UniProtKB - Q96S66 (CLCC1_HUMAN)
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Protein
Chloride channel CLIC-like protein 1
Gene
CLCC1
Organism
Homo sapiens (Human)
Status
Functioni
Seems to act as a chloride ion channel.By similarity
GO - Molecular functioni
- chloride channel activity Source: UniProtKB-KW
Keywordsi
Molecular function | Chloride channel, Ion channel |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Protein family/group databases
TCDBi | 1.A.36.1.1 the intracellular chloride channel (icc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Chloride channel CLIC-like protein 1Alternative name(s): Mid-1-related chloride channel protein 1 |
Gene namesi | Name:CLCC1 Synonyms:KIAA0761, MCLC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000121940.15 |
HGNCi | HGNC:29675 CLCC1 |
MIMi | 617539 gene |
neXtProti | NX_Q96S66 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 185 – 205 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 217 – 237 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 330 – 350 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 23155 |
OpenTargetsi | ENSG00000121940 |
PharmGKBi | PA142672105 |
Polymorphism and mutation databases
DMDMi | 74752121 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000297682 | 19 – 551 | Chloride channel CLIC-like protein 1Add BLAST | 533 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 438 | PhosphoserineCombined sources | 1 | |
Modified residuei | 464 | PhosphoserineCombined sources | 1 | |
Modified residuei | 482 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 509 | PhosphoserineCombined sources | 1 | |
Modified residuei | 524 | PhosphoserineCombined sources | 1 | |
Modified residuei | 532 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96S66 |
MaxQBi | Q96S66 |
PaxDbi | Q96S66 |
PeptideAtlasi | Q96S66 |
PRIDEi | Q96S66 |
PTM databases
iPTMneti | Q96S66 |
PhosphoSitePlusi | Q96S66 |
SwissPalmi | Q96S66 |
Expressioni
Gene expression databases
Bgeei | ENSG00000121940 |
CleanExi | HS_CLCC1 |
ExpressionAtlasi | Q96S66 baseline and differential |
Genevisiblei | Q96S66 HS |
Organism-specific databases
HPAi | HPA009087 HPA013210 |
Interactioni
Protein-protein interaction databases
BioGridi | 11676933 interactors. |
IntActi | Q96S66 11 interactors. |
MINTi | Q96S66 |
STRINGi | 9606.ENSP00000349456 |
Family & Domainsi
Sequence similaritiesi
Belongs to the chloride channel MCLC family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IJAP Eukaryota ENOG41108E0 LUCA |
GeneTreei | ENSGT00390000016611 |
HOGENOMi | HOG000231351 |
HOVERGENi | HBG060364 |
InParanoidi | Q96S66 |
KOi | K22188 |
OMAi | NWMYLYK |
OrthoDBi | EOG091G0BRS |
PhylomeDBi | Q96S66 |
TreeFami | TF328890 |
Family and domain databases
InterProi | View protein in InterPro IPR009231 Chloride_chnl_CLIC-like |
PANTHERi | PTHR34093 PTHR34093, 1 hit |
Pfami | View protein in Pfam PF05934 MCLC, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96S66-1) [UniParc]FASTAAdd to basket
Also known as: hMCLC-1
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG
60 70 80 90 100
EKDVSPDLSC ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY
110 120 130 140 150
LNKILIEAGK LGLPDENKGD MHYDAEIILK RETLLEIQKF LNGEDWKPGA
160 170 180 190 200
LDDALSDILI NFKFHDFETW KWRFEDSFGV DPYNVLMVLL CLLCIVVLVA
210 220 230 240 250
TELWTYVRWY TQLRRVLIIS FLFSLGWNWM YLYKLAFAQH QAEVAKMEPL
260 270 280 290 300
NNVCAKKMDW TGSIWEWFRS SWTYKDDPCQ KYYELLLVNP IWLVPPTKAL
310 320 330 340 350
AVTFTTFVTE PLKHIGKGTG EFIKALMKEI PALLHLPVLI IMALAILSFC
360 370 380 390 400
YGAGKSVHVL RHIGGPESEP PQALRPRDRR RQEEIDYRPD GGAGDADFHY
410 420 430 440 450
RGQMGPTEQG PYAKTYEGRR EILRERDVDL RFQTGNKSPE VLRAFDVPDA
460 470 480 490 500
EAREHPTVVP SHKSPVLDTK PKETGGILGE GTPKESSTES SQSAKPVSGQ
510 520 530 540 550
DTSGNTEGSP AAEKAQLKSE AAGSPDQGST YSPARGVAGP RGQDPVSSPC
G
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034673 | 368 | S → R. Corresponds to variant dbSNP:rs168107Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027347 | 114 – 298 | Missing in isoform 4. 1 PublicationAdd BLAST | 185 | |
Alternative sequenceiVSP_027348 | 114 – 234 | Missing in isoform 3. 1 PublicationAdd BLAST | 121 | |
Alternative sequenceiVSP_027349 | 114 – 163 | Missing in isoform 2. 2 PublicationsAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB052915 mRNA Translation: BAB59018.1 AB052916 mRNA Translation: BAB79261.1 AB052917 mRNA Translation: BAB79262.1 AB052918 mRNA Translation: BAB79263.1 AB018304 mRNA Translation: BAA34481.2 AL449266 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56345.1 CH471122 Genomic DNA Translation: EAW56346.1 BC002939 mRNA Translation: AAH02939.1 |
CCDSi | CCDS41362.1 [Q96S66-1] CCDS60214.1 [Q96S66-4] CCDS60215.1 [Q96S66-3] CCDS793.1 [Q96S66-2] |
RefSeqi | NP_001041675.1, NM_001048210.2 [Q96S66-1] NP_001265131.1, NM_001278202.1 [Q96S66-3] NP_001265132.1, NM_001278203.1 [Q96S66-4] NP_055942.1, NM_015127.4 [Q96S66-2] |
UniGenei | Hs.658489 |
Genome annotation databases
Ensembli | ENST00000302500; ENSP00000306552; ENSG00000121940 [Q96S66-3] ENST00000348264; ENSP00000337243; ENSG00000121940 [Q96S66-4] ENST00000356970; ENSP00000349456; ENSG00000121940 [Q96S66-1] ENST00000369968; ENSP00000358985; ENSG00000121940 [Q96S66-4] ENST00000369969; ENSP00000358986; ENSG00000121940 [Q96S66-3] ENST00000369970; ENSP00000358987; ENSG00000121940 [Q96S66-2] |
GeneIDi | 23155 |
KEGGi | hsa:23155 |
UCSCi | uc009wes.2 human [Q96S66-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | CLCC1_HUMAN | |
Accessioni | Q96S66Primary (citable) accession number: Q96S66 Secondary accession number(s): O94861 Q9BU25 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 28, 2018 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |