##gff-version 3 Q96RI1 UniProtKB Chain 1 486 . . . ID=PRO_0000053538;Note=Bile acid receptor Q96RI1 UniProtKB Domain 262 486 . . . Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189 Q96RI1 UniProtKB DNA binding 134 209 . . . Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407 Q96RI1 UniProtKB Zinc finger 137 157 . . . Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407 Q96RI1 UniProtKB Zinc finger 173 197 . . . Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407 Q96RI1 UniProtKB Binding site 345 345 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6HL1 Q96RI1 UniProtKB Binding site 375 375 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6HL1 Q96RI1 UniProtKB Binding site 383 383 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6HL1 Q96RI1 UniProtKB Binding site 461 461 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:6HL1 Q96RI1 UniProtKB Modified residue 145 145 . . . Note=Phosphoserine%3B by PKC/PRKCA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18755856;Dbxref=PMID:18755856 Q96RI1 UniProtKB Modified residue 164 164 . . . Note=Phosphoserine%3B by PKC/PRKCA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18755856;Dbxref=PMID:18755856 Q96RI1 UniProtKB Modified residue 167 167 . . . Note=N6-acetyllysine%3B by EP300 Q96RI1 UniProtKB Modified residue 220 220 . . . Note=N6-methyllysine%3B by SETD7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22345554;Dbxref=PMID:22345554 Q96RI1 UniProtKB Modified residue 227 227 . . . Note=N6-acetyllysine%3B by EP300 Q96RI1 UniProtKB Modified residue 456 456 . . . Note=Phosphothreonine%3B by PKC/PRKCZ;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:18668687;Dbxref=PMID:18668687 Q96RI1 UniProtKB Cross-link 132 132 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23546875;Dbxref=PMID:23546875 Q96RI1 UniProtKB Cross-link 289 289 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23546875;Dbxref=PMID:23546875 Q96RI1 UniProtKB Alternative sequence 1 36 . . . ID=VSP_010135;Note=In isoform 3%2C isoform 4 and isoform 5. MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAK->MGSKMNLIEHSHLPTTDEFSFSENLF;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1,ECO:0000303|Ref.2;Dbxref=PMID:15489334 Q96RI1 UniProtKB Alternative sequence 159 209 . . . ID=VSP_044547;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q96RI1 UniProtKB Alternative sequence 207 210 . . . ID=VSP_003665;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12062799,ECO:0000303|Ref.2;Dbxref=PMID:12062799 Q96RI1 UniProtKB Natural variant 149 149 . . . ID=VAR_077017;Note=In PFIC5%3B loss of isoform 4 transcription regulatory region sequence-specific DNA binding activity%3B loss of isoform 4 function in regulation of transcription DNA-templated. Y->YK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26888176;Dbxref=PMID:26888176 Q96RI1 UniProtKB Mutagenesis 132 132 . . . Note=Abrogates SUMO1-mediated inhibition of ligand-induced transcactivation at ABCB11/BSEP and NR0B2/SHP promoters%3B when associated with R-289 and A-291. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23546875;Dbxref=PMID:23546875 Q96RI1 UniProtKB Mutagenesis 132 132 . . . Note=Decreases transcriptional activation SLC51A/OSTA%2C SLC51B/OSTB and ABCB11/BSEP%2C no effect on interaction with RXRA and SETD7. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23462506;Dbxref=PMID:23462506 Q96RI1 UniProtKB Mutagenesis 145 145 . . . Note=Impairs ligand-dependent transactivation activity%2C impairs interaction with PPARGC1A%3B when associated with A-164. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18755856;Dbxref=PMID:18755856 Q96RI1 UniProtKB Mutagenesis 164 164 . . . Note=Impairs ligand-dependent transactivation activity%2C impairs interaction with PPARGC1A%3B when associated with A-145. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18755856;Dbxref=PMID:18755856 Q96RI1 UniProtKB Mutagenesis 167 167 . . . Note=Decreases transcriptional activation of SLC51B/OSTB%2C no effect on SLC51A/OSTA and ABCB11/BSEP%2C no effect on interaction with RXRA and SETD7. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23462506;Dbxref=PMID:23462506 Q96RI1 UniProtKB Mutagenesis 220 220 . . . Note=Decreases transcriptional activation of SLC51B/OSTB%2C no effect on SLC51A/OSTA and ABCB11/BSEP%2C impairs interaction with RXRA and SETD7. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23462506;Dbxref=PMID:23462506 Q96RI1 UniProtKB Mutagenesis 227 227 . . . Note=Decreases transcriptional activation SC51A/OSTA%2C SLC51B/OSTB and ABCB11/BSEP%2C impairs interaction with RXRA and enhances interaction with SETD7%2C decreases association with ABCB11/BSEP promoter. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23462506;Dbxref=PMID:23462506 Q96RI1 UniProtKB Mutagenesis 289 289 . . . Note=Abrogates SUMO1-mediated inhibition of ligand-induced transcactivation at ABCB11/BSEP and NR0B2/SHP promoters%3B when associated with R-132 and A-291. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23546875;Dbxref=PMID:23546875 Q96RI1 UniProtKB Mutagenesis 291 291 . . . Note=Abrogates SUMO1-mediated inhibition of ligand-induced transcactivation at ABCB11/BSEP and NR0B2/SHP promoters%3B when associated with R-132 and R-289. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23546875;Dbxref=PMID:23546875 Q96RI1 UniProtKB Mutagenesis 353 353 . . . Note=Decreases transcriptional activation SLC51A/OSTA%2C SLC51B/OSTB and ABCB11/BSEP%2C no effect on interaction with RXRA and SETD7%2C decreases association with ABCB11/BSEP promoter. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23462506;Dbxref=PMID:23462506 Q96RI1 UniProtKB Mutagenesis 455 455 . . . Note=As a heterodimer with RXRA%2C impaired transcriptional activity. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30275017;Dbxref=PMID:30275017 Q96RI1 UniProtKB Mutagenesis 456 456 . . . Note=Impairs transcriptional activation of ABCB11/BSEP. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18668687;Dbxref=PMID:18668687 Q96RI1 UniProtKB Mutagenesis 474 474 . . . Note=Decreases transcriptional activation SLC51A/OSTA%2C SLC51B/OSTB and ABCB11/BSEP%2C no effect on interaction with RXRA and impairs interaction with SETD7. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23462506;Dbxref=PMID:23462506 Q96RI1 UniProtKB Sequence conflict 198 198 . . . Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96RI1 UniProtKB Sequence conflict 217 217 . . . Note=C->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96RI1 UniProtKB Helix 261 274 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HL1 Q96RI1 UniProtKB Helix 281 289 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HL1 Q96RI1 UniProtKB Helix 294 317 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HL1 Q96RI1 UniProtKB Helix 322 324 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HL1 Q96RI1 UniProtKB Helix 327 349 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HL1 Q96RI1 UniProtKB Beta strand 350 353 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YXD Q96RI1 UniProtKB Turn 354 356 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OIV Q96RI1 UniProtKB Beta strand 357 359 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Y49 Q96RI1 UniProtKB Helix 360 367 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HL1 Q96RI1 UniProtKB Beta strand 369 371 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Q0I Q96RI1 UniProtKB Helix 373 387 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HL1 Q96RI1 UniProtKB Turn 388 390 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OIV Q96RI1 UniProtKB Helix 393 404 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HL1 Q96RI1 UniProtKB Beta strand 409 411 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Q0I Q96RI1 UniProtKB Helix 415 436 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HL1 Q96RI1 UniProtKB Beta strand 438 440 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6A5X Q96RI1 UniProtKB Helix 443 465 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HL1 Q96RI1 UniProtKB Helix 470 472 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HL0 Q96RI1 UniProtKB Helix 477 483 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HL1