Q96S15 (WDR24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 24

Gene names

Name:	WDR24
Synonyms:	C16orf21
ORF Names:	JFP7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	920 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the WD repeat WDR24 family. Contains 6 WD repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat WD repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein import into peroxisome matrix Inferred from electronic annotation. Source: InterPro
Cellular_component	peroxisome Inferred from electronic annotation. Source: InterPro
Molecular_function	peroxisome matrix targeting signal-2 binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96S15-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96S15-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     223-290: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 920	920	WD repeat-containing protein 24		PRO_0000051375
Regions
	Repeat	134 – 174	41	WD 1
	Repeat	180 – 220	41	WD 2
	Repeat	291 – 331	41	WD 3
	Repeat	335 – 375	41	WD 4
	Repeat	379 – 421	43	WD 5
	Repeat	425 – 468	44	WD 6
Amino acid modifications
	Modified residue	724	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	1 – 62	62	Missing in isoform 2.		VSP_016180
	Alternative sequence	223 – 290	68	Missing in isoform 2.		VSP_016181

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 3BE3989D72973714	FASTA	920	101,989
	10 20 30 40 50 60 MGKKRTTSGE GRERQRLPAR RFRTTSPAAL RADSVDGGSL LAPLLGLTDR AFSDCPDLAD 70 80 90 100 110 120 GAMEKMSRVT TALGGSVLTG RTMHCHLDAP ANAISVCRDA AQVVVAGRSI FKIYAIEEEQ 130 140 150 160 170 180 FVEKLNLRVG RKPSLNLSCA DVVWHQMDEN LLATAATNGV VVTWNLGRPS RNKQDQLFTE 190 200 210 220 230 240 HKRTVNKVCF HPTEAHVLLS GSQDGFMKCF DLRRKDSVST FSGEATEAGP REWAMAGCVP 250 260 270 280 290 300 ILPVLSCRIL RLHHSFAHGP MQDAESTAND ARESWGCPLY PLGLCSGPQA GQSESVRDVQ 310 320 330 340 350 360 FSIRDYFTFA STFENGNVQL WDIRRPDRCE RMFTAHNGPV FCCDWHPEDR GWLATGGRDK 370 380 390 400 410 420 MVKVWDMTTH RAKEMHCVQT IASVARVKWR PECRHHLATC SMMVDHNIYV WDVRRPFVPA 430 440 450 460 470 480 AMFEEHRDVT TGIAWRHPHD PSFLLSGSKD SSLCQHLFRD ASQPVERANP EGLCYGLFGD 490 500 510 520 530 540 LAFAAKESLV AAESGRKPYT GDRRHPIFFK RKLDPAEPFA GLASSALSVF ETEPGGGGMR 550 560 570 580 590 600 WFVDTAERYA LAGRPLAELC DHNAKVAREL GRNQVAQTWT MLRIIYCSPG LVPTANLNHS 610 620 630 640 650 660 VGKGGSCGLP LMNSFNLKDM APGLGSETRL DRSKGDARSD TVLLDSSATL ITNEDNEETE 670 680 690 700 710 720 GSDVPADYLL GDVEGEEDEL YLLDPEHAHP EDPECVLPQE AFPLRHEIVD TPPGPEHLQD 730 740 750 760 770 780 KADSPHVSGS EADVASLAPV DSSFSLLSVS HALYDSRLPP DFFGVLVRDM LHFYAEQGDV 790 800 810 820 830 840 QMAVSVLIVL GERVRKDIDE QTQEHWYTSY IDLLQRFRLW NVSNEVVKLS TSRAVSCLNQ 850 860 870 880 890 900 ASTTLHVNCS HCKRPMSSRG WVCDRCHRCA SMCAVCHHVV KGLFVWCQGC SHGGHLQHIM 910 920 KWLEGSSHCP AGCGHLCEYS
	Isoform 2 [UniParc]. Checksum: 6C109240F6251898	FASTA	790	88,207
	10 20 30 40 50 60 MEKMSRVTTA LGGSVLTGRT MHCHLDAPAN AISVCRDAAQ VVVAGRSIFK IYAIEEEQFV 70 80 90 100 110 120 EKLNLRVGRK PSLNLSCADV VWHQMDENLL ATAATNGVVV TWNLGRPSRN KQDQLFTEHK 130 140 150 160 170 180 RTVNKVCFHP TEAHVLLSGS QDGFMKCFDL RRKDSVSTFS GQSESVRDVQ FSIRDYFTFA 190 200 210 220 230 240 STFENGNVQL WDIRRPDRCE RMFTAHNGPV FCCDWHPEDR GWLATGGRDK MVKVWDMTTH 250 260 270 280 290 300 RAKEMHCVQT IASVARVKWR PECRHHLATC SMMVDHNIYV WDVRRPFVPA AMFEEHRDVT 310 320 330 340 350 360 TGIAWRHPHD PSFLLSGSKD SSLCQHLFRD ASQPVERANP EGLCYGLFGD LAFAAKESLV 370 380 390 400 410 420 AAESGRKPYT GDRRHPIFFK RKLDPAEPFA GLASSALSVF ETEPGGGGMR WFVDTAERYA 430 440 450 460 470 480 LAGRPLAELC DHNAKVAREL GRNQVAQTWT MLRIIYCSPG LVPTANLNHS VGKGGSCGLP 490 500 510 520 530 540 LMNSFNLKDM APGLGSETRL DRSKGDARSD TVLLDSSATL ITNEDNEETE GSDVPADYLL 550 560 570 580 590 600 GDVEGEEDEL YLLDPEHAHP EDPECVLPQE AFPLRHEIVD TPPGPEHLQD KADSPHVSGS 610 620 630 640 650 660 EADVASLAPV DSSFSLLSVS HALYDSRLPP DFFGVLVRDM LHFYAEQGDV QMAVSVLIVL 670 680 690 700 710 720 GERVRKDIDE QTQEHWYTSY IDLLQRFRLW NVSNEVVKLS TSRAVSCLNQ ASTTLHVNCS 730 740 750 760 770 780 HCKRPMSSRG WVCDRCHRCA SMCAVCHHVV KGLFVWCQGC SHGGHLQHIM KWLEGSSHCP 790 AGCGHLCEYS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Kidney and Lung.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-724, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006464 Genomic DNA. Translation: AAK61244.1. AL136863 mRNA. Translation: CAB66797.1. Z92544 Genomic DNA. Translation: CAM26347.1. CH471112 Genomic DNA. Translation: EAW85752.1. CH471112 Genomic DNA. Translation: EAW85753.1. BC008025 mRNA. Translation: AAH08025.1. BC009761 mRNA. Translation: AAH09761.2.
IPI	IPI00031042. IPI00045472.
RefSeq	NP_115635.1. NM_032259.2.
UniGene	Hs.459632.
3D structure databases
ProteinModelPortal	Q96S15.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96S15. 2 interactions.
MINT	MINT-1444376.
STRING	9606.ENSP00000293883.
PTM databases
PhosphoSite	Q96S15.
Polymorphism databases
DMDM	74762692.
Proteomic databases
PaxDb	Q96S15.
PRIDE	Q96S15.
Protocols and materials databases
DNASU	84219.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000248142; ENSP00000248142; ENSG00000127580. ENST00000293883; ENSP00000293883; ENSG00000127580.
GeneID	84219.
KEGG	hsa:84219.
UCSC	uc002ciz.1. human.
Organism-specific databases
CTD	84219.
GeneCards	GC16M000734.
HGNC	HGNC:20852. WDR24.
HPA	HPA039506.
neXtProt	NX_Q96S15.
PharmGKB	PA134918496.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2319.
HOGENOM	HOG000234392.
HOVERGEN	HBG080644.
InParanoid	Q96S15.
OMA	HALYDSR.
OrthoDB	EOG48WC1D.
PhylomeDB	Q96S15.
Gene expression databases
Bgee	Q96S15.
CleanEx	HS_WDR24.
Genevestigator	Q96S15.
GermOnline	ENSG00000127580. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 2 hits.
InterPro	IPR025651. PEX7-like_WD_rpt. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
PANTHER	PTHR22850:SF4. PTHR22850:SF4. 1 hit.
Pfam	PF00400. WD40. 3 hits. [Graphical view]
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 3 hits. PS50082. WD_REPEATS_2. 2 hits. PS50294. WD_REPEATS_REGION. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84219.
NextBio	73642.

Entry information

Entry name

WDR24_HUMAN

Accession

Primary (citable) accession number: Q96S15
Secondary accession number(s): A2IDB8 , D3DU59, Q96GC7, Q9H0B7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.