Q96RN1 (S26A8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Testis anion transporter 1

Alternative name(s):
Anion exchange transporter
Solute carrier family 26 member 8

Gene names

Name:	SLC26A8
Synonyms:	TAT1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	970 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. Ref.1 Ref.2 Ref.8 UniProtKB Q8R0C3
Enzyme regulation	Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters), gluconate, and by thiosulfate.
Subunit structure	Interacts with RACGAP1. Ref.1
Subcellular location	Membrane; Multi-pass membrane protein. Note: Located at the annulus ring structure within the sperm cell. Ref.1 Ref.9
Tissue specificity	Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa. Ref.1 Ref.2 Ref.8
Induction	Repressed by tunicamycin, an inhibitor of N-glycosylation. Ref.1
Post-translational modification	N-glycosylated. Ref.1
Sequence similarities	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification] Contains 1 STAS domain.
Sequence caution	The sequence AAO26699.1 differs from that shown. Reason: Incorrectly indicated as originating from mouse. The sequence BAB71408.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Anion exchange Differentiation Ion transport Meiosis Spermatogenesis Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW meiosis Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Inferred from electronic annotation. Source: UniProtKB-KW sulfate transport Inferred from direct assay PubMed 1183472. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	anion:anion antiporter activity Inferred from electronic annotation. Source: UniProtKB-KW chloride channel activity Inferred from direct assay PubMed 1183472. Source: UniProtKB oxalate transmembrane transporter activity Inferred from direct assay PubMed 1183472. Source: UniProtKB sulfate transmembrane transporter activity Inferred from direct assay PubMed 1183472. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CFTR	P13569	2	EBI-1792052,EBI-349854
RACGAP1	Q9H0H5	2	EBI-1792052,EBI-717233

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 Ref.3 Ref.8 (identifier: Q96RN1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.6 (identifier: Q96RN1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     210-314: Missing.

Note: No experimental confirmation available.

Isoform 3 Ref.6 (identifier: Q96RN1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2-419: Missing.
     420-428: IQDKSGGRQ → VSLQLALSP

Note: No experimental confirmation available.

Isoform 4 Ref.9 (identifier: Q96RN1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     745-768: ICNAFQNANILILIAGCHSSIVRA → VSTEEALAGALIPLLPSQPHPDPD
     769-970: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 970	970	Testis anion transporter 1		PRO_0000322586
Regions
	Topological domain	1 – 95	95	Cytoplasmic Potential
	Transmembrane	96 – 116	21	Helical; Potential
	Topological domain	117 – 119	3	Extracellular Potential
	Transmembrane	120 – 140	21	Helical; Potential
	Topological domain	141 – 146	6	Cytoplasmic Potential
	Transmembrane	147 – 167	21	Helical; Potential
	Topological domain	168 – 202	35	Extracellular Potential
	Transmembrane	203 – 223	21	Helical; Potential
	Topological domain	224 – 232	9	Cytoplasmic Potential
	Transmembrane	233 – 253	21	Helical; Potential
	Topological domain	254 – 270	17	Extracellular Potential
	Transmembrane	271 – 291	21	Helical; Potential
	Topological domain	292 – 307	16	Cytoplasmic Potential
	Transmembrane	308 – 328	21	Helical; Potential
	Topological domain	329 – 355	27	Extracellular Potential
	Transmembrane	356 – 376	21	Helical; Potential
	Topological domain	377 – 392	16	Cytoplasmic Potential
	Transmembrane	393 – 413	21	Helical; Potential
	Topological domain	414 – 429	16	Extracellular Potential
	Transmembrane	430 – 450	21	Helical; Potential
	Topological domain	451 – 452	2	Cytoplasmic Potential
	Transmembrane	453 – 473	21	Helical; Potential
	Topological domain	474 – 497	24	Extracellular Potential
	Transmembrane	498 – 518	21	Helical; Potential
	Topological domain	519 – 970	452	Cytoplasmic Potential
	Domain	543 – 795	253	STAS
	Region	664 – 970	307	Interaction with RACGAP1 Ref.1
Amino acid modifications
	Glycosylation	192	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	2 – 419	418	Missing in isoform 3. Ref.6		VSP_052704
	Alternative sequence	210 – 314	105	Missing in isoform 2. Ref.6		VSP_052705
	Alternative sequence	420 – 428	9	IQDKSGGRQ → VSLQLALSP in isoform 3. Ref.6		VSP_052706
	Alternative sequence	745 – 768	24	ICNAF…SIVRA → VSTEEALAGALIPLLPSQPH PDPD in isoform 4. Ref.9		VSP_052707
	Alternative sequence	769 – 970	202	Missing in isoform 4. Ref.9		VSP_052708
	Natural variant	73	1	V → M Not a cause of male infertility. Ref.1 Ref.3 Ref.6 Ref.8 Corresponds to variant rs743923 [ dbSNP | Ensembl ].		VAR_039464
	Natural variant	148	1	I → V Not a cause of male infertility. Ref.3 Ref.8 Corresponds to variant rs17713154 [ dbSNP | Ensembl ].		VAR_039465
	Natural variant	230	1	S → N Not a cause of male infertility. Ref.3 Ref.8 Corresponds to variant rs17707331 [ dbSNP | Ensembl ].		VAR_039466
	Natural variant	639	1	I → V Not a cause of male infertility. Ref.1 Ref.3 Ref.6 Ref.8 Corresponds to variant rs2295852 [ dbSNP | Ensembl ].		VAR_039467
Experimental info
	Mutagenesis	914	1	P → S: Not a cause of male infertility. Ref.8
	Sequence conflict	168	1	N → D in AAL26868. Ref.3
	Sequence conflict	168	1	N → D in AAO26699. Ref.3
	Sequence conflict	560	1	S → C in AAL26868. Ref.3
	Sequence conflict	560	1	S → C in AAO26699. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 7F932A9CFE3A9EC4	FASTA	970	109,006
	10 20 30 40 50 60 MAQLERSAIS GFSSKSRRNS FAYDVKREVY NEETFQQEHK RKASSSGNMN INITTFRHHV 70 80 90 100 110 120 QCRCSWHRFL RCVLTIFPFL EWMCMYRLKD WLLGDLLAGI SVGLVQVPQG LTLSLLARQL 130 140 150 160 170 180 IPPLNIAYAA FCSSVIYVIF GSCHQMSIGS FFLVSALLIN VLKVSPFNNG QLVMGSFVKN 190 200 210 220 230 240 EFSAPSYLMG YNKSLSVVAT TTFLTGIIQL IMGVLGLGFI ATYLPESAMS AYLAAVALHI 250 260 270 280 290 300 MLSQLTFIFG IMISFHAGPI SFFYDIINYC VALPKANSTS ILVFLTVVVA LRINKCIRIS 310 320 330 340 350 360 FNQYPIEFPM ELFLIIGFTV IANKISMATE TSQTLIDMIP YSFLLPVTPD FSLLPKIILQ 370 380 390 400 410 420 AFSLSLVSSF LLIFLGKKIA SLHNYSVNSN QDLIAIGLCN VVSSFFRSCV FTGAIARTII 430 440 450 460 470 480 QDKSGGRQQF ASLVGAGVML LLMVKMGHFF YTLPNAVLAG IILSNVIPYL ETISNLPSLW 490 500 510 520 530 540 RQDQYDCALW MMTFSSSIFL GLDIGLIISV VSAFFITTVR SHRAKILLLG QIPNTNIYRS 550 560 570 580 590 600 INDYREIITI PGVKIFQCCS SITFVNVYYL KHKLLKEVDM VKVPLKEEEI FSLFNSSDTN 610 620 630 640 650 660 LQGGKICRCF CNCDDLEPLP RILYTERFEN KLDPEASSIN LIHCSHFESM NTSQTASEDQ 670 680 690 700 710 720 VPYTVSSVSQ KNQGQQYEEV EEVWLPNNSS RNSSPGLPDV AESQGRRSLI PYSDASLLPS 730 740 750 760 770 780 VHTIILDFSM VHYVDSRGLV VLRQICNAFQ NANILILIAG CHSSIVRAFE RNDFFDAGIT 790 800 810 820 830 840 KTQLFLSVHD AVLFALSRKV IGSSELSIDE SETVIRETYS ETDKNDNSRY KMSSSFLGSQ 850 860 870 880 890 900 KNVSPGFIKI QQPVEEESEL DLELESEQEA GLGLDLDLDR ELEPEMEPKA ETETKTQTEM 910 920 930 940 950 960 EPQPETEPEM EPNPKSRPRA HTFPQQRYWP MYHPSMASTQ SQTQTRTWSV ERRRHPMDSY 970 SPEGNSNEDV
	Isoform 2 [UniParc]. Checksum: 95925D014048905D	FASTA	865	97,353
	10 20 30 40 50 60 MAQLERSAIS GFSSKSRRNS FAYDVKREVY NEETFQQEHK RKASSSGNMN INITTFRHHV 70 80 90 100 110 120 QCRCSWHRFL RCVLTIFPFL EWMCMYRLKD WLLGDLLAGI SVGLVQVPQG LTLSLLARQL 130 140 150 160 170 180 IPPLNIAYAA FCSSVIYVIF GSCHQMSIGS FFLVSALLIN VLKVSPFNNG QLVMGSFVKN 190 200 210 220 230 240 EFSAPSYLMG YNKSLSVVAT TTFLTGIIQI IGFTVIANKI SMATETSQTL IDMIPYSFLL 250 260 270 280 290 300 PVTPDFSLLP KIILQAFSLS LVSSFLLIFL GKKIASLHNY SVNSNQDLIA IGLCNVVSSF 310 320 330 340 350 360 FRSCVFTGAI ARTIIQDKSG GRQQFASLVG AGVMLLLMVK MGHFFYTLPN AVLAGIILSN 370 380 390 400 410 420 VIPYLETISN LPSLWRQDQY DCALWMMTFS SSIFLGLDIG LIISVVSAFF ITTVRSHRAK 430 440 450 460 470 480 ILLLGQIPNT NIYRSINDYR EIITIPGVKI FQCCSSITFV NVYYLKHKLL KEVDMVKVPL 490 500 510 520 530 540 KEEEIFSLFN SSDTNLQGGK ICRCFCNCDD LEPLPRILYT ERFENKLDPE ASSINLIHCS 550 560 570 580 590 600 HFESMNTSQT ASEDQVPYTV SSVSQKNQGQ QYEEVEEVWL PNNSSRNSSP GLPDVAESQG 610 620 630 640 650 660 RRSLIPYSDA SLLPSVHTII LDFSMVHYVD SRGLVVLRQI CNAFQNANIL ILIAGCHSSI 670 680 690 700 710 720 VRAFERNDFF DAGITKTQLF LSVHDAVLFA LSRKVIGSSE LSIDESETVI RETYSETDKN 730 740 750 760 770 780 DNSRYKMSSS FLGSQKNVSP GFIKIQQPVE EESELDLELE SEQEAGLGLD LDLDRELEPE 790 800 810 820 830 840 MEPKAETETK TQTEMEPQPE TEPEMEPNPK SRPRAHTFPQ QRYWPMYHPS MASTQSQTQT 850 860 RTWSVERRRH PMDSYSPEGN SNEDV
	Isoform 3 [UniParc]. Checksum: FBB6C75D929BB281	FASTA	552	62,455
	10 20 30 40 50 60 MVSLQLALSP QFASLVGAGV MLLLMVKMGH FFYTLPNAVL AGIILSNVIP YLETISNLPS 70 80 90 100 110 120 LWRQDQYDCA LWMMTFSSSI FLGLDIGLII SVVSAFFITT VRSHRAKILL LGQIPNTNIY 130 140 150 160 170 180 RSINDYREII TIPGVKIFQC CSSITFVNVY YLKHKLLKEV DMVKVPLKEE EIFSLFNSSD 190 200 210 220 230 240 TNLQGGKICR CFCNCDDLEP LPRILYTERF ENKLDPEASS INLIHCSHFE SMNTSQTASE 250 260 270 280 290 300 DQVPYTVSSV SQKNQGQQYE EVEEVWLPNN SSRNSSPGLP DVAESQGRRS LIPYSDASLL 310 320 330 340 350 360 PSVHTIILDF SMVHYVDSRG LVVLRQICNA FQNANILILI AGCHSSIVRA FERNDFFDAG 370 380 390 400 410 420 ITKTQLFLSV HDAVLFALSR KVIGSSELSI DESETVIRET YSETDKNDNS RYKMSSSFLG 430 440 450 460 470 480 SQKNVSPGFI KIQQPVEEES ELDLELESEQ EAGLGLDLDL DRELEPEMEP KAETETKTQT 490 500 510 520 530 540 EMEPQPETEP EMEPNPKSRP RAHTFPQQRY WPMYHPSMAS TQSQTQTRTW SVERRRHPMD 550 SYSPEGNSNE DV
	Isoform 4 [UniParc]. Checksum: 2A3BD6BC6188401F	FASTA	768	85,680
	10 20 30 40 50 60 MAQLERSAIS GFSSKSRRNS FAYDVKREVY NEETFQQEHK RKASSSGNMN INITTFRHHV 70 80 90 100 110 120 QCRCSWHRFL RCVLTIFPFL EWMCMYRLKD WLLGDLLAGI SVGLVQVPQG LTLSLLARQL 130 140 150 160 170 180 IPPLNIAYAA FCSSVIYVIF GSCHQMSIGS FFLVSALLIN VLKVSPFNNG QLVMGSFVKN 190 200 210 220 230 240 EFSAPSYLMG YNKSLSVVAT TTFLTGIIQL IMGVLGLGFI ATYLPESAMS AYLAAVALHI 250 260 270 280 290 300 MLSQLTFIFG IMISFHAGPI SFFYDIINYC VALPKANSTS ILVFLTVVVA LRINKCIRIS 310 320 330 340 350 360 FNQYPIEFPM ELFLIIGFTV IANKISMATE TSQTLIDMIP YSFLLPVTPD FSLLPKIILQ 370 380 390 400 410 420 AFSLSLVSSF LLIFLGKKIA SLHNYSVNSN QDLIAIGLCN VVSSFFRSCV FTGAIARTII 430 440 450 460 470 480 QDKSGGRQQF ASLVGAGVML LLMVKMGHFF YTLPNAVLAG IILSNVIPYL ETISNLPSLW 490 500 510 520 530 540 RQDQYDCALW MMTFSSSIFL GLDIGLIISV VSAFFITTVR SHRAKILLLG QIPNTNIYRS 550 560 570 580 590 600 INDYREIITI PGVKIFQCCS SITFVNVYYL KHKLLKEVDM VKVPLKEEEI FSLFNSSDTN 610 620 630 640 650 660 LQGGKICRCF CNCDDLEPLP RILYTERFEN KLDPEASSIN LIHCSHFESM NTSQTASEDQ 670 680 690 700 710 720 VPYTVSSVSQ KNQGQQYEEV EEVWLPNNSS RNSSPGLPDV AESQGRRSLI PYSDASLLPS 730 740 750 760 VHTIILDFSM VHYVDSRGLV VLRQVSTEEA LAGALIPLLP SQPHPDPD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling." Toure A., Morin L., Pineau C., Becq F., Dorseuil O., Gacon G. J. Biol. Chem. 276:20309-20315(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH RACGAP1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, GLYCOSYLATION, VARIANT MET-73. Tissue: Testis.
[2]	"Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9." Lohi H., Kujala M., Maekelae S., Lehtonen E., Kestilae M., Saarialho-Kere U., Markovich D., Kere J. J. Biol. Chem. 277:14246-14254(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INHIBITION.
[3]	"Cloning of human SLC26A8, a new member of the sulphate transporter gene family of anion transporter/exchangers." Mount D.B. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-73; VAL-148; ASN-230 AND VAL-639.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS MET-73 AND VAL-639. Tissue: Testis.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 450-768 (ISOFORM 4). Tissue: Testis.
[8]	"Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure." Makela S., Eklund R., Lahdetie J., Mikkola M., Hovatta O., Kere J. Mol. Hum. Reprod. 11:129-132(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MET-73; VAL-148; ASN-230 AND VAL-639, MUTAGENESIS OF PRO-914.
[9]	"The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse." Toure A., Lhuillier P., Gossen J.A., Kuil C.W., Lhote D., Jegou B., Escalier D., Gacon G. Hum. Mol. Genet. 16:1783-1793(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF331522 mRNA. Translation: AAK95666.1. AF314959 mRNA. Translation: AAL26868.1. AF403499 mRNA. Translation: AAO26699.1. AL133507, Z95152 Genomic DNA. Translation: CAI40884.1. Z95152, AL133507 Genomic DNA. Translation: CAI19692.1. AL133507 Genomic DNA. Translation: CAI40882.1. CH471081 Genomic DNA. Translation: EAX03862.1. BC025408 mRNA. Translation: AAH25408.1. AK057276 mRNA. Translation: BAB71408.1. Different initiation.
IPI	IPI00066333. IPI00290911. IPI00885155. IPI00885156.
RefSeq	NP_001180405.1. NM_001193476.1. NP_443193.1. NM_052961.3. NP_619732.2. NM_138718.2.
UniGene	Hs.435836.
3D structure databases
ProteinModelPortal	Q96RN1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96RN1. 2 interactions.
STRING	9606.ENSP00000347778.
PTM databases
PhosphoSite	Q96RN1.
Polymorphism databases
DMDM	74761075.
Proteomic databases
PaxDb	Q96RN1.
PRIDE	Q96RN1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000355574; ENSP00000347778; ENSG00000112053. ENST00000394602; ENSP00000378100; ENSG00000112053. ENST00000490799; ENSP00000417638; ENSG00000112053.
GeneID	116369.
KEGG	hsa:116369.
UCSC	uc003olk.3. human. uc003oll.3. human. uc003olm.3. human.
Organism-specific databases
CTD	116369.
GeneCards	GC06M035911.
HGNC	HGNC:14468. SLC26A8.
HPA	HPA038080. HPA038081.
MIM	608480. gene.
neXtProt	NX_Q96RN1.
PharmGKB	PA37885.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0659.
HOGENOM	HOG000154234.
HOVERGEN	HBG108443.
InParanoid	Q96RN1.
KO	K14705.
OMA	QLIPPLN.
OrthoDB	EOG495ZR3.
PhylomeDB	Q96RN1.
Gene expression databases
ArrayExpress	Q96RN1.
Bgee	Q96RN1.
CleanEx	HS_SLC26A8.
Genevestigator	Q96RN1.
Family and domain databases
Gene3D	3.30.750.24. 2 hits.
InterPro	IPR002645. STAS_dom. IPR011547. Sulph_transpt. [Graphical view]
Pfam	PF01740. STAS. 1 hit. PF00916. Sulfate_transp. 1 hit. [Graphical view]
SUPFAM	SSF52091. STAS. 1 hit.
PROSITE	PS01130. SLC26A. False negative. PS50801. STAS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	116369.
NextBio	79881.
SOURCE	Search...

Entry information

Entry name

S26A8_HUMAN

Accession

Primary (citable) accession number: Q96RN1
Secondary accession number(s): Q5JVR5 , Q812C7, Q8TC65, Q96MA0, Q96PK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.