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Protein

Olfactory receptor 52E6

Gene

OR52E6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32024-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52E6
Alternative name(s):
Olfactory receptor OR11-58
Gene namesi
Name:OR52E6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15215. OR52E6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 274ExtracellularSequence analysisAdd BLAST15
Transmembranei275 – 295Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini296 – 313CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi390078.
OpenTargetsiENSG00000205409.
PharmGKBiPA32407.

Polymorphism and mutation databases

BioMutaiOR52E6.
DMDMi20532197.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507751 – 313Olfactory receptor 52E6Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96RD3.
PRIDEiQ96RD3.

PTM databases

iPTMnetiQ96RD3.
PhosphoSitePlusiQ96RD3.

Expressioni

Gene expression databases

CleanExiHS_OR52E6.
ExpressionAtlasiQ96RD3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328878.

Structurei

3D structure databases

ProteinModelPortaliQ96RD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCA4. Eukaryota.
ENOG4110P6C. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ96RD3.
KOiK04257.
PhylomeDBiQ96RD3.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIANDTQFH TSSFLLLGIP GLEDVHIWIG FPFFSVYLIA LLGNAAIFFV
60 70 80 90 100
IQTEQSLHEP MYYCLAMLDS IDLSLSTATI PKMLGIFWFN IKEISFGGYL
110 120 130 140 150
SQMFFIHFFT VMESIVLVAM AFDRYIAICK PLWYTMILTS KIISLIAGIA
160 170 180 190 200
VLRSLYMVIP LVFLLLRLPF CGHRIIPHTY CEHMGIARLA CASIKVNIMF
210 220 230 240 250
GLGSISLLLL DVLLIILSHI RILYAVFCLP SWEARLKALN TCGSHIGVIL
260 270 280 290 300
AFSTPAFFSF FTHCFGHDIP QYIHIFLANL YVVVPPTLNP VIYGVRTKHI
310
RETVLRIFFK TDH
Length:313
Mass (Da):35,524
Last modified:May 10, 2002 - v2
Checksum:i6FC174DBDCB20BB3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04806639I → V.Corresponds to variant rs4362173dbSNPEnsembl.1
Natural variantiVAR_04806748F → L.Corresponds to variant rs10769272dbSNPEnsembl.1
Natural variantiVAR_04806864C → F.Corresponds to variant rs4495918dbSNPEnsembl.1
Natural variantiVAR_04806995S → P.Corresponds to variant rs4592451dbSNPEnsembl.1
Natural variantiVAR_048070133W → R.Corresponds to variant rs10838719dbSNPEnsembl.1
Natural variantiVAR_048071159I → V.Corresponds to variant rs4357719dbSNPEnsembl.1
Natural variantiVAR_048072170F → Y.Corresponds to variant rs7943698dbSNPEnsembl.1
Natural variantiVAR_048073199M → R.Corresponds to variant rs10742809dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065815 Genomic DNA. Translation: BAC06034.1.
CH471064 Genomic DNA. Translation: EAW68758.1.
AF399504 Genomic DNA. Translation: AAK94989.1.
BK004304 Genomic DNA. Translation: DAA04702.1.
CCDSiCCDS53597.1.
RefSeqiNP_001005167.1. NM_001005167.1.
UniGeneiHs.534693.

Genome annotation databases

EnsembliENST00000329322; ENSP00000328878; ENSG00000205409.
GeneIDi390078.
KEGGihsa:390078.
UCSCiuc010qzq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065815 Genomic DNA. Translation: BAC06034.1.
CH471064 Genomic DNA. Translation: EAW68758.1.
AF399504 Genomic DNA. Translation: AAK94989.1.
BK004304 Genomic DNA. Translation: DAA04702.1.
CCDSiCCDS53597.1.
RefSeqiNP_001005167.1. NM_001005167.1.
UniGeneiHs.534693.

3D structure databases

ProteinModelPortaliQ96RD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000328878.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96RD3.
PhosphoSitePlusiQ96RD3.

Polymorphism and mutation databases

BioMutaiOR52E6.
DMDMi20532197.

Proteomic databases

PaxDbiQ96RD3.
PRIDEiQ96RD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329322; ENSP00000328878; ENSG00000205409.
GeneIDi390078.
KEGGihsa:390078.
UCSCiuc010qzq.3. human.

Organism-specific databases

CTDi390078.
DisGeNETi390078.
GeneCardsiOR52E6.
HGNCiHGNC:15215. OR52E6.
neXtProtiNX_Q96RD3.
OpenTargetsiENSG00000205409.
PharmGKBiPA32407.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCA4. Eukaryota.
ENOG4110P6C. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ96RD3.
KOiK04257.
PhylomeDBiQ96RD3.
TreeFamiTF343679.

Enzyme and pathway databases

BioCyciZFISH:G66-32024-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52E6.
GenomeRNAii390078.
PROiQ96RD3.

Gene expression databases

CleanExiHS_OR52E6.
ExpressionAtlasiQ96RD3. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52E6_HUMAN
AccessioniPrimary (citable) accession number: Q96RD3
Secondary accession number(s): Q6IFF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 10, 2002
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.