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Q96RP8 (KCNA7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily A member 7
Alternative name(s):
Voltage-gated potassium channel subunit Kv1.7
Gene names
Name:KCNA7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient By similarity.

Subunit structure

Heterotetramer of potassium channel proteins By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Highly expressed in skeletal muscle, heart and kidney. Ref.1 Ref.2

Domain

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments By similarity.

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.

Sequence similarities

Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 456456Potassium voltage-gated channel subfamily A member 7
PRO_0000308273

Regions

Transmembrane144 – 16421Helical; Name=Segment S1; Potential
Transmembrane209 – 22921Helical; Name=Segment S2; Potential
Transmembrane241 – 26121Helical; Name=Segment S3; Potential
Transmembrane276 – 29520Helical; Voltage-sensor; Name=Segment S4; Potential
Transmembrane312 – 33221Helical; Name=Segment S5; Potential
Transmembrane373 – 39321Helical; Name=Segment S6; Potential
Motif358 – 3636Selectivity filter By similarity

Amino acid modifications

Lipidation2311S-palmitoyl cysteine Potential
Glycosylation1911N-linked (GlcNAc...) Potential

Natural variations

Natural variant1891P → R. Ref.2 Ref.3
Corresponds to variant rs1611775 [ dbSNP | Ensembl ].
VAR_036776
Natural variant4181M → T. Ref.1 Ref.2
Corresponds to variant rs1017219 [ dbSNP | Ensembl ].
VAR_036777

Experimental info

Sequence conflict711Y → H in AAX11186. Ref.3
Sequence conflict1801A → V in AAX11186. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q96RP8 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: EF9980CF54D52FB8

FASTA45650,559
        10         20         30         40         50         60 
MEPRCPPPCG CCERLVLNVA GLRFETRART LGRFPDTLLG DPARRGRFYD DARREYFFDR 

        70         80         90        100        110        120 
HRPSFDAVLY YYQSGGRLRR PAHVPLDVFL EEVAFYGLGA AALARLREDE GCPVPPERPL 

       130        140        150        160        170        180 
PRRAFARQLW LLFEFPESSQ AARVLAVVSV LVILVSIVVF CLETLPDFRD DRDGTGLAAA 

       190        200        210        220        230        240 
AAAGPFPAPL NGSSQMPGNP PRLPFNDPFF VVETLCICWF SFELLVRLLV CPSKAIFFKN 

       250        260        270        280        290        300 
VMNLIDFVAI LPYFVALGTE LARQRGVGQQ AMSLAILRVI RLVRVFRIFK LSRHSKGLQI 

       310        320        330        340        350        360 
LGQTLRASMR ELGLLIFFLF IGVVLFSSAV YFAEVDRVDS HFTSIPESFW WAVVTMTTVG 

       370        380        390        400        410        420 
YGDMAPVTVG GKIVGSLCAI AGVLTISLPV PVIVSNFSYF YHRETEGEEA GMFSHVDMQP 

       430        440        450 
CGPLEGKANG GLVDGEVPEL PPPLWAPPGK HLVTEV 

« Hide

References

[1]"Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family."
Kashuba V.I., Kvasha S.M., Protopopov A.I., Gizatullin R.Z., Rynditch A.V., Wahlestedt C., Wasserman W.W., Zabarovsky E.R.
Gene 268:115-122(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-418, TISSUE SPECIFICITY.
Tissue: Heart.
[2]"Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI)."
Bardien-Kruger S., Wulff H., Arieff Z., Brink P., Chandy K.G., Corfield V.
Eur. J. Hum. Genet. 10:36-43(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-189 AND THR-418, TISSUE SPECIFICITY.
[3]Finol-Urdaneta R.K., Struever N., Terlau H.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-189.
Tissue: Heart muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ310479 mRNA. Translation: CAC29065.1.
AF315818 mRNA. Translation: AAK63002.1.
AY779768 mRNA. Translation: AAX11186.1.
CCDSCCDS12755.1.
RefSeqNP_114092.2. NM_031886.2.
UniGeneHs.306973.

3D structure databases

ProteinModelPortalQ96RP8.
SMRQ96RP8. Positions 12-405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000221444.

Chemistry

BindingDBQ96RP8.
ChEMBLCHEMBL2362996.
GuidetoPHARMACOLOGY544.

Polymorphism databases

DMDM74752109.

Proteomic databases

PaxDbQ96RP8.
PRIDEQ96RP8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221444; ENSP00000221444; ENSG00000104848.
GeneID3743.
KEGGhsa:3743.
UCSCuc002pmg.3. human.

Organism-specific databases

CTD3743.
GeneCardsGC19M049570.
HGNCHGNC:6226. KCNA7.
HPAHPA060229.
MIM176268. gene.
neXtProtNX_Q96RP8.
PharmGKBPA30023.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000231015.
HOVERGENHBG052230.
InParanoidQ96RP8.
KOK04880.
OMAAMEPRCP.
OrthoDBEOG7M0NRD.
PhylomeDBQ96RP8.
TreeFamTF313103.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

BgeeQ96RP8.
CleanExHS_KCNA7.
GenevestigatorQ96RP8.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

GeneWikiKCNA7.
GenomeRNAi3743.
NextBio14647.
PROQ96RP8.
SOURCESearch...

Entry information

Entry nameKCNA7_HUMAN
AccessionPrimary (citable) accession number: Q96RP8
Secondary accession number(s): A1KYX7, Q9BYS4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM