Q96RI9 (TAAR9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trace amine-associated receptor 9
Short name=TaR-9
Short name=Trace amine receptor 9

Alternative name(s):
Trace amine receptor 3
Short name=TaR-3

Gene names

Name:	TAAR9
Synonyms:	TA3, TAR3, TRAR3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred by curator. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor activity Traceable author statement. Source: GDB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Trace amine-associated receptor 9		PRO_0000070181
Regions
	Topological domain	1 – 37	37	Extracellular Potential
	Transmembrane	38 – 58	21	Helical; Name=1; Potential
	Topological domain	59 – 68	10	Cytoplasmic Potential
	Transmembrane	69 – 89	21	Helical; Name=2; Potential
	Topological domain	90 – 106	17	Extracellular Potential
	Transmembrane	107 – 128	22	Helical; Name=3; Potential
	Topological domain	129 – 147	19	Cytoplasmic Potential
	Transmembrane	148 – 168	21	Helical; Name=4; Potential
	Topological domain	169 – 197	29	Extracellular Potential
	Transmembrane	198 – 218	21	Helical; Name=5; Potential
	Topological domain	219 – 259	41	Cytoplasmic Potential
	Transmembrane	260 – 280	21	Helical; Name=6; Potential
	Topological domain	281 – 294	14	Extracellular Potential
	Transmembrane	295 – 315	21	Helical; Name=7; Potential
	Topological domain	316 – 348	33	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	19	1	N-linked (GlcNAc...) Potential
	Disulfide bond	105 ↔ 190		By similarity
Natural variations
	Natural variant	278	1	A → T. Corresponds to variant rs9389004 [ dbSNP | Ensembl ].		VAR_049449

Sequences

	Sequence		Length	Mass (Da)
	Q96RI9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: D0C6484880A6F761	FASTA	348	39,016
	10 20 30 40 50 60 MVNNFSQAEA VELCYKNVNE SCIKTPYSPG PRSILYAVLG FGAVLAAFGN LLVMIAILHF 70 80 90 100 110 120 KQLHTPTNFL IASLACADFL VGVTVMPFST VRSVESCWYF GDSYCKFHTC FDTSFCFASL 130 140 150 160 170 180 FHLCCISVDR YIAVTDPLTY PTKFTVSVSG ICIVLSWFFS VTYSFSIFYT GANEEGIEEL 190 200 210 220 230 240 VVALTCVGGC QAPLNQNWVL LCFLLFFIPN VAMVFIYSKI FLVAKHQARK IESTASQAQS 250 260 270 280 290 300 SSESYKERVA KRERKAAKTL GIAMAAFLVS WLPYLVDAVI DAYMNFITPP YVYEILVWCV 310 320 330 340 YYNSAMNPLI YAFFYQWFGK AIKLIVSGKV LRTDSSTTNL FSEEVETD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Trace amines: identification of a family of mammalian G protein-coupled receptors." Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R., Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S., Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A., Gerald C. Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001) [PubMed: 11459929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF380189 Genomic DNA. Translation: AAK71240.1. AY183469 mRNA. Translation: AAO24660.1.
IPI	IPI00045310.
RefSeq	NP_778227.3. NM_175057.3.
UniGene	Hs.434116.
3D structure databases
ProteinModelPortal	Q96RI9.
SMR	Q96RI9. Positions 2-328.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	38258635.
Proteomic databases
PRIDE	Q96RI9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	134860.
KEGG	hsa:134860.
Organism-specific databases
CTD	134860.
GeneCards	GC06P132903.
H-InvDB	HIX0032857.
HGNC	HGNC:20977. TAAR9.
MIM	608282. gene.
neXtProt	NX_Q96RI9.
PharmGKB	PA134931528.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10899.
HOGENOM	HBG445348.
HOVERGEN	HBG106962.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q96RI9.
CleanEx	HS_TAAR9.
Genevestigator	Q96RI9.
GermOnline	ENSG00000188604. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR009132. Trace_amine_rcpt. [Graphical view]
KO	K05051.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01830. TRACEAMINER.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	83431.
SOURCE	Search...

Entry information

Entry name

TAAR9_HUMAN

Accession

Primary (citable) accession number: Q96RI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.