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Protein

Trace amine-associated receptor 6

Gene

TAAR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GDB
  • trace-amine receptor activity Source: GO_Central

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GDB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146383-MONOMER.
ReactomeiR-HSA-375280. Amine ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 6
Short name:
TaR-6
Short name:
Trace amine receptor 6
Alternative name(s):
Trace amine receptor 4
Short name:
TaR-4
Gene namesi
Name:TAAR6
Synonyms:TA4, TAR4, TRAR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20978. TAAR6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 53Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini54 – 68CytoplasmicSequence analysisAdd BLAST15
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 107ExtracellularSequence analysisAdd BLAST18
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini129 – 147CytoplasmicSequence analysisAdd BLAST19
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini169 – 202ExtracellularSequence analysisAdd BLAST34
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 259CytoplasmicSequence analysisAdd BLAST36
Transmembranei260 – 276Helical; Name=6Sequence analysisAdd BLAST17
Topological domaini277 – 282ExtracellularSequence analysis6
Transmembranei283 – 302Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini303 – 345CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

  • integral component of membrane Source: GDB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi319100.
MalaCardsiTAAR6.
OpenTargetsiENSG00000146383.
PharmGKBiPA134881141.

Polymorphism and mutation databases

BioMutaiTAAR6.
DMDMi38258634.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701581 – 345Trace amine-associated receptor 6Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi105 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96RI8.
PRIDEiQ96RI8.

PTM databases

iPTMnetiQ96RI8.
PhosphoSitePlusiQ96RI8.

Expressioni

Tissue specificityi

Expressed at low abundance in various brain tissues, as well as in fetal liver, but not in the cerebellum or placenta. In the brain, comparable levels of expression in basal ganglia, frontal cortex, substantia nigra, amygdala and hippocampus, highest expression in hippocampus and lowest expression in basal ganglia.1 Publication

Gene expression databases

BgeeiENSG00000146383.
CleanExiHS_TAAR6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000275198.

Structurei

3D structure databases

ProteinModelPortaliQ96RI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ96RI8.
KOiK05051.
OMAiICVWCAY.
OrthoDBiEOG091G0BXO.
PhylomeDBiQ96RI8.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNSSLLVA VQLCYANVNG SCVKIPFSPG SRVILYIVFG FGAVLAVFGN
60 70 80 90 100
LLVMISILHF KQLHSPTNFL VASLACADFL VGVTVMPFSM VRTVESCWYF
110 120 130 140 150
GRSFCTFHTC CDVAFCYSSL FHLCFISIDR YIAVTDPLVY PTKFTVSVSG
160 170 180 190 200
ICISVSWILP LMYSGAVFYT GVYDDGLEEL SDALNCIGGC QTVVNQNWVL
210 220 230 240 250
TDFLSFFIPT FIMIILYGNI FLVARRQAKK IENTGSKTES SSESYKARVA
260 270 280 290 300
RRERKAAKTL GVTVVAFMIS WLPYSIDSLI DAFMGFITPA CIYEICCWCA
310 320 330 340
YYNSAMNPLI YALFYPWFRK AIKVIVTGQV LKNSSATMNL FSEHI
Length:345
Mass (Da):38,451
Last modified:December 1, 2001 - v1
Checksum:i21B1C4968C39FE2C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01979437I → T.1 PublicationCorresponds to variant rs17061399dbSNPEnsembl.1
Natural variantiVAR_06122799Y → C.Corresponds to variant rs41298395dbSNPEnsembl.1
Natural variantiVAR_019795165G → S.1 PublicationCorresponds to variant rs17061401dbSNPEnsembl.1
Natural variantiVAR_019796173Y → C.1 PublicationCorresponds to variant rs17061404dbSNPEnsembl.1
Natural variantiVAR_019797228A → V.1 PublicationCorresponds to variant rs17061409dbSNPEnsembl.1
Natural variantiVAR_019798265V → I.1 PublicationCorresponds to variant rs8192624dbSNPEnsembl.1
Natural variantiVAR_019799291C → Y.1 PublicationCorresponds to variant rs8192625dbSNPEnsembl.1
Natural variantiVAR_019800326V → I.1 PublicationCorresponds to variant rs17061419dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380192 Genomic DNA. Translation: AAK71243.1.
AY183470 mRNA. Translation: AAO24661.1.
AL513524 Genomic DNA. Translation: CAH72099.1.
BC069157 mRNA. Translation: AAH69157.1.
CCDSiCCDS5155.1.
RefSeqiNP_778237.1. NM_175067.1.
UniGeneiHs.434196.

Genome annotation databases

EnsembliENST00000275198; ENSP00000275198; ENSG00000146383.
GeneIDi319100.
KEGGihsa:319100.
UCSCiuc011eck.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380192 Genomic DNA. Translation: AAK71243.1.
AY183470 mRNA. Translation: AAO24661.1.
AL513524 Genomic DNA. Translation: CAH72099.1.
BC069157 mRNA. Translation: AAH69157.1.
CCDSiCCDS5155.1.
RefSeqiNP_778237.1. NM_175067.1.
UniGeneiHs.434196.

3D structure databases

ProteinModelPortaliQ96RI8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000275198.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96RI8.
PhosphoSitePlusiQ96RI8.

Polymorphism and mutation databases

BioMutaiTAAR6.
DMDMi38258634.

Proteomic databases

PaxDbiQ96RI8.
PRIDEiQ96RI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275198; ENSP00000275198; ENSG00000146383.
GeneIDi319100.
KEGGihsa:319100.
UCSCiuc011eck.2. human.

Organism-specific databases

CTDi319100.
DisGeNETi319100.
GeneCardsiTAAR6.
HGNCiHGNC:20978. TAAR6.
MalaCardsiTAAR6.
MIMi608923. gene.
neXtProtiNX_Q96RI8.
OpenTargetsiENSG00000146383.
PharmGKBiPA134881141.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ96RI8.
KOiK05051.
OMAiICVWCAY.
OrthoDBiEOG091G0BXO.
PhylomeDBiQ96RI8.
TreeFamiTF343107.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146383-MONOMER.
ReactomeiR-HSA-375280. Amine ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiTAAR6.
GenomeRNAii319100.
PROiQ96RI8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146383.
CleanExiHS_TAAR6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAAR6_HUMAN
AccessioniPrimary (citable) accession number: Q96RI8
Secondary accession number(s): Q5VUQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.