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Protein

Trace amine-associated receptor 1

Gene

TAAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB
  2. trace-amine receptor activity Source: InterPro

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16983. Amine ligand-binding receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 1
Short name:
TaR-1
Short name:
Trace amine receptor 1
Gene namesi
Name:TAAR1
Synonyms:TA1, TAR1, TRAR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17734. TAAR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 5913CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini81 – 9818ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei137 – 15721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini158 – 18831ExtracellularSequence AnalysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini210 – 25243CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini274 – 28714ExtracellularSequence AnalysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini309 – 33931CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134921784.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Trace amine-associated receptor 1PRO_0000070141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ96RJ0.
PaxDbiQ96RJ0.
PRIDEiQ96RJ0.

PTM databases

PhosphoSiteiQ96RJ0.

Expressioni

Tissue specificityi

Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestine. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle and spleen.

Gene expression databases

BgeeiQ96RJ0.
CleanExiHS_TAAR1.
GenevestigatoriQ96RJ0.

Organism-specific databases

HPAiHPA055614.

Interactioni

Protein-protein interaction databases

BioGridi126416. 1 interaction.
STRINGi9606.ENSP00000275216.

Structurei

3D structure databases

ProteinModelPortaliQ96RJ0.
SMRiQ96RJ0. Positions 24-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303390.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ96RJ0.
KOiK05051.
OMAiISCVKNN.
OrthoDBiEOG7HXCR8.
PhylomeDBiQ96RJ0.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009133. TAAR1.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01831. TRACEAMINE1R.
PR01830. TRACEAMINER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPFCHNIIN ISCVKNNWSN DVRASLYSLM VLIILTTLVG NLIVIVSISH
60 70 80 90 100
FKQLHTPTNW LIHSMATVDF LLGCLVMPYS MVRSAEHCWY FGEVFCKIHT
110 120 130 140 150
STDIMLSSAS IFHLSFISID RYYAVCDPLR YKAKMNILVI CVMIFISWSV
160 170 180 190 200
PAVFAFGMIF LELNFKGAEE IYYKHVHCRG GCSVFFSKIS GVLTFMTSFY
210 220 230 240 250
IPGSIMLCVY YRIYLIAKEQ ARLISDANQK LQIGLEMKNG ISQSKERKAV
260 270 280 290 300
KTLGIVMGVF LICWCPFFIC TVMDPFLHYI IPPTLNDVLI WFGYLNSTFN
310 320 330
PMVYAFFYPW FRKALKMMLF GKIFQKDSSR CKLFLELSS
Length:339
Mass (Da):39,092
Last modified:November 30, 2001 - v1
Checksum:i5E72FA61CEFAC0E0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231R → C.
Corresponds to variant rs8192618 [ dbSNP | Ensembl ].
VAR_049445
Natural varianti252 – 2521T → A.
Corresponds to variant rs6926857 [ dbSNP | Ensembl ].
VAR_049446

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380185 Genomic DNA. Translation: AAK71236.1.
AF200627 Genomic DNA. Translation: AAG17112.1.
AY180374 mRNA. Translation: AAO22154.1.
AL513524 Genomic DNA. Translation: CAH72104.1.
BC101825 mRNA. Translation: AAI01826.1.
BC112194 mRNA. Translation: AAI12195.1.
CCDSiCCDS5158.1.
RefSeqiNP_612200.1. NM_138327.1.
UniGeneiHs.375030.

Genome annotation databases

EnsembliENST00000275216; ENSP00000275216; ENSG00000146399.
GeneIDi134864.
KEGGihsa:134864.
UCSCiuc003qdm.1. human.

Polymorphism databases

DMDMi38258636.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380185 Genomic DNA. Translation: AAK71236.1.
AF200627 Genomic DNA. Translation: AAG17112.1.
AY180374 mRNA. Translation: AAO22154.1.
AL513524 Genomic DNA. Translation: CAH72104.1.
BC101825 mRNA. Translation: AAI01826.1.
BC112194 mRNA. Translation: AAI12195.1.
CCDSiCCDS5158.1.
RefSeqiNP_612200.1. NM_138327.1.
UniGeneiHs.375030.

3D structure databases

ProteinModelPortaliQ96RJ0.
SMRiQ96RJ0. Positions 24-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126416. 1 interaction.
STRINGi9606.ENSP00000275216.

Chemistry

BindingDBiQ96RJ0.
ChEMBLiCHEMBL5857.
DrugBankiDB00182. Amphetamine.
DB01576. Dextroamphetamine.
DB01577. Methamphetamine.
DB06714. Propylhexedrine.
GuidetoPHARMACOLOGYi364.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ96RJ0.

Polymorphism databases

DMDMi38258636.

Proteomic databases

MaxQBiQ96RJ0.
PaxDbiQ96RJ0.
PRIDEiQ96RJ0.

Protocols and materials databases

DNASUi134864.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275216; ENSP00000275216; ENSG00000146399.
GeneIDi134864.
KEGGihsa:134864.
UCSCiuc003qdm.1. human.

Organism-specific databases

CTDi134864.
GeneCardsiGC06M132966.
HGNCiHGNC:17734. TAAR1.
HPAiHPA055614.
MIMi609333. gene.
neXtProtiNX_Q96RJ0.
PharmGKBiPA134921784.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG303390.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ96RJ0.
KOiK05051.
OMAiISCVKNN.
OrthoDBiEOG7HXCR8.
PhylomeDBiQ96RJ0.
TreeFamiTF343107.

Enzyme and pathway databases

ReactomeiREACT_16983. Amine ligand-binding receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiTAAR1.
GenomeRNAii134864.
NextBioi83435.
PROiQ96RJ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ96RJ0.
CleanExiHS_TAAR1.
GenevestigatoriQ96RJ0.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009133. TAAR1.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01831. TRACEAMINE1R.
PR01830. TRACEAMINER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor."
    Bunzow J.R., Sonders M.S., Arttamangkul S., Harrison L.M., Zhang G., Quigley D.I., Darland T., Suchland K.L., Pasumamula S., Kennedy J.L., Olson S.B., Magenis R.E., Amara S.G., Grandy D.K.
    Mol. Pharmacol. 60:1181-1188(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Placenta.
  6. "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors."
    Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C.
    Genomics 85:372-385(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTAAR1_HUMAN
AccessioniPrimary (citable) accession number: Q96RJ0
Secondary accession number(s): Q2M1W5, Q3MIH8, Q5VUQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 6, 2003
Last sequence update: November 30, 2001
Last modified: March 3, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.