Q96RD9 (FCRL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fc receptor-like protein 5
Short name=FcR-like protein 5
Short name=FcRL5

Alternative name(s):
BXMAS1
Fc receptor homolog 5
Short name=FcRH5
Immune receptor translocation-associated protein 2
CD_antigen=CD307e

Gene names

Name:	FCRL5
Synonyms:	FCRH5, IRTA2
ORF Names:	UNQ503/PRO820

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	977 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. Ref.1
Subcellular location	Cell membrane; Single-pass type I membrane protein Ref.10.
Tissue specificity	Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level). Ref.2 Ref.9 Ref.10
Domain	Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM) By similarity.
Involvement in disease	A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup1(q21q32). Ref.2
Sequence similarities	Contains 8 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96RD9-1)

Also known as: IRTA2c;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96RD9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     103-124: ASLILQAPLSVFEGDSVVLRCR → EMGFPHAAQANVELLGSSDLLT
     125-977: Missing.

Isoform 3 (identifier: Q96RD9-3)

Also known as: IRTA2a;

The sequence of this isoform differs from the canonical sequence as follows:
     747-759: VPVSRPVLTLRAP → GEWALPTSSTSEN
     760-977: Missing.

Isoform 4 (identifier: Q96RD9-4)

Also known as: IRTA2b;

The sequence of this isoform differs from the canonical sequence as follows:
     561-592: VPVSRPILTLRVPRAQAVVGDLLELHCEAPRG → GKCWVLASHPPLAEFSLTHSFKNLFALSSFLP
     593-977: Missing.

Isoform 5 (identifier: Q96RD9-5)

Also known as: IRTA2d;

The sequence of this isoform differs from the canonical sequence as follows:
     152-152: H → Q
     153-977: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 977	962	Fc receptor-like protein 5		PRO_0000225622
Regions
	Topological domain	16 – 851	836	Extracellular Potential
	Transmembrane	852 – 872	21	Helical; Potential
	Topological domain	873 – 977	105	Cytoplasmic Potential
	Domain	23 – 101	79	Ig-like C2-type 1
	Domain	188 – 271	84	Ig-like C2-type 2
	Domain	287 – 374	88	Ig-like C2-type 3
	Domain	380 – 463	84	Ig-like C2-type 4
	Domain	473 – 556	84	Ig-like C2-type 5
	Domain	566 – 651	86	Ig-like C2-type 6
	Domain	659 – 744	86	Ig-like C2-type 7
	Domain	752 – 834	83	Ig-like C2-type 8
	Motif	897 – 902	6	ITIM motif 1
	Motif	910 – 915	6	ITIM motif 2
	Motif	922 – 927	6	ITIM motif 3
	Motif	952 – 957	6	ITIM motif 4
Amino acid modifications
	Glycosylation	383	1	N-linked (GlcNAc...) Potential
	Disulfide bond	44 ↔ 85		By similarity
	Disulfide bond	211 ↔ 260		By similarity
	Disulfide bond	308 ↔ 355		By similarity
	Disulfide bond	401 ↔ 448		By similarity
	Disulfide bond	494 ↔ 541		By similarity
	Disulfide bond	587 ↔ 634		By similarity
	Disulfide bond	680 ↔ 727		By similarity
	Disulfide bond	773 ↔ 819		By similarity
Natural variations
	Alternative sequence	103 – 124	22	ASLIL…VLRCR → EMGFPHAAQANVELLGSSDL LT in isoform 2.		VSP_017379
	Alternative sequence	125 – 977	853	Missing in isoform 2.		VSP_017380
	Alternative sequence	152	1	H → Q in isoform 5.		VSP_017381
	Alternative sequence	153 – 977	825	Missing in isoform 5.		VSP_017382
	Alternative sequence	561 – 592	32	VPVSR…EAPRG → GKCWVLASHPPLAEFSLTHS FKNLFALSSFLP in isoform 4.		VSP_017383
	Alternative sequence	593 – 977	385	Missing in isoform 4.		VSP_017384
	Alternative sequence	747 – 759	13	VPVSR…TLRAP → GEWALPTSSTSEN in isoform 3.		VSP_017385
	Alternative sequence	760 – 977	218	Missing in isoform 3.		VSP_017386
	Natural variant	267	1	Y → H. Ref.1 Ref.2 Ref.3 Ref.6 Corresponds to variant rs6679793 [ dbSNP | Ensembl ].		VAR_025447
	Natural variant	269	1	V → I. Ref.3 Ref.8 Corresponds to variant rs12036228 [ dbSNP | Ensembl ].		VAR_025448
	Natural variant	418	1	G → D. Ref.1 Ref.2 Ref.3 Ref.6 Ref.8 Corresponds to variant rs2012199 [ dbSNP | Ensembl ].		VAR_025449
	Natural variant	427	1	N → K. Corresponds to variant rs16838748 [ dbSNP | Ensembl ].		VAR_056044
	Natural variant	457	1	Q → R. Corresponds to variant rs34868810 [ dbSNP | Ensembl ].		VAR_056045
	Natural variant	466	1	V → I. Ref.1 Ref.2 Ref.3 Ref.6 Ref.8 Corresponds to variant rs6427384 [ dbSNP | Ensembl ].		VAR_025450
	Natural variant	687	1	S → C in a breast cancer sample; somatic mutation. Ref.11		VAR_035514
Experimental info
	Sequence conflict	733	1	L → P in AAK50059. Ref.1
	Sequence conflict	890	1	S → P in AAK50059. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (IRTA2c) [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 9545DA1B6A164FDD	FASTA	977	106,437
	10 20 30 40 50 60 MLLWVILLVL APVSGQFART PRPIIFLQPP WTTVFQGERV TLTCKGFRFY SPQKTKWYHR 70 80 90 100 110 120 YLGKEILRET PDNILEVQES GEYRCQAQGS PLSSPVHLDF SSASLILQAP LSVFEGDSVV 130 140 150 160 170 180 LRCRAKAEVT LNNTIYKNDN VLAFLNKRTD FHIPHACLKD NGAYRCTGYK ESCCPVSSNT 190 200 210 220 230 240 VKIQVQEPFT RPVLRASSFQ PISGNPVTLT CETQLSLERS DVPLRFRFFR DDQTLGLGWS 250 260 270 280 290 300 LSPNFQITAM WSKDSGFYWC KAATMPYSVI SDSPRSWIQV QIPASHPVLT LSPEKALNFE 310 320 330 340 350 360 GTKVTLHCET QEDSLRTLYR FYHEGVPLRH KSVRCERGAS ISFSLTTENS GNYYCTADNG 370 380 390 400 410 420 LGAKPSKAVS LSVTVPVSHP VLNLSSPEDL IFEGAKVTLH CEAQRGSLPI LYQFHHEGAA 430 440 450 460 470 480 LERRSANSAG GVAISFSLTA EHSGNYYCTA DNGFGPQRSK AVSLSVTVPV SHPVLTLSSA 490 500 510 520 530 540 EALTFEGATV TLHCEVQRGS PQILYQFYHE DMPLWSSSTP SVGRVSFSFS LTEGHSGNYY 550 560 570 580 590 600 CTADNGFGPQ RSEVVSLFVT VPVSRPILTL RVPRAQAVVG DLLELHCEAP RGSPPILYWF 610 620 630 640 650 660 YHEDVTLGSS SAPSGGEASF NLSLTAEHSG NYSCEANNGL VAQHSDTISL SVIVPVSRPI 670 680 690 700 710 720 LTFRAPRAQA VVGDLLELHC EALRGSSPIL YWFYHEDVTL GKISAPSGGG ASFNLSLTTE 730 740 750 760 770 780 HSGIYSCEAD NGLEAQRSEM VTLKVAVPVS RPVLTLRAPG THAAVGDLLE LHCEALRGSP 790 800 810 820 830 840 LILYRFFHED VTLGNRSSPS GGASLNLSLT AEHSGNYSCE ADNGLGAQRS ETVTLYITGL 850 860 870 880 890 900 TANRSGPFAT GVAGGLLSIA GLAAGALLLY CWLSRKAGRK PASDPARSPS DSDSQEPTYH 910 920 930 940 950 960 NVPAWEELQP VYTNANPRGE NVVYSEVRII QEKKKHAVAS DPRHLRNKGS PIIYSEVKVA 970 STPVSGSLFL ASSAPHR
	Isoform 2 [UniParc]. Checksum: D7915849A385455D	FASTA	124	14,080
	10 20 30 40 50 60 MLLWVILLVL APVSGQFART PRPIIFLQPP WTTVFQGERV TLTCKGFRFY SPQKTKWYHR 70 80 90 100 110 120 YLGKEILRET PDNILEVQES GEYRCQAQGS PLSSPVHLDF SSEMGFPHAA QANVELLGSS DLLT
	Isoform 3 (IRTA2a) [UniParc]. Checksum: 11903D6E89081BC9	FASTA	759	83,293
	10 20 30 40 50 60 MLLWVILLVL APVSGQFART PRPIIFLQPP WTTVFQGERV TLTCKGFRFY SPQKTKWYHR 70 80 90 100 110 120 YLGKEILRET PDNILEVQES GEYRCQAQGS PLSSPVHLDF SSASLILQAP LSVFEGDSVV 130 140 150 160 170 180 LRCRAKAEVT LNNTIYKNDN VLAFLNKRTD FHIPHACLKD NGAYRCTGYK ESCCPVSSNT 190 200 210 220 230 240 VKIQVQEPFT RPVLRASSFQ PISGNPVTLT CETQLSLERS DVPLRFRFFR DDQTLGLGWS 250 260 270 280 290 300 LSPNFQITAM WSKDSGFYWC KAATMPYSVI SDSPRSWIQV QIPASHPVLT LSPEKALNFE 310 320 330 340 350 360 GTKVTLHCET QEDSLRTLYR FYHEGVPLRH KSVRCERGAS ISFSLTTENS GNYYCTADNG 370 380 390 400 410 420 LGAKPSKAVS LSVTVPVSHP VLNLSSPEDL IFEGAKVTLH CEAQRGSLPI LYQFHHEGAA 430 440 450 460 470 480 LERRSANSAG GVAISFSLTA EHSGNYYCTA DNGFGPQRSK AVSLSVTVPV SHPVLTLSSA 490 500 510 520 530 540 EALTFEGATV TLHCEVQRGS PQILYQFYHE DMPLWSSSTP SVGRVSFSFS LTEGHSGNYY 550 560 570 580 590 600 CTADNGFGPQ RSEVVSLFVT VPVSRPILTL RVPRAQAVVG DLLELHCEAP RGSPPILYWF 610 620 630 640 650 660 YHEDVTLGSS SAPSGGEASF NLSLTAEHSG NYSCEANNGL VAQHSDTISL SVIVPVSRPI 670 680 690 700 710 720 LTFRAPRAQA VVGDLLELHC EALRGSSPIL YWFYHEDVTL GKISAPSGGG ASFNLSLTTE 730 740 750 HSGIYSCEAD NGLEAQRSEM VTLKVAGEWA LPTSSTSEN
	Isoform 4 (IRTA2b) [UniParc]. Checksum: D99E9511BC528621	FASTA	592	65,617
	10 20 30 40 50 60 MLLWVILLVL APVSGQFART PRPIIFLQPP WTTVFQGERV TLTCKGFRFY SPQKTKWYHR 70 80 90 100 110 120 YLGKEILRET PDNILEVQES GEYRCQAQGS PLSSPVHLDF SSASLILQAP LSVFEGDSVV 130 140 150 160 170 180 LRCRAKAEVT LNNTIYKNDN VLAFLNKRTD FHIPHACLKD NGAYRCTGYK ESCCPVSSNT 190 200 210 220 230 240 VKIQVQEPFT RPVLRASSFQ PISGNPVTLT CETQLSLERS DVPLRFRFFR DDQTLGLGWS 250 260 270 280 290 300 LSPNFQITAM WSKDSGFYWC KAATMPYSVI SDSPRSWIQV QIPASHPVLT LSPEKALNFE 310 320 330 340 350 360 GTKVTLHCET QEDSLRTLYR FYHEGVPLRH KSVRCERGAS ISFSLTTENS GNYYCTADNG 370 380 390 400 410 420 LGAKPSKAVS LSVTVPVSHP VLNLSSPEDL IFEGAKVTLH CEAQRGSLPI LYQFHHEGAA 430 440 450 460 470 480 LERRSANSAG GVAISFSLTA EHSGNYYCTA DNGFGPQRSK AVSLSVTVPV SHPVLTLSSA 490 500 510 520 530 540 EALTFEGATV TLHCEVQRGS PQILYQFYHE DMPLWSSSTP SVGRVSFSFS LTEGHSGNYY 550 560 570 580 590 CTADNGFGPQ RSEVVSLFVT GKCWVLASHP PLAEFSLTHS FKNLFALSSF LP
	Isoform 5 (IRTA2d) [UniParc]. Checksum: 0437E9CBE8D3792C	FASTA	152	17,377
	10 20 30 40 50 60 MLLWVILLVL APVSGQFART PRPIIFLQPP WTTVFQGERV TLTCKGFRFY SPQKTKWYHR 70 80 90 100 110 120 YLGKEILRET PDNILEVQES GEYRCQAQGS PLSSPVHLDF SSASLILQAP LSVFEGDSVV 130 140 150 LRCRAKAEVT LNNTIYKNDN VLAFLNKRTD FQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"BXMAS1 identifies a cluster of homologous genes differentially expressed in B cells." Nakayama Y., Weissman S.M., Bothwell A.L.M. Biochem. Biophys. Res. Commun. 285:830-837(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANTS HIS-267; ASP-418 AND ILE-466.
[2]	"IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy." Hatzivassiliou G., Miller I., Takizawa J., Palanisamy N., Rao P.H., Iida S., Tagawa S., Taniwaki M., Russo J., Neri A., Cattoretti G., Clynes R., Mendelsohn C., Chaganti R.S.K., Dalla-Favera R. Immunity 14:277-289(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5), TISSUE SPECIFICITY, DISEASE, VARIANTS HIS-267; ASP-418 AND ILE-466.
[3]	"Identification of a family of Fc receptor homologs with preferential B cell expression." Davis R.S., Wang Y.-H., Kubagawa H., Cooper M.D. Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS HIS-267; ILE-269; ASP-418 AND ILE-466.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Lymph node.
[6]	Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-267; ASP-418 AND ILE-466.
[7]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ILE-269; ASP-418 AND ILE-466.
[9]	"IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells." Miller I., Hatzivassiliou G., Cattoretti G., Mendelsohn C., Dalla-Favera R. Blood 99:2662-2669(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[10]	"Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia." Polson A.G., Zheng B., Elkins K., Chang W., Du C., Dowd P., Yen L., Tan C., Hongo J.-A., Koeppen H., Ebens A. Int. Immunol. 18:1363-1373(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[11]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-687.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF369794 mRNA. Translation: AAK50059.2. AF343662 mRNA. Translation: AAK31325.1. AF343663 mRNA. Translation: AAK31326.1. AF343664 mRNA. Translation: AAK31327.1. AF343665 mRNA. Translation: AAK31328.1. AF397453 mRNA. Translation: AAK93971.1. AY358085 mRNA. Translation: AAQ88452.1. AL834187 mRNA. Translation: CAH56486.1. EF064730 Genomic DNA. Translation: ABK41913.1. AL353899, AL135929 Genomic DNA. Translation: CAH71427.1. BC101066 mRNA. Translation: AAI01067.1. BC101067 mRNA. Translation: AAI01068.1. BC101069 mRNA. Translation: AAI01070.1.
IPI	IPI00290135. IPI00432728. IPI00644064. IPI00647675. IPI00738292.
RefSeq	NP_001182317.1. NM_001195388.1. NP_112571.2. NM_031281.2.
UniGene	Hs.415950.
3D structure databases
ProteinModelPortal	Q96RD9.
SMR	Q96RD9. Positions 21-838.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000354691.
Protein family/group databases
MEROPS	I43.001.
PTM databases
PhosphoSite	Q96RD9.
Polymorphism databases
DMDM	296439341.
Proteomic databases
PaxDb	Q96RD9.
PRIDE	Q96RD9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361835; ENSP00000354691; ENSG00000143297. ENST00000368188; ENSP00000357171; ENSG00000143297. ENST00000368189; ENSP00000357172; ENSG00000143297. ENST00000368190; ENSP00000357173; ENSG00000143297.
GeneID	83416.
KEGG	hsa:83416.
UCSC	uc001fqu.3. human. uc001fqv.1. human. uc010phv.1. human.
Organism-specific databases
CTD	83416.
GeneCards	GC01M157477.
HGNC	HGNC:18508. FCRL5.
HPA	HPA039998.
MIM	605877. gene.
neXtProt	NX_Q96RD9.
PharmGKB	PA142671769.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG151212.
HOVERGEN	HBG074073.
KO	K06727.
OMA	LPILYQF.
OrthoDB	EOG4V436X.
Gene expression databases
ArrayExpress	Q96RD9.
Bgee	Q96RD9.
CleanEx	HS_FCRL5.
Genevestigator	Q96RD9.
GermOnline	ENSG00000143297. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 9 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. [Graphical view]
SMART	SM00409. IG. 7 hits. SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 8 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	83416.
NextBio	72304.
SOURCE	Search...

Entry information

Entry name

FCRL5_HUMAN

Accession

Primary (citable) accession number: Q96RD9
Secondary accession number(s): A0N0M2 , B7WNT9, B7WP94, Q495Q2, Q495Q4, Q5VYK9, Q6UY46

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 105 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.