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Protein

Protein cramped-like

Gene

CRAMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cramped-likeCurated
Alternative name(s):
Cramped chromatin regulator homolog 1Imported
Hematological and neurological expressed 1-like protein
Gene namesi
Name:CRAMP1Imported
Synonyms:C16orf34, CRAMP1L, HN1L, KIAA1426
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14122. CRAMP1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000007545.
PharmGKBiPA26861.

Polymorphism and mutation databases

BioMutaiCRAMP1L.
DMDMi308153609.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002644711 – 1269Protein cramped-likeAdd BLAST1269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei307PhosphoserineCombined sources1
Modified residuei1268PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96RY5.
MaxQBiQ96RY5.
PaxDbiQ96RY5.
PeptideAtlasiQ96RY5.
PRIDEiQ96RY5.

PTM databases

iPTMnetiQ96RY5.
PhosphoSitePlusiQ96RY5.

Expressioni

Gene expression databases

BgeeiENSG00000007545.
CleanExiHS_CRAMP1L.
HS_HN1L.
ExpressionAtlasiQ96RY5. baseline and differential.
GenevisibleiQ96RY5. HS.

Organism-specific databases

HPAiHPA041752.

Interactioni

Protein-protein interaction databases

BioGridi121637. 12 interactors.
IntActiQ96RY5. 3 interactors.
MINTiMINT-1370680.
STRINGi9606.ENSP00000293925.

Structurei

3D structure databases

ProteinModelPortaliQ96RY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 224SANTPROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1069 – 1246Ser-richAdd BLAST178

Sequence similaritiesi

Belongs to the cramped family.Curated
Contains 1 SANT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFWT. Eukaryota.
ENOG4110SYD. LUCA.
GeneTreeiENSGT00390000003337.
HOGENOMiHOG000049034.
HOVERGENiHBG079959.
InParanoidiQ96RY5.
OMAiHWQEGGR.
OrthoDBiEOG091G050A.
PhylomeDBiQ96RY5.
TreeFamiTF328521.

Family and domain databases

InterProiIPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
PROSITEiPS51293. SANT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVKLGDGGS GEDGLKKLGK RAADEESLEG EGAGGADAAE ESSGTKRDEK
60 70 80 90 100
TPRAGADGPP APPGAPQAPS PPQGSPQDQH HFLRSSVRPQ SKRPRKDPPS
110 120 130 140 150
AVGSGNAGGS GPRGKGAEGG GSSSGNVSGV APAAPAGGSR SSSRNLGSSG
160 170 180 190 200
GEKEEGKKVR RQWESWSTED KNTFFEGLYE HGKDFEAIQN NIALKYKKKG
210 220 230 240 250
KPASMVKNKE QVRHFYYRTW HKITKYIDFD HVFSRGLKKS SQELYGLICY
260 270 280 290 300
GELRKKIGGC MDDKNATKLN ELIQVGATTV RYKGRNLRIK APMCRALKKL
310 320 330 340 350
CDPDGLSDEE DQKPVRLPLK VPIELQPRNN HAWARVQSLA QNPRLRMIVE
360 370 380 390 400
LHRKVSSLIE FLKQKWALHE VRVRKTLEER QLQDSCSAPM QEKVTLHLFP
410 420 430 440 450
GENCTLTPLP GVARVVHSKA FCTVHWQEGG RCKQSAKDAH VLPPAQILGI
460 470 480 490 500
QSGQGTARGQ VKCPRSGAEG KGVGRPPPAA DALQSSGESS PESAPGEGAA
510 520 530 540 550
LSLSSPDAPD RPPPRHQDTG PCLEKTPAEG RDSPTREPGA LPCACGQLPD
560 570 580 590 600
LEDELSLLDP LPRYLKSCQD LIVPEQCRCA DTRPGSEQPP LGGAASPEVL
610 620 630 640 650
APVSKEAADL APTGPSPRPG PGLLLDVCTK DLADAPAEEL QEKGSPAGPP
660 670 680 690 700
PSQGQPAARP PKEVPASRLA QQLREEGWNL QTSESLTLAE VYLMMGKPSK
710 720 730 740 750
LQLEYDWLGP GRQDPRPGSL PTALHKQRLL SCLLKLISTE VNPKLALEAN
760 770 780 790 800
TISTASVRPA QEEQSMTPPG KVVTVSSRSP RCPRNQASLR SSKTFPPSSA
810 820 830 840 850
PCSSGLRNPP RPLLVPGPSS TGSNDSDGGL FAVPTTLPPN SRHGKLFSPS
860 870 880 890 900
KEAELTFRQH LNSISMQSDF FLPKPRKLRN RHLRKPLVVQ RTLLPRPSEN
910 920 930 940 950
QSHNVCSFSI LSNSSVTGRG SFRPIQSSLT KAALSRPIVP KVLPPQATSH
960 970 980 990 1000
LASAIDLAAT SAGILSGNPL PALDTEGLSG ISPLSSDEVT GAISGQDSTG
1010 1020 1030 1040 1050
THQDGDTLPT VGGSDPFVSI PSRPEQEPVA DSFQGSSVLS LSELPKAPLQ
1060 1070 1080 1090 1100
NGLSIPLSSS ESSSTRLSPP DVSALLDISL PGPPEDALSQ GEPATHISDS
1110 1120 1130 1140 1150
IIEIAISSGQ YGEGVPLSPA KLNGSDSSKS LPSPSSSPQP HWIASPTHDP
1160 1170 1180 1190 1200
QWYPSDSTDS SLSSLFASFI SPEKSRKMLP TPIGTNSGTS LLGPSLLDGN
1210 1220 1230 1240 1250
SRDSFVSRSL ADVAEVVDSQ LVCMMNENSI DYISRFNDLA QELSIAEPGR
1260
REALFDGGGG GPAVSDLSQ
Length:1,269
Mass (Da):134,718
Last modified:October 5, 2010 - v3
Checksum:i16D630909A42618B
GO

Sequence cautioni

The sequence AAK61288 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAD38692 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246G → D in BAA92664 (PubMed:10718198).Curated1
Sequence conflicti503L → S in BAA92664 (PubMed:10718198).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006639 Genomic DNA. Translation: AAK61288.1. Sequence problems.
Z97652, AL031009, AL031708 Genomic DNA. Translation: CAM26431.1.
AL031009, AL031708, Z97652 Genomic DNA. Translation: CAM26477.1.
AL833832 mRNA. Translation: CAD38692.1. Sequence problems.
AB037847 mRNA. Translation: BAA92664.2.
CCDSiCCDS10440.2.
RefSeqiNP_065876.3. NM_020825.3.
UniGeneiHs.513261.
Hs.603676.

Genome annotation databases

EnsembliENST00000293925; ENSP00000293925; ENSG00000007545.
ENST00000397412; ENSP00000380559; ENSG00000007545.
GeneIDi57585.
KEGGihsa:57585.
UCSCiuc010uvh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006639 Genomic DNA. Translation: AAK61288.1. Sequence problems.
Z97652, AL031009, AL031708 Genomic DNA. Translation: CAM26431.1.
AL031009, AL031708, Z97652 Genomic DNA. Translation: CAM26477.1.
AL833832 mRNA. Translation: CAD38692.1. Sequence problems.
AB037847 mRNA. Translation: BAA92664.2.
CCDSiCCDS10440.2.
RefSeqiNP_065876.3. NM_020825.3.
UniGeneiHs.513261.
Hs.603676.

3D structure databases

ProteinModelPortaliQ96RY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121637. 12 interactors.
IntActiQ96RY5. 3 interactors.
MINTiMINT-1370680.
STRINGi9606.ENSP00000293925.

PTM databases

iPTMnetiQ96RY5.
PhosphoSitePlusiQ96RY5.

Polymorphism and mutation databases

BioMutaiCRAMP1L.
DMDMi308153609.

Proteomic databases

EPDiQ96RY5.
MaxQBiQ96RY5.
PaxDbiQ96RY5.
PeptideAtlasiQ96RY5.
PRIDEiQ96RY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293925; ENSP00000293925; ENSG00000007545.
ENST00000397412; ENSP00000380559; ENSG00000007545.
GeneIDi57585.
KEGGihsa:57585.
UCSCiuc010uvh.3. human.

Organism-specific databases

CTDi57585.
GeneCardsiCRAMP1L.
H-InvDBHIX0079831.
HIX0202241.
HGNCiHGNC:14122. CRAMP1.
HPAiHPA041752.
neXtProtiNX_Q96RY5.
OpenTargetsiENSG00000007545.
PharmGKBiPA26861.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFWT. Eukaryota.
ENOG4110SYD. LUCA.
GeneTreeiENSGT00390000003337.
HOGENOMiHOG000049034.
HOVERGENiHBG079959.
InParanoidiQ96RY5.
OMAiHWQEGGR.
OrthoDBiEOG091G050A.
PhylomeDBiQ96RY5.
TreeFamiTF328521.

Miscellaneous databases

ChiTaRSiCRAMP1L. human.
GenomeRNAii57585.
PROiQ96RY5.

Gene expression databases

BgeeiENSG00000007545.
CleanExiHS_CRAMP1L.
HS_HN1L.
ExpressionAtlasiQ96RY5. baseline and differential.
GenevisibleiQ96RY5. HS.

Family and domain databases

InterProiIPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
PROSITEiPS51293. SANT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRML_HUMAN
AccessioniPrimary (citable) accession number: Q96RY5
Secondary accession number(s): A8MZL1
, B1AJY1, Q8NDN1, Q9P2C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.