Q96RK1 (CITE4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cbp/p300-interacting transactivator 4

Alternative name(s):
MSG1-related protein 2
Short name=MRG-2

Gene names

Name:	CITED4
Synonyms:	MRG2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	184 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. Ref.2 Ref.4
Subunit structure	Interacts via its C-terminal region with the CH1 domain of CREBBP and EP300. Interacts with all TFAP2/AP-2 isoforms. Ref.2
Subcellular location	Nucleus. Cytoplasm Ref.2 Ref.4.
Tissue specificity	Expressed in most tissues examined with highest levels of expression in heart, liver, skeletal muscle and pancreas. Also expressed in bladder cell line ECV304 and in various breast cancer cell lines. Also detected in both in situ and invasive breast tumors where its expression is down-regulated and mostly restricted to the cytoplasm of malignant epithelium. Down-regulation of expression is associated with elevated levels of HIF1A and increased tumor growth and angiogenesis. Ref.2 Ref.4
Sequence similarities	Belongs to the CITED family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to estrogen stimulus Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transcription coactivator activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 184	184	Cbp/p300-interacting transactivator 4		PRO_0000233309
Regions
	Compositional bias	17 – 125	109	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q96RK1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 6775E3F2F0C25F10	FASTA	184	18,569
	10 20 30 40 50 60 MADHLMLAEG YRLVQRPPSA AAAHGPHALR TLPPYAGPGL DSGLRPRGAP LGPPPPRQPG 70 80 90 100 110 120 ALAYGAFGPP SSFQPFPAVP PPAAGIAHLQ PVATPYPGRA AAPPNAPGGP PGPQPAPSAA 130 140 150 160 170 180 APPPPAHALG GMDAELIDEE ALTSLELELG LHRVRELPEL FLGQSEFDCF SDLGSAPPAG SVSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural and functional conservation of MRG family in system evolution." Zhuang D.Z., Chou Y.-T., Yang Y.-C. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2." Braganca J., Swingler T., Marques F.I.R., Jones T., Eloranta J.J., Hurst H.C., Shioda T., Bhattacharya S. J. Biol. Chem. 277:8559-8565(2002) [PubMed: 11744733] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH CREBBP; EP300 AND TFAP2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[4]	"CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha." Fox S.B., Braganca J., Turley H., Campo L., Han C., Gatter K.C., Bhattacharya S., Harris A.L. Cancer Res. 64:6075-6081(2004) [PubMed: 15342390] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF362074 Genomic DNA. Translation: AAK64235.1. AF466291 Genomic DNA. Translation: AAL73989.1. BC052559 mRNA. Translation: AAH52559.1. BC035496 mRNA. Translation: AAH35496.1.
IPI	IPI00045365.
RefSeq	NP_597724.1. NM_133467.2.
UniGene	Hs.355820.
3D structure databases
ProteinModelPortal	Q96RK1.
SMR	Q96RK1. Positions 124-173.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96RK1.
Polymorphism databases
DMDM	74732696.
Proteomic databases
PRIDE	Q96RK1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372638; ENSP00000361721; ENSG00000179862.
GeneID	163732.
KEGG	hsa:163732.
UCSC	uc001cgj.1. human.
Organism-specific databases
CTD	163732.
GeneCards	GC01M041362.
H-InvDB	HIX0023632.
HGNC	HGNC:18696. CITED4.
MIM	606815. gene.
neXtProt	NX_Q96RK1.
PharmGKB	PA38643.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21507.
GeneTree	ENSGT00530000063624.
HOGENOM	HBG446829.
HOVERGEN	HBG075182.
InParanoid	Q96RK1.
OMA	AHLQPVA.
OrthoDB	EOG4WQ144.
PhylomeDB	Q96RK1.
Gene expression databases
ArrayExpress	Q96RK1.
Bgee	Q96RK1.
CleanEx	HS_CITED4.
Genevestigator	Q96RK1.
GermOnline	ENSG00000179862. Homo sapiens.
Family and domain databases
InterPro	IPR007576. CITED. [Graphical view]
PANTHER	PTHR17045. CITED. 1 hit.
Pfam	PF04487. CITED. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	88391.
SOURCE	Search...

Entry information

Entry name

CITE4_HUMAN

Accession

Primary (citable) accession number: Q96RK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.