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Q96RL6 (SIG11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sialic acid-binding Ig-like lectin 11

Short name=Sialic acid-binding lectin 11
Short name=Siglec-11
Gene names
Name:SIGLEC11
ORF Names:UNQ9222/PRO28718
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length698 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Subunit structure

Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. Ref.1

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.

Domain

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Post-translational modification

Phosphorylated on tyrosine residues.

Sequence similarities

Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.

Sequence caution

The sequence AAK72907.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAQ88502.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   LigandLectin
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96RL6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96RL6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     455-551: YPPQLLGPSC...SGSVFQLLPG → W

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 698671Sialic acid-binding Ig-like lectin 11
PRO_0000014951

Regions

Topological domain28 – 561534Extracellular Potential
Transmembrane562 – 58423Helical; Potential
Topological domain585 – 698114Cytoplasmic Potential
Domain31 – 134104Ig-like V-type
Domain159 – 24486Ig-like C2-type 1
Domain251 – 350100Ig-like C2-type 2
Domain355 – 45298Ig-like C2-type 3
Motif642 – 6476ITIM motif

Sites

Binding site1321Sialic acid By similarity

Amino acid modifications

Glycosylation551N-linked (GlcNAc...) Potential
Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation2621N-linked (GlcNAc...) Potential
Glycosylation3661N-linked (GlcNAc...) Potential
Glycosylation3751N-linked (GlcNAc...) Potential
Glycosylation4971N-linked (GlcNAc...) Potential
Glycosylation5151N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 186 By similarity
Disulfide bond54 ↔ 114 By similarity
Disulfide bond177 ↔ 228 By similarity
Disulfide bond287 ↔ 334 By similarity
Disulfide bond391 ↔ 436 By similarity

Natural variations

Alternative sequence455 – 55197YPPQL…QLLPG → W in isoform 2.
VSP_008764

Experimental info

Sequence conflict961E → A in AAQ88502. Ref.3
Sequence conflict3651A → G in AAQ88502. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 20, 2010. Version 2.
Checksum: 61CF0F530DCDD62F

FASTA69875,795
        10         20         30         40         50         60 
MVPGQAQPQS PEMLLLPLLL PVLGAGSLNK DPSYSLQVQR QVPVPEGLCV IVSCNLSYPR 

        70         80         90        100        110        120 
DGWDESTAAY GYWFKGRTSP KTGAPVATNN QSREVEMSTR DRFQLTGDPG KGSCSLVIRD 

       130        140        150        160        170        180 
AQREDEAWYF FRVERGSRVR HSFLSNAFFL KVTALTKKPD VYIPETLEPG QPVTVICVFN 

       190        200        210        220        230        240 
WAFKKCPAPS FSWTGAALSP RRTRPSTSHF SVLSFTPSPQ DHDTDLTCHV DFSRKGVSAQ 

       250        260        270        280        290        300 
RTVRLRVAYA PKDLIISISH DNTSALELQG NVIYLEVQKG QFLRLLCAAD SQPPATLSWV 

       310        320        330        340        350        360 
LQDRVLSSSH PWGPRTLGLE LRGVRAGDSG RYTCRAENRL GSQQQALDLS VQYPPENLRV 

       370        380        390        400        410        420 
MVSQANRTVL ENLGNGTSLP VLEGQSLRLV CVTHSSPPAR LSWTRWGQTV GPSQPSDPGV 

       430        440        450        460        470        480 
LELPPIQMEH EGEFTCHAQH PLGSQHVSLS LSVHYPPQLL GPSCSWEAEG LHCSCSSQAS 

       490        500        510        520        530        540 
PAPSLRWWLG EELLEGNSSQ GSFEVTPSSA GPWANSSLSL HGGLSSGLRL RCKAWNVHGA 

       550        560        570        580        590        600 
QSGSVFQLLP GKLEHGGGLG LGAALGAGVA ALLAFCSCLV VFRVKICRKE ARKRAAAEQD 

       610        620        630        640        650        660 
VPSTLGPISQ GHQHECSAGS SQDHPPPGAA TYTPGKGEEQ ELHYASLSFQ GLRLWEPADQ 

       670        680        690 
EAPSTTEYSE IKIHTGQPLR GPGFGLQLER EMSGMVPK 

« Hide

Isoform 2 [UniParc].

Checksum: 648623DDB469EA95
Show »

FASTA60265,818

References

« Hide 'large scale' references
[1]"Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia."
Angata T., Kerr S.C., Greaves D.R., Varki N.M., Crocker P.R., Varki A.
J. Biol. Chem. 277:24466-24474(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH PTPN6 AND PTPN11.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF337818 mRNA. Translation: AAK72907.1. Different initiation.
AC011452 Genomic DNA. No translation available.
AY358135 mRNA. Translation: AAQ88502.1. Different initiation.
CCDSCCDS12790.2. [Q96RL6-1]
CCDS46150.1. [Q96RL6-2]
RefSeqNP_001128635.1. NM_001135163.1. [Q96RL6-2]
NP_443116.2. NM_052884.2. [Q96RL6-1]
UniGeneHs.661852.

3D structure databases

ProteinModelPortalQ96RL6.
SMRQ96RL6. Positions 34-546.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125285. 2 interactions.
IntActQ96RL6. 5 interactions.
STRING9606.ENSP00000412361.

Protein family/group databases

MEROPSI43.001.

PTM databases

PhosphoSiteQ96RL6.

Polymorphism databases

DMDM294862467.

Proteomic databases

PaxDbQ96RL6.
PRIDEQ96RL6.

Protocols and materials databases

DNASU114132.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000426971; ENSP00000398891; ENSG00000161640. [Q96RL6-2]
ENST00000447370; ENSP00000412361; ENSG00000161640. [Q96RL6-1]
GeneID114132.
KEGGhsa:114132.
UCSCuc010ybh.2. human. [Q96RL6-1]
uc010ybi.2. human. [Q96RL6-2]

Organism-specific databases

CTD114132.
GeneCardsGC19M050456.
HGNCHGNC:15622. SIGLEC11.
HPAHPA060278.
MIM607157. gene.
neXtProtNX_Q96RL6.
PharmGKBPA38005.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG280582.
HOGENOMHOG000236324.
HOVERGENHBG036161.
InParanoidQ96RL6.
KOK06750.
OMAHECSAGS.
PhylomeDBQ96RL6.
TreeFamTF332441.

Gene expression databases

ArrayExpressQ96RL6.
BgeeQ96RL6.
CleanExHS_SIGLEC11.
GenevestigatorQ96RL6.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view]
PfamPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi114132.
NextBio79001.
PROQ96RL6.
SOURCESearch...

Entry information

Entry nameSIG11_HUMAN
AccessionPrimary (citable) accession number: Q96RL6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: April 20, 2010
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM