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Q96RL6

- SIG11_HUMAN

UniProt

Q96RL6 - SIG11_HUMAN

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Protein

Sialic acid-binding Ig-like lectin 11

Gene
SIGLEC11, UNQ9222/PRO28718
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei132 – 1321Sialic acid By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid-binding Ig-like lectin 11
Short name:
Sialic acid-binding lectin 11
Short name:
Siglec-11
Gene namesi
ORF Names:UNQ9222/PRO28718
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:15622. SIGLEC11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 561534Extracellular Reviewed predictionAdd
BLAST
Transmembranei562 – 58423Helical; Reviewed predictionAdd
BLAST
Topological domaini585 – 698114Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38005.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Chaini28 – 698671Sialic acid-binding Ig-like lectin 11PRO_0000014951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 186 By similarity
Disulfide bondi54 ↔ 114 By similarity
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi177 ↔ 228 By similarity
Glycosylationi262 – 2621N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi287 ↔ 334 By similarity
Glycosylationi366 – 3661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi375 – 3751N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi391 ↔ 436 By similarity
Glycosylationi497 – 4971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi515 – 5151N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated on tyrosine residues.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ96RL6.
PRIDEiQ96RL6.

PTM databases

PhosphoSiteiQ96RL6.

Expressioni

Tissue specificityi

Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.

Gene expression databases

ArrayExpressiQ96RL6.
BgeeiQ96RL6.
CleanExiHS_SIGLEC11.
GenevestigatoriQ96RL6.

Organism-specific databases

HPAiHPA060278.

Interactioni

Subunit structurei

Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.1 Publication

Protein-protein interaction databases

BioGridi125285. 2 interactions.
IntActiQ96RL6. 5 interactions.
STRINGi9606.ENSP00000412361.

Structurei

3D structure databases

ProteinModelPortaliQ96RL6.
SMRiQ96RL6. Positions 34-546.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 134104Ig-like V-typeAdd
BLAST
Domaini159 – 24486Ig-like C2-type 1Add
BLAST
Domaini251 – 350100Ig-like C2-type 2Add
BLAST
Domaini355 – 45298Ig-like C2-type 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi642 – 6476ITIM motif

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280582.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiQ96RL6.
KOiK06750.
OMAiHECSAGS.
PhylomeDBiQ96RL6.
TreeFamiTF332441.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96RL6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVPGQAQPQS PEMLLLPLLL PVLGAGSLNK DPSYSLQVQR QVPVPEGLCV    50
IVSCNLSYPR DGWDESTAAY GYWFKGRTSP KTGAPVATNN QSREVEMSTR 100
DRFQLTGDPG KGSCSLVIRD AQREDEAWYF FRVERGSRVR HSFLSNAFFL 150
KVTALTKKPD VYIPETLEPG QPVTVICVFN WAFKKCPAPS FSWTGAALSP 200
RRTRPSTSHF SVLSFTPSPQ DHDTDLTCHV DFSRKGVSAQ RTVRLRVAYA 250
PKDLIISISH DNTSALELQG NVIYLEVQKG QFLRLLCAAD SQPPATLSWV 300
LQDRVLSSSH PWGPRTLGLE LRGVRAGDSG RYTCRAENRL GSQQQALDLS 350
VQYPPENLRV MVSQANRTVL ENLGNGTSLP VLEGQSLRLV CVTHSSPPAR 400
LSWTRWGQTV GPSQPSDPGV LELPPIQMEH EGEFTCHAQH PLGSQHVSLS 450
LSVHYPPQLL GPSCSWEAEG LHCSCSSQAS PAPSLRWWLG EELLEGNSSQ 500
GSFEVTPSSA GPWANSSLSL HGGLSSGLRL RCKAWNVHGA QSGSVFQLLP 550
GKLEHGGGLG LGAALGAGVA ALLAFCSCLV VFRVKICRKE ARKRAAAEQD 600
VPSTLGPISQ GHQHECSAGS SQDHPPPGAA TYTPGKGEEQ ELHYASLSFQ 650
GLRLWEPADQ EAPSTTEYSE IKIHTGQPLR GPGFGLQLER EMSGMVPK 698
Length:698
Mass (Da):75,795
Last modified:April 20, 2010 - v2
Checksum:i61CF0F530DCDD62F
GO
Isoform 2 (identifier: Q96RL6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-551: YPPQLLGPSC...SGSVFQLLPG → W

Show »
Length:602
Mass (Da):65,818
Checksum:i648623DDB469EA95
GO

Sequence cautioni

The sequence AAK72907.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAQ88502.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei455 – 55197YPPQL…QLLPG → W in isoform 2. VSP_008764Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961E → A in AAQ88502. 1 Publication
Sequence conflicti365 – 3651A → G in AAQ88502. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF337818 mRNA. Translation: AAK72907.1. Different initiation.
AC011452 Genomic DNA. No translation available.
AY358135 mRNA. Translation: AAQ88502.1. Different initiation.
CCDSiCCDS12790.2. [Q96RL6-1]
CCDS46150.1. [Q96RL6-2]
RefSeqiNP_001128635.1. NM_001135163.1. [Q96RL6-2]
NP_443116.2. NM_052884.2. [Q96RL6-1]
UniGeneiHs.661852.

Genome annotation databases

EnsembliENST00000426971; ENSP00000398891; ENSG00000161640. [Q96RL6-2]
ENST00000447370; ENSP00000412361; ENSG00000161640. [Q96RL6-1]
GeneIDi114132.
KEGGihsa:114132.
UCSCiuc010ybh.2. human. [Q96RL6-1]
uc010ybi.2. human. [Q96RL6-2]

Polymorphism databases

DMDMi294862467.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF337818 mRNA. Translation: AAK72907.1 . Different initiation.
AC011452 Genomic DNA. No translation available.
AY358135 mRNA. Translation: AAQ88502.1 . Different initiation.
CCDSi CCDS12790.2. [Q96RL6-1 ]
CCDS46150.1. [Q96RL6-2 ]
RefSeqi NP_001128635.1. NM_001135163.1. [Q96RL6-2 ]
NP_443116.2. NM_052884.2. [Q96RL6-1 ]
UniGenei Hs.661852.

3D structure databases

ProteinModelPortali Q96RL6.
SMRi Q96RL6. Positions 34-546.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125285. 2 interactions.
IntActi Q96RL6. 5 interactions.
STRINGi 9606.ENSP00000412361.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q96RL6.

Polymorphism databases

DMDMi 294862467.

Proteomic databases

PaxDbi Q96RL6.
PRIDEi Q96RL6.

Protocols and materials databases

DNASUi 114132.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000426971 ; ENSP00000398891 ; ENSG00000161640 . [Q96RL6-2 ]
ENST00000447370 ; ENSP00000412361 ; ENSG00000161640 . [Q96RL6-1 ]
GeneIDi 114132.
KEGGi hsa:114132.
UCSCi uc010ybh.2. human. [Q96RL6-1 ]
uc010ybi.2. human. [Q96RL6-2 ]

Organism-specific databases

CTDi 114132.
GeneCardsi GC19M050456.
HGNCi HGNC:15622. SIGLEC11.
HPAi HPA060278.
MIMi 607157. gene.
neXtProti NX_Q96RL6.
PharmGKBi PA38005.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG280582.
HOGENOMi HOG000236324.
HOVERGENi HBG036161.
InParanoidi Q96RL6.
KOi K06750.
OMAi HECSAGS.
PhylomeDBi Q96RL6.
TreeFami TF332441.

Miscellaneous databases

GenomeRNAii 114132.
NextBioi 79001.
PROi Q96RL6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96RL6.
Bgeei Q96RL6.
CleanExi HS_SIGLEC11.
Genevestigatori Q96RL6.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia."
    Angata T., Kerr S.C., Greaves D.R., Varki N.M., Crocker P.R., Varki A.
    J. Biol. Chem. 277:24466-24474(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH PTPN6 AND PTPN11.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiSIG11_HUMAN
AccessioniPrimary (citable) accession number: Q96RL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: April 20, 2010
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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