Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96S15

- WDR24_HUMAN

UniProt

Q96S15 - WDR24_HUMAN

Protein

WD repeat-containing protein 24

Gene

WDR24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.

    Enzyme and pathway databases

    SignaLinkiQ96S15.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat-containing protein 24
    Gene namesi
    Name:WDR24
    Synonyms:C16orf21
    ORF Names:JFP7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:20852. WDR24.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134918496.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 920920WD repeat-containing protein 24PRO_0000051375Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei724 – 7241Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96S15.
    PaxDbiQ96S15.
    PRIDEiQ96S15.

    PTM databases

    PhosphoSiteiQ96S15.

    Expressioni

    Gene expression databases

    BgeeiQ96S15.
    CleanExiHS_WDR24.
    GenevestigatoriQ96S15.

    Organism-specific databases

    HPAiHPA039506.

    Interactioni

    Subunit structurei

    Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers.1 Publication

    Protein-protein interaction databases

    BioGridi123953. 2 interactions.
    IntActiQ96S15. 2 interactions.
    MINTiMINT-1444376.
    STRINGi9606.ENSP00000293883.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96S15.
    SMRiQ96S15. Positions 141-453.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati134 – 17441WD 1Add
    BLAST
    Repeati180 – 22041WD 2Add
    BLAST
    Repeati291 – 33141WD 3Add
    BLAST
    Repeati335 – 37541WD 4Add
    BLAST
    Repeati379 – 42143WD 5Add
    BLAST
    Repeati425 – 46844WD 6Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat WDR24 family.Curated
    Contains 6 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000234392.
    HOVERGENiHBG080644.
    InParanoidiQ96S15.
    OMAiSWFVDTA.
    OrthoDBiEOG7DVD9Z.
    PhylomeDBiQ96S15.
    TreeFamiTF314190.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 3 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 6 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.
    PROSITEiPS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96S15-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGKKRTTSGE GRERQRLPAR RFRTTSPAAL RADSVDGGSL LAPLLGLTDR    50
    AFSDCPDLAD GAMEKMSRVT TALGGSVLTG RTMHCHLDAP ANAISVCRDA 100
    AQVVVAGRSI FKIYAIEEEQ FVEKLNLRVG RKPSLNLSCA DVVWHQMDEN 150
    LLATAATNGV VVTWNLGRPS RNKQDQLFTE HKRTVNKVCF HPTEAHVLLS 200
    GSQDGFMKCF DLRRKDSVST FSGEATEAGP REWAMAGCVP ILPVLSCRIL 250
    RLHHSFAHGP MQDAESTAND ARESWGCPLY PLGLCSGPQA GQSESVRDVQ 300
    FSIRDYFTFA STFENGNVQL WDIRRPDRCE RMFTAHNGPV FCCDWHPEDR 350
    GWLATGGRDK MVKVWDMTTH RAKEMHCVQT IASVARVKWR PECRHHLATC 400
    SMMVDHNIYV WDVRRPFVPA AMFEEHRDVT TGIAWRHPHD PSFLLSGSKD 450
    SSLCQHLFRD ASQPVERANP EGLCYGLFGD LAFAAKESLV AAESGRKPYT 500
    GDRRHPIFFK RKLDPAEPFA GLASSALSVF ETEPGGGGMR WFVDTAERYA 550
    LAGRPLAELC DHNAKVAREL GRNQVAQTWT MLRIIYCSPG LVPTANLNHS 600
    VGKGGSCGLP LMNSFNLKDM APGLGSETRL DRSKGDARSD TVLLDSSATL 650
    ITNEDNEETE GSDVPADYLL GDVEGEEDEL YLLDPEHAHP EDPECVLPQE 700
    AFPLRHEIVD TPPGPEHLQD KADSPHVSGS EADVASLAPV DSSFSLLSVS 750
    HALYDSRLPP DFFGVLVRDM LHFYAEQGDV QMAVSVLIVL GERVRKDIDE 800
    QTQEHWYTSY IDLLQRFRLW NVSNEVVKLS TSRAVSCLNQ ASTTLHVNCS 850
    HCKRPMSSRG WVCDRCHRCA SMCAVCHHVV KGLFVWCQGC SHGGHLQHIM 900
    KWLEGSSHCP AGCGHLCEYS 920
    Length:920
    Mass (Da):101,989
    Last modified:December 1, 2001 - v1
    Checksum:i3BE3989D72973714
    GO
    Isoform 2 (identifier: Q96S15-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-62: Missing.
         223-290: Missing.

    Show »
    Length:790
    Mass (Da):88,207
    Checksum:i6C109240F6251898
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6262Missing in isoform 2. 2 PublicationsVSP_016180Add
    BLAST
    Alternative sequencei223 – 29068Missing in isoform 2. 2 PublicationsVSP_016181Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006464 Genomic DNA. Translation: AAK61244.1.
    AL136863 mRNA. Translation: CAB66797.1.
    Z92544 Genomic DNA. Translation: CAM26347.1.
    CH471112 Genomic DNA. Translation: EAW85752.1.
    CH471112 Genomic DNA. Translation: EAW85753.1.
    BC008025 mRNA. Translation: AAH08025.1.
    BC009761 mRNA. Translation: AAH09761.2.
    CCDSiCCDS10420.1. [Q96S15-2]
    RefSeqiNP_115635.1. NM_032259.2. [Q96S15-2]
    UniGeneiHs.459632.

    Genome annotation databases

    EnsembliENST00000248142; ENSP00000248142; ENSG00000127580. [Q96S15-1]
    ENST00000293883; ENSP00000293883; ENSG00000127580. [Q96S15-2]
    GeneIDi84219.
    KEGGihsa:84219.
    UCSCiuc002ciz.1. human. [Q96S15-2]

    Polymorphism databases

    DMDMi74762692.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006464 Genomic DNA. Translation: AAK61244.1 .
    AL136863 mRNA. Translation: CAB66797.1 .
    Z92544 Genomic DNA. Translation: CAM26347.1 .
    CH471112 Genomic DNA. Translation: EAW85752.1 .
    CH471112 Genomic DNA. Translation: EAW85753.1 .
    BC008025 mRNA. Translation: AAH08025.1 .
    BC009761 mRNA. Translation: AAH09761.2 .
    CCDSi CCDS10420.1. [Q96S15-2 ]
    RefSeqi NP_115635.1. NM_032259.2. [Q96S15-2 ]
    UniGenei Hs.459632.

    3D structure databases

    ProteinModelPortali Q96S15.
    SMRi Q96S15. Positions 141-453.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123953. 2 interactions.
    IntActi Q96S15. 2 interactions.
    MINTi MINT-1444376.
    STRINGi 9606.ENSP00000293883.

    PTM databases

    PhosphoSitei Q96S15.

    Polymorphism databases

    DMDMi 74762692.

    Proteomic databases

    MaxQBi Q96S15.
    PaxDbi Q96S15.
    PRIDEi Q96S15.

    Protocols and materials databases

    DNASUi 84219.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248142 ; ENSP00000248142 ; ENSG00000127580 . [Q96S15-1 ]
    ENST00000293883 ; ENSP00000293883 ; ENSG00000127580 . [Q96S15-2 ]
    GeneIDi 84219.
    KEGGi hsa:84219.
    UCSCi uc002ciz.1. human. [Q96S15-2 ]

    Organism-specific databases

    CTDi 84219.
    GeneCardsi GC16M000734.
    HGNCi HGNC:20852. WDR24.
    HPAi HPA039506.
    neXtProti NX_Q96S15.
    PharmGKBi PA134918496.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000234392.
    HOVERGENi HBG080644.
    InParanoidi Q96S15.
    OMAi SWFVDTA.
    OrthoDBi EOG7DVD9Z.
    PhylomeDBi Q96S15.
    TreeFami TF314190.

    Enzyme and pathway databases

    SignaLinki Q96S15.

    Miscellaneous databases

    GeneWikii WDR24.
    GenomeRNAii 84219.
    NextBioi 73642.
    PROi Q96S15.

    Gene expression databases

    Bgeei Q96S15.
    CleanExi HS_WDR24.
    Genevestigatori Q96S15.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 3 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 6 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    PROSITEi PS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
      Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
      Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney and Lung.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-724, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. "A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1."
      Bar-Peled L., Chantranupong L., Cherniack A.D., Chen W.W., Ottina K.A., Grabiner B.C., Spear E.D., Carter S.L., Meyerson M., Sabatini D.M.
      Science 340:1100-1106(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN GATOR COMPLEX, SUBUNIT.

    Entry informationi

    Entry nameiWDR24_HUMAN
    AccessioniPrimary (citable) accession number: Q96S15
    Secondary accession number(s): A2IDB8
    , D3DU59, Q96GC7, Q9H0B7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3