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Protein

Trace amine-associated receptor 6

Gene

TAAR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GDB
  • trace-amine receptor activity Source: GO_Central

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GDB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375280. Amine ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 6
Short name:
TaR-6
Short name:
Trace amine receptor 6
Alternative name(s):
Trace amine receptor 4
Short name:
TaR-4
Gene namesi
Name:TAAR6
Synonyms:TA4, TAR4, TRAR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20978. TAAR6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence analysisAdd
BLAST
Transmembranei33 – 5321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini54 – 6815CytoplasmicSequence analysisAdd
BLAST
Transmembranei69 – 8921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini90 – 10718ExtracellularSequence analysisAdd
BLAST
Transmembranei108 – 12821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini129 – 14719CytoplasmicSequence analysisAdd
BLAST
Transmembranei148 – 16821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini169 – 20234ExtracellularSequence analysisAdd
BLAST
Transmembranei203 – 22321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini224 – 25936CytoplasmicSequence analysisAdd
BLAST
Transmembranei260 – 27617Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini277 – 2826ExtracellularSequence analysis
Transmembranei283 – 30220Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini303 – 34543CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: GDB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

MalaCardsiTAAR6.
PharmGKBiPA134881141.

Polymorphism and mutation databases

BioMutaiTAAR6.
DMDMi38258634.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Trace amine-associated receptor 6PRO_0000070158Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Disulfide bondi105 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96RI8.
PRIDEiQ96RI8.

PTM databases

iPTMnetiQ96RI8.
PhosphoSiteiQ96RI8.

Expressioni

Tissue specificityi

Expressed at low abundance in various brain tissues, as well as in fetal liver, but not in the cerebellum or placenta. In the brain, comparable levels of expression in basal ganglia, frontal cortex, substantia nigra, amygdala and hippocampus, highest expression in hippocampus and lowest expression in basal ganglia.1 Publication

Gene expression databases

BgeeiQ96RI8.
CleanExiHS_TAAR6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000275198.

Structurei

3D structure databases

ProteinModelPortaliQ96RI8.
SMRiQ96RI8. Positions 28-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ96RI8.
KOiK05051.
OMAiCIGGCQT.
OrthoDBiEOG7966GS.
PhylomeDBiQ96RI8.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNSSLLVA VQLCYANVNG SCVKIPFSPG SRVILYIVFG FGAVLAVFGN
60 70 80 90 100
LLVMISILHF KQLHSPTNFL VASLACADFL VGVTVMPFSM VRTVESCWYF
110 120 130 140 150
GRSFCTFHTC CDVAFCYSSL FHLCFISIDR YIAVTDPLVY PTKFTVSVSG
160 170 180 190 200
ICISVSWILP LMYSGAVFYT GVYDDGLEEL SDALNCIGGC QTVVNQNWVL
210 220 230 240 250
TDFLSFFIPT FIMIILYGNI FLVARRQAKK IENTGSKTES SSESYKARVA
260 270 280 290 300
RRERKAAKTL GVTVVAFMIS WLPYSIDSLI DAFMGFITPA CIYEICCWCA
310 320 330 340
YYNSAMNPLI YALFYPWFRK AIKVIVTGQV LKNSSATMNL FSEHI
Length:345
Mass (Da):38,451
Last modified:December 1, 2001 - v1
Checksum:i21B1C4968C39FE2C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371I → T.1 Publication
Corresponds to variant rs17061399 [ dbSNP | Ensembl ].
VAR_019794
Natural varianti99 – 991Y → C.
Corresponds to variant rs41298395 [ dbSNP | Ensembl ].
VAR_061227
Natural varianti165 – 1651G → S.1 Publication
Corresponds to variant rs17061401 [ dbSNP | Ensembl ].
VAR_019795
Natural varianti173 – 1731Y → C.1 Publication
Corresponds to variant rs17061404 [ dbSNP | Ensembl ].
VAR_019796
Natural varianti228 – 2281A → V.1 Publication
Corresponds to variant rs17061409 [ dbSNP | Ensembl ].
VAR_019797
Natural varianti265 – 2651V → I.1 Publication
Corresponds to variant rs8192624 [ dbSNP | Ensembl ].
VAR_019798
Natural varianti291 – 2911C → Y.1 Publication
Corresponds to variant rs8192625 [ dbSNP | Ensembl ].
VAR_019799
Natural varianti326 – 3261V → I.1 Publication
Corresponds to variant rs17061419 [ dbSNP | Ensembl ].
VAR_019800

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380192 Genomic DNA. Translation: AAK71243.1.
AY183470 mRNA. Translation: AAO24661.1.
AL513524 Genomic DNA. Translation: CAH72099.1.
BC069157 mRNA. Translation: AAH69157.1.
CCDSiCCDS5155.1.
RefSeqiNP_778237.1. NM_175067.1.
UniGeneiHs.434196.

Genome annotation databases

EnsembliENST00000275198; ENSP00000275198; ENSG00000146383.
GeneIDi319100.
KEGGihsa:319100.
UCSCiuc011eck.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380192 Genomic DNA. Translation: AAK71243.1.
AY183470 mRNA. Translation: AAO24661.1.
AL513524 Genomic DNA. Translation: CAH72099.1.
BC069157 mRNA. Translation: AAH69157.1.
CCDSiCCDS5155.1.
RefSeqiNP_778237.1. NM_175067.1.
UniGeneiHs.434196.

3D structure databases

ProteinModelPortaliQ96RI8.
SMRiQ96RI8. Positions 28-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000275198.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96RI8.
PhosphoSiteiQ96RI8.

Polymorphism and mutation databases

BioMutaiTAAR6.
DMDMi38258634.

Proteomic databases

PaxDbiQ96RI8.
PRIDEiQ96RI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275198; ENSP00000275198; ENSG00000146383.
GeneIDi319100.
KEGGihsa:319100.
UCSCiuc011eck.2. human.

Organism-specific databases

CTDi319100.
GeneCardsiTAAR6.
HGNCiHGNC:20978. TAAR6.
MalaCardsiTAAR6.
MIMi608923. gene.
neXtProtiNX_Q96RI8.
PharmGKBiPA134881141.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ96RI8.
KOiK05051.
OMAiCIGGCQT.
OrthoDBiEOG7966GS.
PhylomeDBiQ96RI8.
TreeFamiTF343107.

Enzyme and pathway databases

ReactomeiR-HSA-375280. Amine ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiTAAR6.
GenomeRNAii319100.
PROiQ96RI8.
SOURCEiSearch...

Gene expression databases

BgeeiQ96RI8.
CleanExiHS_TAAR6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia."
    Duan J., Martinez M., Sanders A.R., Hou C., Saitou N., Kitano T., Mowry B.J., Crowe R.R., Silverman J.M., Levinson D.F., Gejman P.V.
    Am. J. Hum. Genet. 75:624-638(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS THR-37; SER-165; CYS-173; VAL-228; ILE-265; TYR-291 AND ILE-326, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTAAR6_HUMAN
AccessioniPrimary (citable) accession number: Q96RI8
Secondary accession number(s): Q5VUQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.