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Q96RP3

- UCN2_HUMAN

UniProt

Q96RP3 - UCN2_HUMAN

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Protein

Urocortin-2

Gene

UCN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

GO - Molecular functioni

  1. hormone binding Source: UniProtKB
  2. receptor binding Source: UniProtKB

GO - Biological processi

  1. cAMP biosynthetic process Source: UniProtKB
  2. cell proliferation Source: Ensembl
  3. cellular response to glucocorticoid stimulus Source: Ensembl
  4. cellular response to hypoxia Source: Ensembl
  5. digestion Source: UniProtKB
  6. negative regulation of follicle-stimulating hormone secretion Source: Ensembl
  7. negative regulation of gene expression Source: Ensembl
  8. negative regulation of luteinizing hormone secretion Source: Ensembl
  9. response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin-2
Alternative name(s):
Stresscopin-related peptide
Urocortin II
Short name:
Ucn II
Urocortin-related peptide
Gene namesi
Name:UCN2
Synonyms:SRP, URP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:18414. UCN2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA133787055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Propeptidei23 – 7048By similarityPRO_0000006239Add
BLAST
Chaini72 – 11241Urocortin-2PRO_0000006240Add
BLAST

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96RP3.
PRIDEiQ96RP3.

Expressioni

Gene expression databases

BgeeiQ96RP3.
CleanExiHS_UCN2.
GenevestigatoriQ96RP3.

Interactioni

Subunit structurei

Binds with high affinity to CRF receptors 2-alpha and 2-beta.1 Publication

Protein-protein interaction databases

BioGridi124679. 2 interactions.
STRINGi9606.ENSP00000273610.

Structurei

Secondary structure

1
112
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi80 – 889
Helixi95 – 10814

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RMGNMR-A72-109[»]
3N95X-ray2.72E/F94-109[»]
ProteinModelPortaliQ96RP3.
SMRiQ96RP3. Positions 72-109.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96RP3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43191.
GeneTreeiENSGT00390000004650.
HOGENOMiHOG000154768.
HOVERGENiHBG036242.
InParanoidiQ96RP3.
KOiK05257.
OMAiQNSPQTT.
OrthoDBiEOG73BVGS.
PhylomeDBiQ96RP3.
TreeFamiTF330723.

Family and domain databases

InterProiIPR000187. Corticotropin-releasing_factor.
IPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERiPTHR17575. PTHR17575. 1 hit.
PTHR17575:SF0. PTHR17575:SF0. 1 hit.
PfamiPF11613. UCN2. 1 hit.
[Graphical view]
ProDomiPD455741. PD455741. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00039. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96RP3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRCALLLLM VLMLGRVLVV PVTPIPTFQL RPQNSPQTTP RPAASESPSA
60 70 80 90 100
APTWPWAAQS HCSPTRHPGS RIVLSLDVPI GLLQILLEQA RARAAREQAT
110
TNARILARVG HC
Length:112
Mass (Da):12,146
Last modified:December 1, 2001 - v1
Checksum:i0EFF29A3463723D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF320560 mRNA. Translation: AAK52672.1.
BC002647 mRNA. Translation: AAH02647.2.
BC022096 mRNA. Translation: AAH22096.1.
CCDSiCCDS2772.1.
RefSeqiNP_149976.1. NM_033199.3.
UniGeneiHs.631914.

Genome annotation databases

EnsembliENST00000273610; ENSP00000273610; ENSG00000145040.
GeneIDi90226.
KEGGihsa:90226.
UCSCiuc003cty.1. human.

Polymorphism databases

DMDMi20532289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF320560 mRNA. Translation: AAK52672.1 .
BC002647 mRNA. Translation: AAH02647.2 .
BC022096 mRNA. Translation: AAH22096.1 .
CCDSi CCDS2772.1.
RefSeqi NP_149976.1. NM_033199.3.
UniGenei Hs.631914.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2RMG NMR - A 72-109 [» ]
3N95 X-ray 2.72 E/F 94-109 [» ]
ProteinModelPortali Q96RP3.
SMRi Q96RP3. Positions 72-109.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124679. 2 interactions.
STRINGi 9606.ENSP00000273610.

Polymorphism databases

DMDMi 20532289.

Proteomic databases

PaxDbi Q96RP3.
PRIDEi Q96RP3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273610 ; ENSP00000273610 ; ENSG00000145040 .
GeneIDi 90226.
KEGGi hsa:90226.
UCSCi uc003cty.1. human.

Organism-specific databases

CTDi 90226.
GeneCardsi GC03M048599.
HGNCi HGNC:18414. UCN2.
MIMi 605902. gene.
neXtProti NX_Q96RP3.
PharmGKBi PA133787055.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43191.
GeneTreei ENSGT00390000004650.
HOGENOMi HOG000154768.
HOVERGENi HBG036242.
InParanoidi Q96RP3.
KOi K05257.
OMAi QNSPQTT.
OrthoDBi EOG73BVGS.
PhylomeDBi Q96RP3.
TreeFami TF330723.

Miscellaneous databases

EvolutionaryTracei Q96RP3.
GeneWikii UCN2.
GenomeRNAii 90226.
NextBioi 76603.
PROi Q96RP3.
SOURCEi Search...

Gene expression databases

Bgeei Q96RP3.
CleanExi HS_UCN2.
Genevestigatori Q96RP3.

Family and domain databases

InterProi IPR000187. Corticotropin-releasing_factor.
IPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view ]
PANTHERi PTHR17575. PTHR17575. 1 hit.
PTHR17575:SF0. PTHR17575:SF0. 1 hit.
Pfami PF11613. UCN2. 1 hit.
[Graphical view ]
ProDomi PD455741. PD455741. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00039. CRF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor."
    Hsu S.Y., Hsueh A.J.W.
    Nat. Med. 7:605-611(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin and Uterus.
  3. "Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products."
    Vaughan J.M., Donaldson C.J., Fischer W.H., Perrin M.H., Rivier J.E., Sawchenko P.E., Vale W.W.
    Endocrinology 154:1553-1564(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF AMIDATION.
  4. "Common and divergent structural features of a series of corticotropin releasing factor-related peptides."
    Grace C.R.R., Perrin M.H., Cantle J.P., Vale W.W., Rivier J.E., Riek R.
    J. Am. Chem. Soc. 129:16102-16114(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 72-109.
  5. "Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."
    Pal K., Swaminathan K., Xu H.E., Pioszak A.A.
    J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.72 ANGSTROMS) OF 94-109 IN COMPLEX WITH CRHR2.

Entry informationi

Entry nameiUCN2_HUMAN
AccessioniPrimary (citable) accession number: Q96RP3
Secondary accession number(s): Q9BUG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3