ID   UCN2_HUMAN              Reviewed;         112 AA.
AC   Q96RP3; Q9BUG0;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   24-JAN-2024, entry version 149.
DE   RecName: Full=Urocortin-2;
DE   AltName: Full=Stresscopin-related peptide;
DE   AltName: Full=Urocortin II;
DE            Short=Ucn II;
DE   AltName: Full=Urocortin-related peptide;
DE   Flags: Precursor;
GN   Name=UCN2; Synonyms=SRP, URP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11329063; DOI=10.1038/87936;
RA   Hsu S.Y., Hsueh A.J.W.;
RT   "Human stresscopin and stresscopin-related peptide are selective ligands
RT   for the type 2 corticotropin-releasing hormone receptor.";
RL   Nat. Med. 7:605-611(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   LACK OF AMIDATION.
RX   PubMed=23493376; DOI=10.1210/en.2012-2011;
RA   Vaughan J.M., Donaldson C.J., Fischer W.H., Perrin M.H., Rivier J.E.,
RA   Sawchenko P.E., Vale W.W.;
RT   "Posttranslational processing of human and mouse urocortin 2:
RT   characterization and bioactivity of gene products.";
RL   Endocrinology 154:1553-1564(2013).
RN   [4]
RP   STRUCTURE BY NMR OF 72-109.
RX   PubMed=18052377; DOI=10.1021/ja0760933;
RA   Grace C.R.R., Perrin M.H., Cantle J.P., Vale W.W., Rivier J.E., Riek R.;
RT   "Common and divergent structural features of a series of corticotropin
RT   releasing factor-related peptides.";
RL   J. Am. Chem. Soc. 129:16102-16114(2007).
RN   [5]
RP   X-RAY CRYSTALLOGRAPHY (2.72 ANGSTROMS) OF 94-109 IN COMPLEX WITH CRHR2.
RX   PubMed=20966082; DOI=10.1074/jbc.m110.186072;
RA   Pal K., Swaminathan K., Xu H.E., Pioszak A.A.;
RT   "Structural basis for hormone recognition by the Human CRFR2{alpha} G
RT   protein-coupled receptor.";
RL   J. Biol. Chem. 285:40351-40361(2010).
CC   -!- FUNCTION: Suppresses food intake, delays gastric emptying and decreases
CC       heat-induced edema. Might represent an endogenous ligand for
CC       maintaining homeostasis after stress.
CC   -!- SUBUNIT: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
CC       {ECO:0000269|PubMed:20966082}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   EMBL; AF320560; AAK52672.1; -; mRNA.
DR   EMBL; BC002647; AAH02647.2; -; mRNA.
DR   EMBL; BC022096; AAH22096.1; -; mRNA.
DR   CCDS; CCDS2772.1; -.
DR   RefSeq; NP_149976.1; NM_033199.3.
DR   PDB; 2RMG; NMR; -; A=72-109.
DR   PDB; 3N95; X-ray; 2.72 A; E/F=94-109.
DR   PDBsum; 2RMG; -.
DR   PDBsum; 3N95; -.
DR   AlphaFoldDB; Q96RP3; -.
DR   SMR; Q96RP3; -.
DR   BioGRID; 124679; 2.
DR   IntAct; Q96RP3; 2.
DR   STRING; 9606.ENSP00000273610; -.
DR   BioMuta; UCN2; -.
DR   DMDM; 20532289; -.
DR   MassIVE; Q96RP3; -.
DR   PaxDb; 9606-ENSP00000273610; -.
DR   Antibodypedia; 55296; 207 antibodies from 24 providers.
DR   DNASU; 90226; -.
DR   Ensembl; ENST00000273610.4; ENSP00000273610.3; ENSG00000145040.4.
DR   GeneID; 90226; -.
DR   KEGG; hsa:90226; -.
DR   MANE-Select; ENST00000273610.4; ENSP00000273610.3; NM_033199.4; NP_149976.1.
DR   UCSC; uc003cty.2; human.
DR   AGR; HGNC:18414; -.
DR   CTD; 90226; -.
DR   DisGeNET; 90226; -.
DR   GeneCards; UCN2; -.
DR   HGNC; HGNC:18414; UCN2.
DR   HPA; ENSG00000145040; Tissue enhanced (skin, vagina).
DR   MIM; 605902; gene.
DR   neXtProt; NX_Q96RP3; -.
DR   OpenTargets; ENSG00000145040; -.
DR   PharmGKB; PA133787055; -.
DR   VEuPathDB; HostDB:ENSG00000145040; -.
DR   eggNOG; ENOG502R23K; Eukaryota.
DR   GeneTree; ENSGT00940000160568; -.
DR   HOGENOM; CLU_2145078_0_0_1; -.
DR   InParanoid; Q96RP3; -.
DR   OMA; TWPWAAQ; -.
DR   PhylomeDB; Q96RP3; -.
DR   TreeFam; TF330723; -.
DR   PathwayCommons; Q96RP3; -.
DR   Reactome; R-HSA-373080; Class B/2 (Secretin family receptors).
DR   SignaLink; Q96RP3; -.
DR   BioGRID-ORCS; 90226; 11 hits in 1141 CRISPR screens.
DR   EvolutionaryTrace; Q96RP3; -.
DR   GeneWiki; UCN2; -.
DR   GenomeRNAi; 90226; -.
DR   Pharos; Q96RP3; Tbio.
DR   PRO; PR:Q96RP3; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q96RP3; Protein.
DR   Bgee; ENSG00000145040; Expressed in stromal cell of endometrium and 72 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0051431; F:corticotropin-releasing hormone receptor 2 binding; IEA:InterPro.
DR   GO; GO:0051429; F:corticotropin-releasing hormone receptor binding; IPI:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042562; F:hormone binding; IPI:UniProtKB.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR   GO; GO:0031669; P:cellular response to nutrient levels; IBA:GO_Central.
DR   GO; GO:0007586; P:digestion; NAS:UniProtKB.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IDA:UniProtKB.
DR   InterPro; IPR000187; CRF.
DR   InterPro; IPR024270; Urocortin_II/III.
DR   PANTHER; PTHR17575:SF0; UROCORTIN-2; 1.
DR   PANTHER; PTHR17575; UROCORTIN-2 AND 3; 1.
DR   Pfam; PF00473; CRF; 1.
DR   Genevisible; Q96RP3; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Glycoprotein; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   PROPEP          23..70
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000006239"
FT   CHAIN           72..112
FT                   /note="Urocortin-2"
FT                   /id="PRO_0000006240"
FT   REGION          27..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           80..88
FT                   /evidence="ECO:0007829|PDB:2RMG"
FT   HELIX           95..108
FT                   /evidence="ECO:0007829|PDB:3N95"
SQ   SEQUENCE   112 AA;  12146 MW;  0EFF29A3463723D4 CRC64;
     MTRCALLLLM VLMLGRVLVV PVTPIPTFQL RPQNSPQTTP RPAASESPSA APTWPWAAQS
     HCSPTRHPGS RIVLSLDVPI GLLQILLEQA RARAAREQAT TNARILARVG HC
//