Chloride channel CLIC-like protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chloride channel activity Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG 
        60         70         80         90        100
EKDVSPDLSC ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY 
       110        120        130        140        150
LNKILIEAGK LGLPDENKGD MHYDAEIILK RETLLEIQKF LNGEDWKPGA 
       160        170        180        190        200
LDDALSDILI NFKFHDFETW KWRFEDSFGV DPYNVLMVLL CLLCIVVLVA 
       210        220        230        240        250
TELWTYVRWY TQLRRVLIIS FLFSLGWNWM YLYKLAFAQH QAEVAKMEPL 
       260        270        280        290        300
NNVCAKKMDW TGSIWEWFRS SWTYKDDPCQ KYYELLLVNP IWLVPPTKAL 
       310        320        330        340        350
AVTFTTFVTE PLKHIGKGTG EFIKALMKEI PALLHLPVLI IMALAILSFC 
       360        370        380        390        400
YGAGKSVHVL RHIGGPESEP PQALRPRDRR RQEEIDYRPD GGAGDADFHY 
       410        420        430        440        450
RGQMGPTEQG PYAKTYEGRR EILRERDVDL RFQTGNKSPE VLRAFDVPDA 
       460        470        480        490        500
EAREHPTVVP SHKSPVLDTK PKETGGILGE GTPKESSTES SQSAKPVSGQ 
       510        520        530        540        550
DTSGNTEGSP AAEKAQLKSE AAGSPDQGST YSPARGVAGP RGQDPVSSPC 

G                                                      

        10         20         30         40         50
MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG 
        60         70         80         90        100
EKDVSPDLSC ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY 
       110        120        130        140        150
LNKILIEAGK LGLFHDFETW KWRFEDSFGV DPYNVLMVLL CLLCIVVLVA 
       160        170        180        190        200
TELWTYVRWY TQLRRVLIIS FLFSLGWNWM YLYKLAFAQH QAEVAKMEPL 
       210        220        230        240        250
NNVCAKKMDW TGSIWEWFRS SWTYKDDPCQ KYYELLLVNP IWLVPPTKAL 
       260        270        280        290        300
AVTFTTFVTE PLKHIGKGTG EFIKALMKEI PALLHLPVLI IMALAILSFC 
       310        320        330        340        350
YGAGKSVHVL RHIGGPESEP PQALRPRDRR RQEEIDYRPD GGAGDADFHY 
       360        370        380        390        400
RGQMGPTEQG PYAKTYEGRR EILRERDVDL RFQTGNKSPE VLRAFDVPDA 
       410        420        430        440        450
EAREHPTVVP SHKSPVLDTK PKETGGILGE GTPKESSTES SQSAKPVSGQ 
       460        470        480        490        500
DTSGNTEGSP AAEKAQLKSE AAGSPDQGST YSPARGVAGP RGQDPVSSPC 

G                                                      

        10         20         30         40         50
MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG 
        60         70         80         90        100
EKDVSPDLSC ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY 
       110        120        130        140        150
LNKILIEAGK LGLLAFAQHQ AEVAKMEPLN NVCAKKMDWT GSIWEWFRSS 
       160        170        180        190        200
WTYKDDPCQK YYELLLVNPI WLVPPTKALA VTFTTFVTEP LKHIGKGTGE 
       210        220        230        240        250
FIKALMKEIP ALLHLPVLII MALAILSFCY GAGKSVHVLR HIGGPESEPP 
       260        270        280        290        300
QALRPRDRRR QEEIDYRPDG GAGDADFHYR GQMGPTEQGP YAKTYEGRRE 
       310        320        330        340        350
ILRERDVDLR FQTGNKSPEV LRAFDVPDAE AREHPTVVPS HKSPVLDTKP 
       360        370        380        390        400
KETGGILGEG TPKESSTESS QSAKPVSGQD TSGNTEGSPA AEKAQLKSEA 
       410        420        430
AGSPDQGSTY SPARGVAGPR GQDPVSSPCG                       

        10         20         30         40         50
MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG 
        60         70         80         90        100
EKDVSPDLSC ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY 
       110        120        130        140        150
LNKILIEAGK LGLALAVTFT TFVTEPLKHI GKGTGEFIKA LMKEIPALLH 
       160        170        180        190        200
LPVLIIMALA ILSFCYGAGK SVHVLRHIGG PESEPPQALR PRDRRRQEEI 
       210        220        230        240        250
DYRPDGGAGD ADFHYRGQMG PTEQGPYAKT YEGRREILRE RDVDLRFQTG 
       260        270        280        290        300
NKSPEVLRAF DVPDAEAREH PTVVPSHKSP VLDTKPKETG GILGEGTPKE 
       310        320        330        340        350
SSTESSQSAK PVSGQDTSGN TEGSPAAEKA QLKSEAAGSP DQGSTYSPAR 
       360 
GVAGPRGQDP VSSPCG                                      

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ