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Q96RQ9 (OXLA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-amino-acid oxidase

Short name=LAAO
Short name=LAO
EC=1.4.3.2
Alternative name(s):
Interleukin-4-induced protein 1
Short name=IL4-induced protein 1
Protein Fig-1
Short name=hFIG1
Gene names
Name:IL4I1
Synonyms:FIG1
ORF Names:UNQ636/PRO1265
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation By similarity.

Catalytic activity

An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.

Cofactor

FAD By similarity.

Subcellular location

Isoform 1: Lysosome By similarity Ref.2.

Isoform 2: Lysosome By similarity Ref.2.

Tissue specificity

Isoform 1 is primarily found in immune tissues. Ref.1

Induction

By IL4/interleukin-4.

Sequence similarities

Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Sequence caution

The sequence BAB84923.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI54291.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI54292.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI54293.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentLysosome
   Coding sequence diversityAlternative promoter usage
Alternative splicing
Polymorphism
   DomainSignal
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

lysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-amino-acid oxidase activity

Inferred from experiment. Source: Reactome

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96RQ9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96RQ9-2)

Also known as: IL4I1_2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MAPLA → MPNDDFCPGLTIKAMGAERAPQRQPCT
Note: Uses the promoter of the upstream NUP62 gene and shares the first 2 non-coding exons with NUP62.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.8
Chain22 – 567546L-amino-acid oxidase
PRO_0000001710

Regions

Nucleotide binding115 – 1162FAD By similarity
Nucleotide binding490 – 4934FAD By similarity

Sites

Binding site891FAD By similarity
Binding site971FAD By similarity
Binding site1161Substrate By similarity
Binding site2871FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding site3981Substrate By similarity
Binding site4811FAD By similarity

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Ref.9
Glycosylation5591N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 199 By similarity

Natural variations

Alternative sequence1 – 55MAPLA → MPNDDFCPGLTIKAMGAERA PQRQPCT in isoform 2.
VSP_017173
Natural variant5011A → S.
Corresponds to variant rs2290772 [ dbSNP | Ensembl ].
VAR_048260

Experimental info

Sequence conflict241W → R in AAH64378. Ref.7
Sequence conflict1141A → T in CAI54291. Ref.2
Sequence conflict1141A → T in CAI54293. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: FFF953CB28D22F19

FASTA56762,881
        10         20         30         40         50         60 
MAPLALHLLV LVPILLSLVA SQDWKAERSQ DPFEKCMQDP DYEQLLKVVT WGLNRTLKPQ 

        70         80         90        100        110        120 
RVIVVGAGVA GLVAAKVLSD AGHKVTILEA DNRIGGRIFT YRDQNTGWIG ELGAMRMPSS 

       130        140        150        160        170        180 
HRILHKLCQG LGLNLTKFTQ YDKNTWTEVH EVKLRNYVVE KVPEKLGYAL RPQEKGHSPE 

       190        200        210        220        230        240 
DIYQMALNQA LKDLKALGCR KAMKKFERHT LLEYLLGEGN LSRPAVQLLG DVMSEDGFFY 

       250        260        270        280        290        300 
LSFAEALRAH SCLSDRLQYS RIVGGWDLLP RALLSSLSGL VLLNAPVVAM TQGPHDVHVQ 

       310        320        330        340        350        360 
IETSPPARNL KVLKADVVLL TASGPAVKRI TFSPPLPRHM QEALRRLHYV PATKVFLSFR 

       370        380        390        400        410        420 
RPFWREEHIE GGHSNTDRPS RMIFYPPPRE GALLLASYTW SDAAAAFAGL SREEALRLAL 

       430        440        450        460        470        480 
DDVAALHGPV VRQLWDGTGV VKRWAEDQHS QGGFVVQPPA LWQTEKDDWT VPYGRIYFAG 

       490        500        510        520        530        540 
EHTAYPHGWV ETAVKSALRA AIKINSRKGP ASDTASPEGH ASDMEGQGHV HGVASSPSHD 

       550        560 
LAKEEGSHPP VQGQLSLQNT THTRTSH 

« Hide

Isoform 2 (IL4I1_2) [UniParc].

Checksum: 61FEFA634DF56B49
Show »

FASTA58965,328

References

« Hide 'large scale' references
[1]"Characterization of the human homolog of the IL-4 induced gene-1 (Fig1)."
Chavan S.S., Tian W., Hsueh K., Jawaheer D., Gregersen P.K., Chu C.C.
Biochim. Biophys. Acta 1576:70-80(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"Alternative pre-mRNA processing regulates cell-type specific expression of the IL4l1 and NUP62 genes."
Wiemann S., Kolb-Kokocinski A., Poustka A.
BMC Biol. 3:16-16(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE PROMOTER USAGE, SUBCELLULAR LOCATION.
[3]"Interleukin-4 induced gene-1 variant (IL4I1_v2) is expressed during spermatogenesis and is decreased in pathologies with hypospermatogenesis."
Chu C.C., Reese S.T., George J., Tian W., Yuan L., Millan C., Marmar J.L., Benoff S.
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Testis.
[4]"The nucleotide sequence of a long cDNA clone isolated from human spleen."
Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Spleen.
[5]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Ovary and PNS.
[8]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-36.
[9]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-220.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF293462 mRNA. Translation: AAK73362.1.
AF293463 Genomic DNA. Translation: AAK73363.1.
AJ880386 mRNA. Translation: CAI54291.1. Different initiation.
AJ880387 mRNA. Translation: CAI54292.1. Different initiation.
AJ880388 mRNA. Translation: CAI54293.1. Different initiation.
DQ079587 mRNA. Translation: AAZ32711.1.
DQ079588 mRNA. Translation: AAZ32712.1.
DQ079589 mRNA. Translation: AAZ32713.1.
AK074097 mRNA. Translation: BAB84923.1. Different initiation.
AY358933 mRNA. Translation: AAQ89292.1.
CH471177 Genomic DNA. Translation: EAW52575.1.
BC064378 mRNA. Translation: AAH64378.2.
BC090852 mRNA. Translation: AAH90852.2.
RefSeqNP_001244946.1. NM_001258017.1.
NP_001244947.1. NM_001258018.1.
NP_690863.1. NM_152899.1.
NP_758962.1. NM_172374.2.
UniGeneHs.574492.
Hs.741750.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2I8Hmodel-@30-504[»]
ProteinModelPortalQ96RQ9.
SMRQ96RQ9. Positions 13-543.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129252. 1 interaction.
STRING9606.ENSP00000342557.

PTM databases

PhosphoSiteQ96RQ9.

Polymorphism databases

DMDM20138284.

Proteomic databases

PaxDbQ96RQ9.
PRIDEQ96RQ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341114; ENSP00000342557; ENSG00000104951. [Q96RQ9-2]
ENST00000391826; ENSP00000375702; ENSG00000104951. [Q96RQ9-1]
ENST00000595948; ENSP00000472474; ENSG00000104951. [Q96RQ9-2]
GeneID259307.
KEGGhsa:259307.
UCSCuc002pqt.1. human. [Q96RQ9-1]
uc002pqu.2. human. [Q96RQ9-2]

Organism-specific databases

CTD259307.
GeneCardsGC19M050392.
HGNCHGNC:19094. IL4I1.
HPACAB020724.
HPA045598.
MIM609742. gene.
neXtProtNX_Q96RQ9.
PharmGKBPA38795.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1231.
HOGENOMHOG000088141.
HOVERGENHBG005729.
KOK03334.
OMAVDPFDSI.
OrthoDBEOG7NGQB9.
PhylomeDBQ96RQ9.
TreeFamTF313314.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.

Gene expression databases

ArrayExpressQ96RQ9.
BgeeQ96RQ9.
GenevestigatorQ96RQ9.

Family and domain databases

InterProIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSPR00757. AMINEOXDASEF.
ProtoNetSearch...

Other

ChiTaRSIL4I1. human.
GenomeRNAi259307.
NextBio93149.
PROQ96RQ9.
SOURCESearch...

Entry information

Entry nameOXLA_HUMAN
AccessionPrimary (citable) accession number: Q96RQ9
Secondary accession number(s): Q1WMJ3 expand/collapse secondary AC list , Q4GZN1, Q4GZN2, Q6P2Q3, Q8TEM5, Q96RQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM