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Q96RV3 (PCX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pecanex-like protein 1
Alternative name(s):
Pecanex homolog
Gene names
Name:PCNX
Synonyms:KIAA0805, KIAA0995, PCNXL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2341 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the pecanex family.

Sequence caution

The sequence BAA76839.1 differs from that shown. Reason: Frameshift at position 41.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96RV3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96RV3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     851-866: RNGSVHLEASHDNASA → SSLLRCMRLVAVICHL
     867-2341: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q96RV3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1546-1617: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 23412341Pecanex-like protein 1
PRO_0000215793

Regions

Transmembrane28 – 5023Helical; Potential
Transmembrane57 – 7418Helical; Potential
Transmembrane1003 – 102523Helical; Potential
Transmembrane1032 – 104918Helical; Potential
Transmembrane1067 – 108923Helical; Potential
Transmembrane1110 – 113223Helical; Potential
Transmembrane1160 – 118223Helical; Potential
Transmembrane1194 – 121320Helical; Potential
Transmembrane1266 – 128823Helical; Potential
Transmembrane1295 – 131218Helical; Potential
Compositional bias245 – 2506Poly-His
Compositional bias602 – 63534Ser-rich
Compositional bias2103 – 219997Ser-rich

Amino acid modifications

Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation2151N-linked (GlcNAc...) Potential
Glycosylation3481N-linked (GlcNAc...) Potential
Glycosylation3941N-linked (GlcNAc...) Potential
Glycosylation7021N-linked (GlcNAc...) Potential
Glycosylation8521N-linked (GlcNAc...) Potential
Glycosylation8631N-linked (GlcNAc...) Potential
Glycosylation10911N-linked (GlcNAc...) Potential
Glycosylation11551N-linked (GlcNAc...) Potential
Glycosylation15791N-linked (GlcNAc...) Potential
Glycosylation17201N-linked (GlcNAc...) Potential
Glycosylation19821N-linked (GlcNAc...) Potential
Glycosylation20621N-linked (GlcNAc...) Potential
Glycosylation20721N-linked (GlcNAc...) Potential
Glycosylation22341N-linked (GlcNAc...) Potential
Glycosylation22601N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence851 – 86616RNGSV…DNASA → SSLLRCMRLVAVICHL in isoform 2.
VSP_008401
Alternative sequence867 – 23411475Missing in isoform 2.
VSP_008402
Alternative sequence1546 – 161772Missing in isoform 3.
VSP_008403
Natural variant5941A → T.
Corresponds to variant rs34222509 [ dbSNP | Ensembl ].
VAR_050478
Natural variant8091L → I.
Corresponds to variant rs11625687 [ dbSNP | Ensembl ].
VAR_028305
Natural variant8141L → I.
Corresponds to variant rs11625690 [ dbSNP | Ensembl ].
VAR_028306

Experimental info

Sequence conflict22391R → K in AAK82958. Ref.1
Sequence conflict22391R → K in BAA34525. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 3C38BD853B2F59D1

FASTA2,341258,676
        10         20         30         40         50         60 
MGSQTLQILR QGVWAALSGG WYYDPHQATF VNALHLYLWL FLLGLPFTLY MALPSTMIIV 

        70         80         90        100        110        120 
AVYCPVIAAV FIVLKMVNYR LHRALDAGEV VDRTANEFTD QRTKAEQGNC STRRKDSNGP 

       130        140        150        160        170        180 
SDPGGGIEMS EFIREATPPV GCSSRNSYAG LDPSNQIGSG SSRLGTAATI KGDTDTAKTS 

       190        200        210        220        230        240 
DDISLSLGQS SSLCKEGSEE QDLAADRKLF RLVSNDSFIS IQPSLSSCGQ DLPRDFSDKV 

       250        260        270        280        290        300 
NLPSHNHHHH VDQSLSSACD TEVASLVPLH SHSYRKDHRP RGVPRTSSSA VAFPDTSLND 

       310        320        330        340        350        360 
FPLYQQRRGL DPVSELESSK PLSGSKESLV ENSGLSGEFQ LAGDLKINTS QPPTKSGKSK 

       370        380        390        400        410        420 
PLKAEKSMDS LRSLSTRSSG STESYCSGTD RDTNSTVSSY KSEQTSSTHI ESILSEHEES 

       430        440        450        460        470        480 
PKAGTKSGRK KECCAGPEEK NSCASDKRTS SEKIAMEAST NSGVHEAKDP TPSDEMHNQR 

       490        500        510        520        530        540 
GLSTSASEEA NKNPHANEFT SQGDRPPGNT AENKEEKSDK SAVSVDSKVR KDVGGKQKEG 

       550        560        570        580        590        600 
DVRPKSSSVI HRTASAHKSG RRRTGKKRAS SFDSSRHRDY VCFRGVSGTK PHSAIFCHDE 

       610        620        630        640        650        660 
DSSDQSDLSR ASSVQSAHQF SSDSSSSTTS HSCQSPEGRY SALKTKHTHK ERGTDSEHTH 

       670        680        690        700        710        720 
KAHLVPEGTS KKRATRRTSS TNSAKTRARV LSLDSGTVAC LNDSNRLMAP ESIKPLTTSK 

       730        740        750        760        770        780 
SDLEAKEGEV LDELSLLGRA SQLETVTRSR NSLPNQVAFP EGEEQDAVSG AAQASEEAVS 

       790        800        810        820        830        840 
FRRERSTFRR QAVRRRHNAG SNPTPPTLLI GSPLSLQDGQ QGQQSTAQVK VQSRPPSQAA 

       850        860        870        880        890        900 
VLSASASLLV RNGSVHLEAS HDNASAVGGS SLHDELGKFS STLYETGGCD MSLVNFEPAA 

       910        920        930        940        950        960 
RRASNICDTD SHVSSSTSVR FYPHDVLSLP QIRLNRLLTI DTDLLEQQDI DLSPDLAATY 

       970        980        990       1000       1010       1020 
GPTEEAAQKV KHYYRFWILP QLWIGINFDR LTLLALFDRN REILENVLAV ILAILVAFLG 

      1030       1040       1050       1060       1070       1080 
SILLIQGFFR DIWVFQFCLV IASCQYSLLK SVQPDSSSPR HGHNRIIAYS RPVYFCICCG 

      1090       1100       1110       1120       1130       1140 
LIWLLDYGSR NLTATKFKLY GITFTNPLVF ISARDLVIVF TLCFPIVFFI GLLPQVNTFV 

      1150       1160       1170       1180       1190       1200 
MYLCEQLDIH IFGGNATTSL LAALYSFICS IVAVALLYGL CYGALKDSWD GQHIPVLFSI 

      1210       1220       1230       1240       1250       1260 
FCGLLVAVSY HLSRQSSDPS VLFSLVQSKI FPKTEEKNPE DPLSEVKDPL PEKLRNSVSE 

      1270       1280       1290       1300       1310       1320 
RLQSDLVVCI VIGVLYFAIH VSTVFTVLQP ALKYVLYTLV GFVGFVTHYV LPQVRKQLPW 

      1330       1340       1350       1360       1370       1380 
HCFSHPLLKT LEYNQYEVRN AATMMWFEKL HVWLLFVEKN IIYPLIVLNE LSSSAETIAS 

      1390       1400       1410       1420       1430       1440 
PKKLNTELGA LMITVAGLKL LRSSFSSPTY QYVTVIFTVL FFKFDYEAFS ETMLLDLFFM 

      1450       1460       1470       1480       1490       1500 
SILFNKLWEL LYKLQFVYTY IAPWQITWGS AFHAFAQPFA VPHSAMLFIQ AAVSAFFSTP 

      1510       1520       1530       1540       1550       1560 
LNPFLGSAIF ITSYVRPVKF WERDYNTKRV DHSNTRLASQ LDRNPGSDDN NLNSIFYEHL 

      1570       1580       1590       1600       1610       1620 
TRSLQHSLCG DLLLGRWGNY STGDCFILAS DYLNALVHLI EIGNGLVTFQ LRGLEFRGTY 

      1630       1640       1650       1660       1670       1680 
CQQREVEAIT EGVEEDEGFC CCEPGHIPHM LSFNAAFSQR WLAWEVIVTK YILEGYSITD 

      1690       1700       1710       1720       1730       1740 
NSAASMLQVF DLRKVLTTYY VKGIIYYVTT SSKLEEWLAN ETMQEGLRLC ADRNYVDVDP 

      1750       1760       1770       1780       1790       1800 
TFNPNIDEDY DHRLAGISRE SFCVIYLNWI EYCSSRRAKP VDVDKDSSLV TLCYGLCVLG 

      1810       1820       1830       1840       1850       1860 
RRALGTASHH MSSNLESFLY GLHALFKGDF RISSIRDEWI FADMELLRKV VVPGIRMSIK 

      1870       1880       1890       1900       1910       1920 
LHQDHFTSPD EYDDPTVLYE AIVSHEKNLV IAHEGDPAWR SAVLANSPSL LALRHVMDDG 

      1930       1940       1950       1960       1970       1980 
TNEYKIIMLN RRYLSFRVIK VNKECVRGLW AGQQQELVFL RNRNPERGSI QNAKQALRNM 

      1990       2000       2010       2020       2030       2040 
INSSCDQPIG YPIFVSPLTT SYSDSHEQLK DILGGPISLG NIRNFIVSTW HRLRKGCGAG 

      2050       2060       2070       2080       2090       2100 
CNSGGNIEDS DTGGGTSCTG NNATTANNPH SNVTQGSIGN PGQGSGTGLH PPVTSYPPTL 

      2110       2120       2130       2140       2150       2160 
GTSHSSHSVQ SGLVRQSPAR ASVASQSSYC YSSRHSSLRM STTGFVPCRR SSTSQISLRN 

      2170       2180       2190       2200       2210       2220 
LPSSIQSRLS MVNQMEPSGQ SGLACVQHGL PSSSSSSQSI PACKHHTLVG FLATEGGQSS 

      2230       2240       2250       2260       2270       2280 
ATDAQPGNTL SPANNSHSRK AEVIYRVQIV DPSQILEGIN LSKRKELQWP DEGIRLKAGR 

      2290       2300       2310       2320       2330       2340 
NSWKDWSPQE GMEGHVIHRW VPCSRDPGTR SHIDKAVLLV QIDDKYVTVI ETGVLELGAE 


V 

« Hide

Isoform 2 [UniParc].

Checksum: 5F52C44695B17D01
Show »

FASTA86693,579
Isoform 3 [UniParc].

Checksum: AFB883ABABFAB0F5
Show »

FASTA2,269250,606

References

« Hide 'large scale' references
[1]"Cloning, mapping and characterization of PCNXL1, a member of a new family of vertebrate homologs of the Drosophila neurogenic gene pecanex."
Roux A.-F., Gasca S., Bagheri-Fam S., Saridaki A., Sanoudou D., Ferraz C., Demaille J., Ferguson-Smith M., Scherer G.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 943-2341 (ISOFORM 3).
Tissue: Brain.
[5]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1803-2341.
Tissue: Colon.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF233450 mRNA. Translation: AAK82958.1.
AB023212 mRNA. Translation: BAA76839.1. Frameshift.
AC004825 Genomic DNA. No translation available.
AL445903 Genomic DNA. No translation available.
AC005230 Genomic DNA. No translation available.
AC004817 Genomic DNA. No translation available.
AB018348 mRNA. Translation: BAA34525.1.
BC017076 mRNA. Translation: AAH17076.2.
RefSeqNP_055797.2. NM_014982.2.
UniGeneHs.446559.

3D structure databases

ProteinModelPortalQ96RV3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116638. 2 interactions.
IntActQ96RV3. 2 interactions.

PTM databases

PhosphoSiteQ96RV3.

Polymorphism databases

DMDM116242705.

Proteomic databases

PaxDbQ96RV3.
PRIDEQ96RV3.

Protocols and materials databases

DNASU22990.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000238570; ENSP00000238570; ENSG00000100731. [Q96RV3-3]
ENST00000304743; ENSP00000304192; ENSG00000100731. [Q96RV3-1]
GeneID22990.
KEGGhsa:22990.
UCSCuc001xmn.4. human. [Q96RV3-2]
uc001xmo.2. human. [Q96RV3-1]

Organism-specific databases

CTD22990.
GeneCardsGC14P071374.
H-InvDBHIX0011780.
HGNCHGNC:19740. PCNX.
HPAHPA053532.
neXtProtNX_Q96RV3.
PharmGKBPA134905848.
HUGESearch...
Search...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG297934.
HOGENOMHOG000007773.
HOVERGENHBG045627.
InParanoidQ96RV3.
OMAPRGVPRT.
OrthoDBEOG72VH54.
PhylomeDBQ96RV3.
TreeFamTF313570.

Gene expression databases

ArrayExpressQ96RV3.
BgeeQ96RV3.
CleanExHS_PCNX.
GenevestigatorQ96RV3.

Family and domain databases

InterProIPR007735. Pecanex.
[Graphical view]
PfamPF05041. Pecanex_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPCNX. human.
GeneWikiPCNX.
GenomeRNAi22990.
NextBio43843.
PROQ96RV3.

Entry information

Entry namePCX1_HUMAN
AccessionPrimary (citable) accession number: Q96RV3
Secondary accession number(s): O94897, Q96AI7, Q9Y2J9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 17, 2006
Last modified: March 19, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM