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Protein

Ras-like protein family member 10B

Gene

RASL10B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18GTPBy similarity8
Nucleotide bindingi59 – 62GTPBy similarity4
Nucleotide bindingi128 – 131GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141150-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein family member 10B
Alternative name(s):
Ras-like protein VTS58635
Ras-related protein 17
Short name:
RRP17
Gene namesi
Name:RASL10B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30295. RASL10B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi91608.
OpenTargetsiENSG00000270885.
PharmGKBiPA134936888.

Polymorphism and mutation databases

BioMutaiRASL10B.
DMDMi74732702.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002808001 – 200Ras-like protein family member 10BAdd BLAST200
PropeptideiPRO_0000281362201 – 203Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei200Cysteine methyl esterBy similarity1
Lipidationi200S-geranylgeranyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ96S79.
PeptideAtlasiQ96S79.
PRIDEiQ96S79.

PTM databases

iPTMnetiQ96S79.
PhosphoSitePlusiQ96S79.

Expressioni

Tissue specificityi

Expressed at high levels in skeletal muscle and, at much lower levels, in heart, brain and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000141150.
CleanExiHS_RASL10B.
GenevisibleiQ96S79. HS.

Organism-specific databases

HPAiHPA046842.
HPA057092.

Interactioni

Subunit structurei

Interacts with CADPS.By similarity

Protein-protein interaction databases

BioGridi124852. 26 interactors.
IntActiQ96S79. 9 interactors.
STRINGi9606.ENSP00000268864.

Structurei

3D structure databases

ProteinModelPortaliQ96S79.
SMRiQ96S79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 203Small GTPase-likeAdd BLAST203

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 42Effector region10

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133830.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ96S79.
KOiK07851.
OMAiVNSLYEW.
OrthoDBiEOG091G0JOZ.
PhylomeDBiQ96S79.
TreeFamiTF325043.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96S79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSTYRVAVL GARGVGKSAI VRQFLYNEFS EVCVPTTARR LYLPAVVMNG
60 70 80 90 100
HVHDLQILDF PPISAFPVNT LQEWADTCCR GLRSVHAYIL VYDICCFDSF
110 120 130 140 150
EYVKTIRQQI LETRVIGTSE TPIIIVGNKR DLQRGRVIPR WNVSHLVRKT
160 170 180 190 200
WKCGYVECSA KYNWHILLLF SELLKSVGCA RCKHVHAALR FQGALRRNRC

AIM
Length:203
Mass (Da):23,229
Last modified:December 1, 2001 - v1
Checksum:iA9771A883B30A8BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109Q → R in BAG53643 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03630952V → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs781851443dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047296 mRNA. Translation: BAB60894.1.
AK122652 mRNA. Translation: BAG53643.1.
BC041133 mRNA. Translation: AAH41133.1.
CCDSiCCDS11297.1.
RefSeqiNP_201572.1. NM_033315.3.
XP_016880790.1. XM_017025301.1.
UniGeneiHs.744994.

Genome annotation databases

EnsembliENST00000603017; ENSP00000474230; ENSG00000270885.
GeneIDi91608.
KEGGihsa:91608.
UCSCiuc002hju.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047296 mRNA. Translation: BAB60894.1.
AK122652 mRNA. Translation: BAG53643.1.
BC041133 mRNA. Translation: AAH41133.1.
CCDSiCCDS11297.1.
RefSeqiNP_201572.1. NM_033315.3.
XP_016880790.1. XM_017025301.1.
UniGeneiHs.744994.

3D structure databases

ProteinModelPortaliQ96S79.
SMRiQ96S79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124852. 26 interactors.
IntActiQ96S79. 9 interactors.
STRINGi9606.ENSP00000268864.

PTM databases

iPTMnetiQ96S79.
PhosphoSitePlusiQ96S79.

Polymorphism and mutation databases

BioMutaiRASL10B.
DMDMi74732702.

Proteomic databases

PaxDbiQ96S79.
PeptideAtlasiQ96S79.
PRIDEiQ96S79.

Protocols and materials databases

DNASUi91608.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000603017; ENSP00000474230; ENSG00000270885.
GeneIDi91608.
KEGGihsa:91608.
UCSCiuc002hju.4. human.

Organism-specific databases

CTDi91608.
DisGeNETi91608.
GeneCardsiRASL10B.
HGNCiHGNC:30295. RASL10B.
HPAiHPA046842.
HPA057092.
MIMi612128. gene.
neXtProtiNX_Q96S79.
OpenTargetsiENSG00000270885.
PharmGKBiPA134936888.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133830.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ96S79.
KOiK07851.
OMAiVNSLYEW.
OrthoDBiEOG091G0JOZ.
PhylomeDBiQ96S79.
TreeFamiTF325043.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141150-MONOMER.

Miscellaneous databases

GenomeRNAii91608.
PROiQ96S79.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141150.
CleanExiHS_RASL10B.
GenevisibleiQ96S79. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRSLAB_HUMAN
AccessioniPrimary (citable) accession number: Q96S79
Secondary accession number(s): B3KV31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.