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Q96RL6

- SIG11_HUMAN

UniProt

Q96RL6 - SIG11_HUMAN

Protein

Sialic acid-binding Ig-like lectin 11

Gene

SIGLEC11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei132 – 1321Sialic acidBy similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Lectin

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sialic acid-binding Ig-like lectin 11
    Short name:
    Sialic acid-binding lectin 11
    Short name:
    Siglec-11
    Gene namesi
    ORF Names:UNQ9222/PRO28718
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:15622. SIGLEC11.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38005.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 698671Sialic acid-binding Ig-like lectin 11PRO_0000014951Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 186PROSITE-ProRule annotation
    Disulfide bondi54 ↔ 114PROSITE-ProRule annotation
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi177 ↔ 228PROSITE-ProRule annotation
    Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi287 ↔ 334PROSITE-ProRule annotation
    Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi391 ↔ 436PROSITE-ProRule annotation
    Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated on tyrosine residues.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ96RL6.
    PRIDEiQ96RL6.

    PTM databases

    PhosphoSiteiQ96RL6.

    Expressioni

    Tissue specificityi

    Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.

    Gene expression databases

    ArrayExpressiQ96RL6.
    BgeeiQ96RL6.
    CleanExiHS_SIGLEC11.
    GenevestigatoriQ96RL6.

    Organism-specific databases

    HPAiHPA060278.

    Interactioni

    Subunit structurei

    Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.1 Publication

    Protein-protein interaction databases

    BioGridi125285. 2 interactions.
    IntActiQ96RL6. 5 interactions.
    STRINGi9606.ENSP00000412361.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96RL6.
    SMRiQ96RL6. Positions 34-546.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 561534ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini585 – 698114CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei562 – 58423HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 134104Ig-like V-typeAdd
    BLAST
    Domaini159 – 24486Ig-like C2-type 1Add
    BLAST
    Domaini251 – 350100Ig-like C2-type 2Add
    BLAST
    Domaini355 – 45298Ig-like C2-type 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi642 – 6476ITIM motif

    Domaini

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280582.
    HOGENOMiHOG000236324.
    HOVERGENiHBG036161.
    InParanoidiQ96RL6.
    KOiK06750.
    OMAiHECSAGS.
    PhylomeDBiQ96RL6.
    TreeFamiTF332441.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    IPR013151. Immunoglobulin.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    PF07679. I-set. 1 hit.
    PF00047. ig. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00408. IGc2. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96RL6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVPGQAQPQS PEMLLLPLLL PVLGAGSLNK DPSYSLQVQR QVPVPEGLCV    50
    IVSCNLSYPR DGWDESTAAY GYWFKGRTSP KTGAPVATNN QSREVEMSTR 100
    DRFQLTGDPG KGSCSLVIRD AQREDEAWYF FRVERGSRVR HSFLSNAFFL 150
    KVTALTKKPD VYIPETLEPG QPVTVICVFN WAFKKCPAPS FSWTGAALSP 200
    RRTRPSTSHF SVLSFTPSPQ DHDTDLTCHV DFSRKGVSAQ RTVRLRVAYA 250
    PKDLIISISH DNTSALELQG NVIYLEVQKG QFLRLLCAAD SQPPATLSWV 300
    LQDRVLSSSH PWGPRTLGLE LRGVRAGDSG RYTCRAENRL GSQQQALDLS 350
    VQYPPENLRV MVSQANRTVL ENLGNGTSLP VLEGQSLRLV CVTHSSPPAR 400
    LSWTRWGQTV GPSQPSDPGV LELPPIQMEH EGEFTCHAQH PLGSQHVSLS 450
    LSVHYPPQLL GPSCSWEAEG LHCSCSSQAS PAPSLRWWLG EELLEGNSSQ 500
    GSFEVTPSSA GPWANSSLSL HGGLSSGLRL RCKAWNVHGA QSGSVFQLLP 550
    GKLEHGGGLG LGAALGAGVA ALLAFCSCLV VFRVKICRKE ARKRAAAEQD 600
    VPSTLGPISQ GHQHECSAGS SQDHPPPGAA TYTPGKGEEQ ELHYASLSFQ 650
    GLRLWEPADQ EAPSTTEYSE IKIHTGQPLR GPGFGLQLER EMSGMVPK 698
    Length:698
    Mass (Da):75,795
    Last modified:April 20, 2010 - v2
    Checksum:i61CF0F530DCDD62F
    GO
    Isoform 2 (identifier: Q96RL6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         455-551: YPPQLLGPSC...SGSVFQLLPG → W

    Show »
    Length:602
    Mass (Da):65,818
    Checksum:i648623DDB469EA95
    GO

    Sequence cautioni

    The sequence AAK72907.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAQ88502.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 961E → A in AAQ88502. (PubMed:12975309)Curated
    Sequence conflicti365 – 3651A → G in AAQ88502. (PubMed:12975309)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei455 – 55197YPPQL…QLLPG → W in isoform 2. CuratedVSP_008764Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF337818 mRNA. Translation: AAK72907.1. Different initiation.
    AC011452 Genomic DNA. No translation available.
    AY358135 mRNA. Translation: AAQ88502.1. Different initiation.
    CCDSiCCDS12790.2. [Q96RL6-1]
    CCDS46150.1. [Q96RL6-2]
    RefSeqiNP_001128635.1. NM_001135163.1. [Q96RL6-2]
    NP_443116.2. NM_052884.2. [Q96RL6-1]
    UniGeneiHs.661852.

    Genome annotation databases

    EnsembliENST00000426971; ENSP00000398891; ENSG00000161640. [Q96RL6-2]
    ENST00000447370; ENSP00000412361; ENSG00000161640. [Q96RL6-1]
    GeneIDi114132.
    KEGGihsa:114132.
    UCSCiuc010ybh.2. human. [Q96RL6-1]
    uc010ybi.2. human. [Q96RL6-2]

    Polymorphism databases

    DMDMi294862467.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF337818 mRNA. Translation: AAK72907.1 . Different initiation.
    AC011452 Genomic DNA. No translation available.
    AY358135 mRNA. Translation: AAQ88502.1 . Different initiation.
    CCDSi CCDS12790.2. [Q96RL6-1 ]
    CCDS46150.1. [Q96RL6-2 ]
    RefSeqi NP_001128635.1. NM_001135163.1. [Q96RL6-2 ]
    NP_443116.2. NM_052884.2. [Q96RL6-1 ]
    UniGenei Hs.661852.

    3D structure databases

    ProteinModelPortali Q96RL6.
    SMRi Q96RL6. Positions 34-546.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125285. 2 interactions.
    IntActi Q96RL6. 5 interactions.
    STRINGi 9606.ENSP00000412361.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q96RL6.

    Polymorphism databases

    DMDMi 294862467.

    Proteomic databases

    PaxDbi Q96RL6.
    PRIDEi Q96RL6.

    Protocols and materials databases

    DNASUi 114132.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000426971 ; ENSP00000398891 ; ENSG00000161640 . [Q96RL6-2 ]
    ENST00000447370 ; ENSP00000412361 ; ENSG00000161640 . [Q96RL6-1 ]
    GeneIDi 114132.
    KEGGi hsa:114132.
    UCSCi uc010ybh.2. human. [Q96RL6-1 ]
    uc010ybi.2. human. [Q96RL6-2 ]

    Organism-specific databases

    CTDi 114132.
    GeneCardsi GC19M050456.
    HGNCi HGNC:15622. SIGLEC11.
    HPAi HPA060278.
    MIMi 607157. gene.
    neXtProti NX_Q96RL6.
    PharmGKBi PA38005.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG280582.
    HOGENOMi HOG000236324.
    HOVERGENi HBG036161.
    InParanoidi Q96RL6.
    KOi K06750.
    OMAi HECSAGS.
    PhylomeDBi Q96RL6.
    TreeFami TF332441.

    Miscellaneous databases

    GenomeRNAii 114132.
    NextBioi 79001.
    PROi Q96RL6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96RL6.
    Bgeei Q96RL6.
    CleanExi HS_SIGLEC11.
    Genevestigatori Q96RL6.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    IPR013151. Immunoglobulin.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    PF07679. I-set. 1 hit.
    PF00047. ig. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00408. IGc2. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia."
      Angata T., Kerr S.C., Greaves D.R., Varki N.M., Crocker P.R., Varki A.
      J. Biol. Chem. 277:24466-24474(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH PTPN6 AND PTPN11.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiSIG11_HUMAN
    AccessioniPrimary (citable) accession number: Q96RL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-13 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3