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Q96RJ0

- TAAR1_HUMAN

UniProt

Q96RJ0 - TAAR1_HUMAN

Protein

Trace amine-associated receptor 1

Gene

TAAR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: GDB
    2. trace-amine receptor activity Source: InterPro

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: GDB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16983. Amine ligand-binding receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trace amine-associated receptor 1
    Short name:
    TaR-1
    Short name:
    Trace amine receptor 1
    Gene namesi
    Name:TAAR1
    Synonyms:TA1, TAR1, TRAR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:17734. TAAR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: GDB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134921784.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Trace amine-associated receptor 1PRO_0000070141Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 182PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ96RJ0.
    PaxDbiQ96RJ0.
    PRIDEiQ96RJ0.

    PTM databases

    PhosphoSiteiQ96RJ0.

    Expressioni

    Tissue specificityi

    Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestine. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle and spleen.

    Gene expression databases

    BgeeiQ96RJ0.
    CleanExiHS_TAAR1.
    GenevestigatoriQ96RJ0.

    Organism-specific databases

    HPAiCAB022754.

    Interactioni

    Protein-protein interaction databases

    BioGridi126416. 1 interaction.
    STRINGi9606.ENSP00000275216.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96RJ0.
    SMRiQ96RJ0. Positions 24-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 5913CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini81 – 9818ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 18831ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini210 – 25243CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 28714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 33931CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303390.
    HOGENOMiHOG000239243.
    HOVERGENiHBG106962.
    InParanoidiQ96RJ0.
    KOiK05051.
    OMAiCHNIINI.
    OrthoDBiEOG7HXCR8.
    PhylomeDBiQ96RJ0.
    TreeFamiTF343107.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR009133. TAAR1.
    IPR009132. TAAR_fam.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01831. TRACEAMINE1R.
    PR01830. TRACEAMINER.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96RJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMPFCHNIIN ISCVKNNWSN DVRASLYSLM VLIILTTLVG NLIVIVSISH    50
    FKQLHTPTNW LIHSMATVDF LLGCLVMPYS MVRSAEHCWY FGEVFCKIHT 100
    STDIMLSSAS IFHLSFISID RYYAVCDPLR YKAKMNILVI CVMIFISWSV 150
    PAVFAFGMIF LELNFKGAEE IYYKHVHCRG GCSVFFSKIS GVLTFMTSFY 200
    IPGSIMLCVY YRIYLIAKEQ ARLISDANQK LQIGLEMKNG ISQSKERKAV 250
    KTLGIVMGVF LICWCPFFIC TVMDPFLHYI IPPTLNDVLI WFGYLNSTFN 300
    PMVYAFFYPW FRKALKMMLF GKIFQKDSSR CKLFLELSS 339
    Length:339
    Mass (Da):39,092
    Last modified:December 1, 2001 - v1
    Checksum:i5E72FA61CEFAC0E0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 231R → C.
    Corresponds to variant rs8192618 [ dbSNP | Ensembl ].
    VAR_049445
    Natural varianti252 – 2521T → A.
    Corresponds to variant rs6926857 [ dbSNP | Ensembl ].
    VAR_049446

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF380185 Genomic DNA. Translation: AAK71236.1.
    AF200627 Genomic DNA. Translation: AAG17112.1.
    AY180374 mRNA. Translation: AAO22154.1.
    AL513524 Genomic DNA. Translation: CAH72104.1.
    BC101825 mRNA. Translation: AAI01826.1.
    BC112194 mRNA. Translation: AAI12195.1.
    CCDSiCCDS5158.1.
    RefSeqiNP_612200.1. NM_138327.1.
    UniGeneiHs.375030.

    Genome annotation databases

    EnsembliENST00000275216; ENSP00000275216; ENSG00000146399.
    GeneIDi134864.
    KEGGihsa:134864.
    UCSCiuc003qdm.1. human.

    Polymorphism databases

    DMDMi38258636.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF380185 Genomic DNA. Translation: AAK71236.1 .
    AF200627 Genomic DNA. Translation: AAG17112.1 .
    AY180374 mRNA. Translation: AAO22154.1 .
    AL513524 Genomic DNA. Translation: CAH72104.1 .
    BC101825 mRNA. Translation: AAI01826.1 .
    BC112194 mRNA. Translation: AAI12195.1 .
    CCDSi CCDS5158.1.
    RefSeqi NP_612200.1. NM_138327.1.
    UniGenei Hs.375030.

    3D structure databases

    ProteinModelPortali Q96RJ0.
    SMRi Q96RJ0. Positions 24-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126416. 1 interaction.
    STRINGi 9606.ENSP00000275216.

    Chemistry

    BindingDBi Q96RJ0.
    ChEMBLi CHEMBL5857.
    DrugBanki DB00182. Amphetamine.
    GuidetoPHARMACOLOGYi 364.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q96RJ0.

    Polymorphism databases

    DMDMi 38258636.

    Proteomic databases

    MaxQBi Q96RJ0.
    PaxDbi Q96RJ0.
    PRIDEi Q96RJ0.

    Protocols and materials databases

    DNASUi 134864.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000275216 ; ENSP00000275216 ; ENSG00000146399 .
    GeneIDi 134864.
    KEGGi hsa:134864.
    UCSCi uc003qdm.1. human.

    Organism-specific databases

    CTDi 134864.
    GeneCardsi GC06M132966.
    HGNCi HGNC:17734. TAAR1.
    HPAi CAB022754.
    MIMi 609333. gene.
    neXtProti NX_Q96RJ0.
    PharmGKBi PA134921784.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303390.
    HOGENOMi HOG000239243.
    HOVERGENi HBG106962.
    InParanoidi Q96RJ0.
    KOi K05051.
    OMAi CHNIINI.
    OrthoDBi EOG7HXCR8.
    PhylomeDBi Q96RJ0.
    TreeFami TF343107.

    Enzyme and pathway databases

    Reactomei REACT_16983. Amine ligand-binding receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii TAAR1.
    GenomeRNAii 134864.
    NextBioi 83435.
    PROi Q96RJ0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96RJ0.
    CleanExi HS_TAAR1.
    Genevestigatori Q96RJ0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR009133. TAAR1.
    IPR009132. TAAR_fam.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01831. TRACEAMINE1R.
    PR01830. TRACEAMINER.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor."
      Bunzow J.R., Sonders M.S., Arttamangkul S., Harrison L.M., Zhang G., Quigley D.I., Darland T., Suchland K.L., Pasumamula S., Kennedy J.L., Olson S.B., Magenis R.E., Amara S.G., Grandy D.K.
      Mol. Pharmacol. 60:1181-1188(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Placenta.
    6. "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors."
      Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C.
      Genomics 85:372-385(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiTAAR1_HUMAN
    AccessioniPrimary (citable) accession number: Q96RJ0
    Secondary accession number(s): Q2M1W5, Q3MIH8, Q5VUQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3