Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Trace amine-associated receptor 1

Gene

TAAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GDB
  • trace-amine receptor activity Source: GO_Central

GO - Biological processi

  • cAMP biosynthetic process Source: CACAO
  • G-protein coupled receptor signaling pathway Source: Reactome

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375280 Amine ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 1
Short name:
TaR-1
Short name:
Trace amine receptor 1
Gene namesi
Name:TAAR1
Synonyms:TA1, TAR1, TRAR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146399.1
HGNCiHGNC:17734 TAAR1
MIMi609333 gene
neXtProtiNX_Q96RJ0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 59CytoplasmicSequence analysisAdd BLAST13
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 98ExtracellularSequence analysisAdd BLAST18
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 136CytoplasmicSequence analysisAdd BLAST17
Transmembranei137 – 157Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini158 – 188ExtracellularSequence analysisAdd BLAST31
Transmembranei189 – 209Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini210 – 252CytoplasmicSequence analysisAdd BLAST43
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 287ExtracellularSequence analysisAdd BLAST14
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 339CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi134864
OpenTargetsiENSG00000146399
PharmGKBiPA134921784

Chemistry databases

ChEMBLiCHEMBL5857
DrugBankiDB00182 Amphetamine
DB01576 Dextroamphetamine
DB01577 Methamphetamine
DB06714 Propylhexedrine
GuidetoPHARMACOLOGYi364

Polymorphism and mutation databases

BioMutaiTAAR1
DMDMi38258636

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701411 – 339Trace amine-associated receptor 1Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96RJ0
PeptideAtlasiQ96RJ0
PRIDEiQ96RJ0

PTM databases

iPTMnetiQ96RJ0
PhosphoSitePlusiQ96RJ0

Expressioni

Tissue specificityi

Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestine. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle and spleen.

Gene expression databases

BgeeiENSG00000146399
CleanExiHS_TAAR1

Organism-specific databases

HPAiHPA055614

Interactioni

Protein-protein interaction databases

BioGridi1264161 interactor.
STRINGi9606.ENSP00000275216

Chemistry databases

BindingDBiQ96RJ0

Structurei

3D structure databases

ProteinModelPortaliQ96RJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139340
HOGENOMiHOG000239243
HOVERGENiHBG106962
InParanoidiQ96RJ0
KOiK05051
OMAiMVYAFFY
OrthoDBiEOG091G06VI
PhylomeDBiQ96RJ0
TreeFamiTF343107

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR009133 TAAR1
IPR009132 TAAR_fam
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01831 TRACEAMINE1R
PR01830 TRACEAMINER
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96RJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPFCHNIIN ISCVKNNWSN DVRASLYSLM VLIILTTLVG NLIVIVSISH
60 70 80 90 100
FKQLHTPTNW LIHSMATVDF LLGCLVMPYS MVRSAEHCWY FGEVFCKIHT
110 120 130 140 150
STDIMLSSAS IFHLSFISID RYYAVCDPLR YKAKMNILVI CVMIFISWSV
160 170 180 190 200
PAVFAFGMIF LELNFKGAEE IYYKHVHCRG GCSVFFSKIS GVLTFMTSFY
210 220 230 240 250
IPGSIMLCVY YRIYLIAKEQ ARLISDANQK LQIGLEMKNG ISQSKERKAV
260 270 280 290 300
KTLGIVMGVF LICWCPFFIC TVMDPFLHYI IPPTLNDVLI WFGYLNSTFN
310 320 330
PMVYAFFYPW FRKALKMMLF GKIFQKDSSR CKLFLELSS
Length:339
Mass (Da):39,092
Last modified:December 1, 2001 - v1
Checksum:i5E72FA61CEFAC0E0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04944523R → C. Corresponds to variant dbSNP:rs8192618Ensembl.1
Natural variantiVAR_049446252T → A. Corresponds to variant dbSNP:rs6926857Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380185 Genomic DNA Translation: AAK71236.1
AF200627 Genomic DNA Translation: AAG17112.1
AY180374 mRNA Translation: AAO22154.1
AL513524 Genomic DNA No translation available.
BC101825 mRNA Translation: AAI01826.1
BC112194 mRNA Translation: AAI12195.1
CCDSiCCDS5158.1
RefSeqiNP_612200.1, NM_138327.2
UniGeneiHs.375030

Genome annotation databases

EnsembliENST00000275216; ENSP00000275216; ENSG00000146399
GeneIDi134864
KEGGihsa:134864
UCSCiuc003qdm.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTAAR1_HUMAN
AccessioniPrimary (citable) accession number: Q96RJ0
Secondary accession number(s): Q2M1W5, Q3MIH8, Q5VUQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome