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Reviewed, UniProtKB/Swiss-Prot Q96RK0 (CIC_HUMAN)

Last modified January 19, 2010. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein capicua homolog
Gene names
Name: CIC
Synonyms: KIAA0306
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1608 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Transcriptional repressor which may play a role in development of the central nervous system (CNS). Ref.1

Subunit structure

Interact with ATXN1 and ATXN1L By similarity.

Subcellular location

Nucleus Potential.

Tissue specificity

Expressed in fetal brain. Ref.5

Miscellaneous

Expressed in medulloblastoma, a pediatric brain tumor which may arise from the granule cell lineage.

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Sequence caution

The sequence AAD11988.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Molecular functionRepressor
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processregulation of transcription

Inferred from electronic annotation. Source: UniProtKB-KW

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CENPJQ9HC771EBI-945857,EBI-946194

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16081608Protein capicua homolog
PRO_0000048598

Regions

DNA binding200 – 26869HMG box
Region28 – 4619Interaction with ATXN1 By similarity
Compositional bias42 – 13897Pro-rich
Compositional bias508 – 1303796Pro-rich
Compositional bias1524 – 160178Pro-rich

Amino acid modifications

Modified residue1421Phosphoserine Ref.9
Modified residue1461Phosphoserine Ref.9
Modified residue1731Phosphoserine Ref.8
Modified residue2791Phosphoserine Ref.6
Modified residue4961Phosphoserine Ref.8
Modified residue7211Phosphoserine Ref.9 Ref.8
Modified residue9041Phosphoserine By similarity
Modified residue12911Phosphothreonine Ref.9
Modified residue12941Phosphoserine Ref.9
Modified residue13731Phosphoserine Ref.9 Ref.8 Ref.7
Modified residue13781Phosphoserine Ref.7
Modified residue13821Phosphoserine Ref.9 Ref.8 Ref.7
Modified residue13971Phosphoserine Ref.9 Ref.4
Modified residue14021Phosphoserine Ref.9
Modified residue14091Phosphoserine Ref.9 Ref.4
Modified residue14621Phosphoserine Ref.6

Natural variations

Natural variant1041E → K in a breast cancer sample; somatic mutation. Ref.10
VAR_035936
Natural variant6521A → T in a breast cancer sample; somatic mutation. Ref.10
VAR_035937
Natural variant9821S → G: dbSNP rs17339472. Ref.1 Ref.3
VAR_028302

Sequences

Sequence LengthMass (Da)Tools
Q96RK0-1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 355603C8BD67244E

FASTA1,608163,820
        10         20         30         40         50         60 
MYSAHRPLMP ASSAASRGLG MFVWTNVEPR SVAVFPWHSL VPFLAPSQPD PSVQPSEAQQ 

        70         80         90        100        110        120 
PASHPVASNQ SKEPAESAAV AHERPPGGTG SADPERPPGA TCPESPGPGP PHPLGVVESG 

       130        140        150        160        170        180 
KGPPPTTEEE ASGPPGEPRL DSETESDHDD AFLSIMSPEI QLPLPPGKRR TQSLSALPKE 

       190        200        210        220        230        240 
RDSSSEKDGR SPNKREKDHI RRPMNAFMIF SKRHRALVHQ RHPNQDNRTV SKILGEWWYA 

       250        260        270        280        290        300 
LGPKEKQKYH DLAFQVKEAH FKAHPDWKWC NKDRKKSSSE AKPTSLGLAG GHKETRERSM 

       310        320        330        340        350        360 
SETGTAAAPG VSSELLSVAA QTLLSSDTKA PGSSSCGAER LHTVGGPGSA RPRAFSHSGV 

       370        380        390        400        410        420 
HSLDGGEVDS QALQELTQMV SGPASYSGPK PSTQYGAPGP FAAPGEGGAL AATGRPPLLP 

       430        440        450        460        470        480 
TRASRSQRAA SEDMTSDEER MVICEEEGDD DVIADDGFGT TDIDLKCKER VTDSESGDSS 

       490        500        510        520        530        540 
GEDPEGNKGF GRKVFSPVIR SSFTHCRPPL DPEPPGPPDP PVAFGKGYGS APSSSASSPA 

       550        560        570        580        590        600 
SSSASAATSF SLGSGTFKAQ ESGQGSTAGP LRPPPPGAGG PATPSKATRF LPMDPATFRR 

       610        620        630        640        650        660 
KRPESVGGLE PPGPSVIAAP PSGGGNILQT LVLPPNKEEQ EGGGARVPSA PAPSLAYGAP 

       670        680        690        700        710        720 
AAPLSRPAAT MVTNVVRPVS STPVPIASKP FPTSGRAEAS PNDTAGARTE MGTGSRVPGG 

       730        740        750        760        770        780 
SPLGVSLVYS DKKSAAATSP APHLVAGPLL GTVGKAPATV TNLLVGTPGY GAPAPPAVQF 

       790        800        810        820        830        840 
IAQGAPGGGT TAGSGAGAGS GPNGPVPLGI LQPGALGKAG GITQVQYILP TLPQQLQVAP 

       850        860        870        880        890        900 
APAPAPGTKA AAPSGPAPTT SIRFTLPPGT STNGKVLAAT APTPGIPILQ SVPSAPPPKA 

       910        920        930        940        950        960 
QSVSPVQAPP PGGSAQLLPG KVLVPLAAPS MSVRGGGAGQ PLPLVSPPFS VPVQNGAQPP 

       970        980        990       1000       1010       1020 
SKIIQLTPVP VSTPSGLVPP LSPATLPGPT SQPQKVLLPS STRITYVQSA GGHALPLGTS 

      1030       1040       1050       1060       1070       1080 
PASSQAGTVT SYGPTSSVAL GFTSLGPSGP AFVQPLLSAG QAPLLAPGQV GVSPVPSPQL 

      1090       1100       1110       1120       1130       1140 
PPACAAPGGP VITAFYSGSP APTSSAPLAQ PSQAPPSLVY TVATSTTPPA ATILPKGPPA 

      1150       1160       1170       1180       1190       1200 
PATATPAPTS PFPSATAGSM TYSLVAPKAQ RPSPKAPQKV KAAIASIPVG SFEAGASGRP 

      1210       1220       1230       1240       1250       1260 
GPAPRQPLEP GPVREPTAPE SELEGQPTPP APPPLPETWT PTARSSPPLP PPAEERTSAK 

      1270       1280       1290       1300       1310       1320 
GPETMASKFP SSSSDWRVPG QGLENRGEPP TPPSPAPAPA VAPGGSSESS SGRAAGDTPE 

      1330       1340       1350       1360       1370       1380 
RKEAAGTGKK VKVRPPPLKK TFDSVDNRVL SEVDFEERFA ELPEFRPEEV LPSPTLQSLA 

      1390       1400       1410       1420       1430       1440 
TSPRAILGSY RKKRKNSTDL DSAPEDPTSP KRKMRRRSSC SSEPNTPKSA KCEGDIFTFD 

      1450       1460       1470       1480       1490       1500 
RTGTEAEDVL GELEYDKVPY SSLRRTLDQR RALVMQLFQD HGFFPSAQAT AAFQARYADI 

      1510       1520       1530       1540       1550       1560 
FPSKVCLQLK IREVRQKIMQ AATPTEQPPG AEAPLPVPPP TGTAAAPAPT PSPAGGPDPT 

      1570       1580       1590       1600 
SPSSDSGTAQ AAPPLPPPPE SGPGQPGWEG APQPSPPPPG PSTAATGR 

« Hide

References

« Hide 'large scale' references
[1]"CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons."
Lee C.-J., Chan W.-I., Cheung M., Cheng Y.-C., Appleby V.J., Orme A.T., Scotting P.J.
Brain Res. Mol. Brain Res. 106:151-156(2002) [PubMed: 12393275] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, VARIANT GLY-982.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed: 15057824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 158-1608, VARIANT GLY-982.
Tissue: Brain.
[4]"Large-scale characterization of HeLa cell nuclear phosphoproteins."
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1397 AND SER-1409, MASS SPECTROMETRY.
Tissue: Epithelium.
[5]"CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas."
Lee C.-J., Chan W.-I., Scotting P.J.
J. Neurooncol. 73:101-108(2005) [PubMed: 15981098] [Abstract]
Cited for: TISSUE SPECIFICITY, EXPRESSION IN MEDULLOBLASTOMA.
[6]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279 AND SER-1462, MASS SPECTROMETRY.
Tissue: Epithelium.
[7]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1373; SER-1378 AND SER-1382, MASS SPECTROMETRY.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173; SER-496; SER-721; SER-1373 AND SER-1382, MASS SPECTROMETRY.
[9]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142; SER-146; SER-721; THR-1291; SER-1294; SER-1373; SER-1382; SER-1397; SER-1402 AND SER-1409, MASS SPECTROMETRY.
Tissue: T-cell.
[10]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed: 16959974] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-104 AND THR-652.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF363689 mRNA. Translation: AAK73515.1.
AC006486 Genomic DNA. Translation: AAD11988.1. Sequence problems.
AB002304 mRNA. Translation: BAA20765.1.
IPIIPI00045360.
RefSeqNP_055940.3.
UniGeneHs.388236

3D structure databases

SMRQ96RK0. Positions 184-268.
ModBaseSearch...

Protein-protein interaction databases

IntActQ96RK0. 10 interactions.
STRINGQ96RK0.

PTM databases

PhosphoSiteQ96RK0.

Proteomic databases

PRIDEQ96RK0.

Genome annotation databases

EnsemblENST00000160740; ENSP00000160740; ENSG00000079432; Homo sapiens. [Genome view]
GeneID23152.
KEGGhsa:23152.
NMPDRfig|9606.3.peg.16553.
UCSCuc002otf.1. human.

Organism-specific databases

CTD23152.
GeneCardsGC19P047480.
H-InvDBHIX0015175.
HGNCHGNC:14214. CIC.
HPACAB026388.
MIM612082. gene.
PharmGKBPA26513.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG19104.
HOVERGENQ96RK0.
InParanoidQ96RK0.
OMAHREPEEA.
OrthoDBEOG9RBT6Q.
PhylomeDBQ96RK0.

Gene expression databases

ArrayExpressQ96RK0.
BgeeQ96RK0.
CleanExHS_CIC.
GenevestigatorQ96RK0.
GermOnlineENSG00000079432. Homo sapiens.

Family and domain databases

InterProIPR000910. HMG_HMG1/HMG2.
IPR009071. HMG_superfamily.
[Graphical view]
Gene3DG3DSA:1.10.30.10. HMG-box. 1 hit.
PfamPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio44481.
SOURCESearch...

Entry information

Entry nameCIC_HUMAN
AccessionPrimary (citable) accession number: Q96RK0
Secondary accession number(s): Q7LGI1, Q9UEG5, Q9Y6T1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 17, 2006
Last modified: January 19, 2010
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents