SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q96S15

- WDR24_HUMAN

UniProt

Q96S15 - WDR24_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
WD repeat-containing protein 24
Gene
WDR24, C16orf21, JFP7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.

Enzyme and pathway databases

SignaLinkiQ96S15.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 24
Gene namesi
Name:WDR24
Synonyms:C16orf21
ORF Names:JFP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:20852. WDR24.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134918496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 920920WD repeat-containing protein 24
PRO_0000051375Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei724 – 7241Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96S15.
PaxDbiQ96S15.
PRIDEiQ96S15.

PTM databases

PhosphoSiteiQ96S15.

Expressioni

Gene expression databases

BgeeiQ96S15.
CleanExiHS_WDR24.
GenevestigatoriQ96S15.

Organism-specific databases

HPAiHPA039506.

Interactioni

Subunit structurei

Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers.1 Publication

Protein-protein interaction databases

BioGridi123953. 2 interactions.
IntActiQ96S15. 2 interactions.
MINTiMINT-1444376.
STRINGi9606.ENSP00000293883.

Structurei

3D structure databases

ProteinModelPortaliQ96S15.
SMRiQ96S15. Positions 141-453.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati134 – 17441WD 1
Add
BLAST
Repeati180 – 22041WD 2
Add
BLAST
Repeati291 – 33141WD 3
Add
BLAST
Repeati335 – 37541WD 4
Add
BLAST
Repeati379 – 42143WD 5
Add
BLAST
Repeati425 – 46844WD 6
Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat WDR24 family.
Contains 6 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000234392.
HOVERGENiHBG080644.
InParanoidiQ96S15.
OMAiSWFVDTA.
OrthoDBiEOG7DVD9Z.
PhylomeDBiQ96S15.
TreeFamiTF314190.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96S15-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGKKRTTSGE GRERQRLPAR RFRTTSPAAL RADSVDGGSL LAPLLGLTDR    50
AFSDCPDLAD GAMEKMSRVT TALGGSVLTG RTMHCHLDAP ANAISVCRDA 100
AQVVVAGRSI FKIYAIEEEQ FVEKLNLRVG RKPSLNLSCA DVVWHQMDEN 150
LLATAATNGV VVTWNLGRPS RNKQDQLFTE HKRTVNKVCF HPTEAHVLLS 200
GSQDGFMKCF DLRRKDSVST FSGEATEAGP REWAMAGCVP ILPVLSCRIL 250
RLHHSFAHGP MQDAESTAND ARESWGCPLY PLGLCSGPQA GQSESVRDVQ 300
FSIRDYFTFA STFENGNVQL WDIRRPDRCE RMFTAHNGPV FCCDWHPEDR 350
GWLATGGRDK MVKVWDMTTH RAKEMHCVQT IASVARVKWR PECRHHLATC 400
SMMVDHNIYV WDVRRPFVPA AMFEEHRDVT TGIAWRHPHD PSFLLSGSKD 450
SSLCQHLFRD ASQPVERANP EGLCYGLFGD LAFAAKESLV AAESGRKPYT 500
GDRRHPIFFK RKLDPAEPFA GLASSALSVF ETEPGGGGMR WFVDTAERYA 550
LAGRPLAELC DHNAKVAREL GRNQVAQTWT MLRIIYCSPG LVPTANLNHS 600
VGKGGSCGLP LMNSFNLKDM APGLGSETRL DRSKGDARSD TVLLDSSATL 650
ITNEDNEETE GSDVPADYLL GDVEGEEDEL YLLDPEHAHP EDPECVLPQE 700
AFPLRHEIVD TPPGPEHLQD KADSPHVSGS EADVASLAPV DSSFSLLSVS 750
HALYDSRLPP DFFGVLVRDM LHFYAEQGDV QMAVSVLIVL GERVRKDIDE 800
QTQEHWYTSY IDLLQRFRLW NVSNEVVKLS TSRAVSCLNQ ASTTLHVNCS 850
HCKRPMSSRG WVCDRCHRCA SMCAVCHHVV KGLFVWCQGC SHGGHLQHIM 900
KWLEGSSHCP AGCGHLCEYS 920
Length:920
Mass (Da):101,989
Last modified:December 1, 2001 - v1
Checksum:i3BE3989D72973714
GO
Isoform 2 (identifier: Q96S15-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     223-290: Missing.

Show »
Length:790
Mass (Da):88,207
Checksum:i6C109240F6251898
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6262Missing in isoform 2.
VSP_016180Add
BLAST
Alternative sequencei223 – 29068Missing in isoform 2.
VSP_016181Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006464 Genomic DNA. Translation: AAK61244.1.
AL136863 mRNA. Translation: CAB66797.1.
Z92544 Genomic DNA. Translation: CAM26347.1.
CH471112 Genomic DNA. Translation: EAW85752.1.
CH471112 Genomic DNA. Translation: EAW85753.1.
BC008025 mRNA. Translation: AAH08025.1.
BC009761 mRNA. Translation: AAH09761.2.
CCDSiCCDS10420.1. [Q96S15-2]
RefSeqiNP_115635.1. NM_032259.2. [Q96S15-2]
UniGeneiHs.459632.

Genome annotation databases

EnsembliENST00000248142; ENSP00000248142; ENSG00000127580. [Q96S15-1]
ENST00000293883; ENSP00000293883; ENSG00000127580. [Q96S15-2]
GeneIDi84219.
KEGGihsa:84219.
UCSCiuc002ciz.1. human. [Q96S15-2]

Polymorphism databases

DMDMi74762692.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006464 Genomic DNA. Translation: AAK61244.1 .
AL136863 mRNA. Translation: CAB66797.1 .
Z92544 Genomic DNA. Translation: CAM26347.1 .
CH471112 Genomic DNA. Translation: EAW85752.1 .
CH471112 Genomic DNA. Translation: EAW85753.1 .
BC008025 mRNA. Translation: AAH08025.1 .
BC009761 mRNA. Translation: AAH09761.2 .
CCDSi CCDS10420.1. [Q96S15-2 ]
RefSeqi NP_115635.1. NM_032259.2. [Q96S15-2 ]
UniGenei Hs.459632.

3D structure databases

ProteinModelPortali Q96S15.
SMRi Q96S15. Positions 141-453.
ModBasei Search...

Protein-protein interaction databases

BioGridi 123953. 2 interactions.
IntActi Q96S15. 2 interactions.
MINTi MINT-1444376.
STRINGi 9606.ENSP00000293883.

PTM databases

PhosphoSitei Q96S15.

Polymorphism databases

DMDMi 74762692.

Proteomic databases

MaxQBi Q96S15.
PaxDbi Q96S15.
PRIDEi Q96S15.

Protocols and materials databases

DNASUi 84219.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000248142 ; ENSP00000248142 ; ENSG00000127580 . [Q96S15-1 ]
ENST00000293883 ; ENSP00000293883 ; ENSG00000127580 . [Q96S15-2 ]
GeneIDi 84219.
KEGGi hsa:84219.
UCSCi uc002ciz.1. human. [Q96S15-2 ]

Organism-specific databases

CTDi 84219.
GeneCardsi GC16M000734.
HGNCi HGNC:20852. WDR24.
HPAi HPA039506.
neXtProti NX_Q96S15.
PharmGKBi PA134918496.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000234392.
HOVERGENi HBG080644.
InParanoidi Q96S15.
OMAi SWFVDTA.
OrthoDBi EOG7DVD9Z.
PhylomeDBi Q96S15.
TreeFami TF314190.

Enzyme and pathway databases

SignaLinki Q96S15.

Miscellaneous databases

GeneWikii WDR24.
GenomeRNAii 84219.
NextBioi 73642.
PROi Q96S15.

Gene expression databases

Bgeei Q96S15.
CleanExi HS_WDR24.
Genevestigatori Q96S15.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 3 hits.
[Graphical view ]
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
PROSITEi PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney and Lung.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-724, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1."
    Bar-Peled L., Chantranupong L., Cherniack A.D., Chen W.W., Ottina K.A., Grabiner B.C., Spear E.D., Carter S.L., Meyerson M., Sabatini D.M.
    Science 340:1100-1106(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN GATOR COMPLEX, SUBUNIT.

Entry informationi

Entry nameiWDR24_HUMAN
AccessioniPrimary (citable) accession number: Q96S15
Secondary accession number(s): A2IDB8
, D3DU59, Q96GC7, Q9H0B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi