Q96RI8 (TAAR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trace amine-associated receptor 6
Short name=TaR-6
Short name=Trace amine receptor 6

Alternative name(s):
Trace amine receptor 4
Short name=TaR-4

Gene names

Name:	TAAR6
Synonyms:	TA4, TAR4, TRAR4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed at low abundance in various brain tissues, as well as in fetal liver, but not in the cerebellum or placenta. In the brain, comparable levels of expression in basal ganglia, frontal cortex, substantia nigra, amygdala and hippocampus, highest expression in hippocampus and lowest expression in basal ganglia. Ref.5
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred by curator. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor activity Traceable author statement. Source: GDB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Trace amine-associated receptor 6		PRO_0000070158
Regions
	Topological domain	1 – 32	32	Extracellular Potential
	Transmembrane	33 – 53	21	Helical; Name=1; Potential
	Topological domain	54 – 68	15	Cytoplasmic Potential
	Transmembrane	69 – 89	21	Helical; Name=2; Potential
	Topological domain	90 – 107	18	Extracellular Potential
	Transmembrane	108 – 128	21	Helical; Name=3; Potential
	Topological domain	129 – 147	19	Cytoplasmic Potential
	Transmembrane	148 – 168	21	Helical; Name=4; Potential
	Topological domain	169 – 202	34	Extracellular Potential
	Transmembrane	203 – 223	21	Helical; Name=5; Potential
	Topological domain	224 – 259	36	Cytoplasmic Potential
	Transmembrane	260 – 276	17	Helical; Name=6; Potential
	Topological domain	277 – 282	6	Extracellular Potential
	Transmembrane	283 – 302	20	Helical; Name=7; Potential
	Topological domain	303 – 345	43	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	19	1	N-linked (GlcNAc...) Potential
	Disulfide bond	105 ↔ 190		By similarity
Natural variations
	Natural variant	37	1	I → T. Ref.5 Corresponds to variant rs17061399 [ dbSNP | Ensembl ].		VAR_019794
	Natural variant	99	1	Y → C. Corresponds to variant rs41298395 [ dbSNP | Ensembl ].		VAR_061227
	Natural variant	165	1	G → S. Ref.5 Corresponds to variant rs17061401 [ dbSNP | Ensembl ].		VAR_019795
	Natural variant	173	1	Y → C. Ref.5 Corresponds to variant rs17061404 [ dbSNP | Ensembl ].		VAR_019796
	Natural variant	228	1	A → V. Ref.5 Corresponds to variant rs17061409 [ dbSNP | Ensembl ].		VAR_019797
	Natural variant	265	1	V → I. Ref.5 Corresponds to variant rs8192624 [ dbSNP | Ensembl ].		VAR_019798
	Natural variant	291	1	C → Y. Ref.5 Corresponds to variant rs8192625 [ dbSNP | Ensembl ].		VAR_019799
	Natural variant	326	1	V → I. Ref.5 Corresponds to variant rs17061419 [ dbSNP | Ensembl ].		VAR_019800

Sequences

	Sequence		Length	Mass (Da)
	Q96RI8 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 21B1C4968C39FE2C	FASTA	345	38,451
	10 20 30 40 50 60 MSSNSSLLVA VQLCYANVNG SCVKIPFSPG SRVILYIVFG FGAVLAVFGN LLVMISILHF 70 80 90 100 110 120 KQLHSPTNFL VASLACADFL VGVTVMPFSM VRTVESCWYF GRSFCTFHTC CDVAFCYSSL 130 140 150 160 170 180 FHLCFISIDR YIAVTDPLVY PTKFTVSVSG ICISVSWILP LMYSGAVFYT GVYDDGLEEL 190 200 210 220 230 240 SDALNCIGGC QTVVNQNWVL TDFLSFFIPT FIMIILYGNI FLVARRQAKK IENTGSKTES 250 260 270 280 290 300 SSESYKARVA RRERKAAKTL GVTVVAFMIS WLPYSIDSLI DAFMGFITPA CIYEICCWCA 310 320 330 340 YYNSAMNPLI YALFYPWFRK AIKVIVTGQV LKNSSATMNL FSEHI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Trace amines: identification of a family of mammalian G protein-coupled receptors." Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R., Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S., Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A., Gerald C. Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001) [PubMed: 11459929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia." Duan J., Martinez M., Sanders A.R., Hou C., Saitou N., Kitano T., Mowry B.J., Crowe R.R., Silverman J.M., Levinson D.F., Gejman P.V. Am. J. Hum. Genet. 75:624-638(2004) [PubMed: 15329799] [Abstract] Cited for: VARIANTS THR-37; SER-165; CYS-173; VAL-228; ILE-265; TYR-291 AND ILE-326, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF380192 Genomic DNA. Translation: AAK71243.1. AY183470 mRNA. Translation: AAO24661.1. AL513524 Genomic DNA. Translation: CAH72099.1. BC069157 mRNA. Translation: AAH69157.1.
IPI	IPI00045309.
RefSeq	NP_778237.1. NM_175067.1.
UniGene	Hs.434196.
3D structure databases
ProteinModelPortal	Q96RI8.
SMR	Q96RI8. Positions 31-327.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96RI8.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q96RI8.
Polymorphism databases
DMDM	38258634.
Proteomic databases
PRIDE	Q96RI8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000275198; ENSP00000275198; ENSG00000146383.
GeneID	319100.
KEGG	hsa:319100.
UCSC	uc003qdj.1. human.
Organism-specific databases
CTD	319100.
GeneCards	GC06P132934.
H-InvDB	HIX0200914.
HGNC	HGNC:20978. TAAR6.
MIM	608923. gene.
neXtProt	NX_Q96RI8.
PharmGKB	PA134881141.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17811.
GeneTree	ENSGT00550000074214.
HOGENOM	HBG445348.
HOVERGEN	HBG106962.
InParanoid	Q96RI8.
OMA	GRSFCTF.
OrthoDB	EOG41JZCJ.
PhylomeDB	Q96RI8.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q96RI8.
Bgee	Q96RI8.
CleanEx	HS_TAAR6.
Genevestigator	Q96RI8.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR009132. Trace_amine_rcpt. [Graphical view]
KO	K05051.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01830. TRACEAMINER.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	96471.
SOURCE	Search...

Entry information

Entry name

TAAR6_HUMAN

Accession

Primary (citable) accession number: Q96RI8
Secondary accession number(s): Q5VUQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.