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Q96RN1 (S26A8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Testis anion transporter 1
Alternative name(s):
Anion exchange transporter
Solute carrier family 26 member 8
Gene names
Name:SLC26A8
Synonyms:TAT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length970 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation. Ref.1 Ref.2 Ref.8 UniProtKB Q8R0C3

Enzyme regulation

Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters), gluconate, and by thiosulfate.

Subunit structure

Interacts with RACGAP1. Interacts with CFTR. Ref.1 Ref.8

Subcellular location

Membrane; Multi-pass membrane protein. Note: Located at the annulus ring structure within the sperm cell. Ref.1 Ref.10

Tissue specificity

Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa. Ref.1 Ref.2

Induction

Repressed by tunicamycin, an inhibitor of N-glycosylation. Ref.1

Post-translational modification

N-glycosylated. Ref.1

Involvement in disease

Spermatogenic failure 3 (SPGF3) [MIM:606766]: A disorder characterized by primary infertility, sperm morphologic abnormalities, and moderate to severe asthenozoospermia, condition in which the percentage of progressively motile sperm is abnormally low.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.11

Sequence similarities

Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification]

Contains 1 STAS domain.

Sequence caution

The sequence AAO26699.1 differs from that shown. Reason: Incorrectly indicated as originating from mouse.

The sequence BAB71408.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processAnion exchange
Differentiation
Ion transport
Meiosis
Spermatogenesis
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionDevelopmental protein
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanion transport

Inferred from direct assay Ref.2. Source: UniProtKB

cell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

chloride transmembrane transport

Inferred from direct assay PubMed 1183472. Source: GOC

chloride transport

Inferred from direct assay PubMed 1183472. Source: UniProtKB

meiotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

oxalate transport

Inferred from direct assay PubMed 1183472. Source: UniProtKB

spermatogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

sulfate transmembrane transport

Inferred from direct assay PubMed 1183472. Source: GOC

sulfate transport

Inferred from direct assay PubMed 1183472. Source: UniProtKB

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from direct assay Ref.1. Source: UniProtKB

   Molecular_functionanion:anion antiporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

chloride channel activity

Inferred from direct assay PubMed 1183472. Source: UniProtKB

oxalate transmembrane transporter activity

Inferred from direct assay PubMed 1183472. Source: UniProtKB

sulfate transmembrane transporter activity

Inferred from direct assay PubMed 1183472. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CFTRP135692EBI-1792052,EBI-349854
RACGAP1Q9H0H52EBI-1792052,EBI-717233

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 Ref.2 Ref.6 (identifier: Q96RN1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.6 (identifier: Q96RN1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     210-314: Missing.
Note: No experimental confirmation available.
Isoform 3 Ref.4 (identifier: Q96RN1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2-419: Missing.
     420-428: IQDKSGGRQ → VSLQLALSP
Note: No experimental confirmation available.
Isoform 4 Ref.7 (identifier: Q96RN1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     745-768: ICNAFQNANILILIAGCHSSIVRA → VSTEEALAGALIPLLPSQPHPDPD
     769-970: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 970970Testis anion transporter 1
PRO_0000322586

Regions

Topological domain1 – 9595Cytoplasmic Potential
Transmembrane96 – 11621Helical; Potential
Topological domain117 – 1193Extracellular Potential
Transmembrane120 – 14021Helical; Potential
Topological domain141 – 1466Cytoplasmic Potential
Transmembrane147 – 16721Helical; Potential
Topological domain168 – 20235Extracellular Potential
Transmembrane203 – 22321Helical; Potential
Topological domain224 – 2329Cytoplasmic Potential
Transmembrane233 – 25321Helical; Potential
Topological domain254 – 27017Extracellular Potential
Transmembrane271 – 29121Helical; Potential
Topological domain292 – 30716Cytoplasmic Potential
Transmembrane308 – 32821Helical; Potential
Topological domain329 – 35527Extracellular Potential
Transmembrane356 – 37621Helical; Potential
Topological domain377 – 39216Cytoplasmic Potential
Transmembrane393 – 41321Helical; Potential
Topological domain414 – 42916Extracellular Potential
Transmembrane430 – 45021Helical; Potential
Topological domain451 – 4522Cytoplasmic Potential
Transmembrane453 – 47321Helical; Potential
Topological domain474 – 49724Extracellular Potential
Transmembrane498 – 51821Helical; Potential
Topological domain519 – 970452Cytoplasmic Potential
Domain543 – 795253STAS
Region664 – 970307Interaction with RACGAP1 Ref.1

Amino acid modifications

Glycosylation1921N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence2 – 419418Missing in isoform 3. Ref.4
VSP_052704
Alternative sequence210 – 314105Missing in isoform 2. Ref.6
VSP_052705
Alternative sequence420 – 4289IQDKSGGRQ → VSLQLALSP in isoform 3. Ref.4
VSP_052706
Alternative sequence745 – 76824ICNAF…SIVRA → VSTEEALAGALIPLLPSQPH PDPD in isoform 4. Ref.7
VSP_052707
Alternative sequence769 – 970202Missing in isoform 4. Ref.7
VSP_052708
Natural variant731V → M Not a cause of male infertility. Ref.1 Ref.3 Ref.6 Ref.9
Corresponds to variant rs743923 [ dbSNP | Ensembl ].
VAR_039464
Natural variant871R → Q in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. Ref.11
VAR_070058
Natural variant1481I → V Not a cause of male infertility. Ref.3 Ref.6 Ref.9
Corresponds to variant rs17713154 [ dbSNP | Ensembl ].
VAR_039465
Natural variant2301S → N Not a cause of male infertility. Ref.3 Ref.6 Ref.9
Corresponds to variant rs17707331 [ dbSNP | Ensembl ].
VAR_039466
Natural variant6391I → V Not a cause of male infertility. Ref.1 Ref.3 Ref.6 Ref.9
Corresponds to variant rs2295852 [ dbSNP | Ensembl ].
VAR_039467
Natural variant8121E → K in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. Ref.11
VAR_070059
Natural variant9541R → C in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. Ref.11
VAR_070060

Experimental info

Mutagenesis9141P → S: Not a cause of male infertility. Ref.9
Sequence conflict1681N → D in AAL26868. Ref.3
Sequence conflict1681N → D in AAO26699. Ref.3
Sequence conflict5601S → C in AAL26868. Ref.3
Sequence conflict5601S → C in AAO26699. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 7F932A9CFE3A9EC4

FASTA970109,006
        10         20         30         40         50         60 
MAQLERSAIS GFSSKSRRNS FAYDVKREVY NEETFQQEHK RKASSSGNMN INITTFRHHV 

        70         80         90        100        110        120 
QCRCSWHRFL RCVLTIFPFL EWMCMYRLKD WLLGDLLAGI SVGLVQVPQG LTLSLLARQL 

       130        140        150        160        170        180 
IPPLNIAYAA FCSSVIYVIF GSCHQMSIGS FFLVSALLIN VLKVSPFNNG QLVMGSFVKN 

       190        200        210        220        230        240 
EFSAPSYLMG YNKSLSVVAT TTFLTGIIQL IMGVLGLGFI ATYLPESAMS AYLAAVALHI 

       250        260        270        280        290        300 
MLSQLTFIFG IMISFHAGPI SFFYDIINYC VALPKANSTS ILVFLTVVVA LRINKCIRIS 

       310        320        330        340        350        360 
FNQYPIEFPM ELFLIIGFTV IANKISMATE TSQTLIDMIP YSFLLPVTPD FSLLPKIILQ 

       370        380        390        400        410        420 
AFSLSLVSSF LLIFLGKKIA SLHNYSVNSN QDLIAIGLCN VVSSFFRSCV FTGAIARTII 

       430        440        450        460        470        480 
QDKSGGRQQF ASLVGAGVML LLMVKMGHFF YTLPNAVLAG IILSNVIPYL ETISNLPSLW 

       490        500        510        520        530        540 
RQDQYDCALW MMTFSSSIFL GLDIGLIISV VSAFFITTVR SHRAKILLLG QIPNTNIYRS 

       550        560        570        580        590        600 
INDYREIITI PGVKIFQCCS SITFVNVYYL KHKLLKEVDM VKVPLKEEEI FSLFNSSDTN 

       610        620        630        640        650        660 
LQGGKICRCF CNCDDLEPLP RILYTERFEN KLDPEASSIN LIHCSHFESM NTSQTASEDQ 

       670        680        690        700        710        720 
VPYTVSSVSQ KNQGQQYEEV EEVWLPNNSS RNSSPGLPDV AESQGRRSLI PYSDASLLPS 

       730        740        750        760        770        780 
VHTIILDFSM VHYVDSRGLV VLRQICNAFQ NANILILIAG CHSSIVRAFE RNDFFDAGIT 

       790        800        810        820        830        840 
KTQLFLSVHD AVLFALSRKV IGSSELSIDE SETVIRETYS ETDKNDNSRY KMSSSFLGSQ 

       850        860        870        880        890        900 
KNVSPGFIKI QQPVEEESEL DLELESEQEA GLGLDLDLDR ELEPEMEPKA ETETKTQTEM 

       910        920        930        940        950        960 
EPQPETEPEM EPNPKSRPRA HTFPQQRYWP MYHPSMASTQ SQTQTRTWSV ERRRHPMDSY 

       970 
SPEGNSNEDV 

« Hide

Isoform 2 [UniParc].

Checksum: 95925D014048905D
Show »

FASTA86597,353
Isoform 3 [UniParc].

Checksum: FBB6C75D929BB281
Show »

FASTA55262,455
Isoform 4 [UniParc].

Checksum: 2A3BD6BC6188401F
Show »

FASTA76885,680

References

« Hide 'large scale' references
[1]"Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling."
Toure A., Morin L., Pineau C., Becq F., Dorseuil O., Gacon G.
J. Biol. Chem. 276:20309-20315(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH RACGAP1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, GLYCOSYLATION, VARIANT MET-73.
Tissue: Testis.
[2]"Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9."
Lohi H., Kujala M., Maekelae S., Lehtonen E., Kestilae M., Saarialho-Kere U., Markovich D., Kere J.
J. Biol. Chem. 277:14246-14254(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INHIBITION.
[3]"Cloning of human SLC26A8, a new member of the sulphate transporter gene family of anion transporter/exchangers."
Mount D.B.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-73; VAL-148; ASN-230 AND VAL-639.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS MET-73 AND VAL-639.
Tissue: Testis.
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 450-768 (ISOFORM 4).
Tissue: Testis.
[8]"The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation."
Rode B., Dirami T., Bakouh N., Rizk-Rabin M., Norez C., Lhuillier P., Lores P., Jollivet M., Melin P., Zvetkova I., Bienvenu T., Becq F., Planelles G., Edelman A., Gacon G., Toure A.
Hum. Mol. Genet. 21:1287-1298(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN SPERM CAPACITATION, INTERACTION WITH CFTR.
[9]"Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure."
Makela S., Eklund R., Lahdetie J., Mikkola M., Hovatta O., Kere J.
Mol. Hum. Reprod. 11:129-132(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS MET-73; VAL-148; ASN-230 AND VAL-639, MUTAGENESIS OF PRO-914.
[10]"The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse."
Toure A., Lhuillier P., Gossen J.A., Kuil C.W., Lhote D., Jegou B., Escalier D., Gacon G.
Hum. Mol. Genet. 16:1783-1793(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[11]"Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia."
Dirami T., Rode B., Jollivet M., Da Silva N., Escalier D., Gaitch N., Norez C., Tuffery P., Wolf J.P., Becq F., Ray P.F., Dulioust E., Gacon G., Bienvenu T., Toure A.
Am. J. Hum. Genet. 92:760-766(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS SPGF3 GLN-87; LYS-812 AND CYS-954, CHARACTERIZATION OF VARIANTS SPGF3 GLN-87; LYS-812 AND CYS-954.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF331522 mRNA. Translation: AAK95666.1.
AF314959 mRNA. Translation: AAL26868.1.
AF403499 mRNA. Translation: AAO26699.1.
AL133507, Z95152 Genomic DNA. Translation: CAI40884.1.
Z95152, AL133507 Genomic DNA. Translation: CAI19692.1.
AL133507 Genomic DNA. Translation: CAI40882.1.
CH471081 Genomic DNA. Translation: EAX03862.1.
BC025408 mRNA. Translation: AAH25408.1.
AK057276 mRNA. Translation: BAB71408.1. Different initiation.
RefSeqNP_001180405.1. NM_001193476.1.
NP_443193.1. NM_052961.3.
NP_619732.2. NM_138718.2.
UniGeneHs.435836.

3D structure databases

ProteinModelPortalQ96RN1.
SMRQ96RN1. Positions 710-799.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125501. 2 interactions.
IntActQ96RN1. 2 interactions.
STRING9606.ENSP00000347778.

Protein family/group databases

TCDB2.A.53.2.14. the sulfate permease (sulp) family.

PTM databases

PhosphoSiteQ96RN1.

Polymorphism databases

DMDM74761075.

Proteomic databases

PaxDbQ96RN1.
PRIDEQ96RN1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000355574; ENSP00000347778; ENSG00000112053. [Q96RN1-1]
ENST00000394602; ENSP00000378100; ENSG00000112053. [Q96RN1-2]
ENST00000490799; ENSP00000417638; ENSG00000112053. [Q96RN1-1]
GeneID116369.
KEGGhsa:116369.
UCSCuc003olk.3. human. [Q96RN1-3]
uc003oll.3. human. [Q96RN1-2]
uc003olm.3. human. [Q96RN1-1]

Organism-specific databases

CTD116369.
GeneCardsGC06M035911.
HGNCHGNC:14468. SLC26A8.
HPAHPA038080.
HPA038081.
MIM606766. phenotype.
608480. gene.
neXtProtNX_Q96RN1.
PharmGKBPA37885.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0659.
HOGENOMHOG000154234.
HOVERGENHBG108443.
InParanoidQ96RN1.
KOK14705.
OMAIFGSCHQ.
OrthoDBEOG73BVBX.
PhylomeDBQ96RN1.
TreeFamTF313784.

Gene expression databases

ArrayExpressQ96RN1.
BgeeQ96RN1.
CleanExHS_SLC26A8.
GenevestigatorQ96RN1.

Family and domain databases

Gene3D3.30.750.24. 2 hits.
InterProIPR002645. STAS_dom.
IPR011547. Sulph_transpt.
[Graphical view]
PfamPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMSSF52091. SSF52091. 2 hits.
PROSITEPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC26A8.
GenomeRNAi116369.
NextBio79881.
PROQ96RN1.
SOURCESearch...

Entry information

Entry nameS26A8_HUMAN
AccessionPrimary (citable) accession number: Q96RN1
Secondary accession number(s): Q5JVR5 expand/collapse secondary AC list , Q812C7, Q8TC65, Q96MA0, Q96PK8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

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Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Human chromosome 6

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