ID   FCRL5_HUMAN             Reviewed;         977 AA.
AC   Q96RD9; A0N0M2; B7WNT9; B7WP94; Q495Q2; Q495Q4; Q5VYK9; Q6UY46;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   27-MAR-2024, entry version 184.
DE   RecName: Full=Fc receptor-like protein 5;
DE            Short=FcR-like protein 5;
DE            Short=FcRL5;
DE   AltName: Full=BXMAS1;
DE   AltName: Full=Fc receptor homolog 5;
DE            Short=FcRH5;
DE   AltName: Full=Immune receptor translocation-associated protein 2;
DE   AltName: CD_antigen=CD307e;
DE   Flags: Precursor;
GN   Name=FCRL5; Synonyms=FCRH5, IRTA2; ORFNames=UNQ503/PRO820;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND VARIANTS HIS-267;
RP   ASP-418 AND ILE-466.
RX   PubMed=11453668; DOI=10.1006/bbrc.2001.5231;
RA   Nakayama Y., Weissman S.M., Bothwell A.L.M.;
RT   "BXMAS1 identifies a cluster of homologous genes differentially expressed
RT   in B cells.";
RL   Biochem. Biophys. Res. Commun. 285:830-837(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5), TISSUE SPECIFICITY,
RP   DISEASE, AND VARIANTS HIS-267; ASP-418 AND ILE-466.
RX   PubMed=11290337; DOI=10.1016/s1074-7613(01)00109-1;
RA   Hatzivassiliou G., Miller I., Takizawa J., Palanisamy N., Rao P.H.,
RA   Iida S., Tagawa S., Taniwaki M., Russo J., Neri A., Cattoretti G.,
RA   Clynes R., Mendelsohn C., Chaganti R.S.K., Dalla-Favera R.;
RT   "IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B
RT   cells and involved in chromosome 1q21 abnormalities in B cell malignancy.";
RL   Immunity 14:277-289(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS HIS-267; ILE-269;
RP   ASP-418 AND ILE-466.
RX   PubMed=11493702; DOI=10.1073/pnas.171308498;
RA   Davis R.S., Wang Y.-H., Kubagawa H., Cooper M.D.;
RT   "Identification of a family of Fc receptor homologs with preferential B
RT   cell expression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Lymph node;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS HIS-267; ASP-418 AND
RP   ILE-466.
RA   Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B.,
RA   Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O.,
RA   Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I.,
RA   Nickerson D.A.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS ILE-269;
RP   ASP-418 AND ILE-466.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [9]
RP   TISSUE SPECIFICITY.
RX   PubMed=11929751; DOI=10.1182/blood.v99.8.2662;
RA   Miller I., Hatzivassiliou G., Cattoretti G., Mendelsohn C.,
RA   Dalla-Favera R.;
RT   "IRTAs: a new family of immunoglobulin-like receptors differentially
RT   expressed in B cells.";
RL   Blood 99:2662-2669(2002).
RN   [10]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=16849395; DOI=10.1093/intimm/dxl069;
RA   Polson A.G., Zheng B., Elkins K., Chang W., Du C., Dowd P., Yen L., Tan C.,
RA   Hongo J.-A., Koeppen H., Ebens A.;
RT   "Expression pattern of the human FcRH/IRTA receptors in normal tissue and
RT   in B-chronic lymphocytic leukemia.";
RL   Int. Immunol. 18:1363-1373(2006).
RN   [11]
RP   VARIANT [LARGE SCALE ANALYSIS] CYS-687.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May be involved in B-cell development and differentiation in
CC       peripheral lymphoid organs and may be useful markers of B-cell stages.
CC       May have an immunoregulatory role in marginal zone B-cells. May play a
CC       role in fertilization (By similarity). {ECO:0000250|UniProtKB:Q68SN8,
CC       ECO:0000269|PubMed:11453668}.
CC   -!- INTERACTION:
CC       Q96RD9; Q9Y2J4: AMOTL2; NbExp=3; IntAct=EBI-12091825, EBI-746752;
CC       Q96RD9; Q8TC20-4: CAGE1; NbExp=3; IntAct=EBI-12091825, EBI-11522698;
CC       Q96RD9; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-12091825, EBI-739895;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16849395};
CC       Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC       Name=1; Synonyms=IRTA2c;
CC         IsoId=Q96RD9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96RD9-2; Sequence=VSP_017379, VSP_017380;
CC       Name=3; Synonyms=IRTA2a;
CC         IsoId=Q96RD9-3; Sequence=VSP_017385, VSP_017386;
CC       Name=4; Synonyms=IRTA2b;
CC         IsoId=Q96RD9-4; Sequence=VSP_017383, VSP_017384;
CC       Name=5; Synonyms=IRTA2d;
CC         IsoId=Q96RD9-5; Sequence=VSP_017381, VSP_017382;
CC   -!- TISSUE SPECIFICITY: Expressed in marginal zone B-cells, immunoblasts,
CC       tonsillar germinal center centrocytes and in the intraepithelial and
CC       interfollicular regions of the tonsil. Expressed in many lymphoma cell
CC       lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4
CC       and isoform 5 are detected in lymph node, spleen, bone marrow, and
CC       small intestine with preponderance of isoform 3. Expressed in mature
CC       and memory B-cells and down-regulated in germinal center cells (at
CC       protein level). {ECO:0000269|PubMed:11290337,
CC       ECO:0000269|PubMed:11929751, ECO:0000269|PubMed:16849395}.
CC   -!- DOMAIN: Contains 2 copies of a cytoplasmic motif that is referred to as
CC       the immunoreceptor tyrosine-based inhibitor motif (ITIM).
CC       {ECO:0000250}.
CC   -!- DISEASE: Note=A chromosomal aberration involving FCRL5 has been found
CC       in cell lines with 1q21 abnormalities derived from Burkitt lymphoma.
CC       Duplication dup(1)(q21q32). {ECO:0000269|PubMed:11290337}.
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DR   EMBL; AF369794; AAK50059.2; -; mRNA.
DR   EMBL; AF343662; AAK31325.1; -; mRNA.
DR   EMBL; AF343663; AAK31326.1; -; mRNA.
DR   EMBL; AF343664; AAK31327.1; -; mRNA.
DR   EMBL; AF343665; AAK31328.1; -; mRNA.
DR   EMBL; AF397453; AAK93971.1; -; mRNA.
DR   EMBL; AY358085; AAQ88452.1; -; mRNA.
DR   EMBL; AL834187; CAH56486.1; -; mRNA.
DR   EMBL; EF064730; ABK41913.1; -; Genomic_DNA.
DR   EMBL; AL135929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC101066; AAI01067.1; -; mRNA.
DR   EMBL; BC101067; AAI01068.1; -; mRNA.
DR   EMBL; BC101069; AAI01070.1; -; mRNA.
DR   CCDS; CCDS1165.1; -. [Q96RD9-1]
DR   RefSeq; NP_001182317.1; NM_001195388.1.
DR   RefSeq; NP_112571.2; NM_031281.2. [Q96RD9-1]
DR   AlphaFoldDB; Q96RD9; -.
DR   BioGRID; 123640; 16.
DR   IntAct; Q96RD9; 9.
DR   STRING; 9606.ENSP00000354691; -.
DR   GlyCosmos; Q96RD9; 1 site, No reported glycans.
DR   GlyGen; Q96RD9; 4 sites.
DR   iPTMnet; Q96RD9; -.
DR   PhosphoSitePlus; Q96RD9; -.
DR   BioMuta; FCRL5; -.
DR   DMDM; 296439341; -.
DR   jPOST; Q96RD9; -.
DR   MassIVE; Q96RD9; -.
DR   PaxDb; 9606-ENSP00000354691; -.
DR   PeptideAtlas; Q96RD9; -.
DR   ProteomicsDB; 77948; -. [Q96RD9-1]
DR   ProteomicsDB; 77949; -. [Q96RD9-2]
DR   ProteomicsDB; 77950; -. [Q96RD9-3]
DR   ProteomicsDB; 77951; -. [Q96RD9-4]
DR   ProteomicsDB; 77952; -. [Q96RD9-5]
DR   ABCD; Q96RD9; 76 sequenced antibodies.
DR   Antibodypedia; 47044; 306 antibodies from 31 providers.
DR   DNASU; 83416; -.
DR   Ensembl; ENST00000361835.8; ENSP00000354691.3; ENSG00000143297.19. [Q96RD9-1]
DR   Ensembl; ENST00000368189.3; ENSP00000357172.3; ENSG00000143297.19. [Q96RD9-4]
DR   Ensembl; ENST00000368190.7; ENSP00000357173.3; ENSG00000143297.19. [Q96RD9-3]
DR   GeneID; 83416; -.
DR   KEGG; hsa:83416; -.
DR   MANE-Select; ENST00000361835.8; ENSP00000354691.3; NM_031281.3; NP_112571.2.
DR   UCSC; uc001fqu.3; human. [Q96RD9-1]
DR   AGR; HGNC:18508; -.
DR   CTD; 83416; -.
DR   DisGeNET; 83416; -.
DR   GeneCards; FCRL5; -.
DR   HGNC; HGNC:18508; FCRL5.
DR   HPA; ENSG00000143297; Tissue enriched (lymphoid).
DR   MIM; 605877; gene.
DR   neXtProt; NX_Q96RD9; -.
DR   OpenTargets; ENSG00000143297; -.
DR   PharmGKB; PA142671769; -.
DR   VEuPathDB; HostDB:ENSG00000143297; -.
DR   eggNOG; ENOG502S65W; Eukaryota.
DR   GeneTree; ENSGT01050000244808; -.
DR   HOGENOM; CLU_325948_0_0_1; -.
DR   InParanoid; Q96RD9; -.
DR   OMA; NVPAWIE; -.
DR   OrthoDB; 3026247at2759; -.
DR   PhylomeDB; Q96RD9; -.
DR   TreeFam; TF351107; -.
DR   PathwayCommons; Q96RD9; -.
DR   SignaLink; Q96RD9; -.
DR   BioGRID-ORCS; 83416; 11 hits in 1142 CRISPR screens.
DR   ChiTaRS; FCRL5; human.
DR   GeneWiki; FCRL5; -.
DR   GenomeRNAi; 83416; -.
DR   Pharos; Q96RD9; Tbio.
DR   PRO; PR:Q96RD9; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q96RD9; Protein.
DR   Bgee; ENSG00000143297; Expressed in spleen and 108 other cell types or tissues.
DR   GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043235; C:receptor complex; IDA:MGI.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR   CDD; cd00096; Ig; 4.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   PANTHER; PTHR11481:SF109; FC RECEPTOR-LIKE PROTEIN 1; 1.
DR   PANTHER; PTHR11481; IMMUNOGLOBULIN FC RECEPTOR; 1.
DR   Pfam; PF13895; Ig_2; 6.
DR   SMART; SM00409; IG; 9.
DR   SMART; SM00408; IGc2; 8.
DR   SUPFAM; SSF48726; Immunoglobulin; 9.
DR   PROSITE; PS50835; IG_LIKE; 8.
DR   Genevisible; Q96RD9; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Disulfide bond; Fertilization;
KW   Glycoprotein; Immunoglobulin domain; Membrane; Receptor;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..977
FT                   /note="Fc receptor-like protein 5"
FT                   /id="PRO_0000225622"
FT   TOPO_DOM        16..851
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        852..872
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        873..977
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          23..101
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          188..271
FT                   /note="Ig-like C2-type 2"
FT   DOMAIN          287..374
FT                   /note="Ig-like C2-type 3"
FT   DOMAIN          380..463
FT                   /note="Ig-like C2-type 4"
FT   DOMAIN          473..556
FT                   /note="Ig-like C2-type 5"
FT   DOMAIN          566..651
FT                   /note="Ig-like C2-type 6"
FT   DOMAIN          659..744
FT                   /note="Ig-like C2-type 7"
FT   DOMAIN          752..834
FT                   /note="Ig-like C2-type 8"
FT   REGION          879..898
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           897..902
FT                   /note="ITIM motif 1"
FT   MOTIF           910..915
FT                   /note="ITIM motif 2"
FT   MOTIF           922..927
FT                   /note="ITIM motif 3"
FT   MOTIF           952..957
FT                   /note="ITIM motif 4"
FT   CARBOHYD        383
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        44..85
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        211..260
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        308..355
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        401..448
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        494..541
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        587..634
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        680..727
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        773..819
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   VAR_SEQ         103..124
FT                   /note="ASLILQAPLSVFEGDSVVLRCR -> EMGFPHAAQANVELLGSSDLLT (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12975309,
FT                   ECO:0000303|PubMed:17974005"
FT                   /id="VSP_017379"
FT   VAR_SEQ         125..977
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12975309,
FT                   ECO:0000303|PubMed:17974005"
FT                   /id="VSP_017380"
FT   VAR_SEQ         152
FT                   /note="H -> Q (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:11290337"
FT                   /id="VSP_017381"
FT   VAR_SEQ         153..977
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:11290337"
FT                   /id="VSP_017382"
FT   VAR_SEQ         561..592
FT                   /note="VPVSRPILTLRVPRAQAVVGDLLELHCEAPRG -> GKCWVLASHPPLAEFS
FT                   LTHSFKNLFALSSFLP (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:11290337"
FT                   /id="VSP_017383"
FT   VAR_SEQ         593..977
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:11290337"
FT                   /id="VSP_017384"
FT   VAR_SEQ         747..759
FT                   /note="VPVSRPVLTLRAP -> GEWALPTSSTSEN (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:11290337"
FT                   /id="VSP_017385"
FT   VAR_SEQ         760..977
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:11290337"
FT                   /id="VSP_017386"
FT   VARIANT         267
FT                   /note="Y -> H (in dbSNP:rs6679793)"
FT                   /evidence="ECO:0000269|PubMed:11290337,
FT                   ECO:0000269|PubMed:11453668, ECO:0000269|PubMed:11493702,
FT                   ECO:0000269|Ref.6"
FT                   /id="VAR_025447"
FT   VARIANT         269
FT                   /note="V -> I (in dbSNP:rs12036228)"
FT                   /evidence="ECO:0000269|PubMed:11493702,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_025448"
FT   VARIANT         418
FT                   /note="G -> D (in dbSNP:rs2012199)"
FT                   /evidence="ECO:0000269|PubMed:11290337,
FT                   ECO:0000269|PubMed:11453668, ECO:0000269|PubMed:11493702,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|Ref.6"
FT                   /id="VAR_025449"
FT   VARIANT         427
FT                   /note="N -> K (in dbSNP:rs16838748)"
FT                   /id="VAR_056044"
FT   VARIANT         457
FT                   /note="Q -> R (in dbSNP:rs34868810)"
FT                   /id="VAR_056045"
FT   VARIANT         466
FT                   /note="V -> I (in dbSNP:rs6427384)"
FT                   /evidence="ECO:0000269|PubMed:11290337,
FT                   ECO:0000269|PubMed:11453668, ECO:0000269|PubMed:11493702,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|Ref.6"
FT                   /id="VAR_025450"
FT   VARIANT         687
FT                   /note="S -> C (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_035514"
FT   CONFLICT        733
FT                   /note="L -> P (in Ref. 1; AAK50059)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        890
FT                   /note="S -> P (in Ref. 1; AAK50059)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   977 AA;  106437 MW;  9545DA1B6A164FDD CRC64;
     MLLWVILLVL APVSGQFART PRPIIFLQPP WTTVFQGERV TLTCKGFRFY SPQKTKWYHR
     YLGKEILRET PDNILEVQES GEYRCQAQGS PLSSPVHLDF SSASLILQAP LSVFEGDSVV
     LRCRAKAEVT LNNTIYKNDN VLAFLNKRTD FHIPHACLKD NGAYRCTGYK ESCCPVSSNT
     VKIQVQEPFT RPVLRASSFQ PISGNPVTLT CETQLSLERS DVPLRFRFFR DDQTLGLGWS
     LSPNFQITAM WSKDSGFYWC KAATMPYSVI SDSPRSWIQV QIPASHPVLT LSPEKALNFE
     GTKVTLHCET QEDSLRTLYR FYHEGVPLRH KSVRCERGAS ISFSLTTENS GNYYCTADNG
     LGAKPSKAVS LSVTVPVSHP VLNLSSPEDL IFEGAKVTLH CEAQRGSLPI LYQFHHEGAA
     LERRSANSAG GVAISFSLTA EHSGNYYCTA DNGFGPQRSK AVSLSVTVPV SHPVLTLSSA
     EALTFEGATV TLHCEVQRGS PQILYQFYHE DMPLWSSSTP SVGRVSFSFS LTEGHSGNYY
     CTADNGFGPQ RSEVVSLFVT VPVSRPILTL RVPRAQAVVG DLLELHCEAP RGSPPILYWF
     YHEDVTLGSS SAPSGGEASF NLSLTAEHSG NYSCEANNGL VAQHSDTISL SVIVPVSRPI
     LTFRAPRAQA VVGDLLELHC EALRGSSPIL YWFYHEDVTL GKISAPSGGG ASFNLSLTTE
     HSGIYSCEAD NGLEAQRSEM VTLKVAVPVS RPVLTLRAPG THAAVGDLLE LHCEALRGSP
     LILYRFFHED VTLGNRSSPS GGASLNLSLT AEHSGNYSCE ADNGLGAQRS ETVTLYITGL
     TANRSGPFAT GVAGGLLSIA GLAAGALLLY CWLSRKAGRK PASDPARSPS DSDSQEPTYH
     NVPAWEELQP VYTNANPRGE NVVYSEVRII QEKKKHAVAS DPRHLRNKGS PIIYSEVKVA
     STPVSGSLFL ASSAPHR
//