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Protein

Potassium voltage-gated channel subfamily A member 7

Gene

KCNA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).By similarity

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: GO_Central

GO - Biological processi

  1. potassium ion transmembrane transport Source: GO_Central
  2. protein homooligomerization Source: InterPro
  3. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 7
Alternative name(s):
Voltage-gated potassium channel subunit Kv1.7
Gene namesi
Name:KCNA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6226. KCNA7.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei144 – 16421Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei276 – 29520Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei312 – 33221Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei373 – 39321Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: Reactome
  3. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30023.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Potassium voltage-gated channel subfamily A member 7PRO_0000308273Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
Lipidationi231 – 2311S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ96RP8.
PRIDEiQ96RP8.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle, heart and kidney.2 Publications

Gene expression databases

BgeeiQ96RP8.
CleanExiHS_KCNA7.
GenevestigatoriQ96RP8.

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000221444.

Structurei

3D structure databases

ProteinModelPortaliQ96RP8.
SMRiQ96RP8. Positions 12-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi358 – 3636Selectivity filterBy similarity

Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.By similarity
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiQ96RP8.
KOiK04880.
OMAiAMEPRCP.
OrthoDBiEOG7M0NRD.
PhylomeDBiQ96RP8.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96RP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPRCPPPCG CCERLVLNVA GLRFETRART LGRFPDTLLG DPARRGRFYD
60 70 80 90 100
DARREYFFDR HRPSFDAVLY YYQSGGRLRR PAHVPLDVFL EEVAFYGLGA
110 120 130 140 150
AALARLREDE GCPVPPERPL PRRAFARQLW LLFEFPESSQ AARVLAVVSV
160 170 180 190 200
LVILVSIVVF CLETLPDFRD DRDGTGLAAA AAAGPFPAPL NGSSQMPGNP
210 220 230 240 250
PRLPFNDPFF VVETLCICWF SFELLVRLLV CPSKAIFFKN VMNLIDFVAI
260 270 280 290 300
LPYFVALGTE LARQRGVGQQ AMSLAILRVI RLVRVFRIFK LSRHSKGLQI
310 320 330 340 350
LGQTLRASMR ELGLLIFFLF IGVVLFSSAV YFAEVDRVDS HFTSIPESFW
360 370 380 390 400
WAVVTMTTVG YGDMAPVTVG GKIVGSLCAI AGVLTISLPV PVIVSNFSYF
410 420 430 440 450
YHRETEGEEA GMFSHVDMQP CGPLEGKANG GLVDGEVPEL PPPLWAPPGK

HLVTEV
Length:456
Mass (Da):50,559
Last modified:December 1, 2001 - v1
Checksum:iEF9980CF54D52FB8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711Y → H in AAX11186 (Ref. 3) Curated
Sequence conflicti180 – 1801A → V in AAX11186 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti189 – 1891P → R.2 Publications
Corresponds to variant rs1611775 [ dbSNP | Ensembl ].
VAR_036776
Natural varianti418 – 4181M → T.2 Publications
Corresponds to variant rs1017219 [ dbSNP | Ensembl ].
VAR_036777

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310479 mRNA. Translation: CAC29065.1.
AF315818 mRNA. Translation: AAK63002.1.
AY779768 mRNA. Translation: AAX11186.1.
CCDSiCCDS12755.1.
RefSeqiNP_114092.2. NM_031886.2.
UniGeneiHs.306973.

Genome annotation databases

EnsembliENST00000221444; ENSP00000221444; ENSG00000104848.
GeneIDi3743.
KEGGihsa:3743.
UCSCiuc002pmg.3. human.

Polymorphism databases

DMDMi74752109.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310479 mRNA. Translation: CAC29065.1.
AF315818 mRNA. Translation: AAK63002.1.
AY779768 mRNA. Translation: AAX11186.1.
CCDSiCCDS12755.1.
RefSeqiNP_114092.2. NM_031886.2.
UniGeneiHs.306973.

3D structure databases

ProteinModelPortaliQ96RP8.
SMRiQ96RP8. Positions 12-405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000221444.

Chemistry

ChEMBLiCHEMBL2362996.
DrugBankiDB06637. Dalfampridine.
GuidetoPHARMACOLOGYi544.

Polymorphism databases

DMDMi74752109.

Proteomic databases

PaxDbiQ96RP8.
PRIDEiQ96RP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221444; ENSP00000221444; ENSG00000104848.
GeneIDi3743.
KEGGihsa:3743.
UCSCiuc002pmg.3. human.

Organism-specific databases

CTDi3743.
GeneCardsiGC19M049570.
HGNCiHGNC:6226. KCNA7.
MIMi176268. gene.
neXtProtiNX_Q96RP8.
PharmGKBiPA30023.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiQ96RP8.
KOiK04880.
OMAiAMEPRCP.
OrthoDBiEOG7M0NRD.
PhylomeDBiQ96RP8.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikiiKCNA7.
GenomeRNAii3743.
NextBioi14647.
PROiQ96RP8.
SOURCEiSearch...

Gene expression databases

BgeeiQ96RP8.
CleanExiHS_KCNA7.
GenevestigatoriQ96RP8.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family."
    Kashuba V.I., Kvasha S.M., Protopopov A.I., Gizatullin R.Z., Rynditch A.V., Wahlestedt C., Wasserman W.W., Zabarovsky E.R.
    Gene 268:115-122(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-418, TISSUE SPECIFICITY.
    Tissue: Heart.
  2. "Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI)."
    Bardien-Kruger S., Wulff H., Arieff Z., Brink P., Chandy K.G., Corfield V.
    Eur. J. Hum. Genet. 10:36-43(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-189 AND THR-418, TISSUE SPECIFICITY.
  3. Finol-Urdaneta R.K., Struever N., Terlau H.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-189.
    Tissue: Heart muscle.

Entry informationi

Entry nameiKCNA7_HUMAN
AccessioniPrimary (citable) accession number: Q96RP8
Secondary accession number(s): A1KYX7, Q9BYS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 1, 2001
Last modified: March 4, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.