleiQ96S86. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHPLN3_HUMAN
AccessioniPrimary (citable) accession number: Q96S86
Secondary accession number(s): A8K7P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.