Q96RT6 (CTGE2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein cTAGE-2

Alternative name(s):
Cancer/testis antigen 21.2
Short name=CT21.2

Gene names

Name:	CTAGE1
Synonyms:	CTAGE2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	745 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Testis. Not found in tumor.
Sequence similarities	Belongs to the cTAGE family.
Sequence caution	The sequence AAK63198.1 differs from that shown. Reason: Frameshift at position 741.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms (cTAGE-1B, cTAGE-1C and cTAGE-2s) exist.

Isoform 2 (identifier: Q96RT6-1)

Also known as: cTAGE-2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q9HC47-1)

Also known as: cTAGE-1;

The sequence of this isoform can be found in the external entry Q9HC47.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 745	745	Protein cTAGE-2		PRO_0000189538
Regions
	Transmembrane	13 – 30	18	Helical; Potential
	Coiled coil	84 – 254	171	Potential
	Coiled coil	290 – 411	122	Potential
	Compositional bias	658 – 743	86	Pro-rich
Natural variations
	Natural variant	682	1	I → V. Corresponds to variant rs9946136 [ dbSNP | Ensembl ].		VAR_046956
Experimental info
	Sequence conflict	179	1	Q → R in AAK63198. Ref.1
	Sequence conflict	312	1	E → G in AAK63198. Ref.1
	Sequence conflict	430	1	H → R in AAK63198. Ref.1
	Sequence conflict	635	1	T → A in AAK63198. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 (cTAGE-2) [UniParc]. Last modified October 14, 2008. Version 2. Checksum: E3E6B1219651CA61	FASTA	745	85,282
	10 20 30 40 50 60 MRPDSHPYGF PWELVIRAAV AGFFAVLFLW RSFRSVTSRL YVRREKKFAV ALSGLIEEKC 70 80 90 100 110 120 KLLEKFSLVQ KEYEGYEVES SLKNASFEKE ATEAQSLEAT CEKLNRFNSE LVHEILCLEK 130 140 150 160 170 180 ELKEEKSKHS EQNELMADIS KRIQSLEDES KSLKSQVAEA KMTFKRFQAN EERLEIEIQD 190 200 210 220 230 240 AWKENSELQE SQKQLLQEAE VWKEQVSELI KQKRTFEDSK VHAEQVLNDK ENHIKTLTER 250 260 270 280 290 300 LLKMKDGVAM LEEDVTDDDN LELEMNSESE DGAYLDNPPK GALKKLIHAA KLNASLKTLE 310 320 330 340 350 360 GERNQIYIQL SEVDKTKEEL TEHIKNLQTE QASLQSENTH FESENQKLQQ KLKVMTELYQ 370 380 390 400 410 420 ENEMKLYRKL IVEEKCRLEK EEKLSKVDEM ISHATEELET YRKRAKDLKE FEKTIHFYQK 430 440 450 460 470 480 KIILHEKKAH DNWSAAWTAE RNLNDLRKEN AHNRQKLTEI EFKIKLLEKD PYGLDVPNTA 490 500 510 520 530 540 FGRQHSPYGP SPLGWPSSET RASLYPPTLL EGPLRLSPLL PRGGGRGSRG PGNPPDHQIT 550 560 570 580 590 600 KERGESSCDR LTDPHRAPSD AGPLAPPWEQ DYRMMFPPPG QSYPDSALPP QRQDRFYSNC 610 620 630 640 650 660 ARLSGPAELR SFNMPSLDKM DGSMPSEMES SRNDTKDNLG NLKVPDSSLP AENEATGPGF 670 680 690 700 710 720 VPPPLAPIRG LLFPVDTRGP FIRRGPPFPP PPPGTVFGAS PDYFSPRDVP GPPRAPFAMR 730 740 NVYLPRGFLP YRPPRPAFFP PAPTF
	Isoform 1 (cTAGE-1) [UniParc]. See Q9HC47.		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing." Usener D., Schadendorf D., Koch J., Duebel S., Eichmueller S. J. Invest. Dermatol. 121:198-206(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Testis.
[2]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF273058 mRNA. Translation: AAK63198.1. Frameshift. AC099849 Genomic DNA. No translation available. BC132871 mRNA. Translation: AAI32872.1.
IPI	IPI00400827.
RefSeq	NP_758441.2. NM_172241.2.
UniGene	Hs.406709.
3D structure databases
ProteinModelPortal	Q96RT6.
SMR	Q96RT6. Positions 323-349, 437-463.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000375220.
PTM databases
PhosphoSite	Q96RT6.
Polymorphism databases
DMDM	209572622.
Proteomic databases
PaxDb	Q96RT6.
PRIDE	Q96RT6.
Protocols and materials databases
DNASU	64693.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000391403; ENSP00000375220; ENSG00000212710.
GeneID	64693.
KEGG	hsa:64693.
UCSC	uc002ktv.1. human.
Organism-specific databases
CTD	64693.
GeneCards	GC18M019995.
H-InvDB	HIX0014361. HIX0037399.
HGNC	HGNC:24346. CTAGE1.
HPA	CAB016204. HPA000387. HPA000922.
MIM	608856. gene.
neXtProt	NX_Q96RT6.
PharmGKB	PA134933936.
GenAtlas	Search...
Phylogenomic databases
eggNOG	biNOG13452.
HOVERGEN	HBG051216.
OMA	RGPFIRR.
OrthoDB	EOG43XV59.
Gene expression databases
ArrayExpress	Q96RT6.
Bgee	Q96RT6.
CleanEx	HS_CTAGE1.
Genevestigator	Q96RT6.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	64693.
NextBio	66615.
SOURCE	Search...

Entry information

Entry name

CTGE2_HUMAN

Accession

Primary (citable) accession number: Q96RT6
Secondary accession number(s): A2RUF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	October 14, 2008
Last modified:	April 3, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.