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Protein

Protein capicua homolog

Gene

CIC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor which may play a role in development of the central nervous system (CNS).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi200 – 268HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000079432-MONOMER.
SignaLinkiQ96RK0.
SIGNORiQ96RK0.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein capicua homolog
Gene namesi
Name:CIC
Synonyms:KIAA0306
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:14214. CIC.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23152.
OpenTargetsiENSG00000079432.
PharmGKBiPA26513.

Polymorphism and mutation databases

BioMutaiCIC.
DMDMi116241300.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485981 – 1608Protein capicua homologAdd BLAST1608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146PhosphoserineBy similarity1
Modified residuei173PhosphoserineCombined sources1
Modified residuei190Omega-N-methylarginineBy similarity1
Modified residuei277PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1
Modified residuei431PhosphoserineBy similarity1
Modified residuei436PhosphoserineBy similarity1
Modified residuei496PhosphoserineBy similarity1
Modified residuei700PhosphoserineCombined sources1
Modified residuei721PhosphoserineCombined sources1
Modified residuei739PhosphoserineCombined sources1
Modified residuei863Asymmetric dimethylarginineCombined sources1
Modified residuei934Omega-N-methylarginineBy similarity1
Modified residuei1268N6-acetyllysineBy similarity1
Modified residuei1291PhosphothreonineBy similarity1
Modified residuei1294PhosphoserineCombined sources1
Modified residuei1351PhosphoserineCombined sources1
Modified residuei1373PhosphoserineCombined sources1
Modified residuei1378PhosphoserineCombined sources1
Modified residuei1382PhosphoserineCombined sources1
Modified residuei1389PhosphoserineCombined sources1
Modified residuei1397PhosphoserineCombined sources1
Modified residuei1398PhosphothreonineCombined sources1
Modified residuei1402PhosphoserineCombined sources1
Modified residuei1409PhosphoserineCombined sources1
Modified residuei1595PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ96RK0.
MaxQBiQ96RK0.
PaxDbiQ96RK0.
PeptideAtlasiQ96RK0.
PRIDEiQ96RK0.

PTM databases

iPTMnetiQ96RK0.
PhosphoSitePlusiQ96RK0.

Expressioni

Tissue specificityi

Expressed in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000079432.
CleanExiHS_CIC.
ExpressionAtlasiQ96RK0. baseline and differential.
GenevisibleiQ96RK0. HS.

Organism-specific databases

HPAiCAB026388.
HPA044341.

Interactioni

Subunit structurei

Interacts with ATXN1 and ATXN1L.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542535EBI-945857,EBI-930964
CENPJQ9HC772EBI-945857,EBI-946194

Protein-protein interaction databases

BioGridi116767. 19 interactors.
DIPiDIP-49964N.
IntActiQ96RK0. 18 interactors.
MINTiMINT-2856152.
STRINGi9606.ENSP00000160740.

Structurei

Secondary structure

11608
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Helixi37 – 39Combined sources3
Beta strandi44 – 46Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M41NMR-A34-48[»]
4J2JX-ray2.50D/E/F28-48[»]
4J2LX-ray3.15C/D21-48[»]
ProteinModelPortaliQ96RK0.
SMRiQ96RK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 46Interaction with ATXN1By similarityAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 138Pro-richAdd BLAST97
Compositional biasi508 – 1303Pro-richAdd BLAST796
Compositional biasi1524 – 1601Pro-richAdd BLAST78

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ITBG. Eukaryota.
ENOG4111S7E. LUCA.
GeneTreeiENSGT00530000063757.
HOVERGENiHBG081174.
InParanoidiQ96RK0.
KOiK20225.
PhylomeDBiQ96RK0.
TreeFamiTF323412.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSAHRPLMP ASSAASRGLG MFVWTNVEPR SVAVFPWHSL VPFLAPSQPD
60 70 80 90 100
PSVQPSEAQQ PASHPVASNQ SKEPAESAAV AHERPPGGTG SADPERPPGA
110 120 130 140 150
TCPESPGPGP PHPLGVVESG KGPPPTTEEE ASGPPGEPRL DSETESDHDD
160 170 180 190 200
AFLSIMSPEI QLPLPPGKRR TQSLSALPKE RDSSSEKDGR SPNKREKDHI
210 220 230 240 250
RRPMNAFMIF SKRHRALVHQ RHPNQDNRTV SKILGEWWYA LGPKEKQKYH
260 270 280 290 300
DLAFQVKEAH FKAHPDWKWC NKDRKKSSSE AKPTSLGLAG GHKETRERSM
310 320 330 340 350
SETGTAAAPG VSSELLSVAA QTLLSSDTKA PGSSSCGAER LHTVGGPGSA
360 370 380 390 400
RPRAFSHSGV HSLDGGEVDS QALQELTQMV SGPASYSGPK PSTQYGAPGP
410 420 430 440 450
FAAPGEGGAL AATGRPPLLP TRASRSQRAA SEDMTSDEER MVICEEEGDD
460 470 480 490 500
DVIADDGFGT TDIDLKCKER VTDSESGDSS GEDPEGNKGF GRKVFSPVIR
510 520 530 540 550
SSFTHCRPPL DPEPPGPPDP PVAFGKGYGS APSSSASSPA SSSASAATSF
560 570 580 590 600
SLGSGTFKAQ ESGQGSTAGP LRPPPPGAGG PATPSKATRF LPMDPATFRR
610 620 630 640 650
KRPESVGGLE PPGPSVIAAP PSGGGNILQT LVLPPNKEEQ EGGGARVPSA
660 670 680 690 700
PAPSLAYGAP AAPLSRPAAT MVTNVVRPVS STPVPIASKP FPTSGRAEAS
710 720 730 740 750
PNDTAGARTE MGTGSRVPGG SPLGVSLVYS DKKSAAATSP APHLVAGPLL
760 770 780 790 800
GTVGKAPATV TNLLVGTPGY GAPAPPAVQF IAQGAPGGGT TAGSGAGAGS
810 820 830 840 850
GPNGPVPLGI LQPGALGKAG GITQVQYILP TLPQQLQVAP APAPAPGTKA
860 870 880 890 900
AAPSGPAPTT SIRFTLPPGT STNGKVLAAT APTPGIPILQ SVPSAPPPKA
910 920 930 940 950
QSVSPVQAPP PGGSAQLLPG KVLVPLAAPS MSVRGGGAGQ PLPLVSPPFS
960 970 980 990 1000
VPVQNGAQPP SKIIQLTPVP VSTPSGLVPP LSPATLPGPT SQPQKVLLPS
1010 1020 1030 1040 1050
STRITYVQSA GGHALPLGTS PASSQAGTVT SYGPTSSVAL GFTSLGPSGP
1060 1070 1080 1090 1100
AFVQPLLSAG QAPLLAPGQV GVSPVPSPQL PPACAAPGGP VITAFYSGSP
1110 1120 1130 1140 1150
APTSSAPLAQ PSQAPPSLVY TVATSTTPPA ATILPKGPPA PATATPAPTS
1160 1170 1180 1190 1200
PFPSATAGSM TYSLVAPKAQ RPSPKAPQKV KAAIASIPVG SFEAGASGRP
1210 1220 1230 1240 1250
GPAPRQPLEP GPVREPTAPE SELEGQPTPP APPPLPETWT PTARSSPPLP
1260 1270 1280 1290 1300
PPAEERTSAK GPETMASKFP SSSSDWRVPG QGLENRGEPP TPPSPAPAPA
1310 1320 1330 1340 1350
VAPGGSSESS SGRAAGDTPE RKEAAGTGKK VKVRPPPLKK TFDSVDNRVL
1360 1370 1380 1390 1400
SEVDFEERFA ELPEFRPEEV LPSPTLQSLA TSPRAILGSY RKKRKNSTDL
1410 1420 1430 1440 1450
DSAPEDPTSP KRKMRRRSSC SSEPNTPKSA KCEGDIFTFD RTGTEAEDVL
1460 1470 1480 1490 1500
GELEYDKVPY SSLRRTLDQR RALVMQLFQD HGFFPSAQAT AAFQARYADI
1510 1520 1530 1540 1550
FPSKVCLQLK IREVRQKIMQ AATPTEQPPG AEAPLPVPPP TGTAAAPAPT
1560 1570 1580 1590 1600
PSPAGGPDPT SPSSDSGTAQ AAPPLPPPPE SGPGQPGWEG APQPSPPPPG

PSTAATGR
Length:1,608
Mass (Da):163,820
Last modified:October 17, 2006 - v2
Checksum:i355603C8BD67244E
GO

Sequence cautioni

The sequence AAD11988 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035936104E → K in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_065090492R → W De novo variant found in a patient with mental retardation. 1 Publication1
Natural variantiVAR_035937652A → T in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs770323488dbSNPEnsembl.1
Natural variantiVAR_028302982S → G.2 PublicationsCorresponds to variant rs17339472dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363689 mRNA. Translation: AAK73515.1.
AC006486 Genomic DNA. Translation: AAD11988.1. Sequence problems.
AB002304 mRNA. Translation: BAA20765.1.
CCDSiCCDS12601.1.
RefSeqiNP_001291744.1. NM_001304815.1.
NP_055940.3. NM_015125.4.
UniGeneiHs.388236.

Genome annotation databases

EnsembliENST00000575354; ENSP00000458663; ENSG00000079432.
GeneIDi23152.
KEGGihsa:23152.
UCSCiuc002otf.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363689 mRNA. Translation: AAK73515.1.
AC006486 Genomic DNA. Translation: AAD11988.1. Sequence problems.
AB002304 mRNA. Translation: BAA20765.1.
CCDSiCCDS12601.1.
RefSeqiNP_001291744.1. NM_001304815.1.
NP_055940.3. NM_015125.4.
UniGeneiHs.388236.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M41NMR-A34-48[»]
4J2JX-ray2.50D/E/F28-48[»]
4J2LX-ray3.15C/D21-48[»]
ProteinModelPortaliQ96RK0.
SMRiQ96RK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116767. 19 interactors.
DIPiDIP-49964N.
IntActiQ96RK0. 18 interactors.
MINTiMINT-2856152.
STRINGi9606.ENSP00000160740.

PTM databases

iPTMnetiQ96RK0.
PhosphoSitePlusiQ96RK0.

Polymorphism and mutation databases

BioMutaiCIC.
DMDMi116241300.

Proteomic databases

EPDiQ96RK0.
MaxQBiQ96RK0.
PaxDbiQ96RK0.
PeptideAtlasiQ96RK0.
PRIDEiQ96RK0.

Protocols and materials databases

DNASUi23152.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000575354; ENSP00000458663; ENSG00000079432.
GeneIDi23152.
KEGGihsa:23152.
UCSCiuc002otf.1. human.

Organism-specific databases

CTDi23152.
DisGeNETi23152.
GeneCardsiCIC.
H-InvDBHIX0015175.
HIX0137483.
HGNCiHGNC:14214. CIC.
HPAiCAB026388.
HPA044341.
MIMi612082. gene.
neXtProtiNX_Q96RK0.
OpenTargetsiENSG00000079432.
PharmGKBiPA26513.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITBG. Eukaryota.
ENOG4111S7E. LUCA.
GeneTreeiENSGT00530000063757.
HOVERGENiHBG081174.
InParanoidiQ96RK0.
KOiK20225.
PhylomeDBiQ96RK0.
TreeFamiTF323412.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000079432-MONOMER.
SignaLinkiQ96RK0.
SIGNORiQ96RK0.

Miscellaneous databases

ChiTaRSiCIC. human.
GeneWikiiCIC_(gene).
GenomeRNAii23152.
PROiQ96RK0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079432.
CleanExiHS_CIC.
ExpressionAtlasiQ96RK0. baseline and differential.
GenevisibleiQ96RK0. HS.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCIC_HUMAN
AccessioniPrimary (citable) accession number: Q96RK0
Secondary accession number(s): Q7LGI1, Q9UEG5, Q9Y6T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Expressed in medulloblastoma, a pediatric brain tumor which may arise from the granule cell lineage.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.