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Q96S38

- KS6C1_HUMAN

UniProt

Q96S38 - KS6C1_HUMAN

Protein

Ribosomal protein S6 kinase delta-1

Gene

RPS6KC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (02 May 2006)
      Previous versions | rss
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    Functioni

    May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei820 – 8201ATPPROSITE-ProRule annotation
    Active sitei929 – 9291Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi801 – 8099ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphatidylinositol binding Source: InterPro
    3. protein binding Source: UniProtKB
    4. protein serine/threonine kinase activity Source: ProtInc

    GO - Biological processi

    1. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ96S38.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal protein S6 kinase delta-1 (EC:2.7.11.1)
    Short name:
    S6K-delta-1
    Alternative name(s):
    52 kDa ribosomal protein S6 kinase
    Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein
    SPHK1-binding protein
    Gene namesi
    Name:RPS6KC1
    Synonyms:RPK118
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10439. RPS6KC1.

    Subcellular locationi

    Cytoplasm 1 Publication. Membrane 1 Publication
    Note: Also found in some small dot-like or ring-shaped early endosome structures.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. early endosome Source: UniProtKB
    3. intracellular membrane-bounded organelle Source: HPA
    4. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34854.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10661066Ribosomal protein S6 kinase delta-1PRO_0000233127Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei423 – 4231Phosphoserine1 Publication
    Modified residuei427 – 4271Phosphoserine1 Publication
    Modified residuei605 – 6051PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96S38.
    PaxDbiQ96S38.
    PRIDEiQ96S38.

    PTM databases

    PhosphoSiteiQ96S38.

    Expressioni

    Tissue specificityi

    Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon.1 Publication

    Gene expression databases

    ArrayExpressiQ96S38.
    BgeeiQ96S38.
    CleanExiHS_RPS6KC1.
    GenevestigatoriQ96S38.

    Organism-specific databases

    HPAiHPA026531.
    HPA031565.

    Interactioni

    Subunit structurei

    Interacts with SPHK1 and phosphatidylinositol 3-phosphate.1 Publication

    Protein-protein interaction databases

    BioGridi117810. 4 interactions.
    IntActiQ96S38. 4 interactions.
    MINTiMINT-1036906.
    STRINGi9606.ENSP00000355927.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96S38.
    SMRiQ96S38. Positions 336-467, 799-1066.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 132125PXPROSITE-ProRule annotationAdd
    BLAST
    Domaini277 – 30529MITAdd
    BLAST
    Domaini344 – 445102Protein kinase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini794 – 1056263Protein kinase 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.PROSITE-ProRule annotation
    Contains 1 MIT domain.Curated
    Contains 2 protein kinase domains.PROSITE-ProRule annotation
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000049101.
    HOVERGENiHBG078266.
    InParanoidiQ96S38.
    OMAiVPNMVCL.
    OrthoDBiEOG78PV8C.
    PhylomeDBiQ96S38.
    TreeFamiTF323964.

    Family and domain databases

    Gene3Di1.20.58.280. 1 hit.
    3.30.1520.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR007330. MIT.
    IPR001683. Phox.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF04212. MIT. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF00787. PX. 1 hit.
    [Graphical view]
    SMARTiSM00745. MIT. 1 hit.
    SM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF116846. SSF116846. 1 hit.
    SSF56112. SSF56112. 2 hits.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50195. PX. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96S38-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTSYRERSAD LARFYTVTEP QRHPRGYTVY KVTARVVSRR NPEDVQEIIV     50
    WKRYSDFKKL HKELWQIHKN LFRHSELFPP FAKGIVFGRF DETVIEERRQ 100
    CAEDLLQFSA NIPALYNSKQ LEDFFKGGII NDSSELIGPA EAHSDSLIDT 150
    FPECSTEGFS SDSDLVSLTV DVDSLAELDD GMASNQNSPI RTFGLNLSSD 200
    SSALGAVASD SEQSKTEEER ESRSLFPGSL KPKLGKRDYL EKAGELIKLA 250
    LKKEEEDDYE AASDFYRKGV DLLLEGVQGE SSPTRREAVK RRTAEYLMRA 300
    ESISSLYGKP QLDDVSQPPG SLSSRPLWNL RSPAEELKAF RVLGVIDKVL 350
    LVMDTRTEQT FILKGLRKSS EYSRNRKTII PRCVPNMVCL HKYIISEESV 400
    FLVLQHAEGG KLWSYISKFL NRSPEESFDI KEVKKPTLAK VHLQQPTSSP 450
    QDSSSFESRG SDGGSMLKAL PLKSSLTPSS QDDSNQEDDG QDSSPKWPDS 500
    GSSSEEECTT SYLTLCNEYG QEKIEPGSLN EEPFMKTEGN GVDTKAIKSF 550
    PAHLAADSDS PSTQLRAHEL KFFPNDDPEA VSSPRTSDSL SRSKNSPMEF 600
    FRIDSKDSAS ELLGLDFGEK LYSLKSEPLK PFFTLPDGDS ASRSFNTSES 650
    KVEFKAQDTI SRGSDDSVPV ISFKDAAFDD VSGTDEGRPD LLVNLPGELE 700
    STREAAAMGP TKFTQTNIGI IENKLLEAPD VLCLRLSTEQ CQAHEEKGIE 750
    ELSDPSGPKS YSITEKHYAQ EDPRMLFVAA VDHSSSGDMS LLPSSDPKFQ 800
    GLGVVESAVT ANNTEESLFR ICSPLSGANE YIASTDTLKT EEVLLFTDQT 850
    DDLAKEEPTS LFQRDSETKG ESGLVLEGDK EIHQIFEDLD KKLALASRFY 900
    IPEGCIQRWA AEMVVALDAL HREGIVCRDL NPNNILLNDR GHIQLTYFSR 950
    WSEVEDSCDS DAIERMYCAP EVGAITEETE ACDWWSLGAV LFELLTGKTL 1000
    VECHPAGINT HTTLNMPECV SEEARSLIQQ LLQFNPLERL GAGVAGVEDI 1050
    KSHPFFTPVD WAELMR 1066
    Length:1,066
    Mass (Da):118,682
    Last modified:May 2, 2006 - v2
    Checksum:i670EE5965F3B8274
    GO
    Isoform 2 (identifier: Q96S38-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         36-47: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,054
    Mass (Da):117,273
    Checksum:iF514E37BF7CCC4F0
    GO

    Sequence cautioni

    The sequence CAB92850.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 351R → G in BAB63956. (PubMed:12077123)Curated
    Sequence conflicti250 – 2501A → V in BAB63956. (PubMed:12077123)Curated
    Sequence conflicti1065 – 10651Missing(PubMed:10552933)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421P → T.1 Publication
    Corresponds to variant rs56087470 [ dbSNP | Ensembl ].
    VAR_040647
    Natural varianti96 – 961E → K.1 Publication
    Corresponds to variant rs56032860 [ dbSNP | Ensembl ].
    VAR_040648
    Natural varianti319 – 3191P → L.1 Publication
    Corresponds to variant rs56369827 [ dbSNP | Ensembl ].
    VAR_040649
    Natural varianti424 – 4241P → L.1 Publication
    Corresponds to variant rs56183862 [ dbSNP | Ensembl ].
    VAR_040650
    Natural varianti546 – 5461A → P.1 Publication
    Corresponds to variant rs35281247 [ dbSNP | Ensembl ].
    VAR_040651
    Natural varianti554 – 5541L → I in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication
    VAR_040652
    Natural varianti561 – 5611P → R.
    Corresponds to variant rs17020314 [ dbSNP | Ensembl ].
    VAR_051635
    Natural varianti575 – 5751N → S.1 Publication
    Corresponds to variant rs56060894 [ dbSNP | Ensembl ].
    VAR_040653
    Natural varianti663 – 6631G → A in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
    VAR_040654
    Natural varianti853 – 8531L → F.1 Publication
    Corresponds to variant rs34080597 [ dbSNP | Ensembl ].
    VAR_040655
    Natural varianti1003 – 10031C → Y in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040656
    Natural varianti1022 – 10221E → K in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication
    VAR_040657

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei36 – 4712Missing in isoform 2. 1 PublicationVSP_046333Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070706 mRNA. Translation: BAB63956.1.
    AF477978 mRNA. Translation: AAL84818.1.
    AK122921 mRNA. No translation available.
    AK122989 mRNA. Translation: BAG53836.1.
    AL645860, AL512449, AL583826 Genomic DNA. Translation: CAH70703.1.
    AL645860, AL512449, AL583826 Genomic DNA. Translation: CAH70704.1.
    AL512449, AL583826, AL645860 Genomic DNA. Translation: CAH71999.1.
    AL512449, AL583826, AL645860 Genomic DNA. Translation: CAH72000.1.
    AL583826, AL512449, AL645860 Genomic DNA. Translation: CAH73804.1.
    AL583826, AL512449, AL645860 Genomic DNA. Translation: CAH73805.1.
    CH471100 Genomic DNA. Translation: EAW93362.1.
    CH471100 Genomic DNA. Translation: EAW93363.1.
    BC104769 mRNA. Translation: AAI04770.1.
    AF037447 mRNA. Translation: AAF13027.1.
    AL356893 mRNA. Translation: CAB92850.1. Different initiation.
    CCDSiCCDS1513.1. [Q96S38-1]
    CCDS44317.1. [Q96S38-2]
    RefSeqiNP_001129610.1. NM_001136138.2. [Q96S38-2]
    NP_001274147.1. NM_001287218.1.
    NP_001274148.1. NM_001287219.1.
    NP_001274149.1. NM_001287220.1.
    NP_001274150.1. NM_001287221.1.
    NP_036556.2. NM_012424.4. [Q96S38-1]
    UniGeneiHs.591416.

    Genome annotation databases

    EnsembliENST00000366959; ENSP00000355926; ENSG00000136643. [Q96S38-2]
    ENST00000366960; ENSP00000355927; ENSG00000136643. [Q96S38-1]
    GeneIDi26750.
    KEGGihsa:26750.
    UCSCiuc001hke.3. human. [Q96S38-1]

    Polymorphism databases

    DMDMi94717650.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070706 mRNA. Translation: BAB63956.1 .
    AF477978 mRNA. Translation: AAL84818.1 .
    AK122921 mRNA. No translation available.
    AK122989 mRNA. Translation: BAG53836.1 .
    AL645860 , AL512449 , AL583826 Genomic DNA. Translation: CAH70703.1 .
    AL645860 , AL512449 , AL583826 Genomic DNA. Translation: CAH70704.1 .
    AL512449 , AL583826 , AL645860 Genomic DNA. Translation: CAH71999.1 .
    AL512449 , AL583826 , AL645860 Genomic DNA. Translation: CAH72000.1 .
    AL583826 , AL512449 , AL645860 Genomic DNA. Translation: CAH73804.1 .
    AL583826 , AL512449 , AL645860 Genomic DNA. Translation: CAH73805.1 .
    CH471100 Genomic DNA. Translation: EAW93362.1 .
    CH471100 Genomic DNA. Translation: EAW93363.1 .
    BC104769 mRNA. Translation: AAI04770.1 .
    AF037447 mRNA. Translation: AAF13027.1 .
    AL356893 mRNA. Translation: CAB92850.1 . Different initiation.
    CCDSi CCDS1513.1. [Q96S38-1 ]
    CCDS44317.1. [Q96S38-2 ]
    RefSeqi NP_001129610.1. NM_001136138.2. [Q96S38-2 ]
    NP_001274147.1. NM_001287218.1.
    NP_001274148.1. NM_001287219.1.
    NP_001274149.1. NM_001287220.1.
    NP_001274150.1. NM_001287221.1.
    NP_036556.2. NM_012424.4. [Q96S38-1 ]
    UniGenei Hs.591416.

    3D structure databases

    ProteinModelPortali Q96S38.
    SMRi Q96S38. Positions 336-467, 799-1066.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117810. 4 interactions.
    IntActi Q96S38. 4 interactions.
    MINTi MINT-1036906.
    STRINGi 9606.ENSP00000355927.

    Chemistry

    ChEMBLi CHEMBL1795193.

    PTM databases

    PhosphoSitei Q96S38.

    Polymorphism databases

    DMDMi 94717650.

    Proteomic databases

    MaxQBi Q96S38.
    PaxDbi Q96S38.
    PRIDEi Q96S38.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366959 ; ENSP00000355926 ; ENSG00000136643 . [Q96S38-2 ]
    ENST00000366960 ; ENSP00000355927 ; ENSG00000136643 . [Q96S38-1 ]
    GeneIDi 26750.
    KEGGi hsa:26750.
    UCSCi uc001hke.3. human. [Q96S38-1 ]

    Organism-specific databases

    CTDi 26750.
    GeneCardsi GC01P213224.
    HGNCi HGNC:10439. RPS6KC1.
    HPAi HPA026531.
    HPA031565.
    neXtProti NX_Q96S38.
    PharmGKBi PA34854.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000049101.
    HOVERGENi HBG078266.
    InParanoidi Q96S38.
    OMAi VPNMVCL.
    OrthoDBi EOG78PV8C.
    PhylomeDBi Q96S38.
    TreeFami TF323964.

    Enzyme and pathway databases

    SignaLinki Q96S38.

    Miscellaneous databases

    ChiTaRSi RPS6KC1. human.
    GeneWikii RPS6KC1.
    GenomeRNAii 26750.
    NextBioi 49115.
    PROi Q96S38.

    Gene expression databases

    ArrayExpressi Q96S38.
    Bgeei Q96S38.
    CleanExi HS_RPS6KC1.
    Genevestigatori Q96S38.

    Family and domain databases

    Gene3Di 1.20.58.280. 1 hit.
    3.30.1520.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR007330. MIT.
    IPR001683. Phox.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF04212. MIT. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF00787. PX. 1 hit.
    [Graphical view ]
    SMARTi SM00745. MIT. 1 hit.
    SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF116846. SSF116846. 1 hit.
    SSF56112. SSF56112. 2 hits.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein."
      Hayashi S., Okada T., Igarashi N., Fujita T., Jahangeer S., Nakamura S.
      J. Biol. Chem. 277:33319-33324(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH SPHK1 AND PHOSPHATIDYLINOSITOL 3-PHOSPHATE, SUBCELLULAR LOCATION.
    2. Guo J.H., Yu L.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Testis.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1."
      Zhang H., Yu L., Mao N., Fu Q., Tu Q., Gao J., Zhao S.
      Genomics 61:314-318(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 598-1066 (ISOFORM 1).
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 683-1066 (ISOFORM 1).
      Tissue: Amygdala.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND SER-427, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-42; LYS-96; LEU-319; LEU-424; PRO-546; ILE-554; SER-575; ALA-663; PHE-853; TYR-1003 AND LYS-1022.

    Entry informationi

    Entry nameiKS6C1_HUMAN
    AccessioniPrimary (citable) accession number: Q96S38
    Secondary accession number(s): B1APS8
    , B3KVM4, D3DTA4, Q8TDD3, Q9NSF4, Q9UL66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3