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Q96RV3

- PCX1_HUMAN

UniProt

Q96RV3 - PCX1_HUMAN

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Protein

Pecanex-like protein 1

Gene
PCNX, KIAA0805, KIAA0995, PCNXL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pecanex-like protein 1
Alternative name(s):
Pecanex homolog
Gene namesi
Name:PCNX
Synonyms:KIAA0805, KIAA0995, PCNXL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:19740. PCNX.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 5023Helical; Reviewed predictionAdd
BLAST
Transmembranei57 – 7418Helical; Reviewed predictionAdd
BLAST
Transmembranei1003 – 102523Helical; Reviewed predictionAdd
BLAST
Transmembranei1032 – 104918Helical; Reviewed predictionAdd
BLAST
Transmembranei1067 – 108923Helical; Reviewed predictionAdd
BLAST
Transmembranei1110 – 113223Helical; Reviewed predictionAdd
BLAST
Transmembranei1160 – 118223Helical; Reviewed predictionAdd
BLAST
Transmembranei1194 – 121320Helical; Reviewed predictionAdd
BLAST
Transmembranei1266 – 128823Helical; Reviewed predictionAdd
BLAST
Transmembranei1295 – 131218Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134905848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23412341Pecanex-like protein 1PRO_0000215793Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi215 – 2151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi348 – 3481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi394 – 3941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi702 – 7021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi852 – 8521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi863 – 8631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1091 – 10911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1155 – 11551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1579 – 15791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1720 – 17201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1982 – 19821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2062 – 20621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2072 – 20721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2234 – 22341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2260 – 22601N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96RV3.
PaxDbiQ96RV3.
PRIDEiQ96RV3.

PTM databases

PhosphoSiteiQ96RV3.

Expressioni

Gene expression databases

ArrayExpressiQ96RV3.
BgeeiQ96RV3.
CleanExiHS_PCNX.
GenevestigatoriQ96RV3.

Organism-specific databases

HPAiHPA053532.

Interactioni

Protein-protein interaction databases

BioGridi116638. 2 interactions.
IntActiQ96RV3. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ96RV3.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi245 – 2506Poly-His
Compositional biasi602 – 63534Ser-richAdd
BLAST
Compositional biasi2103 – 219997Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the pecanex family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG297934.
HOGENOMiHOG000007773.
HOVERGENiHBG045627.
InParanoidiQ96RV3.
OMAiNYRLHRA.
OrthoDBiEOG72VH54.
PhylomeDBiQ96RV3.
TreeFamiTF313570.

Family and domain databases

InterProiIPR007735. Pecanex.
[Graphical view]
PfamiPF05041. Pecanex_C. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96RV3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGSQTLQILR QGVWAALSGG WYYDPHQATF VNALHLYLWL FLLGLPFTLY     50
MALPSTMIIV AVYCPVIAAV FIVLKMVNYR LHRALDAGEV VDRTANEFTD 100
QRTKAEQGNC STRRKDSNGP SDPGGGIEMS EFIREATPPV GCSSRNSYAG 150
LDPSNQIGSG SSRLGTAATI KGDTDTAKTS DDISLSLGQS SSLCKEGSEE 200
QDLAADRKLF RLVSNDSFIS IQPSLSSCGQ DLPRDFSDKV NLPSHNHHHH 250
VDQSLSSACD TEVASLVPLH SHSYRKDHRP RGVPRTSSSA VAFPDTSLND 300
FPLYQQRRGL DPVSELESSK PLSGSKESLV ENSGLSGEFQ LAGDLKINTS 350
QPPTKSGKSK PLKAEKSMDS LRSLSTRSSG STESYCSGTD RDTNSTVSSY 400
KSEQTSSTHI ESILSEHEES PKAGTKSGRK KECCAGPEEK NSCASDKRTS 450
SEKIAMEAST NSGVHEAKDP TPSDEMHNQR GLSTSASEEA NKNPHANEFT 500
SQGDRPPGNT AENKEEKSDK SAVSVDSKVR KDVGGKQKEG DVRPKSSSVI 550
HRTASAHKSG RRRTGKKRAS SFDSSRHRDY VCFRGVSGTK PHSAIFCHDE 600
DSSDQSDLSR ASSVQSAHQF SSDSSSSTTS HSCQSPEGRY SALKTKHTHK 650
ERGTDSEHTH KAHLVPEGTS KKRATRRTSS TNSAKTRARV LSLDSGTVAC 700
LNDSNRLMAP ESIKPLTTSK SDLEAKEGEV LDELSLLGRA SQLETVTRSR 750
NSLPNQVAFP EGEEQDAVSG AAQASEEAVS FRRERSTFRR QAVRRRHNAG 800
SNPTPPTLLI GSPLSLQDGQ QGQQSTAQVK VQSRPPSQAA VLSASASLLV 850
RNGSVHLEAS HDNASAVGGS SLHDELGKFS STLYETGGCD MSLVNFEPAA 900
RRASNICDTD SHVSSSTSVR FYPHDVLSLP QIRLNRLLTI DTDLLEQQDI 950
DLSPDLAATY GPTEEAAQKV KHYYRFWILP QLWIGINFDR LTLLALFDRN 1000
REILENVLAV ILAILVAFLG SILLIQGFFR DIWVFQFCLV IASCQYSLLK 1050
SVQPDSSSPR HGHNRIIAYS RPVYFCICCG LIWLLDYGSR NLTATKFKLY 1100
GITFTNPLVF ISARDLVIVF TLCFPIVFFI GLLPQVNTFV MYLCEQLDIH 1150
IFGGNATTSL LAALYSFICS IVAVALLYGL CYGALKDSWD GQHIPVLFSI 1200
FCGLLVAVSY HLSRQSSDPS VLFSLVQSKI FPKTEEKNPE DPLSEVKDPL 1250
PEKLRNSVSE RLQSDLVVCI VIGVLYFAIH VSTVFTVLQP ALKYVLYTLV 1300
GFVGFVTHYV LPQVRKQLPW HCFSHPLLKT LEYNQYEVRN AATMMWFEKL 1350
HVWLLFVEKN IIYPLIVLNE LSSSAETIAS PKKLNTELGA LMITVAGLKL 1400
LRSSFSSPTY QYVTVIFTVL FFKFDYEAFS ETMLLDLFFM SILFNKLWEL 1450
LYKLQFVYTY IAPWQITWGS AFHAFAQPFA VPHSAMLFIQ AAVSAFFSTP 1500
LNPFLGSAIF ITSYVRPVKF WERDYNTKRV DHSNTRLASQ LDRNPGSDDN 1550
NLNSIFYEHL TRSLQHSLCG DLLLGRWGNY STGDCFILAS DYLNALVHLI 1600
EIGNGLVTFQ LRGLEFRGTY CQQREVEAIT EGVEEDEGFC CCEPGHIPHM 1650
LSFNAAFSQR WLAWEVIVTK YILEGYSITD NSAASMLQVF DLRKVLTTYY 1700
VKGIIYYVTT SSKLEEWLAN ETMQEGLRLC ADRNYVDVDP TFNPNIDEDY 1750
DHRLAGISRE SFCVIYLNWI EYCSSRRAKP VDVDKDSSLV TLCYGLCVLG 1800
RRALGTASHH MSSNLESFLY GLHALFKGDF RISSIRDEWI FADMELLRKV 1850
VVPGIRMSIK LHQDHFTSPD EYDDPTVLYE AIVSHEKNLV IAHEGDPAWR 1900
SAVLANSPSL LALRHVMDDG TNEYKIIMLN RRYLSFRVIK VNKECVRGLW 1950
AGQQQELVFL RNRNPERGSI QNAKQALRNM INSSCDQPIG YPIFVSPLTT 2000
SYSDSHEQLK DILGGPISLG NIRNFIVSTW HRLRKGCGAG CNSGGNIEDS 2050
DTGGGTSCTG NNATTANNPH SNVTQGSIGN PGQGSGTGLH PPVTSYPPTL 2100
GTSHSSHSVQ SGLVRQSPAR ASVASQSSYC YSSRHSSLRM STTGFVPCRR 2150
SSTSQISLRN LPSSIQSRLS MVNQMEPSGQ SGLACVQHGL PSSSSSSQSI 2200
PACKHHTLVG FLATEGGQSS ATDAQPGNTL SPANNSHSRK AEVIYRVQIV 2250
DPSQILEGIN LSKRKELQWP DEGIRLKAGR NSWKDWSPQE GMEGHVIHRW 2300
VPCSRDPGTR SHIDKAVLLV QIDDKYVTVI ETGVLELGAE V 2341
Length:2,341
Mass (Da):258,676
Last modified:October 17, 2006 - v2
Checksum:i3C38BD853B2F59D1
GO
Isoform 2 (identifier: Q96RV3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     851-866: RNGSVHLEASHDNASA → SSLLRCMRLVAVICHL
     867-2341: Missing.

Note: No experimental confirmation available.

Show »
Length:866
Mass (Da):93,579
Checksum:i5F52C44695B17D01
GO
Isoform 3 (identifier: Q96RV3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1546-1617: Missing.

Note: No experimental confirmation available.

Show »
Length:2,269
Mass (Da):250,606
Checksum:iAFB883ABABFAB0F5
GO
Isoform 4 (identifier: Q96RV3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     771-876: Missing.
     927-931: Missing.

Note: No experimental confirmation available.

Show »
Length:2,230
Mass (Da):246,976
Checksum:i8947409A0692F3D9
GO

Sequence cautioni

The sequence BAA76839.1 differs from that shown. Reason: Frameshift at position 41.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti594 – 5941A → T.
Corresponds to variant rs34222509 [ dbSNP | Ensembl ].
VAR_050478
Natural varianti809 – 8091L → I.
Corresponds to variant rs11625687 [ dbSNP | Ensembl ].
VAR_028305
Natural varianti814 – 8141L → I.
Corresponds to variant rs11625690 [ dbSNP | Ensembl ].
VAR_028306

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei771 – 876106Missing in isoform 4. VSP_054500Add
BLAST
Alternative sequencei851 – 86616RNGSV…DNASA → SSLLRCMRLVAVICHL in isoform 2. VSP_008401Add
BLAST
Alternative sequencei867 – 23411475Missing in isoform 2. VSP_008402Add
BLAST
Alternative sequencei927 – 9315Missing in isoform 4. VSP_054501
Alternative sequencei1546 – 161772Missing in isoform 3. VSP_008403Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2239 – 22391R → K in AAK82958. 1 Publication
Sequence conflicti2239 – 22391R → K in BAA34525. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF233450 mRNA. Translation: AAK82958.1.
AB023212 mRNA. Translation: BAA76839.1. Frameshift.
AC004825 Genomic DNA. No translation available.
AL445903 Genomic DNA. No translation available.
AC005230 Genomic DNA. No translation available.
AC004817 Genomic DNA. No translation available.
BC017076 mRNA. Translation: AAH17076.2.
BC140784 mRNA. Translation: AAI40785.1.
AB018348 mRNA. Translation: BAA34525.1.
CCDSiCCDS9806.1. [Q96RV3-1]
RefSeqiNP_055797.2. NM_014982.2. [Q96RV3-1]
XP_005267483.1. XM_005267426.2. [Q96RV3-4]
UniGeneiHs.446559.

Genome annotation databases

EnsembliENST00000238570; ENSP00000238570; ENSG00000100731. [Q96RV3-3]
ENST00000304743; ENSP00000304192; ENSG00000100731. [Q96RV3-1]
ENST00000439984; ENSP00000396617; ENSG00000100731.
GeneIDi22990.
KEGGihsa:22990.
UCSCiuc001xmn.4. human. [Q96RV3-2]
uc001xmo.2. human. [Q96RV3-1]

Polymorphism databases

DMDMi116242705.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF233450 mRNA. Translation: AAK82958.1 .
AB023212 mRNA. Translation: BAA76839.1 . Frameshift.
AC004825 Genomic DNA. No translation available.
AL445903 Genomic DNA. No translation available.
AC005230 Genomic DNA. No translation available.
AC004817 Genomic DNA. No translation available.
BC017076 mRNA. Translation: AAH17076.2 .
BC140784 mRNA. Translation: AAI40785.1 .
AB018348 mRNA. Translation: BAA34525.1 .
CCDSi CCDS9806.1. [Q96RV3-1 ]
RefSeqi NP_055797.2. NM_014982.2. [Q96RV3-1 ]
XP_005267483.1. XM_005267426.2. [Q96RV3-4 ]
UniGenei Hs.446559.

3D structure databases

ProteinModelPortali Q96RV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116638. 2 interactions.
IntActi Q96RV3. 2 interactions.

PTM databases

PhosphoSitei Q96RV3.

Polymorphism databases

DMDMi 116242705.

Proteomic databases

MaxQBi Q96RV3.
PaxDbi Q96RV3.
PRIDEi Q96RV3.

Protocols and materials databases

DNASUi 22990.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000238570 ; ENSP00000238570 ; ENSG00000100731 . [Q96RV3-3 ]
ENST00000304743 ; ENSP00000304192 ; ENSG00000100731 . [Q96RV3-1 ]
ENST00000439984 ; ENSP00000396617 ; ENSG00000100731 .
GeneIDi 22990.
KEGGi hsa:22990.
UCSCi uc001xmn.4. human. [Q96RV3-2 ]
uc001xmo.2. human. [Q96RV3-1 ]

Organism-specific databases

CTDi 22990.
GeneCardsi GC14P071374.
H-InvDB HIX0011780.
HGNCi HGNC:19740. PCNX.
HPAi HPA053532.
neXtProti NX_Q96RV3.
PharmGKBi PA134905848.
HUGEi Search...
Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297934.
HOGENOMi HOG000007773.
HOVERGENi HBG045627.
InParanoidi Q96RV3.
OMAi NYRLHRA.
OrthoDBi EOG72VH54.
PhylomeDBi Q96RV3.
TreeFami TF313570.

Miscellaneous databases

ChiTaRSi PCNX. human.
GeneWikii PCNX.
GenomeRNAii 22990.
NextBioi 35468388.
PROi Q96RV3.

Gene expression databases

ArrayExpressi Q96RV3.
Bgeei Q96RV3.
CleanExi HS_PCNX.
Genevestigatori Q96RV3.

Family and domain databases

InterProi IPR007735. Pecanex.
[Graphical view ]
Pfami PF05041. Pecanex_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, mapping and characterization of PCNXL1, a member of a new family of vertebrate homologs of the Drosophila neurogenic gene pecanex."
    Roux A.-F., Gasca S., Bagheri-Fam S., Saridaki A., Sanoudou D., Ferraz C., Demaille J., Ferguson-Smith M., Scherer G.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1803-2341 (ISOFORM 1/2).
    Tissue: Brain and Colon.
  5. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 943-2341 (ISOFORM 3).
    Tissue: Brain.
  6. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiPCX1_HUMAN
AccessioniPrimary (citable) accession number: Q96RV3
Secondary accession number(s): B2RTR6
, O94897, Q96AI7, Q9Y2J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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