Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Trace amine-associated receptor 9

Gene

TAAR9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB
  2. trace-amine receptor activity Source: InterPro

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16983. Amine ligand-binding receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 9
Short name:
TaR-9
Short name:
Trace amine receptor 9
Alternative name(s):
Trace amine receptor 3
Short name:
TaR-3
Gene namesi
Name:TAAR9
Synonyms:TA3, TAR3, TRAR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20977. TAAR9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei38 – 5821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini59 – 6810CytoplasmicSequence Analysis
Transmembranei69 – 8921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini90 – 10617ExtracellularSequence AnalysisAdd
BLAST
Transmembranei107 – 12822Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini129 – 14719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei148 – 16821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini169 – 19729ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 25941CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei260 – 28021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini281 – 29414ExtracellularSequence AnalysisAdd
BLAST
Transmembranei295 – 31521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini316 – 34833CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931528.

Polymorphism and mutation databases

BioMutaiTAAR9.
DMDMi38258635.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Trace amine-associated receptor 9PRO_0000070181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi105 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ96RI9.

Expressioni

Gene expression databases

CleanExiHS_TAAR9.
GenevestigatoriQ96RI9.

Structurei

3D structure databases

ProteinModelPortaliQ96RI9.
SMRiQ96RI9. Positions 38-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118774.
HOVERGENiHBG106962.
InParanoidiQ96RI9.
KOiK05051.
PhylomeDBiQ96RI9.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNNFSQAEA VELCYKNVNE SCIKTPYSPG PRSILYAVLG FGAVLAAFGN
60 70 80 90 100
LLVMIAILHF KQLHTPTNFL IASLACADFL VGVTVMPFST VRSVESCWYF
110 120 130 140 150
GDSYCKFHTC FDTSFCFASL FHLCCISVDR YIAVTDPLTY PTKFTVSVSG
160 170 180 190 200
ICIVLSWFFS VTYSFSIFYT GANEEGIEEL VVALTCVGGC QAPLNQNWVL
210 220 230 240 250
LCFLLFFIPN VAMVFIYSKI FLVAKHQARK IESTASQAQS SSESYKERVA
260 270 280 290 300
KRERKAAKTL GIAMAAFLVS WLPYLVDAVI DAYMNFITPP YVYEILVWCV
310 320 330 340
YYNSAMNPLI YAFFYQWFGK AIKLIVSGKV LRTDSSTTNL FSEEVETD
Length:348
Mass (Da):39,016
Last modified:December 1, 2001 - v1
Checksum:iD0C6484880A6F761
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti278 – 2781A → T.
Corresponds to variant rs9389004 [ dbSNP | Ensembl ].
VAR_049449

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380189 Genomic DNA. Translation: AAK71240.1.
AY183469 mRNA. Translation: AAO24660.1.
CCDSiCCDS75520.1.
RefSeqiNP_778227.3. NM_175057.3.
UniGeneiHs.434116.

Genome annotation databases

EnsembliENST00000434551; ENSP00000424607; ENSG00000237110.
GeneIDi134860.
KEGGihsa:134860.
UCSCiuc011eci.2. human.

Polymorphism and mutation databases

BioMutaiTAAR9.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380189 Genomic DNA. Translation: AAK71240.1.
AY183469 mRNA. Translation: AAO24660.1.
CCDSiCCDS75520.1.
RefSeqiNP_778227.3. NM_175057.3.
UniGeneiHs.434116.

3D structure databases

ProteinModelPortaliQ96RI9.
SMRiQ96RI9. Positions 38-311.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiTAAR9.
DMDMi38258635.

Proteomic databases

PRIDEiQ96RI9.

Protocols and materials databases

DNASUi134860.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434551; ENSP00000424607; ENSG00000237110.
GeneIDi134860.
KEGGihsa:134860.
UCSCiuc011eci.2. human.

Organism-specific databases

CTDi134860.
GeneCardsiGC06P132903.
HGNCiHGNC:20977. TAAR9.
MIMi608282. gene.
neXtProtiNX_Q96RI9.
PharmGKBiPA134931528.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118774.
HOVERGENiHBG106962.
InParanoidiQ96RI9.
KOiK05051.
PhylomeDBiQ96RI9.

Enzyme and pathway databases

ReactomeiREACT_16983. Amine ligand-binding receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiTAAR9.
GenomeRNAii134860.
NextBioi83431.
PROiQ96RI9.
SOURCEiSearch...

Gene expression databases

CleanExiHS_TAAR9.
GenevestigatoriQ96RI9.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTAAR9_HUMAN
AccessioniPrimary (citable) accession number: Q96RI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: April 29, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.