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Q96RP7

- G3ST4_HUMAN

UniProt

Q96RP7 - G3ST4_HUMAN

Protein

Galactose-3-O-sulfotransferase 4

Gene

GAL3ST4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc.1 Publication

    Cofactori

    Manganese.

    pH dependencei

    Optimum pH is 6-7.

    Pathwayi

    GO - Molecular functioni

    1. 3'-phosphoadenosine 5'-phosphosulfate binding Source: UniProtKB
    2. galactose 3-O-sulfotransferase activity Source: UniProtKB
    3. galactosylceramide sulfotransferase activity Source: InterPro
    4. proteoglycan sulfotransferase activity Source: UniProtKB

    GO - Biological processi

    1. cell-cell signaling Source: UniProtKB
    2. glycoprotein metabolic process Source: UniProtKB
    3. oligosaccharide metabolic process Source: UniProtKB
    4. proteoglycan biosynthetic process Source: UniProtKB
    5. sulfur compound metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00353.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galactose-3-O-sulfotransferase 4 (EC:2.8.2.-)
    Short name:
    Gal3ST-4
    Alternative name(s):
    Beta-galactose-3-O-sulfotransferase 4
    Gal-beta-1,3-GalNAc 3'-sulfotransferase
    Gene namesi
    Name:GAL3ST4
    ORF Names:PP6968
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:24145. GAL3ST4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. Golgi cisterna membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB
    4. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134921067.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Galactose-3-O-sulfotransferase 4PRO_0000085209Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ96RP7.
    PRIDEiQ96RP7.

    PTM databases

    PhosphoSiteiQ96RP7.

    Expressioni

    Tissue specificityi

    Expressed mainly in placenta, thymus, testis, ovary, spinal cord, trachea and adrenal gland and at low levels in brain, lung, spleen, prostate, small intestine, colon, stomach thyroid and lymph node.1 Publication

    Gene expression databases

    ArrayExpressiQ96RP7.
    BgeeiQ96RP7.
    CleanExiHS_GAL3ST4.
    GenevestigatoriQ96RP7.

    Organism-specific databases

    HPAiHPA038137.

    Interactioni

    Protein-protein interaction databases

    BioGridi122811. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96RP7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini40 – 486447LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26344.
    HOVERGENiHBG051681.
    InParanoidiQ96RP7.
    KOiK09677.
    OMAiDHYARNL.
    OrthoDBiEOG7K0ZF1.
    PhylomeDBiQ96RP7.
    TreeFamiTF314802.

    Family and domain databases

    InterProiIPR009729. Gal-3-0_sulfotransfrase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR14647. PTHR14647. 1 hit.
    PfamiPF06990. Gal-3-0_sulfotr. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96RP7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPLSPARTL RLWGPRSLGV ALGVFMTIGF ALQLLGGPFQ RRLPGLQLRQ    50
    PSAPSLRPAL PSCPPRQRLV FLKTHKSGSS SVLSLLHRYG DQHGLRFALP 100
    ARYQFGYPKL FQASRVKGYR PQGGGTQLPF HILCHHMRFN LKEVLQVMPS 150
    DSFFFSIVRD PAALARSAFS YYKSTSSAFR KSPSLAAFLA NPRGFYRPGA 200
    RGDHYARNLL WFDFGLPFPP EKRAKRGNIH PPRDPNPPQL QVLPSGAGPR 250
    AQTLNPNALI HPVSTVTDHR SQISSPASFD LGSSSFIQWG LAWLDSVFDL 300
    VMVAEYFDES LVLLADALCW GLDDVVGFMH NAQAGHKQGL STVSNSGLTA 350
    EDRQLTARAR AWNNLDWALY VHFNRSLWAR IEKYGQGRLQ TAVAELRARR 400
    EALAKHCLVG GEASDPKYIT DRRFRPFQFG SAKVLGYILR SGLSPQDQEE 450
    CERLATPELQ YKDKLDAKQF PPTVSLPLKT SRPLSP 486
    Length:486
    Mass (Da):54,166
    Last modified:December 1, 2001 - v1
    Checksum:i2D731D16B191CC3C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti137 – 1371M → L in BAB13977. (PubMed:14702039)Curated
    Sequence conflicti201 – 2044RGDH → VGTT in AAL55759. (PubMed:15498874)Curated
    Sequence conflicti441 – 4411S → R in BAB13977. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti353 – 3531R → Q.
    Corresponds to variant rs3800952 [ dbSNP | Ensembl ].
    VAR_021989
    Natural varianti467 – 4671A → V.2 Publications
    Corresponds to variant rs3823646 [ dbSNP | Ensembl ].
    VAR_033736

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF316113 mRNA. Translation: AAK73365.1.
    AF289575 mRNA. Translation: AAL55759.1.
    AK022178 mRNA. Translation: BAB13977.1.
    AL833824 mRNA. Translation: CAD38686.2.
    CH236956 Genomic DNA. Translation: EAL23847.1.
    CH471091 Genomic DNA. Translation: EAW76575.1.
    CH471091 Genomic DNA. Translation: EAW76577.1.
    CH471091 Genomic DNA. Translation: EAW76579.1.
    BC012976 mRNA. Translation: AAH12976.1.
    CCDSiCCDS5688.1.
    RefSeqiNP_078913.3. NM_024637.4.
    UniGeneiHs.44856.

    Genome annotation databases

    EnsembliENST00000360039; ENSP00000353142; ENSG00000197093.
    ENST00000413800; ENSP00000400451; ENSG00000197093.
    GeneIDi79690.
    KEGGihsa:79690.
    UCSCiuc003utt.3. human.

    Polymorphism databases

    DMDMi47116570.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF316113 mRNA. Translation: AAK73365.1 .
    AF289575 mRNA. Translation: AAL55759.1 .
    AK022178 mRNA. Translation: BAB13977.1 .
    AL833824 mRNA. Translation: CAD38686.2 .
    CH236956 Genomic DNA. Translation: EAL23847.1 .
    CH471091 Genomic DNA. Translation: EAW76575.1 .
    CH471091 Genomic DNA. Translation: EAW76577.1 .
    CH471091 Genomic DNA. Translation: EAW76579.1 .
    BC012976 mRNA. Translation: AAH12976.1 .
    CCDSi CCDS5688.1.
    RefSeqi NP_078913.3. NM_024637.4.
    UniGenei Hs.44856.

    3D structure databases

    ProteinModelPortali Q96RP7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122811. 1 interaction.

    PTM databases

    PhosphoSitei Q96RP7.

    Polymorphism databases

    DMDMi 47116570.

    Proteomic databases

    PaxDbi Q96RP7.
    PRIDEi Q96RP7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360039 ; ENSP00000353142 ; ENSG00000197093 .
    ENST00000413800 ; ENSP00000400451 ; ENSG00000197093 .
    GeneIDi 79690.
    KEGGi hsa:79690.
    UCSCi uc003utt.3. human.

    Organism-specific databases

    CTDi 79690.
    GeneCardsi GC07M099770.
    HGNCi HGNC:24145. GAL3ST4.
    HPAi HPA038137.
    MIMi 608235. gene.
    neXtProti NX_Q96RP7.
    PharmGKBi PA134921067.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26344.
    HOVERGENi HBG051681.
    InParanoidi Q96RP7.
    KOi K09677.
    OMAi DHYARNL.
    OrthoDBi EOG7K0ZF1.
    PhylomeDBi Q96RP7.
    TreeFami TF314802.

    Enzyme and pathway databases

    UniPathwayi UPA00353 .

    Miscellaneous databases

    GeneWikii GAL3ST4.
    GenomeRNAii 79690.
    NextBioi 68960.
    PROi Q96RP7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96RP7.
    Bgeei Q96RP7.
    CleanExi HS_GAL3ST4.
    Genevestigatori Q96RP7.

    Family and domain databases

    InterProi IPR009729. Gal-3-0_sulfotransfrase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR14647. PTHR14647. 1 hit.
    Pfami PF06990. Gal-3-0_sulfotr. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel human galactose 3-O-sulfotransferase that transfers sulfate to Galbeta1->3GalNAc residue in O-glycans."
      Seko A., Hara-Kuge S., Yamashita K.
      J. Biol. Chem. 276:25697-25704(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-467.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    5. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-467.
      Tissue: Placenta.

    Entry informationi

    Entry nameiG3ST4_HUMAN
    AccessioniPrimary (citable) accession number: Q96RP7
    Secondary accession number(s): A4D2A8
    , D6W5U5, Q8N3P7, Q8WZ17, Q96E33, Q9HA78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3