Q96RJ0 (TAAR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trace amine-associated receptor 1
Short name=TaR-1
Short name=Trace amine receptor 1

Gene names

Name:	TAAR1
Synonyms:	TA1, TAR1, TRAR1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase. Ref.6
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestine. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle and spleen.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred by curator Ref.6. Source: GDB plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Trace amine-associated receptor 1		PRO_0000070141
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 59	13	Cytoplasmic Potential
	Transmembrane	60 – 80	21	Helical; Name=2; Potential
	Topological domain	81 – 98	18	Extracellular Potential
	Transmembrane	99 – 119	21	Helical; Name=3; Potential
	Topological domain	120 – 136	17	Cytoplasmic Potential
	Transmembrane	137 – 157	21	Helical; Name=4; Potential
	Topological domain	158 – 188	31	Extracellular Potential
	Transmembrane	189 – 209	21	Helical; Name=5; Potential
	Topological domain	210 – 252	43	Cytoplasmic Potential
	Transmembrane	253 – 273	21	Helical; Name=6; Potential
	Topological domain	274 – 287	14	Extracellular Potential
	Transmembrane	288 – 308	21	Helical; Name=7; Potential
	Topological domain	309 – 339	31	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Glycosylation	17	1	N-linked (GlcNAc...) Potential
	Disulfide bond	96 ↔ 182		By similarity
Natural variations
	Natural variant	23	1	R → C. Corresponds to variant rs8192618 [ dbSNP | Ensembl ].		VAR_049445
	Natural variant	252	1	T → A. Corresponds to variant rs6926857 [ dbSNP | Ensembl ].		VAR_049446

Sequences

	Sequence		Length	Mass (Da)
	Q96RJ0 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 5E72FA61CEFAC0E0	FASTA	339	39,092
	10 20 30 40 50 60 MMPFCHNIIN ISCVKNNWSN DVRASLYSLM VLIILTTLVG NLIVIVSISH FKQLHTPTNW 70 80 90 100 110 120 LIHSMATVDF LLGCLVMPYS MVRSAEHCWY FGEVFCKIHT STDIMLSSAS IFHLSFISID 130 140 150 160 170 180 RYYAVCDPLR YKAKMNILVI CVMIFISWSV PAVFAFGMIF LELNFKGAEE IYYKHVHCRG 190 200 210 220 230 240 GCSVFFSKIS GVLTFMTSFY IPGSIMLCVY YRIYLIAKEQ ARLISDANQK LQIGLEMKNG 250 260 270 280 290 300 ISQSKERKAV KTLGIVMGVF LICWCPFFIC TVMDPFLHYI IPPTLNDVLI WFGYLNSTFN 310 320 330 PMVYAFFYPW FRKALKMMLF GKIFQKDSSR CKLFLELSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Trace amines: identification of a family of mammalian G protein-coupled receptors." Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R., Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S., Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A., Gerald C. Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001) [PubMed: 11459929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor." Bunzow J.R., Sonders M.S., Arttamangkul S., Harrison L.M., Zhang G., Quigley D.I., Darland T., Suchland K.L., Pasumamula S., Kennedy J.L., Olson S.B., Magenis R.E., Amara S.G., Grandy D.K. Mol. Pharmacol. 60:1181-1188(2001) [PubMed: 11723224] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Placenta.
[6]	"Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors." Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C. Genomics 85:372-385(2005) [PubMed: 15718104] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF380185 Genomic DNA. Translation: AAK71236.1. AF200627 Genomic DNA. Translation: AAG17112.1. AY180374 mRNA. Translation: AAO22154.1. AL513524 Genomic DNA. Translation: CAH72104.1. BC101825 mRNA. Translation: AAI01826.1. BC112194 mRNA. Translation: AAI12195.1.
IPI	IPI00045329.
RefSeq	NP_612200.1. NM_138327.1.
UniGene	Hs.375030.
3D structure databases
ProteinModelPortal	Q96RJ0.
SMR	Q96RJ0. Positions 18-319.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96RJ0.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	38258636.
Proteomic databases
PRIDE	Q96RJ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000275216; ENSP00000275216; ENSG00000146399.
GeneID	134864.
KEGG	hsa:134864.
UCSC	uc003qdm.1. human.
Organism-specific databases
CTD	134864.
GeneCards	GC06M132966.
H-InvDB	HIX0032855.
HGNC	HGNC:17734. TAAR1.
HPA	CAB022754.
MIM	609333. gene.
neXtProt	NX_Q96RJ0.
PharmGKB	PA134921784.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11291.
GeneTree	ENSGT00550000074214.
HOGENOM	HBG445348.
HOVERGEN	HBG106962.
InParanoid	Q96RJ0.
OMA	QKDSSRC.
OrthoDB	EOG4RV2RT.
PhylomeDB	Q96RJ0.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q96RJ0.
Bgee	Q96RJ0.
CleanEx	HS_TAAR1.
Genevestigator	Q96RJ0.
GermOnline	ENSG00000146399. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR009133. Trac_amin_rcpt_1. IPR009132. Trace_amine_rcpt. [Graphical view]
KO	K05051.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01831. TRACEAMINE1R. PR01830. TRACEAMINER.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00182. Amphetamine.
NextBio	83435.
SOURCE	Search...

Entry information

Entry name

TAAR1_HUMAN

Accession

Primary (citable) accession number: Q96RJ0
Secondary accession number(s): Q2M1W5, Q3MIH8, Q5VUQ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.