Q96RP8 (KCNA7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily A member 7

Alternative name(s):
Voltage-gated potassium channel subunit Kv1.7

Gene names

Name:

KCNA7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient By similarity.
Subunit structure	Heterotetramer of potassium channel proteins By similarity.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Highly expressed in skeletal muscle, heart and kidney. Ref.1 Ref.2
Domain	The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments By similarity. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.
Sequence similarities	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	plasma membrane Traceable author statement. Source: Reactome voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Potassium voltage-gated channel subfamily A member 7		PRO_0000308273
Regions
	Transmembrane	144 – 164	21	Helical; Name=Segment S1; Potential
	Transmembrane	209 – 229	21	Helical; Name=Segment S2; Potential
	Transmembrane	241 – 261	21	Helical; Name=Segment S3; Potential
	Transmembrane	276 – 295	20	Helical; Voltage-sensor; Name=Segment S4; Potential
	Transmembrane	312 – 332	21	Helical; Name=Segment S5; Potential
	Transmembrane	373 – 393	21	Helical; Name=Segment S6; Potential
	Motif	358 – 363	6	Selectivity filter By similarity
Amino acid modifications
	Lipidation	231	1	S-palmitoyl cysteine Potential
	Glycosylation	191	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	189	1	P → R. Ref.2 Ref.3 Corresponds to variant rs1611775 [ dbSNP | Ensembl ].		VAR_036776
	Natural variant	418	1	M → T. Ref.1 Ref.2 Corresponds to variant rs1017219 [ dbSNP | Ensembl ].		VAR_036777
Experimental info
	Sequence conflict	71	1	Y → H in AAX11186. Ref.3
	Sequence conflict	180	1	A → V in AAX11186. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q96RP8 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: EF9980CF54D52FB8	FASTA	456	50,559
	10 20 30 40 50 60 MEPRCPPPCG CCERLVLNVA GLRFETRART LGRFPDTLLG DPARRGRFYD DARREYFFDR 70 80 90 100 110 120 HRPSFDAVLY YYQSGGRLRR PAHVPLDVFL EEVAFYGLGA AALARLREDE GCPVPPERPL 130 140 150 160 170 180 PRRAFARQLW LLFEFPESSQ AARVLAVVSV LVILVSIVVF CLETLPDFRD DRDGTGLAAA 190 200 210 220 230 240 AAAGPFPAPL NGSSQMPGNP PRLPFNDPFF VVETLCICWF SFELLVRLLV CPSKAIFFKN 250 260 270 280 290 300 VMNLIDFVAI LPYFVALGTE LARQRGVGQQ AMSLAILRVI RLVRVFRIFK LSRHSKGLQI 310 320 330 340 350 360 LGQTLRASMR ELGLLIFFLF IGVVLFSSAV YFAEVDRVDS HFTSIPESFW WAVVTMTTVG 370 380 390 400 410 420 YGDMAPVTVG GKIVGSLCAI AGVLTISLPV PVIVSNFSYF YHRETEGEEA GMFSHVDMQP 430 440 450 CGPLEGKANG GLVDGEVPEL PPPLWAPPGK HLVTEV

References

[1]	"Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family." Kashuba V.I., Kvasha S.M., Protopopov A.I., Gizatullin R.Z., Rynditch A.V., Wahlestedt C., Wasserman W.W., Zabarovsky E.R. Gene 268:115-122(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-418, TISSUE SPECIFICITY. Tissue: Heart.
[2]	"Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI)." Bardien-Kruger S., Wulff H., Arieff Z., Brink P., Chandy K.G., Corfield V. Eur. J. Hum. Genet. 10:36-43(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-189 AND THR-418, TISSUE SPECIFICITY.
[3]	Finol-Urdaneta R.K., Struever N., Terlau H. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-189. Tissue: Heart muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ310479 mRNA. Translation: CAC29065.1. AF315818 mRNA. Translation: AAK63002.1. AY779768 mRNA. Translation: AAX11186.1.
IPI	IPI00170531.
RefSeq	NP_114092.2. NM_031886.2.
UniGene	Hs.306973.
3D structure databases
ProteinModelPortal	Q96RP8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000221444.
Polymorphism databases
DMDM	74752109.
Proteomic databases
PaxDb	Q96RP8.
PRIDE	Q96RP8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000221444; ENSP00000221444; ENSG00000104848.
GeneID	3743.
KEGG	hsa:3743.
UCSC	uc002pmg.3. human.
Organism-specific databases
CTD	3743.
GeneCards	GC19M049570.
HGNC	HGNC:6226. KCNA7.
MIM	176268. gene.
neXtProt	NX_Q96RP8.
PharmGKB	PA30023.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1226.
HOGENOM	HOG000231015.
HOVERGEN	HBG052230.
InParanoid	Q96RP8.
KO	K04880.
OMA	FDDPFFV.
OrthoDB	EOG4QC155.
PhylomeDB	Q96RP8.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
Bgee	Q96RP8.
CleanEx	HS_KCNA7.
Genevestigator	Q96RP8.
Family and domain databases
Gene3D	1.20.120.350. 1 hit. 3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR027359. K_channel_four-helix_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003972. K_chnl_volt-dep_Kv1. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01491. KVCHANNEL. PR01496. SHAKERCHANEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
BindingDB	Q96RP8.
ChEMBL	CHEMBL2773.
GenomeRNAi	3743.
NextBio	14647.
SOURCE	Search...

Entry information

Entry name

KCNA7_HUMAN

Accession

Primary (citable) accession number: Q96RP8
Secondary accession number(s): A1KYX7, Q9BYS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	December 1, 2001
Last modified:	May 29, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.