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Protein

Olfactory receptor 52B2

Gene

OR52B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52B2
Alternative name(s):
Olfactory receptor OR11-70
Gene namesi
Name:OR52B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000255307.1
HGNCiHGNC:15207 OR52B2
neXtProtiNX_Q96RD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 275ExtracellularSequence analysisAdd BLAST15
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 323CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32396

Polymorphism and mutation databases

BioMutaiOR52B2
DMDMi221222519

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507671 – 323Olfactory receptor 52B2Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96RD2
PeptideAtlasiQ96RD2
PRIDEiQ96RD2

PTM databases

iPTMnetiQ96RD2
PhosphoSitePlusiQ96RD2

Expressioni

Gene expression databases

BgeeiENSG00000255307
CleanExiHS_OR52B2

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000432011

Structurei

3D structure databases

ProteinModelPortaliQ96RD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II1I Eukaryota
ENOG410YB92 LUCA
GeneTreeiENSGT00910000144052
HOVERGENiHBG017625
InParanoidiQ96RD2
KOiK04257
OMAiFFTLLTH
OrthoDBiEOG091G0AZH
PhylomeDBiQ96RD2
TreeFamiTF343679

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96RD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHTNVTIFH PAVFVLPGIP GLEAYHIWLS IPLCLIYITA VLGNSILIVV
60 70 80 90 100
IVMERNLHVP MYFFLSMLAV MDILLSTTTV PKALAIFWLQ AHNIAFDACV
110 120 130 140 150
TQGFFVHMMF VGESAILLAM AFDRFVAICA PLRYTTVLTW PVVGRIALAV
160 170 180 190 200
ITRSFCIIFP VIFLLKRLPF CLTNIVPHSY CEHIGVARLA CADITVNIWY
210 220 230 240 250
GFSVPIVMVI LDVILIAVSY SLILRAVFRL PSQDARHKAL STCGSHLCVI
260 270 280 290 300
LMFYVPSFFT LLTHHFGRNI PQHVHILLAN LYVAVPPMLN PIVYGVKTKQ
310 320
IREGVAHRFF DIKTWCCTSP LGS
Length:323
Mass (Da):36,185
Last modified:January 20, 2009 - v3
Checksum:iD7C9A5138AB6AB17
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054126105F → Y. Corresponds to variant dbSNP:rs16909422Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065763 Genomic DNA Translation: BAC05983.1
CH471064 Genomic DNA Translation: EAW68744.1
BC136732 mRNA Translation: AAI36733.1
BC136733 mRNA Translation: AAI36734.1
AF399505 Genomic DNA Translation: AAK94990.1
BK004324 Genomic DNA Translation: DAA04722.1
CCDSiCCDS53598.1
RefSeqiNP_001004052.1, NM_001004052.1
UniGeneiHs.690457

Genome annotation databases

EnsembliENST00000530810; ENSP00000432011; ENSG00000255307
GeneIDi255725
KEGGihsa:255725
UCSCiuc010qzy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO52B2_HUMAN
AccessioniPrimary (citable) accession number: Q96RD2
Secondary accession number(s): Q8NGM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: January 20, 2009
Last modified: February 28, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome