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Protein

Erbin

Gene

ERBIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).2 Publications

GO - Molecular functioni

  • ErbB-2 class receptor binding Source: UniProtKB
  • integrin binding Source: UniProtKB
  • receptor binding Source: UniProtKB
  • structural constituent of cytoskeleton Source: UniProtKB

GO - Biological processi

  • basal protein localization Source: UniProtKB
  • cell adhesion Source: UniProtKB
  • cell cycle Source: UniProtKB
  • cell growth Source: UniProtKB
  • cellular response to tumor necrosis factor Source: UniProtKB
  • epidermal growth factor receptor signaling pathway Source: UniProtKB
  • ERBB2 signaling pathway Source: Reactome
  • establishment or maintenance of epithelial cell apical/basal polarity Source: UniProtKB
  • integrin-mediated signaling pathway Source: UniProtKB
  • intermediate filament cytoskeleton organization Source: UniProtKB
  • negative regulation of monocyte chemotactic protein-1 production Source: Ensembl
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway Source: UniProtKB
  • protein targeting Source: Ensembl
  • response to lipopolysaccharide Source: UniProtKB
  • response to muramyl dipeptide Source: UniProtKB
  • signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-1227986. Signaling by ERBB2.
R-HSA-8863795. Downregulation of ERBB2 signaling.
SignaLinkiQ96RT1.

Names & Taxonomyi

Protein namesi
Recommended name:
Erbin1 Publication
Alternative name(s):
Densin-180-like protein
Erbb2-interacting protein1 Publication
Protein LAP2
Gene namesi
Name:ERBIN1 Publication
Synonyms:ERBB2IP1 Publication, KIAA1225Imported, LAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:15842. ERBIN.

Subcellular locationi

GO - Cellular componenti

  • basal plasma membrane Source: UniProtKB
  • basement membrane Source: ProtInc
  • basolateral plasma membrane Source: UniProtKB
  • cell junction Source: HPA
  • cytoplasm Source: UniProtKB
  • hemidesmosome Source: UniProtKB
  • nuclear membrane Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55914.
OpenTargetsiENSG00000112851.
PharmGKBiPA27845.

Polymorphism and mutation databases

BioMutaiERBB2IP.
DMDMi116242614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001883011 – 1412ErbinAdd BLAST1412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei440PhosphoserineCombined sources1
Modified residuei444PhosphoserineBy similarity1
Modified residuei483PhosphotyrosineBy similarity1
Modified residuei485PhosphothreonineCombined sources1
Modified residuei569PhosphoserineCombined sources1
Modified residuei598PhosphoserineBy similarity1
Modified residuei602PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Modified residuei620PhosphoserineCombined sources1
Modified residuei715PhosphoserineBy similarity1
Modified residuei852PhosphoserineCombined sources1
Modified residuei857PhosphoserineCombined sources1
Modified residuei872PhosphoserineCombined sources1
Modified residuei917PhosphothreonineCombined sources1
Modified residuei920PhosphotyrosineCombined sources1
Modified residuei931PhosphoserineCombined sources1
Modified residuei972PhosphotyrosineCombined sources1
Modified residuei1104PhosphotyrosineBy similarity1
Modified residuei1158PhosphoserineCombined sources1
Modified residuei1179PhosphoserineCombined sources1
Modified residuei1286PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96RT1.
MaxQBiQ96RT1.
PaxDbiQ96RT1.
PeptideAtlasiQ96RT1.
PRIDEiQ96RT1.

PTM databases

iPTMnetiQ96RT1.
PhosphoSitePlusiQ96RT1.
SwissPalmiQ96RT1.

Expressioni

Tissue specificityi

Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.1 Publication

Gene expression databases

BgeeiENSG00000112851.
CleanExiHS_ERBB2IP.
ExpressionAtlasiQ96RT1. baseline and differential.
GenevisibleiQ96RT1. HS.

Organism-specific databases

HPAiHPA048606.
HPA059863.

Interactioni

Subunit structurei

Interacts with ERBB2, BPAG1 and ITGB4 (PubMed:10878805, PubMed:11375975, PubMed:12444095). May favor the localization of ERBB2, by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin (PubMed:11821434). Interacts (via C-terminus) with DST Isoform 3 (via N-terminus) (PubMed:11375975). Interacts with NOD2 (via CARD domain) (PubMed:16203728).6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NOD2Q9HC295EBI-8449250,EBI-7445625
PKP4Q995694EBI-8449250,EBI-726447

GO - Molecular functioni

  • ErbB-2 class receptor binding Source: UniProtKB
  • integrin binding Source: UniProtKB
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120997. 103 interactors.
IntActiQ96RT1. 35 interactors.
MINTiMINT-199447.
STRINGi9606.ENSP00000370330.

Structurei

Secondary structure

11412
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1318 – 1327Combined sources10
Beta strandi1329 – 1331Combined sources3
Beta strandi1333 – 1338Combined sources6
Turni1339 – 1342Combined sources4
Beta strandi1346 – 1348Combined sources3
Beta strandi1353 – 1359Combined sources7
Turni1364 – 1368Combined sources5
Beta strandi1374 – 1378Combined sources5
Helixi1388 – 1397Combined sources10
Beta strandi1400 – 1410Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MFGX-ray1.25A1321-1412[»]
1MFLX-ray1.88A1321-1412[»]
1N7TNMR-A1314-1412[»]
2H3LX-ray1.00A/B1314-1412[»]
2QBWX-ray1.80A1330-1410[»]
3CH8X-ray1.90A1330-1410[»]
ProteinModelPortaliQ96RT1.
SMRiQ96RT1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96RT1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 44LRR 1Add BLAST22
Repeati47 – 68LRR 2Add BLAST22
Repeati70 – 91LRR 3Add BLAST22
Repeati93 – 114LRR 4Add BLAST22
Repeati116 – 137LRR 5Add BLAST22
Repeati139 – 161LRR 6Add BLAST23
Repeati162 – 183LRR 7Add BLAST22
Repeati185 – 206LRR 8Add BLAST22
Repeati208 – 229LRR 9Add BLAST22
Repeati231 – 252LRR 10Add BLAST22
Repeati254 – 275LRR 11Add BLAST22
Repeati277 – 298LRR 12Add BLAST22
Repeati300 – 321LRR 13Add BLAST22
Repeati323 – 344LRR 14Add BLAST22
Repeati346 – 367LRR 15Add BLAST22
Repeati369 – 391LRR 16Add BLAST23
Repeati392 – 413LRR 17Add BLAST22
Domaini1321 – 1410PDZPROSITE-ProRule annotationAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi930 – 934Poly-Ser5

Sequence similaritiesi

Belongs to the LAP (LRR and PDZ) protein family.Curated
Contains 17 LRR (leucine-rich) repeats.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KCZ0. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000060229.
HOVERGENiHBG052305.
InParanoidiQ96RT1.
KOiK12796.
OMAiKNMVKTV.
OrthoDBiEOG091G01EF.
PhylomeDBiQ96RT1.
TreeFamiTF351429.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR032927. Erbin.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR23155:SF421. PTHR23155:SF421. 1 hit.
PfamiPF13855. LRR_8. 4 hits.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 15 hits.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96RT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE
60 70 80 90 100
LYLDANQIEE LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS
110 120 130 140 150
KNGIQEFPEN IKNCKVLTIV EASVNPISKL PDGFSQLLNL TQLYLNDAFL
160 170 180 190 200
EFLPANFGRL TKLQILELRE NQLKMLPKTM NRLTQLERLD LGSNEFTEVP
210 220 230 240 250
EVLEQLSGLK EFWMDANRLT FIPGFIGSLK QLTYLDVSKN NIEMVEEGIS
260 270 280 290 300
TCENLQDLLL SSNSLQQLPE TIGSLKNITT LKIDENQLMY LPDSIGGLIS
310 320 330 340 350
VEELDCSFNE VEALPSSIGQ LTNLRTFAAD HNYLQQLPPE IGSWKNITVL
360 370 380 390 400
FLHSNKLETL PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD
410 420 430 440 450
NQSKPLIPLQ KETDSETQKM VLTNYMFPQQ PRTEDVMFIS DNESFNPSLW
460 470 480 490 500
EEQRKQRAQV AFECDEDKDE REAPPREGNL KRYPTPYPDE LKNMVKTVQT
510 520 530 540 550
IVHRLKDEET NEDSGRDLKP HEDQQDINKD VGVKTSESTT TVKSKVDERE
560 570 580 590 600
KYMIGNSVQK ISEPEAEISP GSLPVTANMK ASENLKHIVN HDDVFEESEE
610 620 630 640 650
LSSDEEMKMA EMRPPLIETS INQPKVVALS NNKKDDTKET DSLSDEVTHN
660 670 680 690 700
SNQNNSNCSS PSRMSDSVSL NTDSSQDTSL CSPVKQTHID INSKIRQEDE
710 720 730 740 750
NFNSLLQNGD ILNSSTEEKF KAHDKKDFNL PEYDLNVEER LVLIEKSVDS
760 770 780 790 800
TATADDTHKL DHINMNLNKL ITNDTFQPEI MERSKTQDIV LGTSFLSINS
810 820 830 840 850
KEETEHLENG NKYPNLESVN KVNGHSEETS QSPNRTEPHD SDCSVDLGIS
860 870 880 890 900
KSTEDLSPQK SGPVGSVVKS HSITNMEIGG LKIYDILSDN GPQQPSTTVK
910 920 930 940 950
ITSAVDGKNI VRSKSATLLY DQPLQVFTGS SSSSDLISGT KAIFKFDSNH
960 970 980 990 1000
NPEEPNIIRG PTSGPQSAPQ IYGPPQYNIQ YSSSAAVKDT LWHSKQNPQI
1010 1020 1030 1040 1050
DHASFPPQLL PRSESTENQS YAKHSANMNF SNHNNVRANT AYHLHQRLGP
1060 1070 1080 1090 1100
ARHGEMWAIS PNDRLIPAVT RSTIQRQSSV SSTASVNLGD PGSTRRAQIP
1110 1120 1130 1140 1150
EGDYLSYREF HSAGRTPPMM PGSQRPLSAR TYSIDGPNAS RPQSARPSIN
1160 1170 1180 1190 1200
EIPERTMSVS DFNYSRTSPS KRPNARVGSE HSLLDPPGKS KVPRDWREQV
1210 1220 1230 1240 1250
LRHIEAKKLE KKHPQTSSSG DPCQDGIFIS GQQNYSSATL SHKDVPPDSL
1260 1270 1280 1290 1300
MKMPLSNGQM GQPLRPQANY SQIHHPPQAS VARHPSREQL IDYLMLKVAH
1310 1320 1330 1340 1350
QPPYTQPHCS PRQGHELAKQ EIRVRVEKDP ELGFSISGGV GGRGNPFRPD
1360 1370 1380 1390 1400
DDGIFVTRVQ PEGPASKLLQ PGDKIIQANG YSFINIEHGQ AVSLLKTFQN
1410
TVELIIVREV SS
Length:1,412
Mass (Da):158,298
Last modified:October 17, 2006 - v2
Checksum:i304DFC81578CF671
GO
Isoform 2 (identifier: Q96RT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.

Show »
Length:1,371
Mass (Da):153,926
Checksum:iC8F24683B0C4324D
GO
Isoform 3 (identifier: Q96RT1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1268-1278: Missing.

Show »
Length:1,360
Mass (Da):152,653
Checksum:iA56B9384680DA710
GO
Isoform 4 (identifier: Q96RT1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1353-1377: Missing.

Show »
Length:1,346
Mass (Da):151,252
Checksum:i19D7B81B5A934C2E
GO
Isoform 5 (identifier: Q96RT1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1253-1267: Missing.

Show »
Length:1,356
Mass (Da):152,290
Checksum:i9662C85F03C8F08B
GO
Isoform 6 (identifier: Q96RT1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1322-1352: Missing.

Show »
Length:1,340
Mass (Da):150,602
Checksum:i12B24ADE16A5F537
GO
Isoform 7 (identifier: Q96RT1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1253-1267: Missing.
     1268-1278: Missing.
     1279-1321: Missing.

Show »
Length:1,302
Mass (Da):146,086
Checksum:iE436063ACDA2C1A4
GO
Isoform 8 (identifier: Q96RT1-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: KHPQTSSSGD...KDVPPDSLMK → SMLSRSFNSN...RRGSGGHIFR

Note: No experimental confirmation available.
Show »
Length:1,419
Mass (Da):159,024
Checksum:i9E18163421DBE278
GO
Isoform 9 (identifier: Q96RT1-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     531-534: Missing.
     1212-1252: Missing.

Note: No experimental confirmation available.
Show »
Length:1,367
Mass (Da):153,543
Checksum:iC1F031AD4CA0746B
GO

Sequence cautioni

The sequence AAH50692 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91538 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271T → P in AAI15013 (PubMed:15489334).Curated1
Sequence conflicti547D → G in AAI15013 (PubMed:15489334).Curated1
Sequence conflicti805E → G in BAA91538 (PubMed:14702039).Curated1
Sequence conflicti813Y → C in AAK69431 (PubMed:11375975).Curated1
Sequence conflicti848G → C in BAG65463 (PubMed:14702039).Curated1
Sequence conflicti1047R → S in BAG65463 (PubMed:14702039).Curated1
Sequence conflicti1205E → G in AAI15013 (PubMed:15489334).Curated1
Sequence conflicti1267Q → P in AAI15013 (PubMed:15489334).Curated1
Sequence conflicti1328K → R in AAI15013 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019346274S → L.1 PublicationCorresponds to variant rs3213837dbSNPEnsembl.1
Natural variantiVAR_068905313A → V.1 PublicationCorresponds to variant rs191137999dbSNPEnsembl.1
Natural variantiVAR_028304746K → E.Corresponds to variant rs16894812dbSNPEnsembl.1
Natural variantiVAR_046673914K → R.Corresponds to variant rs34521887dbSNPEnsembl.1
Natural variantiVAR_0466741089G → V.Corresponds to variant rs35601230dbSNPEnsembl.1
Natural variantiVAR_0193471112S → L.Corresponds to variant rs3805466dbSNPEnsembl.1
Natural variantiVAR_0193481207K → E.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047389531 – 534Missing in isoform 9. 1 Publication4
Alternative sequenceiVSP_0108021212 – 1252Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 9. 5 PublicationsAdd BLAST41
Alternative sequenceiVSP_0445361212 – 1252KHPQT…DSLMK → SMLSRSFNSNFTTVSSFHCG SSRDLHGSQGSLALSVADRR GSGGHIFR in isoform 8. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_0108031253 – 1267Missing in isoform 5 and isoform 7. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0108041268 – 1278Missing in isoform 3 and isoform 7. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0108051279 – 1321Missing in isoform 7. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_0108061322 – 1352Missing in isoform 6. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0108071353 – 1377Missing in isoform 4. 2 PublicationsAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263744 mRNA. Translation: AAF77048.1.
AF276423 mRNA. Translation: AAK69431.1.
AB033051 mRNA. Translation: BAA86539.2.
AK001180 mRNA. Translation: BAA91538.1. Different initiation.
AK304693 mRNA. Translation: BAG65463.1.
AC010359 Genomic DNA. No translation available.
AC025442 Genomic DNA. No translation available.
BC050692 mRNA. Translation: AAH50692.1. Sequence problems.
BC115012 mRNA. Translation: AAI15013.1.
BC126464 mRNA. Translation: AAI26465.1.
BC144075 mRNA. Translation: AAI44076.1.
CCDSiCCDS34172.1. [Q96RT1-7]
CCDS3990.1. [Q96RT1-2]
CCDS58951.1. [Q96RT1-9]
CCDS58952.1. [Q96RT1-8]
CCDS58953.1. [Q96RT1-1]
CCDS58954.1. [Q96RT1-4]
RefSeqiNP_001006600.1. NM_001006600.2. [Q96RT1-7]
NP_001240626.1. NM_001253697.1. [Q96RT1-1]
NP_001240627.1. NM_001253698.1. [Q96RT1-4]
NP_001240628.1. NM_001253699.1. [Q96RT1-8]
NP_001240630.1. NM_001253701.1. [Q96RT1-9]
NP_061165.1. NM_018695.3. [Q96RT1-2]
UniGeneiHs.591774.
Hs.597241.

Genome annotation databases

EnsembliENST00000284037; ENSP00000284037; ENSG00000112851. [Q96RT1-1]
ENST00000380935; ENSP00000370322; ENSG00000112851. [Q96RT1-7]
ENST00000380938; ENSP00000370325; ENSG00000112851. [Q96RT1-4]
ENST00000380943; ENSP00000370330; ENSG00000112851. [Q96RT1-2]
ENST00000506030; ENSP00000426632; ENSG00000112851. [Q96RT1-8]
ENST00000508515; ENSP00000422015; ENSG00000112851. [Q96RT1-7]
ENST00000511297; ENSP00000422766; ENSG00000112851. [Q96RT1-9]
GeneIDi55914.
KEGGihsa:55914.
UCSCiuc003jui.3. human. [Q96RT1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263744 mRNA. Translation: AAF77048.1.
AF276423 mRNA. Translation: AAK69431.1.
AB033051 mRNA. Translation: BAA86539.2.
AK001180 mRNA. Translation: BAA91538.1. Different initiation.
AK304693 mRNA. Translation: BAG65463.1.
AC010359 Genomic DNA. No translation available.
AC025442 Genomic DNA. No translation available.
BC050692 mRNA. Translation: AAH50692.1. Sequence problems.
BC115012 mRNA. Translation: AAI15013.1.
BC126464 mRNA. Translation: AAI26465.1.
BC144075 mRNA. Translation: AAI44076.1.
CCDSiCCDS34172.1. [Q96RT1-7]
CCDS3990.1. [Q96RT1-2]
CCDS58951.1. [Q96RT1-9]
CCDS58952.1. [Q96RT1-8]
CCDS58953.1. [Q96RT1-1]
CCDS58954.1. [Q96RT1-4]
RefSeqiNP_001006600.1. NM_001006600.2. [Q96RT1-7]
NP_001240626.1. NM_001253697.1. [Q96RT1-1]
NP_001240627.1. NM_001253698.1. [Q96RT1-4]
NP_001240628.1. NM_001253699.1. [Q96RT1-8]
NP_001240630.1. NM_001253701.1. [Q96RT1-9]
NP_061165.1. NM_018695.3. [Q96RT1-2]
UniGeneiHs.591774.
Hs.597241.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MFGX-ray1.25A1321-1412[»]
1MFLX-ray1.88A1321-1412[»]
1N7TNMR-A1314-1412[»]
2H3LX-ray1.00A/B1314-1412[»]
2QBWX-ray1.80A1330-1410[»]
3CH8X-ray1.90A1330-1410[»]
ProteinModelPortaliQ96RT1.
SMRiQ96RT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120997. 103 interactors.
IntActiQ96RT1. 35 interactors.
MINTiMINT-199447.
STRINGi9606.ENSP00000370330.

PTM databases

iPTMnetiQ96RT1.
PhosphoSitePlusiQ96RT1.
SwissPalmiQ96RT1.

Polymorphism and mutation databases

BioMutaiERBB2IP.
DMDMi116242614.

Proteomic databases

EPDiQ96RT1.
MaxQBiQ96RT1.
PaxDbiQ96RT1.
PeptideAtlasiQ96RT1.
PRIDEiQ96RT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284037; ENSP00000284037; ENSG00000112851. [Q96RT1-1]
ENST00000380935; ENSP00000370322; ENSG00000112851. [Q96RT1-7]
ENST00000380938; ENSP00000370325; ENSG00000112851. [Q96RT1-4]
ENST00000380943; ENSP00000370330; ENSG00000112851. [Q96RT1-2]
ENST00000506030; ENSP00000426632; ENSG00000112851. [Q96RT1-8]
ENST00000508515; ENSP00000422015; ENSG00000112851. [Q96RT1-7]
ENST00000511297; ENSP00000422766; ENSG00000112851. [Q96RT1-9]
GeneIDi55914.
KEGGihsa:55914.
UCSCiuc003jui.3. human. [Q96RT1-1]

Organism-specific databases

CTDi55914.
DisGeNETi55914.
GeneCardsiERBB2IP.
HGNCiHGNC:15842. ERBIN.
HPAiHPA048606.
HPA059863.
MIMi606944. gene.
neXtProtiNX_Q96RT1.
OpenTargetsiENSG00000112851.
PharmGKBiPA27845.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCZ0. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000060229.
HOVERGENiHBG052305.
InParanoidiQ96RT1.
KOiK12796.
OMAiKNMVKTV.
OrthoDBiEOG091G01EF.
PhylomeDBiQ96RT1.
TreeFamiTF351429.

Enzyme and pathway databases

ReactomeiR-HSA-1227986. Signaling by ERBB2.
R-HSA-8863795. Downregulation of ERBB2 signaling.
SignaLinkiQ96RT1.

Miscellaneous databases

ChiTaRSiERBB2IP. human.
EvolutionaryTraceiQ96RT1.
GeneWikiiErbin_(protein).
GenomeRNAii55914.
PROiQ96RT1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112851.
CleanExiHS_ERBB2IP.
ExpressionAtlasiQ96RT1. baseline and differential.
GenevisibleiQ96RT1. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR032927. Erbin.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR23155:SF421. PTHR23155:SF421. 1 hit.
PfamiPF13855. LRR_8. 4 hits.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 15 hits.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERBIN_HUMAN
AccessioniPrimary (citable) accession number: Q96RT1
Secondary accession number(s): A0AVR1
, B4E3F1, B7ZLV9, E7EQW9, E9PCR8, Q1RMD0, Q86W38, Q9NR18, Q9NW48, Q9ULJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.