Q96RT1 (LAP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein LAP2

Alternative name(s):
Densin-180-like protein
Erbb2-interacting protein
Short name=Erbin

Gene names

Name:	ERBB2IP
Synonyms:	ERBIN, KIAA1225, LAP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1412 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Ref.1
Subunit structure	Interacts with ERBB2, BPAG1 and ITGB4. May favor the localization of ERBB2, by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin. Interacts (via C-terminus) with DST Isoform 3 (via N-terminus). Ref.1 Ref.2 Ref.8
Subcellular location	Cell junction › hemidesmosome. Nucleus membrane By similarity. Note: Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes By similarity. Ref.1 Ref.2
Tissue specificity	Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine. Ref.1
Sequence similarities	Belongs to the LAP (LRR and PDZ) protein family. Contains 17 LRR (leucine-rich) repeats. Contains 1 PDZ (DHR) domain.
Sequence caution	The sequence AAH50692.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAA91538.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cell junction Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Leucine-rich repeat Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	basal protein localization Non-traceable author statement Ref.2. Source: UniProtKB cell adhesion Non-traceable author statement Ref.2. Source: UniProtKB cell cycle Non-traceable author statement Ref.2. Source: UniProtKB cell growth Non-traceable author statement Ref.2. Source: UniProtKB epidermal growth factor receptor signaling pathway Traceable author statement Ref.2. Source: UniProtKB establishment or maintenance of epithelial cell apical/basal polarity Non-traceable author statement Ref.2. Source: UniProtKB integrin-mediated signaling pathway Non-traceable author statement Ref.2. Source: UniProtKB intermediate filament cytoskeleton organization Non-traceable author statement Ref.2. Source: UniProtKB protein targeting Inferred from electronic annotation. Source: Compara
Cellular_component	basal plasma membrane Non-traceable author statement Ref.2. Source: UniProtKB basement membrane Traceable author statement Ref.1. Source: ProtInc cytoplasm Inferred from direct assay Ref.2. Source: UniProtKB hemidesmosome Inferred from direct assay Ref.2. Source: UniProtKB nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay Ref.2. Source: UniProtKB
Molecular_function	ErbB-2 class receptor binding Traceable author statement Ref.2. Source: UniProtKB structural constituent of cytoskeleton Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96RT1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96RT1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.

Isoform 3 (identifier: Q96RT1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1268-1278: Missing.

Isoform 4 (identifier: Q96RT1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1353-1377: Missing.

Isoform 5 (identifier: Q96RT1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1253-1267: Missing.

Isoform 6 (identifier: Q96RT1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1322-1352: Missing.

Isoform 7 (identifier: Q96RT1-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1253-1267: Missing.
     1268-1278: Missing.
     1279-1321: Missing.

Isoform 8 (identifier: Q96RT1-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: KHPQTSSSGD...KDVPPDSLMK → SMLSRSFNSN...RRGSGGHIFR

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1412

1412

Protein LAP2

PRO_0000188301

Regions

Repeat

23 – 44

22

LRR 1

Repeat

47 – 68

22

LRR 2

Repeat

70 – 91

22

LRR 3

Repeat

93 – 114

22

LRR 4

Repeat

116 – 137

22

LRR 5

Repeat

139 – 161

23

LRR 6

Repeat

162 – 183

22

LRR 7

Repeat

185 – 206

22

LRR 8

Repeat

208 – 229

22

LRR 9

Repeat

231 – 252

22

LRR 10

Repeat

254 – 275

22

LRR 11

Repeat

277 – 298

22

LRR 12

Repeat

300 – 321

22

LRR 13

Repeat

323 – 344

22

LRR 14

Repeat

346 – 367

22

LRR 15

Repeat

369 – 391

23

LRR 16

Repeat

392 – 413

22

LRR 17

Domain

1321 – 1410

90

PDZ

Compositional bias

930 – 934

5

Poly-Ser

Amino acid modifications

Modified residue

440

1

Phosphoserine Ref.11

Modified residue

569

1

Phosphoserine Ref.13 Ref.15

Modified residue

598

1

Phosphoserine By similarity

Modified residue

602

1

Phosphoserine Ref.15

Modified residue

603

1

Phosphoserine Ref.15

Modified residue

715

1

Phosphoserine By similarity

Modified residue

853

1

Phosphothreonine By similarity

Modified residue

857

1

Phosphoserine Ref.13

Modified residue

872

1

Phosphoserine Ref.14

Modified residue

917

1

Phosphothreonine Ref.13 Ref.14

Modified residue

920

1

Phosphotyrosine Ref.9

Modified residue

931

1

Phosphoserine Ref.14

Modified residue

972

1

Phosphotyrosine Ref.10

Modified residue

1104

1

Phosphotyrosine By similarity

Modified residue

1158

1

Phosphoserine Ref.14

Modified residue

1179

1

Phosphoserine By similarity

Modified residue

1286

1

Phosphoserine Ref.13

Natural variations

Alternative sequence

1212 – 1252

41

Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7.

VSP_010802

Alternative sequence

1212 – 1252

41

KHPQT…DSLMK → SMLSRSFNSNFTTVSSFHCG SSRDLHGSQGSLALSVADRR GSGGHIFR in isoform 8.

VSP_044536

Alternative sequence

1253 – 1267

15

Missing in isoform 5 and isoform 7.

VSP_010803

Alternative sequence

1268 – 1278

11

Missing in isoform 3 and isoform 7.

VSP_010804

Alternative sequence

1279 – 1321

43

Missing in isoform 7.

VSP_010805

Alternative sequence

1322 – 1352

31

Missing in isoform 6.

VSP_010806

Alternative sequence

1353 – 1377

25

Missing in isoform 4.

VSP_010807

Natural variant

274

1

S → L. Ref.7
Corresponds to variant rs3213837 [ dbSNP | Ensembl ].

VAR_019346

Natural variant

313

1

A → V. Ref.7
Corresponds to variant rs191137999 [ dbSNP | Ensembl ].

VAR_068905

Natural variant

746

1

K → E.
Corresponds to variant rs16894812 [ dbSNP | Ensembl ].

VAR_028304

Natural variant

914

1

K → R.
Corresponds to variant rs34521887 [ dbSNP | Ensembl ].

VAR_046673

Natural variant

1089

1

G → V.
Corresponds to variant rs35601230 [ dbSNP | Ensembl ].

VAR_046674

Natural variant

1112

1

S → L.
Corresponds to variant rs3805466 [ dbSNP | Ensembl ].

VAR_019347

Natural variant

1207

1

K → E. Ref.2

VAR_019348

Experimental info

Sequence conflict

271

1

T → P in AAI15013. Ref.7

Sequence conflict

531 – 534

4

Missing in AAH50692. Ref.7

Sequence conflict

547

1

D → G in AAI15013. Ref.7

Sequence conflict

805

1

E → G in BAA91538. Ref.5

Sequence conflict

813

1

Y → C in AAK69431. Ref.2

Sequence conflict

848

1

G → C in BAG65463. Ref.5

Sequence conflict

1047

1

R → S in BAG65463. Ref.5

Sequence conflict

1205

1

E → G in AAI15013. Ref.7

Sequence conflict

1267

1

Q → P in AAI15013. Ref.7

Sequence conflict

1328

1

K → R in AAI15013. Ref.7

Secondary structure

1

.

.

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.

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.

.

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.

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.

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1412

Helix Strand Turn

Details...

Beta strand

1318 – 1327

10

Beta strand

1329 – 1331

3

Beta strand

1333 – 1338

6

Turn

1339 – 1342

4

Beta strand

1346 – 1348

3

Beta strand

1353 – 1359

7

Turn

1364 – 1368

5

Beta strand

1374 – 1378

5

Helix

1388 – 1397

10

Beta strand

1400 – 1410

11

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 304DFC81578CF671	FASTA	1,412	158,298
	10 20 30 40 50 60 MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE 70 80 90 100 110 120 LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLTIV 130 140 150 160 170 180 EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM 190 200 210 220 230 240 NRLTQLERLD LGSNEFTEVP EVLEQLSGLK EFWMDANRLT FIPGFIGSLK QLTYLDVSKN 250 260 270 280 290 300 NIEMVEEGIS TCENLQDLLL SSNSLQQLPE TIGSLKNITT LKIDENQLMY LPDSIGGLIS 310 320 330 340 350 360 VEELDCSFNE VEALPSSIGQ LTNLRTFAAD HNYLQQLPPE IGSWKNITVL FLHSNKLETL 370 380 390 400 410 420 PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD NQSKPLIPLQ KETDSETQKM 430 440 450 460 470 480 VLTNYMFPQQ PRTEDVMFIS DNESFNPSLW EEQRKQRAQV AFECDEDKDE REAPPREGNL 490 500 510 520 530 540 KRYPTPYPDE LKNMVKTVQT IVHRLKDEET NEDSGRDLKP HEDQQDINKD VGVKTSESTT 550 560 570 580 590 600 TVKSKVDERE KYMIGNSVQK ISEPEAEISP GSLPVTANMK ASENLKHIVN HDDVFEESEE 610 620 630 640 650 660 LSSDEEMKMA EMRPPLIETS INQPKVVALS NNKKDDTKET DSLSDEVTHN SNQNNSNCSS 670 680 690 700 710 720 PSRMSDSVSL NTDSSQDTSL CSPVKQTHID INSKIRQEDE NFNSLLQNGD ILNSSTEEKF 730 740 750 760 770 780 KAHDKKDFNL PEYDLNVEER LVLIEKSVDS TATADDTHKL DHINMNLNKL ITNDTFQPEI 790 800 810 820 830 840 MERSKTQDIV LGTSFLSINS KEETEHLENG NKYPNLESVN KVNGHSEETS QSPNRTEPHD 850 860 870 880 890 900 SDCSVDLGIS KSTEDLSPQK SGPVGSVVKS HSITNMEIGG LKIYDILSDN GPQQPSTTVK 910 920 930 940 950 960 ITSAVDGKNI VRSKSATLLY DQPLQVFTGS SSSSDLISGT KAIFKFDSNH NPEEPNIIRG 970 980 990 1000 1010 1020 PTSGPQSAPQ IYGPPQYNIQ YSSSAAVKDT LWHSKQNPQI DHASFPPQLL PRSESTENQS 1030 1040 1050 1060 1070 1080 YAKHSANMNF SNHNNVRANT AYHLHQRLGP ARHGEMWAIS PNDRLIPAVT RSTIQRQSSV 1090 1100 1110 1120 1130 1140 SSTASVNLGD PGSTRRAQIP EGDYLSYREF HSAGRTPPMM PGSQRPLSAR TYSIDGPNAS 1150 1160 1170 1180 1190 1200 RPQSARPSIN EIPERTMSVS DFNYSRTSPS KRPNARVGSE HSLLDPPGKS KVPRDWREQV 1210 1220 1230 1240 1250 1260 LRHIEAKKLE KKHPQTSSSG DPCQDGIFIS GQQNYSSATL SHKDVPPDSL MKMPLSNGQM 1270 1280 1290 1300 1310 1320 GQPLRPQANY SQIHHPPQAS VARHPSREQL IDYLMLKVAH QPPYTQPHCS PRQGHELAKQ 1330 1340 1350 1360 1370 1380 EIRVRVEKDP ELGFSISGGV GGRGNPFRPD DDGIFVTRVQ PEGPASKLLQ PGDKIIQANG 1390 1400 1410 YSFINIEHGQ AVSLLKTFQN TVELIIVREV SS
	Isoform 2 [UniParc]. Checksum: C8F24683B0C4324D	FASTA	1,371	153,926
	10 20 30 40 50 60 MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE 70 80 90 100 110 120 LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLTIV 130 140 150 160 170 180 EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM 190 200 210 220 230 240 NRLTQLERLD LGSNEFTEVP EVLEQLSGLK EFWMDANRLT FIPGFIGSLK QLTYLDVSKN 250 260 270 280 290 300 NIEMVEEGIS TCENLQDLLL SSNSLQQLPE TIGSLKNITT LKIDENQLMY LPDSIGGLIS 310 320 330 340 350 360 VEELDCSFNE VEALPSSIGQ LTNLRTFAAD HNYLQQLPPE IGSWKNITVL FLHSNKLETL 370 380 390 400 410 420 PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD NQSKPLIPLQ KETDSETQKM 430 440 450 460 470 480 VLTNYMFPQQ PRTEDVMFIS DNESFNPSLW EEQRKQRAQV AFECDEDKDE REAPPREGNL 490 500 510 520 530 540 KRYPTPYPDE LKNMVKTVQT IVHRLKDEET NEDSGRDLKP HEDQQDINKD VGVKTSESTT 550 560 570 580 590 600 TVKSKVDERE KYMIGNSVQK ISEPEAEISP GSLPVTANMK ASENLKHIVN HDDVFEESEE 610 620 630 640 650 660 LSSDEEMKMA EMRPPLIETS INQPKVVALS NNKKDDTKET DSLSDEVTHN SNQNNSNCSS 670 680 690 700 710 720 PSRMSDSVSL NTDSSQDTSL CSPVKQTHID INSKIRQEDE NFNSLLQNGD ILNSSTEEKF 730 740 750 760 770 780 KAHDKKDFNL PEYDLNVEER LVLIEKSVDS TATADDTHKL DHINMNLNKL ITNDTFQPEI 790 800 810 820 830 840 MERSKTQDIV LGTSFLSINS KEETEHLENG NKYPNLESVN KVNGHSEETS QSPNRTEPHD 850 860 870 880 890 900 SDCSVDLGIS KSTEDLSPQK SGPVGSVVKS HSITNMEIGG LKIYDILSDN GPQQPSTTVK 910 920 930 940 950 960 ITSAVDGKNI VRSKSATLLY DQPLQVFTGS SSSSDLISGT KAIFKFDSNH NPEEPNIIRG 970 980 990 1000 1010 1020 PTSGPQSAPQ IYGPPQYNIQ YSSSAAVKDT LWHSKQNPQI DHASFPPQLL PRSESTENQS 1030 1040 1050 1060 1070 1080 YAKHSANMNF SNHNNVRANT AYHLHQRLGP ARHGEMWAIS PNDRLIPAVT RSTIQRQSSV 1090 1100 1110 1120 1130 1140 SSTASVNLGD PGSTRRAQIP EGDYLSYREF HSAGRTPPMM PGSQRPLSAR TYSIDGPNAS 1150 1160 1170 1180 1190 1200 RPQSARPSIN EIPERTMSVS DFNYSRTSPS KRPNARVGSE HSLLDPPGKS KVPRDWREQV 1210 1220 1230 1240 1250 1260 LRHIEAKKLE KMPLSNGQMG QPLRPQANYS QIHHPPQASV ARHPSREQLI DYLMLKVAHQ 1270 1280 1290 1300 1310 1320 PPYTQPHCSP RQGHELAKQE IRVRVEKDPE LGFSISGGVG GRGNPFRPDD DGIFVTRVQP 1330 1340 1350 1360 1370 EGPASKLLQP GDKIIQANGY SFINIEHGQA VSLLKTFQNT VELIIVREVS S
	Isoform 3 [UniParc]. Checksum: A56B9384680DA710	FASTA	1,360	152,653
	10 20 30 40 50 60 MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE 70 80 90 100 110 120 LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLTIV 130 140 150 160 170 180 EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM 190 200 210 220 230 240 NRLTQLERLD LGSNEFTEVP EVLEQLSGLK EFWMDANRLT FIPGFIGSLK QLTYLDVSKN 250 260 270 280 290 300 NIEMVEEGIS TCENLQDLLL SSNSLQQLPE TIGSLKNITT LKIDENQLMY LPDSIGGLIS 310 320 330 340 350 360 VEELDCSFNE VEALPSSIGQ LTNLRTFAAD HNYLQQLPPE IGSWKNITVL FLHSNKLETL 370 380 390 400 410 420 PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD NQSKPLIPLQ KETDSETQKM 430 440 450 460 470 480 VLTNYMFPQQ PRTEDVMFIS DNESFNPSLW EEQRKQRAQV AFECDEDKDE REAPPREGNL 490 500 510 520 530 540 KRYPTPYPDE LKNMVKTVQT IVHRLKDEET NEDSGRDLKP HEDQQDINKD VGVKTSESTT 550 560 570 580 590 600 TVKSKVDERE KYMIGNSVQK ISEPEAEISP GSLPVTANMK ASENLKHIVN HDDVFEESEE 610 620 630 640 650 660 LSSDEEMKMA EMRPPLIETS INQPKVVALS NNKKDDTKET DSLSDEVTHN SNQNNSNCSS 670 680 690 700 710 720 PSRMSDSVSL NTDSSQDTSL CSPVKQTHID INSKIRQEDE NFNSLLQNGD ILNSSTEEKF 730 740 750 760 770 780 KAHDKKDFNL PEYDLNVEER LVLIEKSVDS TATADDTHKL DHINMNLNKL ITNDTFQPEI 790 800 810 820 830 840 MERSKTQDIV LGTSFLSINS KEETEHLENG NKYPNLESVN KVNGHSEETS QSPNRTEPHD 850 860 870 880 890 900 SDCSVDLGIS KSTEDLSPQK SGPVGSVVKS HSITNMEIGG LKIYDILSDN GPQQPSTTVK 910 920 930 940 950 960 ITSAVDGKNI VRSKSATLLY DQPLQVFTGS SSSSDLISGT KAIFKFDSNH NPEEPNIIRG 970 980 990 1000 1010 1020 PTSGPQSAPQ IYGPPQYNIQ YSSSAAVKDT LWHSKQNPQI DHASFPPQLL PRSESTENQS 1030 1040 1050 1060 1070 1080 YAKHSANMNF SNHNNVRANT AYHLHQRLGP ARHGEMWAIS PNDRLIPAVT RSTIQRQSSV 1090 1100 1110 1120 1130 1140 SSTASVNLGD PGSTRRAQIP EGDYLSYREF HSAGRTPPMM PGSQRPLSAR TYSIDGPNAS 1150 1160 1170 1180 1190 1200 RPQSARPSIN EIPERTMSVS DFNYSRTSPS KRPNARVGSE HSLLDPPGKS KVPRDWREQV 1210 1220 1230 1240 1250 1260 LRHIEAKKLE KMPLSNGQMG QPLRPQASVA RHPSREQLID YLMLKVAHQP PYTQPHCSPR 1270 1280 1290 1300 1310 1320 QGHELAKQEI RVRVEKDPEL GFSISGGVGG RGNPFRPDDD GIFVTRVQPE GPASKLLQPG 1330 1340 1350 1360 DKIIQANGYS FINIEHGQAV SLLKTFQNTV ELIIVREVSS
	Isoform 4 [UniParc]. Checksum: 19D7B81B5A934C2E	FASTA	1,346	151,252
	10 20 30 40 50 60 MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE 70 80 90 100 110 120 LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLTIV 130 140 150 160 170 180 EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM 190 200 210 220 230 240 NRLTQLERLD LGSNEFTEVP EVLEQLSGLK EFWMDANRLT FIPGFIGSLK QLTYLDVSKN 250 260 270 280 290 300 NIEMVEEGIS TCENLQDLLL SSNSLQQLPE TIGSLKNITT LKIDENQLMY LPDSIGGLIS 310 320 330 340 350 360 VEELDCSFNE VEALPSSIGQ LTNLRTFAAD HNYLQQLPPE IGSWKNITVL FLHSNKLETL 370 380 390 400 410 420 PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD NQSKPLIPLQ KETDSETQKM 430 440 450 460 470 480 VLTNYMFPQQ PRTEDVMFIS DNESFNPSLW EEQRKQRAQV AFECDEDKDE REAPPREGNL 490 500 510 520 530 540 KRYPTPYPDE LKNMVKTVQT IVHRLKDEET NEDSGRDLKP HEDQQDINKD VGVKTSESTT 550 560 570 580 590 600 TVKSKVDERE KYMIGNSVQK ISEPEAEISP GSLPVTANMK ASENLKHIVN HDDVFEESEE 610 620 630 640 650 660 LSSDEEMKMA EMRPPLIETS INQPKVVALS NNKKDDTKET DSLSDEVTHN SNQNNSNCSS 670 680 690 700 710 720 PSRMSDSVSL NTDSSQDTSL CSPVKQTHID INSKIRQEDE NFNSLLQNGD ILNSSTEEKF 730 740 750 760 770 780 KAHDKKDFNL PEYDLNVEER LVLIEKSVDS TATADDTHKL DHINMNLNKL ITNDTFQPEI 790 800 810 820 830 840 MERSKTQDIV LGTSFLSINS KEETEHLENG NKYPNLESVN KVNGHSEETS QSPNRTEPHD 850 860 870 880 890 900 SDCSVDLGIS KSTEDLSPQK SGPVGSVVKS HSITNMEIGG LKIYDILSDN GPQQPSTTVK 910 920 930 940 950 960 ITSAVDGKNI VRSKSATLLY DQPLQVFTGS SSSSDLISGT KAIFKFDSNH NPEEPNIIRG 970 980 990 1000 1010 1020 PTSGPQSAPQ IYGPPQYNIQ YSSSAAVKDT LWHSKQNPQI DHASFPPQLL PRSESTENQS 1030 1040 1050 1060 1070 1080 YAKHSANMNF SNHNNVRANT AYHLHQRLGP ARHGEMWAIS PNDRLIPAVT RSTIQRQSSV 1090 1100 1110 1120 1130 1140 SSTASVNLGD PGSTRRAQIP EGDYLSYREF HSAGRTPPMM PGSQRPLSAR TYSIDGPNAS 1150 1160 1170 1180 1190 1200 RPQSARPSIN EIPERTMSVS DFNYSRTSPS KRPNARVGSE HSLLDPPGKS KVPRDWREQV 1210 1220 1230 1240 1250 1260 LRHIEAKKLE KMPLSNGQMG QPLRPQANYS QIHHPPQASV ARHPSREQLI DYLMLKVAHQ 1270 1280 1290 1300 1310 1320 PPYTQPHCSP RQGHELAKQE IRVRVEKDPE LGFSISGGVG GRGNPFRPDD DANGYSFINI 1330 1340 EHGQAVSLLK TFQNTVELII VREVSS
	Isoform 5 [UniParc]. Checksum: 9662C85F03C8F08B	FASTA	1,356	152,290
	10 20 30 40 50 60 MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE 70 80 90 100 110 120 LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLTIV 130 140 150 160 170 180 EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM 190 200 210 220 230 240 NRLTQLERLD LGSNEFTEVP EVLEQLSGLK EFWMDANRLT FIPGFIGSLK QLTYLDVSKN 250 260 270 280 290 300 NIEMVEEGIS TCENLQDLLL SSNSLQQLPE TIGSLKNITT LKIDENQLMY LPDSIGGLIS 310 320 330 340 350 360 VEELDCSFNE VEALPSSIGQ LTNLRTFAAD HNYLQQLPPE IGSWKNITVL FLHSNKLETL 370 380 390 400 410 420 PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD NQSKPLIPLQ KETDSETQKM 430 440 450 460 470 480 VLTNYMFPQQ PRTEDVMFIS DNESFNPSLW EEQRKQRAQV AFECDEDKDE REAPPREGNL 490 500 510 520 530 540 KRYPTPYPDE LKNMVKTVQT IVHRLKDEET NEDSGRDLKP HEDQQDINKD VGVKTSESTT 550 560 570 580 590 600 TVKSKVDERE KYMIGNSVQK ISEPEAEISP GSLPVTANMK ASENLKHIVN HDDVFEESEE 610 620 630 640 650 660 LSSDEEMKMA EMRPPLIETS INQPKVVALS NNKKDDTKET DSLSDEVTHN SNQNNSNCSS 670 680 690 700 710 720 PSRMSDSVSL NTDSSQDTSL CSPVKQTHID INSKIRQEDE NFNSLLQNGD ILNSSTEEKF 730 740 750 760 770 780 KAHDKKDFNL PEYDLNVEER LVLIEKSVDS TATADDTHKL DHINMNLNKL ITNDTFQPEI 790 800 810 820 830 840 MERSKTQDIV LGTSFLSINS KEETEHLENG NKYPNLESVN KVNGHSEETS QSPNRTEPHD 850 860 870 880 890 900 SDCSVDLGIS KSTEDLSPQK SGPVGSVVKS HSITNMEIGG LKIYDILSDN GPQQPSTTVK 910 920 930 940 950 960 ITSAVDGKNI VRSKSATLLY DQPLQVFTGS SSSSDLISGT KAIFKFDSNH NPEEPNIIRG 970 980 990 1000 1010 1020 PTSGPQSAPQ IYGPPQYNIQ YSSSAAVKDT LWHSKQNPQI DHASFPPQLL PRSESTENQS 1030 1040 1050 1060 1070 1080 YAKHSANMNF SNHNNVRANT AYHLHQRLGP ARHGEMWAIS PNDRLIPAVT RSTIQRQSSV 1090 1100 1110 1120 1130 1140 SSTASVNLGD PGSTRRAQIP EGDYLSYREF HSAGRTPPMM PGSQRPLSAR TYSIDGPNAS 1150 1160 1170 1180 1190 1200 RPQSARPSIN EIPERTMSVS DFNYSRTSPS KRPNARVGSE HSLLDPPGKS KVPRDWREQV 1210 1220 1230 1240 1250 1260 LRHIEAKKLE KANYSQIHHP PQASVARHPS REQLIDYLML KVAHQPPYTQ PHCSPRQGHE 1270 1280 1290 1300 1310 1320 LAKQEIRVRV EKDPELGFSI SGGVGGRGNP FRPDDDGIFV TRVQPEGPAS KLLQPGDKII 1330 1340 1350 QANGYSFINI EHGQAVSLLK TFQNTVELII VREVSS
	Isoform 6 [UniParc]. Checksum: 12B24ADE16A5F537	FASTA	1,340	150,602
	10 20 30 40 50 60 MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE 70 80 90 100 110 120 LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLTIV 130 140 150 160 170 180 EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM 190 200 210 220 230 240 NRLTQLERLD LGSNEFTEVP EVLEQLSGLK EFWMDANRLT FIPGFIGSLK QLTYLDVSKN 250 260 270 280 290 300 NIEMVEEGIS TCENLQDLLL SSNSLQQLPE TIGSLKNITT LKIDENQLMY LPDSIGGLIS 310 320 330 340 350 360 VEELDCSFNE VEALPSSIGQ LTNLRTFAAD HNYLQQLPPE IGSWKNITVL FLHSNKLETL 370 380 390 400 410 420 PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD NQSKPLIPLQ KETDSETQKM 430 440 450 460 470 480 VLTNYMFPQQ PRTEDVMFIS DNESFNPSLW EEQRKQRAQV AFECDEDKDE REAPPREGNL 490 500 510 520 530 540 KRYPTPYPDE LKNMVKTVQT IVHRLKDEET NEDSGRDLKP HEDQQDINKD VGVKTSESTT 550 560 570 580 590 600 TVKSKVDERE KYMIGNSVQK ISEPEAEISP GSLPVTANMK ASENLKHIVN HDDVFEESEE 610 620 630 640 650 660 LSSDEEMKMA EMRPPLIETS INQPKVVALS NNKKDDTKET DSLSDEVTHN SNQNNSNCSS 670 680 690 700 710 720 PSRMSDSVSL NTDSSQDTSL CSPVKQTHID INSKIRQEDE NFNSLLQNGD ILNSSTEEKF 730 740 750 760 770 780 KAHDKKDFNL PEYDLNVEER LVLIEKSVDS TATADDTHKL DHINMNLNKL ITNDTFQPEI 790 800 810 820 830 840 MERSKTQDIV LGTSFLSINS KEETEHLENG NKYPNLESVN KVNGHSEETS QSPNRTEPHD 850 860 870 880 890 900 SDCSVDLGIS KSTEDLSPQK SGPVGSVVKS HSITNMEIGG LKIYDILSDN GPQQPSTTVK 910 920 930 940 950 960 ITSAVDGKNI VRSKSATLLY DQPLQVFTGS SSSSDLISGT KAIFKFDSNH NPEEPNIIRG 970 980 990 1000 1010 1020 PTSGPQSAPQ IYGPPQYNIQ YSSSAAVKDT LWHSKQNPQI DHASFPPQLL PRSESTENQS 1030 1040 1050 1060 1070 1080 YAKHSANMNF SNHNNVRANT AYHLHQRLGP ARHGEMWAIS PNDRLIPAVT RSTIQRQSSV 1090 1100 1110 1120 1130 1140 SSTASVNLGD PGSTRRAQIP EGDYLSYREF HSAGRTPPMM PGSQRPLSAR TYSIDGPNAS 1150 1160 1170 1180 1190 1200 RPQSARPSIN EIPERTMSVS DFNYSRTSPS KRPNARVGSE HSLLDPPGKS KVPRDWREQV 1210 1220 1230 1240 1250 1260 LRHIEAKKLE KMPLSNGQMG QPLRPQANYS QIHHPPQASV ARHPSREQLI DYLMLKVAHQ 1270 1280 1290 1300 1310 1320 PPYTQPHCSP RQGHELAKQE GIFVTRVQPE GPASKLLQPG DKIIQANGYS FINIEHGQAV 1330 1340 SLLKTFQNTV ELIIVREVSS
	Isoform 7 [UniParc]. Checksum: E436063ACDA2C1A4	FASTA	1,302	146,086
	10 20 30 40 50 60 MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE 70 80 90 100 110 120 LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLTIV 130 140 150 160 170 180 EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM 190 200 210 220 230 240 NRLTQLERLD LGSNEFTEVP EVLEQLSGLK EFWMDANRLT FIPGFIGSLK QLTYLDVSKN 250 260 270 280 290 300 NIEMVEEGIS TCENLQDLLL SSNSLQQLPE TIGSLKNITT LKIDENQLMY LPDSIGGLIS 310 320 330 340 350 360 VEELDCSFNE VEALPSSIGQ LTNLRTFAAD HNYLQQLPPE IGSWKNITVL FLHSNKLETL 370 380 390 400 410 420 PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD NQSKPLIPLQ KETDSETQKM 430 440 450 460 470 480 VLTNYMFPQQ PRTEDVMFIS DNESFNPSLW EEQRKQRAQV AFECDEDKDE REAPPREGNL 490 500 510 520 530 540 KRYPTPYPDE LKNMVKTVQT IVHRLKDEET NEDSGRDLKP HEDQQDINKD VGVKTSESTT 550 560 570 580 590 600 TVKSKVDERE KYMIGNSVQK ISEPEAEISP GSLPVTANMK ASENLKHIVN HDDVFEESEE 610 620 630 640 650 660 LSSDEEMKMA EMRPPLIETS INQPKVVALS NNKKDDTKET DSLSDEVTHN SNQNNSNCSS 670 680 690 700 710 720 PSRMSDSVSL NTDSSQDTSL CSPVKQTHID INSKIRQEDE NFNSLLQNGD ILNSSTEEKF 730 740 750 760 770 780 KAHDKKDFNL PEYDLNVEER LVLIEKSVDS TATADDTHKL DHINMNLNKL ITNDTFQPEI 790 800 810 820 830 840 MERSKTQDIV LGTSFLSINS KEETEHLENG NKYPNLESVN KVNGHSEETS QSPNRTEPHD 850 860 870 880 890 900 SDCSVDLGIS KSTEDLSPQK SGPVGSVVKS HSITNMEIGG LKIYDILSDN GPQQPSTTVK 910 920 930 940 950 960 ITSAVDGKNI VRSKSATLLY DQPLQVFTGS SSSSDLISGT KAIFKFDSNH NPEEPNIIRG 970 980 990 1000 1010 1020 PTSGPQSAPQ IYGPPQYNIQ YSSSAAVKDT LWHSKQNPQI DHASFPPQLL PRSESTENQS 1030 1040 1050 1060 1070 1080 YAKHSANMNF SNHNNVRANT AYHLHQRLGP ARHGEMWAIS PNDRLIPAVT RSTIQRQSSV 1090 1100 1110 1120 1130 1140 SSTASVNLGD PGSTRRAQIP EGDYLSYREF HSAGRTPPMM PGSQRPLSAR TYSIDGPNAS 1150 1160 1170 1180 1190 1200 RPQSARPSIN EIPERTMSVS DFNYSRTSPS KRPNARVGSE HSLLDPPGKS KVPRDWREQV 1210 1220 1230 1240 1250 1260 LRHIEAKKLE KIRVRVEKDP ELGFSISGGV GGRGNPFRPD DDGIFVTRVQ PEGPASKLLQ 1270 1280 1290 1300 PGDKIIQANG YSFINIEHGQ AVSLLKTFQN TVELIIVREV SS
	Isoform 8 [UniParc]. Checksum: 9E18163421DBE278	FASTA	1,419	159,024
	10 20 30 40 50 60 MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE 70 80 90 100 110 120 LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLTIV 130 140 150 160 170 180 EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM 190 200 210 220 230 240 NRLTQLERLD LGSNEFTEVP EVLEQLSGLK EFWMDANRLT FIPGFIGSLK QLTYLDVSKN 250 260 270 280 290 300 NIEMVEEGIS TCENLQDLLL SSNSLQQLPE TIGSLKNITT LKIDENQLMY LPDSIGGLIS 310 320 330 340 350 360 VEELDCSFNE VEALPSSIGQ LTNLRTFAAD HNYLQQLPPE IGSWKNITVL FLHSNKLETL 370 380 390 400 410 420 PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD NQSKPLIPLQ KETDSETQKM 430 440 450 460 470 480 VLTNYMFPQQ PRTEDVMFIS DNESFNPSLW EEQRKQRAQV AFECDEDKDE REAPPREGNL 490 500 510 520 530 540 KRYPTPYPDE LKNMVKTVQT IVHRLKDEET NEDSGRDLKP HEDQQDINKD VGVKTSESTT 550 560 570 580 590 600 TVKSKVDERE KYMIGNSVQK ISEPEAEISP GSLPVTANMK ASENLKHIVN HDDVFEESEE 610 620 630 640 650 660 LSSDEEMKMA EMRPPLIETS INQPKVVALS NNKKDDTKET DSLSDEVTHN SNQNNSNCSS 670 680 690 700 710 720 PSRMSDSVSL NTDSSQDTSL CSPVKQTHID INSKIRQEDE NFNSLLQNGD ILNSSTEEKF 730 740 750 760 770 780 KAHDKKDFNL PEYDLNVEER LVLIEKSVDS TATADDTHKL DHINMNLNKL ITNDTFQPEI 790 800 810 820 830 840 MERSKTQDIV LGTSFLSINS KEETEHLENG NKYPNLESVN KVNGHSEETS QSPNRTEPHD 850 860 870 880 890 900 SDCSVDLGIS KSTEDLSPQK SGPVGSVVKS HSITNMEIGG LKIYDILSDN GPQQPSTTVK 910 920 930 940 950 960 ITSAVDGKNI VRSKSATLLY DQPLQVFTGS SSSSDLISGT KAIFKFDSNH NPEEPNIIRG 970 980 990 1000 1010 1020 PTSGPQSAPQ IYGPPQYNIQ YSSSAAVKDT LWHSKQNPQI DHASFPPQLL PRSESTENQS 1030 1040 1050 1060 1070 1080 YAKHSANMNF SNHNNVRANT AYHLHQRLGP ARHGEMWAIS PNDRLIPAVT RSTIQRQSSV 1090 1100 1110 1120 1130 1140 SSTASVNLGD PGSTRRAQIP EGDYLSYREF HSAGRTPPMM PGSQRPLSAR TYSIDGPNAS 1150 1160 1170 1180 1190 1200 RPQSARPSIN EIPERTMSVS DFNYSRTSPS KRPNARVGSE HSLLDPPGKS KVPRDWREQV 1210 1220 1230 1240 1250 1260 LRHIEAKKLE KSMLSRSFNS NFTTVSSFHC GSSRDLHGSQ GSLALSVADR RGSGGHIFRM 1270 1280 1290 1300 1310 1320 PLSNGQMGQP LRPQANYSQI HHPPQASVAR HPSREQLIDY LMLKVAHQPP YTQPHCSPRQ 1330 1340 1350 1360 1370 1380 GHELAKQEIR VRVEKDPELG FSISGGVGGR GNPFRPDDDG IFVTRVQPEG PASKLLQPGD 1390 1400 1410 KIIQANGYSF INIEHGQAVS LLKTFQNTVE LIIVREVSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor." Borg J.-P., Marchetto S., Le Bivic A., Ollendorff V., Jaulin-Bastard F., Saito H., Fournier E., Adelaide J., Margolis B., Birnbaum D. Nat. Cell Biol. 2:407-414(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH ERBB2, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION. Tissue: B-cell.
[2]	"The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression." Favre B., Fontao L., Koster J., Shafaatian R., Jaunin F., Saurat J.-H., Sonnenberg A., Borradori L. J. Biol. Chem. 276:32427-32436(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6 AND 7), INTERACTION WITH BPAG1; DST AND ITGB4, SUBCELLULAR LOCATION, VARIANT GLU-1207.
[3]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 601-1206 (ISOFORM 1). Tissue: Teratocarcinoma and Uterus.
[6]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-634 (ISOFORM 1), VARIANTS LEU-274 AND VAL-313. Tissue: Cerebellum and Skin.
[8]	"The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF." Laura R.P., Witt A.S., Held H.A., Gerstner R., Deshayes K., Koehler M.F.T., Kosik K.S., Sidhu S.S., Lasky L.A. J. Biol. Chem. 277:12906-12914(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DELTA CATENIN AND ARVCF.
[9]	"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry." Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C. Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-920, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-972, MASS SPECTROMETRY.
[11]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-440, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Platelet.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-569; SER-857; THR-917 AND SER-1286, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-872; THR-917; SER-931 AND SER-1158, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[15]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-569; SER-602 AND SER-603, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]	"Novel mode of ligand recognition by the Erbin PDZ domain." Birrane G., Chung J., Ladias J.A. J. Biol. Chem. 278:1399-1402(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 1321-1412 IN COMPLEX WITH ERBB2 C-TERMINUS.
[18]	"Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain." Skelton N.J., Koehler M.F.T., Zobel K., Wong W.L., Yeh S., Pisabarro M.T., Yin J.P., Lasky L.A., Sidhu S.S. J. Biol. Chem. 278:7645-7654(2003) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 1314-1412 IN COMPLEX WITH PHAGE-DERIVED PEPTIDE.
[19]	"Comparative structural analysis of the erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity." Appleton B.A., Zhang Y., Wu P., Yin J.P., Hunziker W., Skelton N.J., Sidhu S.S., Wiesmann C. J. Biol. Chem. 281:22312-22320(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.0 ANGSTROMS) OF 1314-1412.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF263744 mRNA. Translation: AAF77048.1.
AF276423 mRNA. Translation: AAK69431.1.
AB033051 mRNA. Translation: BAA86539.2.
AK001180 mRNA. Translation: BAA91538.1. Different initiation.
AK304693 mRNA. Translation: BAG65463.1.
AC010359 Genomic DNA. No translation available.
AC025442 Genomic DNA. No translation available.
BC050692 mRNA. Translation: AAH50692.1. Sequence problems.
BC115012 mRNA. Translation: AAI15013.1.
BC126464 mRNA. Translation: AAI26465.1.
BC144075 mRNA. Translation: AAI44076.1.

IPI

IPI00438286.
IPI00438287.
IPI00438288.
IPI00438289.
IPI00438290.
IPI00438291.
IPI00438292.

RefSeq

NP_001006600.1. NM_001006600.2.
NP_001240626.1. NM_001253697.1.
NP_001240627.1. NM_001253698.1.
NP_001240628.1. NM_001253699.1.
NP_001240630.1. NM_001253701.1.
NP_061165.1. NM_018695.3.

UniGene

Hs.597241.
Hs.731734.
Hs.740465.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1MFG	X-ray	1.25	A	1321-1412	[»]
1MFL	X-ray	1.88	A	1321-1412	[»]
1N7T	NMR	-	A	1314-1412	[»]
2H3L	X-ray	1.00	A/B	1314-1412	[»]
2QBW	X-ray	1.80	A	1318-1410	[»]
3CH8	X-ray	1.90	A	1318-1410	[»]

ProteinModelPortal

Q96RT1.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q96RT1. 9 interactions.

MINT

MINT-199447.

STRING

9606.ENSP00000370330.

PTM databases

PhosphoSite

Q96RT1.

Polymorphism databases

DMDM

116242614.

Proteomic databases

PaxDb

Q96RT1.

PRIDE

Q96RT1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000284037; ENSP00000284037; ENSG00000112851.
ENST00000380935; ENSP00000370322; ENSG00000112851.
ENST00000380936; ENSP00000370323; ENSG00000112851.
ENST00000380938; ENSP00000370325; ENSG00000112851.
ENST00000380939; ENSP00000370326; ENSG00000112851.
ENST00000380943; ENSP00000370330; ENSG00000112851.
ENST00000506030; ENSP00000426632; ENSG00000112851.
ENST00000508515; ENSP00000422015; ENSG00000112851.

GeneID

55914.

KEGG

hsa:55914.

UCSC

uc003jui.2. human.
uc003juj.2. human.
uc003juk.2. human.
uc011cqy.2. human.

Organism-specific databases

CTD

55914.

GeneCards

GC05P065258.

HGNC

HGNC:15842. ERBB2IP.

HPA

HPA048606.

MIM

606944. gene.

neXtProt

NX_Q96RT1.

PharmGKB

PA27845.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG4886.

HOGENOM

HOG000060229.

HOVERGEN

HBG052305.

InParanoid

Q96RT1.

KO

K12796.

OMA

HNNVRAN.

OrthoDB

EOG41JZBG.

PhylomeDB

Q96RT1.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

Q96RT1.

Bgee

Q96RT1.

CleanEx

HS_ERBB2IP.

Genevestigator

Q96RT1.

GermOnline

ENSG00000112851. Homo sapiens.

Family and domain databases

InterPro

IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR001478. PDZ.
[Graphical view]

Pfam

PF12799. LRR_4. 2 hits.
PF00595. PDZ. 1 hit.
[Graphical view]

SMART

SM00228. PDZ. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 1 hit.

PROSITE

PS51450. LRR. 15 hits.
PS50106. PDZ. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

ERBB2IP. human.

EvolutionaryTrace

Q96RT1.

GenomeRNAi

55914.

NextBio

61305.

SOURCE

Search...

Entry information

Entry name

LAP2_HUMAN

Accession

Primary (citable) accession number: Q96RT1
Secondary accession number(s): A0AVR1 , B4E3F1, B7ZLV9, E9PCR8, Q1RMD0, Q86W38, Q9NR18, Q9NW48, Q9ULJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.