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Protein

Tribbles homolog 1

Gene

TRIB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity.1 Publication1 Publication

GO - Molecular functioni

  • mitogen-activated protein kinase kinase binding Source: BHF-UCL
  • protein kinase inhibitor activity Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL
  • ubiquitin-protein transferase regulator activity Source: BHF-UCL

GO - Biological processi

  • JNK cascade Source: BHF-UCL
  • negative regulation of lipopolysaccharide-mediated signaling pathway Source: BHF-UCL
  • negative regulation of neutrophil differentiation Source: Ensembl
  • negative regulation of protein kinase activity Source: BHF-UCL
  • negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  • negative regulation of smooth muscle cell migration Source: BHF-UCL
  • negative regulation of smooth muscle cell proliferation Source: BHF-UCL
  • positive regulation of eosinophil differentiation Source: Ensembl
  • positive regulation of macrophage differentiation Source: Ensembl
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  • regulation of MAP kinase activity Source: UniProtKB
  • response to lipopolysaccharide Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Enzyme and pathway databases

SignaLinkiQ96RU8.

Names & Taxonomyi

Protein namesi
Recommended name:
Tribbles homolog 1
Short name:
TRB-1
Alternative name(s):
G-protein-coupled receptor-induced gene 2 protein
Short name:
GIG-2
SKIP1
Gene namesi
Name:TRIB1Imported
Synonyms:C8FWImported, GIG2Imported, TRB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:16891. TRIB1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • nucleus Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi10221.
OpenTargetsiENSG00000173334.
PharmGKBiPA134963922.

Polymorphism and mutation databases

BioMutaiTRIB1.
DMDMi83305929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001318591 – 372Tribbles homolog 1Add BLAST372

Proteomic databases

EPDiQ96RU8.
MaxQBiQ96RU8.
PaxDbiQ96RU8.
PeptideAtlasiQ96RU8.
PRIDEiQ96RU8.

PTM databases

iPTMnetiQ96RU8.
PhosphoSitePlusiQ96RU8.

Expressioni

Tissue specificityi

Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.1 Publication

Gene expression databases

BgeeiENSG00000173334.
CleanExiHS_TRIB1.
ExpressionAtlasiQ96RU8. baseline and differential.
GenevisibleiQ96RU8. HS.

Organism-specific databases

HPAiHPA053815.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STK40Q8N2I92EBI-492555,EBI-716112

GO - Molecular functioni

  • mitogen-activated protein kinase kinase binding Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi115516. 22 interactors.
DIPiDIP-34542N.
IntActiQ96RU8. 15 interactors.
STRINGi9606.ENSP00000312150.

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi89 – 91Combined sources3
Beta strandi94 – 98Combined sources5
Beta strandi103 – 110Combined sources8
Turni111 – 113Combined sources3
Beta strandi116 – 123Combined sources8
Helixi124 – 130Combined sources7
Helixi132 – 135Combined sources4
Beta strandi137 – 139Combined sources3
Turni141 – 143Combined sources3
Beta strandi146 – 151Combined sources6
Beta strandi153 – 160Combined sources8
Helixi167 – 174Combined sources8
Helixi179 – 198Combined sources20
Helixi208 – 210Combined sources3
Beta strandi211 – 215Combined sources5
Beta strandi221 – 223Combined sources3
Beta strandi240 – 243Combined sources4
Helixi251 – 254Combined sources4
Helixi262 – 279Combined sources18
Helixi289 – 297Combined sources9
Beta strandi305 – 307Combined sources3
Helixi309 – 318Combined sources10
Helixi323 – 325Combined sources3
Helixi329 – 332Combined sources4
Helixi336 – 341Combined sources6
Beta strandi360 – 362Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CEKX-ray2.80A83-343[»]
5CEMX-ray2.10A83-371[»]
5IGOX-ray1.60U/V/W/X354-361[»]
5IGQX-ray3.90U354-364[»]
V/W/X/Y/Z354-361[»]
ProteinModelPortaliQ96RU8.
SMRiQ96RU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 338Protein kinasePROSITE-ProRule annotationAdd BLAST338

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00840000129780.
HOGENOMiHOG000231872.
HOVERGENiHBG067729.
InParanoidiQ96RU8.
KOiK08814.
OMAiCHQSAIV.
OrthoDBiEOG091G07JM.
PhylomeDBiQ96RU8.
TreeFamiTF329785.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024105. TRB1.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF17. PTHR22961:SF17. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96RU8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVGPVRSAM SGASQPRGPA LLFPATRGVP AKRLLDADDA AAVAAKCPRL
60 70 80 90 100
SECSSPPDYL SPPGSPCSPQ PPPAAPGAGG GSGSAPGPSR IADYLLLPLA
110 120 130 140 150
EREHVSRALC IHTGRELRCK VFPIKHYQDK IRPYIQLPSH SNITGIVEVI
160 170 180 190 200
LGETKAYVFF EKDFGDMHSY VRSRKRLREE EAARLFKQIV SAVAHCHQSA
210 220 230 240 250
IVLGDLKLRK FVFSTEERTQ LRLESLEDTH IMKGEDDALS DKHGCPAYVS
260 270 280 290 300
PEILNTTGTY SGKAADVWSL GVMLYTLLVG RYPFHDSDPS ALFSKIRRGQ
310 320 330 340 350
FCIPEHISPK ARCLIRSLLR REPSERLTAP EILLHPWFES VLEPGYIDSE
360 370
IGTSDQIVPE YQEDSDISSF FC
Length:372
Mass (Da):41,009
Last modified:December 6, 2005 - v2
Checksum:i5F54E50924B1365B
GO
Isoform 2 (identifier: Q96RU8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.

Note: No experimental confirmation available.
Show »
Length:206
Mass (Da):23,473
Checksum:i0B6CE8BD11BBC895
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149 – 150VI → SV in CAA04119 (PubMed:9342215).Curated2
Sequence conflicti163D → S (PubMed:15299019).Curated1
Sequence conflicti163D → S (PubMed:9342215).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042364173S → R.1 PublicationCorresponds to variant rs56285697dbSNPEnsembl.1
Natural variantiVAR_042365215T → M.1 PublicationCorresponds to variant rs34349706dbSNPEnsembl.1
Natural variantiVAR_042366267V → I.1 PublicationCorresponds to variant rs56056430dbSNPEnsembl.1
Natural variantiVAR_042367298R → C.1 PublicationCorresponds to variant rs55953723dbSNPEnsembl.1
Natural variantiVAR_042368360E → A.1 PublicationCorresponds to variant rs35454769dbSNPEnsembl.1
Natural variantiVAR_042369360E → D.1 PublicationCorresponds to variant rs16900603dbSNPEnsembl.1
Natural variantiVAR_042370371F → L in a lung large cell carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0548941 – 166Missing in isoform 2. 1 PublicationAdd BLAST166

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250310 mRNA. Translation: AAK58174.1.
AF205437 mRNA. Translation: AAG35663.1.
AK297539 mRNA. Translation: BAG59938.1.
AL832388 mRNA. Translation: CAI46181.1.
FJ515869 Genomic DNA. Translation: ACS13752.1.
AC091114 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW92085.1.
BC063292 mRNA. Translation: AAH63292.1.
AJ000480 mRNA. Translation: CAA04119.1.
CCDSiCCDS6357.1. [Q96RU8-1]
CCDS64971.1. [Q96RU8-2]
RefSeqiNP_001269914.1. NM_001282985.1. [Q96RU8-2]
NP_079471.1. NM_025195.3. [Q96RU8-1]
UniGeneiHs.444947.

Genome annotation databases

EnsembliENST00000311922; ENSP00000312150; ENSG00000173334. [Q96RU8-1]
ENST00000520847; ENSP00000429063; ENSG00000173334. [Q96RU8-2]
GeneIDi10221.
KEGGihsa:10221.
UCSCiuc003yrx.4. human. [Q96RU8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250310 mRNA. Translation: AAK58174.1.
AF205437 mRNA. Translation: AAG35663.1.
AK297539 mRNA. Translation: BAG59938.1.
AL832388 mRNA. Translation: CAI46181.1.
FJ515869 Genomic DNA. Translation: ACS13752.1.
AC091114 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW92085.1.
BC063292 mRNA. Translation: AAH63292.1.
AJ000480 mRNA. Translation: CAA04119.1.
CCDSiCCDS6357.1. [Q96RU8-1]
CCDS64971.1. [Q96RU8-2]
RefSeqiNP_001269914.1. NM_001282985.1. [Q96RU8-2]
NP_079471.1. NM_025195.3. [Q96RU8-1]
UniGeneiHs.444947.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CEKX-ray2.80A83-343[»]
5CEMX-ray2.10A83-371[»]
5IGOX-ray1.60U/V/W/X354-361[»]
5IGQX-ray3.90U354-364[»]
V/W/X/Y/Z354-361[»]
ProteinModelPortaliQ96RU8.
SMRiQ96RU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115516. 22 interactors.
DIPiDIP-34542N.
IntActiQ96RU8. 15 interactors.
STRINGi9606.ENSP00000312150.

PTM databases

iPTMnetiQ96RU8.
PhosphoSitePlusiQ96RU8.

Polymorphism and mutation databases

BioMutaiTRIB1.
DMDMi83305929.

Proteomic databases

EPDiQ96RU8.
MaxQBiQ96RU8.
PaxDbiQ96RU8.
PeptideAtlasiQ96RU8.
PRIDEiQ96RU8.

Protocols and materials databases

DNASUi10221.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311922; ENSP00000312150; ENSG00000173334. [Q96RU8-1]
ENST00000520847; ENSP00000429063; ENSG00000173334. [Q96RU8-2]
GeneIDi10221.
KEGGihsa:10221.
UCSCiuc003yrx.4. human. [Q96RU8-1]

Organism-specific databases

CTDi10221.
DisGeNETi10221.
GeneCardsiTRIB1.
HGNCiHGNC:16891. TRIB1.
HPAiHPA053815.
MIMi609461. gene.
neXtProtiNX_Q96RU8.
OpenTargetsiENSG00000173334.
PharmGKBiPA134963922.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00840000129780.
HOGENOMiHOG000231872.
HOVERGENiHBG067729.
InParanoidiQ96RU8.
KOiK08814.
OMAiCHQSAIV.
OrthoDBiEOG091G07JM.
PhylomeDBiQ96RU8.
TreeFamiTF329785.

Enzyme and pathway databases

SignaLinkiQ96RU8.

Miscellaneous databases

ChiTaRSiTRIB1. human.
GeneWikiiTRIB1.
GenomeRNAii10221.
PROiQ96RU8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173334.
CleanExiHS_TRIB1.
ExpressionAtlasiQ96RU8. baseline and differential.
GenevisibleiQ96RU8. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024105. TRB1.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF17. PTHR22961:SF17. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRIB1_HUMAN
AccessioniPrimary (citable) accession number: Q96RU8
Secondary accession number(s): B4DMM6
, C5HU08, O15180, Q9H2Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.