ID   TAAR9_HUMAN             Reviewed;         348 AA.
AC   Q96RI9;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 161.
DE   RecName: Full=Trace amine-associated receptor 9;
DE            Short=TaR-9;
DE            Short=Trace amine receptor 9;
DE   AltName: Full=Trace amine receptor 3;
DE            Short=TaR-3;
GN   Name=TAAR9; Synonyms=TA3, TAR3, TRAR3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11459929; DOI=10.1073/pnas.151105198;
RA   Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA   Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA   Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA   Gerald C.;
RT   "Trace amines: identification of a family of mammalian G protein-coupled
RT   receptors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT   "cDNA clones of human proteins involved in signal transduction sequenced by
RT   the Guthrie cDNA resource center (www.cdna.org).";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC       amines are biogenic amines present in very low levels in mammalian
CC       tissues. Although some trace amines have clearly defined roles as
CC       neurotransmitters in invertebrates, the extent to which they function
CC       as true neurotransmitters in vertebrates has remained speculative.
CC       Trace amines are likely to be involved in a variety of physiological
CC       functions that have yet to be fully understood.
CC   -!- INTERACTION:
CC       Q96RI9; Q8IVJ1: SLC41A1; NbExp=3; IntAct=EBI-12908048, EBI-12266234;
CC       Q96RI9; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-12908048, EBI-11988865;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF380189; AAK71240.1; -; Genomic_DNA.
DR   EMBL; AY183469; AAO24660.1; -; mRNA.
DR   CCDS; CCDS75520.1; -.
DR   RefSeq; NP_778227.3; NM_175057.3.
DR   AlphaFoldDB; Q96RI9; -.
DR   SMR; Q96RI9; -.
DR   BioGRID; 126415; 2.
DR   IntAct; Q96RI9; 2.
DR   STRING; 9606.ENSP00000424607; -.
DR   ChEMBL; CHEMBL4523911; -.
DR   GlyCosmos; Q96RI9; 2 sites, No reported glycans.
DR   GlyGen; Q96RI9; 2 sites.
DR   iPTMnet; Q96RI9; -.
DR   PhosphoSitePlus; Q96RI9; -.
DR   BioMuta; TAAR9; -.
DR   DMDM; 38258635; -.
DR   MassIVE; Q96RI9; -.
DR   PaxDb; 9606-ENSP00000424607; -.
DR   PeptideAtlas; Q96RI9; -.
DR   Antibodypedia; 72575; 129 antibodies from 22 providers.
DR   DNASU; 134860; -.
DR   Ensembl; ENST00000434551.3; ENSP00000424607.2; ENSG00000237110.3.
DR   GeneID; 134860; -.
DR   KEGG; hsa:134860; -.
DR   MANE-Select; ENST00000434551.3; ENSP00000424607.2; NM_175057.4; NP_778227.3.
DR   UCSC; uc032xme.2; human.
DR   AGR; HGNC:20977; -.
DR   CTD; 134860; -.
DR   GeneCards; TAAR9; -.
DR   HGNC; HGNC:20977; TAAR9.
DR   HPA; ENSG00000237110; Not detected.
DR   MIM; 608282; gene.
DR   neXtProt; NX_Q96RI9; -.
DR   OpenTargets; ENSG00000237110; -.
DR   PharmGKB; PA134931528; -.
DR   VEuPathDB; HostDB:ENSG00000237110; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000162919; -.
DR   HOGENOM; CLU_009579_11_0_1; -.
DR   InParanoid; Q96RI9; -.
DR   OMA; CVRGCQA; -.
DR   OrthoDB; 2901788at2759; -.
DR   PhylomeDB; Q96RI9; -.
DR   PathwayCommons; Q96RI9; -.
DR   Reactome; R-HSA-375280; Amine ligand-binding receptors.
DR   Reactome; R-HSA-418555; G alpha (s) signalling events.
DR   SignaLink; Q96RI9; -.
DR   BioGRID-ORCS; 134860; 9 hits in 293 CRISPR screens.
DR   GeneWiki; TAAR9; -.
DR   GenomeRNAi; 134860; -.
DR   Pharos; Q96RI9; Tbio.
DR   PRO; PR:Q96RI9; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q96RI9; Protein.
DR   Bgee; ENSG00000237110; Expressed in cortical plate.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; TAS:GDB.
DR   GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:GDB.
DR   CDD; cd15316; 7tmA_TAAR6_8_9; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR009132; TAAR_fam.
DR   PANTHER; PTHR24249; HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24249:SF79; TRACE AMINE-ASSOCIATED RECEPTOR 9; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01830; TRACEAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q96RI9; HS.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..348
FT                   /note="Trace amine-associated receptor 9"
FT                   /id="PRO_0000070181"
FT   TOPO_DOM        1..37
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..106
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..128
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        129..147
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        169..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..259
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        281..294
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        316..348
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        19
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        105..190
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         278
FT                   /note="A -> T (in dbSNP:rs9389004)"
FT                   /id="VAR_049449"
SQ   SEQUENCE   348 AA;  39016 MW;  D0C6484880A6F761 CRC64;
     MVNNFSQAEA VELCYKNVNE SCIKTPYSPG PRSILYAVLG FGAVLAAFGN LLVMIAILHF
     KQLHTPTNFL IASLACADFL VGVTVMPFST VRSVESCWYF GDSYCKFHTC FDTSFCFASL
     FHLCCISVDR YIAVTDPLTY PTKFTVSVSG ICIVLSWFFS VTYSFSIFYT GANEEGIEEL
     VVALTCVGGC QAPLNQNWVL LCFLLFFIPN VAMVFIYSKI FLVAKHQARK IESTASQAQS
     SSESYKERVA KRERKAAKTL GIAMAAFLVS WLPYLVDAVI DAYMNFITPP YVYEILVWCV
     YYNSAMNPLI YAFFYQWFGK AIKLIVSGKV LRTDSSTTNL FSEEVETD
//