##gff-version 3 Q96RL1 UniProtKB Chain 1 719 . . . ID=PRO_0000097547;Note=BRCA1-A complex subunit RAP80 Q96RL1 UniProtKB Domain 80 99 . . . Note=UIM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00213 Q96RL1 UniProtKB Domain 105 124 . . . Note=UIM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00213 Q96RL1 UniProtKB Zinc finger 502 529 . . . Note=UBZ4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01256 Q96RL1 UniProtKB Region 1 101 . . . Note=Necessary for transcriptional repression Q96RL1 UniProtKB Region 1 30 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96RL1 UniProtKB Region 43 68 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96RL1 UniProtKB Region 93 152 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96RL1 UniProtKB Region 97 103 . . . Note=UIM-linker Q96RL1 UniProtKB Region 100 200 . . . Note=Necessary for interaction with NR6A1 N-terminus Q96RL1 UniProtKB Region 164 205 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96RL1 UniProtKB Region 270 400 . . . Note=AIR Q96RL1 UniProtKB Region 320 378 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96RL1 UniProtKB Region 391 422 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96RL1 UniProtKB Region 400 500 . . . Note=Necessary for interaction with NR6A1 C-terminus Q96RL1 UniProtKB Region 505 582 . . . Note=Zinc-finger-like region Q96RL1 UniProtKB Region 588 668 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96RL1 UniProtKB Motif 60 78 . . . Note=LR motif Q96RL1 UniProtKB Compositional bias 43 60 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96RL1 UniProtKB Compositional bias 120 152 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96RL1 UniProtKB Compositional bias 172 192 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96RL1 UniProtKB Compositional bias 358 378 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96RL1 UniProtKB Compositional bias 394 422 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96RL1 UniProtKB Compositional bias 610 641 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96RL1 UniProtKB Binding site 505 505 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01256 Q96RL1 UniProtKB Binding site 508 508 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01256 Q96RL1 UniProtKB Binding site 520 520 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01256 Q96RL1 UniProtKB Binding site 524 524 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01256 Q96RL1 UniProtKB Modified residue 29 29 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q96RL1 UniProtKB Modified residue 44 44 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231;Dbxref=PMID:17081983,PMID:19690332,PMID:20068231 Q96RL1 UniProtKB Modified residue 46 46 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:20068231;Dbxref=PMID:17081983,PMID:20068231 Q96RL1 UniProtKB Modified residue 101 101 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:17525341,ECO:0000269|PubMed:17525342,ECO:0007744|PubMed:23186163;Dbxref=PMID:17525341,PMID:17525342,PMID:23186163 Q96RL1 UniProtKB Modified residue 140 140 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:17525340,ECO:0007744|PubMed:23186163;Dbxref=PMID:17525340,PMID:23186163 Q96RL1 UniProtKB Modified residue 205 205 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17621610,ECO:0000269|PubMed:18519686;Dbxref=PMID:17621610,PMID:18519686 Q96RL1 UniProtKB Modified residue 379 379 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5PQK4 Q96RL1 UniProtKB Modified residue 402 402 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17525340,ECO:0000269|PubMed:17621610;Dbxref=PMID:17525340,PMID:17621610 Q96RL1 UniProtKB Modified residue 419 419 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17525340;Dbxref=PMID:17525340 Q96RL1 UniProtKB Modified residue 466 466 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q96RL1 UniProtKB Modified residue 627 627 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q96RL1 UniProtKB Modified residue 653 653 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q96RL1 UniProtKB Modified residue 677 677 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163 Q96RL1 UniProtKB Cross-link 20 20 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:25772364,ECO:0007744|PubMed:28112733;Dbxref=PMID:25218447,PMID:25772364,PMID:28112733 Q96RL1 UniProtKB Cross-link 31 31 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733 Q96RL1 UniProtKB Cross-link 75 75 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q96RL1 UniProtKB Cross-link 90 90 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q96RL1 UniProtKB Cross-link 188 188 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q96RL1 UniProtKB Cross-link 245 245 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q96RL1 UniProtKB Cross-link 382 382 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733 Q96RL1 UniProtKB Cross-link 387 387 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q96RL1 UniProtKB Cross-link 428 428 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q96RL1 UniProtKB Cross-link 544 544 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733 Q96RL1 UniProtKB Cross-link 559 559 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q96RL1 UniProtKB Cross-link 562 562 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25218447;Dbxref=PMID:25218447 Q96RL1 UniProtKB Cross-link 587 587 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q96RL1 UniProtKB Cross-link 607 607 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:25755297,ECO:0007744|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:28112733 Q96RL1 UniProtKB Cross-link 635 635 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q96RL1 UniProtKB Cross-link 642 642 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q96RL1 UniProtKB Cross-link 696 696 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q96RL1 UniProtKB Cross-link 697 697 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q96RL1 UniProtKB Alternative sequence 1 370 . . . ID=VSP_012933;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|Ref.2,ECO:0000303|Ref.3 Q96RL1 UniProtKB Alternative sequence 1 78 . . . ID=VSP_012932;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3 Q96RL1 UniProtKB Alternative sequence 120 152 . . . ID=VSP_037264;Note=In isoform 5. SCRPSDASATRSRPLATGPSSQSHQEKTTDSGL->VNMPCCKSLWRLISYIFDFCGVVVALGTSCSHL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q96RL1 UniProtKB Alternative sequence 153 719 . . . ID=VSP_037265;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q96RL1 UniProtKB Alternative sequence 234 399 . . . ID=VSP_012935;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q96RL1 UniProtKB Alternative sequence 371 400 . . . ID=VSP_012934;Note=In isoform 4. SKTKDFQESSIKSLKEKLLLEEEPTTSHGQ->MLPLPDLDLWPLDRLPSPIKRKPQTLGSLK;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|Ref.2,ECO:0000303|Ref.3 Q96RL1 UniProtKB Natural variant 15 15 . . . ID=VAR_051469;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18695986;Dbxref=dbSNP:rs13167812,PMID:18695986 Q96RL1 UniProtKB Natural variant 353 353 . . . ID=VAR_055328;Note=M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18695986;Dbxref=dbSNP:rs143282828,PMID:18695986 Q96RL1 UniProtKB Natural variant 435 435 . . . ID=VAR_051470;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18695986;Dbxref=dbSNP:rs3733876,PMID:18695986 Q96RL1 UniProtKB Natural variant 511 511 . . . ID=VAR_051471;Note=C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18695986;Dbxref=dbSNP:rs13360277,PMID:18695986 Q96RL1 UniProtKB Natural variant 596 596 . . . ID=VAR_051472;Note=G->E;Dbxref=dbSNP:rs10475633 Q96RL1 UniProtKB Mutagenesis 9 9 . . . Note=Does not affect symoylation%3B when associated with A-19%3B A-31%3B A-52 and A-61. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17698038;Dbxref=PMID:17698038 Q96RL1 UniProtKB Mutagenesis 19 19 . . . Note=Does not affect symoylation%3B when associated with A-9%3B A-31%3B A-52 and A-61. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17698038;Dbxref=PMID:17698038 Q96RL1 UniProtKB Mutagenesis 31 31 . . . Note=Does not affect symoylation%3B when associated with A-9%3B A-19%3B A-52 and A-61. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17698038;Dbxref=PMID:17698038 Q96RL1 UniProtKB Mutagenesis 52 52 . . . Note=Does not affect symoylation%3B when associated with A-9%3B A-19%3B A-31 and A-61. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17698038;Dbxref=PMID:17698038 Q96RL1 UniProtKB Mutagenesis 61 61 . . . Note=Does not affect symoylation%3B when associated with A-9%3B A-19%3B A-31 and A-52. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17698038;Dbxref=PMID:17698038 Q96RL1 UniProtKB Mutagenesis 81 81 . . . Note=Strongly reduces ubiquitin binding via UIM 1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24627472;Dbxref=PMID:24627472 Q96RL1 UniProtKB Mutagenesis 88 88 . . . Note=Impairs localization to DNA damages sites%3B when associated with A-92%3B S-113 and A-117. A->G%2CS;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17525340,ECO:0000269|PubMed:17525342,ECO:0000269|PubMed:17621610;Dbxref=PMID:17525340,PMID:17525342,PMID:17621610 Q96RL1 UniProtKB Mutagenesis 92 92 . . . Note=Impairs localization to DNA damages sites%3B when associated with S-88%3B S-113 and A-117. S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17525340,ECO:0000269|PubMed:17525342;Dbxref=PMID:17525340,PMID:17525342 Q96RL1 UniProtKB Mutagenesis 97 103 . . . Note=Impairs the selectivity for 'K-63'-linked ubiquitin. REVNSQE->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19328070;Dbxref=PMID:19328070 Q96RL1 UniProtKB Mutagenesis 97 103 . . . Note=Increases the selectivity for 'K-63'-linked ubiquitin. REVNSQE->AAAAAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19328070;Dbxref=PMID:19328070 Q96RL1 UniProtKB Mutagenesis 97 103 . . . Note=Impairs the selectivity for 'K-63'-linked ubiquitin. REVNSQE->AAAAAAAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19328070;Dbxref=PMID:19328070 Q96RL1 UniProtKB Mutagenesis 101 101 . . . Note=Slightly impairs the selectivity for 'K-63'-linked ubiquitin. S->A%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19328070;Dbxref=PMID:19328070 Q96RL1 UniProtKB Mutagenesis 113 113 . . . Note=Impairs ubiquitin-binding and localization to DNA damages sites%3B when associated with S-88%3B A-92 and A-117. A->G%2CS;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17525340,ECO:0000269|PubMed:17525342,ECO:0000269|PubMed:17621610;Dbxref=PMID:17525340,PMID:17525342,PMID:17621610 Q96RL1 UniProtKB Mutagenesis 117 117 . . . Note=Impairs ubiquitin-binding and localization to DNA damages sites%3B when associated with S-88%3B A-92 and S-113. S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17525340,ECO:0000269|PubMed:17525342;Dbxref=PMID:17525340,PMID:17525342 Q96RL1 UniProtKB Mutagenesis 205 205 . . . Note=Abolishes phosphorylation at this position. S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18519686;Dbxref=PMID:18519686 Q96RL1 UniProtKB Mutagenesis 508 508 . . . Note=Abolishes interaction with histone monoubiquitinated H2B without affecting the interaction with H2A. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19015238;Dbxref=PMID:19015238 Q96RL1 UniProtKB Sequence conflict 187 187 . . . Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96RL1 UniProtKB Sequence conflict 192 192 . . . Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96RL1 UniProtKB Sequence conflict 247 247 . . . Note=V->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96RL1 UniProtKB Sequence conflict 347 347 . . . Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96RL1 UniProtKB Sequence conflict 518 518 . . . Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96RL1 UniProtKB Sequence conflict 634 634 . . . Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96RL1 UniProtKB Sequence conflict 638 638 . . . Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96RL1 UniProtKB Sequence conflict 694 694 . . . Note=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96RL1 UniProtKB Beta strand 40 43 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2N9E Q96RL1 UniProtKB Helix 84 94 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2MKF Q96RL1 UniProtKB Helix 101 119 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2MKF