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Q96RJ0 (TAAR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trace amine-associated receptor 1

Short name=TaR-1
Short name=Trace amine receptor 1
Gene names
Name:TAAR1
Synonyms:TA1, TAR1, TRAR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase. Ref.6

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestine. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle and spleen.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Trace amine-associated receptor 1
PRO_0000070141

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 5913Cytoplasmic Potential
Transmembrane60 – 8021Helical; Name=2; Potential
Topological domain81 – 9818Extracellular Potential
Transmembrane99 – 11921Helical; Name=3; Potential
Topological domain120 – 13617Cytoplasmic Potential
Transmembrane137 – 15721Helical; Name=4; Potential
Topological domain158 – 18831Extracellular Potential
Transmembrane189 – 20921Helical; Name=5; Potential
Topological domain210 – 25243Cytoplasmic Potential
Transmembrane253 – 27321Helical; Name=6; Potential
Topological domain274 – 28714Extracellular Potential
Transmembrane288 – 30821Helical; Name=7; Potential
Topological domain309 – 33931Cytoplasmic Potential

Amino acid modifications

Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation171N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 182 By similarity

Natural variations

Natural variant231R → C.
Corresponds to variant rs8192618 [ dbSNP | Ensembl ].
VAR_049445
Natural variant2521T → A.
Corresponds to variant rs6926857 [ dbSNP | Ensembl ].
VAR_049446

Sequences

Sequence LengthMass (Da)Tools
Q96RJ0 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 5E72FA61CEFAC0E0

FASTA33939,092
        10         20         30         40         50         60 
MMPFCHNIIN ISCVKNNWSN DVRASLYSLM VLIILTTLVG NLIVIVSISH FKQLHTPTNW 

        70         80         90        100        110        120 
LIHSMATVDF LLGCLVMPYS MVRSAEHCWY FGEVFCKIHT STDIMLSSAS IFHLSFISID 

       130        140        150        160        170        180 
RYYAVCDPLR YKAKMNILVI CVMIFISWSV PAVFAFGMIF LELNFKGAEE IYYKHVHCRG 

       190        200        210        220        230        240 
GCSVFFSKIS GVLTFMTSFY IPGSIMLCVY YRIYLIAKEQ ARLISDANQK LQIGLEMKNG 

       250        260        270        280        290        300 
ISQSKERKAV KTLGIVMGVF LICWCPFFIC TVMDPFLHYI IPPTLNDVLI WFGYLNSTFN 

       310        320        330 
PMVYAFFYPW FRKALKMMLF GKIFQKDSSR CKLFLELSS 

« Hide

References

« Hide 'large scale' references
[1]"Trace amines: identification of a family of mammalian G protein-coupled receptors."
Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R., Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S., Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A., Gerald C.
Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor."
Bunzow J.R., Sonders M.S., Arttamangkul S., Harrison L.M., Zhang G., Quigley D.I., Darland T., Suchland K.L., Pasumamula S., Kennedy J.L., Olson S.B., Magenis R.E., Amara S.G., Grandy D.K.
Mol. Pharmacol. 60:1181-1188(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Placenta.
[6]"Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors."
Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C.
Genomics 85:372-385(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF380185 Genomic DNA. Translation: AAK71236.1.
AF200627 Genomic DNA. Translation: AAG17112.1.
AY180374 mRNA. Translation: AAO22154.1.
AL513524 Genomic DNA. Translation: CAH72104.1.
BC101825 mRNA. Translation: AAI01826.1.
BC112194 mRNA. Translation: AAI12195.1.
CCDSCCDS5158.1.
RefSeqNP_612200.1. NM_138327.1.
UniGeneHs.375030.

3D structure databases

ProteinModelPortalQ96RJ0.
SMRQ96RJ0. Positions 24-319.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126416. 1 interaction.
STRING9606.ENSP00000275216.

Chemistry

BindingDBQ96RJ0.
ChEMBLCHEMBL5857.
DrugBankDB00182. Amphetamine.
GuidetoPHARMACOLOGY364.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ96RJ0.

Polymorphism databases

DMDM38258636.

Proteomic databases

MaxQBQ96RJ0.
PaxDbQ96RJ0.
PRIDEQ96RJ0.

Protocols and materials databases

DNASU134864.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000275216; ENSP00000275216; ENSG00000146399.
GeneID134864.
KEGGhsa:134864.
UCSCuc003qdm.1. human.

Organism-specific databases

CTD134864.
GeneCardsGC06M132966.
HGNCHGNC:17734. TAAR1.
HPACAB022754.
MIM609333. gene.
neXtProtNX_Q96RJ0.
PharmGKBPA134921784.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG303390.
HOGENOMHOG000239243.
HOVERGENHBG106962.
InParanoidQ96RJ0.
KOK05051.
OMACHNIINI.
OrthoDBEOG7HXCR8.
PhylomeDBQ96RJ0.
TreeFamTF343107.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ96RJ0.
CleanExHS_TAAR1.
GenevestigatorQ96RJ0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009133. TAAR1.
IPR009132. TAAR_fam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01831. TRACEAMINE1R.
PR01830. TRACEAMINER.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAAR1.
GenomeRNAi134864.
NextBio83435.
PROQ96RJ0.
SOURCESearch...

Entry information

Entry nameTAAR1_HUMAN
AccessionPrimary (citable) accession number: Q96RJ0
Secondary accession number(s): Q2M1W5, Q3MIH8, Q5VUQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries