Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q96RN1

- S26A8_HUMAN

UniProt

Q96RN1 - S26A8_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Testis anion transporter 1

Gene

SLC26A8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.3 Publications

Enzyme regulationi

Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters), gluconate, and by thiosulfate.

GO - Molecular functioni

  1. anion:anion antiporter activity Source: UniProtKB-KW
  2. chloride channel activity Source: UniProtKB
  3. oxalate transmembrane transporter activity Source: UniProtKB
  4. sulfate transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. anion transport Source: UniProtKB
  2. cell differentiation Source: UniProtKB-KW
  3. chloride transmembrane transport Source: GOC
  4. chloride transport Source: UniProtKB
  5. meiotic nuclear division Source: UniProtKB-KW
  6. multicellular organismal development Source: UniProtKB-KW
  7. oxalate transport Source: UniProtKB
  8. spermatogenesis Source: UniProtKB-KW
  9. sulfate transmembrane transport Source: GOC
  10. sulfate transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Anion exchange, Differentiation, Ion transport, Meiosis, Spermatogenesis, Transport

Protein family/group databases

TCDBi2.A.53.2.14. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis anion transporter 1
Alternative name(s):
Anion exchange transporter
Solute carrier family 26 member 8
Gene namesi
Name:SLC26A8Imported
Synonyms:TAT11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:14468. SLC26A8.

Subcellular locationi

Membrane 2 Publications; Multi-pass membrane protein 2 Publications
Note: Located at the annulus ring structure within the sperm cell.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9595CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence AnalysisAdd
BLAST
Topological domaini117 – 1193ExtracellularSequence Analysis
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Topological domaini141 – 1466CytoplasmicSequence Analysis
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Topological domaini168 – 20235ExtracellularSequence AnalysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence AnalysisAdd
BLAST
Topological domaini224 – 2329CytoplasmicSequence Analysis
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST
Topological domaini254 – 27017ExtracellularSequence AnalysisAdd
BLAST
Transmembranei271 – 29121HelicalSequence AnalysisAdd
BLAST
Topological domaini292 – 30716CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei308 – 32821HelicalSequence AnalysisAdd
BLAST
Topological domaini329 – 35527ExtracellularSequence AnalysisAdd
BLAST
Transmembranei356 – 37621HelicalSequence AnalysisAdd
BLAST
Topological domaini377 – 39216CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei393 – 41321HelicalSequence AnalysisAdd
BLAST
Topological domaini414 – 42916ExtracellularSequence AnalysisAdd
BLAST
Transmembranei430 – 45021HelicalSequence AnalysisAdd
BLAST
Topological domaini451 – 4522CytoplasmicSequence Analysis
Transmembranei453 – 47321HelicalSequence AnalysisAdd
BLAST
Topological domaini474 – 49724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei498 – 51821HelicalSequence AnalysisAdd
BLAST
Topological domaini519 – 970452CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Spermatogenic failure 3 (SPGF3) [MIM:606766]: A disorder characterized by primary infertility, sperm morphologic abnormalities, and moderate to severe asthenozoospermia, condition in which the percentage of progressively motile sperm is abnormally low.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871R → Q in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
VAR_070058
Natural varianti812 – 8121E → K in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
VAR_070059
Natural varianti954 – 9541R → C in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
VAR_070060

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi914 – 9141P → S: Not a cause of male infertility. 1 Publication

Organism-specific databases

MIMi606766. phenotype.
Orphaneti276234. Non-syndromic male infertility due to sperm motility disorder.
PharmGKBiPA37885.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 970970Testis anion transporter 1PRO_0000322586Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96RN1.
PRIDEiQ96RN1.

PTM databases

PhosphoSiteiQ96RN1.

Expressioni

Tissue specificityi

Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa.2 Publications

Inductioni

Repressed by tunicamycin, an inhibitor of N-glycosylation.1 Publication

Gene expression databases

BgeeiQ96RN1.
CleanExiHS_SLC26A8.
ExpressionAtlasiQ96RN1. baseline and differential.
GenevestigatoriQ96RN1.

Organism-specific databases

HPAiHPA038080.
HPA038081.

Interactioni

Subunit structurei

Interacts with RACGAP1. Interacts with CFTR.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CFTRP135692EBI-1792052,EBI-349854
RACGAP1Q9H0H52EBI-1792052,EBI-717233

Protein-protein interaction databases

BioGridi125501. 2 interactions.
IntActiQ96RN1. 2 interactions.
STRINGi9606.ENSP00000347778.

Structurei

3D structure databases

ProteinModelPortaliQ96RN1.
SMRiQ96RN1. Positions 710-799.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini543 – 795253STASPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni664 – 970307Interaction with RACGAP11 PublicationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000154234.
HOVERGENiHBG108443.
InParanoidiQ96RN1.
KOiK14705.
OMAiIFGSCHQ.
OrthoDBiEOG73BVBX.
PhylomeDBiQ96RN1.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR002645. STAS_dom.
IPR011547. Sulph_transpt.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 13 Publications (identifier: Q96RN1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQLERSAIS GFSSKSRRNS FAYDVKREVY NEETFQQEHK RKASSSGNMN
60 70 80 90 100
INITTFRHHV QCRCSWHRFL RCVLTIFPFL EWMCMYRLKD WLLGDLLAGI
110 120 130 140 150
SVGLVQVPQG LTLSLLARQL IPPLNIAYAA FCSSVIYVIF GSCHQMSIGS
160 170 180 190 200
FFLVSALLIN VLKVSPFNNG QLVMGSFVKN EFSAPSYLMG YNKSLSVVAT
210 220 230 240 250
TTFLTGIIQL IMGVLGLGFI ATYLPESAMS AYLAAVALHI MLSQLTFIFG
260 270 280 290 300
IMISFHAGPI SFFYDIINYC VALPKANSTS ILVFLTVVVA LRINKCIRIS
310 320 330 340 350
FNQYPIEFPM ELFLIIGFTV IANKISMATE TSQTLIDMIP YSFLLPVTPD
360 370 380 390 400
FSLLPKIILQ AFSLSLVSSF LLIFLGKKIA SLHNYSVNSN QDLIAIGLCN
410 420 430 440 450
VVSSFFRSCV FTGAIARTII QDKSGGRQQF ASLVGAGVML LLMVKMGHFF
460 470 480 490 500
YTLPNAVLAG IILSNVIPYL ETISNLPSLW RQDQYDCALW MMTFSSSIFL
510 520 530 540 550
GLDIGLIISV VSAFFITTVR SHRAKILLLG QIPNTNIYRS INDYREIITI
560 570 580 590 600
PGVKIFQCCS SITFVNVYYL KHKLLKEVDM VKVPLKEEEI FSLFNSSDTN
610 620 630 640 650
LQGGKICRCF CNCDDLEPLP RILYTERFEN KLDPEASSIN LIHCSHFESM
660 670 680 690 700
NTSQTASEDQ VPYTVSSVSQ KNQGQQYEEV EEVWLPNNSS RNSSPGLPDV
710 720 730 740 750
AESQGRRSLI PYSDASLLPS VHTIILDFSM VHYVDSRGLV VLRQICNAFQ
760 770 780 790 800
NANILILIAG CHSSIVRAFE RNDFFDAGIT KTQLFLSVHD AVLFALSRKV
810 820 830 840 850
IGSSELSIDE SETVIRETYS ETDKNDNSRY KMSSSFLGSQ KNVSPGFIKI
860 870 880 890 900
QQPVEEESEL DLELESEQEA GLGLDLDLDR ELEPEMEPKA ETETKTQTEM
910 920 930 940 950
EPQPETEPEM EPNPKSRPRA HTFPQQRYWP MYHPSMASTQ SQTQTRTWSV
960 970
ERRRHPMDSY SPEGNSNEDV
Length:970
Mass (Da):109,006
Last modified:December 1, 2001 - v1
Checksum:i7F932A9CFE3A9EC4
GO
Isoform 21 Publication (identifier: Q96RN1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-314: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:865
Mass (Da):97,353
Checksum:i95925D014048905D
GO
Isoform 31 Publication (identifier: Q96RN1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-419: Missing.
     420-428: IQDKSGGRQ → VSLQLALSP

Note: No experimental confirmation available.Curated

Show »
Length:552
Mass (Da):62,455
Checksum:iFBB6C75D929BB281
GO
Isoform 41 Publication (identifier: Q96RN1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     745-768: ICNAFQNANILILIAGCHSSIVRA → VSTEEALAGALIPLLPSQPHPDPD
     769-970: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:768
Mass (Da):85,680
Checksum:i2A3BD6BC6188401F
GO

Sequence cautioni

The sequence AAO26699.1 differs from that shown. Reason: Incorrectly indicated as originating from mouse.Curated
The sequence BAB71408.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1681N → D in AAL26868. 1 PublicationCurated
Sequence conflicti168 – 1681N → D in AAO26699. 1 PublicationCurated
Sequence conflicti560 – 5601S → C in AAL26868. 1 PublicationCurated
Sequence conflicti560 – 5601S → C in AAO26699. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731V → M Not a cause of male infertility. 4 Publications
Corresponds to variant rs743923 [ dbSNP | Ensembl ].
VAR_039464
Natural varianti87 – 871R → Q in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
VAR_070058
Natural varianti148 – 1481I → V Not a cause of male infertility. 2 Publications
Corresponds to variant rs17713154 [ dbSNP | Ensembl ].
VAR_039465
Natural varianti230 – 2301S → N Not a cause of male infertility. 2 Publications
Corresponds to variant rs17707331 [ dbSNP | Ensembl ].
VAR_039466
Natural varianti639 – 6391I → V Not a cause of male infertility. 4 Publications
Corresponds to variant rs2295852 [ dbSNP | Ensembl ].
VAR_039467
Natural varianti812 – 8121E → K in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
VAR_070059
Natural varianti954 – 9541R → C in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 Publication
VAR_070060

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 419418Missing in isoform 3. 1 PublicationVSP_052704Add
BLAST
Alternative sequencei210 – 314105Missing in isoform 2. 1 PublicationVSP_052705Add
BLAST
Alternative sequencei420 – 4289IQDKSGGRQ → VSLQLALSP in isoform 3. 1 PublicationVSP_052706
Alternative sequencei745 – 76824ICNAF…SIVRA → VSTEEALAGALIPLLPSQPH PDPD in isoform 4. 1 PublicationVSP_052707Add
BLAST
Alternative sequencei769 – 970202Missing in isoform 4. 1 PublicationVSP_052708Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331522 mRNA. Translation: AAK95666.1.
AF314959 mRNA. Translation: AAL26868.1.
AF403499 mRNA. Translation: AAO26699.1.
AL133507, Z95152 Genomic DNA. Translation: CAI40884.1.
Z95152, AL133507 Genomic DNA. Translation: CAI19692.1.
AL133507 Genomic DNA. Translation: CAI40882.1.
CH471081 Genomic DNA. Translation: EAX03862.1.
BC025408 mRNA. Translation: AAH25408.1.
AK057276 mRNA. Translation: BAB71408.1. Different initiation.
CCDSiCCDS4813.1. [Q96RN1-1]
CCDS4814.1. [Q96RN1-2]
RefSeqiNP_001180405.1. NM_001193476.1. [Q96RN1-1]
NP_443193.1. NM_052961.3. [Q96RN1-1]
NP_619732.2. NM_138718.2. [Q96RN1-2]
UniGeneiHs.435836.

Genome annotation databases

EnsembliENST00000355574; ENSP00000347778; ENSG00000112053. [Q96RN1-1]
ENST00000394602; ENSP00000378100; ENSG00000112053. [Q96RN1-2]
ENST00000490799; ENSP00000417638; ENSG00000112053. [Q96RN1-1]
GeneIDi116369.
KEGGihsa:116369.
UCSCiuc003olk.3. human. [Q96RN1-3]
uc003oll.3. human. [Q96RN1-2]
uc003olm.3. human. [Q96RN1-1]

Polymorphism databases

DMDMi74761075.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331522 mRNA. Translation: AAK95666.1 .
AF314959 mRNA. Translation: AAL26868.1 .
AF403499 mRNA. Translation: AAO26699.1 .
AL133507 , Z95152 Genomic DNA. Translation: CAI40884.1 .
Z95152 , AL133507 Genomic DNA. Translation: CAI19692.1 .
AL133507 Genomic DNA. Translation: CAI40882.1 .
CH471081 Genomic DNA. Translation: EAX03862.1 .
BC025408 mRNA. Translation: AAH25408.1 .
AK057276 mRNA. Translation: BAB71408.1 . Different initiation.
CCDSi CCDS4813.1. [Q96RN1-1 ]
CCDS4814.1. [Q96RN1-2 ]
RefSeqi NP_001180405.1. NM_001193476.1. [Q96RN1-1 ]
NP_443193.1. NM_052961.3. [Q96RN1-1 ]
NP_619732.2. NM_138718.2. [Q96RN1-2 ]
UniGenei Hs.435836.

3D structure databases

ProteinModelPortali Q96RN1.
SMRi Q96RN1. Positions 710-799.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125501. 2 interactions.
IntActi Q96RN1. 2 interactions.
STRINGi 9606.ENSP00000347778.

Protein family/group databases

TCDBi 2.A.53.2.14. the sulfate permease (sulp) family.

PTM databases

PhosphoSitei Q96RN1.

Polymorphism databases

DMDMi 74761075.

Proteomic databases

PaxDbi Q96RN1.
PRIDEi Q96RN1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355574 ; ENSP00000347778 ; ENSG00000112053 . [Q96RN1-1 ]
ENST00000394602 ; ENSP00000378100 ; ENSG00000112053 . [Q96RN1-2 ]
ENST00000490799 ; ENSP00000417638 ; ENSG00000112053 . [Q96RN1-1 ]
GeneIDi 116369.
KEGGi hsa:116369.
UCSCi uc003olk.3. human. [Q96RN1-3 ]
uc003oll.3. human. [Q96RN1-2 ]
uc003olm.3. human. [Q96RN1-1 ]

Organism-specific databases

CTDi 116369.
GeneCardsi GC06M035911.
HGNCi HGNC:14468. SLC26A8.
HPAi HPA038080.
HPA038081.
MIMi 606766. phenotype.
608480. gene.
neXtProti NX_Q96RN1.
Orphaneti 276234. Non-syndromic male infertility due to sperm motility disorder.
PharmGKBi PA37885.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0659.
GeneTreei ENSGT00760000119026.
HOGENOMi HOG000154234.
HOVERGENi HBG108443.
InParanoidi Q96RN1.
KOi K14705.
OMAi IFGSCHQ.
OrthoDBi EOG73BVBX.
PhylomeDBi Q96RN1.
TreeFami TF313784.

Miscellaneous databases

GeneWikii SLC26A8.
GenomeRNAii 116369.
NextBioi 79881.
PROi Q96RN1.
SOURCEi Search...

Gene expression databases

Bgeei Q96RN1.
CleanExi HS_SLC26A8.
ExpressionAtlasi Q96RN1. baseline and differential.
Genevestigatori Q96RN1.

Family and domain databases

Gene3Di 3.30.750.24. 2 hits.
InterProi IPR002645. STAS_dom.
IPR011547. Sulph_transpt.
[Graphical view ]
Pfami PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 2 hits.
PROSITEi PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling."
    Toure A., Morin L., Pineau C., Becq F., Dorseuil O., Gacon G.
    J. Biol. Chem. 276:20309-20315(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH RACGAP1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, GLYCOSYLATION, VARIANT MET-73.
    Tissue: Testis1 Publication.
  2. "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9."
    Lohi H., Kujala M., Maekelae S., Lehtonen E., Kestilae M., Saarialho-Kere U., Markovich D., Kere J.
    J. Biol. Chem. 277:14246-14254(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INHIBITION.
  3. "Cloning of human SLC26A8, a new member of the sulphate transporter gene family of anion transporter/exchangers."
    Mount D.B.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-73; VAL-148; ASN-230 AND VAL-639.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS MET-73 AND VAL-639.
    Tissue: TestisImported.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 450-768 (ISOFORM 4).
    Tissue: TestisImported.
  8. "The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation."
    Rode B., Dirami T., Bakouh N., Rizk-Rabin M., Norez C., Lhuillier P., Lores P., Jollivet M., Melin P., Zvetkova I., Bienvenu T., Becq F., Planelles G., Edelman A., Gacon G., Toure A.
    Hum. Mol. Genet. 21:1287-1298(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SPERM CAPACITATION, INTERACTION WITH CFTR.
  9. "Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure."
    Makela S., Eklund R., Lahdetie J., Mikkola M., Hovatta O., Kere J.
    Mol. Hum. Reprod. 11:129-132(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS MET-73; VAL-148; ASN-230 AND VAL-639, MUTAGENESIS OF PRO-914.
  10. "The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse."
    Toure A., Lhuillier P., Gossen J.A., Kuil C.W., Lhote D., Jegou B., Escalier D., Gacon G.
    Hum. Mol. Genet. 16:1783-1793(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  11. "Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia."
    Dirami T., Rode B., Jollivet M., Da Silva N., Escalier D., Gaitch N., Norez C., Tuffery P., Wolf J.P., Becq F., Ray P.F., Dulioust E., Gacon G., Bienvenu T., Toure A.
    Am. J. Hum. Genet. 92:760-766(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS SPGF3 GLN-87; LYS-812 AND CYS-954, CHARACTERIZATION OF VARIANTS SPGF3 GLN-87; LYS-812 AND CYS-954.

Entry informationi

Entry nameiS26A8_HUMAN
AccessioniPrimary (citable) accession number: Q96RN1
Secondary accession number(s): Q5JVR5
, Q812C7, Q8TC65, Q96MA0, Q96PK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3