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Protein

L-amino-acid oxidase

Gene

IL4I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity).By similarity

Catalytic activityi

An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei89FADBy similarity1
Binding sitei97FADBy similarity1
Binding sitei116SubstrateBy similarity1
Binding sitei287FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei398SubstrateBy similarity1
Binding sitei481FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi115 – 116FADBy similarity2
Nucleotide bindingi490 – 493FADBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciZFISH:HS02660-MONOMER.
ReactomeiR-HSA-71182. Phenylalanine and tyrosine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
L-amino-acid oxidase (EC:1.4.3.2)
Short name:
LAAO
Short name:
LAO
Alternative name(s):
Interleukin-4-induced protein 1
Short name:
IL4-induced protein 1
Protein Fig-1
Short name:
hFIG1
Gene namesi
Name:IL4I1
Synonyms:FIG1
ORF Names:UNQ636/PRO1265
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:19094. IL4I1.

Subcellular locationi

Isoform 1 :
Isoform 2 :

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi259307.
OpenTargetsiENSG00000104951.
PharmGKBiPA38795.

Chemistry databases

DrugBankiDB03147. Flavin adenine dinucleotide.

Polymorphism and mutation databases

BioMutaiIL4I1.
DMDMi20138284.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000000171022 – 567L-amino-acid oxidaseAdd BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 199By similarity
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Glycosylationi220N-linked (GlcNAc...)1 Publication1
Glycosylationi559N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ96RQ9.
PaxDbiQ96RQ9.
PeptideAtlasiQ96RQ9.
PRIDEiQ96RQ9.

PTM databases

iPTMnetiQ96RQ9.
PhosphoSitePlusiQ96RQ9.

Expressioni

Tissue specificityi

Isoform 1 is primarily found in immune tissues.1 Publication

Inductioni

By IL4/interleukin-4.

Gene expression databases

BgeeiENSG00000104951.
ExpressionAtlasiQ96RQ9. baseline and differential.
GenevisibleiQ96RQ9. HS.

Organism-specific databases

HPAiHPA045598.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342557.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I8Hmodel-@30-504[»]
ProteinModelPortaliQ96RQ9.
SMRiQ96RQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEXX. Eukaryota.
COG1231. LUCA.
GeneTreeiENSGT00730000110942.
HOGENOMiHOG000088141.
HOVERGENiHBG005729.
InParanoidiQ96RQ9.
KOiK03334.
OMAiVDPFDSI.
OrthoDBiEOG091G0412.
PhylomeDBiQ96RQ9.
TreeFamiTF313314.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96RQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPLALHLLV LVPILLSLVA SQDWKAERSQ DPFEKCMQDP DYEQLLKVVT
60 70 80 90 100
WGLNRTLKPQ RVIVVGAGVA GLVAAKVLSD AGHKVTILEA DNRIGGRIFT
110 120 130 140 150
YRDQNTGWIG ELGAMRMPSS HRILHKLCQG LGLNLTKFTQ YDKNTWTEVH
160 170 180 190 200
EVKLRNYVVE KVPEKLGYAL RPQEKGHSPE DIYQMALNQA LKDLKALGCR
210 220 230 240 250
KAMKKFERHT LLEYLLGEGN LSRPAVQLLG DVMSEDGFFY LSFAEALRAH
260 270 280 290 300
SCLSDRLQYS RIVGGWDLLP RALLSSLSGL VLLNAPVVAM TQGPHDVHVQ
310 320 330 340 350
IETSPPARNL KVLKADVVLL TASGPAVKRI TFSPPLPRHM QEALRRLHYV
360 370 380 390 400
PATKVFLSFR RPFWREEHIE GGHSNTDRPS RMIFYPPPRE GALLLASYTW
410 420 430 440 450
SDAAAAFAGL SREEALRLAL DDVAALHGPV VRQLWDGTGV VKRWAEDQHS
460 470 480 490 500
QGGFVVQPPA LWQTEKDDWT VPYGRIYFAG EHTAYPHGWV ETAVKSALRA
510 520 530 540 550
AIKINSRKGP ASDTASPEGH ASDMEGQGHV HGVASSPSHD LAKEEGSHPP
560
VQGQLSLQNT THTRTSH
Length:567
Mass (Da):62,881
Last modified:December 1, 2001 - v1
Checksum:iFFF953CB28D22F19
GO
Isoform 2 (identifier: Q96RQ9-2) [UniParc]FASTAAdd to basket
Also known as: IL4I1_2

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MAPLA → MPNDDFCPGLTIKAMGAERAPQRQPCT

Note: Uses the promoter of the upstream NUP62 gene and shares the first 2 non-coding exons with NUP62.
Show »
Length:589
Mass (Da):65,328
Checksum:i61FEFA634DF56B49
GO

Sequence cautioni

The sequence BAB84923 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI54291 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI54292 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI54293 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24W → R in AAH64378 (PubMed:15489334).Curated1
Sequence conflicti114A → T in CAI54291 (PubMed:16029492).Curated1
Sequence conflicti114A → T in CAI54293 (PubMed:16029492).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048260501A → S.Corresponds to variant rs2290772dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0171731 – 5MAPLA → MPNDDFCPGLTIKAMGAERA PQRQPCT in isoform 2. 2 Publications5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293462 mRNA. Translation: AAK73362.1.
AF293463 Genomic DNA. Translation: AAK73363.1.
AJ880386 mRNA. Translation: CAI54291.1. Different initiation.
AJ880387 mRNA. Translation: CAI54292.1. Different initiation.
AJ880388 mRNA. Translation: CAI54293.1. Different initiation.
DQ079587 mRNA. Translation: AAZ32711.1.
DQ079588 mRNA. Translation: AAZ32712.1.
DQ079589 mRNA. Translation: AAZ32713.1.
AK074097 mRNA. Translation: BAB84923.1. Different initiation.
AY358933 mRNA. Translation: AAQ89292.1.
CH471177 Genomic DNA. Translation: EAW52575.1.
BC064378 mRNA. Translation: AAH64378.2.
BC090852 mRNA. Translation: AAH90852.2.
CCDSiCCDS12786.1. [Q96RQ9-2]
CCDS12787.1. [Q96RQ9-1]
RefSeqiNP_001244946.1. NM_001258017.1. [Q96RQ9-2]
NP_001244947.1. NM_001258018.1. [Q96RQ9-2]
NP_690863.1. NM_152899.1. [Q96RQ9-1]
NP_758962.1. NM_172374.2. [Q96RQ9-2]
UniGeneiHs.574492.
Hs.741750.

Genome annotation databases

EnsembliENST00000341114; ENSP00000342557; ENSG00000104951. [Q96RQ9-2]
ENST00000391826; ENSP00000375702; ENSG00000104951. [Q96RQ9-1]
ENST00000595948; ENSP00000472474; ENSG00000104951. [Q96RQ9-2]
GeneIDi259307.
KEGGihsa:259307.
UCSCiuc002pqt.2. human. [Q96RQ9-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293462 mRNA. Translation: AAK73362.1.
AF293463 Genomic DNA. Translation: AAK73363.1.
AJ880386 mRNA. Translation: CAI54291.1. Different initiation.
AJ880387 mRNA. Translation: CAI54292.1. Different initiation.
AJ880388 mRNA. Translation: CAI54293.1. Different initiation.
DQ079587 mRNA. Translation: AAZ32711.1.
DQ079588 mRNA. Translation: AAZ32712.1.
DQ079589 mRNA. Translation: AAZ32713.1.
AK074097 mRNA. Translation: BAB84923.1. Different initiation.
AY358933 mRNA. Translation: AAQ89292.1.
CH471177 Genomic DNA. Translation: EAW52575.1.
BC064378 mRNA. Translation: AAH64378.2.
BC090852 mRNA. Translation: AAH90852.2.
CCDSiCCDS12786.1. [Q96RQ9-2]
CCDS12787.1. [Q96RQ9-1]
RefSeqiNP_001244946.1. NM_001258017.1. [Q96RQ9-2]
NP_001244947.1. NM_001258018.1. [Q96RQ9-2]
NP_690863.1. NM_152899.1. [Q96RQ9-1]
NP_758962.1. NM_172374.2. [Q96RQ9-2]
UniGeneiHs.574492.
Hs.741750.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I8Hmodel-@30-504[»]
ProteinModelPortaliQ96RQ9.
SMRiQ96RQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342557.

Chemistry databases

DrugBankiDB03147. Flavin adenine dinucleotide.

PTM databases

iPTMnetiQ96RQ9.
PhosphoSitePlusiQ96RQ9.

Polymorphism and mutation databases

BioMutaiIL4I1.
DMDMi20138284.

Proteomic databases

MaxQBiQ96RQ9.
PaxDbiQ96RQ9.
PeptideAtlasiQ96RQ9.
PRIDEiQ96RQ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341114; ENSP00000342557; ENSG00000104951. [Q96RQ9-2]
ENST00000391826; ENSP00000375702; ENSG00000104951. [Q96RQ9-1]
ENST00000595948; ENSP00000472474; ENSG00000104951. [Q96RQ9-2]
GeneIDi259307.
KEGGihsa:259307.
UCSCiuc002pqt.2. human. [Q96RQ9-1]

Organism-specific databases

CTDi259307.
DisGeNETi259307.
GeneCardsiIL4I1.
HGNCiHGNC:19094. IL4I1.
HPAiHPA045598.
MIMi609742. gene.
neXtProtiNX_Q96RQ9.
OpenTargetsiENSG00000104951.
PharmGKBiPA38795.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEXX. Eukaryota.
COG1231. LUCA.
GeneTreeiENSGT00730000110942.
HOGENOMiHOG000088141.
HOVERGENiHBG005729.
InParanoidiQ96RQ9.
KOiK03334.
OMAiVDPFDSI.
OrthoDBiEOG091G0412.
PhylomeDBiQ96RQ9.
TreeFamiTF313314.

Enzyme and pathway databases

BioCyciZFISH:HS02660-MONOMER.
ReactomeiR-HSA-71182. Phenylalanine and tyrosine catabolism.

Miscellaneous databases

ChiTaRSiIL4I1. human.
GenomeRNAii259307.
PROiQ96RQ9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104951.
ExpressionAtlasiQ96RQ9. baseline and differential.
GenevisibleiQ96RQ9. HS.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiOXLA_HUMAN
AccessioniPrimary (citable) accession number: Q96RQ9
Secondary accession number(s): Q1WMJ3
, Q4GZN1, Q4GZN2, Q6P2Q3, Q8TEM5, Q96RQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.