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Q96RI9

- TAAR9_HUMAN

UniProt

Q96RI9 - TAAR9_HUMAN

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Protein
Trace amine-associated receptor 9
Gene
TAAR9, TA3, TAR3, TRAR3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB
  2. trace-amine receptor activity Source: InterPro

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16983. Amine ligand-binding receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 9
Short name:
TaR-9
Short name:
Trace amine receptor 9
Alternative name(s):
Trace amine receptor 3
Short name:
TaR-3
Gene namesi
Name:TAAR9
Synonyms:TA3, TAR3, TRAR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:20977. TAAR9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737Extracellular Reviewed prediction
Add
BLAST
Transmembranei38 – 5821Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini59 – 6810Cytoplasmic Reviewed prediction
Transmembranei69 – 8921Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini90 – 10617Extracellular Reviewed prediction
Add
BLAST
Transmembranei107 – 12822Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini129 – 14719Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei148 – 16821Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini169 – 19729Extracellular Reviewed prediction
Add
BLAST
Transmembranei198 – 21821Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini219 – 25941Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei260 – 28021Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini281 – 29414Extracellular Reviewed prediction
Add
BLAST
Transmembranei295 – 31521Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini316 – 34833Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931528.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Trace amine-associated receptor 9
PRO_0000070181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19 – 191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi105 ↔ 190 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ96RI9.

Expressioni

Gene expression databases

CleanExiHS_TAAR9.
GenevestigatoriQ96RI9.

Structurei

3D structure databases

ProteinModelPortaliQ96RI9.
SMRiQ96RI9. Positions 38-311.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106962.
KOiK05051.
PhylomeDBiQ96RI9.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RI9-1 [UniParc]FASTAAdd to Basket

« Hide

MVNNFSQAEA VELCYKNVNE SCIKTPYSPG PRSILYAVLG FGAVLAAFGN    50
LLVMIAILHF KQLHTPTNFL IASLACADFL VGVTVMPFST VRSVESCWYF 100
GDSYCKFHTC FDTSFCFASL FHLCCISVDR YIAVTDPLTY PTKFTVSVSG 150
ICIVLSWFFS VTYSFSIFYT GANEEGIEEL VVALTCVGGC QAPLNQNWVL 200
LCFLLFFIPN VAMVFIYSKI FLVAKHQARK IESTASQAQS SSESYKERVA 250
KRERKAAKTL GIAMAAFLVS WLPYLVDAVI DAYMNFITPP YVYEILVWCV 300
YYNSAMNPLI YAFFYQWFGK AIKLIVSGKV LRTDSSTTNL FSEEVETD 348
Length:348
Mass (Da):39,016
Last modified:December 1, 2001 - v1
Checksum:iD0C6484880A6F761
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti278 – 2781A → T.
Corresponds to variant rs9389004 [ dbSNP | Ensembl ].
VAR_049449

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF380189 Genomic DNA. Translation: AAK71240.1.
AY183469 mRNA. Translation: AAO24660.1.
RefSeqiNP_778227.3. NM_175057.3.
UniGeneiHs.434116.

Genome annotation databases

GeneIDi134860.
KEGGihsa:134860.
UCSCiuc011eci.2. human.

Polymorphism databases

DMDMi38258635.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF380189 Genomic DNA. Translation: AAK71240.1 .
AY183469 mRNA. Translation: AAO24660.1 .
RefSeqi NP_778227.3. NM_175057.3.
UniGenei Hs.434116.

3D structure databases

ProteinModelPortali Q96RI9.
SMRi Q96RI9. Positions 38-311.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38258635.

Proteomic databases

PRIDEi Q96RI9.

Protocols and materials databases

DNASUi 134860.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 134860.
KEGGi hsa:134860.
UCSCi uc011eci.2. human.

Organism-specific databases

CTDi 134860.
GeneCardsi GC06P132903.
HGNCi HGNC:20977. TAAR9.
MIMi 608282. gene.
neXtProti NX_Q96RI9.
PharmGKBi PA134931528.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG106962.
KOi K05051.
PhylomeDBi Q96RI9.

Enzyme and pathway databases

Reactomei REACT_16983. Amine ligand-binding receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikii TAAR9.
GenomeRNAii 134860.
NextBioi 83431.
PROi Q96RI9.
SOURCEi Search...

Gene expression databases

CleanExi HS_TAAR9.
Genevestigatori Q96RI9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTAAR9_HUMAN
AccessioniPrimary (citable) accession number: Q96RI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi