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Q96RT6 (CTGE2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
cTAGE family member 2

Short name=Protein cTAGE-2
Alternative name(s):
Cancer/testis antigen 21.2
Short name=CT21.2
Gene names
Name:CTAGE1
Synonyms:CTAGE2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length745 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Tissue specificity

Testis. Not found in tumor.

Sequence similarities

Belongs to the cTAGE family.

Sequence caution

The sequence AAK63198.1 differs from that shown. Reason: Frameshift at position 741.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms (cTAGE-1B, cTAGE-1C and cTAGE-2s) exist.
Isoform 2 (identifier: Q96RT6-1)

Also known as: cTAGE-2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: Q9HC47-1)

Also known as: cTAGE-1;

The sequence of this isoform can be found in the external entry Q9HC47.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 745745cTAGE family member 2
PRO_0000189538

Regions

Transmembrane13 – 3018Helical; Potential
Coiled coil84 – 254171 Potential
Coiled coil290 – 411122 Potential
Compositional bias658 – 74386Pro-rich

Natural variations

Natural variant6821I → V.
Corresponds to variant rs9946136 [ dbSNP | Ensembl ].
VAR_046956

Experimental info

Sequence conflict1791Q → R in AAK63198. Ref.1
Sequence conflict3121E → G in AAK63198. Ref.1
Sequence conflict4301H → R in AAK63198. Ref.1
Sequence conflict6351T → A in AAK63198. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 (cTAGE-2) [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: E3E6B1219651CA61

FASTA74585,282
        10         20         30         40         50         60 
MRPDSHPYGF PWELVIRAAV AGFFAVLFLW RSFRSVTSRL YVRREKKFAV ALSGLIEEKC 

        70         80         90        100        110        120 
KLLEKFSLVQ KEYEGYEVES SLKNASFEKE ATEAQSLEAT CEKLNRFNSE LVHEILCLEK 

       130        140        150        160        170        180 
ELKEEKSKHS EQNELMADIS KRIQSLEDES KSLKSQVAEA KMTFKRFQAN EERLEIEIQD 

       190        200        210        220        230        240 
AWKENSELQE SQKQLLQEAE VWKEQVSELI KQKRTFEDSK VHAEQVLNDK ENHIKTLTER 

       250        260        270        280        290        300 
LLKMKDGVAM LEEDVTDDDN LELEMNSESE DGAYLDNPPK GALKKLIHAA KLNASLKTLE 

       310        320        330        340        350        360 
GERNQIYIQL SEVDKTKEEL TEHIKNLQTE QASLQSENTH FESENQKLQQ KLKVMTELYQ 

       370        380        390        400        410        420 
ENEMKLYRKL IVEEKCRLEK EEKLSKVDEM ISHATEELET YRKRAKDLKE FEKTIHFYQK 

       430        440        450        460        470        480 
KIILHEKKAH DNWSAAWTAE RNLNDLRKEN AHNRQKLTEI EFKIKLLEKD PYGLDVPNTA 

       490        500        510        520        530        540 
FGRQHSPYGP SPLGWPSSET RASLYPPTLL EGPLRLSPLL PRGGGRGSRG PGNPPDHQIT 

       550        560        570        580        590        600 
KERGESSCDR LTDPHRAPSD AGPLAPPWEQ DYRMMFPPPG QSYPDSALPP QRQDRFYSNC 

       610        620        630        640        650        660 
ARLSGPAELR SFNMPSLDKM DGSMPSEMES SRNDTKDNLG NLKVPDSSLP AENEATGPGF 

       670        680        690        700        710        720 
VPPPLAPIRG LLFPVDTRGP FIRRGPPFPP PPPGTVFGAS PDYFSPRDVP GPPRAPFAMR 

       730        740 
NVYLPRGFLP YRPPRPAFFP PAPTF 

« Hide

Isoform 1 (cTAGE-1) [UniParc].

See Q9HC47.

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF273058 mRNA. Translation: AAK63198.1. Frameshift.
AC099849 Genomic DNA. No translation available.
BC132871 mRNA. Translation: AAI32872.1.
RefSeqNP_758441.2. NM_172241.2.
UniGeneHs.406709.

3D structure databases

ProteinModelPortalQ96RT6.
SMRQ96RT6. Positions 46-129, 401-430.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122233. 3 interactions.
IntActQ96RT6. 1 interaction.
MINTMINT-7970856.
STRING9606.ENSP00000375220.

PTM databases

PhosphoSiteQ96RT6.

Polymorphism databases

DMDM209572622.

Proteomic databases

PaxDbQ96RT6.
PRIDEQ96RT6.

Protocols and materials databases

DNASU64693.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000391403; ENSP00000375220; ENSG00000212710. [Q96RT6-1]
GeneID64693.
KEGGhsa:64693.
UCSCuc002ktv.1. human. [Q96RT6-1]

Organism-specific databases

CTD64693.
GeneCardsGC18M019995.
H-InvDBHIX0014361.
HIX0037399.
HGNCHGNC:24346. CTAGE1.
HPACAB016204.
HPA000387.
HPA000922.
MIM608856. gene.
neXtProtNX_Q96RT6.
PharmGKBPA134933936.
GenAtlasSearch...

Phylogenomic databases

eggNOGbiNOG13452.
HOVERGENHBG051216.
OMARGPFIRR.
OrthoDBEOG74TWXQ.
PhylomeDBQ96RT6.
TreeFamTF333137.

Gene expression databases

ArrayExpressQ96RT6.
BgeeQ96RT6.
CleanExHS_CTAGE1.
GenevestigatorQ96RT6.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi64693.
NextBio66615.
PROQ96RT6.
SOURCESearch...

Entry information

Entry nameCTGE2_HUMAN
AccessionPrimary (citable) accession number: Q96RT6
Secondary accession number(s): A2RUF2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 14, 2008
Last modified: April 16, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM