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Q96RY7

- IF140_HUMAN

UniProt

Q96RY7 - IF140_HUMAN

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Protein
Intraflagellar transport protein 140 homolog
Gene
IFT140, KIAA0590, WDTC2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance.1 Publication

GO - Biological processi

  1. cilium assembly Source: Ensembl
  2. protein localization to cilium Source: UniProt
  3. regulation of cilium assembly Source: UniProt
  4. renal system development Source: UniProt
  5. retina development in camera-type eye Source: UniProt
  6. skeletal system morphogenesis Source: UniProt
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

SignaLinkiQ96RY7.

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 140 homolog
Alternative name(s):
WD and tetratricopeptide repeats protein 2
Gene namesi
Name:IFT140
Synonyms:KIAA0590, WDTC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:29077. IFT140.

Subcellular locationi

Cytoplasmcytoskeletoncilium basal body. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 2 Publications

GO - Cellular componenti

  1. axoneme Source: UniProt
  2. centrosome Source: UniProt
  3. ciliary basal body Source: UniProtKB
  4. intraciliary transport particle A Source: UniProtKB
  5. photoreceptor connecting cilium Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Short-rib thoracic dysplasia 9 with or without polydactyly (SRTD9) [MIM:266920]: A form of short-rib thoracic dysplasia, a group of autosomal recessive ciliopathies that are characterized by a constricted thoracic cage, short ribs, shortened tubular bones, and a 'trident' appearance of the acetabular roof. Polydactyly is variably present. Non-skeletal involvement can include cleft lip/palate as well as anomalies of major organs such as the brain, eye, heart, kidneys, liver, pancreas, intestines, and genitalia. Some forms of the disease are lethal in the neonatal period due to respiratory insufficiency secondary to a severely restricted thoracic cage, whereas others are compatible with life. Disease spectrum encompasses Ellis-van Creveld syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly syndrome. SRTD9 is characterized by phalangeal cone-shaped epiphyses, chronic renal disease, nearly constant retinal dystrophy, and mild radiographic abnormality of the proximal femur. Occasional features include short stature, cerebellar ataxia, and hepatic fibrosis.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti152 – 1521L → F in SRTD9. 1 Publication
VAR_071000
Natural varianti212 – 2121G → R in SRTD9; partial to complete loss of basal body localization and increase of cytoplasmic localization. 1 Publication
VAR_068523
Natural varianti233 – 2331I → M in SRTD9. 1 Publication
VAR_068524
Natural varianti267 – 2671E → G in SRTD9; disease phenotype consistent with Mainzer-Saldino syndrome. 1 Publication
VAR_071003
Natural varianti292 – 2921V → M in SRTD9; impairs centrosomal localization. 2 Publications
VAR_068525
Natural varianti311 – 3111Y → C in SRTD9; partial to complete loss of basal body localization and increase of cytoplasmic localization. 1 Publication
VAR_068526
Natural varianti522 – 5221G → E in SRTD9. 2 Publications
VAR_068527
Natural varianti576 – 5761R → Q in SRTD9. 1 Publication
VAR_068528
Natural varianti664 – 6641E → K in SRTD9; partial to complete loss of basal body localization and increase of cytoplasmic localization. 1 Publication
VAR_068529
Natural varianti1360 – 13601C → R in SRTD9; disease phenotype consistent with Mainzer-Saldino syndrome. 1 Publication
VAR_071008

Keywords - Diseasei

Ciliopathy, Disease mutation

Organism-specific databases

MIMi266920. phenotype.
Orphaneti474. Jeune syndrome.
140969. Saldino-Mainzer syndrome.
PharmGKBiPA142671665.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14621462Intraflagellar transport protein 140 homolog
PRO_0000051046Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1443 – 14431Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96RY7.
PaxDbiQ96RY7.
PRIDEiQ96RY7.

PTM databases

PhosphoSiteiQ96RY7.

Expressioni

Gene expression databases

ArrayExpressiQ96RY7.
BgeeiQ96RY7.
CleanExiHS_IFT140.
GenevestigatoriQ96RY7.

Organism-specific databases

HPAiHPA042197.

Interactioni

Subunit structurei

Component of the IFT complex A (IFT-A).1 Publication

Protein-protein interaction databases

BioGridi115090. 4 interactions.
IntActiQ96RY7. 4 interactions.
MINTiMINT-8247576.
STRINGi9606.ENSP00000354895.

Structurei

3D structure databases

ProteinModelPortaliQ96RY7.
SMRiQ96RY7. Positions 65-132, 195-220, 902-927, 955-1004.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati13 – 5745WD 1
Add
BLAST
Repeati59 – 9840WD 2
Add
BLAST
Repeati101 – 14040WD 3
Add
BLAST
Repeati263 – 31351WD 4
Add
BLAST
Repeati322 – 36140WD 5
Add
BLAST
Repeati772 – 80736TPR 1
Add
BLAST
Repeati869 – 90436TPR 2
Add
BLAST
Repeati906 – 93429TPR 3
Add
BLAST
Repeati955 – 98834TPR 4
Add
BLAST
Repeati1010 – 104334TPR 5
Add
BLAST
Repeati1078 – 111134TPR 6
Add
BLAST
Repeati1123 – 115634TPR 7
Add
BLAST
Repeati1189 – 122234TPR 8
Add
BLAST
Repeati1376 – 140934TPR 9
Add
BLAST

Sequence similaritiesi

Contains 9 TPR repeats.
Contains 5 WD repeats.

Keywords - Domaini

Repeat, TPR repeat, WD repeat

Phylogenomic databases

eggNOGiNOG301450.
HOGENOMiHOG000230867.
HOVERGENiHBG055589.
InParanoidiQ96RY7.
OMAiKGRVAMW.
PhylomeDBiQ96RY7.
TreeFamiTF105851.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RY7-1 [UniParc]FASTAAdd to Basket

« Hide

MALYYDHQIE APDAAGSPSF ISWHPVHPFL AVAYISTTST GSVDIYLEQG     50
ECVPDTHVER PFRVASLCWH PTRLVLAVGW ETGEVTVFNK QDKEQHTMPL 100
THTADITVLR WSPSGNCLLS GDRLGVLLLW RLDQRGRVQG TPLLKHEYGK 150
HLTHCIFRLP PPGEDLVQLA KAAVSGDEKA LDMFNWKKSS SGSLLKMGSH 200
EGLLFFVSLM DGTVHYVDEK GKTTQVVSAD STIQMLFYME KREALVVVTE 250
NLRLSLYTVP PEGKAEEVMK VKLSGKTGRR ADIALIEGSL LVMAVGEAAL 300
RFWDIERGEN YILSPDEKFG FEKGENMNCV CYCKVKGLLA AGTDRGRVAM 350
WRKVPDFLGS PGAEGKDRWA LQTPTELQGN ITQIQWGSRK NLLAVNSVIS 400
VAILSERAMS SHFHQQVAAM QVSPSLLNVC FLSTGVAHSL RTDMHISGVF 450
ATKDAVAVWN GRQVAIFELS GAAIRSAGTF LCETPVLAMH EENVYTVESN 500
RVQVRTWQGT VKQLLLFSET EGNPCFLDIC GNFLVVGTDL AHFKSFDLSR 550
REAKAHCSCR SLAELVPGVG GIASLRCSSS GSTISILPSK ADNSPDSKIC 600
FYDVEMDTVT VFDFKTGQID RRETLSFNEQ ETNKSHLFVD EGLKNYVPVN 650
HFWDQSEPRL FVCEAVQETP RSQPQSANGQ PQDGRAGPAA DVLILSFFIS 700
EEHGFLLHES FPRPATSHSL LGMEVPYYYF TRKPEEADRE DEVEPGCHHI 750
PQMVSRRPLR DFVGLEDCDK ATRDAMLHFS FFVTIGDMDE AFKSIKLIKS 800
EAVWENMARM CVKTQRLDVA KVCLGNMGHA RGARALREAE QEPELEARVA 850
VLATQLGMLE DAEQLYRKCK RHDLLNKFYQ AAGRWQEALQ VAEHHDRVHL 900
RSTYHRYAGH LEASADCSRA LSYYEKSDTH RFEVPRMLSE DLPSLELYVN 950
KMKDKTLWRW WAQYLESQGE MDAALHYYEL ARDHFSLVRI HCFQGNVQKA 1000
AQIANETGNL AASYHLARQY ESQEEVGQAV HFYTRAQAFK NAIRLCKENG 1050
LDDQLMNLAL LSSPEDMIEA ARYYEEKGVQ MDRAVMLYHK AGHFSKALEL 1100
AFATQQFVAL QLIAEDLDET SDPALLARCS DFFIEHSQYE RAVELLLAAR 1150
KYQEALQLCL GQNMSITEEM AEKMTVAKDS SDLPEESRRE LLEQIADCCM 1200
RQGSYHLATK KYTQAGNKLK AMRALLKSGD TEKITFFASV SRQKEIYIMA 1250
ANYLQSLDWR KEPEIMKNII GFYTKGRALD LLAGFYDACA QVEIDEYQNY 1300
DKAHGALTEA YKCLAKAKAK SPLDQETRLA QLQSRMALVK RFIQARRTYT 1350
EDPKESIKQC ELLLEEPDLD STIRIGDVYG FLVEHYVRKE EYQTAYRFLE 1400
EMRRRLPLAN MSYYVSPQAV DAVHRGLGLP LPRTVPEQVR HNSMEDAREL 1450
DEEVVEEADD DP 1462
Length:1,462
Mass (Da):165,193
Last modified:December 1, 2001 - v1
Checksum:i2F3CCBD998F80E3B
GO

Sequence cautioni

The sequence BAA25516.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101R → H.1 Publication
Corresponds to variant rs371077545 [ dbSNP | Ensembl ].
VAR_070999
Natural varianti152 – 1521L → F in SRTD9. 1 Publication
VAR_071000
Natural varianti161 – 1611P → T.1 Publication
VAR_071001
Natural varianti165 – 1651D → A.
Corresponds to variant rs35588860 [ dbSNP | Ensembl ].
VAR_053396
Natural varianti212 – 2121G → R in SRTD9; partial to complete loss of basal body localization and increase of cytoplasmic localization. 1 Publication
VAR_068523
Natural varianti233 – 2331I → M in SRTD9. 1 Publication
VAR_068524
Natural varianti243 – 2431E → G.1 Publication
VAR_071002
Natural varianti267 – 2671E → G in SRTD9; disease phenotype consistent with Mainzer-Saldino syndrome. 1 Publication
VAR_071003
Natural varianti279 – 2791R → P.
Corresponds to variant rs4786350 [ dbSNP | Ensembl ].
VAR_053397
Natural varianti280 – 2801R → Q.
Corresponds to variant rs35404373 [ dbSNP | Ensembl ].
VAR_053398
Natural varianti292 – 2921V → M in SRTD9; impairs centrosomal localization. 2 Publications
VAR_068525
Natural varianti311 – 3111Y → C in SRTD9; partial to complete loss of basal body localization and increase of cytoplasmic localization. 1 Publication
VAR_068526
Natural varianti398 – 3981V → I.
Corresponds to variant rs34762152 [ dbSNP | Ensembl ].
VAR_053399
Natural varianti451 – 4511A → V.
Corresponds to variant rs8060532 [ dbSNP | Ensembl ].
VAR_053400
Natural varianti459 – 4591W → S.1 Publication
VAR_071004
Natural varianti514 – 5141L → H.1 Publication
Corresponds to variant rs150903791 [ dbSNP | Ensembl ].
VAR_071005
Natural varianti522 – 5221G → E in SRTD9. 2 Publications
VAR_068527
Natural varianti561 – 5611S → N.
Corresponds to variant rs8050974 [ dbSNP | Ensembl ].
VAR_062098
Natural varianti576 – 5761R → Q in SRTD9. 1 Publication
VAR_068528
Natural varianti621 – 6211R → Q.
Corresponds to variant rs11648609 [ dbSNP | Ensembl ].
VAR_053401
Natural varianti664 – 6641E → K in SRTD9; partial to complete loss of basal body localization and increase of cytoplasmic localization. 1 Publication
VAR_068529
Natural varianti670 – 6701P → S.
Corresponds to variant rs34900355 [ dbSNP | Ensembl ].
VAR_053402
Natural varianti787 – 7871D → G.1 Publication
Corresponds to variant rs144938800 [ dbSNP | Ensembl ].
VAR_071006
Natural varianti1070 – 10701A → V.1 Publication
Corresponds to variant rs2235638 [ dbSNP | Ensembl ].
VAR_053403
Natural varianti1353 – 13531P → R.1 Publication
VAR_071007
Natural varianti1360 – 13601C → R in SRTD9; disease phenotype consistent with Mainzer-Saldino syndrome. 1 Publication
VAR_071008

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti542 – 5421H → L in BAA25516. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011162 mRNA. Translation: BAA25516.2. Different initiation.
AE006467 Genomic DNA. Translation: AAK61285.1.
AL031705
, AL031719, AL133297, Z97633, Z97652 Genomic DNA. Translation: CAM26342.1.
Z97633
, AL031705, AL031719, AL133297, Z97652 Genomic DNA. Translation: CAM26352.1.
AL031719
, AL031705, AL133297, Z97633, Z97652 Genomic DNA. Translation: CAM26410.1.
Z97652
, AL031705, AL031719, AL133297, Z97633 Genomic DNA. Translation: CAM26430.1.
AL133297
, AL031705, AL031719, Z97633, Z97652 Genomic DNA. Translation: CAM26447.1.
CH471112 Genomic DNA. Translation: EAW85642.1.
CH471112 Genomic DNA. Translation: EAW85644.1.
BC035577 mRNA. Translation: AAH35577.1.
CCDSiCCDS10439.1.
PIRiT00345.
RefSeqiNP_055529.2. NM_014714.3.
XP_006721052.1. XM_006720989.1.
XP_006721053.1. XM_006720990.1.
XP_006721054.1. XM_006720991.1.
UniGeneiHs.389438.

Genome annotation databases

EnsembliENST00000426508; ENSP00000406012; ENSG00000187535.
GeneIDi9742.
KEGGihsa:9742.
UCSCiuc002clz.3. human.

Polymorphism databases

DMDMi74761083.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011162 mRNA. Translation: BAA25516.2 . Different initiation.
AE006467 Genomic DNA. Translation: AAK61285.1 .
AL031705
, AL031719 , AL133297 , Z97633 , Z97652 Genomic DNA. Translation: CAM26342.1 .
Z97633
, AL031705 , AL031719 , AL133297 , Z97652 Genomic DNA. Translation: CAM26352.1 .
AL031719
, AL031705 , AL133297 , Z97633 , Z97652 Genomic DNA. Translation: CAM26410.1 .
Z97652
, AL031705 , AL031719 , AL133297 , Z97633 Genomic DNA. Translation: CAM26430.1 .
AL133297
, AL031705 , AL031719 , Z97633 , Z97652 Genomic DNA. Translation: CAM26447.1 .
CH471112 Genomic DNA. Translation: EAW85642.1 .
CH471112 Genomic DNA. Translation: EAW85644.1 .
BC035577 mRNA. Translation: AAH35577.1 .
CCDSi CCDS10439.1.
PIRi T00345.
RefSeqi NP_055529.2. NM_014714.3.
XP_006721052.1. XM_006720989.1.
XP_006721053.1. XM_006720990.1.
XP_006721054.1. XM_006720991.1.
UniGenei Hs.389438.

3D structure databases

ProteinModelPortali Q96RY7.
SMRi Q96RY7. Positions 65-132, 195-220, 902-927, 955-1004.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115090. 4 interactions.
IntActi Q96RY7. 4 interactions.
MINTi MINT-8247576.
STRINGi 9606.ENSP00000354895.

PTM databases

PhosphoSitei Q96RY7.

Polymorphism databases

DMDMi 74761083.

Proteomic databases

MaxQBi Q96RY7.
PaxDbi Q96RY7.
PRIDEi Q96RY7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000426508 ; ENSP00000406012 ; ENSG00000187535 .
GeneIDi 9742.
KEGGi hsa:9742.
UCSCi uc002clz.3. human.

Organism-specific databases

CTDi 9742.
GeneCardsi GC16M001560.
HGNCi HGNC:29077. IFT140.
HPAi HPA042197.
MIMi 266920. phenotype.
614620. gene.
neXtProti NX_Q96RY7.
Orphaneti 474. Jeune syndrome.
140969. Saldino-Mainzer syndrome.
PharmGKBi PA142671665.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG301450.
HOGENOMi HOG000230867.
HOVERGENi HBG055589.
InParanoidi Q96RY7.
OMAi KGRVAMW.
PhylomeDBi Q96RY7.
TreeFami TF105851.

Enzyme and pathway databases

SignaLinki Q96RY7.

Miscellaneous databases

ChiTaRSi IFT140. human.
GenomeRNAii 9742.
NextBioi 36659.
PROi Q96RY7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96RY7.
Bgeei Q96RY7.
CleanExi HS_IFT140.
Genevestigatori Q96RY7.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 3 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 4 hits.
PROSITEi PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-1070.
    Tissue: Brain.
  2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1443, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia."
    Mukhopadhyay S., Wen X., Chih B., Nelson C.D., Lane W.S., Scales S.J., Jackson P.K.
    Genes Dev. 24:2180-2193(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE IFT-A COMPLEX.
  9. Cited for: FUNCTION, SUBCELLULAR LOCATION, VARIANTS SRTD9 ARG-212; MET-233; MET-292; CYS-311; GLU-522; GLN-576 AND LYS-664, CHARACTERIZATION OF VARIANTS SRTD9 ARG-212; CYS-311 AND LYS-664.
  10. Cited for: SUBCELLULAR LOCATION, VARIANTS HIS-110; THR-161; GLY-243; SER-459; HIS-514; GLY-787 AND ARG-1353, VARIANTS SRTD9 PHE-152; GLY-267; MET-292; GLU-522 AND ARG-1360, CHARACTERIZATION OF VARIANT SRTD9 MET-292.

Entry informationi

Entry nameiIF140_HUMAN
AccessioniPrimary (citable) accession number: Q96RY7
Secondary accession number(s): A2A2A8, D3DU75, O60332
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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