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Q96RR4

- KKCC2_HUMAN

UniProt

Q96RR4 - KKCC2_HUMAN

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Protein

Calcium/calmodulin-dependent protein kinase kinase 2

Gene

CAMKK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca2+ signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.By similarity4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by Ca2+/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca2+/calmodulin. In part, activity is independent on Ca2+/calmodulin (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei194 – 1941ATPPROSITE-ProRule annotation
Active sitei312 – 3121Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi171 – 1799ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium ion binding Source: UniProtKB
  3. calmodulin binding Source: UniProtKB
  4. calmodulin-dependent protein kinase activity Source: UniProtKB-EC
  5. protein tyrosine kinase activity Source: UniProtKB

GO - Biological processi

  1. calcium-mediated signaling Source: UniProtKB
  2. MAPK cascade Source: UniProtKB
  3. peptidyl-tyrosine phosphorylation Source: GOC
  4. positive regulation of transcription, DNA-templated Source: UniProtKB
  5. protein autophosphorylation Source: UniProtKB
  6. protein phosphorylation Source: UniProtKB
  7. regulation of protein kinase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96RR4.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase kinase 2 (EC:2.7.11.17)
Short name:
CaM-KK 2
Short name:
CaM-kinase kinase 2
Short name:
CaMKK 2
Alternative name(s):
Calcium/calmodulin-dependent protein kinase kinase beta
Short name:
CaM-KK beta
Short name:
CaM-kinase kinase beta
Short name:
CaMKK beta
Gene namesi
Name:CAMKK2
Synonyms:CAMKKB, KIAA0787
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:1470. CAMKK2.

Subcellular locationi

Nucleus By similarity. Cytoplasm 1 Publication. Cell projection 1 Publication
Note: Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction.By similarity

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. cytoplasm Source: HPA
  3. intracellular Source: UniProtKB
  4. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26052.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 588587Calcium/calmodulin-dependent protein kinase kinase 2PRO_0000086144Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei129 – 1291PhosphoserineBy similarity
Modified residuei133 – 1331PhosphoserineBy similarity
Modified residuei495 – 4951Phosphoserine1 Publication

Post-translational modificationi

Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96RR4.
PaxDbiQ96RR4.
PRIDEiQ96RR4.

PTM databases

PhosphoSiteiQ96RR4.

Expressioni

Tissue specificityi

Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.1 Publication

Inductioni

Isoform 1 is up-regulated by PKA pathway.1 Publication

Gene expression databases

BgeeiQ96RR4.
CleanExiHS_CAMKK2.
ExpressionAtlasiQ96RR4. baseline and differential.
GenevestigatoriQ96RR4.

Organism-specific databases

HPAiHPA017389.

Interactioni

Subunit structurei

Interacts with calmodulin.By similarity

Protein-protein interaction databases

BioGridi115889. 26 interactions.
IntActiQ96RR4. 19 interactions.

Structurei

Secondary structure

1
588
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi165 – 1728
Beta strandi178 – 1847
Turni185 – 1884
Beta strandi189 – 1979
Helixi232 – 24110
Beta strandi251 – 2566
Beta strandi258 – 26811
Helixi286 – 30520
Helixi315 – 3173
Beta strandi318 – 3203
Beta strandi326 – 3283
Beta strandi338 – 3414
Helixi351 – 3533
Helixi356 – 3583
Beta strandi366 – 3683
Helixi369 – 38517
Helixi395 – 40410
Beta strandi411 – 4133
Helixi417 – 42610
Turni431 – 4333
Helixi437 – 4404
Helixi444 – 4474

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZV2X-ray2.40A158-448[»]
ProteinModelPortaliQ96RR4.
SMRiQ96RR4. Positions 80-484.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96RR4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 446282Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni204 – 22623RP domainAdd
BLAST
Regioni472 – 4776Autoinhibitory domainBy similarity
Regioni475 – 50026Calmodulin-bindingBy similarityAdd
BLAST

Domaini

The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.By similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00530000063214.
HOVERGENiHBG052262.
InParanoidiQ96RR4.
KOiK07359.
OMAiMNGRCIC.
OrthoDBiEOG7F5114.
PhylomeDBiQ96RR4.
TreeFamiTF313013.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96RR4-1) [UniParc]FASTAAdd to Basket

Also known as: Beta1, CAMKK2+E16

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME
60 70 80 90 100
SFIVVTECEP GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS
110 120 130 140 150
LQERSQGGLA AGGSLDMNGR CICPSLPYSP VSSPQSSPRL PRRPTVESHH
160 170 180 190 200
VSITGMQDCV QLNQYTLKDE IGKGSYGVVK LAYNENDNTY YAMKVLSKKK
210 220 230 240 250
LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL KKLDHPNVVK
260 270 280 290 300
LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI
310 320 330 340 350
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT
360 370 380 390 400
PAFMAPESLS ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS
410 420 430 440 450
KIKSQALEFP DQPDIAEDLK DLITRMLDKN PESRIVVPEI KLHPWVTRHG
460 470 480 490 500
AEPLPSEDEN CTLVEVTEEE VENSVKHIPS LATVILVKTM IRKRSFGNPF
510 520 530 540 550
EGSRREERSL SAPGNLLTKK PTRECESLSE LKEARQRRQP PGHRPAPRGG
560 570 580
GGSALVRGSP CVESCWAPAP GSPARMHPLR PEEAMEPE

Note: Major isoform.

Length:588
Mass (Da):64,746
Last modified:January 11, 2011 - v2
Checksum:i04E3583561341167
GO
Isoform 2 (identifier: Q96RR4-2) [UniParc]FASTAAdd to Basket

Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
     533-533: E → T
     534-554: Missing.
     555-588: Missing.

Note: Major isoform.

Show »
Length:533
Mass (Da):58,899
Checksum:i98FAAB0FB8C4CACF
GO
Isoform 3 (identifier: Q96RR4-3) [UniParc]FASTAAdd to Basket

Also known as: Beta1delta16, CAMKK2-E16

The sequence of this isoform differs from the canonical sequence as follows:
     520-532: KPTRECESLSELK → QGSEDNLQGTDPP
     533-541: EARQRRQPP → PVGEEEVLL
     542-554: Missing.
     555-588: Missing.

Note: Contains a phosphoserine at position 522.

Show »
Length:541
Mass (Da):59,602
Checksum:iD9A56C3D780C0DDE
GO
Isoform 4 (identifier: Q96RR4-4) [UniParc]FASTAAdd to Basket

Also known as: Beta1delta14

The sequence of this isoform differs from the canonical sequence as follows:
     442-484: Missing.

Show »
Length:545
Mass (Da):59,971
Checksum:iEE849E31E0416BC3
GO
Isoform 5 (identifier: Q96RR4-5) [UniParc]FASTAAdd to Basket

Also known as: Beta1delta14/16, beta-3x

The sequence of this isoform differs from the canonical sequence as follows:
     442-484: Missing.
     520-532: KPTRECESLSELK → QGSEDNLQGTDPP
     533-541: EARQRRQPP → PVGEEEVLL
     542-554: Missing.
     555-588: Missing.

Note: Inactive. Does not activate CAMK1 and CAMK4. Contains a phosphoserine at position 479.

Show »
Length:498
Mass (Da):54,827
Checksum:i6D051947DDCB69E1
GO
Isoform 6 (identifier: Q96RR4-6) [UniParc]FASTAAdd to Basket

Also known as: Beta2delta14

The sequence of this isoform differs from the canonical sequence as follows:
     442-484: Missing.
     533-533: E → T
     534-554: Missing.
     555-588: Missing.

Note: Inactive. Does not activate CAMK1 and CAMK4.

Show »
Length:490
Mass (Da):54,124
Checksum:i0821956F65E543C4
GO
Isoform 7 (identifier: Q96RR4-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     533-554: EARQRRQPPGHRPAPRGGGGSA → GTKKKKGLDSMTSTVAAGWLDRRV
     555-588: Missing.

Show »
Length:556
Mass (Da):61,386
Checksum:i47E33706CE77489C
GO

Sequence cautioni

The sequence CAD38990.1 differs from that shown. Reason: Intron retention.
The sequence AAC72943.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA34507.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti206 – 2061G → A in AAD31507. (PubMed:9822657)Curated
Sequence conflicti331 – 3311F → I in BAF84761. (PubMed:14702039)Curated
Sequence conflicti347 – 3471T → Y in AAD31507. (PubMed:9822657)Curated
Sequence conflicti371 – 3711L → K in AAD31507. (PubMed:9822657)Curated
Sequence conflicti554 – 5541A → H in AAK91829. (PubMed:11395482)Curated
Sequence conflicti557 – 5571R → N in AAK91829. (PubMed:11395482)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101S → N.1 Publication
Corresponds to variant rs28360477 [ dbSNP | Ensembl ].
VAR_032788
Natural varianti85 – 851T → S.4 Publications
Corresponds to variant rs3817190 [ dbSNP | Ensembl ].
VAR_020532
Natural varianti123 – 1231C → Y.1 Publication
Corresponds to variant rs35403710 [ dbSNP | Ensembl ].
VAR_040610
Natural varianti127 – 1271P → L in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication
VAR_040611
Natural varianti182 – 1821A → T in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040612
Natural varianti363 – 3631R → C.
Corresponds to variant rs1132780 [ dbSNP | Ensembl ].
VAR_020533
Natural varianti492 – 4921R → H.1 Publication
Corresponds to variant rs34129994 [ dbSNP | Ensembl ].
VAR_040613

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei442 – 48443Missing in isoform 4, isoform 5 and isoform 6. 2 PublicationsVSP_012142Add
BLAST
Alternative sequencei520 – 53213KPTRE…LSELK → QGSEDNLQGTDPP in isoform 3 and isoform 5. 4 PublicationsVSP_012143Add
BLAST
Alternative sequencei533 – 55422EARQR…GGGSA → GTKKKKGLDSMTSTVAAGWL DRRV in isoform 7. 2 PublicationsVSP_012148Add
BLAST
Alternative sequencei533 – 5419EARQRRQPP → PVGEEEVLL in isoform 3 and isoform 5. 4 PublicationsVSP_012144
Alternative sequencei533 – 5331E → T in isoform 2 and isoform 6. 3 PublicationsVSP_012146
Alternative sequencei534 – 55421Missing in isoform 2 and isoform 6. 3 PublicationsVSP_012147Add
BLAST
Alternative sequencei542 – 55413Missing in isoform 3 and isoform 5. 4 PublicationsVSP_012145Add
BLAST
Alternative sequencei555 – 58834Missing in isoform 2, isoform 3, isoform 5, isoform 6 and isoform 7. 8 PublicationsVSP_012149Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB081337 mRNA. Translation: BAC19841.1.
AF287630 mRNA. Translation: AAK64600.1.
AF287631 mRNA. Translation: AAK64601.1.
AF321385 mRNA. Translation: AAL37215.1.
AF321386 mRNA. Translation: AAL37216.1.
AF321387 mRNA. Translation: AAL37217.1.
AF321388 mRNA. Translation: AAL37218.1.
AF321401
, AF321390, AF321391, AF321392, AF321393, AF321394, AF321395, AF321396, AF321397, AF321398, AF321399, AF321400, AF321575, AF321576, AF321577, AF321578 Genomic DNA. Translation: AAK91830.1.
AF321402
, AF321390, AF321391, AF321392, AF321393, AF321394, AF321395, AF321396, AF321397, AF321398, AF321399, AF321400, AF321575, AF321576, AF321577, AF321578 Genomic DNA. Translation: AAK91829.1.
AF140507 mRNA. Translation: AAD31507.1.
AB081336 mRNA. Translation: BAC19840.1.
AB018330 mRNA. Translation: BAA34507.2. Different initiation.
AK292072 mRNA. Translation: BAF84761.1.
AC069209 Genomic DNA. No translation available.
BC000318 mRNA. Translation: AAH00318.2.
BC026060 mRNA. Translation: AAH26060.1.
AF101264 mRNA. Translation: AAD04566.1.
AL834322 mRNA. Translation: CAD38990.1. Sequence problems.
AF091074 mRNA. Translation: AAC72943.1. Different initiation.
CCDSiCCDS44999.1. [Q96RR4-2]
CCDS53837.1. [Q96RR4-6]
CCDS58283.1. [Q96RR4-7]
CCDS9216.1. [Q96RR4-1]
CCDS9217.1. [Q96RR4-4]
CCDS9218.1. [Q96RR4-3]
CCDS9219.1. [Q96RR4-5]
PIRiJE0191.
RefSeqiNP_001257414.1. NM_001270485.1. [Q96RR4-1]
NP_001257415.1. NM_001270486.1. [Q96RR4-7]
NP_006540.3. NM_006549.3. [Q96RR4-1]
NP_705719.2. NM_153499.2. [Q96RR4-3]
NP_705720.1. NM_153500.1. [Q96RR4-5]
NP_757363.1. NM_172214.2. [Q96RR4-2]
NP_757364.1. NM_172215.2. [Q96RR4-6]
NP_757365.1. NM_172216.1. [Q96RR4-4]
NP_757380.1. NM_172226.2. [Q96RR4-3]
XP_005253880.1. XM_005253823.1. [Q96RR4-2]
XP_005253881.1. XM_005253824.2. [Q96RR4-5]
UniGeneiHs.297343.

Genome annotation databases

GeneIDi10645.
KEGGihsa:10645.
UCSCiuc001tzt.3. human. [Q96RR4-3]
uc001tzu.3. human. [Q96RR4-1]
uc001tzw.3. human. [Q96RR4-4]
uc001tzy.3. human. [Q96RR4-5]
uc001uaa.2. human. [Q96RR4-7]
uc001uab.3. human. [Q96RR4-2]
uc001uac.3. human. [Q96RR4-6]

Polymorphism databases

DMDMi317373374.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB081337 mRNA. Translation: BAC19841.1 .
AF287630 mRNA. Translation: AAK64600.1 .
AF287631 mRNA. Translation: AAK64601.1 .
AF321385 mRNA. Translation: AAL37215.1 .
AF321386 mRNA. Translation: AAL37216.1 .
AF321387 mRNA. Translation: AAL37217.1 .
AF321388 mRNA. Translation: AAL37218.1 .
AF321401
, AF321390 , AF321391 , AF321392 , AF321393 , AF321394 , AF321395 , AF321396 , AF321397 , AF321398 , AF321399 , AF321400 , AF321575 , AF321576 , AF321577 , AF321578 Genomic DNA. Translation: AAK91830.1 .
AF321402
, AF321390 , AF321391 , AF321392 , AF321393 , AF321394 , AF321395 , AF321396 , AF321397 , AF321398 , AF321399 , AF321400 , AF321575 , AF321576 , AF321577 , AF321578 Genomic DNA. Translation: AAK91829.1 .
AF140507 mRNA. Translation: AAD31507.1 .
AB081336 mRNA. Translation: BAC19840.1 .
AB018330 mRNA. Translation: BAA34507.2 . Different initiation.
AK292072 mRNA. Translation: BAF84761.1 .
AC069209 Genomic DNA. No translation available.
BC000318 mRNA. Translation: AAH00318.2 .
BC026060 mRNA. Translation: AAH26060.1 .
AF101264 mRNA. Translation: AAD04566.1 .
AL834322 mRNA. Translation: CAD38990.1 . Sequence problems.
AF091074 mRNA. Translation: AAC72943.1 . Different initiation.
CCDSi CCDS44999.1. [Q96RR4-2 ]
CCDS53837.1. [Q96RR4-6 ]
CCDS58283.1. [Q96RR4-7 ]
CCDS9216.1. [Q96RR4-1 ]
CCDS9217.1. [Q96RR4-4 ]
CCDS9218.1. [Q96RR4-3 ]
CCDS9219.1. [Q96RR4-5 ]
PIRi JE0191.
RefSeqi NP_001257414.1. NM_001270485.1. [Q96RR4-1 ]
NP_001257415.1. NM_001270486.1. [Q96RR4-7 ]
NP_006540.3. NM_006549.3. [Q96RR4-1 ]
NP_705719.2. NM_153499.2. [Q96RR4-3 ]
NP_705720.1. NM_153500.1. [Q96RR4-5 ]
NP_757363.1. NM_172214.2. [Q96RR4-2 ]
NP_757364.1. NM_172215.2. [Q96RR4-6 ]
NP_757365.1. NM_172216.1. [Q96RR4-4 ]
NP_757380.1. NM_172226.2. [Q96RR4-3 ]
XP_005253880.1. XM_005253823.1. [Q96RR4-2 ]
XP_005253881.1. XM_005253824.2. [Q96RR4-5 ]
UniGenei Hs.297343.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ZV2 X-ray 2.40 A 158-448 [» ]
ProteinModelPortali Q96RR4.
SMRi Q96RR4. Positions 80-484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115889. 26 interactions.
IntActi Q96RR4. 19 interactions.

Chemistry

BindingDBi Q96RR4.
ChEMBLi CHEMBL5284.
GuidetoPHARMACOLOGYi 1957.

PTM databases

PhosphoSitei Q96RR4.

Polymorphism databases

DMDMi 317373374.

Proteomic databases

MaxQBi Q96RR4.
PaxDbi Q96RR4.
PRIDEi Q96RR4.

Protocols and materials databases

DNASUi 10645.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10645.
KEGGi hsa:10645.
UCSCi uc001tzt.3. human. [Q96RR4-3 ]
uc001tzu.3. human. [Q96RR4-1 ]
uc001tzw.3. human. [Q96RR4-4 ]
uc001tzy.3. human. [Q96RR4-5 ]
uc001uaa.2. human. [Q96RR4-7 ]
uc001uab.3. human. [Q96RR4-2 ]
uc001uac.3. human. [Q96RR4-6 ]

Organism-specific databases

CTDi 10645.
GeneCardsi GC12M121675.
H-InvDB HIX0011079.
HIX0171630.
HIX0171665.
HGNCi HGNC:1470. CAMKK2.
HPAi HPA017389.
MIMi 615002. gene.
neXtProti NX_Q96RR4.
PharmGKBi PA26052.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00530000063214.
HOVERGENi HBG052262.
InParanoidi Q96RR4.
KOi K07359.
OMAi MNGRCIC.
OrthoDBi EOG7F5114.
PhylomeDBi Q96RR4.
TreeFami TF313013.

Enzyme and pathway databases

SignaLinki Q96RR4.

Miscellaneous databases

ChiTaRSi CAMKK2. human.
EvolutionaryTracei Q96RR4.
GeneWikii CAMKK2.
GenomeRNAii 10645.
NextBioi 40461.
PROi Q96RR4.
SOURCEi Search...

Gene expression databases

Bgeei Q96RR4.
CleanExi HS_CAMKK2.
ExpressionAtlasi Q96RR4. baseline and differential.
Genevestigatori Q96RR4.

Family and domain databases

InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
PANTHERi PTHR24347. PTHR24347. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity."
    Hsu L.-S., Chen G.-D., Lee L.-S., Chi C.-W., Cheng J.-F., Chen J.-Y.
    J. Biol. Chem. 276:31113-31123(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), FUNCTION, VARIANT SER-85.
  2. "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta."
    Anderson K.A., Means R.L., Huang Q.-H., Kemp B.E., Goldstein E.G., Selbert M.A., Edelman A.M., Fremeau R.T., Means A.R.
    J. Biol. Chem. 273:31880-31889(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain cortex.
  3. "Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells."
    Ishikawa Y., Tokumitsu H., Inuzuka H., Murata-Hori M., Hosoya H., Kobayashi R.
    FEBS Lett. 550:57-63(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION IN PHOSPHORYLATION OF CAMK1D.
  4. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7), VARIANT SER-85.
    Tissue: Brain.
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Stomach.
  7. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 233-588 (ISOFORM 5), VARIANT SER-85.
    Tissue: Placenta.
  9. "Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase."
    Hsu L.-S., Tsou A.-P., Chi C.-W., Lee C.-H., Chen J.-Y.
    J. Biomed. Sci. 5:141-149(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 117-588 (ISOFORM 2), FUNCTION IN PHOSPHORYLATION OF CAMK1, TISSUE SPECIFICITY.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-588 (ISOFORM 7).
    Tissue: Amygdala.
  11. "Full-insert sequence of mapped XREF EST."
    Barrow I.K.-P., Boguski M.S., Touchman J.W., Spencer F.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 338-533 (ISOFORM 2).
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522 (ISOFORM 3), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-479 (ISOFORM 5), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation."
    Cao W., Sohail M., Liu G., Koumbadinga G.A., Lobo V.G., Xie J.
    RNA Biol. 8:1061-1072(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, AUTOPHOSPHORYLATION, PHOSPHORYLATION BY PKA, INDUCTION OF ISOFORM 1.
  15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  16. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-10; SER-85; TYR-123; LEU-127; THR-182 AND HIS-492.

Entry informationi

Entry nameiKKCC2_HUMAN
AccessioniPrimary (citable) accession number: Q96RR4
Secondary accession number(s): A8K7Q7
, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3