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Q96RT6

- CTGE2_HUMAN

UniProt

Q96RT6 - CTGE2_HUMAN

Protein

cTAGE family member 2

Gene

CTAGE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cTAGE family member 2
    Short name:
    Protein cTAGE-2
    Alternative name(s):
    Cancer/testis antigen 21.2
    Short name:
    CT21.2
    Gene namesi
    Name:CTAGE1
    Synonyms:CTAGE2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:24346. CTAGE1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134933936.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 745745cTAGE family member 2PRO_0000189538Add
    BLAST

    Proteomic databases

    PaxDbiQ96RT6.
    PRIDEiQ96RT6.

    PTM databases

    PhosphoSiteiQ96RT6.

    Expressioni

    Tissue specificityi

    Testis. Not found in tumor.

    Gene expression databases

    ArrayExpressiQ96RT6.
    BgeeiQ96RT6.
    CleanExiHS_CTAGE1.
    GenevestigatoriQ96RT6.

    Organism-specific databases

    HPAiCAB016204.
    HPA000387.
    HPA000922.

    Interactioni

    Protein-protein interaction databases

    BioGridi122233. 3 interactions.
    IntActiQ96RT6. 1 interaction.
    MINTiMINT-7970856.
    STRINGi9606.ENSP00000375220.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96RT6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3018HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili84 – 254171Sequence AnalysisAdd
    BLAST
    Coiled coili290 – 411122Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi658 – 74386Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cTAGE family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGibiNOG13452.
    HOVERGENiHBG051216.
    OMAiRGPFIRR.
    OrthoDBiEOG74TWXQ.
    PhylomeDBiQ96RT6.
    TreeFamiTF333137.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms (cTAGE-1B, cTAGE-1C and cTAGE-2s) exist.

    Isoform 2 (identifier: Q96RT6-1) [UniParc]FASTAAdd to Basket

    Also known as: cTAGE-2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRPDSHPYGF PWELVIRAAV AGFFAVLFLW RSFRSVTSRL YVRREKKFAV    50
    ALSGLIEEKC KLLEKFSLVQ KEYEGYEVES SLKNASFEKE ATEAQSLEAT 100
    CEKLNRFNSE LVHEILCLEK ELKEEKSKHS EQNELMADIS KRIQSLEDES 150
    KSLKSQVAEA KMTFKRFQAN EERLEIEIQD AWKENSELQE SQKQLLQEAE 200
    VWKEQVSELI KQKRTFEDSK VHAEQVLNDK ENHIKTLTER LLKMKDGVAM 250
    LEEDVTDDDN LELEMNSESE DGAYLDNPPK GALKKLIHAA KLNASLKTLE 300
    GERNQIYIQL SEVDKTKEEL TEHIKNLQTE QASLQSENTH FESENQKLQQ 350
    KLKVMTELYQ ENEMKLYRKL IVEEKCRLEK EEKLSKVDEM ISHATEELET 400
    YRKRAKDLKE FEKTIHFYQK KIILHEKKAH DNWSAAWTAE RNLNDLRKEN 450
    AHNRQKLTEI EFKIKLLEKD PYGLDVPNTA FGRQHSPYGP SPLGWPSSET 500
    RASLYPPTLL EGPLRLSPLL PRGGGRGSRG PGNPPDHQIT KERGESSCDR 550
    LTDPHRAPSD AGPLAPPWEQ DYRMMFPPPG QSYPDSALPP QRQDRFYSNC 600
    ARLSGPAELR SFNMPSLDKM DGSMPSEMES SRNDTKDNLG NLKVPDSSLP 650
    AENEATGPGF VPPPLAPIRG LLFPVDTRGP FIRRGPPFPP PPPGTVFGAS 700
    PDYFSPRDVP GPPRAPFAMR NVYLPRGFLP YRPPRPAFFP PAPTF 745
    Length:745
    Mass (Da):85,282
    Last modified:October 14, 2008 - v2
    Checksum:iE3E6B1219651CA61
    GO
    Isoform 1 (identifier: Q9HC47-1) [UniParc]FASTAAdd to Basket

    Also known as: cTAGE-1

    The sequence of this isoform can be found in the external entry Q9HC47.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:74
    Mass (Da):8,406
    GO

    Sequence cautioni

    The sequence AAK63198.1 differs from that shown. Reason: Frameshift at position 741.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti179 – 1791Q → R in AAK63198. (PubMed:12839582)Curated
    Sequence conflicti312 – 3121E → G in AAK63198. (PubMed:12839582)Curated
    Sequence conflicti430 – 4301H → R in AAK63198. (PubMed:12839582)Curated
    Sequence conflicti635 – 6351T → A in AAK63198. (PubMed:12839582)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti682 – 6821I → V.
    Corresponds to variant rs9946136 [ dbSNP | Ensembl ].
    VAR_046956

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF273058 mRNA. Translation: AAK63198.1. Frameshift.
    AC099849 Genomic DNA. No translation available.
    BC132871 mRNA. Translation: AAI32872.1.
    CCDSiCCDS45837.1. [Q96RT6-1]
    RefSeqiNP_758441.2. NM_172241.2. [Q96RT6-1]
    UniGeneiHs.406709.

    Genome annotation databases

    EnsembliENST00000391403; ENSP00000375220; ENSG00000212710. [Q96RT6-1]
    GeneIDi64693.
    KEGGihsa:64693.
    UCSCiuc002ktv.1. human. [Q96RT6-1]

    Polymorphism databases

    DMDMi209572622.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF273058 mRNA. Translation: AAK63198.1 . Frameshift.
    AC099849 Genomic DNA. No translation available.
    BC132871 mRNA. Translation: AAI32872.1 .
    CCDSi CCDS45837.1. [Q96RT6-1 ]
    RefSeqi NP_758441.2. NM_172241.2. [Q96RT6-1 ]
    UniGenei Hs.406709.

    3D structure databases

    ProteinModelPortali Q96RT6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122233. 3 interactions.
    IntActi Q96RT6. 1 interaction.
    MINTi MINT-7970856.
    STRINGi 9606.ENSP00000375220.

    PTM databases

    PhosphoSitei Q96RT6.

    Polymorphism databases

    DMDMi 209572622.

    Proteomic databases

    PaxDbi Q96RT6.
    PRIDEi Q96RT6.

    Protocols and materials databases

    DNASUi 64693.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000391403 ; ENSP00000375220 ; ENSG00000212710 . [Q96RT6-1 ]
    GeneIDi 64693.
    KEGGi hsa:64693.
    UCSCi uc002ktv.1. human. [Q96RT6-1 ]

    Organism-specific databases

    CTDi 64693.
    GeneCardsi GC18M019995.
    H-InvDB HIX0014361.
    HIX0037399.
    HGNCi HGNC:24346. CTAGE1.
    HPAi CAB016204.
    HPA000387.
    HPA000922.
    MIMi 608856. gene.
    neXtProti NX_Q96RT6.
    PharmGKBi PA134933936.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi biNOG13452.
    HOVERGENi HBG051216.
    OMAi RGPFIRR.
    OrthoDBi EOG74TWXQ.
    PhylomeDBi Q96RT6.
    TreeFami TF333137.

    Miscellaneous databases

    GenomeRNAii 64693.
    NextBioi 66615.
    PROi Q96RT6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96RT6.
    Bgeei Q96RT6.
    CleanExi HS_CTAGE1.
    Genevestigatori Q96RT6.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing."
      Usener D., Schadendorf D., Koch J., Duebel S., Eichmueller S.
      J. Invest. Dermatol. 121:198-206(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCTGE2_HUMAN
    AccessioniPrimary (citable) accession number: Q96RT6
    Secondary accession number(s): A2RUF2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3