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Q96RP8

- KCNA7_HUMAN

UniProt

Q96RP8 - KCNA7_HUMAN

Protein

Potassium voltage-gated channel subfamily A member 7

Gene

KCNA7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient By similarity.By similarity

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. protein homooligomerization Source: InterPro
    2. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily A member 7
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv1.7
    Gene namesi
    Name:KCNA7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6226. KCNA7.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. plasma membrane Source: Reactome
    2. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30023.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456Potassium voltage-gated channel subfamily A member 7PRO_0000308273Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
    Lipidationi231 – 2311S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ96RP8.
    PRIDEiQ96RP8.

    Expressioni

    Tissue specificityi

    Highly expressed in skeletal muscle, heart and kidney.2 Publications

    Gene expression databases

    BgeeiQ96RP8.
    CleanExiHS_KCNA7.
    GenevestigatoriQ96RP8.

    Organism-specific databases

    HPAiHPA060229.

    Interactioni

    Subunit structurei

    Heterotetramer of potassium channel proteins.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000221444.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96RP8.
    SMRiQ96RP8. Positions 12-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei144 – 16421Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29520Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei312 – 33221Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei373 – 39321Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi358 – 3636Selectivity filterBy similarity

    Domaini

    The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.By similarity
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231015.
    HOVERGENiHBG052230.
    InParanoidiQ96RP8.
    KOiK04880.
    OMAiAMEPRCP.
    OrthoDBiEOG7M0NRD.
    PhylomeDBiQ96RP8.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003972. K_chnl_volt-dep_Kv1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01491. KVCHANNEL.
    PR01496. SHAKERCHANEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96RP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPRCPPPCG CCERLVLNVA GLRFETRART LGRFPDTLLG DPARRGRFYD    50
    DARREYFFDR HRPSFDAVLY YYQSGGRLRR PAHVPLDVFL EEVAFYGLGA 100
    AALARLREDE GCPVPPERPL PRRAFARQLW LLFEFPESSQ AARVLAVVSV 150
    LVILVSIVVF CLETLPDFRD DRDGTGLAAA AAAGPFPAPL NGSSQMPGNP 200
    PRLPFNDPFF VVETLCICWF SFELLVRLLV CPSKAIFFKN VMNLIDFVAI 250
    LPYFVALGTE LARQRGVGQQ AMSLAILRVI RLVRVFRIFK LSRHSKGLQI 300
    LGQTLRASMR ELGLLIFFLF IGVVLFSSAV YFAEVDRVDS HFTSIPESFW 350
    WAVVTMTTVG YGDMAPVTVG GKIVGSLCAI AGVLTISLPV PVIVSNFSYF 400
    YHRETEGEEA GMFSHVDMQP CGPLEGKANG GLVDGEVPEL PPPLWAPPGK 450
    HLVTEV 456
    Length:456
    Mass (Da):50,559
    Last modified:December 1, 2001 - v1
    Checksum:iEF9980CF54D52FB8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti71 – 711Y → H in AAX11186. 1 PublicationCurated
    Sequence conflicti180 – 1801A → V in AAX11186. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti189 – 1891P → R.2 Publications
    Corresponds to variant rs1611775 [ dbSNP | Ensembl ].
    VAR_036776
    Natural varianti418 – 4181M → T.2 Publications
    Corresponds to variant rs1017219 [ dbSNP | Ensembl ].
    VAR_036777

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ310479 mRNA. Translation: CAC29065.1.
    AF315818 mRNA. Translation: AAK63002.1.
    AY779768 mRNA. Translation: AAX11186.1.
    CCDSiCCDS12755.1.
    RefSeqiNP_114092.2. NM_031886.2.
    UniGeneiHs.306973.

    Genome annotation databases

    EnsembliENST00000221444; ENSP00000221444; ENSG00000104848.
    GeneIDi3743.
    KEGGihsa:3743.
    UCSCiuc002pmg.3. human.

    Polymorphism databases

    DMDMi74752109.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ310479 mRNA. Translation: CAC29065.1 .
    AF315818 mRNA. Translation: AAK63002.1 .
    AY779768 mRNA. Translation: AAX11186.1 .
    CCDSi CCDS12755.1.
    RefSeqi NP_114092.2. NM_031886.2.
    UniGenei Hs.306973.

    3D structure databases

    ProteinModelPortali Q96RP8.
    SMRi Q96RP8. Positions 12-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000221444.

    Chemistry

    BindingDBi Q96RP8.
    ChEMBLi CHEMBL2362996.
    GuidetoPHARMACOLOGYi 544.

    Polymorphism databases

    DMDMi 74752109.

    Proteomic databases

    PaxDbi Q96RP8.
    PRIDEi Q96RP8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221444 ; ENSP00000221444 ; ENSG00000104848 .
    GeneIDi 3743.
    KEGGi hsa:3743.
    UCSCi uc002pmg.3. human.

    Organism-specific databases

    CTDi 3743.
    GeneCardsi GC19M049570.
    HGNCi HGNC:6226. KCNA7.
    HPAi HPA060229.
    MIMi 176268. gene.
    neXtProti NX_Q96RP8.
    PharmGKBi PA30023.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231015.
    HOVERGENi HBG052230.
    InParanoidi Q96RP8.
    KOi K04880.
    OMAi AMEPRCP.
    OrthoDBi EOG7M0NRD.
    PhylomeDBi Q96RP8.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNA7.
    GenomeRNAii 3743.
    NextBioi 14647.
    PROi Q96RP8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96RP8.
    CleanExi HS_KCNA7.
    Genevestigatori Q96RP8.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003972. K_chnl_volt-dep_Kv1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01491. KVCHANNEL.
    PR01496. SHAKERCHANEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family."
      Kashuba V.I., Kvasha S.M., Protopopov A.I., Gizatullin R.Z., Rynditch A.V., Wahlestedt C., Wasserman W.W., Zabarovsky E.R.
      Gene 268:115-122(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-418, TISSUE SPECIFICITY.
      Tissue: Heart.
    2. "Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI)."
      Bardien-Kruger S., Wulff H., Arieff Z., Brink P., Chandy K.G., Corfield V.
      Eur. J. Hum. Genet. 10:36-43(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-189 AND THR-418, TISSUE SPECIFICITY.
    3. Finol-Urdaneta R.K., Struever N., Terlau H.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-189.
      Tissue: Heart muscle.

    Entry informationi

    Entry nameiKCNA7_HUMAN
    AccessioniPrimary (citable) accession number: Q96RP8
    Secondary accession number(s): A1KYX7, Q9BYS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3