Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cysteine/serine-rich nuclear protein 1

Gene

CSRNP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144655-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine/serine-rich nuclear protein 1
Short name:
CSRNP-1
Alternative name(s):
Axin-1 up-regulated gene 1 protein
Protein URAX1
TGF-beta-induced apoptosis protein 3
Short name:
TAIP-3
Gene namesi
Name:CSRNP1
Synonyms:AXUD1, TAIP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14300. CSRNP1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64651.
OpenTargetsiENSG00000144655.
PharmGKBiPA25200.

Polymorphism and mutation databases

BioMutaiCSRNP1.
DMDMi308153432.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147861 – 589Cysteine/serine-rich nuclear protein 1Add BLAST589

Proteomic databases

PaxDbiQ96S65.
PeptideAtlasiQ96S65.
PRIDEiQ96S65.

PTM databases

iPTMnetiQ96S65.
PhosphoSitePlusiQ96S65.

Expressioni

Tissue specificityi

Ubiquitous. Most abundantly expressed in lung, placenta, skeletal muscle, pancreas and leukocyte. Frequently down-regulated in lung, kidney, liver and colon cancers compared with their corresponding normal tissues.1 Publication

Gene expression databases

BgeeiENSG00000144655.
CleanExiHS_AXUD1.
ExpressionAtlasiQ96S65. baseline and differential.
GenevisibleiQ96S65. HS.

Organism-specific databases

HPAiHPA045207.
HPA058463.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AQP1P299723EBI-4311573,EBI-745213
PPP1CAP621366EBI-4311573,EBI-357253
PPP1CCP368733EBI-4311573,EBI-356283
TCEANCQ8N8B73EBI-4311573,EBI-954696
ZNF417Q8TAU33EBI-4311573,EBI-740727
ZNF587Q96SQ53EBI-4311573,EBI-6427977

Protein-protein interaction databases

BioGridi122227. 8 interactors.
IntActiQ96S65. 8 interactors.
STRINGi9606.ENSP00000273153.

Structurei

3D structure databases

ProteinModelPortaliQ96S65.
SMRiQ96S65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 40Ser-richAdd BLAST24
Compositional biasi237 – 275Cys-richAdd BLAST39

Sequence similaritiesi

Belongs to the AXUD1 family.Curated

Phylogenomic databases

eggNOGiKOG3813. Eukaryota.
ENOG410XREB. LUCA.
GeneTreeiENSGT00390000015510.
HOGENOMiHOG000039987.
InParanoidiQ96S65.
KOiK17494.
OMAiPRHSACR.
OrthoDBiEOG091G04PA.
PhylomeDBiQ96S65.
TreeFamiTF323969.

Family and domain databases

InterProiIPR031972. CSRNP_N.
IPR023260. Cys/Ser-rich_nuc_prot.
[Graphical view]
PANTHERiPTHR13580. PTHR13580. 1 hit.
PfamiPF16019. CSRNP_N. 1 hit.
[Graphical view]
PRINTSiPR02031. CYSSERRICHNP.

Sequencei

Sequence statusi: Complete.

Q96S65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGLLKRKFD QLDEDNSSVS SSSSSSGCQS RSCSPSSSVS RAWDSEEEGP
60 70 80 90 100
WDQMPLPDRD FCGPRSFTPL SILKRARRER PGRVAFDGIT VFYFPRCQGF
110 120 130 140 150
TSVPSRGGCT LGMALRHSAC RRFSLAEFAQ EQARARHEKL RQRLKEEKLE
160 170 180 190 200
MLQWKLSAAG VPQAEAGLPP VVDAIDDASV EEDLAVAVAG GRLEEVSFLQ
210 220 230 240 250
PYPARRRRAL LRASGVRRID REEKRELQAL RQSREDCGCH CDRICDPETC
260 270 280 290 300
SCSLAGIKCQ MDHTAFPCGC CREGCENPMG RVEFNQARVQ THFIHTLTRL
310 320 330 340 350
QLEQEAESFR ELEAPAQGSP PSPGEEALVP TFPLAKPPMN NELGDNSCSS
360 370 380 390 400
DMTDSSTASS SASGTSEAPD CPTHPGLPGP GFQPGVDDDS LARILSFSDS
410 420 430 440 450
DFGGEEEEEE EGSVGNLDNL SCFHPADIFG TSDPGGLASW THSYSGCSFT
460 470 480 490 500
SGVLDENANL DASCFLNGGL EGSREGSLPG TSVPPSMDAG RSSSVDLSLS
510 520 530 540 550
SCDSFELLQA LPDYSLGPHY TSQKVSDSLD NIEAPHFPLP GLSPPGDASS
560 570 580
CFLESLMGFS EPAAEALDPF IDSQFEDTVP ASLMEPVPV
Length:589
Mass (Da):63,508
Last modified:October 5, 2010 - v2
Checksum:iBAF4951B6F96ADD8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055100453V → I.3 PublicationsCorresponds to variant rs1274958dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053121 mRNA. Translation: BAB61065.1.
AB063301 mRNA. Translation: BAB79450.1.
AC092053 Genomic DNA. No translation available.
BC038949 mRNA. Translation: AAH38949.1.
AL117565 mRNA. Translation: CAH10719.1.
CCDSiCCDS2682.1.
RefSeqiNP_001307489.1. NM_001320560.1.
NP_149016.2. NM_033027.3.
XP_016862537.1. XM_017007048.1.
UniGeneiHs.370950.

Genome annotation databases

EnsembliENST00000273153; ENSP00000273153; ENSG00000144655.
ENST00000514182; ENSP00000422532; ENSG00000144655.
GeneIDi64651.
KEGGihsa:64651.
UCSCiuc003cjg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053121 mRNA. Translation: BAB61065.1.
AB063301 mRNA. Translation: BAB79450.1.
AC092053 Genomic DNA. No translation available.
BC038949 mRNA. Translation: AAH38949.1.
AL117565 mRNA. Translation: CAH10719.1.
CCDSiCCDS2682.1.
RefSeqiNP_001307489.1. NM_001320560.1.
NP_149016.2. NM_033027.3.
XP_016862537.1. XM_017007048.1.
UniGeneiHs.370950.

3D structure databases

ProteinModelPortaliQ96S65.
SMRiQ96S65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122227. 8 interactors.
IntActiQ96S65. 8 interactors.
STRINGi9606.ENSP00000273153.

PTM databases

iPTMnetiQ96S65.
PhosphoSitePlusiQ96S65.

Polymorphism and mutation databases

BioMutaiCSRNP1.
DMDMi308153432.

Proteomic databases

PaxDbiQ96S65.
PeptideAtlasiQ96S65.
PRIDEiQ96S65.

Protocols and materials databases

DNASUi64651.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273153; ENSP00000273153; ENSG00000144655.
ENST00000514182; ENSP00000422532; ENSG00000144655.
GeneIDi64651.
KEGGihsa:64651.
UCSCiuc003cjg.4. human.

Organism-specific databases

CTDi64651.
DisGeNETi64651.
GeneCardsiCSRNP1.
H-InvDBHIX0003186.
HGNCiHGNC:14300. CSRNP1.
HPAiHPA045207.
HPA058463.
MIMi606458. gene.
neXtProtiNX_Q96S65.
OpenTargetsiENSG00000144655.
PharmGKBiPA25200.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3813. Eukaryota.
ENOG410XREB. LUCA.
GeneTreeiENSGT00390000015510.
HOGENOMiHOG000039987.
InParanoidiQ96S65.
KOiK17494.
OMAiPRHSACR.
OrthoDBiEOG091G04PA.
PhylomeDBiQ96S65.
TreeFamiTF323969.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144655-MONOMER.

Miscellaneous databases

ChiTaRSiCSRNP1. human.
GenomeRNAii64651.
PROiQ96S65.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144655.
CleanExiHS_AXUD1.
ExpressionAtlasiQ96S65. baseline and differential.
GenevisibleiQ96S65. HS.

Family and domain databases

InterProiIPR031972. CSRNP_N.
IPR023260. Cys/Ser-rich_nuc_prot.
[Graphical view]
PANTHERiPTHR13580. PTHR13580. 1 hit.
PfamiPF16019. CSRNP_N. 1 hit.
[Graphical view]
PRINTSiPR02031. CYSSERRICHNP.
ProtoNetiSearch...

Entry informationi

Entry nameiCSRN1_HUMAN
AccessioniPrimary (citable) accession number: Q96S65
Secondary accession number(s): Q69YY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.