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Protein

Olfactory receptor 52E6

Gene

OR52E6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52E6
Alternative name(s):
Olfactory receptor OR11-58
Gene namesi
Name:OR52E6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000205409.3
HGNCiHGNC:15215 OR52E6
neXtProtiNX_Q96RD3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 274ExtracellularSequence analysisAdd BLAST15
Transmembranei275 – 295Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini296 – 313CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi390078
PharmGKBiPA32407

Polymorphism and mutation databases

BioMutaiOR52E6
DMDMi20532197

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507751 – 313Olfactory receptor 52E6Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96RD3
PeptideAtlasiQ96RD3
PRIDEiQ96RD3

PTM databases

iPTMnetiQ96RD3
PhosphoSitePlusiQ96RD3

Expressioni

Gene expression databases

CleanExiHS_OR52E6
ExpressionAtlasiQ96RD3 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328878

Structurei

3D structure databases

ProteinModelPortaliQ96RD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCA4 Eukaryota
ENOG4110P6C LUCA
GeneTreeiENSGT00910000144038
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ96RD3
KOiK04257
PhylomeDBiQ96RD3
TreeFamiTF343679

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96RD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIANDTQFH TSSFLLLGIP GLEDVHIWIG FPFFSVYLIA LLGNAAIFFV
60 70 80 90 100
IQTEQSLHEP MYYCLAMLDS IDLSLSTATI PKMLGIFWFN IKEISFGGYL
110 120 130 140 150
SQMFFIHFFT VMESIVLVAM AFDRYIAICK PLWYTMILTS KIISLIAGIA
160 170 180 190 200
VLRSLYMVIP LVFLLLRLPF CGHRIIPHTY CEHMGIARLA CASIKVNIMF
210 220 230 240 250
GLGSISLLLL DVLLIILSHI RILYAVFCLP SWEARLKALN TCGSHIGVIL
260 270 280 290 300
AFSTPAFFSF FTHCFGHDIP QYIHIFLANL YVVVPPTLNP VIYGVRTKHI
310
RETVLRIFFK TDH
Length:313
Mass (Da):35,524
Last modified:May 10, 2002 - v2
Checksum:i6FC174DBDCB20BB3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04806639I → V. Corresponds to variant dbSNP:rs4362173Ensembl.1
Natural variantiVAR_04806748F → L. Corresponds to variant dbSNP:rs10769272Ensembl.1
Natural variantiVAR_04806864C → F. Corresponds to variant dbSNP:rs4495918Ensembl.1
Natural variantiVAR_04806995S → P. Corresponds to variant dbSNP:rs4592451Ensembl.1
Natural variantiVAR_048070133W → R. Corresponds to variant dbSNP:rs10838719Ensembl.1
Natural variantiVAR_048071159I → V. Corresponds to variant dbSNP:rs4357719Ensembl.1
Natural variantiVAR_048072170F → Y. Corresponds to variant dbSNP:rs7943698Ensembl.1
Natural variantiVAR_048073199M → R. Corresponds to variant dbSNP:rs10742809Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065815 Genomic DNA Translation: BAC06034.1
CH471064 Genomic DNA Translation: EAW68758.1
AF399504 Genomic DNA Translation: AAK94989.1
BK004304 Genomic DNA Translation: DAA04702.1
CCDSiCCDS53597.1
RefSeqiNP_001005167.1, NM_001005167.1
UniGeneiHs.534693

Genome annotation databases

EnsembliENST00000329322; ENSP00000328878; ENSG00000205409
GeneIDi390078
KEGGihsa:390078
UCSCiuc010qzq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO52E6_HUMAN
AccessioniPrimary (citable) accession number: Q96RD3
Secondary accession number(s): Q6IFF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 10, 2002
Last modified: February 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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