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Protein

Nucleus accumbens-associated protein 1

Gene

NACC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.2 Publications

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • protein homooligomerization Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160877-MONOMER.
SIGNORiQ96RE7.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleus accumbens-associated protein 1
Short name:
NAC-1
Alternative name(s):
BTB/POZ domain-containing protein 14B
Gene namesi
Name:NACC1
Synonyms:BTBD14B, NAC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20967. NACC1.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Distribution in the cytoplasm is dependent on phosphorylation.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nuclear body Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi112939.
OpenTargetsiENSG00000160877.
PharmGKBiPA164723404.

Polymorphism and mutation databases

BioMutaiNACC1.
DMDMi74732694.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002740411 – 527Nucleus accumbens-associated protein 1Add BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei188PhosphoserineCombined sources1
Modified residuei259Phosphoserine; by PKCBy similarity1
Cross-linki483Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96RE7.
MaxQBiQ96RE7.
PaxDbiQ96RE7.
PeptideAtlasiQ96RE7.
PRIDEiQ96RE7.

PTM databases

iPTMnetiQ96RE7.
PhosphoSitePlusiQ96RE7.

Expressioni

Tissue specificityi

Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.2 Publications

Gene expression databases

BgeeiENSG00000160877.
CleanExiHS_NACC1.
ExpressionAtlasiQ96RE7. baseline and differential.
GenevisibleiQ96RE7. HS.

Organism-specific databases

HPAiHPA021238.
HPA062245.

Interactioni

Subunit structurei

Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1.

Protein-protein interaction databases

BioGridi125217. 32 interactors.
IntActiQ96RE7. 19 interactors.
STRINGi9606.ENSP00000292431.

Structurei

Secondary structure

1527
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Helixi12 – 25Combined sources14
Turni26 – 29Combined sources4
Beta strandi32 – 36Combined sources5
Beta strandi39 – 43Combined sources5
Helixi45 – 51Combined sources7
Helixi53 – 61Combined sources9
Beta strandi65 – 68Combined sources4
Helixi75 – 87Combined sources13
Beta strandi88 – 91Combined sources4
Turni94 – 96Combined sources3
Helixi97 – 106Combined sources10
Helixi110 – 113Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GA1X-ray2.10A/B2-125[»]
4U2NX-ray2.30A/B2-125[»]
ProteinModelPortaliQ96RE7.
SMRiQ96RE7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96RE7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 94BTBPROSITE-ProRule annotationAdd BLAST65
Domaini374 – 471BENPROSITE-ProRule annotationAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi194 – 199Poly-Gly6

Sequence similaritiesi

Contains 1 BEN domain.PROSITE-ProRule annotation
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231834.
HOVERGENiHBG052875.
InParanoidiQ96RE7.
KOiK10486.
OMAiNMGDQFL.
OrthoDBiEOG091G05RI.
PhylomeDBiQ96RE7.
TreeFamiTF331184.

Family and domain databases

InterProiIPR018379. BEN_domain.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF10523. BEN. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM01025. BEN. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS51457. BEN. 1 hit.
PS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTLQMEIP NFGNSILECL NEQRLQGLYC DVSVVVKGHA FKAHRAVLAA
60 70 80 90 100
SSSYFRDLFN NSRSAVVELP AAVQPQSFQQ ILSFCYTGRL SMNVGDQFLL
110 120 130 140 150
MYTAGFLQIQ EIMEKGTEFF LKVSSPSCDS QGLHAEEAPS SEPQSPVAQT
160 170 180 190 200
SGWPACSTPL PLVSRVKTEQ QESDSVQCMP VAKRLWDSGQ KEAGGGGNGS
210 220 230 240 250
RKMAKFSTPD LAANRPHQPP PPQQAPVVAA AQPAVAAGAG QPAGGVAAAG
260 270 280 290 300
GVVSGPSTSE RTSPGTSSAY TSDSPGSYHN EEDEEEDGGE EGMDEQYRQI
310 320 330 340 350
CNMYTMYSMM NVGQTAEKVE ALPEQVAPES RNRIRVRQDL ASLPAELINQ
360 370 380 390 400
IGNRCHPKLY DEGDPSEKLE LVTGTNVYIT RAQLMNCHVS AGTRHKVLLR
410 420 430 440 450
RLLASFFDRN TLANSCGTGI RSSTNDPRRK PLDSRVLHAV KYYCQNFAPN
460 470 480 490 500
FKESEMNAIA ADMCTNARRV VRKSWMPKVK VLKAEDDAYT TFISETGKIE
510 520
PDMMGVEHGF ETASHEGEAG PSAEALQ
Length:527
Mass (Da):57,258
Last modified:December 1, 2001 - v1
Checksum:i00BEA89D2DC3DAD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395817 mRNA. Translation: AAK83885.1.
BC055396 mRNA. Translation: AAH55396.1.
CCDSiCCDS12294.1.
RefSeqiNP_443108.1. NM_052876.3.
XP_005259778.1. XM_005259721.3.
UniGeneiHs.531614.

Genome annotation databases

EnsembliENST00000292431; ENSP00000292431; ENSG00000160877.
GeneIDi112939.
KEGGihsa:112939.
UCSCiuc002mwm.5. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Undiagnosed Disease Network

NACC1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395817 mRNA. Translation: AAK83885.1.
BC055396 mRNA. Translation: AAH55396.1.
CCDSiCCDS12294.1.
RefSeqiNP_443108.1. NM_052876.3.
XP_005259778.1. XM_005259721.3.
UniGeneiHs.531614.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GA1X-ray2.10A/B2-125[»]
4U2NX-ray2.30A/B2-125[»]
ProteinModelPortaliQ96RE7.
SMRiQ96RE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125217. 32 interactors.
IntActiQ96RE7. 19 interactors.
STRINGi9606.ENSP00000292431.

PTM databases

iPTMnetiQ96RE7.
PhosphoSitePlusiQ96RE7.

Polymorphism and mutation databases

BioMutaiNACC1.
DMDMi74732694.

Proteomic databases

EPDiQ96RE7.
MaxQBiQ96RE7.
PaxDbiQ96RE7.
PeptideAtlasiQ96RE7.
PRIDEiQ96RE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292431; ENSP00000292431; ENSG00000160877.
GeneIDi112939.
KEGGihsa:112939.
UCSCiuc002mwm.5. human.

Organism-specific databases

CTDi112939.
DisGeNETi112939.
GeneCardsiNACC1.
HGNCiHGNC:20967. NACC1.
HPAiHPA021238.
HPA062245.
MIMi610672. gene.
neXtProtiNX_Q96RE7.
OpenTargetsiENSG00000160877.
PharmGKBiPA164723404.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231834.
HOVERGENiHBG052875.
InParanoidiQ96RE7.
KOiK10486.
OMAiNMGDQFL.
OrthoDBiEOG091G05RI.
PhylomeDBiQ96RE7.
TreeFamiTF331184.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160877-MONOMER.
SIGNORiQ96RE7.

Miscellaneous databases

ChiTaRSiNACC1. human.
EvolutionaryTraceiQ96RE7.
GeneWikiiBTBD14B.
GenomeRNAii112939.
PROiQ96RE7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160877.
CleanExiHS_NACC1.
ExpressionAtlasiQ96RE7. baseline and differential.
GenevisibleiQ96RE7. HS.

Family and domain databases

InterProiIPR018379. BEN_domain.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF10523. BEN. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM01025. BEN. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS51457. BEN. 1 hit.
PS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNACC1_HUMAN
AccessioniPrimary (citable) accession number: Q96RE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.