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Q96RI9 (TAAR9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trace amine-associated receptor 9

Short name=TaR-9
Short name=Trace amine receptor 9
Alternative name(s):
Trace amine receptor 3
Short name=TaR-3
Gene names
Name:TAAR9
Synonyms:TA3, TAR3, TRAR3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Trace amine-associated receptor 9
PRO_0000070181

Regions

Topological domain1 – 3737Extracellular Potential
Transmembrane38 – 5821Helical; Name=1; Potential
Topological domain59 – 6810Cytoplasmic Potential
Transmembrane69 – 8921Helical; Name=2; Potential
Topological domain90 – 10617Extracellular Potential
Transmembrane107 – 12822Helical; Name=3; Potential
Topological domain129 – 14719Cytoplasmic Potential
Transmembrane148 – 16821Helical; Name=4; Potential
Topological domain169 – 19729Extracellular Potential
Transmembrane198 – 21821Helical; Name=5; Potential
Topological domain219 – 25941Cytoplasmic Potential
Transmembrane260 – 28021Helical; Name=6; Potential
Topological domain281 – 29414Extracellular Potential
Transmembrane295 – 31521Helical; Name=7; Potential
Topological domain316 – 34833Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation191N-linked (GlcNAc...) Potential
Disulfide bond105 ↔ 190 By similarity

Natural variations

Natural variant2781A → T.
Corresponds to variant rs9389004 [ dbSNP | Ensembl ].
VAR_049449

Sequences

Sequence LengthMass (Da)Tools
Q96RI9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: D0C6484880A6F761

FASTA34839,016
        10         20         30         40         50         60 
MVNNFSQAEA VELCYKNVNE SCIKTPYSPG PRSILYAVLG FGAVLAAFGN LLVMIAILHF 

        70         80         90        100        110        120 
KQLHTPTNFL IASLACADFL VGVTVMPFST VRSVESCWYF GDSYCKFHTC FDTSFCFASL 

       130        140        150        160        170        180 
FHLCCISVDR YIAVTDPLTY PTKFTVSVSG ICIVLSWFFS VTYSFSIFYT GANEEGIEEL 

       190        200        210        220        230        240 
VVALTCVGGC QAPLNQNWVL LCFLLFFIPN VAMVFIYSKI FLVAKHQARK IESTASQAQS 

       250        260        270        280        290        300 
SSESYKERVA KRERKAAKTL GIAMAAFLVS WLPYLVDAVI DAYMNFITPP YVYEILVWCV 

       310        320        330        340 
YYNSAMNPLI YAFFYQWFGK AIKLIVSGKV LRTDSSTTNL FSEEVETD 

« Hide

References

« Hide 'large scale' references
[1]"Trace amines: identification of a family of mammalian G protein-coupled receptors."
Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R., Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S., Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A., Gerald C.
Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF380189 Genomic DNA. Translation: AAK71240.1.
AY183469 mRNA. Translation: AAO24660.1.
RefSeqNP_778227.3. NM_175057.3.
UniGeneHs.434116.

3D structure databases

ProteinModelPortalQ96RI9.
SMRQ96RI9. Positions 38-311.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38258635.

Proteomic databases

PRIDEQ96RI9.

Protocols and materials databases

DNASU134860.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID134860.
KEGGhsa:134860.
UCSCuc011eci.2. human.

Organism-specific databases

CTD134860.
GeneCardsGC06P132903.
HGNCHGNC:20977. TAAR9.
MIM608282. gene.
neXtProtNX_Q96RI9.
PharmGKBPA134931528.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG106962.
KOK05051.
PhylomeDBQ96RI9.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_TAAR9.
GenevestigatorQ96RI9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAAR9.
GenomeRNAi134860.
NextBio83431.
PROQ96RI9.
SOURCESearch...

Entry information

Entry nameTAAR9_HUMAN
AccessionPrimary (citable) accession number: Q96RI9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries