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Q96S38

- KS6C1_HUMAN

UniProt

Q96S38 - KS6C1_HUMAN

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Protein

Ribosomal protein S6 kinase delta-1

Gene

RPS6KC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei820 – 8201ATPPROSITE-ProRule annotation
Active sitei929 – 9291Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi801 – 8099ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphatidylinositol binding Source: InterPro
  3. protein serine/threonine kinase activity Source: ProtInc

GO - Biological processi

  1. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96S38.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinase delta-1 (EC:2.7.11.1)
Short name:
S6K-delta-1
Alternative name(s):
52 kDa ribosomal protein S6 kinase
Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein
SPHK1-binding protein
Gene namesi
Name:RPS6KC1
Synonyms:RPK118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10439. RPS6KC1.

Subcellular locationi

Cytoplasm 1 Publication. Membrane 1 Publication
Note: Also found in some small dot-like or ring-shaped early endosome structures.

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. early endosome Source: UniProtKB
  3. intracellular membrane-bounded organelle Source: HPA
  4. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10661066Ribosomal protein S6 kinase delta-1PRO_0000233127Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei423 – 4231Phosphoserine1 Publication
Modified residuei427 – 4271Phosphoserine1 Publication
Modified residuei605 – 6051PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96S38.
PaxDbiQ96S38.
PRIDEiQ96S38.

PTM databases

PhosphoSiteiQ96S38.

Expressioni

Tissue specificityi

Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon.1 Publication

Gene expression databases

BgeeiQ96S38.
CleanExiHS_RPS6KC1.
ExpressionAtlasiQ96S38. baseline and differential.
GenevestigatoriQ96S38.

Organism-specific databases

HPAiHPA026531.
HPA031565.

Interactioni

Subunit structurei

Interacts with SPHK1 and phosphatidylinositol 3-phosphate.1 Publication

Protein-protein interaction databases

BioGridi117810. 4 interactions.
IntActiQ96S38. 4 interactions.
MINTiMINT-1036906.
STRINGi9606.ENSP00000355927.

Structurei

3D structure databases

ProteinModelPortaliQ96S38.
SMRiQ96S38. Positions 799-1066.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 132125PXPROSITE-ProRule annotationAdd
BLAST
Domaini277 – 30529MITAdd
BLAST
Domaini344 – 445102Protein kinase 1PROSITE-ProRule annotationAdd
BLAST
Domaini794 – 1056263Protein kinase 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.PROSITE-ProRule annotation
Contains 1 MIT domain.Curated
Contains 2 protein kinase domains.PROSITE-ProRule annotation
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00530000063268.
HOGENOMiHOG000049101.
HOVERGENiHBG078266.
InParanoidiQ96S38.
OMAiVPNMVCL.
OrthoDBiEOG78PV8C.
PhylomeDBiQ96S38.
TreeFamiTF323964.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR007330. MIT.
IPR001683. Phox.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00069. Pkinase. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF56112. SSF56112. 2 hits.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96S38-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSYRERSAD LARFYTVTEP QRHPRGYTVY KVTARVVSRR NPEDVQEIIV
60 70 80 90 100
WKRYSDFKKL HKELWQIHKN LFRHSELFPP FAKGIVFGRF DETVIEERRQ
110 120 130 140 150
CAEDLLQFSA NIPALYNSKQ LEDFFKGGII NDSSELIGPA EAHSDSLIDT
160 170 180 190 200
FPECSTEGFS SDSDLVSLTV DVDSLAELDD GMASNQNSPI RTFGLNLSSD
210 220 230 240 250
SSALGAVASD SEQSKTEEER ESRSLFPGSL KPKLGKRDYL EKAGELIKLA
260 270 280 290 300
LKKEEEDDYE AASDFYRKGV DLLLEGVQGE SSPTRREAVK RRTAEYLMRA
310 320 330 340 350
ESISSLYGKP QLDDVSQPPG SLSSRPLWNL RSPAEELKAF RVLGVIDKVL
360 370 380 390 400
LVMDTRTEQT FILKGLRKSS EYSRNRKTII PRCVPNMVCL HKYIISEESV
410 420 430 440 450
FLVLQHAEGG KLWSYISKFL NRSPEESFDI KEVKKPTLAK VHLQQPTSSP
460 470 480 490 500
QDSSSFESRG SDGGSMLKAL PLKSSLTPSS QDDSNQEDDG QDSSPKWPDS
510 520 530 540 550
GSSSEEECTT SYLTLCNEYG QEKIEPGSLN EEPFMKTEGN GVDTKAIKSF
560 570 580 590 600
PAHLAADSDS PSTQLRAHEL KFFPNDDPEA VSSPRTSDSL SRSKNSPMEF
610 620 630 640 650
FRIDSKDSAS ELLGLDFGEK LYSLKSEPLK PFFTLPDGDS ASRSFNTSES
660 670 680 690 700
KVEFKAQDTI SRGSDDSVPV ISFKDAAFDD VSGTDEGRPD LLVNLPGELE
710 720 730 740 750
STREAAAMGP TKFTQTNIGI IENKLLEAPD VLCLRLSTEQ CQAHEEKGIE
760 770 780 790 800
ELSDPSGPKS YSITEKHYAQ EDPRMLFVAA VDHSSSGDMS LLPSSDPKFQ
810 820 830 840 850
GLGVVESAVT ANNTEESLFR ICSPLSGANE YIASTDTLKT EEVLLFTDQT
860 870 880 890 900
DDLAKEEPTS LFQRDSETKG ESGLVLEGDK EIHQIFEDLD KKLALASRFY
910 920 930 940 950
IPEGCIQRWA AEMVVALDAL HREGIVCRDL NPNNILLNDR GHIQLTYFSR
960 970 980 990 1000
WSEVEDSCDS DAIERMYCAP EVGAITEETE ACDWWSLGAV LFELLTGKTL
1010 1020 1030 1040 1050
VECHPAGINT HTTLNMPECV SEEARSLIQQ LLQFNPLERL GAGVAGVEDI
1060
KSHPFFTPVD WAELMR
Length:1,066
Mass (Da):118,682
Last modified:May 2, 2006 - v2
Checksum:i670EE5965F3B8274
GO
Isoform 2 (identifier: Q96S38-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-47: Missing.

Note: No experimental confirmation available.

Show »
Length:1,054
Mass (Da):117,273
Checksum:iF514E37BF7CCC4F0
GO

Sequence cautioni

The sequence CAB92850.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351R → G in BAB63956. (PubMed:12077123)Curated
Sequence conflicti250 – 2501A → V in BAB63956. (PubMed:12077123)Curated
Sequence conflicti1065 – 10651Missing(PubMed:10552933)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421P → T.1 Publication
Corresponds to variant rs56087470 [ dbSNP | Ensembl ].
VAR_040647
Natural varianti96 – 961E → K.1 Publication
Corresponds to variant rs56032860 [ dbSNP | Ensembl ].
VAR_040648
Natural varianti319 – 3191P → L.1 Publication
Corresponds to variant rs56369827 [ dbSNP | Ensembl ].
VAR_040649
Natural varianti424 – 4241P → L.1 Publication
Corresponds to variant rs56183862 [ dbSNP | Ensembl ].
VAR_040650
Natural varianti546 – 5461A → P.1 Publication
Corresponds to variant rs35281247 [ dbSNP | Ensembl ].
VAR_040651
Natural varianti554 – 5541L → I in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication
VAR_040652
Natural varianti561 – 5611P → R.
Corresponds to variant rs17020314 [ dbSNP | Ensembl ].
VAR_051635
Natural varianti575 – 5751N → S.1 Publication
Corresponds to variant rs56060894 [ dbSNP | Ensembl ].
VAR_040653
Natural varianti663 – 6631G → A in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
VAR_040654
Natural varianti853 – 8531L → F.1 Publication
Corresponds to variant rs34080597 [ dbSNP | Ensembl ].
VAR_040655
Natural varianti1003 – 10031C → Y in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040656
Natural varianti1022 – 10221E → K in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication
VAR_040657

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei36 – 4712Missing in isoform 2. 1 PublicationVSP_046333Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB070706 mRNA. Translation: BAB63956.1.
AF477978 mRNA. Translation: AAL84818.1.
AK122921 mRNA. No translation available.
AK122989 mRNA. Translation: BAG53836.1.
AL645860, AL512449, AL583826 Genomic DNA. Translation: CAH70703.1.
AL645860, AL512449, AL583826 Genomic DNA. Translation: CAH70704.1.
AL512449, AL583826, AL645860 Genomic DNA. Translation: CAH71999.1.
AL512449, AL583826, AL645860 Genomic DNA. Translation: CAH72000.1.
AL583826, AL512449, AL645860 Genomic DNA. Translation: CAH73804.1.
AL583826, AL512449, AL645860 Genomic DNA. Translation: CAH73805.1.
CH471100 Genomic DNA. Translation: EAW93362.1.
CH471100 Genomic DNA. Translation: EAW93363.1.
BC104769 mRNA. Translation: AAI04770.1.
AF037447 mRNA. Translation: AAF13027.1.
AL356893 mRNA. Translation: CAB92850.1. Different initiation.
CCDSiCCDS1513.1. [Q96S38-1]
CCDS44317.1. [Q96S38-2]
RefSeqiNP_001129610.1. NM_001136138.2. [Q96S38-2]
NP_001274147.1. NM_001287218.1.
NP_001274148.1. NM_001287219.1.
NP_001274149.1. NM_001287220.1.
NP_001274150.1. NM_001287221.1.
NP_036556.2. NM_012424.4. [Q96S38-1]
UniGeneiHs.591416.

Genome annotation databases

EnsembliENST00000366959; ENSP00000355926; ENSG00000136643. [Q96S38-2]
ENST00000366960; ENSP00000355927; ENSG00000136643. [Q96S38-1]
GeneIDi26750.
KEGGihsa:26750.
UCSCiuc001hke.3. human. [Q96S38-1]

Polymorphism databases

DMDMi94717650.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB070706 mRNA. Translation: BAB63956.1 .
AF477978 mRNA. Translation: AAL84818.1 .
AK122921 mRNA. No translation available.
AK122989 mRNA. Translation: BAG53836.1 .
AL645860 , AL512449 , AL583826 Genomic DNA. Translation: CAH70703.1 .
AL645860 , AL512449 , AL583826 Genomic DNA. Translation: CAH70704.1 .
AL512449 , AL583826 , AL645860 Genomic DNA. Translation: CAH71999.1 .
AL512449 , AL583826 , AL645860 Genomic DNA. Translation: CAH72000.1 .
AL583826 , AL512449 , AL645860 Genomic DNA. Translation: CAH73804.1 .
AL583826 , AL512449 , AL645860 Genomic DNA. Translation: CAH73805.1 .
CH471100 Genomic DNA. Translation: EAW93362.1 .
CH471100 Genomic DNA. Translation: EAW93363.1 .
BC104769 mRNA. Translation: AAI04770.1 .
AF037447 mRNA. Translation: AAF13027.1 .
AL356893 mRNA. Translation: CAB92850.1 . Different initiation.
CCDSi CCDS1513.1. [Q96S38-1 ]
CCDS44317.1. [Q96S38-2 ]
RefSeqi NP_001129610.1. NM_001136138.2. [Q96S38-2 ]
NP_001274147.1. NM_001287218.1.
NP_001274148.1. NM_001287219.1.
NP_001274149.1. NM_001287220.1.
NP_001274150.1. NM_001287221.1.
NP_036556.2. NM_012424.4. [Q96S38-1 ]
UniGenei Hs.591416.

3D structure databases

ProteinModelPortali Q96S38.
SMRi Q96S38. Positions 799-1066.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117810. 4 interactions.
IntActi Q96S38. 4 interactions.
MINTi MINT-1036906.
STRINGi 9606.ENSP00000355927.

Chemistry

ChEMBLi CHEMBL1795193.

PTM databases

PhosphoSitei Q96S38.

Polymorphism databases

DMDMi 94717650.

Proteomic databases

MaxQBi Q96S38.
PaxDbi Q96S38.
PRIDEi Q96S38.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366959 ; ENSP00000355926 ; ENSG00000136643 . [Q96S38-2 ]
ENST00000366960 ; ENSP00000355927 ; ENSG00000136643 . [Q96S38-1 ]
GeneIDi 26750.
KEGGi hsa:26750.
UCSCi uc001hke.3. human. [Q96S38-1 ]

Organism-specific databases

CTDi 26750.
GeneCardsi GC01P213224.
HGNCi HGNC:10439. RPS6KC1.
HPAi HPA026531.
HPA031565.
neXtProti NX_Q96S38.
PharmGKBi PA34854.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00530000063268.
HOGENOMi HOG000049101.
HOVERGENi HBG078266.
InParanoidi Q96S38.
OMAi VPNMVCL.
OrthoDBi EOG78PV8C.
PhylomeDBi Q96S38.
TreeFami TF323964.

Enzyme and pathway databases

SignaLinki Q96S38.

Miscellaneous databases

ChiTaRSi RPS6KC1. human.
GeneWikii RPS6KC1.
GenomeRNAii 26750.
NextBioi 49115.
PROi Q96S38.

Gene expression databases

Bgeei Q96S38.
CleanExi HS_RPS6KC1.
ExpressionAtlasi Q96S38. baseline and differential.
Genevestigatori Q96S38.

Family and domain databases

Gene3Di 1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR007330. MIT.
IPR001683. Phox.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF04212. MIT. 1 hit.
PF00069. Pkinase. 1 hit.
PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF116846. SSF116846. 1 hit.
SSF56112. SSF56112. 2 hits.
SSF64268. SSF64268. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein."
    Hayashi S., Okada T., Igarashi N., Fujita T., Jahangeer S., Nakamura S.
    J. Biol. Chem. 277:33319-33324(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH SPHK1 AND PHOSPHATIDYLINOSITOL 3-PHOSPHATE, SUBCELLULAR LOCATION.
  2. Guo J.H., Yu L.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Testis.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1."
    Zhang H., Yu L., Mao N., Fu Q., Tu Q., Gao J., Zhao S.
    Genomics 61:314-318(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 598-1066 (ISOFORM 1).
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 683-1066 (ISOFORM 1).
    Tissue: Amygdala.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND SER-427, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-42; LYS-96; LEU-319; LEU-424; PRO-546; ILE-554; SER-575; ALA-663; PHE-853; TYR-1003 AND LYS-1022.

Entry informationi

Entry nameiKS6C1_HUMAN
AccessioniPrimary (citable) accession number: Q96S38
Secondary accession number(s): B1APS8
, B3KVM4, D3DTA4, Q8TDD3, Q9NSF4, Q9UL66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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