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Protein

Sialic acid-binding Ig-like lectin 11

Gene

SIGLEC11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei132 – 1321Sialic acidBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid-binding Ig-like lectin 11
Short name:
Sialic acid-binding lectin 11
Short name:
Siglec-11
Gene namesi
ORF Names:UNQ9222/PRO28718
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15622. SIGLEC11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 561534ExtracellularSequence AnalysisAdd
BLAST
Transmembranei562 – 58423HelicalSequence AnalysisAdd
BLAST
Topological domaini585 – 698114CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38005.

Polymorphism and mutation databases

BioMutaiSIGLEC11.
DMDMi294862467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 698671Sialic acid-binding Ig-like lectin 11PRO_0000014951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 186PROSITE-ProRule annotation
Disulfide bondi54 ↔ 114PROSITE-ProRule annotation
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi177 ↔ 228PROSITE-ProRule annotation
Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi287 ↔ 334PROSITE-ProRule annotation
Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi391 ↔ 436PROSITE-ProRule annotation
Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
Modified residuei668 – 6681PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine residues.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ96RL6.
PRIDEiQ96RL6.

PTM databases

PhosphoSiteiQ96RL6.

Expressioni

Tissue specificityi

Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.

Gene expression databases

BgeeiQ96RL6.
CleanExiHS_SIGLEC11.
ExpressionAtlasiQ96RL6. baseline and differential.
GenevisibleiQ96RL6. HS.

Organism-specific databases

HPAiHPA060278.

Interactioni

Subunit structurei

Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.1 Publication

Protein-protein interaction databases

BioGridi125285. 2 interactions.
IntActiQ96RL6. 5 interactions.
STRINGi9606.ENSP00000412361.

Structurei

3D structure databases

ProteinModelPortaliQ96RL6.
SMRiQ96RL6. Positions 34-546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 134104Ig-like V-typeAdd
BLAST
Domaini159 – 24486Ig-like C2-type 1Add
BLAST
Domaini251 – 350100Ig-like C2-type 2Add
BLAST
Domaini355 – 45298Ig-like C2-type 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi642 – 6476ITIM motif

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280582.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiQ96RL6.
KOiK06750.
OMAiHECSAGS.
PhylomeDBiQ96RL6.
TreeFamiTF332441.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96RL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPGQAQPQS PEMLLLPLLL PVLGAGSLNK DPSYSLQVQR QVPVPEGLCV
60 70 80 90 100
IVSCNLSYPR DGWDESTAAY GYWFKGRTSP KTGAPVATNN QSREVEMSTR
110 120 130 140 150
DRFQLTGDPG KGSCSLVIRD AQREDEAWYF FRVERGSRVR HSFLSNAFFL
160 170 180 190 200
KVTALTKKPD VYIPETLEPG QPVTVICVFN WAFKKCPAPS FSWTGAALSP
210 220 230 240 250
RRTRPSTSHF SVLSFTPSPQ DHDTDLTCHV DFSRKGVSAQ RTVRLRVAYA
260 270 280 290 300
PKDLIISISH DNTSALELQG NVIYLEVQKG QFLRLLCAAD SQPPATLSWV
310 320 330 340 350
LQDRVLSSSH PWGPRTLGLE LRGVRAGDSG RYTCRAENRL GSQQQALDLS
360 370 380 390 400
VQYPPENLRV MVSQANRTVL ENLGNGTSLP VLEGQSLRLV CVTHSSPPAR
410 420 430 440 450
LSWTRWGQTV GPSQPSDPGV LELPPIQMEH EGEFTCHAQH PLGSQHVSLS
460 470 480 490 500
LSVHYPPQLL GPSCSWEAEG LHCSCSSQAS PAPSLRWWLG EELLEGNSSQ
510 520 530 540 550
GSFEVTPSSA GPWANSSLSL HGGLSSGLRL RCKAWNVHGA QSGSVFQLLP
560 570 580 590 600
GKLEHGGGLG LGAALGAGVA ALLAFCSCLV VFRVKICRKE ARKRAAAEQD
610 620 630 640 650
VPSTLGPISQ GHQHECSAGS SQDHPPPGAA TYTPGKGEEQ ELHYASLSFQ
660 670 680 690
GLRLWEPADQ EAPSTTEYSE IKIHTGQPLR GPGFGLQLER EMSGMVPK
Length:698
Mass (Da):75,795
Last modified:April 20, 2010 - v2
Checksum:i61CF0F530DCDD62F
GO
Isoform 2 (identifier: Q96RL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-551: YPPQLLGPSC...SGSVFQLLPG → W

Show »
Length:602
Mass (Da):65,818
Checksum:i648623DDB469EA95
GO

Sequence cautioni

The sequence AAK72907.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAQ88502.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961E → A in AAQ88502 (PubMed:12975309).Curated
Sequence conflicti365 – 3651A → G in AAQ88502 (PubMed:12975309).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei455 – 55197YPPQL…QLLPG → W in isoform 2. CuratedVSP_008764Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337818 mRNA. Translation: AAK72907.1. Different initiation.
AC011452 Genomic DNA. No translation available.
AY358135 mRNA. Translation: AAQ88502.1. Different initiation.
CCDSiCCDS12790.2. [Q96RL6-1]
CCDS46150.1. [Q96RL6-2]
RefSeqiNP_001128635.1. NM_001135163.1. [Q96RL6-2]
NP_443116.2. NM_052884.2. [Q96RL6-1]
UniGeneiHs.661852.

Genome annotation databases

EnsembliENST00000426971; ENSP00000398891; ENSG00000161640. [Q96RL6-2]
ENST00000447370; ENSP00000412361; ENSG00000161640. [Q96RL6-1]
GeneIDi114132.
KEGGihsa:114132.
UCSCiuc010ybh.2. human. [Q96RL6-1]
uc010ybi.2. human. [Q96RL6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337818 mRNA. Translation: AAK72907.1. Different initiation.
AC011452 Genomic DNA. No translation available.
AY358135 mRNA. Translation: AAQ88502.1. Different initiation.
CCDSiCCDS12790.2. [Q96RL6-1]
CCDS46150.1. [Q96RL6-2]
RefSeqiNP_001128635.1. NM_001135163.1. [Q96RL6-2]
NP_443116.2. NM_052884.2. [Q96RL6-1]
UniGeneiHs.661852.

3D structure databases

ProteinModelPortaliQ96RL6.
SMRiQ96RL6. Positions 34-546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125285. 2 interactions.
IntActiQ96RL6. 5 interactions.
STRINGi9606.ENSP00000412361.

Protein family/group databases

MEROPSiI43.001.

PTM databases

PhosphoSiteiQ96RL6.

Polymorphism and mutation databases

BioMutaiSIGLEC11.
DMDMi294862467.

Proteomic databases

PaxDbiQ96RL6.
PRIDEiQ96RL6.

Protocols and materials databases

DNASUi114132.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000426971; ENSP00000398891; ENSG00000161640. [Q96RL6-2]
ENST00000447370; ENSP00000412361; ENSG00000161640. [Q96RL6-1]
GeneIDi114132.
KEGGihsa:114132.
UCSCiuc010ybh.2. human. [Q96RL6-1]
uc010ybi.2. human. [Q96RL6-2]

Organism-specific databases

CTDi114132.
GeneCardsiGC19M050457.
HGNCiHGNC:15622. SIGLEC11.
HPAiHPA060278.
MIMi607157. gene.
neXtProtiNX_Q96RL6.
PharmGKBiPA38005.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG280582.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiQ96RL6.
KOiK06750.
OMAiHECSAGS.
PhylomeDBiQ96RL6.
TreeFamiTF332441.

Miscellaneous databases

GenomeRNAii114132.
NextBioi79001.
PROiQ96RL6.
SOURCEiSearch...

Gene expression databases

BgeeiQ96RL6.
CleanExiHS_SIGLEC11.
ExpressionAtlasiQ96RL6. baseline and differential.
GenevisibleiQ96RL6. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia."
    Angata T., Kerr S.C., Greaves D.R., Varki N.M., Crocker P.R., Varki A.
    J. Biol. Chem. 277:24466-24474(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH PTPN6 AND PTPN11.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiSIG11_HUMAN
AccessioniPrimary (citable) accession number: Q96RL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: April 20, 2010
Last modified: June 24, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.