Q96RP3 (UCN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urocortin-2

Alternative name(s):
Stresscopin-related peptide
Urocortin II
Short name=Ucn II
Urocortin-related peptide

Gene names

Name:	UCN2
Synonyms:	SRP, URP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	112 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
Subunit structure	Binds with high affinity to CRF receptors 2-alpha and 2-beta.
Subcellular location	Secreted.
Sequence similarities	Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cAMP biosynthetic process Inferred from expression pattern Ref.1. Source: UniProtKB cell proliferation Inferred from electronic annotation. Source: Compara cellular response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara cellular response to hypoxia Inferred from electronic annotation. Source: Compara digestion Non-traceable author statement Ref.1. Source: UniProtKB negative regulation of follicle-stimulating hormone secretion Inferred from electronic annotation. Source: Compara negative regulation of gene expression Inferred from electronic annotation. Source: Compara negative regulation of luteinizing hormone secretion Inferred from electronic annotation. Source: Compara response to stress Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	extracellular region Non-traceable author statement Ref.1. Source: UniProtKB extracellular space Inferred from electronic annotation. Source: Compara
Molecular_function	hormone binding Inferred from physical interaction Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

19

Potential

Propeptide

20 – 70

51

Potential

PRO_0000006239

Chain

72 – 112

41

Urocortin-2

PRO_0000006240

Secondary structure

1

.

.

.

.

.

112

Helix Strand Turn

Details...

Helix

80 – 88

9

Helix

95 – 108

14

Sequences

	Sequence		Length	Mass (Da)
	Q96RP3 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 0EFF29A3463723D4	FASTA	112	12,146
	10 20 30 40 50 60 MTRCALLLLM VLMLGRVLVV PVTPIPTFQL RPQNSPQTTP RPAASESPSA APTWPWAAQS 70 80 90 100 110 HCSPTRHPGS RIVLSLDVPI GLLQILLEQA RARAAREQAT TNARILARVG HC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor." Hsu S.Y., Hsueh A.J.W. Nat. Med. 7:605-611(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin and Uterus.
[3]	"Common and divergent structural features of a series of corticotropin releasing factor-related peptides." Grace C.R.R., Perrin M.H., Cantle J.P., Vale W.W., Rivier J.E., Riek R. J. Am. Chem. Soc. 129:16102-16114(2007) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 72-109.
[4]	"Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor." Pal K., Swaminathan K., Xu H.E., Pioszak A.A. J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.72 ANGSTROMS) OF 94-109 IN COMPLEX WITH CRHR2.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF320560 mRNA. Translation: AAK52672.1.
BC002647 mRNA. Translation: AAH02647.2.
BC022096 mRNA. Translation: AAH22096.1.

IPI

IPI00030945.

RefSeq

NP_149976.1. NM_033199.3.

UniGene

Hs.631914.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2RMG	NMR	-	A	72-109	[»]
3N95	X-ray	2.72	E/F	94-109	[»]

ProteinModelPortal

Q96RP3.

SMR

Q96RP3. Positions 72-109.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000273610.

Polymorphism databases

DMDM

20532289.

Proteomic databases

PaxDb

Q96RP3.

PRIDE

Q96RP3.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000273610; ENSP00000273610; ENSG00000145040.

GeneID

90226.

KEGG

hsa:90226.

UCSC

uc003cty.1. human.

Organism-specific databases

CTD

90226.

GeneCards

GC03M048575.

HGNC

HGNC:18414. UCN2.

MIM

605902. gene.

neXtProt

NX_Q96RP3.

PharmGKB

PA133787055.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG43191.

HOGENOM

HOG000154768.

HOVERGEN

HBG036242.

InParanoid

Q96RP3.

KO

K05257.

OMA

PGPRITL.

OrthoDB

EOG4QFWG1.

PhylomeDB

Q96RP3.

Gene expression databases

Bgee

Q96RP3.

CleanEx

HS_UCN2.

Genevestigator

Q96RP3.

GermOnline

ENSG00000145040. Homo sapiens.

Family and domain databases

InterPro

IPR000187. Corticotropin-releasing_factor.
IPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view]

PANTHER

PTHR17575. PTHR17575. 1 hit.

Pfam

PF11613. UCN2. 1 hit.
[Graphical view]

ProDom

PD455741. PD455741. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00039. CRF. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q96RP3.

GenomeRNAi

90226.

NextBio

76603.

SOURCE

Search...

Entry information

Entry name

UCN2_HUMAN

Accession

Primary (citable) accession number: Q96RP3
Secondary accession number(s): Q9BUG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.