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Protein

Pecanex-like protein 1

Gene

PCNX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pecanex-like protein 1
Alternative name(s):
Pecanex homolog protein 1Imported
Gene namesi
Name:PCNX1Imported
Synonyms:KIAA0805, KIAA0995, PCNX, PCNXL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19740. PCNX1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 50HelicalSequence analysisAdd BLAST23
Transmembranei57 – 74HelicalSequence analysisAdd BLAST18
Transmembranei1003 – 1025HelicalSequence analysisAdd BLAST23
Transmembranei1032 – 1049HelicalSequence analysisAdd BLAST18
Transmembranei1067 – 1089HelicalSequence analysisAdd BLAST23
Transmembranei1110 – 1132HelicalSequence analysisAdd BLAST23
Transmembranei1160 – 1182HelicalSequence analysisAdd BLAST23
Transmembranei1194 – 1213HelicalSequence analysisAdd BLAST20
Transmembranei1266 – 1288HelicalSequence analysisAdd BLAST23
Transmembranei1295 – 1312HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi22990.
OpenTargetsiENSG00000100731.
PharmGKBiPA134905848.

Polymorphism and mutation databases

BioMutaiPCNX.
DMDMi116242705.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002157931 – 2341Pecanex-like protein 1Add BLAST2341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Glycosylationi215N-linked (GlcNAc...)Sequence analysis1
Glycosylationi348N-linked (GlcNAc...)Sequence analysis1
Glycosylationi394N-linked (GlcNAc...)Sequence analysis1
Glycosylationi702N-linked (GlcNAc...)Sequence analysis1
Glycosylationi852N-linked (GlcNAc...)Sequence analysis1
Glycosylationi863N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1091N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1155N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1579N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1720N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1982N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2062N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2072N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2234N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2260N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96RV3.
MaxQBiQ96RV3.
PaxDbiQ96RV3.
PeptideAtlasiQ96RV3.
PRIDEiQ96RV3.

PTM databases

iPTMnetiQ96RV3.
PhosphoSitePlusiQ96RV3.

Expressioni

Gene expression databases

BgeeiENSG00000100731.
CleanExiHS_PCNX.
ExpressionAtlasiQ96RV3. baseline and differential.
GenevisibleiQ96RV3. HS.

Organism-specific databases

HPAiHPA053532.

Interactioni

Protein-protein interaction databases

BioGridi116638. 1 interactor.
IntActiQ96RV3. 2 interactors.
STRINGi9606.ENSP00000304192.

Structurei

3D structure databases

ProteinModelPortaliQ96RV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi245 – 250Poly-His6
Compositional biasi602 – 635Ser-richAdd BLAST34
Compositional biasi2103 – 2199Ser-richAdd BLAST97

Sequence similaritiesi

Belongs to the pecanex family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3604. Eukaryota.
ENOG410XPRI. LUCA.
GeneTreeiENSGT00390000013164.
HOGENOMiHOG000007773.
HOVERGENiHBG045627.
InParanoidiQ96RV3.
OMAiVNYRLHR.
OrthoDBiEOG090300PK.
PhylomeDBiQ96RV3.
TreeFamiTF313570.

Family and domain databases

InterProiView protein in InterPro
IPR007735. Pecanex.
PfamiView protein in Pfam
PF05041. Pecanex_C. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96RV3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSQTLQILR QGVWAALSGG WYYDPHQATF VNALHLYLWL FLLGLPFTLY
60 70 80 90 100
MALPSTMIIV AVYCPVIAAV FIVLKMVNYR LHRALDAGEV VDRTANEFTD
110 120 130 140 150
QRTKAEQGNC STRRKDSNGP SDPGGGIEMS EFIREATPPV GCSSRNSYAG
160 170 180 190 200
LDPSNQIGSG SSRLGTAATI KGDTDTAKTS DDISLSLGQS SSLCKEGSEE
210 220 230 240 250
QDLAADRKLF RLVSNDSFIS IQPSLSSCGQ DLPRDFSDKV NLPSHNHHHH
260 270 280 290 300
VDQSLSSACD TEVASLVPLH SHSYRKDHRP RGVPRTSSSA VAFPDTSLND
310 320 330 340 350
FPLYQQRRGL DPVSELESSK PLSGSKESLV ENSGLSGEFQ LAGDLKINTS
360 370 380 390 400
QPPTKSGKSK PLKAEKSMDS LRSLSTRSSG STESYCSGTD RDTNSTVSSY
410 420 430 440 450
KSEQTSSTHI ESILSEHEES PKAGTKSGRK KECCAGPEEK NSCASDKRTS
460 470 480 490 500
SEKIAMEAST NSGVHEAKDP TPSDEMHNQR GLSTSASEEA NKNPHANEFT
510 520 530 540 550
SQGDRPPGNT AENKEEKSDK SAVSVDSKVR KDVGGKQKEG DVRPKSSSVI
560 570 580 590 600
HRTASAHKSG RRRTGKKRAS SFDSSRHRDY VCFRGVSGTK PHSAIFCHDE
610 620 630 640 650
DSSDQSDLSR ASSVQSAHQF SSDSSSSTTS HSCQSPEGRY SALKTKHTHK
660 670 680 690 700
ERGTDSEHTH KAHLVPEGTS KKRATRRTSS TNSAKTRARV LSLDSGTVAC
710 720 730 740 750
LNDSNRLMAP ESIKPLTTSK SDLEAKEGEV LDELSLLGRA SQLETVTRSR
760 770 780 790 800
NSLPNQVAFP EGEEQDAVSG AAQASEEAVS FRRERSTFRR QAVRRRHNAG
810 820 830 840 850
SNPTPPTLLI GSPLSLQDGQ QGQQSTAQVK VQSRPPSQAA VLSASASLLV
860 870 880 890 900
RNGSVHLEAS HDNASAVGGS SLHDELGKFS STLYETGGCD MSLVNFEPAA
910 920 930 940 950
RRASNICDTD SHVSSSTSVR FYPHDVLSLP QIRLNRLLTI DTDLLEQQDI
960 970 980 990 1000
DLSPDLAATY GPTEEAAQKV KHYYRFWILP QLWIGINFDR LTLLALFDRN
1010 1020 1030 1040 1050
REILENVLAV ILAILVAFLG SILLIQGFFR DIWVFQFCLV IASCQYSLLK
1060 1070 1080 1090 1100
SVQPDSSSPR HGHNRIIAYS RPVYFCICCG LIWLLDYGSR NLTATKFKLY
1110 1120 1130 1140 1150
GITFTNPLVF ISARDLVIVF TLCFPIVFFI GLLPQVNTFV MYLCEQLDIH
1160 1170 1180 1190 1200
IFGGNATTSL LAALYSFICS IVAVALLYGL CYGALKDSWD GQHIPVLFSI
1210 1220 1230 1240 1250
FCGLLVAVSY HLSRQSSDPS VLFSLVQSKI FPKTEEKNPE DPLSEVKDPL
1260 1270 1280 1290 1300
PEKLRNSVSE RLQSDLVVCI VIGVLYFAIH VSTVFTVLQP ALKYVLYTLV
1310 1320 1330 1340 1350
GFVGFVTHYV LPQVRKQLPW HCFSHPLLKT LEYNQYEVRN AATMMWFEKL
1360 1370 1380 1390 1400
HVWLLFVEKN IIYPLIVLNE LSSSAETIAS PKKLNTELGA LMITVAGLKL
1410 1420 1430 1440 1450
LRSSFSSPTY QYVTVIFTVL FFKFDYEAFS ETMLLDLFFM SILFNKLWEL
1460 1470 1480 1490 1500
LYKLQFVYTY IAPWQITWGS AFHAFAQPFA VPHSAMLFIQ AAVSAFFSTP
1510 1520 1530 1540 1550
LNPFLGSAIF ITSYVRPVKF WERDYNTKRV DHSNTRLASQ LDRNPGSDDN
1560 1570 1580 1590 1600
NLNSIFYEHL TRSLQHSLCG DLLLGRWGNY STGDCFILAS DYLNALVHLI
1610 1620 1630 1640 1650
EIGNGLVTFQ LRGLEFRGTY CQQREVEAIT EGVEEDEGFC CCEPGHIPHM
1660 1670 1680 1690 1700
LSFNAAFSQR WLAWEVIVTK YILEGYSITD NSAASMLQVF DLRKVLTTYY
1710 1720 1730 1740 1750
VKGIIYYVTT SSKLEEWLAN ETMQEGLRLC ADRNYVDVDP TFNPNIDEDY
1760 1770 1780 1790 1800
DHRLAGISRE SFCVIYLNWI EYCSSRRAKP VDVDKDSSLV TLCYGLCVLG
1810 1820 1830 1840 1850
RRALGTASHH MSSNLESFLY GLHALFKGDF RISSIRDEWI FADMELLRKV
1860 1870 1880 1890 1900
VVPGIRMSIK LHQDHFTSPD EYDDPTVLYE AIVSHEKNLV IAHEGDPAWR
1910 1920 1930 1940 1950
SAVLANSPSL LALRHVMDDG TNEYKIIMLN RRYLSFRVIK VNKECVRGLW
1960 1970 1980 1990 2000
AGQQQELVFL RNRNPERGSI QNAKQALRNM INSSCDQPIG YPIFVSPLTT
2010 2020 2030 2040 2050
SYSDSHEQLK DILGGPISLG NIRNFIVSTW HRLRKGCGAG CNSGGNIEDS
2060 2070 2080 2090 2100
DTGGGTSCTG NNATTANNPH SNVTQGSIGN PGQGSGTGLH PPVTSYPPTL
2110 2120 2130 2140 2150
GTSHSSHSVQ SGLVRQSPAR ASVASQSSYC YSSRHSSLRM STTGFVPCRR
2160 2170 2180 2190 2200
SSTSQISLRN LPSSIQSRLS MVNQMEPSGQ SGLACVQHGL PSSSSSSQSI
2210 2220 2230 2240 2250
PACKHHTLVG FLATEGGQSS ATDAQPGNTL SPANNSHSRK AEVIYRVQIV
2260 2270 2280 2290 2300
DPSQILEGIN LSKRKELQWP DEGIRLKAGR NSWKDWSPQE GMEGHVIHRW
2310 2320 2330 2340
VPCSRDPGTR SHIDKAVLLV QIDDKYVTVI ETGVLELGAE V
Length:2,341
Mass (Da):258,676
Last modified:October 17, 2006 - v2
Checksum:i3C38BD853B2F59D1
GO
Isoform 2 (identifier: Q96RV3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     851-866: RNGSVHLEASHDNASA → SSLLRCMRLVAVICHL
     867-2341: Missing.

Note: No experimental confirmation available.
Show »
Length:866
Mass (Da):93,579
Checksum:i5F52C44695B17D01
GO
Isoform 3 (identifier: Q96RV3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1546-1617: Missing.

Note: No experimental confirmation available.
Show »
Length:2,269
Mass (Da):250,606
Checksum:iAFB883ABABFAB0F5
GO
Isoform 4 (identifier: Q96RV3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     771-876: Missing.
     927-931: Missing.

Note: No experimental confirmation available.
Show »
Length:2,230
Mass (Da):246,976
Checksum:i8947409A0692F3D9
GO

Sequence cautioni

The sequence BAA76839 differs from that shown. Reason: Frameshift at position 41.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2239R → K in AAK82958 (Ref. 1) Curated1
Sequence conflicti2239R → K in BAA34525 (PubMed:9872452).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050478594A → T. Corresponds to variant dbSNP:rs34222509Ensembl.1
Natural variantiVAR_028305809L → I. Corresponds to variant dbSNP:rs11625687Ensembl.1
Natural variantiVAR_028306814L → I. Corresponds to variant dbSNP:rs11625690Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054500771 – 876Missing in isoform 4. 1 PublicationAdd BLAST106
Alternative sequenceiVSP_008401851 – 866RNGSV…DNASA → SSLLRCMRLVAVICHL in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_008402867 – 2341Missing in isoform 2. 1 PublicationAdd BLAST1475
Alternative sequenceiVSP_054501927 – 931Missing in isoform 4. 1 Publication5
Alternative sequenceiVSP_0084031546 – 1617Missing in isoform 3. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233450 mRNA. Translation: AAK82958.1.
AB023212 mRNA. Translation: BAA76839.1. Frameshift.
AC004825 Genomic DNA. No translation available.
AL445903 Genomic DNA. No translation available.
AC005230 Genomic DNA. No translation available.
AC004817 Genomic DNA. No translation available.
BC017076 mRNA. Translation: AAH17076.2.
BC140784 mRNA. Translation: AAI40785.1.
AB018348 mRNA. Translation: BAA34525.1.
CCDSiCCDS76695.1. [Q96RV3-4]
CCDS9806.1. [Q96RV3-1]
RefSeqiNP_001295089.1. NM_001308160.1. [Q96RV3-4]
NP_055797.2. NM_014982.2. [Q96RV3-1]
UniGeneiHs.446559.

Genome annotation databases

EnsembliENST00000304743; ENSP00000304192; ENSG00000100731. [Q96RV3-1]
ENST00000439984; ENSP00000396617; ENSG00000100731. [Q96RV3-4]
GeneIDi22990.
KEGGihsa:22990.
UCSCiuc001xmo.2. human. [Q96RV3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233450 mRNA. Translation: AAK82958.1.
AB023212 mRNA. Translation: BAA76839.1. Frameshift.
AC004825 Genomic DNA. No translation available.
AL445903 Genomic DNA. No translation available.
AC005230 Genomic DNA. No translation available.
AC004817 Genomic DNA. No translation available.
BC017076 mRNA. Translation: AAH17076.2.
BC140784 mRNA. Translation: AAI40785.1.
AB018348 mRNA. Translation: BAA34525.1.
CCDSiCCDS76695.1. [Q96RV3-4]
CCDS9806.1. [Q96RV3-1]
RefSeqiNP_001295089.1. NM_001308160.1. [Q96RV3-4]
NP_055797.2. NM_014982.2. [Q96RV3-1]
UniGeneiHs.446559.

3D structure databases

ProteinModelPortaliQ96RV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116638. 1 interactor.
IntActiQ96RV3. 2 interactors.
STRINGi9606.ENSP00000304192.

PTM databases

iPTMnetiQ96RV3.
PhosphoSitePlusiQ96RV3.

Polymorphism and mutation databases

BioMutaiPCNX.
DMDMi116242705.

Proteomic databases

EPDiQ96RV3.
MaxQBiQ96RV3.
PaxDbiQ96RV3.
PeptideAtlasiQ96RV3.
PRIDEiQ96RV3.

Protocols and materials databases

DNASUi22990.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304743; ENSP00000304192; ENSG00000100731. [Q96RV3-1]
ENST00000439984; ENSP00000396617; ENSG00000100731. [Q96RV3-4]
GeneIDi22990.
KEGGihsa:22990.
UCSCiuc001xmo.2. human. [Q96RV3-1]

Organism-specific databases

CTDi22990.
DisGeNETi22990.
GeneCardsiPCNX1.
H-InvDBHIX0011780.
HGNCiHGNC:19740. PCNX1.
HPAiHPA053532.
neXtProtiNX_Q96RV3.
OpenTargetsiENSG00000100731.
PharmGKBiPA134905848.
HUGEiSearch...
Search...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3604. Eukaryota.
ENOG410XPRI. LUCA.
GeneTreeiENSGT00390000013164.
HOGENOMiHOG000007773.
HOVERGENiHBG045627.
InParanoidiQ96RV3.
OMAiVNYRLHR.
OrthoDBiEOG090300PK.
PhylomeDBiQ96RV3.
TreeFamiTF313570.

Miscellaneous databases

ChiTaRSiPCNX. human.
GeneWikiiPCNX.
GenomeRNAii22990.
PROiQ96RV3.

Gene expression databases

BgeeiENSG00000100731.
CleanExiHS_PCNX.
ExpressionAtlasiQ96RV3. baseline and differential.
GenevisibleiQ96RV3. HS.

Family and domain databases

InterProiView protein in InterPro
IPR007735. Pecanex.
PfamiView protein in Pfam
PF05041. Pecanex_C. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPCX1_HUMAN
AccessioniPrimary (citable) accession number: Q96RV3
Secondary accession number(s): B2RTR6
, O94897, Q96AI7, Q9Y2J9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 17, 2006
Last modified: February 15, 2017
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.