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Protein

Cbp/p300-interacting transactivator 4

Gene

CITED4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cbp/p300-interacting transactivator 4
Alternative name(s):
MSG1-related protein 2
Short name:
MRG-2
Gene namesi
Name:CITED4Imported
Synonyms:MRG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18696. CITED4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38643.

Polymorphism and mutation databases

BioMutaiCITED4.
DMDMi74732696.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Cbp/p300-interacting transactivator 4PRO_0000233309Add
BLAST

Proteomic databases

MaxQBiQ96RK1.
PaxDbiQ96RK1.
PRIDEiQ96RK1.
TopDownProteomicsiQ96RK1.

Expressioni

Tissue specificityi

Expressed in most tissues examined with highest levels of expression in heart, liver, skeletal muscle and pancreas. Also expressed in bladder cell line ECV-304 and in various breast cancer cell lines. Also detected in both in situ and invasive breast tumors where its expression is down-regulated and mostly restricted to the cytoplasm of malignant epithelium. Down-regulation of expression is associated with elevated levels of HIF1A and increased tumor growth and angiogenesis.2 Publications

Gene expression databases

BgeeiQ96RK1.
CleanExiHS_CITED4.
GenevisibleiQ96RK1. HS.

Organism-specific databases

HPAiHPA056434.

Interactioni

Subunit structurei

Interacts via its C-terminal region with the CH1 domain of CREBBP and EP300. Interacts with all TFAP2/AP-2 isoforms.1 Publication

Protein-protein interaction databases

BioGridi127875. 4 interactions.
STRINGi9606.ENSP00000361721.

Structurei

3D structure databases

ProteinModelPortaliQ96RK1.
SMRiQ96RK1. Positions 135-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 125109Pro-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CITED family.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IZSZ. Eukaryota.
ENOG4111C3F. LUCA.
GeneTreeiENSGT00530000063624.
HOGENOMiHOG000231079.
HOVERGENiHBG075182.
InParanoidiQ96RK1.
OMAiSFQPFPA.
OrthoDBiEOG72NRRB.
PhylomeDBiQ96RK1.
TreeFamiTF331915.

Family and domain databases

InterProiIPR007576. CITED.
[Graphical view]
PANTHERiPTHR17045. PTHR17045. 1 hit.
PfamiPF04487. CITED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADHLMLAEG YRLVQRPPSA AAAHGPHALR TLPPYAGPGL DSGLRPRGAP
60 70 80 90 100
LGPPPPRQPG ALAYGAFGPP SSFQPFPAVP PPAAGIAHLQ PVATPYPGRA
110 120 130 140 150
AAPPNAPGGP PGPQPAPSAA APPPPAHALG GMDAELIDEE ALTSLELELG
160 170 180
LHRVRELPEL FLGQSEFDCF SDLGSAPPAG SVSC
Length:184
Mass (Da):18,569
Last modified:December 1, 2001 - v1
Checksum:i6775E3F2F0C25F10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF362074 Genomic DNA. Translation: AAK64235.1.
AF466291 Genomic DNA. Translation: AAL73989.1.
BC052559 mRNA. Translation: AAH52559.1.
BC035496 mRNA. Translation: AAH35496.1.
CCDSiCCDS458.1.
RefSeqiNP_597724.1. NM_133467.2.
UniGeneiHs.355820.

Genome annotation databases

EnsembliENST00000372638; ENSP00000361721; ENSG00000179862.
GeneIDi163732.
KEGGihsa:163732.
UCSCiuc001cgj.4. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF362074 Genomic DNA. Translation: AAK64235.1.
AF466291 Genomic DNA. Translation: AAL73989.1.
BC052559 mRNA. Translation: AAH52559.1.
BC035496 mRNA. Translation: AAH35496.1.
CCDSiCCDS458.1.
RefSeqiNP_597724.1. NM_133467.2.
UniGeneiHs.355820.

3D structure databases

ProteinModelPortaliQ96RK1.
SMRiQ96RK1. Positions 135-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127875. 4 interactions.
STRINGi9606.ENSP00000361721.

Polymorphism and mutation databases

BioMutaiCITED4.
DMDMi74732696.

Proteomic databases

MaxQBiQ96RK1.
PaxDbiQ96RK1.
PRIDEiQ96RK1.
TopDownProteomicsiQ96RK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372638; ENSP00000361721; ENSG00000179862.
GeneIDi163732.
KEGGihsa:163732.
UCSCiuc001cgj.4. human.

Organism-specific databases

CTDi163732.
GeneCardsiCITED4.
HGNCiHGNC:18696. CITED4.
HPAiHPA056434.
MIMi606815. gene.
neXtProtiNX_Q96RK1.
PharmGKBiPA38643.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZSZ. Eukaryota.
ENOG4111C3F. LUCA.
GeneTreeiENSGT00530000063624.
HOGENOMiHOG000231079.
HOVERGENiHBG075182.
InParanoidiQ96RK1.
OMAiSFQPFPA.
OrthoDBiEOG72NRRB.
PhylomeDBiQ96RK1.
TreeFamiTF331915.

Miscellaneous databases

ChiTaRSiCITED4. human.
GenomeRNAii163732.
NextBioi88391.
PROiQ96RK1.
SOURCEiSearch...

Gene expression databases

BgeeiQ96RK1.
CleanExiHS_CITED4.
GenevisibleiQ96RK1. HS.

Family and domain databases

InterProiIPR007576. CITED.
[Graphical view]
PANTHERiPTHR17045. PTHR17045. 1 hit.
PfamiPF04487. CITED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural and functional conservation of MRG family in system evolution."
    Zhuang D.Z., Chou Y.-T., Yang Y.-C.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2."
    Braganca J., Swingler T., Marques F.I.R., Jones T., Eloranta J.J., Hurst H.C., Shioda T., Bhattacharya S.
    J. Biol. Chem. 277:8559-8565(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH CREBBP; EP300 AND TFAP2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PancreasImported.
  4. "CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha."
    Fox S.B., Braganca J., Turley H., Campo L., Han C., Gatter K.C., Bhattacharya S., Harris A.L.
    Cancer Res. 64:6075-6081(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCITE4_HUMAN
AccessioniPrimary (citable) accession number: Q96RK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.