Q96S38 (KS6C1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal protein S6 kinase delta-1
Short name=S6K-delta-1
EC=2.7.11.1

Alternative name(s):
52 kDa ribosomal protein S6 kinase
Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein
SPHK1-binding protein

Gene names

Name:	RPS6KC1
Synonyms:	RPK118

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1066 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Interacts with SPHK1 and phosphatidylinositol 3-phosphate. Ref.1
Subcellular location	Cytoplasm. Membrane. Note: Also found in some small dot-like or ring-shaped early endosome structures. Ref.1
Tissue specificity	Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon. Ref.1
Domain	The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily. Contains 1 MIT domain. Contains 2 protein kinase domains. Contains 1 PX (phox homology) domain.
Caution	Instead of Lys-820, Arg-820 is found at the binding site.
Sequence caution	The sequence CAB92850.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Traceable author statement Ref.7. Source: ProtInc
Cellular_component	early endosome Inferred from direct assay PubMed 15750338. Source: UniProtKB membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylinositol binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Traceable author statement Ref.7. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96S38-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96S38-2)

The sequence of this isoform differs from the canonical sequence as follows:
     36-47: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1066	1066	Ribosomal protein S6 kinase delta-1		PRO_0000233127
Regions
	Domain	8 – 132	125	PX
	Domain	277 – 305	29	MIT
	Domain	344 – 445	102	Protein kinase 1
	Domain	794 – 1056	263	Protein kinase 2
	Nucleotide binding	801 – 809	9	ATP By similarity
Sites
	Active site	929	1	Proton acceptor By similarity
	Binding site	820	1	ATP By similarity
Amino acid modifications
	Modified residue	423	1	Phosphoserine Ref.12
	Modified residue	427	1	Phosphoserine Ref.12
	Modified residue	583	1	Phosphoserine By similarity
	Modified residue	640	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	36 – 47	12	Missing in isoform 2.		VSP_046333
	Natural variant	42	1	P → T. Ref.13 Corresponds to variant rs56087470 [ dbSNP | Ensembl ].		VAR_040647
	Natural variant	96	1	E → K. Ref.13 Corresponds to variant rs56032860 [ dbSNP | Ensembl ].		VAR_040648
	Natural variant	319	1	P → L. Ref.13 Corresponds to variant rs56369827 [ dbSNP | Ensembl ].		VAR_040649
	Natural variant	424	1	P → L. Ref.13 Corresponds to variant rs56183862 [ dbSNP | Ensembl ].		VAR_040650
	Natural variant	546	1	A → P. Ref.13 Corresponds to variant rs35281247 [ dbSNP | Ensembl ].		VAR_040651
	Natural variant	554	1	L → I in a lung neuroendocrine carcinoma sample; somatic mutation. Ref.13		VAR_040652
	Natural variant	561	1	P → R. Corresponds to variant rs17020314 [ dbSNP | Ensembl ].		VAR_051635
	Natural variant	575	1	N → S. Ref.13 Corresponds to variant rs56060894 [ dbSNP | Ensembl ].		VAR_040653
	Natural variant	663	1	G → A in an ovarian mucinous carcinoma sample; somatic mutation. Ref.13		VAR_040654
	Natural variant	853	1	L → F. Ref.13 Corresponds to variant rs34080597 [ dbSNP | Ensembl ].		VAR_040655
	Natural variant	1003	1	C → Y in a lung adenocarcinoma sample; somatic mutation. Ref.13		VAR_040656
	Natural variant	1022	1	E → K in a breast infiltrating ductal carcinoma sample; somatic mutation. Ref.13		VAR_040657
Experimental info
	Sequence conflict	35	1	R → G in BAB63956. Ref.1
	Sequence conflict	250	1	A → V in BAB63956. Ref.1
	Sequence conflict	1065	1	Missing Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 2, 2006. Version 2. Checksum: 670EE5965F3B8274	FASTA	1,066	118,682
	10 20 30 40 50 60 MTSYRERSAD LARFYTVTEP QRHPRGYTVY KVTARVVSRR NPEDVQEIIV WKRYSDFKKL 70 80 90 100 110 120 HKELWQIHKN LFRHSELFPP FAKGIVFGRF DETVIEERRQ CAEDLLQFSA NIPALYNSKQ 130 140 150 160 170 180 LEDFFKGGII NDSSELIGPA EAHSDSLIDT FPECSTEGFS SDSDLVSLTV DVDSLAELDD 190 200 210 220 230 240 GMASNQNSPI RTFGLNLSSD SSALGAVASD SEQSKTEEER ESRSLFPGSL KPKLGKRDYL 250 260 270 280 290 300 EKAGELIKLA LKKEEEDDYE AASDFYRKGV DLLLEGVQGE SSPTRREAVK RRTAEYLMRA 310 320 330 340 350 360 ESISSLYGKP QLDDVSQPPG SLSSRPLWNL RSPAEELKAF RVLGVIDKVL LVMDTRTEQT 370 380 390 400 410 420 FILKGLRKSS EYSRNRKTII PRCVPNMVCL HKYIISEESV FLVLQHAEGG KLWSYISKFL 430 440 450 460 470 480 NRSPEESFDI KEVKKPTLAK VHLQQPTSSP QDSSSFESRG SDGGSMLKAL PLKSSLTPSS 490 500 510 520 530 540 QDDSNQEDDG QDSSPKWPDS GSSSEEECTT SYLTLCNEYG QEKIEPGSLN EEPFMKTEGN 550 560 570 580 590 600 GVDTKAIKSF PAHLAADSDS PSTQLRAHEL KFFPNDDPEA VSSPRTSDSL SRSKNSPMEF 610 620 630 640 650 660 FRIDSKDSAS ELLGLDFGEK LYSLKSEPLK PFFTLPDGDS ASRSFNTSES KVEFKAQDTI 670 680 690 700 710 720 SRGSDDSVPV ISFKDAAFDD VSGTDEGRPD LLVNLPGELE STREAAAMGP TKFTQTNIGI 730 740 750 760 770 780 IENKLLEAPD VLCLRLSTEQ CQAHEEKGIE ELSDPSGPKS YSITEKHYAQ EDPRMLFVAA 790 800 810 820 830 840 VDHSSSGDMS LLPSSDPKFQ GLGVVESAVT ANNTEESLFR ICSPLSGANE YIASTDTLKT 850 860 870 880 890 900 EEVLLFTDQT DDLAKEEPTS LFQRDSETKG ESGLVLEGDK EIHQIFEDLD KKLALASRFY 910 920 930 940 950 960 IPEGCIQRWA AEMVVALDAL HREGIVCRDL NPNNILLNDR GHIQLTYFSR WSEVEDSCDS 970 980 990 1000 1010 1020 DAIERMYCAP EVGAITEETE ACDWWSLGAV LFELLTGKTL VECHPAGINT HTTLNMPECV 1030 1040 1050 1060 SEEARSLIQQ LLQFNPLERL GAGVAGVEDI KSHPFFTPVD WAELMR
	Isoform 2 [UniParc]. Checksum: F514E37BF7CCC4F0	FASTA	1,054	117,273
	10 20 30 40 50 60 MTSYRERSAD LARFYTVTEP QRHPRGYTVY KVTARIIVWK RYSDFKKLHK ELWQIHKNLF 70 80 90 100 110 120 RHSELFPPFA KGIVFGRFDE TVIEERRQCA EDLLQFSANI PALYNSKQLE DFFKGGIIND 130 140 150 160 170 180 SSELIGPAEA HSDSLIDTFP ECSTEGFSSD SDLVSLTVDV DSLAELDDGM ASNQNSPIRT 190 200 210 220 230 240 FGLNLSSDSS ALGAVASDSE QSKTEEERES RSLFPGSLKP KLGKRDYLEK AGELIKLALK 250 260 270 280 290 300 KEEEDDYEAA SDFYRKGVDL LLEGVQGESS PTRREAVKRR TAEYLMRAES ISSLYGKPQL 310 320 330 340 350 360 DDVSQPPGSL SSRPLWNLRS PAEELKAFRV LGVIDKVLLV MDTRTEQTFI LKGLRKSSEY 370 380 390 400 410 420 SRNRKTIIPR CVPNMVCLHK YIISEESVFL VLQHAEGGKL WSYISKFLNR SPEESFDIKE 430 440 450 460 470 480 VKKPTLAKVH LQQPTSSPQD SSSFESRGSD GGSMLKALPL KSSLTPSSQD DSNQEDDGQD 490 500 510 520 530 540 SSPKWPDSGS SSEEECTTSY LTLCNEYGQE KIEPGSLNEE PFMKTEGNGV DTKAIKSFPA 550 560 570 580 590 600 HLAADSDSPS TQLRAHELKF FPNDDPEAVS SPRTSDSLSR SKNSPMEFFR IDSKDSASEL 610 620 630 640 650 660 LGLDFGEKLY SLKSEPLKPF FTLPDGDSAS RSFNTSESKV EFKAQDTISR GSDDSVPVIS 670 680 690 700 710 720 FKDAAFDDVS GTDEGRPDLL VNLPGELEST REAAAMGPTK FTQTNIGIIE NKLLEAPDVL 730 740 750 760 770 780 CLRLSTEQCQ AHEEKGIEEL SDPSGPKSYS ITEKHYAQED PRMLFVAAVD HSSSGDMSLL 790 800 810 820 830 840 PSSDPKFQGL GVVESAVTAN NTEESLFRIC SPLSGANEYI ASTDTLKTEE VLLFTDQTDD 850 860 870 880 890 900 LAKEEPTSLF QRDSETKGES GLVLEGDKEI HQIFEDLDKK LALASRFYIP EGCIQRWAAE 910 920 930 940 950 960 MVVALDALHR EGIVCRDLNP NNILLNDRGH IQLTYFSRWS EVEDSCDSDA IERMYCAPEV 970 980 990 1000 1010 1020 GAITEETEAC DWWSLGAVLF ELLTGKTLVE CHPAGINTHT TLNMPECVSE EARSLIQQLL 1030 1040 1050 QFNPLERLGA GVAGVEDIKS HPFFTPVDWA ELMR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein." Hayashi S., Okada T., Igarashi N., Fujita T., Jahangeer S., Nakamura S. J. Biol. Chem. 277:33319-33324(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH SPHK1 AND PHOSPHATIDYLINOSITOL 3-PHOSPHATE, SUBCELLULAR LOCATION.
[2]	Guo J.H., Yu L. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Testis.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Tissue: Brain.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[7]	"Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1." Zhang H., Yu L., Mao N., Fu Q., Tu Q., Gao J., Zhao S. Genomics 61:314-318(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 598-1066 (ISOFORM 1).
[8]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 683-1066 (ISOFORM 1). Tissue: Amygdala.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND SER-427, MASS SPECTROMETRY.
[13]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-42; LYS-96; LEU-319; LEU-424; PRO-546; ILE-554; SER-575; ALA-663; PHE-853; TYR-1003 AND LYS-1022.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB070706 mRNA. Translation: BAB63956.1. AF477978 mRNA. Translation: AAL84818.1. AK122921 mRNA. No translation available. AK122989 mRNA. Translation: BAG53836.1. AL645860, AL512449, AL583826 Genomic DNA. Translation: CAH70703.1. AL645860, AL512449, AL583826 Genomic DNA. Translation: CAH70704.1. AL512449, AL583826, AL645860 Genomic DNA. Translation: CAH71999.1. AL512449, AL583826, AL645860 Genomic DNA. Translation: CAH72000.1. AL583826, AL512449, AL645860 Genomic DNA. Translation: CAH73804.1. AL583826, AL512449, AL645860 Genomic DNA. Translation: CAH73805.1. CH471100 Genomic DNA. Translation: EAW93362.1. CH471100 Genomic DNA. Translation: EAW93363.1. BC104769 mRNA. Translation: AAI04770.1. AF037447 mRNA. Translation: AAF13027.1. AL356893 mRNA. Translation: CAB92850.1. Different initiation.
IPI	IPI00291351. IPI00644021.
RefSeq	NP_001129610.1. NM_001136138.1. NP_036556.2. NM_012424.3.
UniGene	Hs.591416.
3D structure databases
ProteinModelPortal	Q96S38.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96S38. 4 interactions.
MINT	MINT-1036906.
STRING	9606.ENSP00000355927.
PTM databases
PhosphoSite	Q96S38.
Polymorphism databases
DMDM	94717650.
Proteomic databases
PaxDb	Q96S38.
PRIDE	Q96S38.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000366959; ENSP00000355926; ENSG00000136643. ENST00000366960; ENSP00000355927; ENSG00000136643.
GeneID	26750.
KEGG	hsa:26750.
UCSC	uc001hke.3. human.
Organism-specific databases
CTD	26750.
GeneCards	GC01P213224.
HGNC	HGNC:10439. RPS6KC1.
HPA	HPA026531.
neXtProt	NX_Q96S38.
PharmGKB	PA34854.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000049101.
HOVERGEN	HBG078266.
InParanoid	Q96S38.
OMA	KVHLQQP.
OrthoDB	EOG4TXBR9.
PhylomeDB	Q96S38.
Gene expression databases
ArrayExpress	Q96S38.
Bgee	Q96S38.
CleanEx	HS_RPS6KC1.
Genevestigator	Q96S38.
GermOnline	ENSG00000136643. Homo sapiens.
Family and domain databases
Gene3D	3.30.1520.10. 1 hit.
InterPro	IPR011009. Kinase-like_dom. IPR007330. MIT. IPR001683. Phox. IPR000719. Prot_kinase_cat_dom. [Graphical view]
Pfam	PF04212. MIT. 1 hit. PF00069. Pkinase. 1 hit. PF00787. PX. 1 hit. [Graphical view]
SMART	SM00745. MIT. 1 hit. SM00312. PX. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF64268. PX. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. False negative. PS50195. PX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1795193.
ChiTaRS	RPS6KC1. human.
GenomeRNAi	26750.
NextBio	49115.

Entry information

Entry name

KS6C1_HUMAN

Accession

Primary (citable) accession number: Q96S38
Secondary accession number(s): B1APS8 , B3KVM4, D3DTA4, Q8TDD3, Q9NSF4, Q9UL66

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	May 2, 2006
Last modified:	May 1, 2013
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.