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Q96RF0

- SNX18_HUMAN

UniProt

Q96RF0 - SNX18_HUMAN

Protein

Sorting nexin-18

Gene

SNX18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane.4 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei312 – 3121Phosphatidylinositol 4,5-bisphosphateBy similarity
    Binding sitei314 – 3141Phosphatidylinositol 4,5-bisphosphateBy similarity
    Binding sitei338 – 3381Phosphatidylinositol 4,5-bisphosphateBy similarity
    Binding sitei352 – 3521Phosphatidylinositol 4,5-bisphosphateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol-4,5-bisphosphate binding Source: FlyBase
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cleavage furrow formation Source: UniProtKB
    2. endocytosis Source: UniProtKB
    3. endosomal transport Source: UniProtKB
    4. intracellular protein transport Source: RefGenome
    5. mitotic cytokinesis Source: UniProtKB
    6. mitotic nuclear division Source: UniProtKB-KW
    7. positive regulation of GTPase activity Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Endocytosis, Mitosis, Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-18
    Alternative name(s):
    SH3 and PX domain-containing protein 3B
    Sorting nexin-associated Golgi protein 1
    Gene namesi
    Name:SNX18
    Synonyms:SH3PXD3B, SNAG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:19245. SNX18.

    Subcellular locationi

    Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side
    Note: Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation.

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB
    2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    3. endosome Source: RefGenome
    4. endosome membrane Source: UniProtKB-SubCell
    5. extracellular vesicular exosome Source: UniProt
    6. extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
    7. growth cone Source: Ensembl
    8. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162404304.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 628628Sorting nexin-18PRO_0000213866Add
    BLAST

    Proteomic databases

    MaxQBiQ96RF0.
    PaxDbiQ96RF0.
    PRIDEiQ96RF0.

    PTM databases

    PhosphoSiteiQ96RF0.

    Expressioni

    Gene expression databases

    BgeeiQ96RF0.
    CleanExiHS_SNX18.
    GenevestigatoriQ96RF0.

    Organism-specific databases

    HPAiHPA037800.

    Interactioni

    Subunit structurei

    Heterodimer with SNX9. Interacts with ITCH. Interacts with dynamin, SYNJ1 and WASL. Interacts with the AP-1 complex.3 Publications

    Protein-protein interaction databases

    BioGridi125193. 7 interactions.
    IntActiQ96RF0. 8 interactions.
    STRINGi9606.ENSP00000317332.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96RF0.
    SMRiQ96RF0. Positions 6-59, 260-541.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 6161SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini276 – 386111PXPROSITE-ProRule annotationAdd
    BLAST
    Domaini421 – 628208BARAdd
    BLAST

    Domaini

    The PX domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate.

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 BAR domain.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiCOG5391.
    HOGENOMiHOG000261633.
    HOVERGENiHBG009996.
    InParanoidiQ96RF0.
    KOiK17923.
    OMAiDPIMDLL.
    OrthoDBiEOG7ZKS9P.
    PhylomeDBiQ96RF0.
    TreeFamiTF314082.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR001683. Phox.
    IPR001452. SH3_domain.
    IPR028646. SNX18.
    IPR014536. Snx9_subfam.
    IPR019497. Sorting_nexin_WASP-bd-dom.
    [Graphical view]
    PANTHERiPTHR10555:SF13. PTHR10555:SF13. 1 hit.
    PfamiPF10456. BAR_3_WASP_bdg. 1 hit.
    PF00787. PX. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PIRSFiPIRSF027744. Snx9. 1 hit.
    SMARTiSM00312. PX. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96RF0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALRARALYD FRSENPGEIS LREHEVLSLC SEQDIEGWLE GVNSRGDRGL    50
    FPASYVQVIR APEPGPAGDG GPGAPARYAN VPPGGFEPLP VAPPASFKPP 100
    PDAFQALLQP QQAPPPSTFQ PPGAGFPYGG GALQPSPQQL YGGYQASQGS 150
    DDDWDDEWDD SSTVADEPGA LGSGAYPDLD GSSSAGVGAA GRYRLSTRSD 200
    LSLGSRGGSV PPQHHPSGPK SSATVSRNLN RFSTFVKSGG EAFVLGEASG 250
    FVKDGDKLCV VLGPYGPEWQ ENPYPFQCTI DDPTKQTKFK GMKSYISYKL 300
    VPTHTQVPVH RRYKHFDWLY ARLAEKFPVI SVPHLPEKQA TGRFEEDFIS 350
    KRRKGLIWWM NHMASHPVLA QCDVFQHFLT CPSSTDEKAW KQGKRKAEKD 400
    EMVGANFFLT LSTPPAAALD LQEVESKIDG FKCFTKKMDD SALQLNHTAN 450
    EFARKQVTGF KKEYQKVGQS FRGLSQAFEL DQQAFSVGLN QAIAFTGDAY 500
    DAIGELFAEQ PRQDLDPVMD LLALYQGHLA NFPDIIHVQK GKAWPLEQVI 550
    WSVLCRLKGA TLTAVPLWVS ESYSTGEEAS RDVDAWVFSL ECKLDCSTGS 600
    FLLEYLALGN EYSFSKVQRV PLMTVLSF 628
    Length:628
    Mass (Da):68,894
    Last modified:November 25, 2008 - v2
    Checksum:iBE7B16835BA80F9C
    GO
    Isoform 2 (identifier: Q96RF0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         542-628: KAWPLEQVIW...RVPLMTVLSF → ALTKVKESRR...EEALHKYDSV

    Show »
    Length:624
    Mass (Da):69,006
    Checksum:iA348EFB754F465E9
    GO
    Isoform 3 (identifier: Q96RF0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         592-628: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:591
    Mass (Da):64,752
    Checksum:i43574BCAEBF15EDD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321E → G in BAG65075. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti571 – 5711E → D.2 Publications
    Corresponds to variant rs2548612 [ dbSNP | Ensembl ].
    VAR_052480
    Natural varianti593 – 5931K → T.1 Publication
    Corresponds to variant rs13162502 [ dbSNP | Ensembl ].
    VAR_052481

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei542 – 62887KAWPL…TVLSF → ALTKVKESRRHVEEGKMEVQ KADGIQDRCNTISFATLAEI HHFHQIRVRDFKSQMQHFLQ QQIIFFQKVTQKLEEALHKY DSV in isoform 2. 1 PublicationVSP_035839Add
    BLAST
    Alternative sequencei592 – 62837Missing in isoform 3. 1 PublicationVSP_045476Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF395536 mRNA. Translation: AAK82415.1.
    AK304195 mRNA. Translation: BAG65075.1.
    AC091888 Genomic DNA. No translation available.
    CH471123 Genomic DNA. Translation: EAW54894.1.
    BC060791 mRNA. Translation: AAH60791.1.
    BC067860 mRNA. Translation: AAH67860.1.
    BC117218 mRNA. Translation: AAI17219.1.
    BC117220 mRNA. Translation: AAI17221.1.
    CCDSiCCDS3962.1. [Q96RF0-1]
    CCDS43317.1. [Q96RF0-2]
    CCDS54851.1. [Q96RF0-3]
    RefSeqiNP_001096045.1. NM_001102575.1. [Q96RF0-2]
    NP_001138899.1. NM_001145427.1. [Q96RF0-3]
    NP_443102.2. NM_052870.2. [Q96RF0-1]
    UniGeneiHs.432755.
    Hs.606166.

    Genome annotation databases

    EnsembliENST00000326277; ENSP00000317332; ENSG00000178996. [Q96RF0-1]
    ENST00000343017; ENSP00000342276; ENSG00000178996. [Q96RF0-3]
    ENST00000381410; ENSP00000370817; ENSG00000178996. [Q96RF0-2]
    GeneIDi112574.
    KEGGihsa:112574.
    UCSCiuc003jpi.4. human. [Q96RF0-2]
    uc003jpj.4. human. [Q96RF0-1]

    Polymorphism databases

    DMDMi215273942.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF395536 mRNA. Translation: AAK82415.1 .
    AK304195 mRNA. Translation: BAG65075.1 .
    AC091888 Genomic DNA. No translation available.
    CH471123 Genomic DNA. Translation: EAW54894.1 .
    BC060791 mRNA. Translation: AAH60791.1 .
    BC067860 mRNA. Translation: AAH67860.1 .
    BC117218 mRNA. Translation: AAI17219.1 .
    BC117220 mRNA. Translation: AAI17221.1 .
    CCDSi CCDS3962.1. [Q96RF0-1 ]
    CCDS43317.1. [Q96RF0-2 ]
    CCDS54851.1. [Q96RF0-3 ]
    RefSeqi NP_001096045.1. NM_001102575.1. [Q96RF0-2 ]
    NP_001138899.1. NM_001145427.1. [Q96RF0-3 ]
    NP_443102.2. NM_052870.2. [Q96RF0-1 ]
    UniGenei Hs.432755.
    Hs.606166.

    3D structure databases

    ProteinModelPortali Q96RF0.
    SMRi Q96RF0. Positions 6-59, 260-541.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125193. 7 interactions.
    IntActi Q96RF0. 8 interactions.
    STRINGi 9606.ENSP00000317332.

    PTM databases

    PhosphoSitei Q96RF0.

    Polymorphism databases

    DMDMi 215273942.

    Proteomic databases

    MaxQBi Q96RF0.
    PaxDbi Q96RF0.
    PRIDEi Q96RF0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326277 ; ENSP00000317332 ; ENSG00000178996 . [Q96RF0-1 ]
    ENST00000343017 ; ENSP00000342276 ; ENSG00000178996 . [Q96RF0-3 ]
    ENST00000381410 ; ENSP00000370817 ; ENSG00000178996 . [Q96RF0-2 ]
    GeneIDi 112574.
    KEGGi hsa:112574.
    UCSCi uc003jpi.4. human. [Q96RF0-2 ]
    uc003jpj.4. human. [Q96RF0-1 ]

    Organism-specific databases

    CTDi 112574.
    GeneCardsi GC05P053850.
    H-InvDB HIX0174367.
    HGNCi HGNC:19245. SNX18.
    HPAi HPA037800.
    neXtProti NX_Q96RF0.
    PharmGKBi PA162404304.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5391.
    HOGENOMi HOG000261633.
    HOVERGENi HBG009996.
    InParanoidi Q96RF0.
    KOi K17923.
    OMAi DPIMDLL.
    OrthoDBi EOG7ZKS9P.
    PhylomeDBi Q96RF0.
    TreeFami TF314082.

    Miscellaneous databases

    GeneWikii SNAG1.
    GenomeRNAii 112574.
    NextBioi 78612.
    PROi Q96RF0.

    Gene expression databases

    Bgeei Q96RF0.
    CleanExi HS_SNX18.
    Genevestigatori Q96RF0.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR001683. Phox.
    IPR001452. SH3_domain.
    IPR028646. SNX18.
    IPR014536. Snx9_subfam.
    IPR019497. Sorting_nexin_WASP-bd-dom.
    [Graphical view ]
    PANTHERi PTHR10555:SF13. PTHR10555:SF13. 1 hit.
    Pfami PF10456. BAR_3_WASP_bdg. 1 hit.
    PF00787. PX. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF027744. Snx9. 1 hit.
    SMARTi SM00312. PX. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel SH3-, Pro-rich-, and PX-domain protein of the sorting nexin family."
      Hong W.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-571.
      Tissue: Cerebellum.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ASP-571.
      Tissue: Trachea.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-593.
      Tissue: Placenta.
    6. "SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1-positive endosomal trafficking."
      Haberg K., Lundmark R., Carlsson S.R.
      J. Cell Sci. 121:1495-1505(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH THE AP-1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain."
      Baumann C., Lindholm C.K., Rimoldi D., Levy F.
      FEBS J. 277:2803-2814(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ITCH.
    8. "SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane."
      Park J., Kim Y., Lee S., Park J.J., Park Z.Y., Sun W., Kim H., Chang S.
      J. Cell Sci. 123:1742-1750(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH DYNAMIN; WASL AND SYNJ1, SUBUNIT.
    9. "The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins."
      Wang J.T., Kerr M.C., Karunaratne S., Jeanes A., Yap A.S., Teasdale R.D.
      PLoS ONE 5:E13763-E13763(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    10. "SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis."
      Ma M.P., Chircop M.
      J. Cell Sci. 125:4372-4382(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSNX18_HUMAN
    AccessioniPrimary (citable) accession number: Q96RF0
    Secondary accession number(s): B4E2B3
    , H7BXX3, Q05BB3, Q0VG02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3