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Q96RN1

- S26A8_HUMAN

UniProt

Q96RN1 - S26A8_HUMAN

Protein

Testis anion transporter 1

Gene

SLC26A8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.3 Publications

    Enzyme regulationi

    Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters), gluconate, and by thiosulfate.

    GO - Molecular functioni

    1. anion:anion antiporter activity Source: UniProtKB-KW
    2. chloride channel activity Source: UniProtKB
    3. oxalate transmembrane transporter activity Source: UniProtKB
    4. protein binding Source: IntAct
    5. sulfate transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. anion transport Source: UniProtKB
    2. cell differentiation Source: UniProtKB-KW
    3. chloride transmembrane transport Source: GOC
    4. chloride transport Source: UniProtKB
    5. meiotic nuclear division Source: UniProtKB-KW
    6. multicellular organismal development Source: UniProtKB-KW
    7. oxalate transport Source: UniProtKB
    8. spermatogenesis Source: UniProtKB-KW
    9. sulfate transmembrane transport Source: GOC
    10. sulfate transport Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Anion exchange, Differentiation, Ion transport, Meiosis, Spermatogenesis, Transport

    Protein family/group databases

    TCDBi2.A.53.2.14. the sulfate permease (sulp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testis anion transporter 1
    Alternative name(s):
    Anion exchange transporter
    Solute carrier family 26 member 8
    Gene namesi
    Name:SLC26A8Imported
    Synonyms:TAT11 Publication
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:14468. SLC26A8.

    Subcellular locationi

    Membrane 2 Publications; Multi-pass membrane protein 2 Publications
    Note: Located at the annulus ring structure within the sperm cell.2 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Spermatogenic failure 3 (SPGF3) [MIM:606766]: A disorder characterized by primary infertility, sperm morphologic abnormalities, and moderate to severe asthenozoospermia, condition in which the percentage of progressively motile sperm is abnormally low.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti87 – 871R → Q in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
    VAR_070058
    Natural varianti812 – 8121E → K in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
    VAR_070059
    Natural varianti954 – 9541R → C in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
    VAR_070060

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi914 – 9141P → S: Not a cause of male infertility. 1 Publication

    Organism-specific databases

    MIMi606766. phenotype.
    PharmGKBiPA37885.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 970970Testis anion transporter 1PRO_0000322586Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ96RN1.
    PRIDEiQ96RN1.

    PTM databases

    PhosphoSiteiQ96RN1.

    Expressioni

    Tissue specificityi

    Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa.2 Publications

    Inductioni

    Repressed by tunicamycin, an inhibitor of N-glycosylation.1 Publication

    Gene expression databases

    ArrayExpressiQ96RN1.
    BgeeiQ96RN1.
    CleanExiHS_SLC26A8.
    GenevestigatoriQ96RN1.

    Organism-specific databases

    HPAiHPA038080.
    HPA038081.

    Interactioni

    Subunit structurei

    Interacts with RACGAP1. Interacts with CFTR.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CFTRP135692EBI-1792052,EBI-349854
    RACGAP1Q9H0H52EBI-1792052,EBI-717233

    Protein-protein interaction databases

    BioGridi125501. 2 interactions.
    IntActiQ96RN1. 2 interactions.
    STRINGi9606.ENSP00000347778.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96RN1.
    SMRiQ96RN1. Positions 710-799.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9595CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini117 – 1193ExtracellularSequence Analysis
    Topological domaini141 – 1466CytoplasmicSequence Analysis
    Topological domaini168 – 20235ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 2329CytoplasmicSequence Analysis
    Topological domaini254 – 27017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 30716CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini329 – 35527ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini377 – 39216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini414 – 42916ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini451 – 4522CytoplasmicSequence Analysis
    Topological domaini474 – 49724ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini519 – 970452CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 32821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei356 – 37621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei393 – 41321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei430 – 45021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei453 – 47321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei498 – 51821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini543 – 795253STASPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni664 – 970307Interaction with RACGAP11 PublicationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 STAS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0659.
    HOGENOMiHOG000154234.
    HOVERGENiHBG108443.
    InParanoidiQ96RN1.
    KOiK14705.
    OMAiIFGSCHQ.
    OrthoDBiEOG73BVBX.
    PhylomeDBiQ96RN1.
    TreeFamiTF313784.

    Family and domain databases

    Gene3Di3.30.750.24. 2 hits.
    InterProiIPR002645. STAS_dom.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PfamiPF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 2 hits.
    PROSITEiPS50801. STAS. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 13 Publications (identifier: Q96RN1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQLERSAIS GFSSKSRRNS FAYDVKREVY NEETFQQEHK RKASSSGNMN    50
    INITTFRHHV QCRCSWHRFL RCVLTIFPFL EWMCMYRLKD WLLGDLLAGI 100
    SVGLVQVPQG LTLSLLARQL IPPLNIAYAA FCSSVIYVIF GSCHQMSIGS 150
    FFLVSALLIN VLKVSPFNNG QLVMGSFVKN EFSAPSYLMG YNKSLSVVAT 200
    TTFLTGIIQL IMGVLGLGFI ATYLPESAMS AYLAAVALHI MLSQLTFIFG 250
    IMISFHAGPI SFFYDIINYC VALPKANSTS ILVFLTVVVA LRINKCIRIS 300
    FNQYPIEFPM ELFLIIGFTV IANKISMATE TSQTLIDMIP YSFLLPVTPD 350
    FSLLPKIILQ AFSLSLVSSF LLIFLGKKIA SLHNYSVNSN QDLIAIGLCN 400
    VVSSFFRSCV FTGAIARTII QDKSGGRQQF ASLVGAGVML LLMVKMGHFF 450
    YTLPNAVLAG IILSNVIPYL ETISNLPSLW RQDQYDCALW MMTFSSSIFL 500
    GLDIGLIISV VSAFFITTVR SHRAKILLLG QIPNTNIYRS INDYREIITI 550
    PGVKIFQCCS SITFVNVYYL KHKLLKEVDM VKVPLKEEEI FSLFNSSDTN 600
    LQGGKICRCF CNCDDLEPLP RILYTERFEN KLDPEASSIN LIHCSHFESM 650
    NTSQTASEDQ VPYTVSSVSQ KNQGQQYEEV EEVWLPNNSS RNSSPGLPDV 700
    AESQGRRSLI PYSDASLLPS VHTIILDFSM VHYVDSRGLV VLRQICNAFQ 750
    NANILILIAG CHSSIVRAFE RNDFFDAGIT KTQLFLSVHD AVLFALSRKV 800
    IGSSELSIDE SETVIRETYS ETDKNDNSRY KMSSSFLGSQ KNVSPGFIKI 850
    QQPVEEESEL DLELESEQEA GLGLDLDLDR ELEPEMEPKA ETETKTQTEM 900
    EPQPETEPEM EPNPKSRPRA HTFPQQRYWP MYHPSMASTQ SQTQTRTWSV 950
    ERRRHPMDSY SPEGNSNEDV 970
    Length:970
    Mass (Da):109,006
    Last modified:December 1, 2001 - v1
    Checksum:i7F932A9CFE3A9EC4
    GO
    Isoform 21 Publication (identifier: Q96RN1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         210-314: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:865
    Mass (Da):97,353
    Checksum:i95925D014048905D
    GO
    Isoform 31 Publication (identifier: Q96RN1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-419: Missing.
         420-428: IQDKSGGRQ → VSLQLALSP

    Note: No experimental confirmation available.Curated

    Show »
    Length:552
    Mass (Da):62,455
    Checksum:iFBB6C75D929BB281
    GO
    Isoform 41 Publication (identifier: Q96RN1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         745-768: ICNAFQNANILILIAGCHSSIVRA → VSTEEALAGALIPLLPSQPHPDPD
         769-970: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:768
    Mass (Da):85,680
    Checksum:i2A3BD6BC6188401F
    GO

    Sequence cautioni

    The sequence AAO26699.1 differs from that shown. Reason: Incorrectly indicated as originating from mouse.
    The sequence BAB71408.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti168 – 1681N → D in AAL26868. 1 PublicationCurated
    Sequence conflicti168 – 1681N → D in AAO26699. 1 PublicationCurated
    Sequence conflicti560 – 5601S → C in AAL26868. 1 PublicationCurated
    Sequence conflicti560 – 5601S → C in AAO26699. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti73 – 731V → M Not a cause of male infertility. 4 Publications
    Corresponds to variant rs743923 [ dbSNP | Ensembl ].
    VAR_039464
    Natural varianti87 – 871R → Q in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
    VAR_070058
    Natural varianti148 – 1481I → V Not a cause of male infertility. 2 Publications
    Corresponds to variant rs17713154 [ dbSNP | Ensembl ].
    VAR_039465
    Natural varianti230 – 2301S → N Not a cause of male infertility. 2 Publications
    Corresponds to variant rs17707331 [ dbSNP | Ensembl ].
    VAR_039466
    Natural varianti639 – 6391I → V Not a cause of male infertility. 4 Publications
    Corresponds to variant rs2295852 [ dbSNP | Ensembl ].
    VAR_039467
    Natural varianti812 – 8121E → K in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
    VAR_070059
    Natural varianti954 – 9541R → C in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
    VAR_070060

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 419418Missing in isoform 3. 1 PublicationVSP_052704Add
    BLAST
    Alternative sequencei210 – 314105Missing in isoform 2. 1 PublicationVSP_052705Add
    BLAST
    Alternative sequencei420 – 4289IQDKSGGRQ → VSLQLALSP in isoform 3. 1 PublicationVSP_052706
    Alternative sequencei745 – 76824ICNAF…SIVRA → VSTEEALAGALIPLLPSQPH PDPD in isoform 4. 1 PublicationVSP_052707Add
    BLAST
    Alternative sequencei769 – 970202Missing in isoform 4. 1 PublicationVSP_052708Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF331522 mRNA. Translation: AAK95666.1.
    AF314959 mRNA. Translation: AAL26868.1.
    AF403499 mRNA. Translation: AAO26699.1.
    AL133507, Z95152 Genomic DNA. Translation: CAI40884.1.
    Z95152, AL133507 Genomic DNA. Translation: CAI19692.1.
    AL133507 Genomic DNA. Translation: CAI40882.1.
    CH471081 Genomic DNA. Translation: EAX03862.1.
    BC025408 mRNA. Translation: AAH25408.1.
    AK057276 mRNA. Translation: BAB71408.1. Different initiation.
    CCDSiCCDS4813.1. [Q96RN1-1]
    CCDS4814.1. [Q96RN1-2]
    RefSeqiNP_001180405.1. NM_001193476.1. [Q96RN1-1]
    NP_443193.1. NM_052961.3. [Q96RN1-1]
    NP_619732.2. NM_138718.2. [Q96RN1-2]
    UniGeneiHs.435836.

    Genome annotation databases

    EnsembliENST00000355574; ENSP00000347778; ENSG00000112053. [Q96RN1-1]
    ENST00000394602; ENSP00000378100; ENSG00000112053. [Q96RN1-2]
    ENST00000490799; ENSP00000417638; ENSG00000112053. [Q96RN1-1]
    GeneIDi116369.
    KEGGihsa:116369.
    UCSCiuc003olk.3. human. [Q96RN1-3]
    uc003oll.3. human. [Q96RN1-2]
    uc003olm.3. human. [Q96RN1-1]

    Polymorphism databases

    DMDMi74761075.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF331522 mRNA. Translation: AAK95666.1 .
    AF314959 mRNA. Translation: AAL26868.1 .
    AF403499 mRNA. Translation: AAO26699.1 .
    AL133507 , Z95152 Genomic DNA. Translation: CAI40884.1 .
    Z95152 , AL133507 Genomic DNA. Translation: CAI19692.1 .
    AL133507 Genomic DNA. Translation: CAI40882.1 .
    CH471081 Genomic DNA. Translation: EAX03862.1 .
    BC025408 mRNA. Translation: AAH25408.1 .
    AK057276 mRNA. Translation: BAB71408.1 . Different initiation.
    CCDSi CCDS4813.1. [Q96RN1-1 ]
    CCDS4814.1. [Q96RN1-2 ]
    RefSeqi NP_001180405.1. NM_001193476.1. [Q96RN1-1 ]
    NP_443193.1. NM_052961.3. [Q96RN1-1 ]
    NP_619732.2. NM_138718.2. [Q96RN1-2 ]
    UniGenei Hs.435836.

    3D structure databases

    ProteinModelPortali Q96RN1.
    SMRi Q96RN1. Positions 710-799.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125501. 2 interactions.
    IntActi Q96RN1. 2 interactions.
    STRINGi 9606.ENSP00000347778.

    Protein family/group databases

    TCDBi 2.A.53.2.14. the sulfate permease (sulp) family.

    PTM databases

    PhosphoSitei Q96RN1.

    Polymorphism databases

    DMDMi 74761075.

    Proteomic databases

    PaxDbi Q96RN1.
    PRIDEi Q96RN1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355574 ; ENSP00000347778 ; ENSG00000112053 . [Q96RN1-1 ]
    ENST00000394602 ; ENSP00000378100 ; ENSG00000112053 . [Q96RN1-2 ]
    ENST00000490799 ; ENSP00000417638 ; ENSG00000112053 . [Q96RN1-1 ]
    GeneIDi 116369.
    KEGGi hsa:116369.
    UCSCi uc003olk.3. human. [Q96RN1-3 ]
    uc003oll.3. human. [Q96RN1-2 ]
    uc003olm.3. human. [Q96RN1-1 ]

    Organism-specific databases

    CTDi 116369.
    GeneCardsi GC06M035911.
    HGNCi HGNC:14468. SLC26A8.
    HPAi HPA038080.
    HPA038081.
    MIMi 606766. phenotype.
    608480. gene.
    neXtProti NX_Q96RN1.
    PharmGKBi PA37885.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0659.
    HOGENOMi HOG000154234.
    HOVERGENi HBG108443.
    InParanoidi Q96RN1.
    KOi K14705.
    OMAi IFGSCHQ.
    OrthoDBi EOG73BVBX.
    PhylomeDBi Q96RN1.
    TreeFami TF313784.

    Miscellaneous databases

    GeneWikii SLC26A8.
    GenomeRNAii 116369.
    NextBioi 79881.
    PROi Q96RN1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96RN1.
    Bgeei Q96RN1.
    CleanExi HS_SLC26A8.
    Genevestigatori Q96RN1.

    Family and domain databases

    Gene3Di 3.30.750.24. 2 hits.
    InterProi IPR002645. STAS_dom.
    IPR011547. Sulph_transpt.
    [Graphical view ]
    Pfami PF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 2 hits.
    PROSITEi PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling."
      Toure A., Morin L., Pineau C., Becq F., Dorseuil O., Gacon G.
      J. Biol. Chem. 276:20309-20315(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH RACGAP1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, GLYCOSYLATION, VARIANT MET-73.
      Tissue: Testis1 Publication.
    2. "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9."
      Lohi H., Kujala M., Maekelae S., Lehtonen E., Kestilae M., Saarialho-Kere U., Markovich D., Kere J.
      J. Biol. Chem. 277:14246-14254(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INHIBITION.
    3. "Cloning of human SLC26A8, a new member of the sulphate transporter gene family of anion transporter/exchangers."
      Mount D.B.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-73; VAL-148; ASN-230 AND VAL-639.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS MET-73 AND VAL-639.
      Tissue: TestisImported.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 450-768 (ISOFORM 4).
      Tissue: TestisImported.
    8. "The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation."
      Rode B., Dirami T., Bakouh N., Rizk-Rabin M., Norez C., Lhuillier P., Lores P., Jollivet M., Melin P., Zvetkova I., Bienvenu T., Becq F., Planelles G., Edelman A., Gacon G., Toure A.
      Hum. Mol. Genet. 21:1287-1298(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SPERM CAPACITATION, INTERACTION WITH CFTR.
    9. "Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure."
      Makela S., Eklund R., Lahdetie J., Mikkola M., Hovatta O., Kere J.
      Mol. Hum. Reprod. 11:129-132(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS MET-73; VAL-148; ASN-230 AND VAL-639, MUTAGENESIS OF PRO-914.
    10. "The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse."
      Toure A., Lhuillier P., Gossen J.A., Kuil C.W., Lhote D., Jegou B., Escalier D., Gacon G.
      Hum. Mol. Genet. 16:1783-1793(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    11. "Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia."
      Dirami T., Rode B., Jollivet M., Da Silva N., Escalier D., Gaitch N., Norez C., Tuffery P., Wolf J.P., Becq F., Ray P.F., Dulioust E., Gacon G., Bienvenu T., Toure A.
      Am. J. Hum. Genet. 92:760-766(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SPGF3 GLN-87; LYS-812 AND CYS-954, CHARACTERIZATION OF VARIANTS SPGF3 GLN-87; LYS-812 AND CYS-954.

    Entry informationi

    Entry nameiS26A8_HUMAN
    AccessioniPrimary (citable) accession number: Q96RN1
    Secondary accession number(s): Q5JVR5
    , Q812C7, Q8TC65, Q96MA0, Q96PK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3