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Protein

Chloride channel CLIC-like protein 1

Gene

CLCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to act as a chloride ion channel.By similarity

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Protein family/group databases

TCDBi1.A.36.1.1. the intracellular chloride channel (icc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel CLIC-like protein 1
Alternative name(s):
Mid-1-related chloride channel protein 1
Gene namesi
Name:CLCC1
Synonyms:KIAA0761, MCLC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29675. CLCC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei185 – 20521HelicalSequence AnalysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence AnalysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. chloride channel complex Source: UniProtKB-KW
  2. endoplasmic reticulum Source: HPA
  3. Golgi apparatus Source: UniProtKB-SubCell
  4. intracellular membrane-bounded organelle Source: HPA
  5. membrane Source: UniProtKB
  6. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 551533Chloride channel CLIC-like protein 1PRO_0000297682Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei438 – 4381Phosphoserine4 Publications
Modified residuei464 – 4641Phosphoserine1 Publication
Modified residuei482 – 4821Phosphothreonine1 Publication
Modified residuei509 – 5091Phosphoserine2 Publications
Modified residuei524 – 5241Phosphoserine2 Publications
Modified residuei532 – 5321Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96S66.
PaxDbiQ96S66.
PRIDEiQ96S66.

PTM databases

PhosphoSiteiQ96S66.

Expressioni

Gene expression databases

BgeeiQ96S66.
CleanExiHS_CLCC1.
ExpressionAtlasiQ96S66. baseline and differential.
GenevestigatoriQ96S66.

Organism-specific databases

HPAiHPA009087.
HPA013210.

Interactioni

Protein-protein interaction databases

BioGridi116769. 8 interactions.
IntActiQ96S66. 2 interactions.
STRINGi9606.ENSP00000349456.

Structurei

3D structure databases

ProteinModelPortaliQ96S66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chloride channel MCLC family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44384.
GeneTreeiENSGT00390000016611.
HOGENOMiHOG000231351.
HOVERGENiHBG060364.
InParanoidiQ96S66.
OMAiSWTYKDD.
OrthoDBiEOG7B8S3V.
PhylomeDBiQ96S66.
TreeFamiTF328890.

Family and domain databases

InterProiIPR009231. Chloride_chnl_CLIC-like.
[Graphical view]
PfamiPF05934. MCLC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96S66-1) [UniParc]FASTAAdd to basket

Also known as: hMCLC-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG
60 70 80 90 100
EKDVSPDLSC ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY
110 120 130 140 150
LNKILIEAGK LGLPDENKGD MHYDAEIILK RETLLEIQKF LNGEDWKPGA
160 170 180 190 200
LDDALSDILI NFKFHDFETW KWRFEDSFGV DPYNVLMVLL CLLCIVVLVA
210 220 230 240 250
TELWTYVRWY TQLRRVLIIS FLFSLGWNWM YLYKLAFAQH QAEVAKMEPL
260 270 280 290 300
NNVCAKKMDW TGSIWEWFRS SWTYKDDPCQ KYYELLLVNP IWLVPPTKAL
310 320 330 340 350
AVTFTTFVTE PLKHIGKGTG EFIKALMKEI PALLHLPVLI IMALAILSFC
360 370 380 390 400
YGAGKSVHVL RHIGGPESEP PQALRPRDRR RQEEIDYRPD GGAGDADFHY
410 420 430 440 450
RGQMGPTEQG PYAKTYEGRR EILRERDVDL RFQTGNKSPE VLRAFDVPDA
460 470 480 490 500
EAREHPTVVP SHKSPVLDTK PKETGGILGE GTPKESSTES SQSAKPVSGQ
510 520 530 540 550
DTSGNTEGSP AAEKAQLKSE AAGSPDQGST YSPARGVAGP RGQDPVSSPC

G
Length:551
Mass (Da):62,023
Last modified:December 1, 2001 - v1
Checksum:i08709A80E99F2E15
GO
Isoform 2 (identifier: Q96S66-2) [UniParc]FASTAAdd to basket

Also known as: hMCLC-2

The sequence of this isoform differs from the canonical sequence as follows:
     114-163: Missing.

Show »
Length:501
Mass (Da):56,267
Checksum:i2AAB4D99DA5EB327
GO
Isoform 3 (identifier: Q96S66-3) [UniParc]FASTAAdd to basket

Also known as: hMCLC-3

The sequence of this isoform differs from the canonical sequence as follows:
     114-234: Missing.

Show »
Length:430
Mass (Da):47,437
Checksum:iDB73E1B97B4B9660
GO
Isoform 4 (identifier: Q96S66-4) [UniParc]FASTAAdd to basket

Also known as: hMCLC-4

The sequence of this isoform differs from the canonical sequence as follows:
     114-298: Missing.

Show »
Length:366
Mass (Da):39,838
Checksum:i6214C106333DBAEC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti368 – 3681S → R.
Corresponds to variant rs168107 [ dbSNP | Ensembl ].
VAR_034673

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei114 – 298185Missing in isoform 4. 1 PublicationVSP_027347Add
BLAST
Alternative sequencei114 – 234121Missing in isoform 3. 1 PublicationVSP_027348Add
BLAST
Alternative sequencei114 – 16350Missing in isoform 2. 2 PublicationsVSP_027349Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052915 mRNA. Translation: BAB59018.1.
AB052916 mRNA. Translation: BAB79261.1.
AB052917 mRNA. Translation: BAB79262.1.
AB052918 mRNA. Translation: BAB79263.1.
AB018304 mRNA. Translation: BAA34481.2.
AL449266 Genomic DNA. Translation: CAI14363.1.
AL449266 Genomic DNA. Translation: CAI14364.1.
AL449266 Genomic DNA. Translation: CAI14365.1.
AL449266 Genomic DNA. Translation: CAI14366.1.
CH471122 Genomic DNA. Translation: EAW56345.1.
CH471122 Genomic DNA. Translation: EAW56346.1.
BC002939 mRNA. Translation: AAH02939.1.
CCDSiCCDS41362.1. [Q96S66-1]
CCDS60214.1. [Q96S66-4]
CCDS60215.1. [Q96S66-3]
CCDS793.1. [Q96S66-2]
RefSeqiNP_001041675.1. NM_001048210.2. [Q96S66-1]
NP_001265131.1. NM_001278202.1. [Q96S66-3]
NP_001265132.1. NM_001278203.1. [Q96S66-4]
NP_055942.1. NM_015127.4. [Q96S66-2]
UniGeneiHs.658489.

Genome annotation databases

EnsembliENST00000302500; ENSP00000306552; ENSG00000121940. [Q96S66-3]
ENST00000348264; ENSP00000337243; ENSG00000121940. [Q96S66-4]
ENST00000356970; ENSP00000349456; ENSG00000121940. [Q96S66-1]
ENST00000369968; ENSP00000358985; ENSG00000121940. [Q96S66-4]
ENST00000369969; ENSP00000358986; ENSG00000121940. [Q96S66-3]
ENST00000369970; ENSP00000358987; ENSG00000121940. [Q96S66-2]
GeneIDi23155.
KEGGihsa:23155.
UCSCiuc001dwf.2. human. [Q96S66-1]
uc001dwg.2. human. [Q96S66-2]
uc009wes.2. human. [Q96S66-3]
uc009wet.2. human. [Q96S66-4]

Polymorphism databases

DMDMi74752121.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052915 mRNA. Translation: BAB59018.1.
AB052916 mRNA. Translation: BAB79261.1.
AB052917 mRNA. Translation: BAB79262.1.
AB052918 mRNA. Translation: BAB79263.1.
AB018304 mRNA. Translation: BAA34481.2.
AL449266 Genomic DNA. Translation: CAI14363.1.
AL449266 Genomic DNA. Translation: CAI14364.1.
AL449266 Genomic DNA. Translation: CAI14365.1.
AL449266 Genomic DNA. Translation: CAI14366.1.
CH471122 Genomic DNA. Translation: EAW56345.1.
CH471122 Genomic DNA. Translation: EAW56346.1.
BC002939 mRNA. Translation: AAH02939.1.
CCDSiCCDS41362.1. [Q96S66-1]
CCDS60214.1. [Q96S66-4]
CCDS60215.1. [Q96S66-3]
CCDS793.1. [Q96S66-2]
RefSeqiNP_001041675.1. NM_001048210.2. [Q96S66-1]
NP_001265131.1. NM_001278202.1. [Q96S66-3]
NP_001265132.1. NM_001278203.1. [Q96S66-4]
NP_055942.1. NM_015127.4. [Q96S66-2]
UniGeneiHs.658489.

3D structure databases

ProteinModelPortaliQ96S66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116769. 8 interactions.
IntActiQ96S66. 2 interactions.
STRINGi9606.ENSP00000349456.

Protein family/group databases

TCDBi1.A.36.1.1. the intracellular chloride channel (icc) family.

PTM databases

PhosphoSiteiQ96S66.

Polymorphism databases

DMDMi74752121.

Proteomic databases

MaxQBiQ96S66.
PaxDbiQ96S66.
PRIDEiQ96S66.

Protocols and materials databases

DNASUi23155.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302500; ENSP00000306552; ENSG00000121940. [Q96S66-3]
ENST00000348264; ENSP00000337243; ENSG00000121940. [Q96S66-4]
ENST00000356970; ENSP00000349456; ENSG00000121940. [Q96S66-1]
ENST00000369968; ENSP00000358985; ENSG00000121940. [Q96S66-4]
ENST00000369969; ENSP00000358986; ENSG00000121940. [Q96S66-3]
ENST00000369970; ENSP00000358987; ENSG00000121940. [Q96S66-2]
GeneIDi23155.
KEGGihsa:23155.
UCSCiuc001dwf.2. human. [Q96S66-1]
uc001dwg.2. human. [Q96S66-2]
uc009wes.2. human. [Q96S66-3]
uc009wet.2. human. [Q96S66-4]

Organism-specific databases

CTDi23155.
GeneCardsiGC01M109472.
HGNCiHGNC:29675. CLCC1.
HPAiHPA009087.
HPA013210.
neXtProtiNX_Q96S66.
PharmGKBiPA142672105.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44384.
GeneTreeiENSGT00390000016611.
HOGENOMiHOG000231351.
HOVERGENiHBG060364.
InParanoidiQ96S66.
OMAiSWTYKDD.
OrthoDBiEOG7B8S3V.
PhylomeDBiQ96S66.
TreeFamiTF328890.

Miscellaneous databases

GeneWikiiCLCC1.
GenomeRNAii23155.
NextBioi44493.
PROiQ96S66.

Gene expression databases

BgeeiQ96S66.
CleanExiHS_CLCC1.
ExpressionAtlasiQ96S66. baseline and differential.
GenevestigatoriQ96S66.

Family and domain databases

InterProiIPR009231. Chloride_chnl_CLIC-like.
[Graphical view]
PfamiPF05934. MCLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel chloride channel expressed in the endoplasmic reticulum, Golgi apparatus, and nucleus."
    Nagasawa M., Kanzaki M., Iino Y., Morishita Y., Kojima I.
    J. Biol. Chem. 276:20413-20418(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
  2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
    Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
    J. Proteome Res. 6:4150-4162(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438; SER-464; SER-509; SER-524 AND SER-532, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-482; SER-524 AND SER-532, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCLCC1_HUMAN
AccessioniPrimary (citable) accession number: Q96S66
Secondary accession number(s): O94861
, Q8WYP8, Q8WYP9, Q9BU25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 1, 2001
Last modified: March 4, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.