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Protein

GPI transamidase component PIG-S

Gene

PIGS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.1 Publication

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • attachment of GPI anchor to protein Source: UniProtKB

Keywordsi

Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-162791 Attachment of GPI anchor to uPAR
UniPathwayiUPA00196

Names & Taxonomyi

Protein namesi
Recommended name:
GPI transamidase component PIG-S
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class S protein
Gene namesi
Name:PIGS
ORF Names:UNQ1873/PRO4316
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000087111.20
HGNCiHGNC:14937 PIGS
MIMi610271 gene
neXtProtiNX_Q96S52

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 18CytoplasmicSequence analysisAdd BLAST17
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 520LumenalSequence analysisAdd BLAST481
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Topological domaini542 – 555CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi94005
OpenTargetsiENSG00000087111
PharmGKBiPA33301

Polymorphism and mutation databases

BioMutaiPIGS
DMDMi21759353

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002186042 – 555GPI transamidase component PIG-SAdd BLAST554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96S52
MaxQBiQ96S52
PaxDbiQ96S52
PeptideAtlasiQ96S52
PRIDEiQ96S52

PTM databases

iPTMnetiQ96S52
PhosphoSitePlusiQ96S52

Expressioni

Gene expression databases

BgeeiENSG00000087111
CleanExiHS_PIGS
ExpressionAtlasiQ96S52 baseline and differential
GenevisibleiQ96S52 HS

Organism-specific databases

HPAiHPA018149

Interactioni

Subunit structurei

Forms a complex with PIGK/GPI8, PIGT, PIGU and GAA1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125082, 45 interactors
CORUMiQ96S52
IntActiQ96S52, 32 interactors
MINTiQ96S52
STRINGi9606.ENSP00000309430

Structurei

3D structure databases

ProteinModelPortaliQ96S52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2459 Eukaryota
ENOG410XR9U LUCA
GeneTreeiENSGT00390000017203
HOGENOMiHOG000067980
HOVERGENiHBG031822
InParanoidiQ96S52
KOiK05291
OMAiKYKMKIK
OrthoDBiEOG091G06XK
PhylomeDBiQ96S52
TreeFamiTF105857

Family and domain databases

InterProiView protein in InterPro
IPR019540 PtdIno-glycan_biosynth_class_S
PANTHERiPTHR21072 PTHR21072, 1 hit
PfamiView protein in Pfam
PF10510 PIG-S, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96S52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAGAAATH LEVARGKRAA LFFAAVAIVL GLPLWWKTTE TYRASLPYSQ
60 70 80 90 100
ISGLNALQLR LMVPVTVVFT RESVPLDDQE KLPFTVVHER EIPLKYKMKI
110 120 130 140 150
KCRFQKAYRR ALDHEEEALS SGSVQEAEAM LDEPQEQAEG SLTVYVISEH
160 170 180 190 200
SSLLPQDMMS YIGPKRTAVV RGIMHREAFN IIGRRIVQVA QAMSLTEDVL
210 220 230 240 250
AAALADHLPE DKWSAEKRRP LKSSLGYEIT FSLLNPDPKS HDVYWDIEGA
260 270 280 290 300
VRRYVQPFLN ALGAAGNFSV DSQILYYAML GVNPRFDSAS SSYYLDMHSL
310 320 330 340 350
PHVINPVESR LGSSAASLYP VLNFLLYVPE LAHSPLYIQD KDGAPVATNA
360 370 380 390 400
FHSPRWGGIM VYNVDSKTYN ASVLPVRVEV DMVRVMEVFL AQLRLLFGIA
410 420 430 440 450
QPQLPPKCLL SGPTSEGLMT WELDRLLWAR SVENLATATT TLTSLAQLLG
460 470 480 490 500
KISNIVIKDD VASEVYKAVA AVQKSAEELA SGHLASAFVA SQEAVTSSEL
510 520 530 540 550
AFFDPSLLHL LYFPDDQKFA IYIPLFLPMA VPILLSLVKI FLETRKSWRK

PEKTD
Length:555
Mass (Da):61,656
Last modified:January 23, 2007 - v3
Checksum:iA20B323C5475EF4F
GO
Isoform 2 (identifier: Q96S52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MAAAGAAATHL → MPS

Note: No experimental confirmation available.
Show »
Length:547
Mass (Da):61,005
Checksum:iFE15DAA8222209B8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036510159M → I in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_053582253R → H. Corresponds to variant dbSNP:rs34669811Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0131581 – 11MAAAGAAATHL → MPS in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB057723 mRNA Translation: BAB60853.1
AY359112 mRNA Translation: AAQ89470.1
BC069228 mRNA Translation: AAH69228.1
CCDSiCCDS11235.1 [Q96S52-1]
RefSeqiNP_149975.1, NM_033198.3 [Q96S52-1]
UniGeneiHs.462550

Genome annotation databases

EnsembliENST00000308360; ENSP00000309430; ENSG00000087111 [Q96S52-1]
ENST00000395346; ENSP00000378755; ENSG00000087111 [Q96S52-2]
GeneIDi94005
KEGGihsa:94005
UCSCiuc002hbn.3 human [Q96S52-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPIGS_HUMAN
AccessioniPrimary (citable) accession number: Q96S52
Secondary accession number(s): Q6UVX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

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