Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-like protein family member 10B

Gene

RASL10B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18GTPBy similarity8
Nucleotide bindingi59 – 62GTPBy similarity4
Nucleotide bindingi128 – 131GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein family member 10B
Alternative name(s):
Ras-like protein VTS58635
Ras-related protein 17
Short name:
RRP17
Gene namesi
Name:RASL10B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000270885.1
HGNCiHGNC:30295 RASL10B
MIMi612128 gene
neXtProtiNX_Q96S79

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi91608
OpenTargetsiENSG00000270885
PharmGKBiPA134936888

Polymorphism and mutation databases

BioMutaiRASL10B
DMDMi74732702

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002808001 – 200Ras-like protein family member 10BAdd BLAST200
PropeptideiPRO_0000281362201 – 203Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei200Cysteine methyl esterBy similarity1
Lipidationi200S-geranylgeranyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ96S79
PeptideAtlasiQ96S79
PRIDEiQ96S79

PTM databases

iPTMnetiQ96S79
PhosphoSitePlusiQ96S79

Expressioni

Tissue specificityi

Expressed at high levels in skeletal muscle and, at much lower levels, in heart, brain and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000270885
CleanExiHS_RASL10B
GenevisibleiQ96S79 HS

Organism-specific databases

HPAiHPA046842
HPA057092

Interactioni

Subunit structurei

Interacts with CADPS.By similarity

Protein-protein interaction databases

BioGridi12485227 interactors.
IntActiQ96S79 9 interactors.
MINTiQ96S79
STRINGi9606.ENSP00000268864

Structurei

3D structure databases

ProteinModelPortaliQ96S79
SMRiQ96S79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 203Small GTPase-likeAdd BLAST203

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 42Effector region10

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ96S79
KOiK07851
OMAiVVGNKHD
OrthoDBiEOG091G0JOZ
PhylomeDBiQ96S79
TreeFamiTF325043

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96S79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSTYRVAVL GARGVGKSAI VRQFLYNEFS EVCVPTTARR LYLPAVVMNG
60 70 80 90 100
HVHDLQILDF PPISAFPVNT LQEWADTCCR GLRSVHAYIL VYDICCFDSF
110 120 130 140 150
EYVKTIRQQI LETRVIGTSE TPIIIVGNKR DLQRGRVIPR WNVSHLVRKT
160 170 180 190 200
WKCGYVECSA KYNWHILLLF SELLKSVGCA RCKHVHAALR FQGALRRNRC

AIM
Length:203
Mass (Da):23,229
Last modified:December 1, 2001 - v1
Checksum:iA9771A883B30A8BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109Q → R in BAG53643 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03630952V → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs781851443Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047296 mRNA Translation: BAB60894.1
AK122652 mRNA Translation: BAG53643.1
BC041133 mRNA Translation: AAH41133.1
CCDSiCCDS11297.1
RefSeqiNP_201572.1, NM_033315.3
XP_016880790.1, XM_017025301.1
UniGeneiHs.744994

Genome annotation databases

EnsembliENST00000603017; ENSP00000474230; ENSG00000270885
GeneIDi91608
KEGGihsa:91608
UCSCiuc002hju.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRSLAB_HUMAN
AccessioniPrimary (citable) accession number: Q96S79
Secondary accession number(s): B3KV31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome