Reviewed, UniProtKB/Swiss-Prot Q96RF0 (SNX18_HUMAN)

Names and origin

Protein names

Recommended name:
    Sorting nexin-18
Alternative name(s):
    Sorting nexin-associated Golgi protein 1
    SH3 and PX domain-containing protein 3B

Gene names

Name:	SNX18
Synonyms:	SH3PXD3B, SNAG1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	628 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in several stages of intracellular trafficking By similarity.
Subcellular location	Endomembrane system; Peripheral membrane protein; Cytoplasmic side Potential.
Sequence similarities	Belongs to the sorting nexin family. Contains 1 PX (phox homology) domain. Contains 1 SH3 domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	SH3 domain
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell communication Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphoinositide binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SOS1	Q07889	1	EBI-298169,EBI-297487
SOS2	Q07890	1	EBI-298169,EBI-298181

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96RF0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96RF0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     542-628: KAWPLEQVIW...RVPLMTVLSF → ALTKVKESRR...EEALHKYDSV

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 628	628	Sorting nexin-18		PRO_0000213866
Regions
	Domain	1 – 61	61	SH3
	Domain	276 – 386	111	PX
Natural variations
	Alternative sequence	542 – 628	87	KAWPL…TVLSF → ALTKVKESRRHVEEGKMEVQ KADGIQDRCNTISFATLAEI HHFHQIRVRDFKSQMQHFLQ QQIIFFQKVTQKLEEALHKY DSV in isoform 2.		VSP_035839
	Natural variant	571	1	E → D: dbSNP rs2548612. Ref.1		VAR_052480
	Natural variant	593	1	K → T: dbSNP rs13162502. Ref.3		VAR_052481

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: BE7B16835BA80F9C	FASTA	628	68,894
	10 20 30 40 50 60 MALRARALYD FRSENPGEIS LREHEVLSLC SEQDIEGWLE GVNSRGDRGL FPASYVQVIR 70 80 90 100 110 120 APEPGPAGDG GPGAPARYAN VPPGGFEPLP VAPPASFKPP PDAFQALLQP QQAPPPSTFQ 130 140 150 160 170 180 PPGAGFPYGG GALQPSPQQL YGGYQASQGS DDDWDDEWDD SSTVADEPGA LGSGAYPDLD 190 200 210 220 230 240 GSSSAGVGAA GRYRLSTRSD LSLGSRGGSV PPQHHPSGPK SSATVSRNLN RFSTFVKSGG 250 260 270 280 290 300 EAFVLGEASG FVKDGDKLCV VLGPYGPEWQ ENPYPFQCTI DDPTKQTKFK GMKSYISYKL 310 320 330 340 350 360 VPTHTQVPVH RRYKHFDWLY ARLAEKFPVI SVPHLPEKQA TGRFEEDFIS KRRKGLIWWM 370 380 390 400 410 420 NHMASHPVLA QCDVFQHFLT CPSSTDEKAW KQGKRKAEKD EMVGANFFLT LSTPPAAALD 430 440 450 460 470 480 LQEVESKIDG FKCFTKKMDD SALQLNHTAN EFARKQVTGF KKEYQKVGQS FRGLSQAFEL 490 500 510 520 530 540 DQQAFSVGLN QAIAFTGDAY DAIGELFAEQ PRQDLDPVMD LLALYQGHLA NFPDIIHVQK 550 560 570 580 590 600 GKAWPLEQVI WSVLCRLKGA TLTAVPLWVS ESYSTGEEAS RDVDAWVFSL ECKLDCSTGS 610 620 FLLEYLALGN EYSFSKVQRV PLMTVLSF
	Isoform 2. Checksum: A348EFB754F465E9	FASTA	624	69,006
	10 20 30 40 50 60 MALRARALYD FRSENPGEIS LREHEVLSLC SEQDIEGWLE GVNSRGDRGL FPASYVQVIR 70 80 90 100 110 120 APEPGPAGDG GPGAPARYAN VPPGGFEPLP VAPPASFKPP PDAFQALLQP QQAPPPSTFQ 130 140 150 160 170 180 PPGAGFPYGG GALQPSPQQL YGGYQASQGS DDDWDDEWDD SSTVADEPGA LGSGAYPDLD 190 200 210 220 230 240 GSSSAGVGAA GRYRLSTRSD LSLGSRGGSV PPQHHPSGPK SSATVSRNLN RFSTFVKSGG 250 260 270 280 290 300 EAFVLGEASG FVKDGDKLCV VLGPYGPEWQ ENPYPFQCTI DDPTKQTKFK GMKSYISYKL 310 320 330 340 350 360 VPTHTQVPVH RRYKHFDWLY ARLAEKFPVI SVPHLPEKQA TGRFEEDFIS KRRKGLIWWM 370 380 390 400 410 420 NHMASHPVLA QCDVFQHFLT CPSSTDEKAW KQGKRKAEKD EMVGANFFLT LSTPPAAALD 430 440 450 460 470 480 LQEVESKIDG FKCFTKKMDD SALQLNHTAN EFARKQVTGF KKEYQKVGQS FRGLSQAFEL 490 500 510 520 530 540 DQQAFSVGLN QAIAFTGDAY DAIGELFAEQ PRQDLDPVMD LLALYQGHLA NFPDIIHVQK 550 560 570 580 590 600 GALTKVKESR RHVEEGKMEV QKADGIQDRC NTISFATLAE IHHFHQIRVR DFKSQMQHFL 610 620 QQQIIFFQKV TQKLEEALHK YDSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel SH3-, Pro-rich-, and PX-domain protein of the sorting nexin family." Hong W. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-571. Tissue: Cerebellum.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-593. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF395536 mRNA. Translation: AAK82415.1. CH471123 Genomic DNA. Translation: EAW54894.1. BC060791 mRNA. Translation: AAH60791.1. BC067860 mRNA. Translation: AAH67860.1. BC117218 mRNA. Translation: AAI17219.1. BC117220 mRNA. Translation: AAI17221.1.
IPI	IPI00045219. IPI00657938.
RefSeq	NP_001096045.1. NP_443102.2.
UniGene	Hs.432755 Hs.606166
3D structure databases
HSSP	HSSP built from PDB template 1PKS based on UniProtKB P27986.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96RF0. 2 interactions.
PTM databases
PhosphoSite	Q96RF0.
Proteomic databases
PRIDE	Q96RF0.
Genome annotation databases
Ensembl	ENSG00000178996. Homo sapiens. [Contig view]
GeneID	112574.
KEGG	hsa:112574.
Organism-specific databases
GeneCards	GC05P053850.
HGNC	HGNC:19245. SNX18.
PharmGKB	PA134861851.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q96RF0.
HOVERGEN	Q96RF0.
OMA	Q96RF0. MEVQKAD.
Gene expression databases
ArrayExpress	Q96RF0.
Bgee	Q96RF0.
CleanEx	HS_SNX18.
GermOnline	ENSG00000178996. Homo sapiens.
Family and domain databases
InterPro	IPR001683. PX. IPR011511. SH3_2. IPR001452. SH3_domain. IPR014536. Snx9. IPR019497. Sorting_nexin_WASP-bd-dom. [Graphical view]
Gene3D	G3DSA:3.30.1520.10. PX. 1 hit.
Pfam	PF10456. BAR_3_WASP_bdg. 1 hit. PF00787. PX. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
PIRSF	PIRSF027744. Snx9. 1 hit.
ProDom	PD000066. SH3. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00312. PX. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
PROSITE	PS50195. PX. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SNX18_HUMAN

Accession

Primary (citable) accession number: Q96RF0
Secondary accession number(s): Q05BB3, Q0VG02

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	November 25, 2008
Last modified:	July 7, 2009
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)