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Q96RN1

- S26A8_HUMAN

UniProt

Q96RN1 - S26A8_HUMAN

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Protein

Testis anion transporter 1

Gene
SLC26A8, TAT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.By similarity3 Publications

Enzyme regulationi

Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters), gluconate, and by thiosulfate.

GO - Molecular functioni

  1. anion:anion antiporter activity Source: UniProtKB-KW
  2. chloride channel activity Source: UniProtKB
  3. oxalate transmembrane transporter activity Source: UniProtKB
  4. protein binding Source: IntAct
  5. sulfate transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. anion transport Source: UniProtKB
  2. cell differentiation Source: UniProtKB-KW
  3. chloride transmembrane transport Source: GOC
  4. chloride transport Source: UniProtKB
  5. meiotic nuclear division Source: UniProtKB-KW
  6. multicellular organismal development Source: UniProtKB-KW
  7. oxalate transport Source: UniProtKB
  8. spermatogenesis Source: UniProtKB-KW
  9. sulfate transmembrane transport Source: GOC
  10. sulfate transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Anion exchange, Differentiation, Ion transport, Meiosis, Spermatogenesis, Transport

Protein family/group databases

TCDBi2.A.53.2.14. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis anion transporter 1
Alternative name(s):
Anion exchange transporter
Solute carrier family 26 member 8
Gene namesi
Name:SLC26A8
Synonyms:TAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:14468. SLC26A8.

Subcellular locationi

Membrane; Multi-pass membrane protein
Note: Located at the annulus ring structure within the sperm cell.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9595Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei96 – 11621Helical; Reviewed predictionAdd
BLAST
Topological domaini117 – 1193Extracellular Reviewed prediction
Transmembranei120 – 14021Helical; Reviewed predictionAdd
BLAST
Topological domaini141 – 1466Cytoplasmic Reviewed prediction
Transmembranei147 – 16721Helical; Reviewed predictionAdd
BLAST
Topological domaini168 – 20235Extracellular Reviewed predictionAdd
BLAST
Transmembranei203 – 22321Helical; Reviewed predictionAdd
BLAST
Topological domaini224 – 2329Cytoplasmic Reviewed prediction
Transmembranei233 – 25321Helical; Reviewed predictionAdd
BLAST
Topological domaini254 – 27017Extracellular Reviewed predictionAdd
BLAST
Transmembranei271 – 29121Helical; Reviewed predictionAdd
BLAST
Topological domaini292 – 30716Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei308 – 32821Helical; Reviewed predictionAdd
BLAST
Topological domaini329 – 35527Extracellular Reviewed predictionAdd
BLAST
Transmembranei356 – 37621Helical; Reviewed predictionAdd
BLAST
Topological domaini377 – 39216Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei393 – 41321Helical; Reviewed predictionAdd
BLAST
Topological domaini414 – 42916Extracellular Reviewed predictionAdd
BLAST
Transmembranei430 – 45021Helical; Reviewed predictionAdd
BLAST
Topological domaini451 – 4522Cytoplasmic Reviewed prediction
Transmembranei453 – 47321Helical; Reviewed predictionAdd
BLAST
Topological domaini474 – 49724Extracellular Reviewed predictionAdd
BLAST
Transmembranei498 – 51821Helical; Reviewed predictionAdd
BLAST
Topological domaini519 – 970452Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Spermatogenic failure 3 (SPGF3) [MIM:606766]: A disorder characterized by primary infertility, sperm morphologic abnormalities, and moderate to severe asthenozoospermia, condition in which the percentage of progressively motile sperm is abnormally low.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871R → Q in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
VAR_070058
Natural varianti812 – 8121E → K in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
VAR_070059
Natural varianti954 – 9541R → C in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
VAR_070060

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi914 – 9141P → S: Not a cause of male infertility. 1 Publication

Organism-specific databases

MIMi606766. phenotype.
PharmGKBiPA37885.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 970970Testis anion transporter 1PRO_0000322586Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96RN1.
PRIDEiQ96RN1.

PTM databases

PhosphoSiteiQ96RN1.

Expressioni

Tissue specificityi

Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa.2 Publications

Inductioni

Repressed by tunicamycin, an inhibitor of N-glycosylation.1 Publication

Gene expression databases

ArrayExpressiQ96RN1.
BgeeiQ96RN1.
CleanExiHS_SLC26A8.
GenevestigatoriQ96RN1.

Organism-specific databases

HPAiHPA038080.
HPA038081.

Interactioni

Subunit structurei

Interacts with RACGAP1. Interacts with CFTR.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CFTRP135692EBI-1792052,EBI-349854
RACGAP1Q9H0H52EBI-1792052,EBI-717233

Protein-protein interaction databases

BioGridi125501. 2 interactions.
IntActiQ96RN1. 2 interactions.
STRINGi9606.ENSP00000347778.

Structurei

3D structure databases

ProteinModelPortaliQ96RN1.
SMRiQ96RN1. Positions 710-799.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini543 – 795253STASAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni664 – 970307Interaction with RACGAP11 PublicationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
HOGENOMiHOG000154234.
HOVERGENiHBG108443.
InParanoidiQ96RN1.
KOiK14705.
OMAiIFGSCHQ.
OrthoDBiEOG73BVBX.
PhylomeDBiQ96RN1.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR002645. STAS_dom.
IPR011547. Sulph_transpt.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 13 Publications (identifier: Q96RN1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAQLERSAIS GFSSKSRRNS FAYDVKREVY NEETFQQEHK RKASSSGNMN    50
INITTFRHHV QCRCSWHRFL RCVLTIFPFL EWMCMYRLKD WLLGDLLAGI 100
SVGLVQVPQG LTLSLLARQL IPPLNIAYAA FCSSVIYVIF GSCHQMSIGS 150
FFLVSALLIN VLKVSPFNNG QLVMGSFVKN EFSAPSYLMG YNKSLSVVAT 200
TTFLTGIIQL IMGVLGLGFI ATYLPESAMS AYLAAVALHI MLSQLTFIFG 250
IMISFHAGPI SFFYDIINYC VALPKANSTS ILVFLTVVVA LRINKCIRIS 300
FNQYPIEFPM ELFLIIGFTV IANKISMATE TSQTLIDMIP YSFLLPVTPD 350
FSLLPKIILQ AFSLSLVSSF LLIFLGKKIA SLHNYSVNSN QDLIAIGLCN 400
VVSSFFRSCV FTGAIARTII QDKSGGRQQF ASLVGAGVML LLMVKMGHFF 450
YTLPNAVLAG IILSNVIPYL ETISNLPSLW RQDQYDCALW MMTFSSSIFL 500
GLDIGLIISV VSAFFITTVR SHRAKILLLG QIPNTNIYRS INDYREIITI 550
PGVKIFQCCS SITFVNVYYL KHKLLKEVDM VKVPLKEEEI FSLFNSSDTN 600
LQGGKICRCF CNCDDLEPLP RILYTERFEN KLDPEASSIN LIHCSHFESM 650
NTSQTASEDQ VPYTVSSVSQ KNQGQQYEEV EEVWLPNNSS RNSSPGLPDV 700
AESQGRRSLI PYSDASLLPS VHTIILDFSM VHYVDSRGLV VLRQICNAFQ 750
NANILILIAG CHSSIVRAFE RNDFFDAGIT KTQLFLSVHD AVLFALSRKV 800
IGSSELSIDE SETVIRETYS ETDKNDNSRY KMSSSFLGSQ KNVSPGFIKI 850
QQPVEEESEL DLELESEQEA GLGLDLDLDR ELEPEMEPKA ETETKTQTEM 900
EPQPETEPEM EPNPKSRPRA HTFPQQRYWP MYHPSMASTQ SQTQTRTWSV 950
ERRRHPMDSY SPEGNSNEDV 970
Length:970
Mass (Da):109,006
Last modified:December 1, 2001 - v1
Checksum:i7F932A9CFE3A9EC4
GO
Isoform 21 Publication (identifier: Q96RN1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-314: Missing.

Note: No experimental confirmation available.

Show »
Length:865
Mass (Da):97,353
Checksum:i95925D014048905D
GO
Isoform 31 Publication (identifier: Q96RN1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-419: Missing.
     420-428: IQDKSGGRQ → VSLQLALSP

Note: No experimental confirmation available.

Show »
Length:552
Mass (Da):62,455
Checksum:iFBB6C75D929BB281
GO
Isoform 41 Publication (identifier: Q96RN1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     745-768: ICNAFQNANILILIAGCHSSIVRA → VSTEEALAGALIPLLPSQPHPDPD
     769-970: Missing.

Note: No experimental confirmation available.

Show »
Length:768
Mass (Da):85,680
Checksum:i2A3BD6BC6188401F
GO

Sequence cautioni

The sequence AAO26699.1 differs from that shown. Reason: Incorrectly indicated as originating from mouse.
The sequence BAB71408.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731V → M Not a cause of male infertility. 4 Publications
Corresponds to variant rs743923 [ dbSNP | Ensembl ].
VAR_039464
Natural varianti87 – 871R → Q in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
VAR_070058
Natural varianti148 – 1481I → V Not a cause of male infertility. 3 Publications
Corresponds to variant rs17713154 [ dbSNP | Ensembl ].
VAR_039465
Natural varianti230 – 2301S → N Not a cause of male infertility. 3 Publications
Corresponds to variant rs17707331 [ dbSNP | Ensembl ].
VAR_039466
Natural varianti639 – 6391I → V Not a cause of male infertility. 4 Publications
Corresponds to variant rs2295852 [ dbSNP | Ensembl ].
VAR_039467
Natural varianti812 – 8121E → K in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
VAR_070059
Natural varianti954 – 9541R → C in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
VAR_070060

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 419418Missing in isoform 3. 1 PublicationVSP_052704Add
BLAST
Alternative sequencei210 – 314105Missing in isoform 2. 1 PublicationVSP_052705Add
BLAST
Alternative sequencei420 – 4289IQDKSGGRQ → VSLQLALSP in isoform 3. 1 PublicationVSP_052706
Alternative sequencei745 – 76824ICNAF…SIVRA → VSTEEALAGALIPLLPSQPH PDPD in isoform 4. 1 PublicationVSP_052707Add
BLAST
Alternative sequencei769 – 970202Missing in isoform 4. 1 PublicationVSP_052708Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1681N → D in AAL26868. 1 Publication
Sequence conflicti168 – 1681N → D in AAO26699. 1 Publication
Sequence conflicti560 – 5601S → C in AAL26868. 1 Publication
Sequence conflicti560 – 5601S → C in AAO26699. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF331522 mRNA. Translation: AAK95666.1.
AF314959 mRNA. Translation: AAL26868.1.
AF403499 mRNA. Translation: AAO26699.1.
AL133507, Z95152 Genomic DNA. Translation: CAI40884.1.
Z95152, AL133507 Genomic DNA. Translation: CAI19692.1.
AL133507 Genomic DNA. Translation: CAI40882.1.
CH471081 Genomic DNA. Translation: EAX03862.1.
BC025408 mRNA. Translation: AAH25408.1.
AK057276 mRNA. Translation: BAB71408.1. Different initiation.
CCDSiCCDS4813.1. [Q96RN1-1]
CCDS4814.1. [Q96RN1-2]
RefSeqiNP_001180405.1. NM_001193476.1. [Q96RN1-1]
NP_443193.1. NM_052961.3. [Q96RN1-1]
NP_619732.2. NM_138718.2. [Q96RN1-2]
UniGeneiHs.435836.

Genome annotation databases

EnsembliENST00000355574; ENSP00000347778; ENSG00000112053. [Q96RN1-1]
ENST00000394602; ENSP00000378100; ENSG00000112053. [Q96RN1-2]
ENST00000490799; ENSP00000417638; ENSG00000112053. [Q96RN1-1]
GeneIDi116369.
KEGGihsa:116369.
UCSCiuc003olk.3. human. [Q96RN1-3]
uc003oll.3. human. [Q96RN1-2]
uc003olm.3. human. [Q96RN1-1]

Polymorphism databases

DMDMi74761075.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF331522 mRNA. Translation: AAK95666.1 .
AF314959 mRNA. Translation: AAL26868.1 .
AF403499 mRNA. Translation: AAO26699.1 .
AL133507 , Z95152 Genomic DNA. Translation: CAI40884.1 .
Z95152 , AL133507 Genomic DNA. Translation: CAI19692.1 .
AL133507 Genomic DNA. Translation: CAI40882.1 .
CH471081 Genomic DNA. Translation: EAX03862.1 .
BC025408 mRNA. Translation: AAH25408.1 .
AK057276 mRNA. Translation: BAB71408.1 . Different initiation.
CCDSi CCDS4813.1. [Q96RN1-1 ]
CCDS4814.1. [Q96RN1-2 ]
RefSeqi NP_001180405.1. NM_001193476.1. [Q96RN1-1 ]
NP_443193.1. NM_052961.3. [Q96RN1-1 ]
NP_619732.2. NM_138718.2. [Q96RN1-2 ]
UniGenei Hs.435836.

3D structure databases

ProteinModelPortali Q96RN1.
SMRi Q96RN1. Positions 710-799.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125501. 2 interactions.
IntActi Q96RN1. 2 interactions.
STRINGi 9606.ENSP00000347778.

Protein family/group databases

TCDBi 2.A.53.2.14. the sulfate permease (sulp) family.

PTM databases

PhosphoSitei Q96RN1.

Polymorphism databases

DMDMi 74761075.

Proteomic databases

PaxDbi Q96RN1.
PRIDEi Q96RN1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355574 ; ENSP00000347778 ; ENSG00000112053 . [Q96RN1-1 ]
ENST00000394602 ; ENSP00000378100 ; ENSG00000112053 . [Q96RN1-2 ]
ENST00000490799 ; ENSP00000417638 ; ENSG00000112053 . [Q96RN1-1 ]
GeneIDi 116369.
KEGGi hsa:116369.
UCSCi uc003olk.3. human. [Q96RN1-3 ]
uc003oll.3. human. [Q96RN1-2 ]
uc003olm.3. human. [Q96RN1-1 ]

Organism-specific databases

CTDi 116369.
GeneCardsi GC06M035911.
HGNCi HGNC:14468. SLC26A8.
HPAi HPA038080.
HPA038081.
MIMi 606766. phenotype.
608480. gene.
neXtProti NX_Q96RN1.
PharmGKBi PA37885.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0659.
HOGENOMi HOG000154234.
HOVERGENi HBG108443.
InParanoidi Q96RN1.
KOi K14705.
OMAi IFGSCHQ.
OrthoDBi EOG73BVBX.
PhylomeDBi Q96RN1.
TreeFami TF313784.

Miscellaneous databases

GeneWikii SLC26A8.
GenomeRNAii 116369.
NextBioi 79881.
PROi Q96RN1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96RN1.
Bgeei Q96RN1.
CleanExi HS_SLC26A8.
Genevestigatori Q96RN1.

Family and domain databases

Gene3Di 3.30.750.24. 2 hits.
InterProi IPR002645. STAS_dom.
IPR011547. Sulph_transpt.
[Graphical view ]
Pfami PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 2 hits.
PROSITEi PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling."
    Toure A., Morin L., Pineau C., Becq F., Dorseuil O., Gacon G.
    J. Biol. Chem. 276:20309-20315(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH RACGAP1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, GLYCOSYLATION, VARIANT MET-73.
    Tissue: Testis.
  2. "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9."
    Lohi H., Kujala M., Maekelae S., Lehtonen E., Kestilae M., Saarialho-Kere U., Markovich D., Kere J.
    J. Biol. Chem. 277:14246-14254(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INHIBITION.
  3. "Cloning of human SLC26A8, a new member of the sulphate transporter gene family of anion transporter/exchangers."
    Mount D.B.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-73; VAL-148; ASN-230 AND VAL-639.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS MET-73 AND VAL-639.
    Tissue: Testis.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 450-768 (ISOFORM 4).
    Tissue: Testis.
  8. "The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation."
    Rode B., Dirami T., Bakouh N., Rizk-Rabin M., Norez C., Lhuillier P., Lores P., Jollivet M., Melin P., Zvetkova I., Bienvenu T., Becq F., Planelles G., Edelman A., Gacon G., Toure A.
    Hum. Mol. Genet. 21:1287-1298(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SPERM CAPACITATION, INTERACTION WITH CFTR.
  9. "Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure."
    Makela S., Eklund R., Lahdetie J., Mikkola M., Hovatta O., Kere J.
    Mol. Hum. Reprod. 11:129-132(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS MET-73; VAL-148; ASN-230 AND VAL-639, MUTAGENESIS OF PRO-914.
  10. "The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse."
    Toure A., Lhuillier P., Gossen J.A., Kuil C.W., Lhote D., Jegou B., Escalier D., Gacon G.
    Hum. Mol. Genet. 16:1783-1793(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  11. "Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia."
    Dirami T., Rode B., Jollivet M., Da Silva N., Escalier D., Gaitch N., Norez C., Tuffery P., Wolf J.P., Becq F., Ray P.F., Dulioust E., Gacon G., Bienvenu T., Toure A.
    Am. J. Hum. Genet. 92:760-766(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS SPGF3 GLN-87; LYS-812 AND CYS-954, CHARACTERIZATION OF VARIANTS SPGF3 GLN-87; LYS-812 AND CYS-954.

Entry informationi

Entry nameiS26A8_HUMAN
AccessioniPrimary (citable) accession number: Q96RN1
Secondary accession number(s): Q5JVR5
, Q812C7, Q8TC65, Q96MA0, Q96PK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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