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Protein

Urocortin-2

Gene

UCN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • hormone binding Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin-2
Alternative name(s):
Stresscopin-related peptide
Urocortin II
Short name:
Ucn II
Urocortin-related peptide
Gene namesi
Name:UCN2
Synonyms:SRP, URP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18414. UCN2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA133787055.

Polymorphism and mutation databases

BioMutaiUCN2.
DMDMi20532289.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Propeptidei23 – 7048By similarityPRO_0000006239Add
BLAST
Chaini72 – 11241Urocortin-2PRO_0000006240Add
BLAST

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96RP3.
PRIDEiQ96RP3.

Expressioni

Gene expression databases

BgeeiQ96RP3.
CleanExiHS_UCN2.
GenevisibleiQ96RP3. HS.

Interactioni

Subunit structurei

Binds with high affinity to CRF receptors 2-alpha and 2-beta.1 Publication

Protein-protein interaction databases

BioGridi124679. 2 interactions.
STRINGi9606.ENSP00000273610.

Structurei

Secondary structure

1
112
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi80 – 889Combined sources
Helixi95 – 10814Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RMGNMR-A72-109[»]
3N95X-ray2.72E/F94-109[»]
ProteinModelPortaliQ96RP3.
SMRiQ96RP3. Positions 72-109.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96RP3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43191.
GeneTreeiENSGT00390000004650.
HOGENOMiHOG000154768.
HOVERGENiHBG036242.
InParanoidiQ96RP3.
KOiK05257.
OMAiQNSPQTT.
OrthoDBiEOG73BVGS.
PhylomeDBiQ96RP3.
TreeFamiTF330723.

Family and domain databases

InterProiIPR000187. Corticotropin-releasing_factor.
IPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERiPTHR17575. PTHR17575. 1 hit.
PTHR17575:SF0. PTHR17575:SF0. 1 hit.
PfamiPF11613. UCN2. 1 hit.
[Graphical view]
ProDomiPD455741. PD455741. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00039. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96RP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRCALLLLM VLMLGRVLVV PVTPIPTFQL RPQNSPQTTP RPAASESPSA
60 70 80 90 100
APTWPWAAQS HCSPTRHPGS RIVLSLDVPI GLLQILLEQA RARAAREQAT
110
TNARILARVG HC
Length:112
Mass (Da):12,146
Last modified:December 1, 2001 - v1
Checksum:i0EFF29A3463723D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320560 mRNA. Translation: AAK52672.1.
BC002647 mRNA. Translation: AAH02647.2.
BC022096 mRNA. Translation: AAH22096.1.
CCDSiCCDS2772.1.
RefSeqiNP_149976.1. NM_033199.3.
UniGeneiHs.631914.

Genome annotation databases

EnsembliENST00000273610; ENSP00000273610; ENSG00000145040.
GeneIDi90226.
KEGGihsa:90226.
UCSCiuc003cty.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320560 mRNA. Translation: AAK52672.1.
BC002647 mRNA. Translation: AAH02647.2.
BC022096 mRNA. Translation: AAH22096.1.
CCDSiCCDS2772.1.
RefSeqiNP_149976.1. NM_033199.3.
UniGeneiHs.631914.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RMGNMR-A72-109[»]
3N95X-ray2.72E/F94-109[»]
ProteinModelPortaliQ96RP3.
SMRiQ96RP3. Positions 72-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124679. 2 interactions.
STRINGi9606.ENSP00000273610.

Polymorphism and mutation databases

BioMutaiUCN2.
DMDMi20532289.

Proteomic databases

PaxDbiQ96RP3.
PRIDEiQ96RP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273610; ENSP00000273610; ENSG00000145040.
GeneIDi90226.
KEGGihsa:90226.
UCSCiuc003cty.1. human.

Organism-specific databases

CTDi90226.
GeneCardsiGC03M048599.
HGNCiHGNC:18414. UCN2.
MIMi605902. gene.
neXtProtiNX_Q96RP3.
PharmGKBiPA133787055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43191.
GeneTreeiENSGT00390000004650.
HOGENOMiHOG000154768.
HOVERGENiHBG036242.
InParanoidiQ96RP3.
KOiK05257.
OMAiQNSPQTT.
OrthoDBiEOG73BVGS.
PhylomeDBiQ96RP3.
TreeFamiTF330723.

Miscellaneous databases

EvolutionaryTraceiQ96RP3.
GeneWikiiUCN2.
GenomeRNAii90226.
NextBioi76603.
PROiQ96RP3.
SOURCEiSearch...

Gene expression databases

BgeeiQ96RP3.
CleanExiHS_UCN2.
GenevisibleiQ96RP3. HS.

Family and domain databases

InterProiIPR000187. Corticotropin-releasing_factor.
IPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERiPTHR17575. PTHR17575. 1 hit.
PTHR17575:SF0. PTHR17575:SF0. 1 hit.
PfamiPF11613. UCN2. 1 hit.
[Graphical view]
ProDomiPD455741. PD455741. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor."
    Hsu S.Y., Hsueh A.J.W.
    Nat. Med. 7:605-611(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin and Uterus.
  3. "Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products."
    Vaughan J.M., Donaldson C.J., Fischer W.H., Perrin M.H., Rivier J.E., Sawchenko P.E., Vale W.W.
    Endocrinology 154:1553-1564(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF AMIDATION.
  4. "Common and divergent structural features of a series of corticotropin releasing factor-related peptides."
    Grace C.R.R., Perrin M.H., Cantle J.P., Vale W.W., Rivier J.E., Riek R.
    J. Am. Chem. Soc. 129:16102-16114(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 72-109.
  5. "Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."
    Pal K., Swaminathan K., Xu H.E., Pioszak A.A.
    J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.72 ANGSTROMS) OF 94-109 IN COMPLEX WITH CRHR2.

Entry informationi

Entry nameiUCN2_HUMAN
AccessioniPrimary (citable) accession number: Q96RP3
Secondary accession number(s): Q9BUG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.