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Protein

cTAGE family member 2

Gene

CTAGE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
cTAGE family member 2
Short name:
Protein cTAGE-2
Alternative name(s):
Cancer/testis antigen 21.2
Short name:
CT21.2
Gene namesi
Name:CTAGE1
Synonyms:CTAGE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:24346. CTAGE1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3018HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134933936.

Polymorphism and mutation databases

BioMutaiGATA6.
DMDMi209572622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745cTAGE family member 2PRO_0000189538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei267 – 2671Phosphoserine1 Publication
Modified residuei517 – 5171PhosphoserineBy similarity
Modified residuei647 – 6471PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96RT6.
PRIDEiQ96RT6.

PTM databases

PhosphoSiteiQ96RT6.

Expressioni

Tissue specificityi

Testis. Not found in tumor.

Gene expression databases

BgeeiQ96RT6.
CleanExiHS_CTAGE1.
ExpressionAtlasiQ96RT6. baseline and differential.
GenevisibleiQ96RT6. HS.

Organism-specific databases

HPAiCAB016204.
HPA000387.
HPA000922.

Interactioni

Protein-protein interaction databases

BioGridi122233. 3 interactions.
IntActiQ96RT6. 1 interaction.
MINTiMINT-7970856.
STRINGi9606.ENSP00000375220.

Structurei

3D structure databases

ProteinModelPortaliQ96RT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili84 – 254171Sequence AnalysisAdd
BLAST
Coiled coili290 – 411122Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi658 – 74386Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the cTAGE family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGibiNOG13452.
GeneTreeiENSGT00530000063635.
HOVERGENiHBG051216.
InParanoidiQ96RT6.
OMAiPWEIVIC.
OrthoDBiEOG74TWXQ.
PhylomeDBiQ96RT6.
TreeFamiTF333137.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms (cTAGE-1B, cTAGE-1C and cTAGE-2s) exist.

Isoform 2 (identifier: Q96RT6-1) [UniParc]FASTAAdd to basket

Also known as: cTAGE-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPDSHPYGF PWELVIRAAV AGFFAVLFLW RSFRSVTSRL YVRREKKFAV
60 70 80 90 100
ALSGLIEEKC KLLEKFSLVQ KEYEGYEVES SLKNASFEKE ATEAQSLEAT
110 120 130 140 150
CEKLNRFNSE LVHEILCLEK ELKEEKSKHS EQNELMADIS KRIQSLEDES
160 170 180 190 200
KSLKSQVAEA KMTFKRFQAN EERLEIEIQD AWKENSELQE SQKQLLQEAE
210 220 230 240 250
VWKEQVSELI KQKRTFEDSK VHAEQVLNDK ENHIKTLTER LLKMKDGVAM
260 270 280 290 300
LEEDVTDDDN LELEMNSESE DGAYLDNPPK GALKKLIHAA KLNASLKTLE
310 320 330 340 350
GERNQIYIQL SEVDKTKEEL TEHIKNLQTE QASLQSENTH FESENQKLQQ
360 370 380 390 400
KLKVMTELYQ ENEMKLYRKL IVEEKCRLEK EEKLSKVDEM ISHATEELET
410 420 430 440 450
YRKRAKDLKE FEKTIHFYQK KIILHEKKAH DNWSAAWTAE RNLNDLRKEN
460 470 480 490 500
AHNRQKLTEI EFKIKLLEKD PYGLDVPNTA FGRQHSPYGP SPLGWPSSET
510 520 530 540 550
RASLYPPTLL EGPLRLSPLL PRGGGRGSRG PGNPPDHQIT KERGESSCDR
560 570 580 590 600
LTDPHRAPSD AGPLAPPWEQ DYRMMFPPPG QSYPDSALPP QRQDRFYSNC
610 620 630 640 650
ARLSGPAELR SFNMPSLDKM DGSMPSEMES SRNDTKDNLG NLKVPDSSLP
660 670 680 690 700
AENEATGPGF VPPPLAPIRG LLFPVDTRGP FIRRGPPFPP PPPGTVFGAS
710 720 730 740
PDYFSPRDVP GPPRAPFAMR NVYLPRGFLP YRPPRPAFFP PAPTF
Length:745
Mass (Da):85,282
Last modified:October 14, 2008 - v2
Checksum:iE3E6B1219651CA61
GO
Isoform 1 (identifier: Q9HC47-1) [UniParc]FASTAAdd to basket

Also known as: cTAGE-1

The sequence of this isoform can be found in the external entry Q9HC47.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:74
Mass (Da):8,406
GO

Sequence cautioni

The sequence AAK63198.1 differs from that shown. Reason: Frameshift at position 741. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791Q → R in AAK63198 (PubMed:12839582).Curated
Sequence conflicti312 – 3121E → G in AAK63198 (PubMed:12839582).Curated
Sequence conflicti430 – 4301H → R in AAK63198 (PubMed:12839582).Curated
Sequence conflicti635 – 6351T → A in AAK63198 (PubMed:12839582).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti682 – 6821I → V.
Corresponds to variant rs9946136 [ dbSNP | Ensembl ].
VAR_046956

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273058 mRNA. Translation: AAK63198.1. Frameshift.
AC099849 Genomic DNA. No translation available.
BC132871 mRNA. Translation: AAI32872.1.
CCDSiCCDS45837.1. [Q96RT6-1]
RefSeqiNP_758441.2. NM_172241.2. [Q96RT6-1]
UniGeneiHs.406709.

Genome annotation databases

EnsembliENST00000391403; ENSP00000375220; ENSG00000212710. [Q96RT6-1]
GeneIDi64693.
KEGGihsa:64693.
UCSCiuc002ktv.1. human. [Q96RT6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273058 mRNA. Translation: AAK63198.1. Frameshift.
AC099849 Genomic DNA. No translation available.
BC132871 mRNA. Translation: AAI32872.1.
CCDSiCCDS45837.1. [Q96RT6-1]
RefSeqiNP_758441.2. NM_172241.2. [Q96RT6-1]
UniGeneiHs.406709.

3D structure databases

ProteinModelPortaliQ96RT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122233. 3 interactions.
IntActiQ96RT6. 1 interaction.
MINTiMINT-7970856.
STRINGi9606.ENSP00000375220.

PTM databases

PhosphoSiteiQ96RT6.

Polymorphism and mutation databases

BioMutaiGATA6.
DMDMi209572622.

Proteomic databases

PaxDbiQ96RT6.
PRIDEiQ96RT6.

Protocols and materials databases

DNASUi64693.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391403; ENSP00000375220; ENSG00000212710. [Q96RT6-1]
GeneIDi64693.
KEGGihsa:64693.
UCSCiuc002ktv.1. human. [Q96RT6-1]

Organism-specific databases

CTDi64693.
GeneCardsiGC18M019995.
H-InvDBHIX0014361.
HIX0037399.
HGNCiHGNC:24346. CTAGE1.
HPAiCAB016204.
HPA000387.
HPA000922.
MIMi608856. gene.
neXtProtiNX_Q96RT6.
PharmGKBiPA134933936.
GenAtlasiSearch...

Phylogenomic databases

eggNOGibiNOG13452.
GeneTreeiENSGT00530000063635.
HOVERGENiHBG051216.
InParanoidiQ96RT6.
OMAiPWEIVIC.
OrthoDBiEOG74TWXQ.
PhylomeDBiQ96RT6.
TreeFamiTF333137.

Miscellaneous databases

GenomeRNAii64693.
NextBioi66615.
SOURCEiSearch...

Gene expression databases

BgeeiQ96RT6.
CleanExiHS_CTAGE1.
ExpressionAtlasiQ96RT6. baseline and differential.
GenevisibleiQ96RT6. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing."
    Usener D., Schadendorf D., Koch J., Duebel S., Eichmueller S.
    J. Invest. Dermatol. 121:198-206(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCTGE2_HUMAN
AccessioniPrimary (citable) accession number: Q96RT6
Secondary accession number(s): A2RUF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 14, 2008
Last modified: June 24, 2015
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.