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Protein

JmjC domain-containing protein 8

Gene

JMJD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
JmjC domain-containing protein 8
Alternative name(s):
Jumonji domain-containing protein 8
Gene namesi
Name:JMJD8
Synonyms:C16orf20
ORF Names:PP14397
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14148. JMJD8.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162392531.

Polymorphism and mutation databases

DMDMi74717267.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334JmjC domain-containing protein 8PRO_0000344531Add
BLAST

Proteomic databases

PaxDbiQ96S16.
PRIDEiQ96S16.

PTM databases

iPTMnetiQ96S16.
PhosphoSiteiQ96S16.

Expressioni

Gene expression databases

BgeeiQ96S16.
CleanExiHS_JMJD8.
ExpressionAtlasiQ96S16. baseline and differential.
GenevisibleiQ96S16. HS.

Interactioni

Protein-protein interaction databases

BioGridi130831. 15 interactions.
STRINGi9606.ENSP00000399475.

Structurei

3D structure databases

ProteinModelPortaliQ96S16.
SMRiQ96S16. Positions 104-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini201 – 334134JmjCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 JmjC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2131. Eukaryota.
ENOG410ZACM. LUCA.
HOVERGENiHBG108013.
InParanoidiQ96S16.
OrthoDBiEOG7K3TM0.
PhylomeDBiQ96S16.
TreeFamiTF313408.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96S16-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVTGGAHSRS RGGLPSASRR GLFRGGPKEV TSGVRPGSRP LPRRRSCRPM
60 70 80 90 100
AGGWAQGSRR AARLPEGGRL MAPASRLLAL WALAAVALPG SGAEGDGGWR
110 120 130 140 150
PGGPGAVAEE ERCTVERRAD LTYAEFVQQY AFVRPVILQG LTDNSRFRAL
160 170 180 190 200
CSRDRLLASF GDRVVRLSTA NTYSYHKVDL PFQEYVEQLL HPQDPTSLGN
210 220 230 240 250
DTLYFFGDNN FTEWASLFRH YSPPPFGLLG TAPAYSFGIA GAGSGVPFHW
260 270 280 290 300
HGPGYSEVIY GRKRWFLYPP EKTPEFHPNK TTLAWLRDTY PALPPSARPL
310 320 330
ECTIRAGEVL YFPDRWWHAT LNLDTSVFIS TFLG
Length:334
Mass (Da):36,870
Last modified:December 1, 2001 - v1
Checksum:i7E993A8CAEE98BD7
GO
Isoform 2 (identifier: Q96S16-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-129: Missing.

Note: No experimental confirmation available.
Show »
Length:304
Mass (Da):33,552
Checksum:i5AA14AC3A41298BD
GO

Sequence cautioni

The sequence AAI37101.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI37102.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAQ15256.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti228 – 2281L → P in AAY82251 (Ref. 6) Curated
Sequence conflicti277 – 2771H → R in AAY82251 (Ref. 6) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei100 – 12930Missing in isoform 2. 1 PublicationVSP_034849Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006464 Genomic DNA. Translation: AAK61243.1.
Z92544 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85754.1.
CH471112 Genomic DNA. Translation: EAW85755.1.
BC073785 mRNA. Translation: AAH73785.1.
BC094850 mRNA. Translation: AAH94850.1.
BC137100 mRNA. Translation: AAI37101.1. Different initiation.
BC137101 mRNA. Translation: AAI37102.1. Different initiation.
AF370420 mRNA. Translation: AAQ15256.1. Different initiation.
DQ074695 mRNA. Translation: AAY82251.1.
RefSeqiNP_001005920.2. NM_001005920.2.
UniGeneiHs.533771.

Genome annotation databases

EnsembliENST00000412368; ENSP00000399475; ENSG00000161999.
ENST00000609261; ENSP00000477481; ENSG00000161999.
GeneIDi339123.
KEGGihsa:339123.
UCSCiuc002ciw.2. human. [Q96S16-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006464 Genomic DNA. Translation: AAK61243.1.
Z92544 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85754.1.
CH471112 Genomic DNA. Translation: EAW85755.1.
BC073785 mRNA. Translation: AAH73785.1.
BC094850 mRNA. Translation: AAH94850.1.
BC137100 mRNA. Translation: AAI37101.1. Different initiation.
BC137101 mRNA. Translation: AAI37102.1. Different initiation.
AF370420 mRNA. Translation: AAQ15256.1. Different initiation.
DQ074695 mRNA. Translation: AAY82251.1.
RefSeqiNP_001005920.2. NM_001005920.2.
UniGeneiHs.533771.

3D structure databases

ProteinModelPortaliQ96S16.
SMRiQ96S16. Positions 104-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130831. 15 interactions.
STRINGi9606.ENSP00000399475.

PTM databases

iPTMnetiQ96S16.
PhosphoSiteiQ96S16.

Polymorphism and mutation databases

DMDMi74717267.

Proteomic databases

PaxDbiQ96S16.
PRIDEiQ96S16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412368; ENSP00000399475; ENSG00000161999.
ENST00000609261; ENSP00000477481; ENSG00000161999.
GeneIDi339123.
KEGGihsa:339123.
UCSCiuc002ciw.2. human. [Q96S16-1]

Organism-specific databases

CTDi339123.
GeneCardsiJMJD8.
H-InvDBHIX0038557.
HGNCiHGNC:14148. JMJD8.
neXtProtiNX_Q96S16.
PharmGKBiPA162392531.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2131. Eukaryota.
ENOG410ZACM. LUCA.
HOVERGENiHBG108013.
InParanoidiQ96S16.
OrthoDBiEOG7K3TM0.
PhylomeDBiQ96S16.
TreeFamiTF313408.

Miscellaneous databases

GenomeRNAii339123.
PROiQ96S16.

Gene expression databases

BgeeiQ96S16.
CleanExiHS_JMJD8.
ExpressionAtlasiQ96S16. baseline and differential.
GenevisibleiQ96S16. HS.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-334 (ISOFORM 1).
    Tissue: Kidney and Uterus.
  5. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-334 (ISOFORM 1).
  6. Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Lin L., Yang S.
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-334 (ISOFORM 2).

Entry informationi

Entry nameiJMJD8_HUMAN
AccessioniPrimary (citable) accession number: Q96S16
Secondary accession number(s): B2RNS7
, D3DU58, Q4PKE3, Q4VBY1, Q6GMW5, Q71RB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-50 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.