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Protein

Methyltransferase-like 26

Gene

METTL26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like 26Imported
Gene namesi
Name:METTL26Imported
Synonyms:JFP2
ORF Names:C16orf13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000130731.15.
HGNCiHGNC:14141. METTL26.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130731.
PharmGKBiPA25526.

Polymorphism and mutation databases

DMDMi189082900.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003371141 – 204Methyltransferase-like 26Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei149PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96S19.
MaxQBiQ96S19.
PaxDbiQ96S19.
PeptideAtlasiQ96S19.
PRIDEiQ96S19.

PTM databases

iPTMnetiQ96S19.
PhosphoSitePlusiQ96S19.

Expressioni

Gene expression databases

BgeeiENSG00000130731.
CleanExiHS_C16orf13.
ExpressionAtlasiQ96S19. baseline and differential.
GenevisibleiQ96S19. HS.

Organism-specific databases

HPAiHPA044004.

Interactioni

Protein-protein interaction databases

BioGridi124050. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ96S19.
SMRiQ96S19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0585 family.Curated

Phylogenomic databases

eggNOGiENOG410IW6B. Eukaryota.
ENOG4111J4H. LUCA.
GeneTreeiENSGT00390000010750.
HOGENOMiHOG000171462.
HOVERGENiHBG060382.
InParanoidiQ96S19.
OMAiMPANNFS.
OrthoDBiEOG091G0NOM.
PhylomeDBiQ96S19.
TreeFamiTF315025.

Family and domain databases

InterProiView protein in InterPro
IPR010342. DUF938.
IPR029063. SAM-dependent_MTases.
PANTHERiPTHR20974. PTHR20974. 1 hit.
PfamiView protein in Pfam
PF06080. DUF938. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96S19-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLVAAAAERN KDPILHVLRQ YLDPAQRGVR VLEVASGSGQ HAAHFARAFP
60 70 80 90 100
LAEWQPSDVD QRCLDSIAAT TQAQGLTNVK APLHLDVTWG WEHWGGILPQ
110 120 130 140 150
SLDLLLCINM AHVSPLRCTE GLFRAAGHLL KPRALLITYG PYAINGKISP
160 170 180 190 200
QSNVDFDLML RCRNPEWGLR DTALLEDLGK ASGLLLERMV DMPANNKCLI

FRKN
Length:204
Mass (Da):22,578
Last modified:May 20, 2008 - v2
Checksum:iD927CBB1151FC753
GO
Isoform 2 (identifier: Q96S19-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-204: SIAATTQAQG...NNKCLIFRKN → RCGPRGGHFY...PLLNVPPSLP

Show »
Length:147
Mass (Da):15,015
Checksum:iD8E32F57B9CC396F
GO
Isoform 3 (identifier: Q96S19-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-162: Missing.

Note: No experimental confirmation available.
Show »
Length:107
Mass (Da):11,975
Checksum:i03AC55C1AAC3853B
GO
Isoform 4 (identifier: Q96S19-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-204: PYAINGKISP...NNKCLIFRKN → EPRMGASGHS...RLCEARTLPP

Note: No experimental confirmation available.Curated
Show »
Length:205
Mass (Da):22,158
Checksum:iD4E8BCCA2C040CFE
GO
Isoform 5 (identifier: Q96S19-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-163: SIAATTQAQG...VDFDLMLRCR → RGSSEQQDTCSNPGPCSSPTG

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:127
Mass (Da):13,896
Checksum:iDEDCC69D97E26C41
GO
Isoform 6 (identifier: Q96S19-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-204: GLFRAAGHLL...NNKCLIFRKN → EPRMGASGHS...RLCEARTLPP

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:185
Mass (Da):20,009
Checksum:iFB66FF846FBB73A6
GO

Sequence cautioni

The sequence AAK61238 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAW85785 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 4 (identifier: Q96S19-4)
Sequence conflicti196R → G in BAG58505 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064368136L → P1 PublicationCorresponds to variant dbSNP:rs865791888Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03391866 – 204SIAAT…IFRKN → RCGPRGGHFYRCGGPGPQEP TARSPGGKGCGSGSEGAGWE PGGAPGAGPSCAAPAAAEVG GPRGPPSQPLWSPLLNVPPS LP in isoform 2. 2 PublicationsAdd BLAST139
Alternative sequenceiVSP_04683866 – 163SIAAT…MLRCR → RGSSEQQDTCSNPGPCSSPT G in isoform 5. CuratedAdd BLAST98
Alternative sequenceiVSP_03391966 – 162Missing in isoform 3. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_046839121 – 204GLFRA…IFRKN → EPRMGASGHSPPGGPGKGQW PAPGEDGGHASQQQMPDLPE KLSPSFTPAHLHPCRRLCEA RTLPP in isoform 6. CuratedAdd BLAST84
Alternative sequenceiVSP_045804141 – 204PYAIN…IFRKN → EPRMGASGHSPPGGPGKGQW PAPGEDGGHASQQQMPDLPE KLSPSFTPAHLHPCRRLCEA RTLPP in isoform 4. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057077 mRNA. Translation: BAB71362.1.
AK293046 mRNA. Translation: BAF85735.1.
AK294482 mRNA. Translation: BAG57706.1.
AK295628 mRNA. Translation: BAG58505.1.
AE006464 Genomic DNA. Translation: AAK61238.1. Sequence problems.
Z84479 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85787.1.
CH471112 Genomic DNA. Translation: EAW85785.1. Sequence problems.
CH471112 Genomic DNA. Translation: EAW85786.1.
CH471112 Genomic DNA. Translation: EAW85788.1.
BC007207 mRNA. Translation: AAH07207.1.
BC047118 mRNA. Translation: AAH47118.1.
CCDSiCCDS32352.1. [Q96S19-3]
CCDS42090.1. [Q96S19-6]
CCDS42091.1. [Q96S19-4]
CCDS45367.1. [Q96S19-5]
CCDS45368.1. [Q96S19-1]
RefSeqiNP_001035250.1. NM_001040160.2. [Q96S19-4]
NP_001035251.1. NM_001040161.2. [Q96S19-3]
NP_001035252.1. NM_001040162.2. [Q96S19-5]
NP_001035255.1. NM_001040165.2. [Q96S19-6]
NP_115742.3. NM_032366.4. [Q96S19-1]
UniGeneiHs.239500.

Genome annotation databases

EnsembliENST00000301686; ENSP00000445926; ENSG00000130731. [Q96S19-1]
ENST00000338401; ENSP00000444140; ENSG00000130731. [Q96S19-3]
ENST00000397664; ENSP00000440475; ENSG00000130731. [Q96S19-5]
ENST00000397665; ENSP00000444460; ENSG00000130731. [Q96S19-6]
ENST00000397666; ENSP00000440765; ENSG00000130731. [Q96S19-4]
GeneIDi84326.
KEGGihsa:84326.
UCSCiuc002chv.3. human. [Q96S19-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMTL26_HUMAN
AccessioniPrimary (citable) accession number: Q96S19
Secondary accession number(s): A8MTR1
, A8MWJ8, A8MZA1, B4DG95, B4DIJ3, D6REA6, F6TF62, F6VM53, Q96IW1, Q96MD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 27, 2017
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries