Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cbp/p300-interacting transactivator 4

Gene

CITED4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Names & Taxonomyi

Protein namesi
Recommended name:
Cbp/p300-interacting transactivator 4
Alternative name(s):
MSG1-related protein 2
Short name:
MRG-2
Gene namesi
Name:CITED4Imported
Synonyms:MRG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000179862.6
HGNCiHGNC:18696 CITED4
MIMi606815 gene
neXtProtiNX_Q96RK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi163732
OpenTargetsiENSG00000179862
PharmGKBiPA38643

Polymorphism and mutation databases

BioMutaiCITED4
DMDMi74732696

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002333091 – 184Cbp/p300-interacting transactivator 4Add BLAST184

Proteomic databases

MaxQBiQ96RK1
PaxDbiQ96RK1
PeptideAtlasiQ96RK1
PRIDEiQ96RK1
TopDownProteomicsiQ96RK1

Expressioni

Tissue specificityi

Expressed in most tissues examined with highest levels of expression in heart, liver, skeletal muscle and pancreas. Also expressed in bladder cell line ECV-304 and in various breast cancer cell lines. Also detected in both in situ and invasive breast tumors where its expression is down-regulated and mostly restricted to the cytoplasm of malignant epithelium. Down-regulation of expression is associated with elevated levels of HIF1A and increased tumor growth and angiogenesis.2 Publications

Gene expression databases

BgeeiENSG00000179862
CleanExiHS_CITED4
GenevisibleiQ96RK1 HS

Organism-specific databases

HPAiHPA056434

Interactioni

Subunit structurei

Interacts via its C-terminal region with the CH1 domain of CREBBP and EP300. Interacts with all TFAP2/AP-2 isoforms.1 Publication

Protein-protein interaction databases

BioGridi127875, 5 interactors
STRINGi9606.ENSP00000361721

Structurei

3D structure databases

ProteinModelPortaliQ96RK1
SMRiQ96RK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 125Pro-richSequence analysisAdd BLAST109

Sequence similaritiesi

Belongs to the CITED family.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IZSZ Eukaryota
ENOG4111C3F LUCA
GeneTreeiENSGT00530000063624
HOGENOMiHOG000231079
HOVERGENiHBG075182
InParanoidiQ96RK1
KOiK22528
OMAiSFQPFPA
OrthoDBiEOG091G11W9
PhylomeDBiQ96RK1
TreeFamiTF331915

Family and domain databases

InterProiView protein in InterPro
IPR007576 CITED
PANTHERiPTHR17045 PTHR17045, 1 hit
PfamiView protein in Pfam
PF04487 CITED, 1 hit

Sequencei

Sequence statusi: Complete.

Q96RK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADHLMLAEG YRLVQRPPSA AAAHGPHALR TLPPYAGPGL DSGLRPRGAP
60 70 80 90 100
LGPPPPRQPG ALAYGAFGPP SSFQPFPAVP PPAAGIAHLQ PVATPYPGRA
110 120 130 140 150
AAPPNAPGGP PGPQPAPSAA APPPPAHALG GMDAELIDEE ALTSLELELG
160 170 180
LHRVRELPEL FLGQSEFDCF SDLGSAPPAG SVSC
Length:184
Mass (Da):18,569
Last modified:December 1, 2001 - v1
Checksum:i6775E3F2F0C25F10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF362074 Genomic DNA Translation: AAK64235.1
AF466291 Genomic DNA Translation: AAL73989.1
BC052559 mRNA Translation: AAH52559.1
BC035496 mRNA Translation: AAH35496.1
CCDSiCCDS458.1
RefSeqiNP_597724.1, NM_133467.2
UniGeneiHs.355820

Genome annotation databases

EnsembliENST00000372638; ENSP00000361721; ENSG00000179862
GeneIDi163732
KEGGihsa:163732
UCSCiuc001cgj.4 human

Similar proteinsi

Entry informationi

Entry nameiCITE4_HUMAN
AccessioniPrimary (citable) accession number: Q96RK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health