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Q96S38 (KS6C1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribosomal protein S6 kinase delta-1

Short name=S6K-delta-1
EC=2.7.11.1
Alternative name(s):
52 kDa ribosomal protein S6 kinase
Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein
SPHK1-binding protein
Gene names
Name:RPS6KC1
Synonyms:RPK118
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1066 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with SPHK1 and phosphatidylinositol 3-phosphate. Ref.1

Subcellular location

Cytoplasm. Membrane. Note: Also found in some small dot-like or ring-shaped early endosome structures. Ref.1

Tissue specificity

Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon. Ref.1

Domain

The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.

Contains 1 MIT domain.

Contains 2 protein kinase domains.

Contains 1 PX (phox homology) domain.

Caution

Instead of Lys-820, Arg-820 is found at the binding site.

Sequence caution

The sequence CAB92850.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96S38-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96S38-2)

The sequence of this isoform differs from the canonical sequence as follows:
     36-47: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10661066Ribosomal protein S6 kinase delta-1
PRO_0000233127

Regions

Domain8 – 132125PX
Domain277 – 30529MIT
Domain344 – 445102Protein kinase 1
Domain794 – 1056263Protein kinase 2
Nucleotide binding801 – 8099ATP By similarity

Sites

Active site9291Proton acceptor By similarity
Binding site8201ATP By similarity

Amino acid modifications

Modified residue4231Phosphoserine Ref.12
Modified residue4271Phosphoserine Ref.12
Modified residue6051Phosphoserine By similarity

Natural variations

Alternative sequence36 – 4712Missing in isoform 2.
VSP_046333
Natural variant421P → T. Ref.13
Corresponds to variant rs56087470 [ dbSNP | Ensembl ].
VAR_040647
Natural variant961E → K. Ref.13
Corresponds to variant rs56032860 [ dbSNP | Ensembl ].
VAR_040648
Natural variant3191P → L. Ref.13
Corresponds to variant rs56369827 [ dbSNP | Ensembl ].
VAR_040649
Natural variant4241P → L. Ref.13
Corresponds to variant rs56183862 [ dbSNP | Ensembl ].
VAR_040650
Natural variant5461A → P. Ref.13
Corresponds to variant rs35281247 [ dbSNP | Ensembl ].
VAR_040651
Natural variant5541L → I in a lung neuroendocrine carcinoma sample; somatic mutation. Ref.13
VAR_040652
Natural variant5611P → R.
Corresponds to variant rs17020314 [ dbSNP | Ensembl ].
VAR_051635
Natural variant5751N → S. Ref.13
Corresponds to variant rs56060894 [ dbSNP | Ensembl ].
VAR_040653
Natural variant6631G → A in an ovarian mucinous carcinoma sample; somatic mutation. Ref.13
VAR_040654
Natural variant8531L → F. Ref.13
Corresponds to variant rs34080597 [ dbSNP | Ensembl ].
VAR_040655
Natural variant10031C → Y in a lung adenocarcinoma sample; somatic mutation. Ref.13
VAR_040656
Natural variant10221E → K in a breast infiltrating ductal carcinoma sample; somatic mutation. Ref.13
VAR_040657

Experimental info

Sequence conflict351R → G in BAB63956. Ref.1
Sequence conflict2501A → V in BAB63956. Ref.1
Sequence conflict10651Missing Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: 670EE5965F3B8274

FASTA1,066118,682
        10         20         30         40         50         60 
MTSYRERSAD LARFYTVTEP QRHPRGYTVY KVTARVVSRR NPEDVQEIIV WKRYSDFKKL 

        70         80         90        100        110        120 
HKELWQIHKN LFRHSELFPP FAKGIVFGRF DETVIEERRQ CAEDLLQFSA NIPALYNSKQ 

       130        140        150        160        170        180 
LEDFFKGGII NDSSELIGPA EAHSDSLIDT FPECSTEGFS SDSDLVSLTV DVDSLAELDD 

       190        200        210        220        230        240 
GMASNQNSPI RTFGLNLSSD SSALGAVASD SEQSKTEEER ESRSLFPGSL KPKLGKRDYL 

       250        260        270        280        290        300 
EKAGELIKLA LKKEEEDDYE AASDFYRKGV DLLLEGVQGE SSPTRREAVK RRTAEYLMRA 

       310        320        330        340        350        360 
ESISSLYGKP QLDDVSQPPG SLSSRPLWNL RSPAEELKAF RVLGVIDKVL LVMDTRTEQT 

       370        380        390        400        410        420 
FILKGLRKSS EYSRNRKTII PRCVPNMVCL HKYIISEESV FLVLQHAEGG KLWSYISKFL 

       430        440        450        460        470        480 
NRSPEESFDI KEVKKPTLAK VHLQQPTSSP QDSSSFESRG SDGGSMLKAL PLKSSLTPSS 

       490        500        510        520        530        540 
QDDSNQEDDG QDSSPKWPDS GSSSEEECTT SYLTLCNEYG QEKIEPGSLN EEPFMKTEGN 

       550        560        570        580        590        600 
GVDTKAIKSF PAHLAADSDS PSTQLRAHEL KFFPNDDPEA VSSPRTSDSL SRSKNSPMEF 

       610        620        630        640        650        660 
FRIDSKDSAS ELLGLDFGEK LYSLKSEPLK PFFTLPDGDS ASRSFNTSES KVEFKAQDTI 

       670        680        690        700        710        720 
SRGSDDSVPV ISFKDAAFDD VSGTDEGRPD LLVNLPGELE STREAAAMGP TKFTQTNIGI 

       730        740        750        760        770        780 
IENKLLEAPD VLCLRLSTEQ CQAHEEKGIE ELSDPSGPKS YSITEKHYAQ EDPRMLFVAA 

       790        800        810        820        830        840 
VDHSSSGDMS LLPSSDPKFQ GLGVVESAVT ANNTEESLFR ICSPLSGANE YIASTDTLKT 

       850        860        870        880        890        900 
EEVLLFTDQT DDLAKEEPTS LFQRDSETKG ESGLVLEGDK EIHQIFEDLD KKLALASRFY 

       910        920        930        940        950        960 
IPEGCIQRWA AEMVVALDAL HREGIVCRDL NPNNILLNDR GHIQLTYFSR WSEVEDSCDS 

       970        980        990       1000       1010       1020 
DAIERMYCAP EVGAITEETE ACDWWSLGAV LFELLTGKTL VECHPAGINT HTTLNMPECV 

      1030       1040       1050       1060 
SEEARSLIQQ LLQFNPLERL GAGVAGVEDI KSHPFFTPVD WAELMR 

« Hide

Isoform 2 [UniParc].

Checksum: F514E37BF7CCC4F0
Show »

FASTA1,054117,273

References

« Hide 'large scale' references
[1]"Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein."
Hayashi S., Okada T., Igarashi N., Fujita T., Jahangeer S., Nakamura S.
J. Biol. Chem. 277:33319-33324(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH SPHK1 AND PHOSPHATIDYLINOSITOL 3-PHOSPHATE, SUBCELLULAR LOCATION.
[2]Guo J.H., Yu L.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Testis.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Tissue: Brain.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[7]"Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1."
Zhang H., Yu L., Mao N., Fu Q., Tu Q., Gao J., Zhao S.
Genomics 61:314-318(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 598-1066 (ISOFORM 1).
[8]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 683-1066 (ISOFORM 1).
Tissue: Amygdala.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND SER-427, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-42; LYS-96; LEU-319; LEU-424; PRO-546; ILE-554; SER-575; ALA-663; PHE-853; TYR-1003 AND LYS-1022.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB070706 mRNA. Translation: BAB63956.1.
AF477978 mRNA. Translation: AAL84818.1.
AK122921 mRNA. No translation available.
AK122989 mRNA. Translation: BAG53836.1.
AL645860, AL512449, AL583826 Genomic DNA. Translation: CAH70703.1.
AL645860, AL512449, AL583826 Genomic DNA. Translation: CAH70704.1.
AL512449, AL583826, AL645860 Genomic DNA. Translation: CAH71999.1.
AL512449, AL583826, AL645860 Genomic DNA. Translation: CAH72000.1.
AL583826, AL512449, AL645860 Genomic DNA. Translation: CAH73804.1.
AL583826, AL512449, AL645860 Genomic DNA. Translation: CAH73805.1.
CH471100 Genomic DNA. Translation: EAW93362.1.
CH471100 Genomic DNA. Translation: EAW93363.1.
BC104769 mRNA. Translation: AAI04770.1.
AF037447 mRNA. Translation: AAF13027.1.
AL356893 mRNA. Translation: CAB92850.1. Different initiation.
RefSeqNP_001129610.1. NM_001136138.2.
NP_001274147.1. NM_001287218.1.
NP_001274148.1. NM_001287219.1.
NP_001274149.1. NM_001287220.1.
NP_001274150.1. NM_001287221.1.
NP_036556.2. NM_012424.4.
UniGeneHs.591416.

3D structure databases

ProteinModelPortalQ96S38.
SMRQ96S38. Positions 799-1066.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117810. 4 interactions.
IntActQ96S38. 4 interactions.
MINTMINT-1036906.
STRING9606.ENSP00000355927.

Chemistry

ChEMBLCHEMBL1795193.

PTM databases

PhosphoSiteQ96S38.

Polymorphism databases

DMDM94717650.

Proteomic databases

PaxDbQ96S38.
PRIDEQ96S38.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000366959; ENSP00000355926; ENSG00000136643. [Q96S38-2]
ENST00000366960; ENSP00000355927; ENSG00000136643. [Q96S38-1]
GeneID26750.
KEGGhsa:26750.
UCSCuc001hke.3. human. [Q96S38-1]

Organism-specific databases

CTD26750.
GeneCardsGC01P213224.
HGNCHGNC:10439. RPS6KC1.
HPAHPA026531.
HPA031565.
neXtProtNX_Q96S38.
PharmGKBPA34854.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000049101.
HOVERGENHBG078266.
InParanoidQ96S38.
OMAVPNMVCL.
OrthoDBEOG78PV8C.
PhylomeDBQ96S38.
TreeFamTF323964.

Enzyme and pathway databases

SignaLinkQ96S38.

Gene expression databases

ArrayExpressQ96S38.
BgeeQ96S38.
CleanExHS_RPS6KC1.
GenevestigatorQ96S38.

Family and domain databases

Gene3D1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR007330. MIT.
IPR001683. Phox.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamPF04212. MIT. 1 hit.
PF00069. Pkinase. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTSM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMSSF116846. SSF116846. 1 hit.
SSF56112. SSF56112. 2 hits.
SSF64268. SSF64268. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRPS6KC1. human.
GeneWikiRPS6KC1.
GenomeRNAi26750.
NextBio49115.
PROQ96S38.

Entry information

Entry nameKS6C1_HUMAN
AccessionPrimary (citable) accession number: Q96S38
Secondary accession number(s): B1APS8 expand/collapse secondary AC list , B3KVM4, D3DTA4, Q8TDD3, Q9NSF4, Q9UL66
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM