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Q96S86

- HPLN3_HUMAN

UniProt

Q96S86 - HPLN3_HUMAN

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Protein

Hyaluronan and proteoglycan link protein 3

Gene

HAPLN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May function in hyaluronic acid binding.1 Publication

GO - Molecular functioni

  1. hyaluronic acid binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 3
Gene namesi
Name:HAPLN3
Synonyms:EXLD1
ORF Names:UNQ238/PRO271
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:21446. HAPLN3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
  2. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919215.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 360343Hyaluronan and proteoglycan link protein 3Sequence AnalysisPRO_0000013190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi70 ↔ 146By similarity
Disulfide bondi188 ↔ 259By similarity
Disulfide bondi212 ↔ 233By similarity
Disulfide bondi286 ↔ 356By similarity
Disulfide bondi311 ↔ 332By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96S86.
PRIDEiQ96S86.

Expressioni

Tissue specificityi

Widely expressed with highest levels in spleen and placenta.1 Publication

Gene expression databases

BgeeiQ96S86.
CleanExiHS_HAPLN3.
ExpressionAtlasiQ96S86. baseline and differential.
GenevestigatoriQ96S86.

Organism-specific databases

HPAiHPA039237.

Interactioni

Protein-protein interaction databases

BioGridi126950. 2 interactions.
IntActiQ96S86. 2 interactions.
STRINGi9606.ENSP00000352606.

Structurei

3D structure databases

ProteinModelPortaliQ96S86.
SMRiQ96S86. Positions 49-148, 167-260, 276-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 164117Ig-like V-typeCuratedAdd
BLAST
Domaini166 – 26196Link 1CuratedPROSITE-ProRule annotationAdd
BLAST
Domaini266 – 35893Link 2CuratedPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the HAPLN family.Curated
Contains 2 Link domains.CuratedPROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG147414.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ96S86.
KOiK06852.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ96S86.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96S86 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLLLLVPLL LLPGSYGLPF YNGFYYSNSA NDQNLGNGHG KDLLNGVKLV
60 70 80 90 100
VETPEETLFT YQGASVILPC RYRYEPALVS PRRVRVKWWK LSENGAPEKD
110 120 130 140 150
VLVAIGLRHR SFGDYQGRVH LRQDKEHDVS LEIQDLRLED YGRYRCEVID
160 170 180 190 200
GLEDESGLVE LELRGVVFPY QSPNGRYQFN FHEGQQVCAE QAAVVASFEQ
210 220 230 240 250
LFRAWEEGLD WCNAGWLQDA TVQYPIMLPR QPCGGPGLAP GVRSYGPRHR
260 270 280 290 300
RLHRYDVFCF ATALKGRVYY LEHPEKLTLT EAREACQEDD ATIAKVGQLF
310 320 330 340 350
AAWKFHGLDR CDAGWLADGS VRYPVVHPHP NCGPPEPGVR SFGFPDPQSR
360
LYGVYCYRQH
Length:360
Mass (Da):40,894
Last modified:December 1, 2001 - v1
Checksum:i3B72AE88D0D9E8DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY262759 mRNA. Translation: AAP22051.1.
AY037161 mRNA. Translation: AAK67639.1.
AY358500 mRNA. Translation: AAQ88864.1.
AK292055 mRNA. Translation: BAF84744.1.
CH471101 Genomic DNA. Translation: EAX02022.1.
BC062320 mRNA. Translation: AAH62320.1.
CCDSiCCDS10346.1.
RefSeqiNP_839946.1. NM_178232.2.
UniGeneiHs.447530.

Genome annotation databases

GeneIDi145864.
KEGGihsa:145864.
UCSCiuc002bnc.3. human.

Polymorphism databases

DMDMi47605734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY262759 mRNA. Translation: AAP22051.1 .
AY037161 mRNA. Translation: AAK67639.1 .
AY358500 mRNA. Translation: AAQ88864.1 .
AK292055 mRNA. Translation: BAF84744.1 .
CH471101 Genomic DNA. Translation: EAX02022.1 .
BC062320 mRNA. Translation: AAH62320.1 .
CCDSi CCDS10346.1.
RefSeqi NP_839946.1. NM_178232.2.
UniGenei Hs.447530.

3D structure databases

ProteinModelPortali Q96S86.
SMRi Q96S86. Positions 49-148, 167-260, 276-360.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126950. 2 interactions.
IntActi Q96S86. 2 interactions.
STRINGi 9606.ENSP00000352606.

Chemistry

DrugBanki DB08818. Hyaluronan.

Polymorphism databases

DMDMi 47605734.

Proteomic databases

PaxDbi Q96S86.
PRIDEi Q96S86.

Protocols and materials databases

DNASUi 145864.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 145864.
KEGGi hsa:145864.
UCSCi uc002bnc.3. human.

Organism-specific databases

CTDi 145864.
GeneCardsi GC15M089420.
HGNCi HGNC:21446. HAPLN3.
HPAi HPA039237.
neXtProti NX_Q96S86.
PharmGKBi PA134919215.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147414.
GeneTreei ENSGT00760000119025.
HOGENOMi HOG000234353.
HOVERGENi HBG051922.
InParanoidi Q96S86.
KOi K06852.
OrthoDBi EOG7ZWD1D.
PhylomeDBi Q96S86.
TreeFami TF332134.

Miscellaneous databases

ChiTaRSi HAPLN3. human.
GenomeRNAii 145864.
NextBioi 85216.
PROi Q96S86.

Gene expression databases

Bgeei Q96S86.
CleanExi HS_HAPLN3.
ExpressionAtlasi Q96S86. baseline and differential.
Genevestigatori Q96S86.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProi IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view ]
PRINTSi PR01265. LINKMODULE.
SMARTi SM00409. IG. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 2 hits.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links."
    Spicer A.P., Joo A., Bowling R.A. Jr.
    J. Biol. Chem. 278:21083-21091(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Li N., Zhang W., Wan T., Zhang M., Cao X.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PancreasImported.

Entry informationi

Entry nameiHPLN3_HUMAN
AccessioniPrimary (citable) accession number: Q96S86
Secondary accession number(s): A8K7P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3