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Protein

Gamma-tubulin complex component 5

Gene

TUBGCP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

GO - Molecular functioni

  • gamma-tubulin binding Source: GO_Central
  • microtubule binding Source: UniProtKB
  • structural constituent of cytoskeleton Source: GO_Central

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153575-MONOMER.
ReactomeiR-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-380320. Recruitment of NuMA to mitotic centrosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex component 5
Short name:
GCP-5
Gene namesi
Name:TUBGCP5
Synonyms:GCP5, KIAA1899
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:18600. TUBGCP5.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • equatorial microtubule organizing center Source: GO_Central
  • gamma-tubulin ring complex Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • spindle pole Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi114791.
OpenTargetsiENSG00000275835.
PharmGKBiPA38599.

Polymorphism and mutation databases

BioMutaiTUBGCP5.
DMDMi20454926.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000781291 – 1024Gamma-tubulin complex component 5Add BLAST1024

Proteomic databases

EPDiQ96RT8.
MaxQBiQ96RT8.
PaxDbiQ96RT8.
PeptideAtlasiQ96RT8.
PRIDEiQ96RT8.

PTM databases

iPTMnetiQ96RT8.
PhosphoSitePlusiQ96RT8.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in heart and skeletal muscle and moderate levels in brain.1 Publication

Gene expression databases

BgeeiENSG00000153575.
CleanExiHS_TUBGCP5.
ExpressionAtlasiQ96RT8. baseline and differential.
GenevisibleiQ96RT8. HS.

Organism-specific databases

HPAiHPA039366.
HPA040366.

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.

GO - Molecular functioni

  • gamma-tubulin binding Source: GO_Central
  • microtubule binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125353. 32 interactors.
IntActiQ96RT8. 26 interactors.
MINTiMINT-4989249.
STRINGi9606.ENSP00000283645.

Structurei

3D structure databases

ProteinModelPortaliQ96RT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

eggNOGiKOG4344. Eukaryota.
ENOG410ZYW9. LUCA.
GeneTreeiENSGT00850000132278.
HOGENOMiHOG000290706.
HOVERGENiHBG025895.
InParanoidiQ96RT8.
KOiK16572.
OrthoDBiEOG091G0ABS.
PhylomeDBiQ96RT8.
TreeFamiTF329759.

Family and domain databases

InterProiIPR007259. GCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 1 hit.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96RT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARHGPPWSR LDAQQERDVR ELVRGVAGLQ DEADPNFQLA LNFAWSNFRF
60 70 80 90 100
HRFLDVNSHK IEKTIEGIYE KFVIHSDLSK AASWKRLTEE FLNAPLPSIK
110 120 130 140 150
EIKTDAHYSI LSLLLCLSDS PSNSSYVETP RNKEVEKKDD FDWGKYLMED
160 170 180 190 200
EEMDIGPYMD TPNWSEESEE ENDQQPLSRE DSGIQVDRTP LEEQDQNRKL
210 220 230 240 250
DPCISWKDEP DDRSWLEHHV VHQYWTARPS QFPHSLHLHS NLAAVWDQHL
260 270 280 290 300
YSSDPLYVPD DRVLVTETQV IRETLWLLSG VKKLFIFQLI DGKVTVRNNI
310 320 330 340 350
IVTHLTHSCL RSVLEQIAAY GQVVFRLQEF IDEVMGHSSE SMLPGSGSVP
360 370 380 390 400
KKSTEAPFRT YQAFMWALYK YFISFKEELA EIEKCIINND TTITLAIVVD
410 420 430 440 450
KLAPRLSQLK VLHKVFSTGV AEVPPDTRNV VRASHLLNTL YKAILEYDNV
460 470 480 490 500
GEASEQTVSL LFSLWVETVR PYLQTVDEWI VHGHLWDGAR EFIIQRNKNV
510 520 530 540 550
PVNHRDFWYA TYTLYSVSEK TENEEKMSDN ASASSGSDQG PSSRQHTMVS
560 570 580 590 600
FLKPVLKQII MAGKSMQLLK NLQCAESTTC QAGARDAERK SLYTLFLESV
610 620 630 640 650
QSRLRHGEDS TPQVLTEQQA TKENLMKMQS IAESHLELDD VHDPLLAINF
660 670 680 690 700
ARMYLEQSDF HEKFAGGDVC VDRSSESVTC QTFELTLRSC LYPHIDKQYL
710 720 730 740 750
DCCGNLMQTL KKDYRLVEYL QAMRNFFLME GGDTMYDFYT SIFDKIREKE
760 770 780 790 800
TWQNVSFLNV QLQEAVGQRY PEDSSRLSIS FENVDTAKKK LPVHILDGLT
810 820 830 840 850
LSYKVPWPVD IVISLECQKI YNQVFLLLLQ IKWAKYSLDV LLFGELVSTA
860 870 880 890 900
EKPRLKEGLI HEQDTVAQFG PQKEPVRQQI HRMFLLRVKL MHFVNSLHNY
910 920 930 940 950
IMTRILHSTG LEFQHQVEEA KDLDQLIKIH YRYLSTIHDR CLLREKVSFV
960 970 980 990 1000
KEAIMKVLNL ALMFADGWQA GLGTWRMESI EKMESDFKNC HMFLVTILNK
1010 1020
AVCRGSFPHL ESLALSLMAG MEQS
Length:1,024
Mass (Da):118,321
Last modified:December 1, 2001 - v1
Checksum:i21350677DF126CD1
GO
Isoform 2 (identifier: Q96RT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1010-1024: LESLALSLMAGMEQS → CEYIMLKYFYLCISL

Note: No experimental confirmation available.
Show »
Length:1,024
Mass (Da):118,643
Checksum:i6CDE6207A9F6EF6E
GO

Sequence cautioni

The sequence AAH46182 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK056416 differs from that shown. Reason: Frameshift at position 713.Curated
The sequence AK056416 differs from that shown. Reason: Erroneous termination at position 405. Translated as Arg.Curated
The sequence BAB67792 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198R → G in AAH71560 (PubMed:15489334).Curated1
Sequence conflicti994L → F in AK056416 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049252662E → D.Corresponds to variant rs35612840dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0474961010 – 1024LESLA…GMEQS → CEYIMLKYFYLCISL in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272884 mRNA. Translation: AAK77662.1.
AB067486 mRNA. Translation: BAB67792.2. Different initiation.
AK056416 mRNA. No translation available.
AC116166 Genomic DNA. No translation available.
BC046182 mRNA. Translation: AAH46182.1. Different initiation.
BC071560 mRNA. Translation: AAH71560.1.
CCDSiCCDS73697.1. [Q96RT8-2]
CCDS73698.1. [Q96RT8-1]
RefSeqiNP_001096080.1. NM_001102610.1. [Q96RT8-2]
NP_443135.3. NM_052903.4. [Q96RT8-1]
UniGeneiHs.533898.

Genome annotation databases

EnsembliENST00000615383; ENSP00000480316; ENSG00000275835. [Q96RT8-1]
ENST00000620435; ENSP00000481853; ENSG00000275835. [Q96RT8-2]
GeneIDi114791.
KEGGihsa:114791.
UCSCiuc001yuq.3. human. [Q96RT8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272884 mRNA. Translation: AAK77662.1.
AB067486 mRNA. Translation: BAB67792.2. Different initiation.
AK056416 mRNA. No translation available.
AC116166 Genomic DNA. No translation available.
BC046182 mRNA. Translation: AAH46182.1. Different initiation.
BC071560 mRNA. Translation: AAH71560.1.
CCDSiCCDS73697.1. [Q96RT8-2]
CCDS73698.1. [Q96RT8-1]
RefSeqiNP_001096080.1. NM_001102610.1. [Q96RT8-2]
NP_443135.3. NM_052903.4. [Q96RT8-1]
UniGeneiHs.533898.

3D structure databases

ProteinModelPortaliQ96RT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125353. 32 interactors.
IntActiQ96RT8. 26 interactors.
MINTiMINT-4989249.
STRINGi9606.ENSP00000283645.

PTM databases

iPTMnetiQ96RT8.
PhosphoSitePlusiQ96RT8.

Polymorphism and mutation databases

BioMutaiTUBGCP5.
DMDMi20454926.

Proteomic databases

EPDiQ96RT8.
MaxQBiQ96RT8.
PaxDbiQ96RT8.
PeptideAtlasiQ96RT8.
PRIDEiQ96RT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000615383; ENSP00000480316; ENSG00000275835. [Q96RT8-1]
ENST00000620435; ENSP00000481853; ENSG00000275835. [Q96RT8-2]
GeneIDi114791.
KEGGihsa:114791.
UCSCiuc001yuq.3. human. [Q96RT8-1]

Organism-specific databases

CTDi114791.
DisGeNETi114791.
GeneCardsiTUBGCP5.
HGNCiHGNC:18600. TUBGCP5.
HPAiHPA039366.
HPA040366.
MIMi608147. gene.
neXtProtiNX_Q96RT8.
OpenTargetsiENSG00000275835.
PharmGKBiPA38599.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4344. Eukaryota.
ENOG410ZYW9. LUCA.
GeneTreeiENSGT00850000132278.
HOGENOMiHOG000290706.
HOVERGENiHBG025895.
InParanoidiQ96RT8.
KOiK16572.
OrthoDBiEOG091G0ABS.
PhylomeDBiQ96RT8.
TreeFamiTF329759.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153575-MONOMER.
ReactomeiR-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-380320. Recruitment of NuMA to mitotic centrosomes.

Miscellaneous databases

ChiTaRSiTUBGCP5. human.
GeneWikiiTUBGCP5.
GenomeRNAii114791.
PROiQ96RT8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153575.
CleanExiHS_TUBGCP5.
ExpressionAtlasiQ96RT8. baseline and differential.
GenevisibleiQ96RT8. HS.

Family and domain databases

InterProiIPR007259. GCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 1 hit.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCP5_HUMAN
AccessioniPrimary (citable) accession number: Q96RT8
Secondary accession number(s): E9PB12, Q6IQ52, Q96PY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.