Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin-like protein 7

Gene

UBL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein 7
Alternative name(s):
Bone marrow stromal cell ubiquitin-like protein
Short name:
BMSC-UbP
Ubiquitin-like protein SB132
Gene namesi
Name:UBL7
Synonyms:BMSCUBP
ORF Names:SB132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:28221. UBL7.

Pathology & Biotechi

Organism-specific databases

DisGeNETi84993.
OpenTargetsiENSG00000138629.
PharmGKBiPA142670645.

Polymorphism and mutation databases

BioMutaiUBL7.
DMDMi48474599.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002110211 – 380Ubiquitin-like protein 7Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96S82.
MaxQBiQ96S82.
PaxDbiQ96S82.
PeptideAtlasiQ96S82.
PRIDEiQ96S82.

PTM databases

iPTMnetiQ96S82.
PhosphoSitePlusiQ96S82.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in heart, skeletal muscle, testis, thyroid and adrenal gland.1 Publication

Inductioni

Down-regulated by phorbol myristate acetate (PMA) in bone marrow stroma cells.

Gene expression databases

BgeeiENSG00000138629.
CleanExiHS_UBL7.
ExpressionAtlasiQ96S82. baseline and differential.
GenevisibleiQ96S82. HS.

Organism-specific databases

HPAiHPA040423.
HPA041897.

Interactioni

Subunit structurei

Binds ubiquitin.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AP1G1O43747-25EBI-348604,EBI-10185819
CAPN7Q7Z4793EBI-348604,EBI-10213454
ERCC1P079924EBI-348604,EBI-750962
VBP1P617585EBI-348604,EBI-357430

Protein-protein interaction databases

BioGridi124418. 44 interactors.
IntActiQ96S82. 10 interactors.
MINTiMINT-1034167.
STRINGi9606.ENSP00000354883.

Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi339 – 346Combined sources8
Turni347 – 349Combined sources3
Helixi353 – 363Combined sources11
Helixi367 – 376Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CWBNMR-A336-380[»]
2DENNMR-A336-380[»]
ProteinModelPortaliQ96S82.
SMRiQ96S82.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96S82.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 98Ubiquitin-likePROSITE-ProRule annotationAdd BLAST81
Domaini333 – 377UBAPROSITE-ProRule annotationAdd BLAST45

Sequence similaritiesi

Contains 1 UBA domain.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ISS5. Eukaryota.
ENOG410YUJQ. LUCA.
GeneTreeiENSGT00390000015967.
HOVERGENiHBG054051.
InParanoidiQ96S82.
OMAiDDFHPSA.
OrthoDBiEOG091G0II5.
PhylomeDBiQ96S82.
TreeFamiTF327176.

Family and domain databases

InterProiIPR015940. UBA.
IPR009060. UBA-like.
IPR015496. Ubiquilin.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10677. PTHR10677. 1 hit.
PfamiPF00627. UBA. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00165. UBA. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50030. UBA. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96S82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSDWHLAV KLADQPLTPK SILRLPETEL GEYSLGGYSI SFLKQLIAGK
60 70 80 90 100
LQESVPDPEL IDLIYCGRKL KDDQTLDFYG IQPGSTVHVL RKSWPEPDQK
110 120 130 140 150
PEPVDKVAAM REFRVLHTAL HSSSSYREAV FKMLSNKESL DQIIVATPGL
160 170 180 190 200
SSDPIALGVL QDKDLFSVFA DPNMLDTLVP AHPALVNAIV LVLHSVAGSA
210 220 230 240 250
PMPGTDSSSR SMPSSSYRDM PGGFLFEGLS DDEDDFHPNT RSTPSSSTPS
260 270 280 290 300
SRPASLGYSG AAGPRPITQS ELATALALAS TPESSSHTPT PGTQGHSSGT
310 320 330 340 350
SPMSSGVQSG TPITNDLFSQ ALQHALQASG QPSLQSQWQP QLQQLRDMGI
360 370 380
QDDELSLRAL QATGGDIQAA LELIFAGGAP
Length:380
Mass (Da):40,510
Last modified:March 29, 2004 - v2
Checksum:i0B64DF79597E0931
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti262A → V in AAK67643 (PubMed:12644319).Curated1
Sequence conflicti272L → R in AAK67643 (PubMed:12644319).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037166 mRNA. Translation: AAK67643.1.
CH471136 Genomic DNA. Translation: EAW99332.1.
CH471136 Genomic DNA. Translation: EAW99335.1.
CH471136 Genomic DNA. Translation: EAW99339.1.
BC007913 mRNA. Translation: AAH07913.1.
BC030055 mRNA. Translation: AAH30055.1.
BC033919 mRNA. Translation: AAH33919.1.
CCDSiCCDS10263.1.
RefSeqiNP_001273668.1. NM_001286739.1.
NP_001273669.1. NM_001286740.1.
NP_001273670.1. NM_001286741.1.
NP_001273671.1. NM_001286742.1.
NP_116296.1. NM_032907.4.
NP_957717.1. NM_201265.1.
UniGeneiHs.334713.

Genome annotation databases

EnsembliENST00000361351; ENSP00000354883; ENSG00000138629.
ENST00000395081; ENSP00000378518; ENSG00000138629.
ENST00000564488; ENSP00000454828; ENSG00000138629.
ENST00000565335; ENSP00000457708; ENSG00000138629.
ENST00000567435; ENSP00000457703; ENSG00000138629.
GeneIDi84993.
KEGGihsa:84993.
UCSCiuc002axw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037166 mRNA. Translation: AAK67643.1.
CH471136 Genomic DNA. Translation: EAW99332.1.
CH471136 Genomic DNA. Translation: EAW99335.1.
CH471136 Genomic DNA. Translation: EAW99339.1.
BC007913 mRNA. Translation: AAH07913.1.
BC030055 mRNA. Translation: AAH30055.1.
BC033919 mRNA. Translation: AAH33919.1.
CCDSiCCDS10263.1.
RefSeqiNP_001273668.1. NM_001286739.1.
NP_001273669.1. NM_001286740.1.
NP_001273670.1. NM_001286741.1.
NP_001273671.1. NM_001286742.1.
NP_116296.1. NM_032907.4.
NP_957717.1. NM_201265.1.
UniGeneiHs.334713.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CWBNMR-A336-380[»]
2DENNMR-A336-380[»]
ProteinModelPortaliQ96S82.
SMRiQ96S82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124418. 44 interactors.
IntActiQ96S82. 10 interactors.
MINTiMINT-1034167.
STRINGi9606.ENSP00000354883.

PTM databases

iPTMnetiQ96S82.
PhosphoSitePlusiQ96S82.

Polymorphism and mutation databases

BioMutaiUBL7.
DMDMi48474599.

Proteomic databases

EPDiQ96S82.
MaxQBiQ96S82.
PaxDbiQ96S82.
PeptideAtlasiQ96S82.
PRIDEiQ96S82.

Protocols and materials databases

DNASUi84993.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361351; ENSP00000354883; ENSG00000138629.
ENST00000395081; ENSP00000378518; ENSG00000138629.
ENST00000564488; ENSP00000454828; ENSG00000138629.
ENST00000565335; ENSP00000457708; ENSG00000138629.
ENST00000567435; ENSP00000457703; ENSG00000138629.
GeneIDi84993.
KEGGihsa:84993.
UCSCiuc002axw.3. human.

Organism-specific databases

CTDi84993.
DisGeNETi84993.
GeneCardsiUBL7.
HGNCiHGNC:28221. UBL7.
HPAiHPA040423.
HPA041897.
MIMi609748. gene.
neXtProtiNX_Q96S82.
OpenTargetsiENSG00000138629.
PharmGKBiPA142670645.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISS5. Eukaryota.
ENOG410YUJQ. LUCA.
GeneTreeiENSGT00390000015967.
HOVERGENiHBG054051.
InParanoidiQ96S82.
OMAiDDFHPSA.
OrthoDBiEOG091G0II5.
PhylomeDBiQ96S82.
TreeFamiTF327176.

Miscellaneous databases

ChiTaRSiUBL7. human.
EvolutionaryTraceiQ96S82.
GenomeRNAii84993.
PROiQ96S82.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138629.
CleanExiHS_UBL7.
ExpressionAtlasiQ96S82. baseline and differential.
GenevisibleiQ96S82. HS.

Family and domain databases

InterProiIPR015940. UBA.
IPR009060. UBA-like.
IPR015496. Ubiquilin.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10677. PTHR10677. 1 hit.
PfamiPF00627. UBA. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00165. UBA. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50030. UBA. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBL7_HUMAN
AccessioniPrimary (citable) accession number: Q96S82
Secondary accession number(s): D3DW57, Q96I03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.