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Q96RP7

- G3ST4_HUMAN

UniProt

Q96RP7 - G3ST4_HUMAN

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Protein
Galactose-3-O-sulfotransferase 4
Gene
GAL3ST4, PP6968
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc.1 Publication

Cofactori

Manganese.

pH dependencei

Optimum pH is 6-7.

Pathwayi

GO - Molecular functioni

  1. 3'-phosphoadenosine 5'-phosphosulfate binding Source: UniProtKB
  2. galactose 3-O-sulfotransferase activity Source: UniProtKB
  3. galactosylceramide sulfotransferase activity Source: InterPro
  4. proteoglycan sulfotransferase activity Source: UniProtKB

GO - Biological processi

  1. cell-cell signaling Source: UniProtKB
  2. glycoprotein metabolic process Source: UniProtKB
  3. oligosaccharide metabolic process Source: UniProtKB
  4. proteoglycan biosynthetic process Source: UniProtKB
  5. sulfur compound metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

UniPathwayiUPA00353.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-3-O-sulfotransferase 4 (EC:2.8.2.-)
Short name:
Gal3ST-4
Alternative name(s):
Beta-galactose-3-O-sulfotransferase 4
Gal-beta-1,3-GalNAc 3'-sulfotransferase
Gene namesi
Name:GAL3ST4
ORF Names:PP6968
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:24145. GAL3ST4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei19 – 3921Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini40 – 486447Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi cisterna membrane Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of membrane Source: UniProtKB
  4. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134921067.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Galactose-3-O-sulfotransferase 4
PRO_0000085209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi374 – 3741N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96RP7.
PRIDEiQ96RP7.

PTM databases

PhosphoSiteiQ96RP7.

Expressioni

Tissue specificityi

Expressed mainly in placenta, thymus, testis, ovary, spinal cord, trachea and adrenal gland and at low levels in brain, lung, spleen, prostate, small intestine, colon, stomach thyroid and lymph node.1 Publication

Gene expression databases

ArrayExpressiQ96RP7.
BgeeiQ96RP7.
CleanExiHS_GAL3ST4.
GenevestigatoriQ96RP7.

Organism-specific databases

HPAiHPA038137.

Interactioni

Protein-protein interaction databases

BioGridi122811. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96RP7.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26344.
HOVERGENiHBG051681.
InParanoidiQ96RP7.
KOiK09677.
OMAiDHYARNL.
OrthoDBiEOG7K0ZF1.
PhylomeDBiQ96RP7.
TreeFamiTF314802.

Family and domain databases

InterProiIPR009729. Gal-3-0_sulfotransfrase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR14647. PTHR14647. 1 hit.
PfamiPF06990. Gal-3-0_sulfotr. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96RP7-1 [UniParc]FASTAAdd to Basket

« Hide

MGPLSPARTL RLWGPRSLGV ALGVFMTIGF ALQLLGGPFQ RRLPGLQLRQ    50
PSAPSLRPAL PSCPPRQRLV FLKTHKSGSS SVLSLLHRYG DQHGLRFALP 100
ARYQFGYPKL FQASRVKGYR PQGGGTQLPF HILCHHMRFN LKEVLQVMPS 150
DSFFFSIVRD PAALARSAFS YYKSTSSAFR KSPSLAAFLA NPRGFYRPGA 200
RGDHYARNLL WFDFGLPFPP EKRAKRGNIH PPRDPNPPQL QVLPSGAGPR 250
AQTLNPNALI HPVSTVTDHR SQISSPASFD LGSSSFIQWG LAWLDSVFDL 300
VMVAEYFDES LVLLADALCW GLDDVVGFMH NAQAGHKQGL STVSNSGLTA 350
EDRQLTARAR AWNNLDWALY VHFNRSLWAR IEKYGQGRLQ TAVAELRARR 400
EALAKHCLVG GEASDPKYIT DRRFRPFQFG SAKVLGYILR SGLSPQDQEE 450
CERLATPELQ YKDKLDAKQF PPTVSLPLKT SRPLSP 486
Length:486
Mass (Da):54,166
Last modified:December 1, 2001 - v1
Checksum:i2D731D16B191CC3C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti353 – 3531R → Q.
Corresponds to variant rs3800952 [ dbSNP | Ensembl ].
VAR_021989
Natural varianti467 – 4671A → V.2 Publications
Corresponds to variant rs3823646 [ dbSNP | Ensembl ].
VAR_033736

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371M → L in BAB13977. 1 Publication
Sequence conflicti201 – 2044RGDH → VGTT in AAL55759. 1 Publication
Sequence conflicti441 – 4411S → R in BAB13977. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316113 mRNA. Translation: AAK73365.1.
AF289575 mRNA. Translation: AAL55759.1.
AK022178 mRNA. Translation: BAB13977.1.
AL833824 mRNA. Translation: CAD38686.2.
CH236956 Genomic DNA. Translation: EAL23847.1.
CH471091 Genomic DNA. Translation: EAW76575.1.
CH471091 Genomic DNA. Translation: EAW76577.1.
CH471091 Genomic DNA. Translation: EAW76579.1.
BC012976 mRNA. Translation: AAH12976.1.
CCDSiCCDS5688.1.
RefSeqiNP_078913.3. NM_024637.4.
UniGeneiHs.44856.

Genome annotation databases

EnsembliENST00000360039; ENSP00000353142; ENSG00000197093.
ENST00000413800; ENSP00000400451; ENSG00000197093.
GeneIDi79690.
KEGGihsa:79690.
UCSCiuc003utt.3. human.

Polymorphism databases

DMDMi47116570.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316113 mRNA. Translation: AAK73365.1 .
AF289575 mRNA. Translation: AAL55759.1 .
AK022178 mRNA. Translation: BAB13977.1 .
AL833824 mRNA. Translation: CAD38686.2 .
CH236956 Genomic DNA. Translation: EAL23847.1 .
CH471091 Genomic DNA. Translation: EAW76575.1 .
CH471091 Genomic DNA. Translation: EAW76577.1 .
CH471091 Genomic DNA. Translation: EAW76579.1 .
BC012976 mRNA. Translation: AAH12976.1 .
CCDSi CCDS5688.1.
RefSeqi NP_078913.3. NM_024637.4.
UniGenei Hs.44856.

3D structure databases

ProteinModelPortali Q96RP7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122811. 1 interaction.

PTM databases

PhosphoSitei Q96RP7.

Polymorphism databases

DMDMi 47116570.

Proteomic databases

PaxDbi Q96RP7.
PRIDEi Q96RP7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360039 ; ENSP00000353142 ; ENSG00000197093 .
ENST00000413800 ; ENSP00000400451 ; ENSG00000197093 .
GeneIDi 79690.
KEGGi hsa:79690.
UCSCi uc003utt.3. human.

Organism-specific databases

CTDi 79690.
GeneCardsi GC07M099770.
HGNCi HGNC:24145. GAL3ST4.
HPAi HPA038137.
MIMi 608235. gene.
neXtProti NX_Q96RP7.
PharmGKBi PA134921067.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26344.
HOVERGENi HBG051681.
InParanoidi Q96RP7.
KOi K09677.
OMAi DHYARNL.
OrthoDBi EOG7K0ZF1.
PhylomeDBi Q96RP7.
TreeFami TF314802.

Enzyme and pathway databases

UniPathwayi UPA00353 .

Miscellaneous databases

GeneWikii GAL3ST4.
GenomeRNAii 79690.
NextBioi 68960.
PROi Q96RP7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96RP7.
Bgeei Q96RP7.
CleanExi HS_GAL3ST4.
Genevestigatori Q96RP7.

Family and domain databases

InterProi IPR009729. Gal-3-0_sulfotransfrase.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR14647. PTHR14647. 1 hit.
Pfami PF06990. Gal-3-0_sulfotr. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human galactose 3-O-sulfotransferase that transfers sulfate to Galbeta1->3GalNAc residue in O-glycans."
    Seko A., Hara-Kuge S., Yamashita K.
    J. Biol. Chem. 276:25697-25704(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-467.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-467.
    Tissue: Placenta.

Entry informationi

Entry nameiG3ST4_HUMAN
AccessioniPrimary (citable) accession number: Q96RP7
Secondary accession number(s): A4D2A8
, D6W5U5, Q8N3P7, Q8WZ17, Q96E33, Q9HA78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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