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Protein

JmjC domain-containing protein 8

Gene

JMJD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-50 is the initiator.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
JmjC domain-containing protein 8
Alternative name(s):
Jumonji domain-containing protein 8
Gene namesi
Name:JMJD8
Synonyms:C16orf20
ORF Names:PP14397
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000161999.11
HGNCiHGNC:14148 JMJD8
neXtProtiNX_Q96S16

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162392531

Polymorphism and mutation databases

DMDMi74717267

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003445311 – 334JmjC domain-containing protein 8Add BLAST334

Proteomic databases

EPDiQ96S16
PaxDbiQ96S16
PeptideAtlasiQ96S16
PRIDEiQ96S16

PTM databases

iPTMnetiQ96S16
PhosphoSitePlusiQ96S16

Expressioni

Gene expression databases

BgeeiENSG00000161999
CleanExiHS_JMJD8
ExpressionAtlasiQ96S16 baseline and differential
GenevisibleiQ96S16 HS

Interactioni

Protein-protein interaction databases

BioGridi130831, 17 interactors
STRINGi9606.ENSP00000399475

Structurei

3D structure databases

ProteinModelPortaliQ96S16
SMRiQ96S16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini201 – 334JmjCPROSITE-ProRule annotationAdd BLAST134

Phylogenomic databases

eggNOGiKOG2131 Eukaryota
ENOG410ZACM LUCA
HOVERGENiHBG108013
InParanoidiQ96S16
OrthoDBiEOG091G0I34
PhylomeDBiQ96S16
TreeFamiTF313408

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96S16-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVTGGAHSRS RGGLPSASRR GLFRGGPKEV TSGVRPGSRP LPRRRSCRPM
60 70 80 90 100
AGGWAQGSRR AARLPEGGRL MAPASRLLAL WALAAVALPG SGAEGDGGWR
110 120 130 140 150
PGGPGAVAEE ERCTVERRAD LTYAEFVQQY AFVRPVILQG LTDNSRFRAL
160 170 180 190 200
CSRDRLLASF GDRVVRLSTA NTYSYHKVDL PFQEYVEQLL HPQDPTSLGN
210 220 230 240 250
DTLYFFGDNN FTEWASLFRH YSPPPFGLLG TAPAYSFGIA GAGSGVPFHW
260 270 280 290 300
HGPGYSEVIY GRKRWFLYPP EKTPEFHPNK TTLAWLRDTY PALPPSARPL
310 320 330
ECTIRAGEVL YFPDRWWHAT LNLDTSVFIS TFLG
Length:334
Mass (Da):36,870
Last modified:December 1, 2001 - v1
Checksum:i7E993A8CAEE98BD7
GO
Isoform 2 (identifier: Q96S16-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-129: Missing.

Note: No experimental confirmation available.
Show »
Length:304
Mass (Da):33,552
Checksum:i5AA14AC3A41298BD
GO

Sequence cautioni

The sequence AAI37101 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI37102 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAQ15256 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228L → P in AAY82251 (Ref. 6) Curated1
Sequence conflicti277H → R in AAY82251 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034849100 – 129Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006464 Genomic DNA Translation: AAK61243.1
Z92544 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85754.1
CH471112 Genomic DNA Translation: EAW85755.1
BC073785 mRNA Translation: AAH73785.1
BC094850 mRNA Translation: AAH94850.1
BC137100 mRNA Translation: AAI37101.1 Different initiation.
BC137101 mRNA Translation: AAI37102.1 Different initiation.
AF370420 mRNA Translation: AAQ15256.1 Different initiation.
DQ074695 mRNA Translation: AAY82251.1
RefSeqiNP_001005920.2, NM_001005920.2
NP_001310847.1, NM_001323918.1
NP_001310848.1, NM_001323919.1
NP_001310851.1, NM_001323922.1
UniGeneiHs.533771

Genome annotation databases

EnsembliENST00000412368; ENSP00000399475; ENSG00000161999
ENST00000609261; ENSP00000477481; ENSG00000161999
GeneIDi339123
KEGGihsa:339123
UCSCiuc002ciw.2 human [Q96S16-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiJMJD8_HUMAN
AccessioniPrimary (citable) accession number: Q96S16
Secondary accession number(s): B2RNS7
, D3DU58, Q4PKE3, Q4VBY1, Q6GMW5, Q71RB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM

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