Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96RP3

- UCN2_HUMAN

UniProt

Q96RP3 - UCN2_HUMAN

Protein

Urocortin-2

Gene

UCN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

    GO - Molecular functioni

    1. hormone binding Source: UniProtKB
    2. receptor binding Source: UniProtKB

    GO - Biological processi

    1. cAMP biosynthetic process Source: UniProtKB
    2. cell proliferation Source: Ensembl
    3. cellular response to glucocorticoid stimulus Source: Ensembl
    4. cellular response to hypoxia Source: Ensembl
    5. digestion Source: UniProtKB
    6. negative regulation of follicle-stimulating hormone secretion Source: Ensembl
    7. negative regulation of gene expression Source: Ensembl
    8. negative regulation of luteinizing hormone secretion Source: Ensembl
    9. response to stress Source: UniProtKB

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urocortin-2
    Alternative name(s):
    Stresscopin-related peptide
    Urocortin II
    Short name:
    Ucn II
    Urocortin-related peptide
    Gene namesi
    Name:UCN2
    Synonyms:SRP, URP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:18414. UCN2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA133787055.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Propeptidei23 – 7048By similarityPRO_0000006239Add
    BLAST
    Chaini72 – 11241Urocortin-2PRO_0000006240Add
    BLAST

    Post-translational modificationi

    Glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ96RP3.
    PRIDEiQ96RP3.

    Expressioni

    Gene expression databases

    BgeeiQ96RP3.
    CleanExiHS_UCN2.
    GenevestigatoriQ96RP3.

    Interactioni

    Subunit structurei

    Binds with high affinity to CRF receptors 2-alpha and 2-beta.1 Publication

    Protein-protein interaction databases

    BioGridi124679. 2 interactions.
    STRINGi9606.ENSP00000273610.

    Structurei

    Secondary structure

    1
    112
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi80 – 889
    Helixi95 – 10814

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2RMGNMR-A72-109[»]
    3N95X-ray2.72E/F94-109[»]
    ProteinModelPortaliQ96RP3.
    SMRiQ96RP3. Positions 72-109.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96RP3.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43191.
    HOGENOMiHOG000154768.
    HOVERGENiHBG036242.
    InParanoidiQ96RP3.
    KOiK05257.
    OMAiQNSPQTT.
    OrthoDBiEOG73BVGS.
    PhylomeDBiQ96RP3.
    TreeFamiTF330723.

    Family and domain databases

    InterProiIPR000187. Corticotropin-releasing_factor.
    IPR024273. Urocortin_II.
    IPR024270. Urocortin_II/III.
    [Graphical view]
    PANTHERiPTHR17575. PTHR17575. 1 hit.
    PTHR17575:SF0. PTHR17575:SF0. 1 hit.
    PfamiPF11613. UCN2. 1 hit.
    [Graphical view]
    ProDomiPD455741. PD455741. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00039. CRF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96RP3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRCALLLLM VLMLGRVLVV PVTPIPTFQL RPQNSPQTTP RPAASESPSA    50
    APTWPWAAQS HCSPTRHPGS RIVLSLDVPI GLLQILLEQA RARAAREQAT 100
    TNARILARVG HC 112
    Length:112
    Mass (Da):12,146
    Last modified:December 1, 2001 - v1
    Checksum:i0EFF29A3463723D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF320560 mRNA. Translation: AAK52672.1.
    BC002647 mRNA. Translation: AAH02647.2.
    BC022096 mRNA. Translation: AAH22096.1.
    CCDSiCCDS2772.1.
    RefSeqiNP_149976.1. NM_033199.3.
    UniGeneiHs.631914.

    Genome annotation databases

    EnsembliENST00000273610; ENSP00000273610; ENSG00000145040.
    GeneIDi90226.
    KEGGihsa:90226.
    UCSCiuc003cty.1. human.

    Polymorphism databases

    DMDMi20532289.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF320560 mRNA. Translation: AAK52672.1 .
    BC002647 mRNA. Translation: AAH02647.2 .
    BC022096 mRNA. Translation: AAH22096.1 .
    CCDSi CCDS2772.1.
    RefSeqi NP_149976.1. NM_033199.3.
    UniGenei Hs.631914.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2RMG NMR - A 72-109 [» ]
    3N95 X-ray 2.72 E/F 94-109 [» ]
    ProteinModelPortali Q96RP3.
    SMRi Q96RP3. Positions 72-109.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124679. 2 interactions.
    STRINGi 9606.ENSP00000273610.

    Polymorphism databases

    DMDMi 20532289.

    Proteomic databases

    PaxDbi Q96RP3.
    PRIDEi Q96RP3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273610 ; ENSP00000273610 ; ENSG00000145040 .
    GeneIDi 90226.
    KEGGi hsa:90226.
    UCSCi uc003cty.1. human.

    Organism-specific databases

    CTDi 90226.
    GeneCardsi GC03M048575.
    HGNCi HGNC:18414. UCN2.
    MIMi 605902. gene.
    neXtProti NX_Q96RP3.
    PharmGKBi PA133787055.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43191.
    HOGENOMi HOG000154768.
    HOVERGENi HBG036242.
    InParanoidi Q96RP3.
    KOi K05257.
    OMAi QNSPQTT.
    OrthoDBi EOG73BVGS.
    PhylomeDBi Q96RP3.
    TreeFami TF330723.

    Miscellaneous databases

    EvolutionaryTracei Q96RP3.
    GeneWikii UCN2.
    GenomeRNAii 90226.
    NextBioi 76603.
    PROi Q96RP3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96RP3.
    CleanExi HS_UCN2.
    Genevestigatori Q96RP3.

    Family and domain databases

    InterProi IPR000187. Corticotropin-releasing_factor.
    IPR024273. Urocortin_II.
    IPR024270. Urocortin_II/III.
    [Graphical view ]
    PANTHERi PTHR17575. PTHR17575. 1 hit.
    PTHR17575:SF0. PTHR17575:SF0. 1 hit.
    Pfami PF11613. UCN2. 1 hit.
    [Graphical view ]
    ProDomi PD455741. PD455741. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00039. CRF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor."
      Hsu S.Y., Hsueh A.J.W.
      Nat. Med. 7:605-611(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin and Uterus.
    3. "Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products."
      Vaughan J.M., Donaldson C.J., Fischer W.H., Perrin M.H., Rivier J.E., Sawchenko P.E., Vale W.W.
      Endocrinology 154:1553-1564(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF AMIDATION.
    4. "Common and divergent structural features of a series of corticotropin releasing factor-related peptides."
      Grace C.R.R., Perrin M.H., Cantle J.P., Vale W.W., Rivier J.E., Riek R.
      J. Am. Chem. Soc. 129:16102-16114(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 72-109.
    5. "Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."
      Pal K., Swaminathan K., Xu H.E., Pioszak A.A.
      J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.72 ANGSTROMS) OF 94-109 IN COMPLEX WITH CRHR2.

    Entry informationi

    Entry nameiUCN2_HUMAN
    AccessioniPrimary (citable) accession number: Q96RP3
    Secondary accession number(s): Q9BUG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3