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Q96S66 (CLCC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chloride channel CLIC-like protein 1
Alternative name(s):
Mid-1-related chloride channel protein 1
Gene names
Name:CLCC1
Synonyms:KIAA0761, MCLC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to act as a chloride ion channel By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential. Endoplasmic reticulum. Golgi apparatus. Nucleus By similarity.

Sequence similarities

Belongs to the chloride channel MCLC family.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96S66-1)

Also known as: hMCLC-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96S66-2)

Also known as: hMCLC-2;

The sequence of this isoform differs from the canonical sequence as follows:
     114-163: Missing.
Isoform 3 (identifier: Q96S66-3)

Also known as: hMCLC-3;

The sequence of this isoform differs from the canonical sequence as follows:
     114-234: Missing.
Isoform 4 (identifier: Q96S66-4)

Also known as: hMCLC-4;

The sequence of this isoform differs from the canonical sequence as follows:
     114-298: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 551533Chloride channel CLIC-like protein 1
PRO_0000297682

Regions

Transmembrane185 – 20521Helical; Potential
Transmembrane217 – 23721Helical; Potential
Transmembrane330 – 35021Helical; Potential

Amino acid modifications

Modified residue4381Phosphoserine Ref.6 Ref.7 Ref.8
Modified residue4641Phosphoserine Ref.8
Modified residue4821Phosphothreonine Ref.10
Modified residue5091Phosphoserine Ref.8 Ref.12
Modified residue5241Phosphoserine Ref.8 Ref.10
Modified residue5321Phosphoserine Ref.8 Ref.10

Natural variations

Alternative sequence114 – 298185Missing in isoform 4.
VSP_027347
Alternative sequence114 – 234121Missing in isoform 3.
VSP_027348
Alternative sequence114 – 16350Missing in isoform 2.
VSP_027349
Natural variant3681S → R.
Corresponds to variant rs168107 [ dbSNP | Ensembl ].
VAR_034673

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (hMCLC-1) [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 08709A80E99F2E15

FASTA55162,023
        10         20         30         40         50         60 
MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG EKDVSPDLSC 

        70         80         90        100        110        120 
ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY LNKILIEAGK LGLPDENKGD 

       130        140        150        160        170        180 
MHYDAEIILK RETLLEIQKF LNGEDWKPGA LDDALSDILI NFKFHDFETW KWRFEDSFGV 

       190        200        210        220        230        240 
DPYNVLMVLL CLLCIVVLVA TELWTYVRWY TQLRRVLIIS FLFSLGWNWM YLYKLAFAQH 

       250        260        270        280        290        300 
QAEVAKMEPL NNVCAKKMDW TGSIWEWFRS SWTYKDDPCQ KYYELLLVNP IWLVPPTKAL 

       310        320        330        340        350        360 
AVTFTTFVTE PLKHIGKGTG EFIKALMKEI PALLHLPVLI IMALAILSFC YGAGKSVHVL 

       370        380        390        400        410        420 
RHIGGPESEP PQALRPRDRR RQEEIDYRPD GGAGDADFHY RGQMGPTEQG PYAKTYEGRR 

       430        440        450        460        470        480 
EILRERDVDL RFQTGNKSPE VLRAFDVPDA EAREHPTVVP SHKSPVLDTK PKETGGILGE 

       490        500        510        520        530        540 
GTPKESSTES SQSAKPVSGQ DTSGNTEGSP AAEKAQLKSE AAGSPDQGST YSPARGVAGP 

       550 
RGQDPVSSPC G 

« Hide

Isoform 2 (hMCLC-2) [UniParc].

Checksum: 2AAB4D99DA5EB327
Show »

FASTA50156,267
Isoform 3 (hMCLC-3) [UniParc].

Checksum: DB73E1B97B4B9660
Show »

FASTA43047,437
Isoform 4 (hMCLC-4) [UniParc].

Checksum: 6214C106333DBAEC
Show »

FASTA36639,838

References

« Hide 'large scale' references
[1]"Identification of a novel chloride channel expressed in the endoplasmic reticulum, Golgi apparatus, and nucleus."
Nagasawa M., Kanzaki M., Iino Y., Morishita Y., Kojima I.
J. Biol. Chem. 276:20413-20418(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
[2]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Skin.
[6]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438; SER-464; SER-509; SER-524 AND SER-532, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-482; SER-524 AND SER-532, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB052915 mRNA. Translation: BAB59018.1.
AB052916 mRNA. Translation: BAB79261.1.
AB052917 mRNA. Translation: BAB79262.1.
AB052918 mRNA. Translation: BAB79263.1.
AB018304 mRNA. Translation: BAA34481.2.
AL449266 Genomic DNA. Translation: CAI14363.1.
AL449266 Genomic DNA. Translation: CAI14364.1.
AL449266 Genomic DNA. Translation: CAI14365.1.
AL449266 Genomic DNA. Translation: CAI14366.1.
CH471122 Genomic DNA. Translation: EAW56345.1.
CH471122 Genomic DNA. Translation: EAW56346.1.
BC002939 mRNA. Translation: AAH02939.1.
RefSeqNP_001041675.1. NM_001048210.2.
NP_001265131.1. NM_001278202.1.
NP_001265132.1. NM_001278203.1.
NP_055942.1. NM_015127.4.
XP_005270719.1. XM_005270662.1.
XP_005270720.1. XM_005270663.1.
XP_005270721.1. XM_005270664.1.
UniGeneHs.658489.

3D structure databases

ProteinModelPortalQ96S66.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116769. 2 interactions.
IntActQ96S66. 2 interactions.
STRING9606.ENSP00000349456.

Protein family/group databases

TCDB1.A.36.1.1. the intracellular chloride channel (icc) family.

PTM databases

PhosphoSiteQ96S66.

Polymorphism databases

DMDM74752121.

Proteomic databases

PaxDbQ96S66.
PRIDEQ96S66.

Protocols and materials databases

DNASU23155.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302500; ENSP00000306552; ENSG00000121940. [Q96S66-3]
ENST00000348264; ENSP00000337243; ENSG00000121940. [Q96S66-4]
ENST00000356970; ENSP00000349456; ENSG00000121940. [Q96S66-1]
ENST00000369968; ENSP00000358985; ENSG00000121940. [Q96S66-4]
ENST00000369969; ENSP00000358986; ENSG00000121940. [Q96S66-3]
ENST00000369970; ENSP00000358987; ENSG00000121940. [Q96S66-2]
ENST00000369971; ENSP00000358988; ENSG00000121940. [Q96S66-1]
ENST00000415331; ENSP00000411591; ENSG00000121940. [Q96S66-2]
GeneID23155.
KEGGhsa:23155.
UCSCuc001dwf.2. human. [Q96S66-1]
uc001dwg.2. human. [Q96S66-2]
uc009wes.2. human. [Q96S66-3]
uc009wet.2. human. [Q96S66-4]

Organism-specific databases

CTD23155.
GeneCardsGC01M109472.
HGNCHGNC:29675. CLCC1.
HPAHPA009087.
HPA013210.
neXtProtNX_Q96S66.
PharmGKBPA142672105.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44384.
HOGENOMHOG000231351.
HOVERGENHBG060364.
InParanoidQ96S66.
OMASWTYKDD.
OrthoDBEOG7B8S3V.
PhylomeDBQ96S66.
TreeFamTF328890.

Gene expression databases

ArrayExpressQ96S66.
BgeeQ96S66.
CleanExHS_CLCC1.
GenevestigatorQ96S66.

Family and domain databases

InterProIPR009231. Chloride_chnl_CLIC-like.
[Graphical view]
PfamPF05934. MCLC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCLCC1.
GenomeRNAi23155.
NextBio44493.
PROQ96S66.

Entry information

Entry nameCLCC1_HUMAN
AccessionPrimary (citable) accession number: Q96S66
Secondary accession number(s): O94861 expand/collapse secondary AC list , Q8WYP8, Q8WYP9, Q9BU25
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 1, 2001
Last modified: March 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM