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Protein

Endoplasmic reticulum-Golgi intermediate compartment protein 2

Gene

ERGIC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible role in transport between endoplasmic reticulum and Golgi.By similarity

GO - Biological processi

  • retrograde vesicle-mediated transport, Golgi to ER Source: WormBase
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum-Golgi intermediate compartment protein 2
Gene namesi
Name:ERGIC2
Synonyms:ERV41, PTX1
ORF Names:CDA14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:30208. ERGIC2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 319LumenalSequence analysisAdd BLAST265
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 377CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51290.
OpenTargetsiENSG00000087502.
PharmGKBiPA143485457.

Polymorphism and mutation databases

BioMutaiERGIC2.
DMDMi108935982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393821 – 377Endoplasmic reticulum-Golgi intermediate compartment protein 2Add BLAST377

Proteomic databases

EPDiQ96RQ1.
MaxQBiQ96RQ1.
PaxDbiQ96RQ1.
PeptideAtlasiQ96RQ1.
PRIDEiQ96RQ1.

PTM databases

iPTMnetiQ96RQ1.
PhosphoSitePlusiQ96RQ1.
SwissPalmiQ96RQ1.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000087502.
CleanExiHS_ERGIC2.
ExpressionAtlasiQ96RQ1. baseline and differential.
GenevisibleiQ96RQ1. HS.

Organism-specific databases

HPAiHPA029222.
HPA049695.

Interactioni

Subunit structurei

May interact with EEF1A1.1 Publication

Protein-protein interaction databases

BioGridi119441. 23 interactors.
IntActiQ96RQ1. 2 interactors.
STRINGi9606.ENSP00000353270.

Structurei

3D structure databases

ProteinModelPortaliQ96RQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2667. Eukaryota.
ENOG410XP7X. LUCA.
GeneTreeiENSGT00530000063113.
HOGENOMiHOG000006759.
HOVERGENiHBG054683.
InParanoidiQ96RQ1.
KOiK20366.
PhylomeDBiQ96RQ1.
TreeFamiTF317192.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLNRKKTL SLVKELDAFP KVPESYVETS ASGGTVSLIA FTTMALLTIM
60 70 80 90 100
EFSVYQDTWM KYEYEVDKDF SSKLRINIDI TVAMKCQYVG ADVLDLAETM
110 120 130 140 150
VASADGLVYE PTVFDLSPQQ KEWQRMLQLI QSRLQEEHSL QDVIFKSAFK
160 170 180 190 200
STSTALPPRE DDSSQSPNAC RIHGHLYVNK VAGNFHITVG KAIPHPRGHA
210 220 230 240 250
HLAALVNHES YNFSHRIDHL SFGELVPAII NPLDGTEKIA IDHNQMFQYF
260 270 280 290 300
ITVVPTKLHT YKISADTHQF SVTERERIIN HAAGSHGVSG IFMKYDLSSL
310 320 330 340 350
MVTVTEEHMP FWQFFVRLCG IVGGIFSTTG MLHGIGKFIV EIICCRFRLG
360 370
SYKPVNSVPF EDGHTDNHLP LLENNTH
Length:377
Mass (Da):42,549
Last modified:June 13, 2006 - v2
Checksum:i3820FA05515634ED
GO

Sequence cautioni

The sequence AAF61208 differs from that shown. Reason: Frameshift at positions 202, 209 and 212.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51E → K in AAK77355 (PubMed:11445006).Curated1
Sequence conflicti266D → Y in AAK77355 (PubMed:11445006).Curated1
Sequence conflicti374N → S in BAD96519 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302767 mRNA. Translation: AAK77355.1.
AK074520 mRNA. Translation: BAC11037.1.
AF216751 mRNA. Translation: AAF61208.1. Frameshift.
AK222799 mRNA. Translation: BAD96519.1.
AC009318 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96592.1.
BC000887 mRNA. Translation: AAH00887.2.
BC107794 mRNA. Translation: AAI07795.1.
CCDSiCCDS41765.1.
RefSeqiNP_057654.2. NM_016570.2.
UniGeneiHs.339453.

Genome annotation databases

EnsembliENST00000360150; ENSP00000353270; ENSG00000087502.
GeneIDi51290.
KEGGihsa:51290.
UCSCiuc001riv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302767 mRNA. Translation: AAK77355.1.
AK074520 mRNA. Translation: BAC11037.1.
AF216751 mRNA. Translation: AAF61208.1. Frameshift.
AK222799 mRNA. Translation: BAD96519.1.
AC009318 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96592.1.
BC000887 mRNA. Translation: AAH00887.2.
BC107794 mRNA. Translation: AAI07795.1.
CCDSiCCDS41765.1.
RefSeqiNP_057654.2. NM_016570.2.
UniGeneiHs.339453.

3D structure databases

ProteinModelPortaliQ96RQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119441. 23 interactors.
IntActiQ96RQ1. 2 interactors.
STRINGi9606.ENSP00000353270.

PTM databases

iPTMnetiQ96RQ1.
PhosphoSitePlusiQ96RQ1.
SwissPalmiQ96RQ1.

Polymorphism and mutation databases

BioMutaiERGIC2.
DMDMi108935982.

Proteomic databases

EPDiQ96RQ1.
MaxQBiQ96RQ1.
PaxDbiQ96RQ1.
PeptideAtlasiQ96RQ1.
PRIDEiQ96RQ1.

Protocols and materials databases

DNASUi51290.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360150; ENSP00000353270; ENSG00000087502.
GeneIDi51290.
KEGGihsa:51290.
UCSCiuc001riv.4. human.

Organism-specific databases

CTDi51290.
DisGeNETi51290.
GeneCardsiERGIC2.
HGNCiHGNC:30208. ERGIC2.
HPAiHPA029222.
HPA049695.
MIMi612236. gene.
neXtProtiNX_Q96RQ1.
OpenTargetsiENSG00000087502.
PharmGKBiPA143485457.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2667. Eukaryota.
ENOG410XP7X. LUCA.
GeneTreeiENSGT00530000063113.
HOGENOMiHOG000006759.
HOVERGENiHBG054683.
InParanoidiQ96RQ1.
KOiK20366.
PhylomeDBiQ96RQ1.
TreeFamiTF317192.

Miscellaneous databases

GeneWikiiERGIC2.
GenomeRNAii51290.
PROiQ96RQ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000087502.
CleanExiHS_ERGIC2.
ExpressionAtlasiQ96RQ1. baseline and differential.
GenevisibleiQ96RQ1. HS.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERGI2_HUMAN
AccessioniPrimary (citable) accession number: Q96RQ1
Secondary accession number(s): A6NHH6
, Q53GY2, Q8N2Q9, Q9BVV9, Q9NZA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.