Q96RW7 (HMCN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hemicentin-1

Alternative name(s):
Fibulin-6
Short name=FIBL-6

Gene names

Name:	HMCN1
Synonyms:	FIBL6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	5635 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted › extracellular space › extracellular matrix › basement membrane By similarity.
Tissue specificity	Isoform 1 and isoform 2 are expressed in skin fibroblasts and retinal pigment epithelium (RPE) cells. Ref.5
Involvement in disease	Age-related macular degeneration 1 (ARMD1) [MIM:603075]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.5
Sequence similarities	Contains 7 EGF-like domains. Contains 44 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 nidogen G2 beta-barrel domain. Contains 6 TSP type-1 domains. Contains 1 VWFA domain.
Sequence caution	The sequence BAB71154.1 differs from that shown. Reason: Frameshift at position 657. The sequence BAB71216.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Cellular component	Basement membrane Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Age-related macular degeneration Disease mutation
Domain	EGF-like domain Immunoglobulin domain Repeat Signal
Ligand	Calcium
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	basement membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cell cortex Inferred from electronic annotation. Source: Compara cell junction Inferred from electronic annotation. Source: Compara
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96RW7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96RW7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     5315-5431: Missing.

Isoform 3 (identifier: Q96RW7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-616: Missing.
     1169-1171: VPP → GES
     1172-5635: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 5635	5614	Hemicentin-1		PRO_0000045391
Regions
	Domain	41 – 216	176	VWFA
	Domain	431 – 517	87	Ig-like C2-type 1
	Domain	520 – 607	88	Ig-like C2-type 2
	Domain	612 – 697	86	Ig-like C2-type 3
	Domain	702 – 788	87	Ig-like C2-type 4
	Domain	793 – 883	91	Ig-like C2-type 5
	Domain	890 – 976	87	Ig-like C2-type 6
	Domain	981 – 1067	87	Ig-like C2-type 7
	Domain	1072 – 1166	95	Ig-like C2-type 8
	Domain	1171 – 1255	85	Ig-like C2-type 9
	Domain	1262 – 1354	93	Ig-like C2-type 10
	Domain	1358 – 1447	90	Ig-like C2-type 11
	Domain	1452 – 1541	90	Ig-like C2-type 12
	Domain	1546 – 1634	89	Ig-like C2-type 13
	Domain	1638 – 1724	87	Ig-like C2-type 14
	Domain	1733 – 1821	89	Ig-like C2-type 15
	Domain	1826 – 1914	89	Ig-like C2-type 16
	Domain	1919 – 2007	89	Ig-like C2-type 17
	Domain	2012 – 2097	86	Ig-like C2-type 18
	Domain	2104 – 2190	87	Ig-like C2-type 19
	Domain	2195 – 2285	91	Ig-like C2-type 20
	Domain	2290 – 2379	90	Ig-like C2-type 21
	Domain	2384 – 2470	87	Ig-like C2-type 22
	Domain	2478 – 2564	87	Ig-like C2-type 23
	Domain	2571 – 2662	92	Ig-like C2-type 24
	Domain	2666 – 2763	98	Ig-like C2-type 25
	Domain	2766 – 2864	99	Ig-like C2-type 26
	Domain	2868 – 2959	92	Ig-like C2-type 27
	Domain	2964 – 3051	88	Ig-like C2-type 28
	Domain	3056 – 3146	91	Ig-like C2-type 29
	Domain	3151 – 3240	90	Ig-like C2-type 30
	Domain	3245 – 3335	91	Ig-like C2-type 31
	Domain	3340 – 3429	90	Ig-like C2-type 32
	Domain	3434 – 3516	83	Ig-like C2-type 33
	Domain	3527 – 3615	89	Ig-like C2-type 34
	Domain	3620 – 3708	89	Ig-like C2-type 35
	Domain	3713 – 3797	85	Ig-like C2-type 36
	Domain	3804 – 3892	89	Ig-like C2-type 37
	Domain	3897 – 3983	87	Ig-like C2-type 38
	Domain	3988 – 4076	89	Ig-like C2-type 39
	Domain	4079 – 4164	86	Ig-like C2-type 40
	Domain	4169 – 4255	87	Ig-like C2-type 41
	Domain	4260 – 4344	85	Ig-like C2-type 42
	Domain	4348 – 4435	88	Ig-like C2-type 43
	Domain	4440 – 4527	88	Ig-like C2-type 44
	Domain	4529 – 4584	56	TSP type-1 1
	Domain	4586 – 4641	56	TSP type-1 2
	Domain	4643 – 4698	56	TSP type-1 3
	Domain	4700 – 4755	56	TSP type-1 4
	Domain	4757 – 4812	56	TSP type-1 5
	Domain	4814 – 4869	56	TSP type-1 6
	Domain	4871 – 5093	223	Nidogen G2 beta-barrel
	Domain	5107 – 5146	40	EGF-like 1; calcium-binding Potential
	Domain	5147 – 5191	45	EGF-like 2; calcium-binding Potential
	Domain	5192 – 5229	38	EGF-like 3; calcium-binding Potential
	Domain	5230 – 5271	42	EGF-like 4; calcium-binding Potential
	Domain	5272 – 5307	36	EGF-like 5; calcium-binding Potential
	Domain	5315 – 5355	41	EGF-like 6; calcium-binding Potential
	Domain	5432 – 5471	40	EGF-like 7; calcium-binding Potential
Amino acid modifications
	Glycosylation	349	1	N-linked (GlcNAc...) Potential
	Glycosylation	390	1	N-linked (GlcNAc...) Potential
	Glycosylation	528	1	N-linked (GlcNAc...) Potential
	Glycosylation	550	1	N-linked (GlcNAc...) Potential
	Glycosylation	573	1	N-linked (GlcNAc...) Potential
	Glycosylation	620	1	N-linked (GlcNAc...) Potential
	Glycosylation	693	1	N-linked (GlcNAc...) Potential
	Glycosylation	809	1	N-linked (GlcNAc...) Potential
	Glycosylation	970	1	N-linked (GlcNAc...) Potential
	Glycosylation	1158	1	N-linked (GlcNAc...) Potential
	Glycosylation	1272	1	N-linked (GlcNAc...) Potential
	Glycosylation	1369	1	N-linked (GlcNAc...) Potential
	Glycosylation	1552	1	N-linked (GlcNAc...) Potential
	Glycosylation	1929	1	N-linked (GlcNAc...) Potential
	Glycosylation	2112	1	N-linked (GlcNAc...) Potential
	Glycosylation	2155	1	N-linked (GlcNAc...) Potential
	Glycosylation	2395	1	N-linked (GlcNAc...) Potential
	Glycosylation	2689	1	N-linked (GlcNAc...) Potential
	Glycosylation	2887	1	N-linked (GlcNAc...) Potential
	Glycosylation	2973	1	N-linked (GlcNAc...) Potential
	Glycosylation	3221	1	N-linked (GlcNAc...) Potential
	Glycosylation	3300	1	N-linked (GlcNAc...) Potential
	Glycosylation	3530	1	N-linked (GlcNAc...) Potential
	Glycosylation	3689	1	N-linked (GlcNAc...) Potential
	Glycosylation	3727	1	N-linked (GlcNAc...) Potential
	Glycosylation	3812	1	N-linked (GlcNAc...) Potential
	Glycosylation	4029	1	N-linked (GlcNAc...) Potential
	Glycosylation	4401	1	N-linked (GlcNAc...) Potential
	Glycosylation	4491	1	N-linked (GlcNAc...) Potential
	Glycosylation	4606	1	N-linked (GlcNAc...) Potential
	Glycosylation	4894	1	N-linked (GlcNAc...) Potential
	Glycosylation	5040	1	N-linked (GlcNAc...) Potential
	Glycosylation	5267	1	N-linked (GlcNAc...) Potential
	Glycosylation	5615	1	N-linked (GlcNAc...) Potential
	Disulfide bond	451 ↔ 499		By similarity
	Disulfide bond	541 ↔ 591		By similarity
	Disulfide bond	633 ↔ 681		By similarity
	Disulfide bond	723 ↔ 772		By similarity
	Disulfide bond	814 ↔ 867		By similarity
	Disulfide bond	911 ↔ 960		By similarity
	Disulfide bond	1002 ↔ 1051		By similarity
	Disulfide bond	1101 ↔ 1150		By similarity
	Disulfide bond	1192 ↔ 1241		By similarity
	Disulfide bond	1288 ↔ 1338		By similarity
	Disulfide bond	1382 ↔ 1431		By similarity
	Disulfide bond	1475 ↔ 1525		By similarity
	Disulfide bond	1569 ↔ 1618		By similarity
	Disulfide bond	1663 ↔ 1712		By similarity
	Disulfide bond	1756 ↔ 1805		By similarity
	Disulfide bond	1848 ↔ 1898		By similarity
	Disulfide bond	1942 ↔ 1991		By similarity
	Disulfide bond	2033 ↔ 2083		By similarity
	Disulfide bond	2125 ↔ 2174		By similarity
	Disulfide bond	2218 ↔ 2269		By similarity
	Disulfide bond	2314 ↔ 2363		By similarity
	Disulfide bond	2408 ↔ 2457		By similarity
	Disulfide bond	2501 ↔ 2550		By similarity
	Disulfide bond	2597 ↔ 2646		By similarity
	Disulfide bond	2696 ↔ 2745		By similarity
	Disulfide bond	2799 ↔ 2848		By similarity
	Disulfide bond	2894 ↔ 2943		By similarity
	Disulfide bond	2986 ↔ 3035		By similarity
	Disulfide bond	3081 ↔ 3130		By similarity
	Disulfide bond	3173 ↔ 3224		By similarity
	Disulfide bond	3268 ↔ 3319		By similarity
	Disulfide bond	3364 ↔ 3413		By similarity
	Disulfide bond	3457 ↔ 3506		By similarity
	Disulfide bond	3550 ↔ 3599		By similarity
	Disulfide bond	3643 ↔ 3692		By similarity
	Disulfide bond	3734 ↔ 3783		By similarity
	Disulfide bond	3825 ↔ 3876		By similarity
	Disulfide bond	3918 ↔ 3967		By similarity
	Disulfide bond	4009 ↔ 4058		By similarity
	Disulfide bond	4100 ↔ 4148		By similarity
	Disulfide bond	4190 ↔ 4239		By similarity
	Disulfide bond	4281 ↔ 4328		By similarity
	Disulfide bond	4371 ↔ 4419		By similarity
	Disulfide bond	4461 ↔ 4509		By similarity
	Disulfide bond	4541 ↔ 4578		By similarity
	Disulfide bond	4545 ↔ 4583		By similarity
	Disulfide bond	4556 ↔ 4568		By similarity
	Disulfide bond	4598 ↔ 4635		By similarity
	Disulfide bond	4602 ↔ 4640		By similarity
	Disulfide bond	4613 ↔ 4625		By similarity
	Disulfide bond	4655 ↔ 4692		By similarity
	Disulfide bond	4659 ↔ 4697		By similarity
	Disulfide bond	4670 ↔ 4682		By similarity
	Disulfide bond	4712 ↔ 4749		By similarity
	Disulfide bond	4716 ↔ 4754		By similarity
	Disulfide bond	4727 ↔ 4739		By similarity
	Disulfide bond	4769 ↔ 4806		By similarity
	Disulfide bond	4773 ↔ 4811		By similarity
	Disulfide bond	4784 ↔ 4796		By similarity
	Disulfide bond	4826 ↔ 4863		By similarity
	Disulfide bond	4830 ↔ 4868		By similarity
	Disulfide bond	4841 ↔ 4853		By similarity
	Disulfide bond	5111 ↔ 5121		By similarity
	Disulfide bond	5117 ↔ 5130		By similarity
	Disulfide bond	5132 ↔ 5145		By similarity
	Disulfide bond	5196 ↔ 5206		By similarity
	Disulfide bond	5202 ↔ 5215		By similarity
	Disulfide bond	5217 ↔ 5228		By similarity
	Disulfide bond	5276 ↔ 5289		By similarity
	Disulfide bond	5283 ↔ 5298		By similarity
	Disulfide bond	5319 ↔ 5330		By similarity
	Disulfide bond	5326 ↔ 5339		By similarity
	Disulfide bond	5341 ↔ 5354		By similarity
	Disulfide bond	5436 ↔ 5446		By similarity
	Disulfide bond	5442 ↔ 5455		By similarity
	Disulfide bond	5457 ↔ 5470		By similarity
Natural variations
	Alternative sequence	1 – 616	616	Missing in isoform 3.		VSP_016871
	Alternative sequence	1169 – 1171	3	VPP → GES in isoform 3.		VSP_016872
	Alternative sequence	1172 – 5635	4464	Missing in isoform 3.		VSP_016873
	Alternative sequence	5315 – 5431	117	Missing in isoform 2.		VSP_016874
	Natural variant	1056	1	T → A. Corresponds to variant rs7539719 [ dbSNP | Ensembl ].		VAR_049875
	Natural variant	1184	1	V → F. Corresponds to variant rs12239296 [ dbSNP | Ensembl ].		VAR_049876
	Natural variant	1624	1	A → V. Ref.5		VAR_024811
	Natural variant	2327	1	M → I. Ref.5 Corresponds to variant rs12067376 [ dbSNP | Ensembl ].		VAR_024812
	Natural variant	2418	1	I → T. Ref.1 Ref.5 Corresponds to variant rs12129650 [ dbSNP | Ensembl ].		VAR_024813
	Natural variant	2893	1	E → G. Ref.5 Corresponds to variant rs10798035 [ dbSNP | Ensembl ].		VAR_024814
	Natural variant	4084	1	H → Y. Ref.5 Corresponds to variant rs41317489 [ dbSNP | Ensembl ].		VAR_024815
	Natural variant	4437	1	Q → R. Corresponds to variant rs10911825 [ dbSNP | Ensembl ].		VAR_049877
	Natural variant	4720	1	A → T. Ref.5 Corresponds to variant rs6693069 [ dbSNP | Ensembl ].		VAR_024816
	Natural variant	5087	1	D → V. Ref.5 Corresponds to variant rs41317507 [ dbSNP | Ensembl ].		VAR_024817
	Natural variant	5345	1	Q → R in ARMD1. Ref.5		VAR_024818
Experimental info
	Sequence conflict	35	1	I → F Ref.1
	Sequence conflict	483	1	N → S Ref.1
	Sequence conflict	1042	1	G → E Ref.1
	Sequence conflict	1078	1	Q → L Ref.1
	Sequence conflict	1153	1	T → I in BAB71216. Ref.2
	Sequence conflict	1319	1	D → E Ref.1
	Sequence conflict	1368	1	T → S Ref.1
	Sequence conflict	1414	1	K → R in BAB71216. Ref.2
	Sequence conflict	1461	1	N → K Ref.1
	Sequence conflict	1570	1	E → K Ref.1
	Sequence conflict	1664	1	K → N Ref.1
	Sequence conflict	1688	1	I → F Ref.1
	Sequence conflict	1775	1	I → V in BAB71216. Ref.2
	Sequence conflict	1816	1	K → E in BAB71216. Ref.2
	Sequence conflict	1959	1	R → C Ref.1
	Sequence conflict	2073	1	A → T Ref.1
	Sequence conflict	2184	1	E → EK Ref.1
	Sequence conflict	2872	1	K → E Ref.1
	Sequence conflict	3189	1	H → Y Ref.1
	Sequence conflict	3355	1	L → Y Ref.1
	Sequence conflict	4136	1	A → T Ref.4
	Sequence conflict	4340	1	I → T Ref.1
	Sequence conflict	4358	1	N → H Ref.4
	Sequence conflict	4699	1	I → V Ref.4
	Sequence conflict	5294	1	G → S Ref.1
	Sequence conflict	5317	1	N → D Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: 19AE01E5E2A27E2A	FASTA	5,635	613,390
	10 20 30 40 50 60 MISWEVVHTV FLFALLYSSL AQDASPQSEI RAEEIPEGAS TLAFVFDVTG SMYDDLVQVI 70 80 90 100 110 120 EGASKILETS LKRPKRPLFN FALVPFHDPE IGPVTITTDP KKFQYELREL YVQGGGDCPE 130 140 150 160 170 180 MSIGAIKIAL EISLPGSFIY VFTDARSKDY RLTHEVLQLI QQKQSQVVFV LTGDCDDRTH 190 200 210 220 230 240 IGYKVYEEIA STSSGQVFHL DKKQVNEVLK WVEEAVQASK VHLLSTDHLE QAVNTWRIPF 250 260 270 280 290 300 DPSLKEVTVS LSGPSPMIEI RNPLGKLIKK GFGLHELLNI HNSAKVVNVK EPEAGMWTVK 310 320 330 340 350 360 TSSSGRHSVR ITGLSTIDFR AGFSRKPTLD FKKTVSRPVQ GIPTYVLLNT SGISTPARID 370 380 390 400 410 420 LLELLSISGS SLKTIPVKYY PHRKPYGIWN ISDFVPPNEA FFLKVTGYDK DDYLFQRVSS 430 440 450 460 470 480 VSFSSIVPDA PKVTMPEKTP GYYLQPGQIP CSVDSLLPFT LSFVRNGVTL GVDQYLKESA 490 500 510 520 530 540 SVNLDIAKVT LSDEGFYECI AVSSAGTGRA QTFFDVSEPP PVIQVPNNVT VTPGERAVLT 550 560 570 580 590 600 CLIISAVDYN LTWQRNDRDV RLAEPARIRT LANLSLELKS VKFNDAGEYH CMVSSEGGSS 610 620 630 640 650 660 AASVFLTVQE PPKVTVMPKN QSFTGGSEVS IMCSATGYPK PKIAWTVNDM FIVGSHRYRM 670 680 690 700 710 720 TSDGTLFIKN AAPKDAGIYG CLASNSAGTD KQNSTLRYIE APKLMVVQSE LLVALGDITV 730 740 750 760 770 780 MECKTSGIPP PQVKWFKGDL ELRPSTFLII DPLLGLLKIQ ETQDLDAGDY TCVAINEAGR 790 800 810 820 830 840 ATGKITLDVG SPPVFIQEPA DVSMEIGSNV TLPCYVQGYP EPTIKWRRLD NMPIFSRPFS 850 860 870 880 890 900 VSSISQLRTG ALFILNLWAS DKGTYICEAE NQFGKIQSET TVTVTGLVAP LIGISPSVAN 910 920 930 940 950 960 VIEGQQLTLP CTLLAGNPIP ERRWIKNSAM LLQNPYITVR SDGSLHIERV QLQDGGEYTC 970 980 990 1000 1010 1020 VASNVAGTNN KTTSVVVHVL PTIQHGQQIL STIEGIPVTL PCKASGNPKP SVIWSKKGEL 1030 1040 1050 1060 1070 1080 ISTSSAKFSA GADGSLYVVS PGGEESGEYV CTATNTAGYA KRKVQLTVYV RPRVFGDQRG 1090 1100 1110 1120 1130 1140 LSQDKPVEIS VLAGEEVTLP CEVKSLPPPI ITWAKETQLI SPFSPRHTFL PSGSMKITET 1150 1160 1170 1180 1190 1200 RTSDSGMYLC VATNIAGNVT QAVKLNVHVP PKIQRGPKHL KVQVGQRVDI PCNAQGTPLP 1210 1220 1230 1240 1250 1260 VITWSKGGST MLVDGEHHVS NPDGTLSIDQ ATPSDAGIYT CVATNIAGTD ETEITLHVQE 1270 1280 1290 1300 1310 1320 PPTVEDLEPP YNTTFQERVA NQRIEFPCPA KGTPKPTIKW LHNGRELTGR EPGISILEDG 1330 1340 1350 1360 1370 1380 TLLVIASVTP YDNGEYICVA VNEAGTTERK YNLKVHVPPV IKDKEQVTNV SVLLNQLTNL 1390 1400 1410 1420 1430 1440 FCEVEGTPSP IIMWYKDNVQ VTESSTIQTV NNGKILKLFR ATPEDAGRYS CKAINIAGTS 1450 1460 1470 1480 1490 1500 QKYFNIDVLV PPTIIGTNFP NEVSVVLNRD VALECQVKGT PFPDIHWFKD GKPLFLGDPN 1510 1520 1530 1540 1550 1560 VELLDRGQVL HLKNARRNDK GRYQCTVSNA AGKQAKDIKL TIYIPPSIKG GNVTTDISVL 1570 1580 1590 1600 1610 1620 INSLIKLECE TRGLPMPAIT WYKDGQPIMS SSQALYIDKG QYLHIPRAQV SDSATYTCHV 1630 1640 1650 1660 1670 1680 ANVAGTAEKS FHVDVYVPPM IEGNLATPLN KQVVIAHSLT LECKAAGNPS PILTWLKDGV 1690 1700 1710 1720 1730 1740 PVKANDNIRI EAGGKKLEIM SAQEIDRGQY ICVATSVAGE KEIKYEVDVL VPPAIEGGDE 1750 1760 1770 1780 1790 1800 TSYFIVMVNN LLELDCHVTG SPPPTIMWLK DGQLIDERDG FKILLNGRKL VIAQAQVSNT 1810 1820 1830 1840 1850 1860 GLYRCMAANT AGDHKKEFEV TVHVPPTIKS SGLSERVVVK YKPVALQCIA NGIPNPSITW 1870 1880 1890 1900 1910 1920 LKDDQPVNTA QGNLKIQSSG RVLQIAKTLL EDAGRYTCVA TNAAGETQQH IQLHVHEPPS 1930 1940 1950 1960 1970 1980 LEDAGKMLNE TVLVSNPVQL ECKAAGNPVP VITWYKDNRL LSGSTSMTFL NRGQIIDIES 1990 2000 2010 2020 2030 2040 AQISDAGIYK CVAINSAGAT ELFYSLQVHV APSISGSNNM VAVVVNNPVR LECEARGIPA 2050 2060 2070 2080 2090 2100 PSLTWLKDGS PVSSFSNGLQ VLSGGRILAL TSAQISDTGR YTCVAVNAAG EKQRDIDLRV 2110 2120 2130 2140 2150 2160 YVPPNIMGEE QNVSVLISQA VELLCQSDAI PPPTLTWLKD GHPLLKKPGL SISENRSVLK 2170 2180 2190 2200 2210 2220 IEDAQVQDTG RYTCEATNVA GKTEKNYNVN IWVPPNIGGS DELTQLTVIE GNLISLLCES 2230 2240 2250 2260 2270 2280 SGIPPPNLIW KKKGSPVLTD SMGRVRILSG GRQLQISIAE KSDAALYSCV ASNVAGTAKK 2290 2300 2310 2320 2330 2340 EYNLQVYIRP TITNSGSHPT EIIVTRGKSI SLECEVQGIP PPTVTWMKDG HPLIKAKGVE 2350 2360 2370 2380 2390 2400 ILDEGHILQL KNIHVSDTGR YVCVAVNVAG MTDKKYDLSV HAPPSIIGNH RSPENISVVE 2410 2420 2430 2440 2450 2460 KNSVSLTCEA SGIPLPSITW FKDGWPVSLS NSVRILSGGR MLRLMQTTME DAGQYTCVVR 2470 2480 2490 2500 2510 2520 NAAGEERKIF GLSVLVPPHI VGENTLEDVK VKEKQSVTLT CEVTGNPVPE ITWHKDGQPL 2530 2540 2550 2560 2570 2580 QEDEAHHIIS GGRFLQITNV QVPHTGRYTC LASSPAGHKS RSFSLNVFVS PTIAGVGSDG 2590 2600 2610 2620 2630 2640 NPEDVTVILN SPTSLVCEAY SYPPATITWF KDGTPLESNR NIRILPGGRT LQILNAQEDN 2650 2660 2670 2680 2690 2700 AGRYSCVATN EAGEMIKHYE VKVYIPPIIN KGDLWGPGLS PKEVKIKVNN TLTLECEAYA 2710 2720 2730 2740 2750 2760 IPSASLSWYK DGQPLKSDDH VNIAANGHTL QIKEAQISDT GRYTCVASNI AGEDELDFDV 2770 2780 2790 2800 2810 2820 NIQVPPSFQK LWEIGNMLDT GRNGEAKDVI INNPISLYCE TNAAPPPTLT WYKDGHPLTS 2830 2840 2850 2860 2870 2880 SDKVLILPGG RVLQIPRAKV EDAGRYTCVA VNEAGEDSLQ YDVRVLVPPI IKGANSDLPE 2890 2900 2910 2920 2930 2940 EVTVLVNKSA LIECLSSGSP APRNSWQKDG QPLLEDDHHK FLSNGRILQI LNTQITDIGR 2950 2960 2970 2980 2990 3000 YVCVAENTAG SAKKYFNLNV HVPPSVIGPK SENLTVVVNN FISLTCEVSG FPPPDLSWLK 3010 3020 3030 3040 3050 3060 NEQPIKLNTN TLIVPGGRTL QIIRAKVSDG GEYTCIAINQ AGESKKKFSL TVYVPPSIKD 3070 3080 3090 3100 3110 3120 HDSESLSVVN VREGTSVSLE CESNAVPPPV ITWYKNGRMI TESTHVEILA DGQMLHIKKA 3130 3140 3150 3160 3170 3180 EVSDTGQYVC RAINVAGRDD KNFHLNVYVP PSIEGPEREV IVETISNPVT LTCDATGIPP 3190 3200 3210 3220 3230 3240 PTIAWLKNHK RIENSDSLEV RILSGGSKLQ IARSQHSDSG NYTCIASNME GKAQKYYFLS 3250 3260 3270 3280 3290 3300 IQVPPSVAGA EIPSDVSVLL GENVELVCNA NGIPTPLIQW LKDGKPIASG ETERIRVSAN 3310 3320 3330 3340 3350 3360 GSTLNIYGAL TSDTGKYTCV ATNPAGEEDR IFNLNVYVTP TIRGNKDEAE KLMTLVDTSI 3370 3380 3390 3400 3410 3420 NIECRATGTP PPQINWLKNG LPLPLSSHIR LLAAGQVIRI VRAQVSDVAV YTCVASNRAG 3430 3440 3450 3460 3470 3480 VDNKHYNLQV FAPPNMDNSM GTEEITVLKG SSTSMACITD GTPAPSMAWL RDGQPLGLDA 3490 3500 3510 3520 3530 3540 HLTVSTHGMV LQLLKAETED SGKYTCIASN EAGEVSKHFI LKVLEPPHIN GSEEHEEISV 3550 3560 3570 3580 3590 3600 IVNNPLELTC IASGIPAPKM TWMKDGRPLP QTDQVQTLGG GEVLRISTAQ VEDTGRYTCL 3610 3620 3630 3640 3650 3660 ASSPAGDDDK EYLVRVHVPP NIAGTDEPRD ITVLRNRQVT LECKSDAVPP PVITWLRNGE 3670 3680 3690 3700 3710 3720 RLQATPRVRI LSGGRYLQIN NADLGDTANY TCVASNIAGK TTREFILTVN VPPNIKGGPQ 3730 3740 3750 3760 3770 3780 SLVILLNKST VLECIAEGVP TPRITWRKDG AVLAGNHARY SILENGFLHI QSAHVTDTGR 3790 3800 3810 3820 3830 3840 YLCMATNAAG TDRRRIDLQV HVPPSIAPGP TNMTVIVNVQ TTLACEATGI PKPSINWRKN 3850 3860 3870 3880 3890 3900 GHLLNVDQNQ NSYRLLSSGS LVIISPSVDD TATYECTVTN GAGDDKRTVD LTVQVPPSIA 3910 3920 3930 3940 3950 3960 DEPTDFLVTK HAPAVITCTA SGVPFPSIHW TKNGIRLLPR GDGYRILSSG AIEILATQLN 3970 3980 3990 4000 4010 4020 HAGRYTCVAR NAAGSAHRHV TLHVHEPPVI QPQPSELHVI LNNPILLPCE ATGTPSPFIT 4030 4040 4050 4060 4070 4080 WQKEGINVNT SGRNHAVLPS GGLQISRAVR EDAGTYMCVA QNPAGTALGK IKLNVQVPPV 4090 4100 4110 4120 4130 4140 ISPHLKEYVI AVDKPITLSC EADGLPPPDI TWHKDGRAIV ESIRQRVLSS GSLQIAFVQP 4150 4160 4170 4180 4190 4200 GDAGHYTCMA ANVAGSSSTS TKLTVHVPPR IRSTEGHYTV NENSQAILPC VADGIPTPAI 4210 4220 4230 4240 4250 4260 NWKKDNVLLA NLLGKYTAEP YGELILENVV LEDSGFYTCV ANNAAGEDTH TVSLTVHVLP 4270 4280 4290 4300 4310 4320 TFTELPGDVS LNKGEQLRLS CKATGIPLPK LTWTFNNNII PAHFDSVNGH SELVIERVSK 4330 4340 4350 4360 4370 4380 EDSGTYVCTA ENSVGFVKAI GFVYVKEPPV FKGDYPSNWI EPLGGNAILN CEVKGDPTPT 4390 4400 4410 4420 4430 4440 IQWNRKGVDI EISHRIRQLG NGSLAIYGTV NEDAGDYTCV ATNEAGVVER SMSLTLQSPP 4450 4460 4470 4480 4490 4500 IITLEPVETV INAGGKIILN CQATGEPQPT ITWSRQGHSI SWDDRVNVLS NNSLYIADAQ 4510 4520 4530 4540 4550 4560 KEDTSEFECV ARNLMGSVLV RVPVIVQVHG GFSQWSAWRA CSVTCGKGIQ KRSRLCNQPL 4570 4580 4590 4600 4610 4620 PANGGKPCQG SDLEMRNCQN KPCPVDGSWS EWSLWEECTR SCGRGNQTRT RTCNNPSVQH 4630 4640 4650 4660 4670 4680 GGRPCEGNAV EIIMCNIRPC PVHGAWSAWQ PWGTCSESCG KGTQTRARLC NNPPPAFGGS 4690 4700 4710 4720 4730 4740 YCDGAETQMQ VCNERNCPIH GKWATWASWS ACSVSCGGGA RQRTRGCSDP VPQYGGRKCE 4750 4760 4770 4780 4790 4800 GSDVQSDFCN SDPCPTHGNW SPWSGWGTCS RTCNGGQMRR YRTCDNPPPS NGGRACGGPD 4810 4820 4830 4840 4850 4860 SQIQRCNTDM CPVDGSWGSW HSWSQCSASC GGGEKTRKRL CDHPVPVKGG RPCPGDTTQV 4870 4880 4890 4900 4910 4920 TRCNVQACPG GPQRARGSVI GNINDVEFGI AFLNATITDS PNSDTRIIRA KITNVPRSLG 4930 4940 4950 4960 4970 4980 SAMRKIVSIL NPIYWTTAKE IGEAVNGFTL TNAVFKRETQ VEFATGEILQ MSHIARGLDS 4990 5000 5010 5020 5030 5040 DGSLLLDIVV SGYVLQLQSP AEVTVKDYTE DYIQTGPGQL YAYSTRLFTI DGISIPYTWN 5050 5060 5070 5080 5090 5100 HTVFYDQAQG RMPFLVETLH ASSVESDYNQ IEETLGFKIH ASISKGDRSN QCPSGFTLDS 5110 5120 5130 5140 5150 5160 VGPFCADEDE CAAGNPCSHS CHNAMGTYYC SCPKGLTIAA DGRTCQDIDE CALGRHTCHA 5170 5180 5190 5200 5210 5220 GQDCDNTIGS YRCVVRCGSG FRRTSDGLSC QDINECQESS PCHQRCFNAI GSFHCGCEPG 5230 5240 5250 5260 5270 5280 YQLKGRKCMD VNECRQNVCR PDQHCKNTRG GYKCIDLCPN GMTKAENGTC IDIDECKDGT 5290 5300 5310 5320 5330 5340 HQCRYNQICE NTRGSYRCVC PRGYRSQGVG RPCMDINECE QVPKPCAHQC SNTPGSFKCI 5350 5360 5370 5380 5390 5400 CPPGQHLLGD GKSCAGLERL PNYGTQYSSY NLARFSPVRN NYQPQQHYRQ YSHLYSSYSE 5410 5420 5430 5440 5450 5460 YRNSRTSLSR TRRTIRKTCP EGSEASHDTC VDIDECENTD ACQHECKNTF GSYQCICPPG 5470 5480 5490 5500 5510 5520 YQLTHNGKTC QDIDECLEQN VHCGPNRMCF NMRGSYQCID TPCPPNYQRD PVSGFCLKNC 5530 5540 5550 5560 5570 5580 PPNDLECALS PYALEYKLVS LPFGIATNQD LIRLVAYTQD GVMHPRTTFL MVDEEQTVPF 5590 5600 5610 5620 5630 ALRDENLKGV VYTTRPLREA ETYRMRVRAS SYSANGTIEY QTTFIVYIAV SAYPY
	Isoform 2 [UniParc]. Checksum: D3071680F944D366	FASTA	5,518	600,097
	10 20 30 40 50 60 MISWEVVHTV FLFALLYSSL AQDASPQSEI RAEEIPEGAS TLAFVFDVTG SMYDDLVQVI 70 80 90 100 110 120 EGASKILETS LKRPKRPLFN FALVPFHDPE IGPVTITTDP KKFQYELREL YVQGGGDCPE 130 140 150 160 170 180 MSIGAIKIAL EISLPGSFIY VFTDARSKDY RLTHEVLQLI QQKQSQVVFV LTGDCDDRTH 190 200 210 220 230 240 IGYKVYEEIA STSSGQVFHL DKKQVNEVLK WVEEAVQASK VHLLSTDHLE QAVNTWRIPF 250 260 270 280 290 300 DPSLKEVTVS LSGPSPMIEI RNPLGKLIKK GFGLHELLNI HNSAKVVNVK EPEAGMWTVK 310 320 330 340 350 360 TSSSGRHSVR ITGLSTIDFR AGFSRKPTLD FKKTVSRPVQ GIPTYVLLNT SGISTPARID 370 380 390 400 410 420 LLELLSISGS SLKTIPVKYY PHRKPYGIWN ISDFVPPNEA FFLKVTGYDK DDYLFQRVSS 430 440 450 460 470 480 VSFSSIVPDA PKVTMPEKTP GYYLQPGQIP CSVDSLLPFT LSFVRNGVTL GVDQYLKESA 490 500 510 520 530 540 SVNLDIAKVT LSDEGFYECI AVSSAGTGRA QTFFDVSEPP PVIQVPNNVT VTPGERAVLT 550 560 570 580 590 600 CLIISAVDYN LTWQRNDRDV RLAEPARIRT LANLSLELKS VKFNDAGEYH CMVSSEGGSS 610 620 630 640 650 660 AASVFLTVQE PPKVTVMPKN QSFTGGSEVS IMCSATGYPK PKIAWTVNDM FIVGSHRYRM 670 680 690 700 710 720 TSDGTLFIKN AAPKDAGIYG CLASNSAGTD KQNSTLRYIE APKLMVVQSE LLVALGDITV 730 740 750 760 770 780 MECKTSGIPP PQVKWFKGDL ELRPSTFLII DPLLGLLKIQ ETQDLDAGDY TCVAINEAGR 790 800 810 820 830 840 ATGKITLDVG SPPVFIQEPA DVSMEIGSNV TLPCYVQGYP EPTIKWRRLD NMPIFSRPFS 850 860 870 880 890 900 VSSISQLRTG ALFILNLWAS DKGTYICEAE NQFGKIQSET TVTVTGLVAP LIGISPSVAN 910 920 930 940 950 960 VIEGQQLTLP CTLLAGNPIP ERRWIKNSAM LLQNPYITVR SDGSLHIERV QLQDGGEYTC 970 980 990 1000 1010 1020 VASNVAGTNN KTTSVVVHVL PTIQHGQQIL STIEGIPVTL PCKASGNPKP SVIWSKKGEL 1030 1040 1050 1060 1070 1080 ISTSSAKFSA GADGSLYVVS PGGEESGEYV CTATNTAGYA KRKVQLTVYV RPRVFGDQRG 1090 1100 1110 1120 1130 1140 LSQDKPVEIS VLAGEEVTLP CEVKSLPPPI ITWAKETQLI SPFSPRHTFL PSGSMKITET 1150 1160 1170 1180 1190 1200 RTSDSGMYLC VATNIAGNVT QAVKLNVHVP PKIQRGPKHL KVQVGQRVDI PCNAQGTPLP 1210 1220 1230 1240 1250 1260 VITWSKGGST MLVDGEHHVS NPDGTLSIDQ ATPSDAGIYT CVATNIAGTD ETEITLHVQE 1270 1280 1290 1300 1310 1320 PPTVEDLEPP YNTTFQERVA NQRIEFPCPA KGTPKPTIKW LHNGRELTGR EPGISILEDG 1330 1340 1350 1360 1370 1380 TLLVIASVTP YDNGEYICVA VNEAGTTERK YNLKVHVPPV IKDKEQVTNV SVLLNQLTNL 1390 1400 1410 1420 1430 1440 FCEVEGTPSP IIMWYKDNVQ VTESSTIQTV NNGKILKLFR ATPEDAGRYS CKAINIAGTS 1450 1460 1470 1480 1490 1500 QKYFNIDVLV PPTIIGTNFP NEVSVVLNRD VALECQVKGT PFPDIHWFKD GKPLFLGDPN 1510 1520 1530 1540 1550 1560 VELLDRGQVL HLKNARRNDK GRYQCTVSNA AGKQAKDIKL TIYIPPSIKG GNVTTDISVL 1570 1580 1590 1600 1610 1620 INSLIKLECE TRGLPMPAIT WYKDGQPIMS SSQALYIDKG QYLHIPRAQV SDSATYTCHV 1630 1640 1650 1660 1670 1680 ANVAGTAEKS FHVDVYVPPM IEGNLATPLN KQVVIAHSLT LECKAAGNPS PILTWLKDGV 1690 1700 1710 1720 1730 1740 PVKANDNIRI EAGGKKLEIM SAQEIDRGQY ICVATSVAGE KEIKYEVDVL VPPAIEGGDE 1750 1760 1770 1780 1790 1800 TSYFIVMVNN LLELDCHVTG SPPPTIMWLK DGQLIDERDG FKILLNGRKL VIAQAQVSNT 1810 1820 1830 1840 1850 1860 GLYRCMAANT AGDHKKEFEV TVHVPPTIKS SGLSERVVVK YKPVALQCIA NGIPNPSITW 1870 1880 1890 1900 1910 1920 LKDDQPVNTA QGNLKIQSSG RVLQIAKTLL EDAGRYTCVA TNAAGETQQH IQLHVHEPPS 1930 1940 1950 1960 1970 1980 LEDAGKMLNE TVLVSNPVQL ECKAAGNPVP VITWYKDNRL LSGSTSMTFL NRGQIIDIES 1990 2000 2010 2020 2030 2040 AQISDAGIYK CVAINSAGAT ELFYSLQVHV APSISGSNNM VAVVVNNPVR LECEARGIPA 2050 2060 2070 2080 2090 2100 PSLTWLKDGS PVSSFSNGLQ VLSGGRILAL TSAQISDTGR YTCVAVNAAG EKQRDIDLRV 2110 2120 2130 2140 2150 2160 YVPPNIMGEE QNVSVLISQA VELLCQSDAI PPPTLTWLKD GHPLLKKPGL SISENRSVLK 2170 2180 2190 2200 2210 2220 IEDAQVQDTG RYTCEATNVA GKTEKNYNVN IWVPPNIGGS DELTQLTVIE GNLISLLCES 2230 2240 2250 2260 2270 2280 SGIPPPNLIW KKKGSPVLTD SMGRVRILSG GRQLQISIAE KSDAALYSCV ASNVAGTAKK 2290 2300 2310 2320 2330 2340 EYNLQVYIRP TITNSGSHPT EIIVTRGKSI SLECEVQGIP PPTVTWMKDG HPLIKAKGVE 2350 2360 2370 2380 2390 2400 ILDEGHILQL KNIHVSDTGR YVCVAVNVAG MTDKKYDLSV HAPPSIIGNH RSPENISVVE 2410 2420 2430 2440 2450 2460 KNSVSLTCEA SGIPLPSITW FKDGWPVSLS NSVRILSGGR MLRLMQTTME DAGQYTCVVR 2470 2480 2490 2500 2510 2520 NAAGEERKIF GLSVLVPPHI VGENTLEDVK VKEKQSVTLT CEVTGNPVPE ITWHKDGQPL 2530 2540 2550 2560 2570 2580 QEDEAHHIIS GGRFLQITNV QVPHTGRYTC LASSPAGHKS RSFSLNVFVS PTIAGVGSDG 2590 2600 2610 2620 2630 2640 NPEDVTVILN SPTSLVCEAY SYPPATITWF KDGTPLESNR NIRILPGGRT LQILNAQEDN 2650 2660 2670 2680 2690 2700 AGRYSCVATN EAGEMIKHYE VKVYIPPIIN KGDLWGPGLS PKEVKIKVNN TLTLECEAYA 2710 2720 2730 2740 2750 2760 IPSASLSWYK DGQPLKSDDH VNIAANGHTL QIKEAQISDT GRYTCVASNI AGEDELDFDV 2770 2780 2790 2800 2810 2820 NIQVPPSFQK LWEIGNMLDT GRNGEAKDVI INNPISLYCE TNAAPPPTLT WYKDGHPLTS 2830 2840 2850 2860 2870 2880 SDKVLILPGG RVLQIPRAKV EDAGRYTCVA VNEAGEDSLQ YDVRVLVPPI IKGANSDLPE 2890 2900 2910 2920 2930 2940 EVTVLVNKSA LIECLSSGSP APRNSWQKDG QPLLEDDHHK FLSNGRILQI LNTQITDIGR 2950 2960 2970 2980 2990 3000 YVCVAENTAG SAKKYFNLNV HVPPSVIGPK SENLTVVVNN FISLTCEVSG FPPPDLSWLK 3010 3020 3030 3040 3050 3060 NEQPIKLNTN TLIVPGGRTL QIIRAKVSDG GEYTCIAINQ AGESKKKFSL TVYVPPSIKD 3070 3080 3090 3100 3110 3120 HDSESLSVVN VREGTSVSLE CESNAVPPPV ITWYKNGRMI TESTHVEILA DGQMLHIKKA 3130 3140 3150 3160 3170 3180 EVSDTGQYVC RAINVAGRDD KNFHLNVYVP PSIEGPEREV IVETISNPVT LTCDATGIPP 3190 3200 3210 3220 3230 3240 PTIAWLKNHK RIENSDSLEV RILSGGSKLQ IARSQHSDSG NYTCIASNME GKAQKYYFLS 3250 3260 3270 3280 3290 3300 IQVPPSVAGA EIPSDVSVLL GENVELVCNA NGIPTPLIQW LKDGKPIASG ETERIRVSAN 3310 3320 3330 3340 3350 3360 GSTLNIYGAL TSDTGKYTCV ATNPAGEEDR IFNLNVYVTP TIRGNKDEAE KLMTLVDTSI 3370 3380 3390 3400 3410 3420 NIECRATGTP PPQINWLKNG LPLPLSSHIR LLAAGQVIRI VRAQVSDVAV YTCVASNRAG 3430 3440 3450 3460 3470 3480 VDNKHYNLQV FAPPNMDNSM GTEEITVLKG SSTSMACITD GTPAPSMAWL RDGQPLGLDA 3490 3500 3510 3520 3530 3540 HLTVSTHGMV LQLLKAETED SGKYTCIASN EAGEVSKHFI LKVLEPPHIN GSEEHEEISV 3550 3560 3570 3580 3590 3600 IVNNPLELTC IASGIPAPKM TWMKDGRPLP QTDQVQTLGG GEVLRISTAQ VEDTGRYTCL 3610 3620 3630 3640 3650 3660 ASSPAGDDDK EYLVRVHVPP NIAGTDEPRD ITVLRNRQVT LECKSDAVPP PVITWLRNGE 3670 3680 3690 3700 3710 3720 RLQATPRVRI LSGGRYLQIN NADLGDTANY TCVASNIAGK TTREFILTVN VPPNIKGGPQ 3730 3740 3750 3760 3770 3780 SLVILLNKST VLECIAEGVP TPRITWRKDG AVLAGNHARY SILENGFLHI QSAHVTDTGR 3790 3800 3810 3820 3830 3840 YLCMATNAAG TDRRRIDLQV HVPPSIAPGP TNMTVIVNVQ TTLACEATGI PKPSINWRKN 3850 3860 3870 3880 3890 3900 GHLLNVDQNQ NSYRLLSSGS LVIISPSVDD TATYECTVTN GAGDDKRTVD LTVQVPPSIA 3910 3920 3930 3940 3950 3960 DEPTDFLVTK HAPAVITCTA SGVPFPSIHW TKNGIRLLPR GDGYRILSSG AIEILATQLN 3970 3980 3990 4000 4010 4020 HAGRYTCVAR NAAGSAHRHV TLHVHEPPVI QPQPSELHVI LNNPILLPCE ATGTPSPFIT 4030 4040 4050 4060 4070 4080 WQKEGINVNT SGRNHAVLPS GGLQISRAVR EDAGTYMCVA QNPAGTALGK IKLNVQVPPV 4090 4100 4110 4120 4130 4140 ISPHLKEYVI AVDKPITLSC EADGLPPPDI TWHKDGRAIV ESIRQRVLSS GSLQIAFVQP 4150 4160 4170 4180 4190 4200 GDAGHYTCMA ANVAGSSSTS TKLTVHVPPR IRSTEGHYTV NENSQAILPC VADGIPTPAI 4210 4220 4230 4240 4250 4260 NWKKDNVLLA NLLGKYTAEP YGELILENVV LEDSGFYTCV ANNAAGEDTH TVSLTVHVLP 4270 4280 4290 4300 4310 4320 TFTELPGDVS LNKGEQLRLS CKATGIPLPK LTWTFNNNII PAHFDSVNGH SELVIERVSK 4330 4340 4350 4360 4370 4380 EDSGTYVCTA ENSVGFVKAI GFVYVKEPPV FKGDYPSNWI EPLGGNAILN CEVKGDPTPT 4390 4400 4410 4420 4430 4440 IQWNRKGVDI EISHRIRQLG NGSLAIYGTV NEDAGDYTCV ATNEAGVVER SMSLTLQSPP 4450 4460 4470 4480 4490 4500 IITLEPVETV INAGGKIILN CQATGEPQPT ITWSRQGHSI SWDDRVNVLS NNSLYIADAQ 4510 4520 4530 4540 4550 4560 KEDTSEFECV ARNLMGSVLV RVPVIVQVHG GFSQWSAWRA CSVTCGKGIQ KRSRLCNQPL 4570 4580 4590 4600 4610 4620 PANGGKPCQG SDLEMRNCQN KPCPVDGSWS EWSLWEECTR SCGRGNQTRT RTCNNPSVQH 4630 4640 4650 4660 4670 4680 GGRPCEGNAV EIIMCNIRPC PVHGAWSAWQ PWGTCSESCG KGTQTRARLC NNPPPAFGGS 4690 4700 4710 4720 4730 4740 YCDGAETQMQ VCNERNCPIH GKWATWASWS ACSVSCGGGA RQRTRGCSDP VPQYGGRKCE 4750 4760 4770 4780 4790 4800 GSDVQSDFCN SDPCPTHGNW SPWSGWGTCS RTCNGGQMRR YRTCDNPPPS NGGRACGGPD 4810 4820 4830 4840 4850 4860 SQIQRCNTDM CPVDGSWGSW HSWSQCSASC GGGEKTRKRL CDHPVPVKGG RPCPGDTTQV 4870 4880 4890 4900 4910 4920 TRCNVQACPG GPQRARGSVI GNINDVEFGI AFLNATITDS PNSDTRIIRA KITNVPRSLG 4930 4940 4950 4960 4970 4980 SAMRKIVSIL NPIYWTTAKE IGEAVNGFTL TNAVFKRETQ VEFATGEILQ MSHIARGLDS 4990 5000 5010 5020 5030 5040 DGSLLLDIVV SGYVLQLQSP AEVTVKDYTE DYIQTGPGQL YAYSTRLFTI DGISIPYTWN 5050 5060 5070 5080 5090 5100 HTVFYDQAQG RMPFLVETLH ASSVESDYNQ IEETLGFKIH ASISKGDRSN QCPSGFTLDS 5110 5120 5130 5140 5150 5160 VGPFCADEDE CAAGNPCSHS CHNAMGTYYC SCPKGLTIAA DGRTCQDIDE CALGRHTCHA 5170 5180 5190 5200 5210 5220 GQDCDNTIGS YRCVVRCGSG FRRTSDGLSC QDINECQESS PCHQRCFNAI GSFHCGCEPG 5230 5240 5250 5260 5270 5280 YQLKGRKCMD VNECRQNVCR PDQHCKNTRG GYKCIDLCPN GMTKAENGTC IDIDECKDGT 5290 5300 5310 5320 5330 5340 HQCRYNQICE NTRGSYRCVC PRGYRSQGVG RPCMDIDECE NTDACQHECK NTFGSYQCIC 5350 5360 5370 5380 5390 5400 PPGYQLTHNG KTCQDIDECL EQNVHCGPNR MCFNMRGSYQ CIDTPCPPNY QRDPVSGFCL 5410 5420 5430 5440 5450 5460 KNCPPNDLEC ALSPYALEYK LVSLPFGIAT NQDLIRLVAY TQDGVMHPRT TFLMVDEEQT 5470 5480 5490 5500 5510 VPFALRDENL KGVVYTTRPL REAETYRMRV RASSYSANGT IEYQTTFIVY IAVSAYPY
	Isoform 3 [UniParc]. Checksum: AE750AA925574A03	FASTA	555	59,747
	10 20 30 40 50 60 MPKNQSFTGG SEVSIMCSAT GYPKPKIAWT VNDMFIVGSH RYRMTSDGTL FIKNAAPKDA 70 80 90 100 110 120 GIYGCLASNS AGTDKQNSTL RYIEAPKLMV VQSELLVALG DITVMECKTS GIPPPQVKWF 130 140 150 160 170 180 KGDLELRPST FLIIDPLLGL LKIQETQDLD AGDYTCVAIN EAGRATGKIT LDVGSPPVFI 190 200 210 220 230 240 QEPADVSMEI GSNVTLPCYV QGYPEPTIKW RRLDNMPIFS RPFSVSSISQ LRTGALFILN 250 260 270 280 290 300 LWASDKGTYI CEAENQFGKI QSETTVTVTG LVAPLIGISP SVANVIEGQQ LTLPCTLLAG 310 320 330 340 350 360 NPIPERRWIK NSAMLLQNPY ITVRSDGSLH IERVQLQDGG EYTCVASNVA GTNNKTTSVV 370 380 390 400 410 420 VHVLPTIQHG QQILSTIEGI PVTLPCKASG NPKPSVIWSK KGELISTSSA KFSAGADGSL 430 440 450 460 470 480 YVVSPGGEES GEYVCTATNT AGYAKRKVQL TVYVRPRVFG DQRGLSQDKP VEISVLAGEE 490 500 510 520 530 540 VTLPCEVKSL PPPIITWAKE TQLISPFSPR HTFLPSGSMK ITETRTSDSG MYLCVATNIA 550 GNVTQAVKLN VHGES

References

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[1]	"Human hemicentin gene." Trent J. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-2418.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 892-2181.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Partial sequence of fibulin-6 with a C-terminal region related to domain II and III of the fibulin family." Kostka G., Timpl R. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2963-5635. Tissue: Melanoma.
[5]	"Analysis of the ARMD1 locus: evidence that a mutation in hemicentin-1 is associated with age-related macular degeneration in a large family." Schultz D.W., Klein M.L., Humpert A.J., Luzier C.W., Persun V., Schain M., Mahan A., Runckel C., Cassera M., Vittal V., Doyle T.M., Martin T.M., Weleber R.G., Francis P.J., Acott T.S. Hum. Mol. Genet. 12:3315-3323(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT ARMD1 ARG-5345, VARIANTS VAL-1624; ILE-2327; THR-2418; GLY-2893; TYR-4084; THR-4720 AND VAL-5087, TISSUE SPECIFICITY, ALTERNATIVE SPLICING (ISOFORM 2).
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF156100 mRNA. Translation: AAK68690.1. AK056336 mRNA. Translation: BAB71154.1. Sequence problems. AK056557 mRNA. Translation: BAB71216.1. Different initiation. BX928748 , AL135796, AL133553, AL133515, AL121996, AL118512, AL391824, AL135797 Genomic DNA. Translation: CAH74051.1. AL121996 , AL135797, AL135796, AL133553, AL133515, AL118512, BX928748, AL391824 Genomic DNA. Translation: CAI17844.1. AL133515 , BX928748, AL391824, AL135797, AL135796, AL133553, AL121996, AL118512 Genomic DNA. Translation: CAI17853.1. AL135796 , AL118512, AL121996, AL133515, AL133553, AL135797, AL391824, BX928748 Genomic DNA. Translation: CAI17854.1. AL133553 , AL118512, AL121996, AL133515, AL135796, AL135797, AL391824, BX928748 Genomic DNA. Translation: CAI17858.1. AL118512 , BX928748, AL391824, AL135797, AL135796, AL133553, AL133515, AL121996 Genomic DNA. Translation: CAI17864.1. AL391824 , AL118512, AL121996, AL133515, AL133553, AL135796, AL135797, BX928748 Genomic DNA. Translation: CAI17865.1. AL135797 , AL118512, AL121996, AL133515, AL133553, AL135796, AL391824, BX928748 Genomic DNA. Translation: CAI17871.1. AJ306906 mRNA. Translation: CAC37630.1.
IPI	IPI00045512. IPI00657877. IPI00871227.
RefSeq	NP_114141.2. NM_031935.2.
UniGene	Hs.58877.
3D structure databases
ProteinModelPortal	Q96RW7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96RW7. 7 interactions.
STRING	9606.ENSP00000271588.
PTM databases
PhosphoSite	Q96RW7.
Polymorphism databases
DMDM	85542049.
Proteomic databases
PaxDb	Q96RW7.
PRIDE	Q96RW7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000271588; ENSP00000271588; ENSG00000143341. ENST00000367492; ENSP00000356462; ENSG00000143341.
GeneID	83872.
KEGG	hsa:83872.
UCSC	uc001grq.1. human. uc001grr.1. human.
Organism-specific databases
CTD	83872.
GeneCards	GC01P185703.
H-InvDB	HIX0001425.
HGNC	HGNC:19194. HMCN1.
HPA	HPA051677.
MIM	603075. phenotype. 608548. gene.
neXtProt	NX_Q96RW7.
Orphanet	279. Age-related macular degeneration.
PharmGKB	PA142671679.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000231553.
HOVERGEN	HBG080319.
InParanoid	Q96RW7.
OMA	RPVQGIP.
OrthoDB	EOG4XGZZ5.
Gene expression databases
ArrayExpress	Q96RW7.
Bgee	Q96RW7.
CleanEx	HS_HMCN1.
Genevestigator	Q96RW7.
GermOnline	ENSG00000143341. Homo sapiens.
Family and domain databases
Gene3D	2.40.155.10. 1 hit. 2.60.40.10. 44 hits.
InterPro	IPR026823. cEGF. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR006605. G2_nidogen/fibulin_G2F. IPR009017. GFP. IPR023413. GFP_like. IPR009030. Growth_fac_rcpt. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR000884. Thrombospondin_1_rpt. IPR002035. VWF_A. [Graphical view]
Pfam	PF12662. cEGF. 1 hit. PF07645. EGF_CA. 6 hits. PF07474. G2F. 1 hit. PF07679. I-set. 43 hits. PF00090. TSP_1. 6 hits. [Graphical view]
SMART	SM00181. EGF. 1 hit. SM00179. EGF_CA. 7 hits. SM00409. IG. 1 hit. SM00408. IGc2. 43 hits. SM00209. TSP1. 6 hits. SM00327. VWA. 1 hit. [Graphical view]
SUPFAM	SSF54511. GFP_like. 1 hit. SSF57184. Grow_fac_recept. 1 hit. SSF82895. TSP1. 6 hits.
PROSITE	PS00010. ASX_HYDROXYL. 5 hits. PS00022. EGF_1. False negative. PS01186. EGF_2. 3 hits. PS50026. EGF_3. 5 hits. PS01187. EGF_CA. 8 hits. PS50835. IG_LIKE. 44 hits. PS50993. NIDOGEN_G2. 1 hit. PS50092. TSP1. 6 hits. PS50234. VWFA. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	83872.
NextBio	72899.
SOURCE	Search...

Entry information

Entry name

HMCN1_HUMAN

Accession

Primary (citable) accession number: Q96RW7
Secondary accession number(s): A6NGE3 , Q5TYR7, Q96DN3, Q96DN8, Q96SC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	January 10, 2006
Last modified:	May 1, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.