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Q96S66

- CLCC1_HUMAN

UniProt

Q96S66 - CLCC1_HUMAN

Protein

Chloride channel CLIC-like protein 1

Gene

CLCC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Seems to act as a chloride ion channel.By similarity

    GO - Molecular functioni

    1. chloride channel activity Source: Ensembl

    Keywords - Molecular functioni

    Chloride channel, Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Protein family/group databases

    TCDBi1.A.36.1.1. the intracellular chloride channel (icc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chloride channel CLIC-like protein 1
    Alternative name(s):
    Mid-1-related chloride channel protein 1
    Gene namesi
    Name:CLCC1
    Synonyms:KIAA0761, MCLC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29675. CLCC1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: HPA
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. intracellular membrane-bounded organelle Source: HPA
    5. membrane Source: UniProtKB
    6. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672105.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 551533Chloride channel CLIC-like protein 1PRO_0000297682Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei438 – 4381Phosphoserine3 Publications
    Modified residuei464 – 4641Phosphoserine1 Publication
    Modified residuei482 – 4821Phosphothreonine1 Publication
    Modified residuei509 – 5091Phosphoserine2 Publications
    Modified residuei524 – 5241Phosphoserine2 Publications
    Modified residuei532 – 5321Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96S66.
    PaxDbiQ96S66.
    PRIDEiQ96S66.

    PTM databases

    PhosphoSiteiQ96S66.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96S66.
    BgeeiQ96S66.
    CleanExiHS_CLCC1.
    GenevestigatoriQ96S66.

    Organism-specific databases

    HPAiHPA009087.
    HPA013210.

    Interactioni

    Protein-protein interaction databases

    BioGridi116769. 2 interactions.
    IntActiQ96S66. 2 interactions.
    STRINGi9606.ENSP00000349456.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96S66.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei185 – 20521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei330 – 35021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chloride channel MCLC family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44384.
    HOGENOMiHOG000231351.
    HOVERGENiHBG060364.
    InParanoidiQ96S66.
    OMAiSWTYKDD.
    OrthoDBiEOG7B8S3V.
    PhylomeDBiQ96S66.
    TreeFamiTF328890.

    Family and domain databases

    InterProiIPR009231. Chloride_chnl_CLIC-like.
    [Graphical view]
    PfamiPF05934. MCLC. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96S66-1) [UniParc]FASTAAdd to Basket

    Also known as: hMCLC-1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG    50
    EKDVSPDLSC ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY 100
    LNKILIEAGK LGLPDENKGD MHYDAEIILK RETLLEIQKF LNGEDWKPGA 150
    LDDALSDILI NFKFHDFETW KWRFEDSFGV DPYNVLMVLL CLLCIVVLVA 200
    TELWTYVRWY TQLRRVLIIS FLFSLGWNWM YLYKLAFAQH QAEVAKMEPL 250
    NNVCAKKMDW TGSIWEWFRS SWTYKDDPCQ KYYELLLVNP IWLVPPTKAL 300
    AVTFTTFVTE PLKHIGKGTG EFIKALMKEI PALLHLPVLI IMALAILSFC 350
    YGAGKSVHVL RHIGGPESEP PQALRPRDRR RQEEIDYRPD GGAGDADFHY 400
    RGQMGPTEQG PYAKTYEGRR EILRERDVDL RFQTGNKSPE VLRAFDVPDA 450
    EAREHPTVVP SHKSPVLDTK PKETGGILGE GTPKESSTES SQSAKPVSGQ 500
    DTSGNTEGSP AAEKAQLKSE AAGSPDQGST YSPARGVAGP RGQDPVSSPC 550
    G 551
    Length:551
    Mass (Da):62,023
    Last modified:December 1, 2001 - v1
    Checksum:i08709A80E99F2E15
    GO
    Isoform 2 (identifier: Q96S66-2) [UniParc]FASTAAdd to Basket

    Also known as: hMCLC-2

    The sequence of this isoform differs from the canonical sequence as follows:
         114-163: Missing.

    Show »
    Length:501
    Mass (Da):56,267
    Checksum:i2AAB4D99DA5EB327
    GO
    Isoform 3 (identifier: Q96S66-3) [UniParc]FASTAAdd to Basket

    Also known as: hMCLC-3

    The sequence of this isoform differs from the canonical sequence as follows:
         114-234: Missing.

    Show »
    Length:430
    Mass (Da):47,437
    Checksum:iDB73E1B97B4B9660
    GO
    Isoform 4 (identifier: Q96S66-4) [UniParc]FASTAAdd to Basket

    Also known as: hMCLC-4

    The sequence of this isoform differs from the canonical sequence as follows:
         114-298: Missing.

    Show »
    Length:366
    Mass (Da):39,838
    Checksum:i6214C106333DBAEC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti368 – 3681S → R.
    Corresponds to variant rs168107 [ dbSNP | Ensembl ].
    VAR_034673

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei114 – 298185Missing in isoform 4. 1 PublicationVSP_027347Add
    BLAST
    Alternative sequencei114 – 234121Missing in isoform 3. 1 PublicationVSP_027348Add
    BLAST
    Alternative sequencei114 – 16350Missing in isoform 2. 2 PublicationsVSP_027349Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052915 mRNA. Translation: BAB59018.1.
    AB052916 mRNA. Translation: BAB79261.1.
    AB052917 mRNA. Translation: BAB79262.1.
    AB052918 mRNA. Translation: BAB79263.1.
    AB018304 mRNA. Translation: BAA34481.2.
    AL449266 Genomic DNA. Translation: CAI14363.1.
    AL449266 Genomic DNA. Translation: CAI14364.1.
    AL449266 Genomic DNA. Translation: CAI14365.1.
    AL449266 Genomic DNA. Translation: CAI14366.1.
    CH471122 Genomic DNA. Translation: EAW56345.1.
    CH471122 Genomic DNA. Translation: EAW56346.1.
    BC002939 mRNA. Translation: AAH02939.1.
    CCDSiCCDS41362.1. [Q96S66-1]
    CCDS60214.1. [Q96S66-4]
    CCDS60215.1. [Q96S66-3]
    CCDS793.1. [Q96S66-2]
    RefSeqiNP_001041675.1. NM_001048210.2. [Q96S66-1]
    NP_001265131.1. NM_001278202.1. [Q96S66-3]
    NP_001265132.1. NM_001278203.1. [Q96S66-4]
    NP_055942.1. NM_015127.4. [Q96S66-2]
    UniGeneiHs.658489.

    Genome annotation databases

    EnsembliENST00000302500; ENSP00000306552; ENSG00000121940. [Q96S66-3]
    ENST00000348264; ENSP00000337243; ENSG00000121940. [Q96S66-4]
    ENST00000356970; ENSP00000349456; ENSG00000121940. [Q96S66-1]
    ENST00000369968; ENSP00000358985; ENSG00000121940. [Q96S66-4]
    ENST00000369969; ENSP00000358986; ENSG00000121940. [Q96S66-3]
    ENST00000369970; ENSP00000358987; ENSG00000121940. [Q96S66-2]
    GeneIDi23155.
    KEGGihsa:23155.
    UCSCiuc001dwf.2. human. [Q96S66-1]
    uc001dwg.2. human. [Q96S66-2]
    uc009wes.2. human. [Q96S66-3]
    uc009wet.2. human. [Q96S66-4]

    Polymorphism databases

    DMDMi74752121.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052915 mRNA. Translation: BAB59018.1 .
    AB052916 mRNA. Translation: BAB79261.1 .
    AB052917 mRNA. Translation: BAB79262.1 .
    AB052918 mRNA. Translation: BAB79263.1 .
    AB018304 mRNA. Translation: BAA34481.2 .
    AL449266 Genomic DNA. Translation: CAI14363.1 .
    AL449266 Genomic DNA. Translation: CAI14364.1 .
    AL449266 Genomic DNA. Translation: CAI14365.1 .
    AL449266 Genomic DNA. Translation: CAI14366.1 .
    CH471122 Genomic DNA. Translation: EAW56345.1 .
    CH471122 Genomic DNA. Translation: EAW56346.1 .
    BC002939 mRNA. Translation: AAH02939.1 .
    CCDSi CCDS41362.1. [Q96S66-1 ]
    CCDS60214.1. [Q96S66-4 ]
    CCDS60215.1. [Q96S66-3 ]
    CCDS793.1. [Q96S66-2 ]
    RefSeqi NP_001041675.1. NM_001048210.2. [Q96S66-1 ]
    NP_001265131.1. NM_001278202.1. [Q96S66-3 ]
    NP_001265132.1. NM_001278203.1. [Q96S66-4 ]
    NP_055942.1. NM_015127.4. [Q96S66-2 ]
    UniGenei Hs.658489.

    3D structure databases

    ProteinModelPortali Q96S66.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116769. 2 interactions.
    IntActi Q96S66. 2 interactions.
    STRINGi 9606.ENSP00000349456.

    Protein family/group databases

    TCDBi 1.A.36.1.1. the intracellular chloride channel (icc) family.

    PTM databases

    PhosphoSitei Q96S66.

    Polymorphism databases

    DMDMi 74752121.

    Proteomic databases

    MaxQBi Q96S66.
    PaxDbi Q96S66.
    PRIDEi Q96S66.

    Protocols and materials databases

    DNASUi 23155.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302500 ; ENSP00000306552 ; ENSG00000121940 . [Q96S66-3 ]
    ENST00000348264 ; ENSP00000337243 ; ENSG00000121940 . [Q96S66-4 ]
    ENST00000356970 ; ENSP00000349456 ; ENSG00000121940 . [Q96S66-1 ]
    ENST00000369968 ; ENSP00000358985 ; ENSG00000121940 . [Q96S66-4 ]
    ENST00000369969 ; ENSP00000358986 ; ENSG00000121940 . [Q96S66-3 ]
    ENST00000369970 ; ENSP00000358987 ; ENSG00000121940 . [Q96S66-2 ]
    GeneIDi 23155.
    KEGGi hsa:23155.
    UCSCi uc001dwf.2. human. [Q96S66-1 ]
    uc001dwg.2. human. [Q96S66-2 ]
    uc009wes.2. human. [Q96S66-3 ]
    uc009wet.2. human. [Q96S66-4 ]

    Organism-specific databases

    CTDi 23155.
    GeneCardsi GC01M109472.
    HGNCi HGNC:29675. CLCC1.
    HPAi HPA009087.
    HPA013210.
    neXtProti NX_Q96S66.
    PharmGKBi PA142672105.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44384.
    HOGENOMi HOG000231351.
    HOVERGENi HBG060364.
    InParanoidi Q96S66.
    OMAi SWTYKDD.
    OrthoDBi EOG7B8S3V.
    PhylomeDBi Q96S66.
    TreeFami TF328890.

    Miscellaneous databases

    GeneWikii CLCC1.
    GenomeRNAii 23155.
    NextBioi 44493.
    PROi Q96S66.

    Gene expression databases

    ArrayExpressi Q96S66.
    Bgeei Q96S66.
    CleanExi HS_CLCC1.
    Genevestigatori Q96S66.

    Family and domain databases

    InterProi IPR009231. Chloride_chnl_CLIC-like.
    [Graphical view ]
    Pfami PF05934. MCLC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel chloride channel expressed in the endoplasmic reticulum, Golgi apparatus, and nucleus."
      Nagasawa M., Kanzaki M., Iino Y., Morishita Y., Kojima I.
      J. Biol. Chem. 276:20413-20418(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
    2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Skin.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
      J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438; SER-464; SER-509; SER-524 AND SER-532, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-482; SER-524 AND SER-532, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCLCC1_HUMAN
    AccessioniPrimary (citable) accession number: Q96S66
    Secondary accession number(s): O94861
    , Q8WYP8, Q8WYP9, Q9BU25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3