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Q96RP3 (UCN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Urocortin-2
Alternative name(s):
Stresscopin-related peptide
Urocortin II
Short name=Ucn II
Urocortin-related peptide
Gene names
Name:UCN2
Synonyms:SRP, URP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length112 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

Subunit structure

Binds with high affinity to CRF receptors 2-alpha and 2-beta.

Subcellular location

Secreted.

Post-translational modification

Glycosylated By similarity.

Sequence similarities

Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Propeptide23 – 7048 By similarity
PRO_0000006239
Chain72 – 11241Urocortin-2
PRO_0000006240

Secondary structure

..... 112
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q96RP3 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 0EFF29A3463723D4

FASTA11212,146
        10         20         30         40         50         60 
MTRCALLLLM VLMLGRVLVV PVTPIPTFQL RPQNSPQTTP RPAASESPSA APTWPWAAQS 

        70         80         90        100        110 
HCSPTRHPGS RIVLSLDVPI GLLQILLEQA RARAAREQAT TNARILARVG HC 

« Hide

References

« Hide 'large scale' references
[1]"Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor."
Hsu S.Y., Hsueh A.J.W.
Nat. Med. 7:605-611(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin and Uterus.
[3]"Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products."
Vaughan J.M., Donaldson C.J., Fischer W.H., Perrin M.H., Rivier J.E., Sawchenko P.E., Vale W.W.
Endocrinology 154:1553-1564(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: LACK OF AMIDATION.
[4]"Common and divergent structural features of a series of corticotropin releasing factor-related peptides."
Grace C.R.R., Perrin M.H., Cantle J.P., Vale W.W., Rivier J.E., Riek R.
J. Am. Chem. Soc. 129:16102-16114(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 72-109.
[5]"Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."
Pal K., Swaminathan K., Xu H.E., Pioszak A.A.
J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.72 ANGSTROMS) OF 94-109 IN COMPLEX WITH CRHR2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF320560 mRNA. Translation: AAK52672.1.
BC002647 mRNA. Translation: AAH02647.2.
BC022096 mRNA. Translation: AAH22096.1.
RefSeqNP_149976.1. NM_033199.3.
UniGeneHs.631914.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2RMGNMR-A72-109[»]
3N95X-ray2.72E/F94-109[»]
ProteinModelPortalQ96RP3.
SMRQ96RP3. Positions 72-109.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124679. 2 interactions.
STRING9606.ENSP00000273610.

Polymorphism databases

DMDM20532289.

Proteomic databases

PaxDbQ96RP3.
PRIDEQ96RP3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000273610; ENSP00000273610; ENSG00000145040.
GeneID90226.
KEGGhsa:90226.
UCSCuc003cty.1. human.

Organism-specific databases

CTD90226.
GeneCardsGC03M048575.
HGNCHGNC:18414. UCN2.
MIM605902. gene.
neXtProtNX_Q96RP3.
PharmGKBPA133787055.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43191.
HOGENOMHOG000154768.
HOVERGENHBG036242.
InParanoidQ96RP3.
KOK05257.
OMAQNSPQTT.
OrthoDBEOG73BVGS.
PhylomeDBQ96RP3.
TreeFamTF330723.

Gene expression databases

BgeeQ96RP3.
CleanExHS_UCN2.
GenevestigatorQ96RP3.

Family and domain databases

InterProIPR000187. Corticotropin-releasing_factor.
IPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERPTHR17575. PTHR17575. 1 hit.
PfamPF11613. UCN2. 1 hit.
[Graphical view]
ProDomPD455741. PD455741. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00039. CRF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ96RP3.
GeneWikiUCN2.
GenomeRNAi90226.
NextBio76603.
PROQ96RP3.
SOURCESearch...

Entry information

Entry nameUCN2_HUMAN
AccessionPrimary (citable) accession number: Q96RP3
Secondary accession number(s): Q9BUG0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM