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Protein

Calcium/calmodulin-dependent protein kinase kinase 2

Gene

CAMKK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca2+ signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.By similarity4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by Ca2+/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca2+/calmodulin. In part, activity is independent on Ca2+/calmodulin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei194ATPPROSITE-ProRule annotation1
Active sitei312Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi171 – 179ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium ion binding Source: UniProtKB
  • calmodulin binding Source: UniProtKB
  • calmodulin-dependent protein kinase activity Source: UniProtKB-EC
  • protein tyrosine kinase activity Source: UniProtKB

GO - Biological processi

  • calcium-mediated signaling Source: UniProtKB
  • MAPK cascade Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • protein autophosphorylation Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • regulation of protein kinase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS03356-MONOMER.
BRENDAi2.7.11.17. 2681.
SignaLinkiQ96RR4.
SIGNORiQ96RR4.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase kinase 2 (EC:2.7.11.17)
Short name:
CaM-KK 2
Short name:
CaM-kinase kinase 2
Short name:
CaMKK 2
Alternative name(s):
Calcium/calmodulin-dependent protein kinase kinase beta
Short name:
CaM-KK beta
Short name:
CaM-kinase kinase beta
Short name:
CaMKK beta
Gene namesi
Name:CAMKK2
Synonyms:CAMKKB, KIAA0787
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:1470. CAMKK2.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm 1 Publication
  • Cell projection 1 Publication

  • Note: Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction.By similarity

GO - Cellular componenti

  • cell projection Source: UniProtKB-SubCell
  • cytoplasm Source: HPA
  • intracellular Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10645.
OpenTargetsiENSG00000110931.
PharmGKBiPA26052.

Chemistry databases

ChEMBLiCHEMBL5284.
GuidetoPHARMACOLOGYi1957.

Polymorphism and mutation databases

BioMutaiCAMKK2.
DMDMi317373374.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000861442 – 588Calcium/calmodulin-dependent protein kinase kinase 2Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei100PhosphoserineBy similarity1
Modified residuei114PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei133PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei495PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei572PhosphoserineBy similarity1
Isoform 5 (identifier: Q96RR4-5)
Modified residuei479PhosphoserineCombined sources1
Isoform 3 (identifier: Q96RR4-3)
Modified residuei522PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96RR4.
MaxQBiQ96RR4.
PaxDbiQ96RR4.
PeptideAtlasiQ96RR4.
PRIDEiQ96RR4.

PTM databases

iPTMnetiQ96RR4.
PhosphoSitePlusiQ96RR4.

Expressioni

Tissue specificityi

Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.1 Publication

Inductioni

Isoform 1 is up-regulated by PKA pathway.1 Publication

Gene expression databases

BgeeiENSG00000110931.
CleanExiHS_CAMKK2.
ExpressionAtlasiQ96RR4. baseline and differential.
GenevisibleiQ96RR4. HS.

Organism-specific databases

HPAiHPA017389.

Interactioni

Subunit structurei

Interacts with calmodulin.By similarity

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115889. 29 interactors.
IntActiQ96RR4. 19 interactors.
STRINGi9606.ENSP00000312741.

Chemistry databases

BindingDBiQ96RR4.

Structurei

Secondary structure

1588
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi165 – 172Combined sources8
Beta strandi178 – 184Combined sources7
Turni185 – 188Combined sources4
Beta strandi189 – 197Combined sources9
Helixi232 – 241Combined sources10
Beta strandi251 – 256Combined sources6
Beta strandi258 – 268Combined sources11
Helixi286 – 305Combined sources20
Helixi315 – 317Combined sources3
Beta strandi318 – 320Combined sources3
Beta strandi326 – 328Combined sources3
Beta strandi338 – 341Combined sources4
Helixi351 – 353Combined sources3
Helixi356 – 358Combined sources3
Beta strandi366 – 368Combined sources3
Helixi369 – 385Combined sources17
Helixi395 – 404Combined sources10
Beta strandi411 – 413Combined sources3
Helixi417 – 426Combined sources10
Turni431 – 433Combined sources3
Helixi437 – 440Combined sources4
Helixi444 – 447Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZV2X-ray2.40A158-448[»]
ProteinModelPortaliQ96RR4.
SMRiQ96RR4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96RR4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 446Protein kinasePROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni204 – 226RP domainAdd BLAST23
Regioni472 – 477Autoinhibitory domainBy similarity6
Regioni475 – 500Calmodulin-bindingBy similarityAdd BLAST26

Domaini

The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.By similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0585. Eukaryota.
ENOG410YHHF. LUCA.
GeneTreeiENSGT00530000063214.
HOVERGENiHBG052262.
InParanoidiQ96RR4.
KOiK07359.
OMAiMNGRCIC.
OrthoDBiEOG091G01DB.
PhylomeDBiQ96RR4.
TreeFamiTF313013.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96RR4-1) [UniParc]FASTAAdd to basket
Also known as: Beta1, CAMKK2+E16

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME
60 70 80 90 100
SFIVVTECEP GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS
110 120 130 140 150
LQERSQGGLA AGGSLDMNGR CICPSLPYSP VSSPQSSPRL PRRPTVESHH
160 170 180 190 200
VSITGMQDCV QLNQYTLKDE IGKGSYGVVK LAYNENDNTY YAMKVLSKKK
210 220 230 240 250
LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL KKLDHPNVVK
260 270 280 290 300
LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI
310 320 330 340 350
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT
360 370 380 390 400
PAFMAPESLS ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS
410 420 430 440 450
KIKSQALEFP DQPDIAEDLK DLITRMLDKN PESRIVVPEI KLHPWVTRHG
460 470 480 490 500
AEPLPSEDEN CTLVEVTEEE VENSVKHIPS LATVILVKTM IRKRSFGNPF
510 520 530 540 550
EGSRREERSL SAPGNLLTKK PTRECESLSE LKEARQRRQP PGHRPAPRGG
560 570 580
GGSALVRGSP CVESCWAPAP GSPARMHPLR PEEAMEPE
Note: Major isoform.
Length:588
Mass (Da):64,746
Last modified:January 11, 2011 - v2
Checksum:i04E3583561341167
GO
Isoform 2 (identifier: Q96RR4-2) [UniParc]FASTAAdd to basket
Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
     533-533: E → T
     534-554: Missing.
     555-588: Missing.

Note: Major isoform.
Show »
Length:533
Mass (Da):58,899
Checksum:i98FAAB0FB8C4CACF
GO
Isoform 3 (identifier: Q96RR4-3) [UniParc]FASTAAdd to basket
Also known as: Beta1delta16, CAMKK2-E16

The sequence of this isoform differs from the canonical sequence as follows:
     520-532: KPTRECESLSELK → QGSEDNLQGTDPP
     533-541: EARQRRQPP → PVGEEEVLL
     542-554: Missing.
     555-588: Missing.

Show »
Length:541
Mass (Da):59,602
Checksum:iD9A56C3D780C0DDE
GO
Isoform 4 (identifier: Q96RR4-4) [UniParc]FASTAAdd to basket
Also known as: Beta1delta14

The sequence of this isoform differs from the canonical sequence as follows:
     442-484: Missing.

Show »
Length:545
Mass (Da):59,971
Checksum:iEE849E31E0416BC3
GO
Isoform 5 (identifier: Q96RR4-5) [UniParc]FASTAAdd to basket
Also known as: Beta1delta14/16, beta-3x

The sequence of this isoform differs from the canonical sequence as follows:
     442-484: Missing.
     520-532: KPTRECESLSELK → QGSEDNLQGTDPP
     533-541: EARQRRQPP → PVGEEEVLL
     542-554: Missing.
     555-588: Missing.

Note: Inactive. Does not activate CAMK1 and CAMK4.Combined sources
Show »
Length:498
Mass (Da):54,827
Checksum:i6D051947DDCB69E1
GO
Isoform 6 (identifier: Q96RR4-6) [UniParc]FASTAAdd to basket
Also known as: Beta2delta14

The sequence of this isoform differs from the canonical sequence as follows:
     442-484: Missing.
     533-533: E → T
     534-554: Missing.
     555-588: Missing.

Note: Inactive. Does not activate CAMK1 and CAMK4.
Show »
Length:490
Mass (Da):54,124
Checksum:i0821956F65E543C4
GO
Isoform 7 (identifier: Q96RR4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     533-554: EARQRRQPPGHRPAPRGGGGSA → GTKKKKGLDSMTSTVAAGWLDRRV
     555-588: Missing.

Show »
Length:556
Mass (Da):61,386
Checksum:i47E33706CE77489C
GO

Sequence cautioni

The sequence AAC72943 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA34507 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD38990 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206G → A in AAD31507 (PubMed:9822657).Curated1
Sequence conflicti331F → I in BAF84761 (PubMed:14702039).Curated1
Sequence conflicti347T → Y in AAD31507 (PubMed:9822657).Curated1
Sequence conflicti371L → K in AAD31507 (PubMed:9822657).Curated1
Sequence conflicti554A → H in AAK91829 (PubMed:11395482).Curated1
Sequence conflicti557R → N in AAK91829 (PubMed:11395482).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03278810S → N.1 PublicationCorresponds to variant rs28360477dbSNPEnsembl.1
Natural variantiVAR_02053285T → S.4 PublicationsCorresponds to variant rs3817190dbSNPEnsembl.1
Natural variantiVAR_040610123C → Y.1 PublicationCorresponds to variant rs35403710dbSNPEnsembl.1
Natural variantiVAR_040611127P → L in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040612182A → T in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_020533363R → C.Corresponds to variant rs1132780dbSNPEnsembl.1
Natural variantiVAR_040613492R → H.1 PublicationCorresponds to variant rs34129994dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012142442 – 484Missing in isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_012143520 – 532KPTRE…LSELK → QGSEDNLQGTDPP in isoform 3 and isoform 5. 4 PublicationsAdd BLAST13
Alternative sequenceiVSP_012148533 – 554EARQR…GGGSA → GTKKKKGLDSMTSTVAAGWL DRRV in isoform 7. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_012144533 – 541EARQRRQPP → PVGEEEVLL in isoform 3 and isoform 5. 4 Publications9
Alternative sequenceiVSP_012146533E → T in isoform 2 and isoform 6. 3 Publications1
Alternative sequenceiVSP_012147534 – 554Missing in isoform 2 and isoform 6. 3 PublicationsAdd BLAST21
Alternative sequenceiVSP_012145542 – 554Missing in isoform 3 and isoform 5. 4 PublicationsAdd BLAST13
Alternative sequenceiVSP_012149555 – 588Missing in isoform 2, isoform 3, isoform 5, isoform 6 and isoform 7. 8 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081337 mRNA. Translation: BAC19841.1.
AF287630 mRNA. Translation: AAK64600.1.
AF287631 mRNA. Translation: AAK64601.1.
AF321385 mRNA. Translation: AAL37215.1.
AF321386 mRNA. Translation: AAL37216.1.
AF321387 mRNA. Translation: AAL37217.1.
AF321388 mRNA. Translation: AAL37218.1.
AF321401
, AF321390, AF321391, AF321392, AF321393, AF321394, AF321395, AF321396, AF321397, AF321398, AF321399, AF321400, AF321575, AF321576, AF321577, AF321578 Genomic DNA. Translation: AAK91830.1.
AF321402
, AF321390, AF321391, AF321392, AF321393, AF321394, AF321395, AF321396, AF321397, AF321398, AF321399, AF321400, AF321575, AF321576, AF321577, AF321578 Genomic DNA. Translation: AAK91829.1.
AF140507 mRNA. Translation: AAD31507.1.
AB081336 mRNA. Translation: BAC19840.1.
AB018330 mRNA. Translation: BAA34507.2. Different initiation.
AK292072 mRNA. Translation: BAF84761.1.
AC069209 Genomic DNA. No translation available.
BC000318 mRNA. Translation: AAH00318.2.
BC026060 mRNA. Translation: AAH26060.1.
AF101264 mRNA. Translation: AAD04566.1.
AL834322 mRNA. Translation: CAD38990.1. Sequence problems.
AF091074 mRNA. Translation: AAC72943.1. Different initiation.
CCDSiCCDS44999.1. [Q96RR4-2]
CCDS53837.1. [Q96RR4-6]
CCDS58283.1. [Q96RR4-7]
CCDS9216.1. [Q96RR4-1]
CCDS9217.1. [Q96RR4-4]
CCDS9218.1. [Q96RR4-3]
CCDS9219.1. [Q96RR4-5]
PIRiJE0191.
RefSeqiNP_001257414.1. NM_001270485.1. [Q96RR4-1]
NP_001257415.1. NM_001270486.1. [Q96RR4-7]
NP_006540.3. NM_006549.3. [Q96RR4-1]
NP_705719.2. NM_153499.2. [Q96RR4-3]
NP_705720.1. NM_153500.1. [Q96RR4-5]
NP_757363.1. NM_172214.2. [Q96RR4-2]
NP_757364.1. NM_172215.2. [Q96RR4-6]
NP_757365.1. NM_172216.1. [Q96RR4-4]
NP_757380.1. NM_172226.2. [Q96RR4-3]
XP_005253880.1. XM_005253823.1. [Q96RR4-2]
XP_005253881.1. XM_005253824.3. [Q96RR4-5]
XP_011536065.1. XM_011537763.1. [Q96RR4-7]
XP_016874187.1. XM_017018698.1. [Q96RR4-1]
XP_016874190.1. XM_017018701.1. [Q96RR4-7]
XP_016874191.1. XM_017018702.1. [Q96RR4-7]
XP_016874193.1. XM_017018704.1. [Q96RR4-2]
UniGeneiHs.297343.

Genome annotation databases

EnsembliENST00000324774; ENSP00000312741; ENSG00000110931. [Q96RR4-1]
ENST00000337174; ENSP00000336634; ENSG00000110931. [Q96RR4-3]
ENST00000347034; ENSP00000321230; ENSG00000110931. [Q96RR4-4]
ENST00000392473; ENSP00000376265; ENSG00000110931. [Q96RR4-2]
ENST00000392474; ENSP00000376266; ENSG00000110931. [Q96RR4-7]
ENST00000402834; ENSP00000384591; ENSG00000110931. [Q96RR4-1]
ENST00000404169; ENSP00000384600; ENSG00000110931. [Q96RR4-1]
ENST00000412367; ENSP00000388368; ENSG00000110931. [Q96RR4-3]
ENST00000446440; ENSP00000388273; ENSG00000110931. [Q96RR4-6]
ENST00000538733; ENSP00000445944; ENSG00000110931. [Q96RR4-5]
GeneIDi10645.
KEGGihsa:10645.
UCSCiuc001tzt.4. human. [Q96RR4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081337 mRNA. Translation: BAC19841.1.
AF287630 mRNA. Translation: AAK64600.1.
AF287631 mRNA. Translation: AAK64601.1.
AF321385 mRNA. Translation: AAL37215.1.
AF321386 mRNA. Translation: AAL37216.1.
AF321387 mRNA. Translation: AAL37217.1.
AF321388 mRNA. Translation: AAL37218.1.
AF321401
, AF321390, AF321391, AF321392, AF321393, AF321394, AF321395, AF321396, AF321397, AF321398, AF321399, AF321400, AF321575, AF321576, AF321577, AF321578 Genomic DNA. Translation: AAK91830.1.
AF321402
, AF321390, AF321391, AF321392, AF321393, AF321394, AF321395, AF321396, AF321397, AF321398, AF321399, AF321400, AF321575, AF321576, AF321577, AF321578 Genomic DNA. Translation: AAK91829.1.
AF140507 mRNA. Translation: AAD31507.1.
AB081336 mRNA. Translation: BAC19840.1.
AB018330 mRNA. Translation: BAA34507.2. Different initiation.
AK292072 mRNA. Translation: BAF84761.1.
AC069209 Genomic DNA. No translation available.
BC000318 mRNA. Translation: AAH00318.2.
BC026060 mRNA. Translation: AAH26060.1.
AF101264 mRNA. Translation: AAD04566.1.
AL834322 mRNA. Translation: CAD38990.1. Sequence problems.
AF091074 mRNA. Translation: AAC72943.1. Different initiation.
CCDSiCCDS44999.1. [Q96RR4-2]
CCDS53837.1. [Q96RR4-6]
CCDS58283.1. [Q96RR4-7]
CCDS9216.1. [Q96RR4-1]
CCDS9217.1. [Q96RR4-4]
CCDS9218.1. [Q96RR4-3]
CCDS9219.1. [Q96RR4-5]
PIRiJE0191.
RefSeqiNP_001257414.1. NM_001270485.1. [Q96RR4-1]
NP_001257415.1. NM_001270486.1. [Q96RR4-7]
NP_006540.3. NM_006549.3. [Q96RR4-1]
NP_705719.2. NM_153499.2. [Q96RR4-3]
NP_705720.1. NM_153500.1. [Q96RR4-5]
NP_757363.1. NM_172214.2. [Q96RR4-2]
NP_757364.1. NM_172215.2. [Q96RR4-6]
NP_757365.1. NM_172216.1. [Q96RR4-4]
NP_757380.1. NM_172226.2. [Q96RR4-3]
XP_005253880.1. XM_005253823.1. [Q96RR4-2]
XP_005253881.1. XM_005253824.3. [Q96RR4-5]
XP_011536065.1. XM_011537763.1. [Q96RR4-7]
XP_016874187.1. XM_017018698.1. [Q96RR4-1]
XP_016874190.1. XM_017018701.1. [Q96RR4-7]
XP_016874191.1. XM_017018702.1. [Q96RR4-7]
XP_016874193.1. XM_017018704.1. [Q96RR4-2]
UniGeneiHs.297343.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZV2X-ray2.40A158-448[»]
ProteinModelPortaliQ96RR4.
SMRiQ96RR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115889. 29 interactors.
IntActiQ96RR4. 19 interactors.
STRINGi9606.ENSP00000312741.

Chemistry databases

BindingDBiQ96RR4.
ChEMBLiCHEMBL5284.
GuidetoPHARMACOLOGYi1957.

PTM databases

iPTMnetiQ96RR4.
PhosphoSitePlusiQ96RR4.

Polymorphism and mutation databases

BioMutaiCAMKK2.
DMDMi317373374.

Proteomic databases

EPDiQ96RR4.
MaxQBiQ96RR4.
PaxDbiQ96RR4.
PeptideAtlasiQ96RR4.
PRIDEiQ96RR4.

Protocols and materials databases

DNASUi10645.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324774; ENSP00000312741; ENSG00000110931. [Q96RR4-1]
ENST00000337174; ENSP00000336634; ENSG00000110931. [Q96RR4-3]
ENST00000347034; ENSP00000321230; ENSG00000110931. [Q96RR4-4]
ENST00000392473; ENSP00000376265; ENSG00000110931. [Q96RR4-2]
ENST00000392474; ENSP00000376266; ENSG00000110931. [Q96RR4-7]
ENST00000402834; ENSP00000384591; ENSG00000110931. [Q96RR4-1]
ENST00000404169; ENSP00000384600; ENSG00000110931. [Q96RR4-1]
ENST00000412367; ENSP00000388368; ENSG00000110931. [Q96RR4-3]
ENST00000446440; ENSP00000388273; ENSG00000110931. [Q96RR4-6]
ENST00000538733; ENSP00000445944; ENSG00000110931. [Q96RR4-5]
GeneIDi10645.
KEGGihsa:10645.
UCSCiuc001tzt.4. human. [Q96RR4-1]

Organism-specific databases

CTDi10645.
DisGeNETi10645.
GeneCardsiCAMKK2.
H-InvDBHIX0011079.
HIX0171630.
HIX0171665.
HGNCiHGNC:1470. CAMKK2.
HPAiHPA017389.
MIMi615002. gene.
neXtProtiNX_Q96RR4.
OpenTargetsiENSG00000110931.
PharmGKBiPA26052.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0585. Eukaryota.
ENOG410YHHF. LUCA.
GeneTreeiENSGT00530000063214.
HOVERGENiHBG052262.
InParanoidiQ96RR4.
KOiK07359.
OMAiMNGRCIC.
OrthoDBiEOG091G01DB.
PhylomeDBiQ96RR4.
TreeFamiTF313013.

Enzyme and pathway databases

BioCyciZFISH:HS03356-MONOMER.
BRENDAi2.7.11.17. 2681.
SignaLinkiQ96RR4.
SIGNORiQ96RR4.

Miscellaneous databases

ChiTaRSiCAMKK2. human.
EvolutionaryTraceiQ96RR4.
GeneWikiiCAMKK2.
GenomeRNAii10645.
PROiQ96RR4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110931.
CleanExiHS_CAMKK2.
ExpressionAtlasiQ96RR4. baseline and differential.
GenevisibleiQ96RR4. HS.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKKCC2_HUMAN
AccessioniPrimary (citable) accession number: Q96RR4
Secondary accession number(s): A8K7Q7
, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.