Reviewed, UniProtKB/Swiss-Prot Q96RR4 (KKCC2_HUMAN)

Names and origin

Protein names

Recommended name:
    Calcium/calmodulin-dependent protein kinase kinase 2
    EC=2.7.11.17
Alternative name(s):
    Calcium/calmodulin-dependent protein kinase kinase beta
      Short name=CaM-kinase kinase beta
      Short name=CaM-KK beta
      Short name=CaMKK beta

Gene names

Name:	CAMKK2
Synonyms:	CAMKKB, KIAA0787

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	588 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Seems to be involved in hippocampal activation of CREB1 By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Activated by Ca2+/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca2+/calmodulin. In part, activity is independent on Ca2+/calmodulin By similarity.
Subunit structure	Interacts with calmodulin By similarity.
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung. Ref.8
Domain	The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates By similarity.
Post-translational modification	Autophosphorylated By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.
Sequence caution	The sequence CAD38990.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Calmodulin-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	MAPKKK cascade Ref.1 Traceable author statement. Source: UniProtKB calcium-mediated signaling Ref.1 Traceable author statement. Source: UniProtKB positive regulation of transcription Ref.1 Traceable author statement. Source: UniProtKB protein amino acid autophosphorylation Ref.1 Inferred from direct assay. Source: UniProtKB regulation of protein kinase activity Ref.1 Traceable author statement. Source: UniProtKB
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium ion binding Ref.1 Inferred from direct assay. Source: UniProtKB calmodulin binding Ref.1 Traceable author statement. Source: UniProtKB calmodulin-dependent protein kinase activity Inferred from electronic annotation. Source: EC protein tyrosine kinase activity Ref.1 Traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96RR4-1)

Also known as: Beta1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Major isoform.

Isoform 2 (identifier: Q96RR4-2)

Also known as: Beta2;

The sequence of this isoform differs from the canonical sequence as follows:
     533-533: E → T
     534-554: Missing.
     555-588: Missing.

Note: Major isoform.

Isoform 3 (identifier: Q96RR4-3)

Also known as: Beta1delta16;

The sequence of this isoform differs from the canonical sequence as follows:
     520-532: KPTRECESLSELK → QGSEDNLQGTDPP
     533-541: EARQRRQPP → PVGEEEVLL
     542-554: Missing.
     555-588: Missing.

Note: Phosphorylated on Ser-522.

Isoform 4 (identifier: Q96RR4-4)

Also known as: Beta1delta14;

The sequence of this isoform differs from the canonical sequence as follows:
     442-484: Missing.

Note: Inactive. Does not activate CAMK1 and CAMK4. Phosphorylated on Ser-479.

Isoform 5 (identifier: Q96RR4-5)

Also known as: Beta1delta14/16; beta-3x;

The sequence of this isoform differs from the canonical sequence as follows:
     442-484: Missing.
     520-532: KPTRECESLSELK → QGSEDNLQGTDPP
     533-541: EARQRRQPP → PVGEEEVLL
     542-554: Missing.
     555-588: Missing.

Note: Inactive. Does not activate CAMK1 and CAMK4.

Isoform 6 (identifier: Q96RR4-6)

Also known as: Beta2delta14;

The sequence of this isoform differs from the canonical sequence as follows:
     442-484: Missing.
     533-533: E → T
     534-554: Missing.
     555-588: Missing.

Note: Inactive. Does not activate CAMK1 and CAMK4.

Isoform 7 (identifier: Q96RR4-7)

The sequence of this isoform differs from the canonical sequence as follows:
     533-554: EARQRRQPPGHRPAPRGGGGSA → GTKKKKGLDSMTSTVAAGWLDRRV
     555-588: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 588	588	Calcium/calmodulin-dependent protein kinase kinase 2		PRO_0000086144
Regions
	Domain	165 – 446	282	Protein kinase
	Nucleotide binding	171 – 179	9	ATP By similarity
	Region	204 – 226	23	RP domain
	Region	472 – 477	6	Autoinhibitory domain By similarity
	Region	475 – 500	26	Calmodulin-binding By similarity
Sites
	Active site	312	1	Proton acceptor By similarity
	Binding site	194	1	ATP By similarity
Amino acid modifications
	Modified residue	129	1	Phosphoserine By similarity
	Modified residue	133	1	Phosphoserine By similarity
	Modified residue	495	1	Phosphoserine Ref.11
	Modified residue	511	1	Phosphoserine Ref.11
Natural variations
	Alternative sequence	442 – 484	43	Missing in isoform 4, isoform 5 and isoform 6.		VSP_012142
	Alternative sequence	520 – 532	13	KPTRE…LSELK → QGSEDNLQGTDPP in isoform 3 and isoform 5.		VSP_012143
	Alternative sequence	533 – 554	22	EARQR…GGGSA → GTKKKKGLDSMTSTVAAGWL DRRV in isoform 7.		VSP_012148
	Alternative sequence	533 – 541	9	EARQRRQPP → PVGEEEVLL in isoform 3 and isoform 5.		VSP_012144
	Alternative sequence	533	1	E → T in isoform 2 and isoform 6.		VSP_012146
	Alternative sequence	534 – 554	21	Missing in isoform 2 and isoform 6.		VSP_012147
	Alternative sequence	542 – 554	13	Missing in isoform 3 and isoform 5.		VSP_012145
	Alternative sequence	555 – 588	34	Missing in isoform 2, isoform 3, isoform 5, isoform 6 and isoform 7.		VSP_012149
	Natural variant	10	1	S → N: dbSNP rs28360477. Ref.12		VAR_032788
	Natural variant	85	1	S → T: dbSNP rs3817190. Ref.12 Ref.1 Ref.2 Ref.3 Ref.6		VAR_020532
	Natural variant	123	1	C → Y		VAR_040610
	Natural variant	127	1	P → L in a lung neuroendocrine carcinoma sample; somatic mutation. Ref.12		VAR_040611
	Natural variant	182	1	A → T in a colorectal adenocarcinoma sample; somatic mutation. Ref.12		VAR_040612
	Natural variant	363	1	R → C: dbSNP rs1132780.		VAR_020533
	Natural variant	492	1	R → H		VAR_040613
Experimental info
	Sequence conflict	206	1	G → A in AAD31507. Ref.2
	Sequence conflict	331	1	F → I in BAF84761. Ref.6
	Sequence conflict	347	1	T → Y in AAD31507. Ref.2
	Sequence conflict	371	1	L → K in AAD31507. Ref.2
	Sequence conflict	554	1	A → H in AAK91829. Ref.1
	Sequence conflict	557	1	R → N in AAK91829. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Beta1) [UniParc]. Last modified December 1, 2001. Version 1. Checksum: D4C4583561341166	FASTA	588	64,732
	10 20 30 40 50 60 MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP 70 80 90 100 110 120 GCAVDLGLAR DRPLEADGQE VPLDSSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR 130 140 150 160 170 180 CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK 190 200 210 220 230 240 LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL 250 260 270 280 290 300 KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 310 320 330 340 350 360 EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS 370 380 390 400 410 420 ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK 430 440 450 460 470 480 DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS 490 500 510 520 530 540 LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKK PTRECESLSE LKEARQRRQP 550 560 570 580 PGHRPAPRGG GGSALVRGSP CVESCWAPAP GSPARMHPLR PEEAMEPE
	Isoform 2 (Beta2). Checksum: 55B830B6EE4B678D	FASTA	533	58,885
	10 20 30 40 50 60 MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP 70 80 90 100 110 120 GCAVDLGLAR DRPLEADGQE VPLDSSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR 130 140 150 160 170 180 CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK 190 200 210 220 230 240 LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL 250 260 270 280 290 300 KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 310 320 330 340 350 360 EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS 370 380 390 400 410 420 ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK 430 440 450 460 470 480 DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS 490 500 510 520 530 LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKK PTRECESLSE LKT
	Isoform 3 (Beta1delta16). Checksum: 3D3AC0943A7D7941	FASTA	541	59,588
	10 20 30 40 50 60 MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP 70 80 90 100 110 120 GCAVDLGLAR DRPLEADGQE VPLDSSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR 130 140 150 160 170 180 CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK 190 200 210 220 230 240 LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL 250 260 270 280 290 300 KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 310 320 330 340 350 360 EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS 370 380 390 400 410 420 ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK 430 440 450 460 470 480 DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS 490 500 510 520 530 540 LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKQ GSEDNLQGTD PPPVGEEEVL L
	Isoform 4 (Beta1delta14). Checksum: 81A4693B94DEC76A	FASTA	545	59,956
	10 20 30 40 50 60 MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP 70 80 90 100 110 120 GCAVDLGLAR DRPLEADGQE VPLDSSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR 130 140 150 160 170 180 CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK 190 200 210 220 230 240 LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL 250 260 270 280 290 300 KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 310 320 330 340 350 360 EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS 370 380 390 400 410 420 ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK 430 440 450 460 470 480 DLITRMLDKN PESRIVVPEI KILVKTMIRK RSFGNPFEGS RREERSLSAP GNLLTKKPTR 490 500 510 520 530 540 ECESLSELKE ARQRRQPPGH RPAPRGGGGS ALVRGSPCVE SCWAPAPGSP ARMHPLRPEE AMEPE
	Isoform 5 (Beta1delta14/16) (beta-3x). Checksum: 13CD63012E40C05B	FASTA	498	54,813
	10 20 30 40 50 60 MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP 70 80 90 100 110 120 GCAVDLGLAR DRPLEADGQE VPLDSSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR 130 140 150 160 170 180 CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK 190 200 210 220 230 240 LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL 250 260 270 280 290 300 KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 310 320 330 340 350 360 EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS 370 380 390 400 410 420 ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK 430 440 450 460 470 480 DLITRMLDKN PESRIVVPEI KILVKTMIRK RSFGNPFEGS RREERSLSAP GNLLTKQGSE 490 DNLQGTDPPP VGEEEVLL
	Isoform 6 (Beta2delta14). Checksum: 074243C1E97BAF7F	FASTA	490	54,110
	10 20 30 40 50 60 MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP 70 80 90 100 110 120 GCAVDLGLAR DRPLEADGQE VPLDSSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR 130 140 150 160 170 180 CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK 190 200 210 220 230 240 LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL 250 260 270 280 290 300 KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 310 320 330 340 350 360 EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS 370 380 390 400 410 420 ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK 430 440 450 460 470 480 DLITRMLDKN PESRIVVPEI KILVKTMIRK RSFGNPFEGS RREERSLSAP GNLLTKKPTR 490 ECESLSELKT
	Isoform 7. Checksum: 4945AA1868EA563B	FASTA	556	61,372
	10 20 30 40 50 60 MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP 70 80 90 100 110 120 GCAVDLGLAR DRPLEADGQE VPLDSSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR 130 140 150 160 170 180 CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK 190 200 210 220 230 240 LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL 250 260 270 280 290 300 KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 310 320 330 340 350 360 EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS 370 380 390 400 410 420 ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK 430 440 450 460 470 480 DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS 490 500 510 520 530 540 LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKK PTRECESLSE LKGTKKKKGL 550 DSMTSTVAAG WLDRRV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity." Hsu L.-S., Chen G.-D., Lee L.-S., Chi C.-W., Cheng J.-F., Chen J.-Y. J. Biol. Chem. 276:31113-31123(2001) [PubMed: 11395482] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), FUNCTION, VARIANT THR-85.
[2]	"Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta." Anderson K.A., Means R.L., Huang Q.-H., Kemp B.E., Goldstein E.G., Selbert M.A., Edelman A.M., Fremeau R.T., Means A.R. J. Biol. Chem. 273:31880-31889(1998) [PubMed: 9822657] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-85. Tissue: Brain cortex.
[3]	"Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells." Ishikawa Y., Tokumitsu H., Inuzuka H., Murata-Hori M., Hosoya H., Kobayashi R. FEBS Lett. 550:57-63(2003) [PubMed: 12935886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION IN PHOSPHORYLATION OF CAMK1D, VARIANT THR-85.
[4]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed: 9872452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). Tissue: Brain.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT THR-85. Tissue: Stomach.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 233-588 (ISOFORM 5). Tissue: Placenta.
[8]	"Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase." Hsu L.-S., Tsou A.-P., Chi C.-W., Lee C.-H., Chen J.-Y. J. Biomed. Sci. 5:141-149(1998) [PubMed: 9662074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 117-588 (ISOFORM 2), FUNCTION IN PHOSPHORYLATION OF CAMK1, TISSUE SPECIFICITY.
[9]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-588 (ISOFORM 7). Tissue: Amygdala.
[10]	"Full-insert sequence of mapped XREF EST." Barrow I.K.-P., Boguski M.S., Touchman J.W., Spencer F. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 338-533 (ISOFORM 2).
[11]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495 AND SER-511, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522 (ISOFORM 3), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-479 (ISOFORM 5), MASS SPECTROMETRY.
[12]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-10; THR-85; TYR-123; LEU-127; THR-182 AND HIS-492.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB081337 mRNA. Translation: BAC19841.1. AF287630 mRNA. Translation: AAK64600.1. AF287631 mRNA. Translation: AAK64601.1. AF321385 mRNA. Translation: AAL37215.1. AF321386 mRNA. Translation: AAL37216.1. AF321387 mRNA. Translation: AAL37217.1. AF321388 mRNA. Translation: AAL37218.1. AF321401 , AF321390, AF321391, AF321392, AF321393, AF321394, AF321395, AF321396, AF321397, AF321398, AF321399, AF321400, AF321575, AF321576, AF321577, AF321578 Genomic DNA. Translation: AAK91830.1. AF321402 , AF321390, AF321391, AF321392, AF321393, AF321394, AF321395, AF321396, AF321397, AF321398, AF321399, AF321400, AF321575, AF321576, AF321577, AF321578 Genomic DNA. Translation: AAK91829.1. AF140507 mRNA. Translation: AAD31507.1. AB081336 mRNA. Translation: BAC19840.1. AB018330 mRNA. Translation: BAA34507.2. Different initiation. AK292072 mRNA. Translation: BAF84761.1. BC000318 mRNA. Translation: AAH00318.2. BC026060 mRNA. Translation: AAH26060.1. AF101264 mRNA. Translation: AAD04566.1. AL834322 mRNA. Translation: CAD38990.1. Sequence problems. AF091074 mRNA. Translation: AAC72943.1. Different initiation.
IPI	IPI00170509. IPI00172426. IPI00172500. IPI00172501. IPI00290239. IPI00292156. IPI00479420.
PIR	JE0191.
RefSeq	NP_006540.3. NP_705719.2. NP_705720.1. NP_757363.1. NP_757364.1. NP_757365.1. NP_757380.1.
UniGene	Hs.297343
3D structure databases
HSSP	HSSP built from PDB template 1OL6 based on UniProtKB O14965.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96RR4. 5 interactions.
STRING	Q96RR4.
PTM databases
PhosphoSite	Q96RR4.
Proteomic databases
PRIDE	Q96RR4.
Genome annotation databases
Ensembl	ENST00000324774; ENSP00000312741; ENSG00000110931; Homo sapiens. [Genome view] ENST00000337174; ENSP00000336634; ENSG00000110931; Homo sapiens. [Genome view] ENST00000347034; ENSP00000321230; ENSG00000110931; Homo sapiens. [Genome view] ENST00000360452; ENSP00000353636; ENSG00000110931; Homo sapiens. [Genome view] ENST00000392473; ENSP00000376265; ENSG00000110931; Homo sapiens. [Genome view] ENST00000392474; ENSP00000376266; ENSG00000110931; Homo sapiens. [Genome view] ENST00000402834; ENSP00000384591; ENSG00000110931; Homo sapiens. [Genome view] ENST00000404169; ENSP00000384600; ENSG00000110931; Homo sapiens. [Genome view] ENST00000412367; ENSP00000388368; ENSG00000110931; Homo sapiens. [Genome view] ENST00000446440; ENSP00000388273; ENSG00000110931; Homo sapiens. [Genome view]
GeneID	10645.
KEGG	hsa:10645.
UCSC	uc001tzt.1. human. uc001tzu.1. human. uc001tzw.1. human. uc001tzy.1. human. uc001uaa.1. human. uc001uab.1. human. uc001uac.1. human.
Organism-specific databases
CTD	10645.
GeneCards	GC12M120138.
H-InvDB	HIX0011079.
HGNC	HGNC:1470. CAMKK2.
HPA	HPA017389.
PharmGKB	PA26052.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q96RR4.
Enzyme and pathway databases
BRENDA	2.7.11.17. 247.
Gene expression databases
ArrayExpress	Q96RR4.
Bgee	Q96RR4.
CleanEx	HS_CAMKK2.
Genevestigator	Q96RR4.
GermOnline	ENSG00000110931. Homo sapiens.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	40461.

Entry information

Entry name

KKCC2_HUMAN

Accession

Primary (citable) accession number: Q96RR4
Secondary accession number(s): A8K7Q7 , O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	December 1, 2001
Last modified:	October 13, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.