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Reviewed, UniProtKB/Swiss-Prot Q96RF0 (SNX18_HUMAN)

Last modified July 7, 2009. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Sorting nexin-18
Alternative name(s):
    Sorting nexin-associated Golgi protein 1
    SH3 and PX domain-containing protein 3B
Gene names
Name: SNX18
Synonyms: SH3PXD3B, SNAG1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May be involved in several stages of intracellular trafficking By similarity.

Subcellular location

Endomembrane system; Peripheral membrane protein; Cytoplasmic side Potential.

Sequence similarities

Belongs to the sorting nexin family.

Contains 1 PX (phox homology) domain.

Contains 1 SH3 domain.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSH3 domain
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell communication

Inferred from electronic annotation. Source: InterPro

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentendomembrane system

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionphosphoinositide binding

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96RF0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96RF0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     542-628: KAWPLEQVIW...RVPLMTVLSF → ALTKVKESRR...EEALHKYDSV

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 628628Sorting nexin-18
PRO_0000213866

Regions

Domain1 – 6161SH3
Domain276 – 386111PX

Natural variations

Alternative sequence542 – 62887KAWPL…TVLSF → ALTKVKESRRHVEEGKMEVQ KADGIQDRCNTISFATLAEI HHFHQIRVRDFKSQMQHFLQ QQIIFFQKVTQKLEEALHKY DSV in isoform 2.
VSP_035839
Natural variant5711E → D: dbSNP rs2548612. Ref.1
VAR_052480
Natural variant5931K → T: dbSNP rs13162502. Ref.3
VAR_052481

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: BE7B16835BA80F9C

FASTA62868,894
        10         20         30         40         50         60 
MALRARALYD FRSENPGEIS LREHEVLSLC SEQDIEGWLE GVNSRGDRGL FPASYVQVIR 

        70         80         90        100        110        120 
APEPGPAGDG GPGAPARYAN VPPGGFEPLP VAPPASFKPP PDAFQALLQP QQAPPPSTFQ 

       130        140        150        160        170        180 
PPGAGFPYGG GALQPSPQQL YGGYQASQGS DDDWDDEWDD SSTVADEPGA LGSGAYPDLD 

       190        200        210        220        230        240 
GSSSAGVGAA GRYRLSTRSD LSLGSRGGSV PPQHHPSGPK SSATVSRNLN RFSTFVKSGG 

       250        260        270        280        290        300 
EAFVLGEASG FVKDGDKLCV VLGPYGPEWQ ENPYPFQCTI DDPTKQTKFK GMKSYISYKL 

       310        320        330        340        350        360 
VPTHTQVPVH RRYKHFDWLY ARLAEKFPVI SVPHLPEKQA TGRFEEDFIS KRRKGLIWWM 

       370        380        390        400        410        420 
NHMASHPVLA QCDVFQHFLT CPSSTDEKAW KQGKRKAEKD EMVGANFFLT LSTPPAAALD 

       430        440        450        460        470        480 
LQEVESKIDG FKCFTKKMDD SALQLNHTAN EFARKQVTGF KKEYQKVGQS FRGLSQAFEL 

       490        500        510        520        530        540 
DQQAFSVGLN QAIAFTGDAY DAIGELFAEQ PRQDLDPVMD LLALYQGHLA NFPDIIHVQK 

       550        560        570        580        590        600 
GKAWPLEQVI WSVLCRLKGA TLTAVPLWVS ESYSTGEEAS RDVDAWVFSL ECKLDCSTGS 

       610        620 
FLLEYLALGN EYSFSKVQRV PLMTVLSF 

« Hide

Isoform 2.

Checksum: A348EFB754F465E9
Show »

FASTA62469,006

References

« Hide 'large scale' references
[1]"A novel SH3-, Pro-rich-, and PX-domain protein of the sorting nexin family."
Hong W.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-571.
Tissue: Cerebellum.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-593.
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF395536 mRNA. Translation: AAK82415.1.
CH471123 Genomic DNA. Translation: EAW54894.1.
BC060791 mRNA. Translation: AAH60791.1.
BC067860 mRNA. Translation: AAH67860.1.
BC117218 mRNA. Translation: AAI17219.1.
BC117220 mRNA. Translation: AAI17221.1.
IPIIPI00045219.
IPI00657938.
RefSeqNP_001096045.1.
NP_443102.2.
UniGeneHs.432755
Hs.606166

3D structure databases

HSSPHSSP built from PDB template 1PKS based on UniProtKB P27986.
ModBaseSearch...

Protein-protein interaction databases

IntActQ96RF0. 2 interactions.

PTM databases

PhosphoSiteQ96RF0.

Proteomic databases

PRIDEQ96RF0.

Genome annotation databases

EnsemblENSG00000178996. Homo sapiens. [Contig view]
GeneID112574.
KEGGhsa:112574.

Organism-specific databases

GeneCardsGC05P053850.
HGNCHGNC:19245. SNX18.
PharmGKBPA134861851.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ96RF0.
HOVERGENQ96RF0.
OMAQ96RF0. MEVQKAD.

Gene expression databases

ArrayExpressQ96RF0.
BgeeQ96RF0.
CleanExHS_SNX18.
GermOnlineENSG00000178996. Homo sapiens.

Family and domain databases

InterProIPR001683. PX.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR014536. Snx9.
IPR019497. Sorting_nexin_WASP-bd-dom.
[Graphical view]
Gene3DG3DSA:3.30.1520.10. PX. 1 hit.
PfamPF10456. BAR_3_WASP_bdg. 1 hit.
PF00787. PX. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PIRSFPIRSF027744. Snx9. 1 hit.
ProDomPD000066. SH3. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00312. PX. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
PROSITEPS50195. PX. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSNX18_HUMAN
AccessionPrimary (citable) accession number: Q96RF0
Secondary accession number(s): Q05BB3, Q0VG02
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 25, 2008
Last modified: July 7, 2009
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents