Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Urocortin-2

Gene

UCN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • hormone binding Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • cAMP biosynthetic process Source: UniProtKB
  • cellular response to nutrient levels Source: GO_Central
  • digestion Source: UniProtKB
  • response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145040-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin-2
Alternative name(s):
Stresscopin-related peptide
Urocortin II
Short name:
Ucn II
Urocortin-related peptide
Gene namesi
Name:UCN2
Synonyms:SRP, URP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18414. UCN2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi90226.
OpenTargetsiENSG00000145040.
PharmGKBiPA133787055.

Polymorphism and mutation databases

BioMutaiUCN2.
DMDMi20532289.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
PropeptideiPRO_000000623923 – 70By similarityAdd BLAST48
ChainiPRO_000000624072 – 112Urocortin-2Add BLAST41

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96RP3.
PRIDEiQ96RP3.

Expressioni

Gene expression databases

BgeeiENSG00000145040.
CleanExiHS_UCN2.
GenevisibleiQ96RP3. HS.

Organism-specific databases

HPAiHPA066841.

Interactioni

Subunit structurei

Binds with high affinity to CRF receptors 2-alpha and 2-beta.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124679. 2 interactors.
STRINGi9606.ENSP00000273610.

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi80 – 88Combined sources9
Helixi95 – 108Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RMGNMR-A72-109[»]
3N95X-ray2.72E/F94-109[»]
ProteinModelPortaliQ96RP3.
SMRiQ96RP3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96RP3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5CP. Eukaryota.
ENOG4111C21. LUCA.
GeneTreeiENSGT00390000004650.
HOGENOMiHOG000154768.
HOVERGENiHBG036242.
InParanoidiQ96RP3.
KOiK05257.
OMAiQNSPQTT.
PhylomeDBiQ96RP3.
TreeFamiTF330723.

Family and domain databases

InterProiIPR000187. CRF.
IPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERiPTHR17575. PTHR17575. 1 hit.
PTHR17575:SF0. PTHR17575:SF0. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
ProDomiPD455741. PD455741. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96RP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRCALLLLM VLMLGRVLVV PVTPIPTFQL RPQNSPQTTP RPAASESPSA
60 70 80 90 100
APTWPWAAQS HCSPTRHPGS RIVLSLDVPI GLLQILLEQA RARAAREQAT
110
TNARILARVG HC
Length:112
Mass (Da):12,146
Last modified:December 1, 2001 - v1
Checksum:i0EFF29A3463723D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320560 mRNA. Translation: AAK52672.1.
BC002647 mRNA. Translation: AAH02647.2.
BC022096 mRNA. Translation: AAH22096.1.
CCDSiCCDS2772.1.
RefSeqiNP_149976.1. NM_033199.3.
UniGeneiHs.631914.

Genome annotation databases

EnsembliENST00000273610; ENSP00000273610; ENSG00000145040.
GeneIDi90226.
KEGGihsa:90226.
UCSCiuc003cty.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320560 mRNA. Translation: AAK52672.1.
BC002647 mRNA. Translation: AAH02647.2.
BC022096 mRNA. Translation: AAH22096.1.
CCDSiCCDS2772.1.
RefSeqiNP_149976.1. NM_033199.3.
UniGeneiHs.631914.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RMGNMR-A72-109[»]
3N95X-ray2.72E/F94-109[»]
ProteinModelPortaliQ96RP3.
SMRiQ96RP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124679. 2 interactors.
STRINGi9606.ENSP00000273610.

Polymorphism and mutation databases

BioMutaiUCN2.
DMDMi20532289.

Proteomic databases

PaxDbiQ96RP3.
PRIDEiQ96RP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273610; ENSP00000273610; ENSG00000145040.
GeneIDi90226.
KEGGihsa:90226.
UCSCiuc003cty.2. human.

Organism-specific databases

CTDi90226.
DisGeNETi90226.
GeneCardsiUCN2.
HGNCiHGNC:18414. UCN2.
HPAiHPA066841.
MIMi605902. gene.
neXtProtiNX_Q96RP3.
OpenTargetsiENSG00000145040.
PharmGKBiPA133787055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J5CP. Eukaryota.
ENOG4111C21. LUCA.
GeneTreeiENSGT00390000004650.
HOGENOMiHOG000154768.
HOVERGENiHBG036242.
InParanoidiQ96RP3.
KOiK05257.
OMAiQNSPQTT.
PhylomeDBiQ96RP3.
TreeFamiTF330723.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145040-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ96RP3.
GeneWikiiUCN2.
GenomeRNAii90226.
PROiQ96RP3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145040.
CleanExiHS_UCN2.
GenevisibleiQ96RP3. HS.

Family and domain databases

InterProiIPR000187. CRF.
IPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERiPTHR17575. PTHR17575. 1 hit.
PTHR17575:SF0. PTHR17575:SF0. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
ProDomiPD455741. PD455741. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiUCN2_HUMAN
AccessioniPrimary (citable) accession number: Q96RP3
Secondary accession number(s): Q9BUG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.