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Reviewed, UniProtKB/Swiss-Prot Q96RQ9 (OXLA_HUMAN)

Last modified January 19, 2010. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    L-amino-acid oxidase
      Short name=LAAO
      Short name=LAO
    EC=1.4.3.2
Alternative name(s):
    Interleukin-4-induced protein 1
      Short name=IL4-induced protein 1
    Protein Fig-1
      Short name=hFIG1
Gene names
Name: IL4I1
Synonyms: FIG1
ORF Names: UNQ636/PRO1265
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation By similarity.

Catalytic activity

An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.

Cofactor

FAD By similarity.

Subcellular location

Isoform 1: Lysosome By similarity Ref.2.

Isoform 2: Lysosome By similarity Ref.2.

Tissue specificity

Isoform 1 is primarily found in immune tissues. Ref.1

Induction

By interleukin-4.

Sequence similarities

Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

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Ontologies

Keywords
   Cellular componentLysosome
   Coding sequence diversityAlternative promoter usage
Alternative splicing
Polymorphism
   DomainSignal
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionL-amino-acid oxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Alternative products

This entry describes 2 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96RQ9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96RQ9-2)

Also known as: IL4I1_2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MAPLA → MPNDDFCPGLTIKAMGAERAPQRQPCT
Note: Uses the promoter of the upstream NUP62 gene and shares the first 2 non-coding exons with NUP62.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.6
Chain22 – 567546L-amino-acid oxidase
PRO_0000001710

Regions

Nucleotide binding115 – 1162FAD By similarity
Nucleotide binding490 – 4934FAD By similarity

Sites

Binding site891FAD By similarity
Binding site971FAD By similarity
Binding site1161Substrate By similarity
Binding site2871FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding site3981Substrate By similarity
Binding site4811FAD By similarity

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Ref.7
Glycosylation5591N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 199 By similarity

Natural variations

Alternative sequence1 – 55MAPLA → MPNDDFCPGLTIKAMGAERA PQRQPCT in isoform 2.
VSP_017173
Natural variant5011A → S: dbSNP rs2290772.
VAR_048260

Experimental info

Sequence conflict241W → R in AAH64378. Ref.5
Sequence conflict1141A → T in CAI54291. Ref.2
Sequence conflict1141A → T in CAI54293. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: FFF953CB28D22F19

FASTA56762,881
        10         20         30         40         50         60 
MAPLALHLLV LVPILLSLVA SQDWKAERSQ DPFEKCMQDP DYEQLLKVVT WGLNRTLKPQ 

        70         80         90        100        110        120 
RVIVVGAGVA GLVAAKVLSD AGHKVTILEA DNRIGGRIFT YRDQNTGWIG ELGAMRMPSS 

       130        140        150        160        170        180 
HRILHKLCQG LGLNLTKFTQ YDKNTWTEVH EVKLRNYVVE KVPEKLGYAL RPQEKGHSPE 

       190        200        210        220        230        240 
DIYQMALNQA LKDLKALGCR KAMKKFERHT LLEYLLGEGN LSRPAVQLLG DVMSEDGFFY 

       250        260        270        280        290        300 
LSFAEALRAH SCLSDRLQYS RIVGGWDLLP RALLSSLSGL VLLNAPVVAM TQGPHDVHVQ 

       310        320        330        340        350        360 
IETSPPARNL KVLKADVVLL TASGPAVKRI TFSPPLPRHM QEALRRLHYV PATKVFLSFR 

       370        380        390        400        410        420 
RPFWREEHIE GGHSNTDRPS RMIFYPPPRE GALLLASYTW SDAAAAFAGL SREEALRLAL 

       430        440        450        460        470        480 
DDVAALHGPV VRQLWDGTGV VKRWAEDQHS QGGFVVQPPA LWQTEKDDWT VPYGRIYFAG 

       490        500        510        520        530        540 
EHTAYPHGWV ETAVKSALRA AIKINSRKGP ASDTASPEGH ASDMEGQGHV HGVASSPSHD 

       550        560 
LAKEEGSHPP VQGQLSLQNT THTRTSH

« Hide

Isoform 2 (IL4I1_2).

Checksum: 61FEFA634DF56B49
Show »

FASTA58965,328

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References

« Hide 'large scale' references
[1]"Characterization of the human homolog of the IL-4 induced gene-1 (Fig1)."
Chavan S.S., Tian W., Hsueh K., Jawaheer D., Gregersen P.K., Chu C.C.
Biochim. Biophys. Acta 1576:70-80(2002) [PubMed: 12031486] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"Alternative pre-mRNA processing regulates cell-type specific expression of the IL4l1 and NUP62 genes."
Wiemann S., Kolb-Kokocinski A., Poustka A.
BMC Biol. 3:16-16(2005) [PubMed: 16029492] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE PROMOTER USAGE, SUBCELLULAR LOCATION.
[3]"The nucleotide sequence of a long cDNA clone isolated from human spleen."
Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Spleen.
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Ovary and PNS.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-36.
[7]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-220, MASS SPECTROMETRY.
Tissue: Liver.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF293462 mRNA. Translation: AAK73362.1.
AF293463 Genomic DNA. Translation: AAK73363.1.
AJ880386 mRNA. Translation: CAI54291.1. Different initiation.
AJ880387 mRNA. Translation: CAI54292.1. Different initiation.
AJ880388 mRNA. Translation: CAI54293.1. Different initiation.
AK074097 mRNA. Translation: BAB84923.1. Different initiation.
AY358933 mRNA. Translation: AAQ89292.1.
BC064378 mRNA. Translation: AAH64378.2.
BC090852 mRNA. Translation: AAH90852.2.
IPIIPI00045464.
IPI00414928.
RefSeqNP_690863.1.
NP_758962.1.
UniGeneHs.574492

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2I8Hmodel-@30-504[»]
SMRQ96RQ9. Positions 31-508.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ96RQ9.

Proteomic databases

PRIDEQ96RQ9.

Genome annotation databases

EnsemblENST00000319225; ENSP00000321866; ENSG00000104951; Homo sapiens. [Genome view]
ENST00000391826; ENSP00000375702; ENSG00000104951; Homo sapiens. [Genome view]
GeneID259307.
KEGGhsa:259307.
UCSCuc002pqt.1. human.
uc002pqu.1. human.

Organism-specific databases

CTD259307.
GeneCardsGC19M055100.
H-InvDBHIX0015349.
HIX0080120.
HGNCHGNC:19094. IL4I1.
MIM609742. gene.
PharmGKBPA38795.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ96RQ9.
OMAHYMPATK.

Enzyme and pathway databases

BRENDA1.4.3.2. 247.

Gene expression databases

ArrayExpressQ96RQ9.
BgeeQ96RQ9.
GenevestigatorQ96RQ9.
GermOnlineENSG00000104951. Homo sapiens.

Family and domain databases

InterProIPR001613. Amineoxid_fl.
IPR002937. Amino_oxidase.
[Graphical view]
PfamPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSPR00757. AMINEOXDASEF.
ProtoNetSearch...

Other Resources

NextBio93149.
SOURCESearch...

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Entry information

Entry nameOXLA_HUMAN
AccessionPrimary (citable) accession number: Q96RQ9
Secondary accession number(s): Q4GZN1 expand/collapse secondary AC list , Q4GZN2, Q6P2Q3, Q8TEM5, Q96RQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: January 19, 2010
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents