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Q96S15 (WDR24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WD repeat-containing protein 24
Gene names
Name:WDR24
Synonyms:C16orf21
ORF Names:JFP7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length920 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.

Subunit structure

Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers. Ref.7

Sequence similarities

Belongs to the WD repeat WDR24 family.

Contains 6 WD repeats.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainRepeat
WD repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96S15-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96S15-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     223-290: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 920920WD repeat-containing protein 24
PRO_0000051375

Regions

Repeat134 – 17441WD 1
Repeat180 – 22041WD 2
Repeat291 – 33141WD 3
Repeat335 – 37541WD 4
Repeat379 – 42143WD 5
Repeat425 – 46844WD 6

Amino acid modifications

Modified residue7241Phosphoserine Ref.6

Natural variations

Alternative sequence1 – 6262Missing in isoform 2.
VSP_016180
Alternative sequence223 – 29068Missing in isoform 2.
VSP_016181

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 3BE3989D72973714

FASTA920101,989
        10         20         30         40         50         60 
MGKKRTTSGE GRERQRLPAR RFRTTSPAAL RADSVDGGSL LAPLLGLTDR AFSDCPDLAD 

        70         80         90        100        110        120 
GAMEKMSRVT TALGGSVLTG RTMHCHLDAP ANAISVCRDA AQVVVAGRSI FKIYAIEEEQ 

       130        140        150        160        170        180 
FVEKLNLRVG RKPSLNLSCA DVVWHQMDEN LLATAATNGV VVTWNLGRPS RNKQDQLFTE 

       190        200        210        220        230        240 
HKRTVNKVCF HPTEAHVLLS GSQDGFMKCF DLRRKDSVST FSGEATEAGP REWAMAGCVP 

       250        260        270        280        290        300 
ILPVLSCRIL RLHHSFAHGP MQDAESTAND ARESWGCPLY PLGLCSGPQA GQSESVRDVQ 

       310        320        330        340        350        360 
FSIRDYFTFA STFENGNVQL WDIRRPDRCE RMFTAHNGPV FCCDWHPEDR GWLATGGRDK 

       370        380        390        400        410        420 
MVKVWDMTTH RAKEMHCVQT IASVARVKWR PECRHHLATC SMMVDHNIYV WDVRRPFVPA 

       430        440        450        460        470        480 
AMFEEHRDVT TGIAWRHPHD PSFLLSGSKD SSLCQHLFRD ASQPVERANP EGLCYGLFGD 

       490        500        510        520        530        540 
LAFAAKESLV AAESGRKPYT GDRRHPIFFK RKLDPAEPFA GLASSALSVF ETEPGGGGMR 

       550        560        570        580        590        600 
WFVDTAERYA LAGRPLAELC DHNAKVAREL GRNQVAQTWT MLRIIYCSPG LVPTANLNHS 

       610        620        630        640        650        660 
VGKGGSCGLP LMNSFNLKDM APGLGSETRL DRSKGDARSD TVLLDSSATL ITNEDNEETE 

       670        680        690        700        710        720 
GSDVPADYLL GDVEGEEDEL YLLDPEHAHP EDPECVLPQE AFPLRHEIVD TPPGPEHLQD 

       730        740        750        760        770        780 
KADSPHVSGS EADVASLAPV DSSFSLLSVS HALYDSRLPP DFFGVLVRDM LHFYAEQGDV 

       790        800        810        820        830        840 
QMAVSVLIVL GERVRKDIDE QTQEHWYTSY IDLLQRFRLW NVSNEVVKLS TSRAVSCLNQ 

       850        860        870        880        890        900 
ASTTLHVNCS HCKRPMSSRG WVCDRCHRCA SMCAVCHHVV KGLFVWCQGC SHGGHLQHIM 

       910        920 
KWLEGSSHCP AGCGHLCEYS 

« Hide

Isoform 2 [UniParc].

Checksum: 6C109240F6251898
Show »

FASTA79088,207

References

« Hide 'large scale' references
[1]"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[3]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Kidney and Lung.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-724, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[7]"A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1."
Bar-Peled L., Chantranupong L., Cherniack A.D., Chen W.W., Ottina K.A., Grabiner B.C., Spear E.D., Carter S.L., Meyerson M., Sabatini D.M.
Science 340:1100-1106(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN GATOR COMPLEX, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006464 Genomic DNA. Translation: AAK61244.1.
AL136863 mRNA. Translation: CAB66797.1.
Z92544 Genomic DNA. Translation: CAM26347.1.
CH471112 Genomic DNA. Translation: EAW85752.1.
CH471112 Genomic DNA. Translation: EAW85753.1.
BC008025 mRNA. Translation: AAH08025.1.
BC009761 mRNA. Translation: AAH09761.2.
CCDSCCDS10420.1. [Q96S15-2]
RefSeqNP_115635.1. NM_032259.2. [Q96S15-2]
UniGeneHs.459632.

3D structure databases

ProteinModelPortalQ96S15.
SMRQ96S15. Positions 141-453.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123953. 2 interactions.
IntActQ96S15. 2 interactions.
MINTMINT-1444376.
STRING9606.ENSP00000293883.

PTM databases

PhosphoSiteQ96S15.

Polymorphism databases

DMDM74762692.

Proteomic databases

MaxQBQ96S15.
PaxDbQ96S15.
PRIDEQ96S15.

Protocols and materials databases

DNASU84219.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000248142; ENSP00000248142; ENSG00000127580. [Q96S15-1]
ENST00000293883; ENSP00000293883; ENSG00000127580. [Q96S15-2]
GeneID84219.
KEGGhsa:84219.
UCSCuc002ciz.1. human. [Q96S15-2]

Organism-specific databases

CTD84219.
GeneCardsGC16M000734.
HGNCHGNC:20852. WDR24.
HPAHPA039506.
neXtProtNX_Q96S15.
PharmGKBPA134918496.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2319.
HOGENOMHOG000234392.
HOVERGENHBG080644.
InParanoidQ96S15.
OMASWFVDTA.
OrthoDBEOG7DVD9Z.
PhylomeDBQ96S15.
TreeFamTF314190.

Enzyme and pathway databases

SignaLinkQ96S15.

Gene expression databases

BgeeQ96S15.
CleanExHS_WDR24.
GenevestigatorQ96S15.

Family and domain databases

Gene3D2.130.10.10. 2 hits.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 3 hits.
[Graphical view]
SMARTSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 2 hits.
PROSITEPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiWDR24.
GenomeRNAi84219.
NextBio73642.
PROQ96S15.

Entry information

Entry nameWDR24_HUMAN
AccessionPrimary (citable) accession number: Q96S15
Secondary accession number(s): A2IDB8 expand/collapse secondary AC list , D3DU59, Q96GC7, Q9H0B7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM