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Q96RU8

- TRIB1_HUMAN

UniProt

Q96RU8 - TRIB1_HUMAN

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Protein

Tribbles homolog 1

Gene

TRIB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity.1 Publication1 Publication

GO - Molecular functioni

  1. mitogen-activated protein kinase kinase binding Source: BHF-UCL
  2. protein kinase inhibitor activity Source: BHF-UCL
  3. transcription factor binding Source: BHF-UCL
  4. transferase activity, transferring phosphorus-containing groups Source: InterPro
  5. ubiquitin protein ligase binding Source: BHF-UCL
  6. ubiquitin-protein transferase regulator activity Source: BHF-UCL

GO - Biological processi

  1. JNK cascade Source: BHF-UCL
  2. negative regulation of lipopolysaccharide-mediated signaling pathway Source: BHF-UCL
  3. negative regulation of protein kinase activity Source: BHF-UCL
  4. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  5. negative regulation of smooth muscle cell migration Source: BHF-UCL
  6. negative regulation of smooth muscle cell proliferation Source: BHF-UCL
  7. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  8. regulation of MAP kinase activity Source: UniProtKB
  9. response to lipopolysaccharide Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Enzyme and pathway databases

SignaLinkiQ96RU8.

Names & Taxonomyi

Protein namesi
Recommended name:
Tribbles homolog 1
Short name:
TRB-1
Alternative name(s):
G-protein-coupled receptor-induced gene 2 protein
Short name:
GIG-2
SKIP1
Gene namesi
Name:TRIB1Imported
Synonyms:C8FWImported, GIG2Imported, TRB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:16891. TRIB1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. nucleus Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134963922.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Tribbles homolog 1PRO_0000131859Add
BLAST

Proteomic databases

MaxQBiQ96RU8.
PaxDbiQ96RU8.
PRIDEiQ96RU8.

PTM databases

PhosphoSiteiQ96RU8.

Expressioni

Tissue specificityi

Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.1 Publication

Gene expression databases

BgeeiQ96RU8.
CleanExiHS_TRIB1.
ExpressionAtlasiQ96RU8. baseline and differential.
GenevestigatoriQ96RU8.

Organism-specific databases

HPAiHPA053815.

Interactioni

Protein-protein interaction databases

BioGridi115516. 7 interactions.
IntActiQ96RU8. 5 interactions.
STRINGi9606.ENSP00000312150.

Structurei

3D structure databases

ProteinModelPortaliQ96RU8.
SMRiQ96RU8. Positions 91-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 338338Protein kinasePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119244.
HOGENOMiHOG000231872.
HOVERGENiHBG067729.
InParanoidiQ96RU8.
KOiK08814.
OMAiAHCHQSA.
OrthoDBiEOG7RJPR4.
PhylomeDBiQ96RU8.
TreeFamiTF329785.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024105. TRB1.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF10. PTHR22961:SF10. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96RU8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVGPVRSAM SGASQPRGPA LLFPATRGVP AKRLLDADDA AAVAAKCPRL
60 70 80 90 100
SECSSPPDYL SPPGSPCSPQ PPPAAPGAGG GSGSAPGPSR IADYLLLPLA
110 120 130 140 150
EREHVSRALC IHTGRELRCK VFPIKHYQDK IRPYIQLPSH SNITGIVEVI
160 170 180 190 200
LGETKAYVFF EKDFGDMHSY VRSRKRLREE EAARLFKQIV SAVAHCHQSA
210 220 230 240 250
IVLGDLKLRK FVFSTEERTQ LRLESLEDTH IMKGEDDALS DKHGCPAYVS
260 270 280 290 300
PEILNTTGTY SGKAADVWSL GVMLYTLLVG RYPFHDSDPS ALFSKIRRGQ
310 320 330 340 350
FCIPEHISPK ARCLIRSLLR REPSERLTAP EILLHPWFES VLEPGYIDSE
360 370
IGTSDQIVPE YQEDSDISSF FC
Length:372
Mass (Da):41,009
Last modified:December 6, 2005 - v2
Checksum:i5F54E50924B1365B
GO
Isoform 2 (identifier: Q96RU8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.

Note: No experimental confirmation available.

Show »
Length:206
Mass (Da):23,473
Checksum:i0B6CE8BD11BBC895
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1502VI → SV in CAA04119. (PubMed:9342215)Curated
Sequence conflicti163 – 1631D → S(PubMed:15299019)Curated
Sequence conflicti163 – 1631D → S(PubMed:9342215)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti173 – 1731S → R.1 Publication
Corresponds to variant rs56285697 [ dbSNP | Ensembl ].
VAR_042364
Natural varianti215 – 2151T → M.1 Publication
Corresponds to variant rs34349706 [ dbSNP | Ensembl ].
VAR_042365
Natural varianti267 – 2671V → I.1 Publication
Corresponds to variant rs56056430 [ dbSNP | Ensembl ].
VAR_042366
Natural varianti298 – 2981R → C.1 Publication
Corresponds to variant rs55953723 [ dbSNP | Ensembl ].
VAR_042367
Natural varianti360 – 3601E → A.1 Publication
Corresponds to variant rs35454769 [ dbSNP | Ensembl ].
VAR_042368
Natural varianti360 – 3601E → D.1 Publication
Corresponds to variant rs16900603 [ dbSNP | Ensembl ].
VAR_042369
Natural varianti371 – 3711F → L in a lung large cell carcinoma sample; somatic mutation. 1 Publication
VAR_042370

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 166166Missing in isoform 2. 1 PublicationVSP_054894Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250310 mRNA. Translation: AAK58174.1.
AF205437 mRNA. Translation: AAG35663.1.
AK297539 mRNA. Translation: BAG59938.1.
AL832388 mRNA. Translation: CAI46181.1.
FJ515869 Genomic DNA. Translation: ACS13752.1.
AC091114 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW92085.1.
BC063292 mRNA. Translation: AAH63292.1.
AJ000480 mRNA. Translation: CAA04119.1.
CCDSiCCDS6357.1. [Q96RU8-1]
CCDS64971.1. [Q96RU8-2]
RefSeqiNP_001269914.1. NM_001282985.1. [Q96RU8-2]
NP_079471.1. NM_025195.3. [Q96RU8-1]
XP_006716560.1. XM_006716497.1. [Q96RU8-2]
UniGeneiHs.444947.

Genome annotation databases

EnsembliENST00000311922; ENSP00000312150; ENSG00000173334. [Q96RU8-1]
ENST00000520847; ENSP00000429063; ENSG00000173334. [Q96RU8-2]
GeneIDi10221.
KEGGihsa:10221.
UCSCiuc003yrx.3. human. [Q96RU8-1]

Polymorphism databases

DMDMi83305929.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250310 mRNA. Translation: AAK58174.1 .
AF205437 mRNA. Translation: AAG35663.1 .
AK297539 mRNA. Translation: BAG59938.1 .
AL832388 mRNA. Translation: CAI46181.1 .
FJ515869 Genomic DNA. Translation: ACS13752.1 .
AC091114 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW92085.1 .
BC063292 mRNA. Translation: AAH63292.1 .
AJ000480 mRNA. Translation: CAA04119.1 .
CCDSi CCDS6357.1. [Q96RU8-1 ]
CCDS64971.1. [Q96RU8-2 ]
RefSeqi NP_001269914.1. NM_001282985.1. [Q96RU8-2 ]
NP_079471.1. NM_025195.3. [Q96RU8-1 ]
XP_006716560.1. XM_006716497.1. [Q96RU8-2 ]
UniGenei Hs.444947.

3D structure databases

ProteinModelPortali Q96RU8.
SMRi Q96RU8. Positions 91-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115516. 7 interactions.
IntActi Q96RU8. 5 interactions.
STRINGi 9606.ENSP00000312150.

PTM databases

PhosphoSitei Q96RU8.

Polymorphism databases

DMDMi 83305929.

Proteomic databases

MaxQBi Q96RU8.
PaxDbi Q96RU8.
PRIDEi Q96RU8.

Protocols and materials databases

DNASUi 10221.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311922 ; ENSP00000312150 ; ENSG00000173334 . [Q96RU8-1 ]
ENST00000520847 ; ENSP00000429063 ; ENSG00000173334 . [Q96RU8-2 ]
GeneIDi 10221.
KEGGi hsa:10221.
UCSCi uc003yrx.3. human. [Q96RU8-1 ]

Organism-specific databases

CTDi 10221.
GeneCardsi GC08P126442.
HGNCi HGNC:16891. TRIB1.
HPAi HPA053815.
MIMi 609461. gene.
neXtProti NX_Q96RU8.
PharmGKBi PA134963922.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119244.
HOGENOMi HOG000231872.
HOVERGENi HBG067729.
InParanoidi Q96RU8.
KOi K08814.
OMAi AHCHQSA.
OrthoDBi EOG7RJPR4.
PhylomeDBi Q96RU8.
TreeFami TF329785.

Enzyme and pathway databases

SignaLinki Q96RU8.

Miscellaneous databases

ChiTaRSi TRIB1. human.
GeneWikii TRIB1.
GenomeRNAii 10221.
NextBioi 35473372.
PROi Q96RU8.
SOURCEi Search...

Gene expression databases

Bgeei Q96RU8.
CleanExi HS_TRIB1.
ExpressionAtlasi Q96RU8. baseline and differential.
Genevestigatori Q96RU8.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024105. TRB1.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view ]
PANTHERi PTHR22961. PTHR22961. 1 hit.
PTHR22961:SF10. PTHR22961:SF10. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH MAP2K1 AND MAP2K4.
  2. "Identification of a novel nuclear factor Gig2, as an m1-acetylcholine receptor-induced gene."
    Mayhaus M., von der Kammer H., Klaudiny J., Albrecht C., Hoffmann B., Nitsch R.M.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph node.
  5. NHLBI resequencing and genotyping service (RS&G)
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: PlacentaImported.
  9. "Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells."
    Wilkin F., Suarez-Huerta N., Robaye B., Peetermans J., Libert F., Dumont J.E., Maenhaut C.
    Eur. J. Biochem. 248:660-668(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 149-372 (ISOFORM 1).
    Tissue: ThyroidImported.
  10. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-173; MET-215; ILE-267; CYS-298; ALA-360; ASP-360 AND LEU-371.

Entry informationi

Entry nameiTRIB1_HUMAN
AccessioniPrimary (citable) accession number: Q96RU8
Secondary accession number(s): B4DMM6
, C5HU08, O15180, Q9H2Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 26, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3