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Q96S86

- HPLN3_HUMAN

UniProt

Q96S86 - HPLN3_HUMAN

Protein

Hyaluronan and proteoglycan link protein 3

Gene

HAPLN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May function in hyaluronic acid binding.1 Publication

    GO - Molecular functioni

    1. hyaluronic acid binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell adhesion Source: InterPro

    Keywords - Ligandi

    Hyaluronic acid

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronan and proteoglycan link protein 3
    Gene namesi
    Name:HAPLN3
    Synonyms:EXLD1
    ORF Names:UNQ238/PRO271
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:21446. HAPLN3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134919215.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 360343Hyaluronan and proteoglycan link protein 3Sequence AnalysisPRO_0000013190Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi70 ↔ 146By similarity
    Disulfide bondi188 ↔ 259By similarity
    Disulfide bondi212 ↔ 233By similarity
    Disulfide bondi286 ↔ 356By similarity
    Disulfide bondi311 ↔ 332By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ96S86.
    PRIDEiQ96S86.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in spleen and placenta.1 Publication

    Gene expression databases

    ArrayExpressiQ96S86.
    BgeeiQ96S86.
    CleanExiHS_HAPLN3.
    GenevestigatoriQ96S86.

    Organism-specific databases

    HPAiHPA039237.

    Interactioni

    Protein-protein interaction databases

    IntActiQ96S86. 2 interactions.
    STRINGi9606.ENSP00000352606.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96S86.
    SMRiQ96S86. Positions 49-148, 167-260, 276-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 164117Ig-like V-typeCuratedAdd
    BLAST
    Domaini166 – 26196Link 1CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini266 – 35893Link 2CuratedPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HAPLN family.Curated
    Contains 2 Link domains.CuratedPROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG147414.
    HOGENOMiHOG000234353.
    HOVERGENiHBG051922.
    InParanoidiQ96S86.
    KOiK06852.
    OrthoDBiEOG7ZWD1D.
    PhylomeDBiQ96S86.
    TreeFamiTF332134.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.100.10. 2 hits.
    InterProiIPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR000538. Link.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    PF00193. Xlink. 2 hits.
    [Graphical view]
    PRINTSiPR01265. LINKMODULE.
    SMARTiSM00409. IG. 1 hit.
    SM00445. LINK. 2 hits.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 2 hits.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS01241. LINK_1. 2 hits.
    PS50963. LINK_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96S86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLLLLVPLL LLPGSYGLPF YNGFYYSNSA NDQNLGNGHG KDLLNGVKLV    50
    VETPEETLFT YQGASVILPC RYRYEPALVS PRRVRVKWWK LSENGAPEKD 100
    VLVAIGLRHR SFGDYQGRVH LRQDKEHDVS LEIQDLRLED YGRYRCEVID 150
    GLEDESGLVE LELRGVVFPY QSPNGRYQFN FHEGQQVCAE QAAVVASFEQ 200
    LFRAWEEGLD WCNAGWLQDA TVQYPIMLPR QPCGGPGLAP GVRSYGPRHR 250
    RLHRYDVFCF ATALKGRVYY LEHPEKLTLT EAREACQEDD ATIAKVGQLF 300
    AAWKFHGLDR CDAGWLADGS VRYPVVHPHP NCGPPEPGVR SFGFPDPQSR 350
    LYGVYCYRQH 360
    Length:360
    Mass (Da):40,894
    Last modified:December 1, 2001 - v1
    Checksum:i3B72AE88D0D9E8DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY262759 mRNA. Translation: AAP22051.1.
    AY037161 mRNA. Translation: AAK67639.1.
    AY358500 mRNA. Translation: AAQ88864.1.
    AK292055 mRNA. Translation: BAF84744.1.
    CH471101 Genomic DNA. Translation: EAX02022.1.
    BC062320 mRNA. Translation: AAH62320.1.
    CCDSiCCDS10346.1.
    RefSeqiNP_839946.1. NM_178232.2.
    UniGeneiHs.447530.

    Genome annotation databases

    EnsembliENST00000359595; ENSP00000352606; ENSG00000140511.
    GeneIDi145864.
    KEGGihsa:145864.
    UCSCiuc002bnc.3. human.

    Polymorphism databases

    DMDMi47605734.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY262759 mRNA. Translation: AAP22051.1 .
    AY037161 mRNA. Translation: AAK67639.1 .
    AY358500 mRNA. Translation: AAQ88864.1 .
    AK292055 mRNA. Translation: BAF84744.1 .
    CH471101 Genomic DNA. Translation: EAX02022.1 .
    BC062320 mRNA. Translation: AAH62320.1 .
    CCDSi CCDS10346.1.
    RefSeqi NP_839946.1. NM_178232.2.
    UniGenei Hs.447530.

    3D structure databases

    ProteinModelPortali Q96S86.
    SMRi Q96S86. Positions 49-148, 167-260, 276-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q96S86. 2 interactions.
    STRINGi 9606.ENSP00000352606.

    Polymorphism databases

    DMDMi 47605734.

    Proteomic databases

    PaxDbi Q96S86.
    PRIDEi Q96S86.

    Protocols and materials databases

    DNASUi 145864.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359595 ; ENSP00000352606 ; ENSG00000140511 .
    GeneIDi 145864.
    KEGGi hsa:145864.
    UCSCi uc002bnc.3. human.

    Organism-specific databases

    CTDi 145864.
    GeneCardsi GC15M089420.
    HGNCi HGNC:21446. HAPLN3.
    HPAi HPA039237.
    neXtProti NX_Q96S86.
    PharmGKBi PA134919215.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147414.
    HOGENOMi HOG000234353.
    HOVERGENi HBG051922.
    InParanoidi Q96S86.
    KOi K06852.
    OrthoDBi EOG7ZWD1D.
    PhylomeDBi Q96S86.
    TreeFami TF332134.

    Miscellaneous databases

    ChiTaRSi HAPLN3. human.
    GenomeRNAii 145864.
    NextBioi 85216.
    PROi Q96S86.

    Gene expression databases

    ArrayExpressi Q96S86.
    Bgeei Q96S86.
    CleanExi HS_HAPLN3.
    Genevestigatori Q96S86.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.100.10. 2 hits.
    InterProi IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR000538. Link.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    PF00193. Xlink. 2 hits.
    [Graphical view ]
    PRINTSi PR01265. LINKMODULE.
    SMARTi SM00409. IG. 1 hit.
    SM00445. LINK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 2 hits.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS01241. LINK_1. 2 hits.
    PS50963. LINK_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links."
      Spicer A.P., Joo A., Bowling R.A. Jr.
      J. Biol. Chem. 278:21083-21091(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. Li N., Zhang W., Wan T., Zhang M., Cao X.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PancreasImported.

    Entry informationi

    Entry nameiHPLN3_HUMAN
    AccessioniPrimary (citable) accession number: Q96S86
    Secondary accession number(s): A8K7P0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3